ngr-peptide and Sarcoma-180

ngr-peptide has been researched along with Sarcoma-180* in 1 studies

Other Studies

1 other study(ies) available for ngr-peptide and Sarcoma-180

Article	Year
Design, synthesis, and activity evaluation of a new 5-fluorouracil prodrug containing an Asn-Gly-Arg(NO2)COOCH3 tripeptide. Protein and peptide letters, 2012, Volume: 19, Issue:10 Aminopeptidase N (APN/CD13) of the M1 family is a broad specificity enzyme that is intimately involved in tumor angiogenesis and metastasis. Asparagine-glycine-arginine (NGR) is a tumor-homing tripeptide, which can selectively combine with APN/CD13 that is overexpressed on the surface of some tumor cells. Various anti-tumor drugs can be conjugated to NGR to improve selectivity, efficacy, and to decrease drug toxicity. In this study, a tripeptide NGR(NO2) was synthesized and conjugated with 5-fluorouracil. The anti-tumor activities of this new prodrug were evaluated in vivo. More significant anti-tumor effects were observed over the parent 5-fluorouracil. Topics: Animals; Antimetabolites, Antineoplastic; CD13 Antigens; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Drug Design; Female; Fluorouracil; Human Umbilical Vein Endothelial Cells; Humans; Laminin; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Oligopeptides; Prodrugs; Proteoglycans; Sarcoma 180; Xenograft Model Antitumor Assays	2012

Article

Year

Design, synthesis, and activity evaluation of a new 5-fluorouracil prodrug containing an Asn-Gly-Arg(NO2)COOCH3 tripeptide.

Protein and peptide letters, 2012, Volume: 19, Issue:10

Aminopeptidase N (APN/CD13) of the M1 family is a broad specificity enzyme that is intimately involved in tumor angiogenesis and metastasis. Asparagine-glycine-arginine (NGR) is a tumor-homing tripeptide, which can selectively combine with APN/CD13 that is overexpressed on the surface of some tumor cells. Various anti-tumor drugs can be conjugated to NGR to improve selectivity, efficacy, and to decrease drug toxicity. In this study, a tripeptide NGR(NO2) was synthesized and conjugated with 5-fluorouracil. The anti-tumor activities of this new prodrug were evaluated in vivo. More significant anti-tumor effects were observed over the parent 5-fluorouracil.

Topics: Animals; Antimetabolites, Antineoplastic; CD13 Antigens; Cell Movement; Cells, Cultured; Collagen; Drug Combinations; Drug Design; Female; Fluorouracil; Human Umbilical Vein Endothelial Cells; Humans; Laminin; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Metastasis; Neovascularization, Pathologic; Oligopeptides; Prodrugs; Proteoglycans; Sarcoma 180; Xenograft Model Antitumor Assays

2012