ng-nitroarginine methyl ester has been researched along with Diabetes Mellitus, Type 2 in 51 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (7.84) | 18.2507 |
| 2000's | 34 (66.67) | 29.6817 |
| 2010's | 12 (23.53) | 24.3611 |
| 2020's | 1 (1.96) | 2.80 |
| Authors | Studies |
|---|---|
| Dubey, A; Dubey, H; Gulati, K; Ray, A | 1 |
| Ahmed, MM; Kamar, SS; Mahmoud, MM; Rashed, L; Sabry, MM; Shoukry, HS | 1 |
| Fang, ZH; Gao, JR; Guo, MF; Han, LP; Jiang, NN; Qin, XJ | 1 |
| Dehpour, A; Imran khan, M; Ostadhadi, S; Rajaba, A; Rastegar, H; Shafizadeh, M | 1 |
| Betik, AC; Dwyer, RM; Hong, YH; Keske, MA; McConell, GK; Premilovac, D; Rattigan, S | 1 |
| Duranti, E; Natali, A; Rossi, C; Solini, A; Taddei, S; Virdis, A | 1 |
| Alm, P; Efendic, S; Guenifi, A; Henningsson, R; Jimenez-Feltström, J; Lundquist, I; Mosén, H; Ostenson, CG; Salehi, A | 1 |
| Belin de Chantemèle, EJ; Guihot, AL; Henrion, D; Loufrani, L; Maquignau, M; Toutain, B; Vessières, E | 1 |
| Basu, A; Charkoudian, N; Kingsley-Berg, SA; Roberts, SK; Sokolnicki, LA; Strom, NA | 1 |
| Azoury, KR; Colberg, SR; Parson, HK; Vinik, AI | 1 |
| Aillaud, M; Asagami, T; Azuma, J; Deng, AC; Jin, H; Kundu, RK; Quertermous, T; Reaven, GM; Tsao, PS; Yue, P | 1 |
| Aburada, M; Hemmi, C; Iizuka, S; Ito, M; Kawada, T; Mihara, K; Miyata, S; Nakazawa, M; Sanzen, Y; Shimada, T; Suzuki, W | 1 |
| Barua, A; Galiñanes, M; Standen, NB | 1 |
| Bagi, Z; Beleznai, T; Feher, A; Lansman, SL; Spielvogel, D | 1 |
| Fakher, S; Khalili, A; Khosravi, MB; Nekooeian, AA | 1 |
| Cheng, HT; Dauch, JR; Hsieh, W; Oh, SS; Yanik, BM | 1 |
| Bratz, IN; Damron, DS; DelloStritto, DJ; Guarini, G; Kmetz, JG; Meszaros, JG; Ohanyan, VA; Thodeti, CK; Thoppil, RJ | 1 |
| Afonso, RA; Guarino, MP; Macedo, MP; Raimundo, N; Raposo, JF | 1 |
| Ajayi, AA; Cory, J; Hayes, BE; Hercule, H; Oyekan, AO | 1 |
| Ito, S; Kawano, T; Nakaya, Y; Nisikado, A; Nomura, M | 1 |
| Bagi, Z; Kaley, G; Koller, A | 1 |
| Anderson, TJ; Ellis, A; Pannirselvam, M; Triggle, CR | 1 |
| Ajayi, AA; Hercule, HC; Mutembei, L; Ogungbade, GO; Oyekan, AO | 1 |
| Al-Mulla, F; Al-Saleh, E; Bitar, MS; Dhaunsi, GS; Mustafa, S; Wahid, S | 1 |
| Atkinson, AB; Bell, PM; Fee, JP; McCance, DR; McSorley, PT; Sheridan, B; Young, IS | 1 |
| Devine, A; Dixon, LJ; Henry, W; Hughes, SM; Johnston, GD; Leahey, W; Madden, A; McVeigh, GE; Rooney, K | 1 |
| Dingqunfang, D; Fukatsu, A; Hayashi, T; Iguchi, A; Juliet, PA; Kano-Hayashi, H; Matsui-Hirai, H; Sumi, D; Tsunekawa, T | 1 |
| Chung, AW; Luo, H; McManus, BM; Okon, EB; Padilla, E; Rauniyar, P; Tejerina, T; van Breemen, C | 1 |
| Cheng, ZJ; Finckenberg, P; Grönholm, T; Louhelainen, M; Merasto, S; Mervaala, E; Tikkanen, I | 1 |
| Fujita, K; Funahashi, T; Hibuse, T; Hiuge, A; Kihara, S; Kumada, M; Maeda, K; Maeda, N; Nishizawa, H; Ohashi, K; Ouchi, N; Ryo, M; Shibata, R; Shimomura, I; Walsh, K | 1 |
| Higuchi, M; Hora, K; Kamijo, H | 1 |
| Ergul, A; Harris, A; Hutchinson, J; Sachidanandam, K | 1 |
| Au, LS; Kwan, YW; Lam, TY; Lau, YM; Ngai, SM; Seto, SW; Tsui, KW | 1 |
| Basu, A; Charkoudian, N; Roberts, SK; Sokolnicki, LA; Wilkins, BW | 1 |
| Buus, NH; Bøtker, HE; Bøttcher, M; Madsen, MM; Nielsen, TT; Schmitz, O; Søndergaard, HM | 1 |
| Huang, Y; Lau, CW; Lin, SG; Yu, XY; Yung, LM; Zhong, JC | 1 |
| de Carvalho, MH; de Cássia Tostes Passaglia, R; dos Santos, R; Fortes, ZB; Nigro, D; Oliveira, MA; Rastelli, VM | 1 |
| Bender, SB; Klabunde, RE | 1 |
| Crabtree, MJ; Goligorsky, MS; Gross, SS; Lam, G; Smith, CL | 1 |
| Behnke, BJ; Delp, MD; Donato, AJ; Laughlin, MH; Lesniewski, LA; Ray, CA; Woodman, CR | 1 |
| Gunawardana, SC; Head, WS; Piston, DW | 1 |
| Efendic, S; Jimenez-Feltstrom, J; Lundquist, I; Meidute Abaraviciene, S; Ostenson, CG; Salehi, A | 1 |
| Mancusi, G; Raberger, G; Schütz, W; Sexl, V | 1 |
| Greenhalgh, RM; Hicks, RC; Higman, DJ; Moss, J; Powell, JT | 1 |
| Faletti, A; Gimeno, MA; Gonzalez, ET; Jawerbaum, A; Novaro, V; Sinner, D | 1 |
| Gonda, T; Kato, Y; Kawaguchi, M; Koshimura, K; Murakami, Y; Tsumori, M | 1 |
| Anggård, EE; Carrier, MJ; Desai, KM; Laight, DW | 1 |
| Kagota, S; Kunitomo, M; Nakamura, K; Yamaguchi, Y | 1 |
| Fukui, H; Kadowaki, M; Kuramoto, H; Takaki, M; Yoneda, S | 1 |
| Chaves, MM; Costa, DC; Lima E Silva, FC; Lima E Silva, R; Medina, LO; Nogueira-Machado, JA | 1 |
| Ishimura, N; Nakaya, Y; Takahashi, A; Takishita, E | 1 |
2 trial(s) available for ng-nitroarginine methyl ester and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Endothelial function, insulin action and cardiovascular risk factors in young healthy adult offspring of parents with Type 2 diabetes: effect of vitamin E in a randomized double-blind, controlled clinical trial.
Topics: Adolescent; Adult; Antioxidants; Cross-Over Studies; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Double-Blind Method; Endothelium, Vascular; Female; Forearm; Humans; Insulin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pedigree; Risk Factors; Vitamin E | 2005 |
Contribution of nitric oxide to cutaneous microvascular dilation in individuals with type 2 diabetes mellitus.
Topics: Adult; Aged; Diabetes Mellitus, Type 2; Dilatation, Pathologic; Enzyme Inhibitors; Female; Humans; Male; Microdialysis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Skin; Thermal Conductivity; Vasodilation | 2007 |
49 other study(ies) available for ng-nitroarginine methyl ester and Diabetes Mellitus, Type 2
| Article | Year |
|---|---|
Protective effects of L-arginine on cognitive deficits and biochemical parameters in an experimental model of type-2 diabetes mellitus induced Alzheimer's disease in rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Arginine; Cognition; Diabetes Mellitus, Type 2; Models, Theoretical; NG-Nitroarginine Methyl Ester; Rats; Streptozocin | 2022 |
Interactive effects of apelin, renin-angiotensin system and nitric oxide in treatment of obesity-induced type 2 diabetes mellitus in male albino rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apelin; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Drug Therapy, Combination; Enzyme Inhibitors; Insulin; Insulin Resistance; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Obesity; Rats; Renin-Angiotensin System | 2019 |
To Explore the Pathogenesis of Vascular Lesion of Type 2 Diabetes Mellitus Based on the PI3K/Akt Signaling Pathway.
Topics: Animals; Aorta, Abdominal; Blood Glucose; Blood Pressure; Chronic Disease; Diabetes Mellitus, Type 2; Glycosylation; Heart Rate; Human Umbilical Vein Endothelial Cells; Humans; Male; Neovascularization, Pathologic; NG-Nitroarginine Methyl Ester; Phosphatidylinositol 3-Kinases; Phosphorylation; Prognosis; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction; Treatment Outcome | 2019 |
Anti-pruritic activity of pioglitazone on serotonin-induced scratching in mice: possible involvement of PPAR-gamma receptor and nitric oxide.
Topics: Animals; Arginine; Diabetes Mellitus, Type 2; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pioglitazone; PPAR gamma; Serotonin; Thiazolidinediones | 2014 |
No effect of NOS inhibition on skeletal muscle glucose uptake during in situ hindlimb contraction in healthy and diabetic Sprague-Dawley rats.
Topics: Animals; Biological Transport; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Enzyme Inhibitors; Glucose; Hindlimb; Muscle Contraction; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 2015 |
Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenase.
Topics: Adamantane; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dipeptides; Endothelium, Vascular; Fatty Acids, Unsaturated; Hydrazines; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pyrazoles; Vascular Remodeling; Vasodilation | 2016 |
Impaired glucose-stimulated insulin secretion in the GK rat is associated with abnormalities in islet nitric oxide production.
Topics: Animals; Arginine; Colforsin; Diabetes Mellitus, Type 2; Disease Models, Animal; Enzyme Inhibitors; Female; Glucose; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Wistar | 2008 |
Type 2 diabetes severely impairs structural and functional adaptation of rat resistance arteries to chronic changes in blood flow.
Topics: Acetylcholine; Adaptation, Physiological; Animals; Antioxidants; Caveolin 1; Cyclic N-Oxides; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Indomethacin; Ligation; Male; Membrane Glycoproteins; Mesenteric Arteries; NADPH Oxidase 2; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphoproteins; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Zucker; Regional Blood Flow; Spin Labels; Splanchnic Circulation; Superoxides; Vascular Resistance; Vasodilation; Vasodilator Agents | 2009 |
Skin blood flow and nitric oxide during body heating in type 2 diabetes mellitus.
Topics: Blood Flow Velocity; Body Temperature; Body Temperature Regulation; Case-Control Studies; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Forearm; Heat Stress Disorders; Hot Temperature; Humans; Laser-Doppler Flowmetry; Male; Microcirculation; Microdialysis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Plethysmography; Regional Blood Flow; Skin; Vasodilation | 2009 |
Exercise status affects skin perfusion via prostaglandin, nitric oxide, and EDHF pathways in diabetes.
Topics: Aspirin; Biological Factors; Case-Control Studies; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Exercise; Exercise Therapy; Female; Hot Temperature; Humans; Laser-Doppler Flowmetry; Male; Microdialysis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Skin; Vasodilation | 2009 |
Apelin is necessary for the maintenance of insulin sensitivity.
Topics: Adipokines; AMP-Activated Protein Kinases; Animals; Apelin; Carrier Proteins; Cells, Cultured; Chromones; Deoxyglucose; Diabetes Mellitus, Type 2; Dietary Sucrose; Enzyme Inhibitors; Hyperinsulinism; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Muscle, Skeletal; Myoblasts; NG-Nitroarginine Methyl Ester; Obesity; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Leptin; Signal Transduction; Tritium | 2010 |
A study of cardiovascular function in Tsumura Suzuki obese diabetes, a new model mouse of type 2 diabetes.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Cholesterol, HDL; Diabetes Mellitus, Type 2; Disease Models, Animal; Echocardiography; Endothelium, Vascular; Heart; Hyperglycemia; Hyperinsulinism; Hyperlipidemias; Kidney; Male; Mice; Mice, Inbred Strains; Mice, Obese; NG-Nitroarginine Methyl Ester; Obesity; Pancreas; Reference Values; Vasodilation | 2010 |
Modulation of the nitric oxide metabolism overcomes the unresponsiveness of the diabetic human myocardium to protection against ischemic injury.
Topics: Apoptosis; Atrial Appendage; Cardiotonic Agents; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Humans; Ischemic Preconditioning, Myocardial; Mitochondria; Myocardial Ischemia; Myocardium; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Organ Culture Techniques; Random Allocation; S-Nitroso-N-Acetylpenicillamine | 2011 |
Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes.
Topics: Acetylcholine; Aged; Arginase; Arginine; Arterioles; Coronary Vessels; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitroprusside; Up-Regulation; Vasodilation; Vasodilator Agents | 2011 |
Simultaneous renal hypertension and type 2 diabetes exacerbate vascular endothelial dysfunction in rats.
Topics: Acetylcholine; Animals; Aorta; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Glucose Tolerance Test; Hypertension, Renal; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitroprusside; Phenylephrine; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents; Vasodilator Agents | 2012 |
Neuron-astrocyte signaling network in spinal cord dorsal horn mediates painful neuropathy of type 2 diabetes.
Topics: Animals; Astrocytes; Diabetes Mellitus, Type 2; Diabetic Neuropathies; Dizocilpine Maleate; Enzyme Inhibitors; Glial Fibrillary Acidic Protein; Hyperalgesia; Male; MAP Kinase Signaling System; Mice; Nerve Net; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Phosphorylation; Posterior Horn Cells; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Up-Regulation | 2012 |
Disruption of TRPV1-mediated coupling of coronary blood flow to cardiac metabolism in diabetic mice: role of nitric oxide and BK channels.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Anilides; Animals; Capsaicin; Cinnamates; Coronary Vessels; Diabetes Mellitus, Type 2; Diabetic Cardiomyopathies; Enzyme Inhibitors; Large-Conductance Calcium-Activated Potassium Channels; Male; Mice; Mice, Inbred C57BL; Microvessels; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptides; TRPV Cation Channels; Vasoconstrictor Agents; Vasodilation | 2012 |
Hepatic glutathione and nitric oxide are critical for hepatic insulin-sensitizing substance action.
Topics: Animals; Buthionine Sulfoximine; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glutathione; Injections, Intravenous; Insulin; Insulin Resistance; Liver; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Parasympathetic Nervous System; Portal System; Rats; Rats, Wistar | 2003 |
Gender difference in vascular and platelet reactivity to thromboxane A(2)-mimetic U46619 and to endothelial dependent vasodilation in Zucker fatty (hypertensive, hyperinsulinemic) diabetic rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Angiotensin II; Animals; Blood Pressure; Diabetes Mellitus, Type 2; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Female; Kidney Cortex; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Platelet Aggregation; Rats; Rats, Zucker; Renal Circulation; Sex Characteristics; Vasoconstrictor Agents; Vasodilation | 2003 |
Supplementation of L-arginine improves hypertension and lipid metabolism but not insulin resistance in diabetic rats.
Topics: Animals; Arginine; Body Weight; Diabetes Mellitus, Type 2; Dietary Supplements; Glucose Clamp Technique; Glucose Tolerance Test; Hypertension; Insulin; Male; Metabolic Syndrome; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Triglycerides | 2003 |
PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes.
Topics: Acetylcholine; Adenosine; Animals; Arterioles; Biological Availability; Coronary Vessels; Diabetes Mellitus, Type 2; Disease Models, Animal; Hypoglycemic Agents; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Oxidative Stress; Receptors, Cytoplasmic and Nuclear; Rosiglitazone; Thiazolidinediones; Transcription Factors; Vasodilation | 2004 |
Catalase has negligible inhibitory effects on endothelium-dependent relaxations in mouse isolated aorta and small mesenteric artery.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Apamin; Cardiovascular Agents; Catalase; Charybdotoxin; Diabetes Mellitus, Type 2; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Indomethacin; Male; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Potassium Channel Blockers; Potassium Chloride; Quinoxalines; Tetraethylammonium; Vasodilator Agents | 2003 |
Alteration in endothelin receptor sub-type responsiveness and in the endothelin-TXA(2) mimetic U46619 interaction, in type-2 hypertensive diabetic Zucker rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Diabetes Mellitus, Type 2; Drug Interactions; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Hypertension; Kidney Cortex; Kidney Medulla; Male; NG-Nitroarginine Methyl Ester; Oligopeptides; Piperidines; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptor Cross-Talk; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Thromboxane A2 | 2004 |
Nitric oxide dynamics and endothelial dysfunction in type II model of genetic diabetes.
Topics: Animals; Aorta, Thoracic; Biopterins; Body Weight; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; In Vitro Techniques; Isoprostanes; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Oxidation-Reduction; Protein Subunits; Proteins; Rats; Rats, Inbred Strains; Rats, Wistar; Superoxide Dismutase; Superoxides; Tyrosine; Vasodilation; Vasodilator Agents | 2005 |
Increased superoxide production in hypertensive patients with diabetes mellitus: role of nitric oxide synthase.
Topics: Adult; Aged; Biomarkers; Biphenyl Compounds; Blood Platelets; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Hypertension; In Vitro Techniques; Luminescent Measurements; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Onium Compounds; Oxidative Stress; Quinacrine; Superoxides | 2005 |
NADPH oxidase inhibitor, apocynin, restores the impaired endothelial-dependent and -independent responses and scavenges superoxide anion in rats with type 2 diabetes complicated by NO dysfunction.
Topics: Acetophenones; Animals; Antioxidants; Aorta; Arteriosclerosis; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endothelium; Enzyme Inhibitors; Free Radical Scavengers; Immunohistochemistry; Macrophages; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidation-Reduction; Rats; Rats, Inbred OLETF; Superoxides | 2005 |
Compromised arterial function in human type 2 diabetic patients.
Topics: Adult; Aged; Arteries; Diabetes Mellitus, Type 2; Endothelium, Vascular; Female; Humans; Male; Mammary Arteries; Middle Aged; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Phenylephrine; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Vasoconstriction | 2005 |
Vascular and renal effects of vasopeptidase inhibition and angiotensin-converting enzyme blockade in spontaneously diabetic Goto-Kakizaki rats.
Topics: Acetylcholine; Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Blood Vessels; Diabetes Mellitus, Type 2; Diclofenac; Enalapril; Endothelium, Vascular; Kidney; Male; Metalloproteases; Neprilysin; NG-Nitroarginine Methyl Ester; Nitroprusside; Pyridines; Rats; Rats, Inbred Strains; Rats, Wistar; Sodium, Dietary; Thiazepines; Vasodilator Agents | 2005 |
Adiponectin replenishment ameliorates obesity-related hypertension.
Topics: Adenoviridae; Adiponectin; Animals; Aorta; Blood Pressure; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Transfer Techniques; Genetic Vectors; Hypertension; Insulin Resistance; Intramolecular Oxidoreductases; Male; Mice; Mice, Inbred Strains; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Obesity; RNA, Messenger; Sodium Chloride, Dietary | 2006 |
Chronic inhibition of nitric oxide production aggravates diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats.
Topics: Animals; Arginine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Enzyme Inhibitors; Kidney Glomerulus; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Proteinuria; Rats; Rats, Inbred OLETF; Time Factors | 2006 |
Microvascular versus macrovascular dysfunction in type 2 diabetes: differences in contractile responses to endothelin-1.
Topics: Acetylcholine; Animals; Basilar Artery; Diabetes Mellitus, Type 2; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Isometric Contraction; Male; Mesenteric Arteries; Muscle Contraction; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred Strains; Rats, Wistar; Serotonin; Vasoconstrictor Agents; Vasodilator Agents | 2006 |
Impairment of the vascular relaxation and differential expression of caveolin-1 of the aorta of diabetic +db/+db mice.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Glucose; Blotting, Western; Caveolin 1; Cromakalim; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Insulin; Isoproterenol; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitroprusside; Receptor, Muscarinic M3; RNA, Messenger; Vasodilation; Vasodilator Agents | 2006 |
Impact of type 2 diabetes on nitric oxide and adrenergic modulation of myocardial perfusion.
Topics: Adenosine; Adrenergic alpha-Antagonists; Blood Pressure; Coronary Circulation; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Heart Rate; Humans; Hyperemia; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phentolamine; Sympathetic Nervous System; Vascular Resistance; Vasodilator Agents | 2007 |
Apelin modulates aortic vascular tone via endothelial nitric oxide synthase phosphorylation pathway in diabetic mice.
Topics: Acetylcholine; Adipokines; Angiotensin II; Animals; Aorta; Apelin; Apelin Receptors; Blotting, Western; Carrier Proteins; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Humans; In Vitro Techniques; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred Strains; Models, Animal; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, G-Protein-Coupled; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasodilation; Vasodilator Agents | 2007 |
Lack of potentiation of bradykinin by angiotensin-(1-7) in a type 2 diabetes model: role of insulin.
Topics: Angiotensin I; Animals; Animals, Newborn; Blood Glucose; Bradykinin; Diabetes Mellitus, Type 2; Drug Interactions; Gene Expression; Hypoglycemic Agents; Immunohistochemistry; Indomethacin; Insulin; Male; NG-Nitroarginine Methyl Ester; Ouabain; Peptide Fragments; Rats; Rats, Wistar; Receptors, Bradykinin; Reverse Transcriptase Polymerase Chain Reaction; Streptozocin; Tetraethylammonium; Vasodilation | 2007 |
Altered role of smooth muscle endothelin receptors in coronary endothelin-1 and alpha1-adrenoceptor-mediated vasoconstriction in Type 2 diabetes.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Coronary Vessels; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Carbohydrates; Dietary Fats; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Obesity; Oligopeptides; Peptides, Cyclic; Phenylephrine; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Adrenergic, alpha-1; Vasoconstriction | 2007 |
Ratio of 5,6,7,8-tetrahydrobiopterin to 7,8-dihydrobiopterin in endothelial cells determines glucose-elicited changes in NO vs. superoxide production by eNOS.
Topics: Animals; Biopterins; Blood Glucose; Cell Line; Diabetes Mellitus, Type 2; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Glucose; Glutathione; Mice; Mitochondria; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Protein Binding; Rats; Rats, Zucker; Superoxides; Time Factors; Tritium | 2008 |
Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension.
Topics: Animals; Arterioles; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Down-Regulation; Endothelin-1; Enzyme Inhibitors; Hypertension; Insulin; Isoproterenol; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; Potassium Chloride; Prediabetic State; Rats; Rats, Zucker; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Dimethyl amiloride improves glucose homeostasis in mouse models of type 2 diabetes.
Topics: Amiloride; Amino Acids, Cyclic; Animals; Arginine; Blood Glucose; Diabetes Mellitus, Type 2; Disease Models, Animal; Drug Synergism; Homeostasis; Hydrogen-Ion Concentration; Insulin; Insulin Secretion; Insulin-Secreting Cells; Keto Acids; Ketoglutarate Dehydrogenase Complex; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mitochondria; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Sodium-Calcium Exchanger | 2008 |
Excessive islet NO generation in type 2 diabetic GK rats coincides with abnormal hormone secretion and is counteracted by GLP-1.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Glucagon; Glucagon-Like Peptide 1; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Rats, Wistar | 2008 |
Age-related changes in vascular reactivity in genetically diabetic rats.
Topics: Acetylcholine; Aging; Animals; Arginine; Calcimycin; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Endothelium, Vascular; In Vitro Techniques; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Zucker | 1995 |
The influence of diabetes on the vasomotor responses of saphenous vein and the development of infra-inguinal vein graft stenosis.
Topics: Aged; Aged, 80 and over; Amputation, Surgical; Blood Vessel Prosthesis; Bradykinin; Calcimycin; Collagen; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Endothelium, Vascular; Female; Fibrinogen; Humans; In Vitro Techniques; Indomethacin; Ischemia; Leg; Male; Microscopy, Electron; Middle Aged; NG-Nitroarginine Methyl Ester; Postoperative Complications; Saphenous Vein; Time Factors; Vascular Diseases; Vascular Surgical Procedures; Vasodilation | 1997 |
Increased prostaglandin E generation and enhanced nitric oxide synthase activity in the non-insulin-dependent diabetic embryo during organogenesis.
Topics: Animals; Diabetes Mellitus, Type 2; Embryonic and Fetal Development; Enzyme Inhibitors; Female; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Pregnancy; Pregnancy in Diabetics; Prostaglandins E; Rats; Rats, Wistar | 1998 |
Antihypertensive effect of insulin via nitric oxide production in the Zucker diabetic fatty rat, an animal model for non-insulin-dependent diabetes mellitus.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Enzyme Activation; Enzyme Inhibitors; Histocytochemistry; Humans; Hypertension; In Vitro Techniques; Insulin; Male; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Zucker; Recombinant Proteins | 1999 |
Endothelial dysfunction accompanies a pro-oxidant, pro-diabetic challenge in the insulin resistant, obese Zucker rat in vivo.
Topics: Acetylcholine; Animals; Antioxidants; Area Under Curve; Body Weight; Buthionine Sulfoximine; Cyclic GMP; Diabetes Mellitus, Type 2; Endothelium, Vascular; Enzyme Inhibitors; Hemodynamics; Hydroquinones; Insulin Resistance; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Obesity; Oxidants; Rats; Rats, Zucker | 2000 |
Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus.
Topics: Acetylcholine; Animals; Aorta; Biological Factors; Blood Glucose; Body Weight; Cardiovascular Agents; Charybdotoxin; Diabetes Mellitus, Type 2; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Guanidines; In Vitro Techniques; Indomethacin; Lipids; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Inbred OLETF; Renal Artery; Vasodilation | 2000 |
Enhanced colonic peristalsis by impairment of nitrergic enteric neurons in spontaneously diabetic rats.
Topics: Animals; Arginine; Blood Glucose; Body Weight; Colon; Diabetes Mellitus, Type 2; Enteric Nervous System; Enzyme Inhibitors; In Vitro Techniques; Male; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Peristalsis; Rats; Rats, Inbred OLETF; Reflex | 2001 |
Effect in vitro of cyclic nucleotides-elevating agents on nitric oxide production by human granulocytes from type 2-diabetic patients.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Aged; Cyclic AMP; Cyclic GMP; Diabetes Mellitus, Type 2; Female; Granulocytes; Humans; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrites; Reference Values | 2002 |
Chronic feeding of a nitric oxide synthase inhibitor induces postprandial hypertriglyceridemia in type 2 diabetic model rats, Otsuka Long-Evans Tokushima Fatty rats, but not in nondiabetic rats.
Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Body Weight; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dietary Fats; Disease Models, Animal; Eating; Enzyme Inhibitors; Hypertriglyceridemia; Insulin; Lipid Metabolism; Lipids; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Obesity; Postprandial Period; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Species Specificity; Time | 2002 |