ng-nitroarginine methyl ester has been researched along with Blood Pressure, High in 1118 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 275 (24.60) | 18.2507 |
| 2000's | 444 (39.71) | 29.6817 |
| 2010's | 307 (27.46) | 24.3611 |
| 2020's | 92 (8.23) | 2.80 |
| Authors | Studies |
|---|---|
| Bunbupha, S; Chaihongsa, N; Maneesai, P; Pakdeechote, P; Potue, P; Sangartit, W | 1 |
| Ademosun, AO; Ajeigbe, OF; Oboh, G; Umar, HI | 1 |
| Chaichompoo, W; Onsa-Ard, A; Panthiya, L; Suksamrarn, A; Tocharus, C; Tocharus, J | 1 |
| Boarescu, I; Boarescu, PM; Bocșan, IC; Bolboacă, SD; Bulboacă, AE; Buzoianu, AD; Mada, RO; Neagu, N; Pop, RM; Popa, ID; Roşian, ŞH; Rus, V | 1 |
| Akerman, AP; Fujii, N; Kenny, GP; King, KE; McGarr, GW; Ruzicka, M | 1 |
| Akdad, M; Azzane, A; Azzaoui, B; Bouadid, I; Eddouks, M | 1 |
| Aekthammarat, D; Pannangpetch, P; Proongkhong, T; Srisuwan, S; Tangsucharit, P; Thanaruksa, R | 1 |
| Alberstein, RA; Joo Turoni, CM; Marañón, RO; Peral de Bruno, M; Sanchez, RS | 1 |
| Amano, T; Boulay, P; Fujii, N; Kenny, GP; King, KE; Meade, RD; Ruzicka, M; Schmidt, MD | 1 |
| Ahmad, T; Khan, T; Shah, AJ; Ul Haq, I | 1 |
| Booz, C; Buchner, K; Eichler, K; Frey, N; Gruber-Rouh, T; Gruenewald, LD; Hagenmueller, M; Hardt, SE; Koch, V; Martin, S; März, W; Riffel, JH; Vogl, TJ; Yel, I | 1 |
| Akdad, M; Bouadid, I; Eddouks, M | 1 |
| Chanda, D; Iqbal, H; Luqman, S; Mishra, D; Negi, AS; Singh, D; Vamadevan, B; Verma, AK; Yadav, P | 1 |
| Elliott, J; Finding, EJT; Harris, PA; Menzies-Gow, NJ | 1 |
| Allbee, ML; Arenaz, CM; Chiasson, VL; Goodlett, BL; Henley, MR; Mitchell, BM; Navaneethabalakrishnan, S; Pickup, EJ; Sims, BM | 1 |
| Oboh, G; Ogunsuyi, OB; Oluokun, OO; Oyeleye, SI | 1 |
| Agunloye, OM; Bello, TG; Oboh, G | 1 |
| Ma, S; Wang, DH; Zhong, B | 1 |
| André, H; Arroyo-Barrios, A; Mate, A; Reyes-Goya, C; Santana-Garrido, Á; Vázquez, CM | 1 |
| Acevedo Barrios, MB; Alvarenga, NL; Arrúa, KG; Arrua, W; Campuzano Benitez, AM; Campuzano-Bublitz, MA; Centurión, J; Figueredo Thiel, SJ; Gonzalez, JE; Heinichen, OY; Hellión-Ibarrola, MC; Ibarrola, DA; Kennedy, ML; Montalbetti, Y; Ovando Soria, FM; Rodas González, EI; Soverina Escobar, MS | 1 |
| Bao, C; Chen, A; Han, Y; Liang, S; Pan, Y; Tang, H; Wang, X | 1 |
| Fares, N; Ismail, A; Saliba, Y | 1 |
| Dang, Q; Han, C; Li, M; Li, P; Li, Y; Li, Z; Yang, Y | 1 |
| Byun, N; Cho, GJ; Choi, M; Choi, SJ; Hwang, JR; Kim, JS; Oh, SY; Roh, CR; Seok, YS; Sung, JH | 1 |
| Balasubbramanian, D; Chiasson, VL; Goodlett, BL; Konatham, S; Love, SE; Luera, EM; Mitchell, BM; Navaneethabalakrishnan, S; Rutkowski, JM; Wedgeworth, S | 1 |
| Amtaghri, S; Eddouks, M; Slaoui, M | 1 |
| Araújo Ribeiro, LA; Da Silva Moraes, VG; de Lima, RS; de Marins, MLR; de Oliveira Cardoso, MV; de Queiroz, DB; Nunes, JA; Silva, FS | 1 |
| Amssayef, A; Bouadid, I; Eddouks, M | 1 |
| Amssayef, A; Amthaghri, S; Eddouks, M; Slaoui, M | 1 |
| Ahante, E; Anachuna, KK; Asiwe, JN; Ben-Azu, B; Edje, KE; Eduviere, AT; Moke, EG; Oghoghovwe, IJ; Omogbai, EKI; Omogbiya, AI; Osagie-Eweka, SDE; Uchendu, AP; Umukoro, EK | 1 |
| Adedapo, AA; Ajani, OS; Ajibade, TO; Audu Yakubu, M; Hassan, FO; Jarikre, TA; Joy McGaw, L; Kayoka-Kabongo, PN; Nkadimeng, SM; Obemisola Aro, A; Obukowho Emikpe, B; Oguntibeju, OO; Ola-Davies, OE; Olugbenga Oyeyemi, M; Omobowale, TO; Oyagbemi, AA; Saba, AB; Soetan, KO | 1 |
| Grujić-Milanović, J; Ivanov, M; Jaćević, V; Jovović, D; Karanović, D; Mihailović-Stanojević, N; Milanović, SD; Miloradović, Z; Vajić, UJ | 1 |
| Adebayo, AA; Adedayo, BC; Ademosun, AO; Oboh, G | 1 |
| Bruno, RM; Cappelli, F; Duranti, E; Mengozzi, A; Moriconi, D; Nannipieri, M; Taddei, S; Virdis, A | 1 |
| Na, C; Wang, Y; Yang, X | 1 |
| Alsahli, TG; Bashir, A; Ehsan, R; Gasparotto Junior, A; Jahan, S; Malik, MNH; Razzaq, MA; Younis, W | 1 |
| Iampanichakul, M; Khamseekaew, J; Maneesai, P; Pakdeechote, P; Potue, P; Rattanakanokchai, S; Settheetham-Ishida, W | 1 |
| Chen, M; Hu, Q; Hu, X; Shen, X; Tao, L; Wang, S | 1 |
| Crislip, GR; Elmarakby, AA; Saad, KM; Sullivan, JC | 1 |
| Ademosun, A; Oboh, G; Ojueromi, O; Peace, O | 1 |
| Khamseekaew, J; Maneesai, P; Pakdeechote, P; Poasakate, A; Potue, P; Rattanakanokchai, S; Sangartit, W | 1 |
| Banegas, I; Domínguez-Vías, G; Durán, R; Martínez-Cañamero, M; Prieto, I; Ramírez-Sánchez, M; Segarra, AB; Vives, F | 1 |
| Albino, AH; Arias, SCA; Ávila, VF; Faustino, VD; Foresto-Neto, O; Fujihara, CK; Malheiros, DMAC; Oliveira, KC; Saraiva Camara, NO; Volpini, RA; Zambom, FFF; Zatz, R | 1 |
| Adejumobi, OA; Aluko, EO; Fasanmade, AA | 1 |
| Aydoğdu, N; Kandemir, N; Kaya, O; Taştekin, E; Tayfur, P; Yalçınkaya Yavuz, Ö | 1 |
| Castrejón-Téllez, V; Cervantes-Yañez, EZ; Del Valle-Mondragón, L; Flores-Chávez, P; Guarner-Lans, V; Martínez-Memije, R; Oidor-Chan, VH; Pastelín-Hernández, G; Pérez-Torres, I; Soto-Peredo, CA; Torres-Narváez, JC; Varela-López, E; Vargas-González, Á | 1 |
| Jan-On, G; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Sangartit, W; Sattayasai, J; Senaphan, K | 1 |
| Amssayef, A; Eddouks, M | 1 |
| Chen, F; Chen, X; Li, C; Liang, X; Liao, Y; Pan, Y; Qiu, Z; Wei, Y; Wu, D; Yan, X; Yang, S; Zhang, K; Zhou, Y; Zhou, Z | 1 |
| Eddouks, M; El-Ouady, F | 2 |
| Pechanova, O; Torok, J; Vrankova, S; Zemancikova, A | 1 |
| Breyer, RM; Carver, LS; do Carmo, LS; Harrison, DG; Itani, HA; Xiao, L | 1 |
| Banegas, I; de Gasparo, M; Luna, JD; Martínez-Cañamero, M; Prieto-Gomez, I; Ramírez-Sánchez, M; Segarra, AB | 1 |
| Bonacio, GF; Dias-Junior, CA; Nascimento, RA; Possomato-Vieira, JS; Rizzi, E | 1 |
| Chiang, SS; Chu, CY; Hsu, CK; Hsu, FL; Liu, CF | 1 |
| Ajebli, M; Akdad, M; Breuer, A; Eddouks, M; Khallouki, F; Owen, RW | 1 |
| Behairy, SF; El-Maraghy, NN; Elshazly, SM; Soliman, E | 1 |
| Gillette, TG; Hill, JA; Jiang, N; Lavandero, S; May, HI; Schiattarella, GG; Tong, D | 1 |
| Carey, RM; Erdbrügger, U; Good, ME; Howell, NL; Isakson, BE; La Salvia, S; Le, TH; Musante, L | 1 |
| Balis, P; Berenyiova, A; Cacanyiova, S; Grman, M; Kurakova, L; Misak, A; Ondrias, K; Ondriasova, E; Tomasova, L | 1 |
| Akdad, M; Eddouks, M | 1 |
| Boonla, O; Jan-On, G; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Sangartit, W; Senaphan, K; Thongraung, C | 1 |
| Balasubbramanian, D; Baranwal, G; Clark, MC; Goodlett, BL; Mitchell, BM; Rutkowski, JM | 1 |
| Hasmono, D; Hijriani, N; Yusetyani, L | 1 |
| Chies, AB; Oliveira, PB; Oliveira, PR; Rossignoli, PS; Spadella, MA | 1 |
| Bellini, C; Caulk, AW; Ferruzzi, J; Humphrey, JD; Murtada, SI; Spronck, B | 1 |
| Abatuci, Y; Faure, S; Helesbeux, JJ; Legeay, S; Trân, K | 1 |
| Cabral, PHB; Campos, R; Costa, PPC; de Sousa, EHS; do Nascimento, NRF; Fonteles, MC; Gomes, VM; Lopes, LGF; Santos, CF; Waller, SB | 1 |
| Joseph, J; Kanthlal, SK; M, V; P, UD; Paul, B | 1 |
| Aluko, EO; Fasanmade, AA; Omobowale, TO; Oyagbemi, AA | 1 |
| Adedapo, AA; Adedapo, ADA; Ajayi, AM; Ekwunife, NL; Falayi, OO; Omobowale, TO; Oyagbemi, A | 1 |
| Castania, JA; Dias, DPM; Domingos-Souza, G; Fazan, R; Ferreira, NS; Martinez, D; Meschiari, CA; Pereira, CA; Santos-Almeida, FM; Silva, LEV; Tostes, RC | 1 |
| Hayat, MJ; Miller, JT; Otis, JS; Quyyumi, AA; Turner, CG; Wong, BJ | 1 |
| Adedapo, AA; Adejumobi, OA; Asenuga, ER; Falayi, OO; Hassan, FO; McGaw, LJ; Nkadimeng, SM; Ogunmiluyi, IO; Ogunpolu, BS; Oguntibeju, OO; Ola-Davies, OE; Omobowale, TO; Owolabi, AM; Oyagbemi, AA; Saba, AB; Soetan, KO; Yakubu, MA | 1 |
| Arcanjo, DDR; Cavalcante, GL; da Silva, MTB; Ferreira, FN; Filho, ALMM; Sabino, JPJ; Soriano, RN | 1 |
| Mizuno, R; Mukohda, M; Ozaki, H | 1 |
| Joo Turoni, CM; Marañón, RO; Peral de Bruno, M | 1 |
| Aluko, EO; Fasanmade, AA; Nna, VU | 1 |
| Ayuzawa, N; Chen, X; Fujita, T; Kang, L; Kawakami-Mori, F; Koid, SS; Liu, B; Ogura, S; Reheman, L; Shimosawa, T; Wang, C; Yatomi, Y; Yeerbolati, A | 1 |
| Feelisch, M; Joles, JA; Klooster, A; Minnion, M; Nguyen, ITN; van Goor, H; Verhaar, MC | 1 |
| Bao, C; Chen, L; Du, S; Fang, B; Guan, Y; Jia, X; Li, Q; Luan, Z; Qian, L; Sui, X; Wang, N; Wang, S; Xu, H; Yang, G; Ye, L; Zhang, X; Zheng, F | 1 |
| Anderson, N; Aziz, Q; Li, Y; Ojake, L; Tinker, A | 1 |
| Álvares, ADCM; Amaral, NO; Bessa, ASM; Castro, CH; de Freitas, MAG; de Freitas, SM; de Oliveira, SA; Honda, DE; Mehdad, A; Naves, LM; Pedrino, GR; Pontes, CNR; Ramada, MHS | 1 |
| Ajebli, M; Amssayef, A; Eddouks, M | 1 |
| Adedapo, AA; Ademosun, AO; Ajibade, TO; Oboh, G; Ojueromi, OO; Omayone, TP; Oyagbemi, AA | 1 |
| Al-Motrefi, AA; Alorainey, BI; Bukhari, IA; Campbell, WB; Hammock, BD; Mahmoud, A | 1 |
| Phachonpai, W; Tongun, T | 1 |
| Ajebli, M; Eddouks, M | 3 |
| Bhat, A; Dasari, D; Dhar, A; Goyal, SG; Jadhav, KB; Kalra, J; Mangali, S | 1 |
| Kamkar-Del, Y; Mohebbati, R; Shafei, MN | 2 |
| Bunbupha, S; Chiangsaen, P; Maneesai, P; Pakdeechote, P; Poasakate, A; Settheetham-Ishida, W | 1 |
| Ikeda, T; Katsuragi, S; Kawamura, T; Maki, S; Tachibana, R; Takeuchi, H; Tanaka, H; Tanaka, K; Toriyabe, K; Yoshikawa, K | 1 |
| Abdulla, MH; Ahmad, A; Ahmad, FU; Akhtar, S; Chia, TY; Hassan, Z; Johns, EJ; Kaur, G; Khan, NA; Mei, HY; Murugaiyah, V; Sattar, MA | 1 |
| Adler, J; Aïssi, D; Duque Escobar, J; Längst, N; Lukowski, R; Müller, C; Schweigert, O; Tong, T; Trégouët, DA; Zeller, T | 1 |
| Barreto, AS; Batista, MVA; Carvalho, JS; de Souza Araújo, AA; Dos Santos, DM; Oliveira Santos, LAB; Oliveira, AMS; Quintans-Júnior, LJ; Serafini, MR; Silva, EAP; Siqueira Quintans, JS; Viana Santos, MR | 1 |
| Liman, AA; Onyike, E; Salihu, A | 1 |
| Champin, T; Chevrollier, A; Fassot, C; Grenier, C; Grimaud, L; Henni, S; Henrion, D; Lelièvre, E; Lenaers, G; Loufrani, L; Munier, M; Nguyen, PMC; Proux, C; Prunier, D; Reynier, P; Richard, A; Robert, P; Sarzi, E; Vessières, E | 1 |
| Berkban, T; Kanla, P; Mothong, W; Pakdeechote, P; Prachaney, P; Saengnak, B; Samrid, R | 1 |
| Banegas, I; de Gasparo, M; Domínguez-Vías, G; Martínez-Cañamero, M; Prieto, I; Ramírez-Sánchez, M; Segarra, AB; Villarejo, AB | 1 |
| Ahad, A; Al-Jenoobi, FI; Al-Mohizea, AM; Alam, MA; Bin Jardan, YA; Raish, M | 1 |
| Huang, S; Jia, Z; Niu, Y; Shi, W; Wang, S; Yu, J; Zhang, A; Zhang, Y; Zhou, W | 1 |
| Ali, NA; El Gendy, ANG; Farrag, AH; Mohamed, SH; Ragab, TIM; Shalaby, ASG; Shalby, AB | 1 |
| Jang, JH; Jin, CL; Kim, SJ; Oh, GT; Wu, YN; Zhang, YH; Zhao, ZH | 1 |
| Angeli, JK; Faria, TO; Lizardo, JHF; Mello, LGM; Pinto, GC; Stefanon, I; Vassallo, DV | 1 |
| Aghaei, I; Arjmand, S; Shabani, M; Tondar, M; Yousefzadeh Chabok, S | 1 |
| Hein, TW; Kuo, L; Lu, G; Ren, Y; Tsai, SH; Xu, X | 1 |
| Bechara, LRG; de Sousa, LGO; Fernandes, T; Jordão, CP; Oliveira, EM; Ramires, PR; Tanaka, LY | 1 |
| Berg, G; Bertera, FM; Carranza, A; Chiappetta, DA; Del Mauro, JS; Donato, M; Fernandez Machulsky, N; Gelpi, RJ; González, GE; Gorzalczany, SB; Höcht, C; Morales, C; Morettón, MA; Prince, PD; Taira, CA | 1 |
| Aziz, M; Bnouham, M; Bouanani, NE; Fischmeister, R; Hadda, TB; Hakkou, Z; Leblais, V; Legssyer, A; Maciuk, A; Mekhfi, H; Patel, S; Rauf, A; Shaheen, U; Ziyyat, A | 1 |
| Li, Z; Liu, Y; Pang, X; Wang, Y; Wei, Z; Yin, S; Zhang, F | 1 |
| Acevedo-Fernández, JJ; Betancur-Ancona, D; Ciau-Solís, NA | 1 |
| Amaral, TAS; Carvalho, LCRM; Costa, CA; Moura, RS; Ognibene, DT; Resende, AC; Rocha, APM | 1 |
| Benjamin, LE; Bhatt, RS; Chang, S; Dvorak, AM; Dvorak, HF; Jaminet, SC; Kang, PM; Masse, E; Nagy, JA; Sciuto, TE; Shen, M; Sitohy, B | 1 |
| Adamcova, M; Aziriova, S; Balazova, L; Celec, P; Krajcirovicova, K; Pechanova, O; Repova, K; Simko, F; Tothova, L; Vrankova, S; Zorad, S | 1 |
| El-Ashmony, SM; Fatani, SH; Kamel, HF; Shamardl, HA | 1 |
| Jaarin, K; Juliana, AH; Kamisah, Y; Zuhair, JSF | 1 |
| Aboubakar, BFO; Bilanda, DC; Dimo, T; Dzeufiet, PDD; Kamtchouing, P; Kouakep, L; Tedong, L | 1 |
| Aslan, M; Basralı, F; Nasırcılar Ülker, S; Özcan, F; Özen, N; Şentürk, ÜK; Ülker, P | 1 |
| Adedara, IA; Adeyemo, MO; Ajibade, TO; Alake, SE; Farombi, EO; Olajide, LO | 2 |
| Endres, BT; Geurts, AM; Ilatovskaya, DV; Levchenko, V; Palygin, O; Staruschenko, A | 1 |
| Andrade, SF; Boeing, T; da Silva, LM; de Souza, P; Mariott, M | 1 |
| Abdel Kawy, HS | 1 |
| Abd-Eldayem, AM; Abdel-Zaher, AO; El-Refaiy, AEM; Farghaly, HSM | 1 |
| Ferreira, GC; Pinheiro, LC; Tanus-Santos, JE; Toledo, JC; Vilalva, KH | 1 |
| Adamcova, M; Aziriova, S; Baka, T; Krajcirovicova, K; Paulis, L; Poglitsch, M; Reiter, RJ; Repova, K; Simko, F; Zorad, S | 1 |
| Acar, N; Keles-Celik, N; Sekerci, R; Tepekoy, F; Ustunel, I | 1 |
| Abouelkheir, GR; Balasubbramanian, D; Hudson, KR; Johnson, ER; Lopez Gelston, CA; Lopez, AH; Mitchell, BM; Muthuchamy, M; Rutkowski, JM | 1 |
| Hu, X; Jiang, T; Li, L; Luo, J; Pan, X; Pei, Z; Xiao, C; Zhang, L; Zheng, H | 1 |
| Atucha, NM; Castillo, J; García-Estañ, J; O'Valle, F; Ortiz, MC; Paredes, MD; Romecín, P | 1 |
| Akyazi, I; Erkasap, N; Kus, G; Kutlay, O; Ozkurt, M; Ozyurt, R; Uysal, O; Uzuner, K | 1 |
| Cheng, P; Gao, S; Hu, J; Lv, FH; Zhu, FQ | 1 |
| Chen, R; Ruan, G; Sun, Q; Xin, F | 1 |
| de la Visitación, N; Duarte, J; Jiménez, R; Olivares, M; Robles-Vera, I; Romero, M; Sánchez, M; Toral, M | 1 |
| Berenyiova, A; Cacanyiova, S; Dovinova, I; Jansen, E; Kristek, F; Kvandova, M; Majzunova, M | 1 |
| Gulhan, MF | 1 |
| Barančík, M; Berenyiová, A; Dovinová, I; Hrabárová, E; Jansen, E; Kvandová, M; Majzúnová, M | 1 |
| Almenara, CCP; Marcarini, WD; Marques, VB; Nunes, DO; Padilha, AS; Ribeiro Júnior, RF | 1 |
| Chen, JR; Huang, WC; Ko, J; Yang, HY; Yeh, WJ | 1 |
| Alves, PH; Castro, CH; Ianzer, D; Mendes, EP; Nunes, ADC | 1 |
| Bagatini, MD; Belló-Klein, A; Cardoso, AM; Carvalho, F; Gutierres, JM; Manfredi, LH; Morsch, VM; Rubin, MA; Schetinger, MRC; Sévigny, J; Tremblay, A; Zanini, D | 1 |
| Adamcova, M; Aziriova, S; Baka, T; Krajcirovicova, K; Paulis, L; Repova, K; Simko, F | 1 |
| Aekthammarat, D; Pannangpetch, P; Tangsucharit, P | 1 |
| Baka, T; Simko, F | 1 |
| Gwebu, ET; Mahlakata, F; Nkeh-Chungag, BN; Oyedeji, OO; Sewani-Rusike, CR; Tata, CM | 1 |
| Kukongviriyapan, U; Maneesai, P; Pakdeechote, P; Potue, P; Prachaney, P; Wunpathe, C | 1 |
| Haefliger, JA; Kurtz, A; Le Gal, L; Mazzolai, L; Meda, P; Pellegrin, M; Santoro, T; Wagner, C | 1 |
| Ashpole, NM; Carvalho, FS; Castro, CH; Costa, EA; Fajemiroye, JO; Franco, OL; Lião, LM; Menegatti, R; Mourão, AA; Oliveira-Silva, I; Pedrino, GR; Silva, ON; Verli, H; Villavicencio, B; Xavier, CH | 1 |
| Barta, A; Cebova, M; Franova, S; Kosutova, M; Pechanova, O | 1 |
| Chen, HE; Huang, LT; Lin, IC; Lin, YJ; Sheen, JM; Tain, YL; Tsai, CC; Yu, HR | 1 |
| Chen, JX; Deng, ZJ; Gan, L; Jiang, W; Lan, J; Li, H; Li, LY; Li, RL; Li, X; Tong, MM; Wang, XL; Wang, XX; Xin, JJ; Xue, KY; Yan, X; Zhang, HY; Zhuo, CL | 1 |
| Cai, GW; Cheng, P; Ding, L; Gao, S; Hu, J; Huang, GY; Wang, L; Zhang, YX | 1 |
| Contreras, D; Herrera, N; Perusquía, M | 1 |
| Bergamaschi, CT; Campos, RR; Cespedes, JG; Garcia, ML; Higa, EMS; Nishi, EE; Nogueira, FN; Pontes, RB; Zambrano, LI | 1 |
| Andrews, D; Bass, V; Gilmour, MI; King, C; Kodavanti, UP; Krantz, QT; Ledbetter, AD; Nyska, A; Richards, JE; Schladweiler, MC; Thomas, RF | 1 |
| Abdalla, FH; Bagatini, MD; Baldissarelli, J; Belló-Klein, A; Cardoso, AM; Chaves, H; Costa, P; Fiorenza, AM; Fiorin, Fda S; Gonçalves, JF; Martins, CC; Mello, FF; Morsch, VM; Royes, LF; Schetinger, MR; Serres, JD | 1 |
| Fukamizu, A; Ishida, J; Matsukura, T; Nagano, K; Unno, M | 1 |
| Bahrami, A; Farsi, L; Kamran, M; Keshavarz, M; Soltani, N | 1 |
| Aires, MB; Araujo, AJ; Fioretto, ET; Mota, MM; Santana-Filho, VJ; Santos, AC; Santos, MR; Souza, Kdos S | 1 |
| Bachmann, S; Bernstein, KE; Delpire, E; Eladari, D; Fletcher, NK; Fuchs, S; Giani, JF; Gonzalez-Villalobos, RA; Janjoulia, T; McDonough, AA; Navar, LG; Nguyen, MT; Peti-Peterdi, J; Picard, N; Riquier-Brison, AD; Seth, DM | 1 |
| Bryan, RM; Crossland, RF; Lloyd, EE; Marrelli, SP; Pandit, LM | 1 |
| Boehm, M; Cortese-Krott, MM; Gladwin, MT; Kato, GJ; Kelm, M; Kovacic, JC; Liu, VB; Noguchi, A; Raghavachari, N; Wang, X; Wood, KC | 1 |
| Bkaily, G; Brochu, I; D'Orléans-Juste, P; Desbiens, L; Gobeil, F; Houde, M; Semaan, W; Simard, E | 1 |
| Adamcova, M; Ruzickova, S; Simko, F | 1 |
| Govindasamy, C; Mustapha, Z; Nik Yusoff, NS; Sirajudeen, KN | 1 |
| Selamoglu Talas, Z | 1 |
| Török, J; Zemancíková, A | 1 |
| Bós, Dda S; Dillenburg, DR; Duarte, AA; Ferreira, D; Irigoyen, MC; Moraes-Silva, IC; Mostarda, C; Rigatto, K | 1 |
| Abdulla, MH; Abdullah, NA; Ahmad, Fu; Chia, TY; Johns, EJ; Kaur, G; Rathore, HA; Sattar, MA | 1 |
| Aziz, M; Bellahcen, S; Bnouham, M; Hakkou, Z; Legssyer, A; Mekhfi, H; Ziyyat, A | 1 |
| Khonsung, P; Lohcharoenkal, W; Manosroi, A; Manosroi, J; Manosroi, W | 1 |
| Baban, B; Brinson, KN; Crislip, GR; Elmarakby, AA; Sullivan, JC; Tipton, AJ; Yamamoto, T | 1 |
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| Coelho-Filho, OR; Jerosch-Herold, M; Kwong, R; Mitchell, R; Moreno, H; Neilan, TG; Shah, RV | 1 |
| Bernstein, KE; Blackwell, WL; Delpire, E; Fuchs, S; Giani, JF; Gonzalez-Villalobos, RA; Janjulia, T; Kamat, N; McDonough, AA; Seth, DM; Shah, KH; Shen, XZ; Toblli, JE | 1 |
| Hasegawa, Y; Katayama, T; Kim-Mitsuyama, S; Koibuchi, N; Ma, M; Maeda, M; Nakagawa, T; Ogawa, H; Sueta, D; Toyama, K; Uekawa, K; Waki, H | 1 |
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| Kumar, S; Prahalathan, P; Raja, B | 3 |
| Carvalho, FU; dos Santos, MR; Garcez, FB; Goes, TC; Soares, AP; Teixeira-Silva, F | 1 |
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| da Cunha, NV; de Andrade, FG; Goessler, KF; Karlen-Amarante, M; Martins-Pinge, MC; Polito, MD | 1 |
| Calabró, V; Fraga, CG; Galleano, M; Piotrkowski, B | 1 |
| Dai, J; Duan, X; Ji, W; Jiang, X; Liu, S; Wu, Y; Yang, T | 1 |
| Chan, JY; Hsu, CN; Huang, LT; Lee, CT; Tain, YL | 1 |
| Flavahan, NA; Flavahan, S; Leung, SW; Vanhoutte, PM; Xu, A; Zhao, Y | 1 |
| Chibbar, R; Ndisang, JF | 1 |
| Huang, LT; Lee, CT; Tain, YL | 1 |
| Chatterjee, S; Krishna Priya, M; Manivannan, J; Raja, B; Silambarasan, T; Suganya, N | 1 |
| Berger, JM; Brégeon, J; Calderon, C; Cariou, B; Hadchouel, J; Le May, C; Loirand, G; Prieur, X; Vaillant, N | 1 |
| Arcaya, JL; Chávez, M; Correia, D; Fernández, A; Finol, E; Pérez, M; Rincón, J; Romero, F; Summer, R; Talavera, E; Yaguas, K | 1 |
| Brouwers, S; Dupont, AG; Smolders, I; Wainford, RD | 1 |
| Chan, JY; Huang, LT; Lee, CT; Tain, YL | 1 |
| Arola-Arnal, A; Bravo, FI; Margalef, M; Muguerza, B; Pons, Z | 1 |
| Abdalla, FH; Bagatini, MD; Cardoso, AM; Jaques, JA; Leal, DB; Martins, CC; Morsch, VM; Schetinger, MR; Schmatz, R; Zanini, D | 1 |
| Kruyer, A; Norris, EH; Soplop, N; Strickland, S | 1 |
| Bernstein, KE; Li, L; Li, Y; Lyden, P; Shah, KH; Shen, XZ; Shi, P | 1 |
| Gao, JY; Ma, J; Ren, J; Wang, Q; Xiong, L; Xu, X; Yang, J; Yang, L | 1 |
| Araújo, JE; Bonjardim, LR; Fontes, MT; Mota, MM; Oliveira Carvalho, V; Santos, MR; Silva, TL | 1 |
| Bidani, AK; Bisla, R; Griffin, KA; Licea-Vargas, H; Long, J; Picken, M; Polichnowski, AJ; Williamson, GA | 1 |
| Basralı, F; Koçer, G; Nasırcılar Ülker, S; Özen, N; Özyurt, D; Satı, L; Şentürk, ÜK; Ülker Karadamar, P | 1 |
| Berkban, T; Boonprom, P; Bunbupha, S; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Prachaney, P; Welbat, JU | 1 |
| Bernstein, KE; Giani, JF; Gonzalez-Villalobos, RA; Han, J; Janjulia, T; McDonough, AA; Rodriguez-Iturbe, B; Shen, XZ; Toblli, JE | 1 |
| Alp Yildirim, FI; Balci Ekmekçi, Ö; Demirci Tansel, C; Eker Kizilay, D; Ergin, B; Kucur, M; Topal, G; Uydeş Doğan, BS | 1 |
| Pertijs, J; Rongen, GA; Thijs, AM; van den Broek, PH; van der Graaf, WT; van Herpen, CM; Verweij, V | 1 |
| Boonla, O; Donpunha, W; Kukongviriyapan, U; Kukongviriyapan, V; Pannangpetch, P; Sae-Eaw, A; Sripui, J | 1 |
| Bunbupha, S; Kukongviriyapan, U; Kukongviriyapan, V; Pakdeechote, P; Prachaney, P; Welbat, JU | 1 |
| Agüero, J; Almenar, L; Buendía, F; DʼOcon, P; Ivorra, MD; Montó, F; Muedra, V; Noguera, MA; Oliver, E; Rovira, E; Rueda, J; Valldecabres, C; Vicente, D | 1 |
| Aires, RD; Cortes, SF; Lemos, VS; Olivon, VC; Ramalho, LZ; Santiago, LB | 1 |
| Bernstein, EA; Bernstein, KE; Giani, JF; Harrison, DG; Janjulia, T; Li, Y; Shah, KH; Shen, XZ; Shi, P; Zhao, T | 1 |
| Kumar, S; Manivannan, J; Mishra, SK; Prahalathan, P; Raja, B; Saravanakumar, M; Silambarasan, T | 1 |
| Aronovitz, M; Bender, SB; Hill, MA; Hong, K; Jaffe, IZ; Jaisser, F; Mueller, KB; Yang, Y | 1 |
| Biwer, LA; D'Souza, KM; Hale, TM; Madhavpeddi, L; Ramaiah, P; Shahid, W | 1 |
| Basralı, F; Cengiz, M; Koçer, G; Nasırcılar Ülker, S; Özyurt, D; Şentürk, ÜK; Ülker Karadamar, P | 1 |
| Azman, A; Foong, WD; Jaarin, K; Juliana, AH; Kamarul, ZY; Kamisah, Y; Qodriyah, HM; Yeoh, MH; Zuhair, JS | 1 |
| Chen, L; Gao, XM; Geng, X; Li, CX; Liu, F; Ma, YK; Mao, HP; Qiu, LZ; Qu, JT; Wang, H; Yang, Y; Zhang, DX; Zhang, JM | 1 |
| Cribbs, DH; Gillen, DL; Kilday, K; Passos, GF; Vasilevko, V | 1 |
| Agar, A; Aras, S; Basrali, F; Kocer, G; Nasircilar Ulker, S; Ozsoy, O; Ozyurt, D; Senturk, UK; Ulker Karadamar, P; Yargicoglu, P | 1 |
| Braga, FC; Cortes, SF; Lemos, VS; Silva, GC | 1 |
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| Chatterjee, S; Manivannan, J; Raja, B; Silambarasan, T | 1 |
| Barbaro, NR; Bernstein, KE; Chen, W; Dale, BL; Foss, JD; Harrison, DG; Itani, HA; Kirabo, A; Madhur, MS; Mallal, SA; Montaniel, KR; Navar, LG; Norlander, AE; Pilkinton, MA; Saleh, MA; Sato, R; Wu, J; Xiao, L | 1 |
| Allagnat, F; Bérard, X; Corpataux, JM; Déglise, S; Haefliger, JA; Lambelet, M; Longchamp, A; Mazzolai, L | 1 |
| Cechinel-Filho, V; Conceição-Filho, G; Fregoneze, JB; Jesus, AM; Niero, H; Niero, R; Petreanu, M; Ribeiro, TS; Silva, AQ; Silva, DF; Simões, LO; Tamanaha, MS | 1 |
| Fahim, M; Hussain, ME; Pasha, S; Seth, MK | 1 |
| Akinyemi, AJ; Baldissarelli, J; Belló-Klein, A; Bottari, NB; de Oliveira, LS; Goularte, JF; Morsch, VM; Oboh, G; Schetinger, MR; Thomé, GR | 1 |
| Cheng, TL; Hu, CC; Lin, YY; Su, CT; Yang, AL | 1 |
| Aslan, M; Olgar, Y; Ozdemir, S; Ozturk, N | 1 |
| Kwiatkowski, P; Nowiński, A; Żera, T | 1 |
| Chan, JY; Hsu, CN; Lee, CT; Tain, YL | 1 |
| Bencsik, P; Brockhoff, B; Ferdinandy, P; Forst, S; Heger, J; Kiss, K; Schlüter, KD; Schreckenberg, R; Schulz, R | 1 |
| Altoama, K; Betti, E; Desfontis, JC; Mallem, MY; Thorin, C | 1 |
| Gayen, JR; Gupta, AP; Hanif, K; Kumar, S; Lahiri, S; Maurya, R; Mohan, D; Riyazuddin, M; Syed, AA; Valicherla, GR | 1 |
| Fu, J; Han, Y; Jose, PA; Liu, Y; Wang, J; Zeng, C; Zheng, S; Zhou, L | 1 |
| Bernstein, EA; Bernstein, KE; Eriguchi, M; Fuchs, S; Giani, JF; Gonzalez-Villalobos, RA; Katsumata, M; Li, L; McDonough, AA; Shen, XZ | 1 |
| Bergamaschi, CT; Campos, RR; Carvalho, PO; Franco, MD; Garcia, ML; Ibuki, FK; Nishi, EE; Nogueira, FN; Oliveira, V; Oyama, LM; Pontes, RB; Sawaya, AC | 1 |
| Bai, YP; Ren, Z; Tan, Z; Tang, H; Tang, YB; Xiao, S; Yang, Z; Zeng, H | 1 |
| Abdullah, HI; Durdagi, S; Duruyurek, M; Ekhteiari Salmas, R; Gulhan, MF; Selamoglu, Z | 1 |
| D'Ocon, P; Montó, F; Muedra, V; Oliver, E; Rovira, E; Valldecabres, C | 1 |
| Adamcova, M; Aziriova, S; Baka, T; Hodosy, J; Krajcirovicova, K; Mojto, V; Paulis, L; Repova, K; Simko, F; Slavkovsky, P; Zorad, S | 1 |
| Cho, JY; Choi, SY; Jeong, MH; Jin, L; Kee, HJ; Kim, GR; Lin, MQ; Piao, ZH; Ryu, Y; Sun, S | 1 |
| Koçer, G; Şentürk, ÜK; Ülker, SN | 1 |
| Panahi, N; Sargazi Zadeh, G | 1 |
| Ashpole, N; Csiszar, A; Fulop, GA; Gautam, T; Giles, CB; Sonntag, WE; Springo, Z; Tarantini, S; Ungvari, Z; Valcarcel-Ares, NM; Wren, JD; Yabluchanskiy, A | 1 |
| De Mey, JG; Janssen, B; Lemkens, P; Meens, MJ; Nelissen, J; Peters, SL; Schiffers, PM; Spijkers, LJ | 1 |
| Aboutabl, ME; El Din, AG; Kenawy, SA; Maklad, YA; Raafat, M | 1 |
| Blanco, JH; Maida, KD; Silveira, LC; Souza, HC; Tezini, GC | 1 |
| Arraj, M; Lemmer, B | 1 |
| Behuliak, M; Celec, P; Hojna, S; Kojsova, S; Kunes, J; Paulis, L; Pechanova, O; Simko, F; Zicha, J | 1 |
| Laurent, D; Pomposiello, S; Sari-Sarraf, F | 1 |
| Rossi, MA | 1 |
| Kasal, DA; Mandarim-de-Lacerda, CA; Neves, MF; Oigman, W | 1 |
| Ishizawa, K; Izawa, Y; Kagami, S; Kanematsu, Y; Kawazoe, K; Kondo, S; Motobayashi, Y; Ohnishi, H; Tamaki, T; Tomita, S; Tsuchiya, K; Yamaguchi, K | 1 |
| Aramburu, O; Arias, JL; Mate, A; Miguel-Carrasco, JL; Monserrat, MT; Vázquez, CM | 1 |
| Bay-Karabulut, A; Burma, O; Deniz, E; Sahna, E | 1 |
| Chen, HI; Hsieh, NK; Liu, DD; Yang, YL | 1 |
| Chen, JR; Yang, HY | 1 |
| Elkins, R; Sathishkumar, K; Yallampalli, C; Yallampalli, U | 1 |
| Alonso, MJ; Padilha, AS; Peçanha, FM; Salaices, M; Vassallo, DV | 1 |
| Brown, RD; Carlström, M; Lai, EY; Ma, Z; Patzak, A; Persson, AE | 1 |
| Bernatova, I; Kopincova, J; Puzserova, A | 2 |
| Akashiba, A; Ishimitsu, T; Matsuoka, H; Ono, H; Ono, Y | 1 |
| Bravo, Y; Chavez, M; Johnson, RJ; Parra, G; Pons, H; Quiroz, Y; Rodriguez-Iturbe, B; Salazar, J | 1 |
| Abdel-Aziz, H; Bahgat, A; El-Khatib, AS; Ismail, A; Khayyal, MT; Mahdy, A; Raafat, M | 1 |
| Akhtar, J; Dattani, ID; Desai, KM; Gopalakrishnan, V; Mishra, RC; Quest, D; Tripathy, S | 1 |
| Randall, MD; Wheal, AJ | 1 |
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| Török, J | 2 |
| Bubolz, AH; Ge, ZD; Gutterman, DD; Li, R; Mendoza, SA; Mizuno, A; Suzuki, M; Warltier, DC; Zhang, DX | 1 |
| Ecelbarger, CM; Rash, A; Riazi, S; Sharma, N; Tiwari, S | 1 |
| Blanco, JH; Cesarino, EJ; Di Sacco, TH; Jacinto, CP; Mazer, D; Rossi, BR; Silveira, LC; Souza, HC | 1 |
| Benova, M; Herichova, I; Krajcirovicova, K; Paulis, L; Simko, F; Stebelova, K; Zeman, M | 1 |
| Adigun, SA; Anigbogu, CN; Mojiminiyi, FB; Sofola, OA | 2 |
| Champlain, Jd; Couture, R; deBlois, D; Huot-Marchand, JE; Pilon, M; Wu, R | 1 |
| Calò, LA; Davis, PA; Mormino, P; Savica, V | 1 |
| Chadjichristos, C; Chatziantoniou, C; Dussaule, JC; Flamant, M; François, H; Guerrot, D; Helle, F; Jouzel, C; Placier, S | 1 |
| Dimo, T; Dongmo, AB; Kamanyi, A; Legssyer, A; Mekhfi, H; Nguelefack, TB; Watcho, P; Ziyyat, A; Zoheir, J | 1 |
| Cozza, IC; De Araújo, JE; Martins-Dias, DP; Martins-Pinge, MC; Souza, HC | 1 |
| Dyer, JL; McMillen, IC; Morrison, JL; Warnes, KE | 1 |
| Balfagón, G; del Campo, L; Ferrer, M | 1 |
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| Pechanova, O; Simko, F | 1 |
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| Bariskaner, H; Gökbel, H; Okudan, N; Sahin, AS | 1 |
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| Hejcl, A; Kunes, J; Sedy, J; Syková, E; Zicha, J | 1 |
| de Urbina, AV; Martín, ML; Morán, A; Rodríguez-Barbero, A; Román, LS | 1 |
| Cheung, L; Cosgrove, D; Delimont, D; Holzclaw, JD; Meehan, DT; Rao, V; Sansom, SC; Zallocchi, M | 1 |
| Aziz, M; Belmokhtar, M; Bnouham, M; Bouanani, NE; Fischmeister, R; Legssyer, A; Matéo, P; Mekhfi, H; Ziyyat, A | 1 |
| Chaudhary, K; Fadel, PJ; Fisher, JP; Gallagher, KM; Thomas, GD; Victor, RG; Whaley-Connell, A; Young, CN | 1 |
| Guo, F; Hay, M; Johnson, AK; Singh, M; Xue, B | 1 |
| O'Rourke, ST; Qian, SY; Sun, C; Yao, F; Zhang, Q | 1 |
| Cho, HS; Kim, WK; Lee, J; Park, S | 1 |
| Carneiro, FS; Giachini, FR; Inscho, EW; Lima, VV; Osmond, DA; Tostes, RC; Webb, RC; Zhang, S | 1 |
| Angulo, O; Ebrahimian, T; Marchesi, C; Paradis, P; Schiffrin, EL | 1 |
| Drummond, GR; Harrison, CB; Selemidis, S; Sobey, CG | 1 |
| McLemore, GR; Ryan, MJ; Stec, DE; Storm, MV; Vera, T | 1 |
| da Silva, CA; Dos Santos, FM; Fazan, R; Martins Dias, DP; Salgado, HC | 1 |
| Ahishali, B; Arican, N; Bilgic, B; Elmas, I; Kalayci, R; Kaya, M; Küçük, M; Uzun, H | 1 |
| Byku, M; Macarthur, H; Westfall, TC | 1 |
| Dobešová, Z; Jendeková, L; Kunes, J; Pecháňová, O; Pintérová, M; Vranková, S; Zicha, J | 1 |
| Agrawal, KC; Chandra, S; Dewitt, SY; Gur, S; Gurkan, L; Harbin, A; Hellstrom, WJ; Kadowitz, PJ; Sikka, SC | 1 |
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| Daneshtalab, N; Smeda, JS | 1 |
| Iliescu, R; Lopez-Ruiz, AF; Reckelhoff, JF | 1 |
| Cassis, LA; Daugherty, A; Guo, Z; McNamara, CA; Moorleghen, JJ; Owens, AP; Subramanian, V | 1 |
| Andriantsitohaina, R; Javorková, V; Mézesová, L; Pechánová, O; Vlkovicová, J; Vrbjar, N | 1 |
| Barta, A; Celec, P; Gardlik, R; Kunes, J; Paulis, L; Pechanova, O; Simko, F; Zicha, J | 1 |
| Gao, S; Kim, SH; Kim, SY; Kim, SZ; Park, BH; Shah, A; Yu, J; Yuan, K | 1 |
| Lee, SD; Lin, KL; Lo, CW; Su, CT; Yang, AL; Yeh, CK | 1 |
| Bakker, EN; Brewster, LM; de Vos, J; Matlung, HL; Quax, PH; Seghers, L; Taherzadeh, Z; van Montfrans, G; VanBavel, E | 1 |
| Burnstock, G; Gur, S; Hellstrom, WJ; Knight, GE; Sikka, SC | 1 |
| Huber, M; Kossmehl, P; Kreutz, R; Nyengaard, JR; Schulte, L; Schulz, A; Schütten, S; Vetter, R | 1 |
| Bishop, N; Cipolla, MJ; Godfrey, JA; Vinke, RS | 1 |
| Artyushkova, EB; Belous, AS; Kochkarov, VI; Pashin, EN; Pokrovskaya, TG; Pokrovskii, MV; Zhavbert, ES | 1 |
| Artyushkova, EB; Belous, AS; Brusnik, MS; Danilenko, LM; Kochkarov, VI; Korokin, MV; Korokina, LV; Malykhin, VA; Pashin, EN; Pokrovskaya, TG; Pokrovskii, MV; Zaloznykh, YI; Zhavbert, ES | 1 |
| Barron, C; Mandala, M; Osol, G | 1 |
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| Mate, A; Miguel-Carrasco, JL; Monserrat, MT; Vázquez, CM | 1 |
| da Silva Torres, T; de Carvalho, JJ; Mandarim-de-Lacerda, CA; Neto-Ferreira, R; Novaes Rocha, V | 1 |
| Castillo, C; Castillo, EF; Castillo, MC; López, RM; Pérez, T | 1 |
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| Bernabeu, E; Bertera, F; Bramuglia, GF; Buontempo, F; Chiappetta, D; Di Verniero, CA; Höcht, C; Mayer, MA; Taira, CA | 1 |
| di Stolfo, G; Dragoni, S; Gori, T; Lisi, M; Liuni, A; Luca, MC; Mariani, JA; Parker, JD; Uxa, A | 1 |
| Dikalov, S; Dikalova, AE; Góngora, MC; Griendling, KK; Harrison, DG; Lambeth, JD | 1 |
| Barreto-Chaves, ML; Bogo, MR; Bonan, CD; Casali, EA; Fürstenau, CR; Gossenheimer, AN; Monteiro, Pde S; Ramos, DB; Sarkis, JJ; Trentin, Dda S; Vuaden, FC; Wofchuk, ST | 1 |
| Berger, S; Duan, SZ; Frieler, RA; Ivaschenko, CY; Lumeng, CN; Mortensen, RM; Schütz, G; Usher, MG | 1 |
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| Atucha, NM; Eleno, N; Fortepiani, LA; García-Estañ, J; López-Novoa, JM; Martínez-Salgado, C; Ortiz, MC | 1 |
| Baskurt, OK; Bor-Kucukatay, M; Hacioglu, G; Ozkaya, G; Yalcin, O | 1 |
| Holtz, J; Jäger, D; Müller, SP; Müller-Werdan, U; Pönicke, K; Werdan, K | 1 |
| Anderson, CR; Chrissobolis, S; Chu, Y; Faraci, FM; Sobey, CG; Ziogas, J | 1 |
| Chang, HR; Chen, HI; Lee, RP; Wu, CY | 1 |
| Ago, T; Fujishima, M; Ibayashi, S; Kamouchi, M; Kitazono, T; Ooboshi, H; Santa, N | 1 |
| Colella, S; Frati, G; Fratta, L; Lembo, G; Maffei, A; Poulet, R; Trimarco, B; Trimarco, V; Vecchione, C | 1 |
| Brown, NJ; Fogo, AB; Kaikita, K; Painter, CA; Ripley, RT; Schoenhard, JA; Vaughan, DE | 1 |
| Demir, N; Ergüler, G; Erkiliç, M; Kuru, O; Sentürk, UK; Yeşilkaya, A | 1 |
| Bernard, C; Briot, F; Chevet, D; Lecour, S; Maupoil, V; Moisant, M; Rochette, L; Touchard, G; Zahnd, JP | 1 |
| Arican, N; Cimen, V; Elmas, I; Kalayci, R; Kaya, M; Korkut, F; Kucuk, M; Kudat, H | 1 |
| Finckenberg, P; Korhonen, H; Korpela, R; Nurminen, ML; Pihlanto-Leppälä, A; Sipola, M; Vapaatalo, H | 1 |
| Morikawa, E; Moskowitz, MA; Rosenblatt, S | 1 |
| Carretero, OA; Ito, S | 1 |
| Freeman, RH; Johnson, RA | 1 |
| Lahera, V; Romero, JC; Salazar, J; Salom, MG | 1 |
| Cowley, AW; Fenoy, FJ; Mattson, DL; Roman, RJ | 1 |
| Hamilton, CA; Huang, YT; Reid, JL | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA; Moncada, S; Palmer, RM | 1 |
| Arnal, JF; Michel, JB; Warin, L | 1 |
| Saxena, PR; Van Gelderen, EM | 1 |
| Antunes, E; de Nucci, G; Lovisolo, SM; Ribeiro, MO; Zatz, R | 1 |
| Tabrizchi, R; Triggle, CR | 1 |
| Gairard, A; Pernot, F; Schleiffer, R; Van Overloop, B | 1 |
29 review(s) available for ng-nitroarginine methyl ester and Blood Pressure, High
| Article | Year |
|---|---|
Participation of nitric oxide in different models of experimental hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Hypertension; Hypertriglyceridemia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Wistar; Sodium Chloride, Dietary; Stress, Psychological; Sympathetic Nervous System | 2008 |
Protective importance of the myogenic response in the renal circulation.
Topics: Animals; Disease Models, Animal; Female; Glomerular Filtration Rate; Homeostasis; Hypertension; Male; Nephrosclerosis; NG-Nitroarginine Methyl Ester; Primary Prevention; Proteinuria; Random Allocation; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Renal Circulation; Sensitivity and Specificity; Vascular Patency | 2009 |
Chronic antioxidant therapy fails to ameliorate hypertension: potential mechanisms behind.
Topics: Animals; Antioxidants; Cyclic GMP; Humans; Hypertension; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species | 2009 |
Dietary nitrite ameliorates renal injury in L-NAME-induced hypertensive rats.
Topics: Animals; Diet; Hypertension; Kidney Diseases; NG-Nitroarginine Methyl Ester; Rats; Sodium Nitrite | 2010 |
[Elements for the effective evaluation of natural products with possible antihypertensive effects].
Topics: Animals; Antihypertensive Agents; Aorta; Biological Products; Blood Pressure; Disease Models, Animal; Drug Evaluation, Preclinical; Hypertension; Medicine, Traditional; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Phytotherapy; Plant Preparations; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Renin-Angiotensin System; Vascular Resistance; Vasodilator Agents; Ventricular Remodeling | 2009 |
Salt-induced hemodynamic regulation mediated by nitric oxide.
Topics: Animals; Blood Pressure; Calcium Channel Blockers; Desoxycorticosterone; Endothelial Cells; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary | 2011 |
Animal models for the study of arterial hypertension.
Topics: Animals; Denervation; Diet; Disease Models, Animal; Humans; Hypertension; Hypertension, Renal; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pressoreceptors; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Transgenic | 2011 |
L-NAME in the cardiovascular system - nitric oxide synthase activator?
Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Time Factors | 2012 |
Role of sensory nervous system vasoactive peptides in hypertension.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Cells, Cultured; Desoxycorticosterone; Disease Models, Animal; Female; Hypertension; Mice; Mice, Knockout; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Pregnancy; Rats; Rats, Inbred SHR; Sensory Receptor Cells; Substance P | 2002 |
Protective role of endothelial nitric oxide synthase.
Topics: Animals; Arginine; Arteriosclerosis; Caveolin 1; Caveolins; Dimerization; Endothelium; Enzyme Inhibitors; Gene Transfer Techniques; Graft Rejection; Humans; Hypertension; Inflammation; Mice; Mice, Knockout; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Polymorphism, Genetic; Reperfusion Injury | 2003 |
Renal kallikrein-kinin system damage and salt sensitivity: insights from experimental models.
Topics: Animals; Enzyme Inhibitors; Hypertension; Kallikrein-Kinin System; Kidney; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Proteinuria; Sodium Chloride | 2003 |
Altered balance of vasoactive systems in experimental hypertension: the role of relative NO deficiency.
Topics: Age Factors; Animals; Calcium; Calcium Channels; Female; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Reactive Oxygen Species; Salts; Sex Factors | 2004 |
Nitric oxide and tubulointerstitial nephritides.
Topics: Animals; Biomarkers; Chronic Disease; Disease Models, Animal; Humans; Hypertension; Mice; Mice, Transgenic; Nephritis, Interstitial; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prognosis; Severity of Illness Index | 2004 |
[NO and atherosclerosis].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Arginine; Arteriosclerosis; Endothelium, Vascular; Enzyme Inhibitors; Genetic Therapy; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Probucol; Risk Factors; Stress, Mechanical | 2004 |
Nitric oxide pathway as new drug targets for refractory hypertension.
Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Endothelium, Vascular; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Signal Transduction; Superoxides | 2005 |
[Hypertensive organ injuries in spontaneously hypertensive rats given N(G)-nitro-L-arginine methyl ester].
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Cardiovascular System; Disease Models, Animal; Hypertension; Kidney; Life Style; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Renin-Angiotensin System; Risk Factors | 2006 |
Beneficial effects of Provinols: cardiovascular system and kidney.
Topics: Animals; Aortic Diseases; Blood Pressure; Cardiovascular System; Cyclosporine; Flavonoids; Humans; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Phenols; Polyphenols; Vasodilation; Wine | 2006 |
Analogy of cardiac and renal complications in essential hypertension and aged SHR or L-NAME/SHR.
Topics: Aging; Animals; Antihypertensive Agents; Disease Models, Animal; Enzyme Inhibitors; Heart Diseases; Hypertension; Kidney Diseases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR | 2007 |
Sex differences in oxidative stress and the impact on blood pressure control and cardiovascular disease.
Topics: Acetophenones; Animals; Antioxidants; Ascorbic Acid; Blood Pressure; Cardiovascular Diseases; Catalase; Cyclic N-Oxides; Enzyme Inhibitors; Female; Glutathione Peroxidase; Humans; Hypertension; Kidney; Male; Molsidomine; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Inbred SHR; Sex Factors; Spin Labels; Superoxide Dismutase; Vitamin E | 2007 |
Participation of nitric oxide in the regulation of renal function: possible role in the genesis of arterial hypertension.
Topics: Animals; Arginine; Feedback; Humans; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Renin; Vasodilation | 1994 |
Vascular structure in NG-nitro-L-arginine methyl ester-induced hypertension: methodological considerations for studies of small arteries in hypertension.
Topics: Animals; Arginine; Arteries; Humans; Hypertension; Microscopy, Video; Myography; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pressure | 1995 |
The potential role of nitric oxide in angiotensin II-receptor blockade.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Humans; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Receptors, Angiotensin | 1996 |
Nitric oxide: biological and clinical perspectives.
Topics: Animals; DNA; Humans; Hypertension; In Vitro Techniques; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Vasodilator Agents | 1996 |
Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Disease Susceptibility; Humans; Hypertension; Hypertrophy; Hypertrophy, Left Ventricular; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY | 1997 |
Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links.
Topics: Animals; Arteriosclerosis; Carotid Artery, External; Endothelium, Vascular; Humans; Hypertension; Mice; Mice, Knockout; Models, Genetic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Vasodilator Agents | 1999 |
Endothelium-derived nitric oxide and vascular physiology and pathology.
Topics: Animals; Arginine; Arteriosclerosis; Blood Vessels; Caveolin 1; Caveolins; Cell Adhesion; Endothelium, Vascular; Enzyme Induction; Enzyme Inhibitors; Humans; Hypertension; Hypertension, Pulmonary; Isoenzymes; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; omega-N-Methylarginine; Oxidative Stress; Rabbits; Signal Transduction; Vascular Diseases; Vasodilation | 1999 |
Endothelin: role in experimental hypertension.
Topics: Angiotensin II; Animals; Desoxycorticosterone; Disease Models, Animal; Endothelin-1; Fructose; Hypertension; Insulin Resistance; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred Dahl; Rats, Inbred SHR | 2000 |
Role of nitric oxide in central sympathetic outflow.
Topics: Animals; Cardiac Output, Low; Central Nervous System; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; RNA, Messenger; Sympathetic Nervous System | 2001 |
Effect of renal medullary circulation on arterial pressure.
Topics: Animals; Arginine; Blood Pressure; Diuresis; Hypertension; Kidney Medulla; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Sodium; Water-Electrolyte Balance | 1992 |
5 trial(s) available for ng-nitroarginine methyl ester and Blood Pressure, High
| Article | Year |
|---|---|
Systemic inhibition of nitric oxide synthesis in non-diabetic individuals produces a significant deterioration in glucose tolerance by increasing insulin clearance and inhibiting insulin secretion.
Topics: Adult; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Female; Glucose Clamp Technique; Glucose Intolerance; Glucose Tolerance Test; Humans; Hyperglycemia; Hypertension; Infusions, Intravenous; Insulin; Insulin Antagonists; Insulin Secretion; Insulin-Secreting Cells; Male; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Single-Blind Method; Young Adult | 2013 |
Effects of L-arginine and L-NAME on the renal function in hypertensive and normotensive subjects.
Topics: Adult; Arginine; Blood Glucose; Blood Pressure; Enzyme Inhibitors; Female; Hemodynamics; Humans; Hypertension; Insulin; Kidney; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Renin; Single-Blind Method; Time Factors; Vasoconstrictor Agents | 2002 |
Role of angiotensin II in L-NAME-induced systemic and renal hemodynamic effects in hydrochlorothiazide-pretreated hypertensive subjects.
Topics: Angiotensin II; Antihypertensive Agents; Diuresis; Diuretics; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Hormones; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuresis; NG-Nitroarginine Methyl Ester; Renal Circulation; Sodium Chloride Symporter Inhibitors | 2003 |
[Vasodilator effect of nitric oxide is a necessary counter-regulation in the spontaneously hypertensive rat].
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Body Weight; Cyclic GMP; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1993 |
Control of vascular tone in isolated mesenteric arterial segments from hypertensive patients.
Topics: Adult; Aged; Aged, 80 and over; Calcimycin; Calcium Channel Blockers; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Middle Aged; Muscle Tonus; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nifedipine; Norepinephrine; Potassium; Serotonin; Vasoconstrictor Agents | 1999 |
1084 other study(ies) available for ng-nitroarginine methyl ester and Blood Pressure, High
| Article | Year |
|---|---|
Galangin alleviates vascular dysfunction and remodelling through modulation of the TNF-R1, p-NF-κB and VCAM-1 pathways in hypertensive rats.
Topics: Amlodipine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Antioxidants; Blood Pressure; Flavonoids; Hypertension; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Receptors, Tumor Necrosis Factor, Type I; Vascular Cell Adhesion Molecule-1; Vascular Remodeling | 2021 |
Fig (Ficus exasperata and Ficus asperifolia)-Supplemented diet improves sexual function, endothelial nitric oxide synthase and suppresses tumour necrosis factor-alpha genes in hypertensive rats.
Topics: Animals; Blood Pressure; Diet; Ficus; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Tumor Necrosis Factor-alpha | 2022 |
Hexahydrocurcumin ameliorates hypertensive and vascular remodeling in L-NAME-induced rats.
Topics: Animals; Blood Pressure; Curcumin; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Vascular Remodeling | 2022 |
Evaluation of Oxidative Stress Biomarkers, Pro-Inflammatory Cytokines, and Histological Changes in Experimental Hypertension, Dyslipidemia, and Type 1 Diabetes Mellitus.
Topics: Animals; Biomarkers; Cytokines; Diabetes Mellitus, Type 1; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Hypertension; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Streptozocin; Sulfhydryl Compounds | 2022 |
Influence of uncomplicated, controlled hypertension on local heat-induced vasodilation in nonglabrous skin across the body.
Topics: Adult; Enzyme Inhibitors; Female; Hot Temperature; Humans; Hypertension; Male; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Regional Blood Flow; Skin; Vasodilation | 2022 |
Effect of
Topics: Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Blood Pressure; Hypertension; NG-Nitroarginine Methyl Ester; Plant Extracts; Prostaglandin-Endoperoxide Synthases; Rats; Vasodilator Agents | 2022 |
Antihypertensive effect of Mali-Nil surin rice bran hydrolysate and its mechanisms related to the EDHF-mediated vasorelaxation and L-type Ca
Topics: Animals; Antihypertensive Agents; Antioxidants; Biological Factors; Blood Pressure; Hypertension; Male; Mali; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oryza; Rats; Thailand; Vasoconstriction; Vasodilation | 2022 |
A novel endothelium-independent effect of insulin on basal vascular tone in cafeteria diet-induced hypertensive rats.
Topics: Animals; Diet; Endothelium, Vascular; Hypertension; Insulin; Male; Metabolic Syndrome; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Vasodilation | 2022 |
The effect of acute intradermal administration of ascorbate on heat loss responses in older adults with uncomplicated controlled hypertension.
Topics: Aged; Antioxidants; Ascorbic Acid; Female; Heat-Shock Response; Humans; Hypertension; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Skin; Sweating; Vasodilation | 2022 |
Antihypertensive effect and the underlying mechanisms of action of phytolaccagenin in rat models.
Topics: Animals; Antihypertensive Agents; Atropine Derivatives; Blood Pressure; Endothelium, Vascular; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Vasodilation | 2022 |
Homoarginine treatment of rats improves cardiac function and remodeling in response to pressure overload.
Topics: Animals; Blood Pressure; Heart Failure; Homoarginine; Hypertension; Lisinopril; Male; Myocardium; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Spironolactone; Ventricular Remodeling | 2022 |
Antihypertensive Activity of Prunus armeniaca in Hypertensive Rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Hypertension; NG-Nitroarginine Methyl Ester; Plant Extracts; Prunus armeniaca; Rats; Vasodilator Agents | 2023 |
Anti-inflammatory, anti-oxidant and cardio-protective properties of novel fluorophenyl benzimidazole in L-NAME-induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Benzimidazoles; Blood Pressure; Hypertension; Inflammation; Lipids; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Wistar | 2022 |
Nitric oxide synthase inhibition reveals differences in the nitric oxide pathway in previously laminitic ponies.
Topics: Animals; Blood Pressure; Dermatitis; Horse Diseases; Horses; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase | 2022 |
Time restricted feeding decreases renal innate immune cells and blood pressure in hypertensive mice.
Topics: Animals; Blood Pressure; Fasting; Hypertension; Immunity, Innate; Inflammation; Kidney; Mice; NG-Nitroarginine Methyl Ester | 2022 |
Moringa seed-supplemented diets modulate ACE activity but not its gene expression in L-NAME-induced hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Antioxidants; Arginase; Blood Pressure; Diet; Gene Expression; Hypertension; Moringa; NF-E2-Related Factor 2; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Rutin; Seeds | 2022 |
Composite biscuits from sandpaper and acha flour restore the altered activity of arginase, cholinergic, and purinergic enzymes in hypertensive-diabetic rats.
Topics: Animals; Arginase; Cholinergic Agents; Cholinesterases; Diabetes Mellitus, Experimental; Flour; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats | 2022 |
Activation of TRPV1 improves natriuresis and salt sensitivity in high-fat diet fed mice.
Topics: Animals; Diet, High-Fat; Hypertension; Mice; Mice, Knockout; Natriuresis; NG-Nitroarginine Methyl Ester; Sodium; Sodium Chloride; TRPV Cation Channels | 2022 |
Hypertension secondary to nitric oxide depletion produces oxidative imbalance and inflammatory/fibrotic outcomes in the cornea of C57BL/6 mice.
Topics: Animals; Biomarkers; Collagen; Cornea; Fibrosis; Hypertension; Mice; Mice, Inbred C57BL; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Reactive Oxygen Species | 2022 |
The antihypertensive and diuretic effect of crude root extract and saponins from Solanum sisymbriifolium Lam., in L-NAME-induced hypertension in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Diuretics; Enalapril; Female; Hypertension; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Saponins; Solanum | 2022 |
Saluisn-β contributes to endothelial dysfunction in monocrotaline-induced pulmonary arterial hypertensive rats.
Topics: Acetylcholine; Animals; Antioxidants; Disease Models, Animal; Hypertension; Hypertension, Pulmonary; Immunoglobulin G; Monocrotaline; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Superoxides | 2022 |
Early Development of Cardiac Fibrosis in Young Old-Father Offspring.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Blood Pressure; Fathers; Female; Fibrosis; Humans; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Transforming Growth Factor beta2 | 2022 |
Restoration of Mitochondrial Function Is Essential in the Endothelium-Dependent Vasodilation Induced by Acacetin in Hypertensive Rats.
Topics: Adenosine Triphosphate; Angiotensin II; Animals; Blood Pressure; Endothelium, Vascular; Flavones; Hypertension; Hypotension; Mitochondria; Mitochondrial Permeability Transition Pore; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptidyl-Prolyl Isomerase F; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Vasodilation | 2022 |
Hydroxychloroquine reduces hypertension and soluble fms-like kinase-1 in a Nω-nitro-l-arginine methyl ester-induced preeclampsia rat model.
Topics: Animals; Blood Pressure; Endothelial Cells; Endothelin-1; Female; Hydroxychloroquine; Hypertension; NG-Nitroarginine Methyl Ester; Placenta; Pre-Eclampsia; Pregnancy; Proteinuria; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species | 2022 |
Genetically inducing renal lymphangiogenesis attenuates hypertension in mice.
Topics: Animals; Doxycycline; Female; Hypertension; Kidney; Lymphangiogenesis; Male; Mice; NG-Nitroarginine Methyl Ester; Sodium | 2022 |
Topics: Animals; Antihypertensive Agents; Hypertension; NG-Nitroarginine Methyl Ester; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Vasodilator Agents | 2023 |
Maternal exposure to glyphosate-based herbicide causes changes in the vascular function of offspring adult rats.
Topics: Acetylcholine; Animals; Blood Pressure; Endothelium, Vascular; Female; Glyphosate; Herbicides; Humans; Hypertension; Maternal Exposure; NG-Nitroarginine Methyl Ester; Phenylephrine; Pregnancy; Rats; Rats, Wistar; Sodium Oxybate | 2023 |
L-Tartaric Acid Exhibits Antihypertensive and Vasorelaxant Effects: The Possible Role of eNOS/NO/cGMP Pathways.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Plant Extracts; Rats; Rats, Wistar; Vasodilator Agents | 2023 |
Antihypertensive Effect of
Topics: Angiotensin-Converting Enzyme 2; Animals; Antihypertensive Agents; Euphorbia; Hypertension; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Vasodilator Agents | 2023 |
Co-administration of metformin and/or glibenclamide with losartan reverse N
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Experimental; Esters; Glyburide; Hypertension; Hypoglycemic Agents; Losartan; Metformin; NG-Nitroarginine Methyl Ester; Rats; Streptozocin; Water | 2023 |
Antihypertensive action of Launaea taraxacifolia and its molecular mechanism of action.
Topics: Animals; Antihypertensive Agents; Antioxidants; Asteraceae; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Sodium | 2022 |
Resveratrol improved kidney function and structure in malignantly hypertensive rats by restoration of antioxidant capacity and nitric oxide bioavailability.
Topics: Animals; Antioxidants; Biological Availability; Blood Pressure; Hypertension; Hypertension, Malignant; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Inbred SHR; Resveratrol | 2022 |
Antioxidant-rich
Topics: Angiotensins; Animals; Antihypertensive Agents; Antioxidants; Arginase; Fruit; Hypertension; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Sildenafil Citrate; Terminalia | 2023 |
The renal resistive index is associated with microvascular remodeling in patients with severe obesity.
Topics: Albuminuria; Humans; Hypertension; Kidney; Microcirculation; NG-Nitroarginine Methyl Ester; Obesity; Obesity, Morbid; Vascular Resistance | 2023 |
Angelica decursiva exerts antihypertensive activity by inhibiting L-type calcium channel.
Topics: Angelica; Animals; Antihypertensive Agents; Calcium Channels, L-Type; Ethanol; HEK293 Cells; Humans; Hypertension; Mice; NG-Nitroarginine Methyl Ester; Plant Extracts | 2023 |
Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats.
Topics: Animals; Antihypertensive Agents; Atropine Derivatives; Blood Pressure; Hypertension; Indomethacin; Lipids; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Rats; Receptors, Muscarinic; RNA, Messenger | 2023 |
Limonin ameliorates cardiovascular dysfunction and remodeling in hypertensive rats.
Topics: Animals; Blood Pressure; Hypertension; Limonins; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2023 |
1,8-Cineole ameliorates endothelial injury and hypertension induced by L-NAME through regulation of autophagy via PI3K/mTOR signaling pathway.
Topics: Animals; Autophagy; Eucalyptol; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphatidylinositol 3-Kinases; Rats; Signal Transduction; TOR Serine-Threonine Kinases | 2023 |
Acute nitric oxide synthase inhibition induces greater increases in blood pressure in female versus male Wistar Kyoto rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Female; Hypertension; Hypotension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred WKY | 2023 |
Cardiomodulatory and Antioxidative Potentials of Almond-Citrus Peel Fortified Shortbread in High Fat Diet/L-NAME-Induced Hyperlipidemic-Hypertensive Rats.
Topics: Animals; Antioxidants; Arginase; Citrus; Diet, High-Fat; Dietary Supplements; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptidyl-Dipeptidase A; Prunus dulcis; Rats | 2023 |
Kaempferol protects against cardiovascular abnormalities induced by nitric oxide deficiency in rats by suppressing the TNF-α pathway.
Topics: Animals; Antioxidants; Aorta; Blood Pressure; Cardiovascular Abnormalities; Hypertension; Hypertrophy; Kaempferols; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphatidylinositol 3-Kinases; Rats; Tumor Necrosis Factor-alpha | 2023 |
Correlational Study of Aminopeptidase Activities between Left or Right Frontal Cortex versus the Hypothalamus, Pituitary, Adrenal Axis of Spontaneously Hypertensive Rats Treated with Hypotensive or Hypertensive Agents.
Topics: Aminopeptidases; Animals; Blood Pressure; Captopril; Frontal Lobe; Hypertension; Hypothalamus; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR | 2023 |
Pathogenic role of innate immunity in a model of chronic NO inhibition associated with salt overload.
Topics: Allopurinol; Animals; Enzyme Inhibitors; Hypertension; Immunity, Innate; Interleukin-1beta; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; NLR Family, Pyrin Domain-Containing 3 Protein; Pyrrolidines; Rats; Rats, Wistar; Renal Insufficiency, Chronic; Signal Transduction; Sodium Chloride, Dietary; Thiocarbamates; Toll-Like Receptor 4 | 2019 |
Peristrophe roxburghiana leaf extracts exhibited anti-hypertensive and anti-lipidemic properties in L-NAME hypertensive rats.
Topics: Acanthaceae; Animals; Antihypertensive Agents; Blood Pressure; Hypertension; Hypolipidemic Agents; Lipids; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Plant Extracts; Plant Leaves; Rats, Wistar | 2019 |
The Effects of Irisin on Nω-Nitro-L-arginine Methyl Ester Hydrochloride-Induced Hypertension in Rats
Topics: Analysis of Variance; Animals; Blood Pressure; Disease Models, Animal; Fibronectins; Hypertension; Male; NG-Nitroarginine Methyl Ester; Oxidative Stress; Rats; Rats, Sprague-Dawley; Turkey | 2019 |
The Role of the Activation of the TRPV1 Receptor and of Nitric Oxide in Changes in Endothelial and Cardiac Function and Biomarker Levels in Hypertensive Rats.
Topics: Animals; Biomarkers; Biopterins; Blood Pressure; Capsaicin; Drug Evaluation, Preclinical; Heart; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; TRPV Cation Channels; Vascular Resistance | 2019 |
Virgin rice bran oil alleviates hypertension through the upregulation of eNOS and reduction of oxidative stress and inflammation in L-NAME-induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Disease Models, Animal; Hypertension; Inflammation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Sprague-Dawley; Rice Bran Oil; Up-Regulation | 2020 |
Aqueous Extract of Matricaria pubescens Exhibits Antihypertensive Activity in L-NAME-induced Hypertensive Rats through its Vasorelaxant Effect.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Hypertension; Male; Matricaria; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats, Wistar; Vasodilator Agents | 2019 |
Vaccine Targeted Alpha 1D-Adrenergic Receptor for Hypertension.
Topics: Animals; Biopsy, Needle; China; Disease Models, Animal; Down-Regulation; Hypertension; Immunohistochemistry; Kidney Function Tests; Male; Molecular Targeted Therapy; NG-Nitroarginine Methyl Ester; Random Allocation; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Vaccines | 2019 |
Topics: Animals; Antihypertensive Agents; Asteraceae; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; KATP Channels; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Vasodilation | 2020 |
Effect of low dose L-NAME pretreatment on nitric oxide/reactive oxygen species balance and vasoactivity in L-NAME/salt-induced hypertensive rats.
Topics: Animals; Heart Ventricles; Hypertension; Kidney; Male; Mesenteric Arteries; NADPH Oxidase 2; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats, Inbred WKY; Reactive Oxygen Species; Sodium Chloride, Dietary | 2019 |
Central EP3 (E Prostanoid 3) Receptors Mediate Salt-Sensitive Hypertension and Immune Activation.
Topics: Adaptive Immunity; Analysis of Variance; Animals; Biomarkers; Biopsy, Needle; Brain; Dinoprostone; Disease Models, Animal; Female; Flow Cytometry; Hypertension; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Random Allocation; Real-Time Polymerase Chain Reaction; Receptors, Prostaglandin E, EP3 Subtype; Sodium, Dietary | 2019 |
Functional and neurometabolic asymmetry in SHR and WKY rats following vasoactive treatments.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Frontal Lobe; Humans; Hypertension; Male; NG-Nitroarginine Methyl Ester; Peptide Hydrolases; Propranolol; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2019 |
Reductions of Circulating Nitric Oxide are Followed by Hypertension during Pregnancy and Increased Activity of Matrix Metalloproteinases-2 and -9 in Rats.
Topics: Animals; Biomarkers; Blood Pressure; Enzyme Activation; Female; Gestational Age; Hypertension; Lipid Metabolism; Lipid Peroxidation; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Pregnancy; Pregnancy Complications, Cardiovascular; Rats | 2019 |
Role of Camellia brevistyla (Hayata) Coh. Stuart Seed Pomace Extract on Hypertension and Vascular Function in L-NAME-Treated Mice.
Topics: Animals; Antihypertensive Agents; Aorta; Arginine; Blood Pressure; Camellia; Carotid Intima-Media Thickness; Humans; Hypertension; Male; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Oxidative Stress; Plant Extracts; Seeds | 2019 |
Study of Antihypertensive Activity of Anvillea radiata in L-Name-Induced Hypertensive Rats and HPLC-ESI-MS Analysis.
Topics: Animals; Antihypertensive Agents; Asteraceae; Blood Pressure; Chromatography, High Pressure Liquid; Hypertension; Male; NG-Nitroarginine Methyl Ester; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Spectrometry, Mass, Electrospray Ionization | 2020 |
PPAR-γ agonist, pioglitazone, reduced oxidative and endoplasmic reticulum stress associated with L-NAME-induced hypertension in rats.
Topics: Animals; Antioxidants; Aorta; Blood Pressure; Catalase; Endoplasmic Reticulum Stress; Glutathione; Heart; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidation-Reduction; Oxidative Stress; Pioglitazone; PPAR gamma; Rats; Rats, Wistar; Superoxide Dismutase | 2019 |
Female Sex Is Protective in a Preclinical Model of Heart Failure With Preserved Ejection Fraction.
Topics: Animals; Blood Pressure; Diet, High-Fat; Disease Models, Animal; Enzyme Inhibitors; Female; Glucose Intolerance; Heart Failure; Humans; Hypertension; Male; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Obesity; Risk Factors; Sex Characteristics; Sex Factors; Stroke Volume; Ventricular Function, Left; Ventricular Remodeling; Weight Gain | 2019 |
Circulating Extracellular Vesicles in Normotension Restrain Vasodilation in Resistance Arteries.
Topics: Acetylcholine; Animals; Blood Pressure; Endothelium, Vascular; Extracellular Vesicles; Humans; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance; Vasodilation; Vasodilator Agents | 2020 |
Mathematical relationships of patterns of 35 rat haemodynamic parameters for conditions of hypertension resulting from decreased nitric oxide bioavailability.
Topics: Animals; Biological Availability; Blood Pressure; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; Models, Theoretical; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar | 2020 |
Cardiovascular Effects of Micromeria graeca (L.) Benth. ex Rchb in Normotensive and Hypertensive Rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; Lamiaceae; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Vasodilation | 2020 |
Antihypertensive Effect and Safety Evaluation of Rice Bran Hydrolysates from Sang-Yod Rice.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Female; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oryza; Oxidative Stress; Rats; Rats, Sprague-Dawley | 2020 |
Kidney-specific lymphangiogenesis increases sodium excretion and lowers blood pressure in mice.
Topics: Animals; Blood Pressure; Hypertension; Kidney; Lymphangiogenesis; Male; Mice; Mice, Transgenic; Natriuresis; NG-Nitroarginine Methyl Ester; Sodium; Sodium Chloride, Dietary; Vascular Endothelial Growth Factor D | 2020 |
The effect of curcuma (Curcuma xanthorrizha roxb.) extract as an adjuvant of captopril therapy on cardiac histopathology of male mice (Mus musculus) with hypertension.
Topics: Adjuvants, Pharmaceutic; Angiotensin-Converting Enzyme Inhibitors; Animals; Antioxidants; Captopril; Curcuma; Enzyme Inhibitors; Hypertension; Hypertrophy, Left Ventricular; Male; Mice; NG-Nitroarginine Methyl Ester; Plant Extracts; Treatment Outcome | 2020 |
Exercise training attenuates angiotensin II-induced vasoconstriction in the aorta of normotensive but not hypertensive rats.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Hypertension; Hypertension, Renovascular; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Physical Conditioning, Animal; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Vasoconstriction | 2020 |
Aortic remodeling is modest and sex-independent in mice when hypertension is superimposed on aging.
Topics: Aging; Angiotensin II; Animals; Aorta; Aorta, Abdominal; Aorta, Thoracic; Female; Hemodynamics; Hypertension; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Phenotype; Sodium Chloride, Dietary | 2020 |
Novel Insights into the Mode of Action of Vasorelaxant Synthetic Polyoxygenated Chalcones.
Topics: Animals; Aorta; Aorta, Thoracic; Cardiovascular Diseases; Chalcones; Endothelium, Vascular; Estrogen Receptor alpha; Female; Hypertension; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Vasodilation; Vasodilator Agents | 2020 |
Antihypertensive potential of cis-[Ru(bpy)
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Organometallic Compounds; Rats; Rats, Wistar; Ruthenium; Vasodilator Agents | 2020 |
Antioxidant and vasorelaxant effects of aqueous extract of large cardamom in L-NAME induced hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Antioxidants; Aorta; Arterial Pressure; Blood Vessels; Captopril; Elettaria; Hypertension; Hypertrophy; Kidney; Male; Malondialdehyde; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Vascular Remodeling; Vasodilation; Vasodilator Agents | 2020 |
Anti-lipidemic Effect of Fractions of Peristrophe bivalvis Leaf in NG-nitro-L-arginine Methyl Ester (L-NAME) Treated Rats.
Topics: Acanthaceae; Animals; Atherosclerosis; Blood Cell Count; Blood Pressure; Cholesterol, HDL; Cholesterol, LDL; Disease Models, Animal; Humans; Hypertension; Hypolipidemic Agents; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Triglycerides | 2020 |
Antihypertensive effect of Phragmanthera incana (Schum) Balle on NG-nitro-L-Arginine methyl ester (L-NAME) induced hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Arterial Pressure; Biomarkers; Captopril; Disease Models, Animal; Hypertension; Interleukin-6; Kidney; Lipid Peroxidation; Liver; Loranthaceae; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitrites; Oxidative Stress; Plant Extracts; Rats, Wistar; Tumor Necrosis Factor-alpha | 2020 |
Electrical stimulation of the carotid sinus lowers arterial pressure and improves heart rate variability in L-NAME hypertensive conscious rats.
Topics: Animals; Arterial Pressure; Baroreflex; Disease Models, Animal; Electric Stimulation Therapy; Heart Rate; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats, Wistar | 2020 |
Cutaneous sensory nerve-mediated microvascular vasodilation in normotensive and prehypertensive non-Hispanic Blacks and Whites.
Topics: Adolescent; Adult; Black People; Blood Pressure; Enzyme Inhibitors; Female; Humans; Hypertension; Male; Microdialysis; Microvessels; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Sensory Receptor Cells; Skin; United States; Vasodilation; Vasodilator Agents; White People; Young Adult | 2020 |
Antihypertensive power of Naringenin is mediated via attenuation of mineralocorticoid receptor (MCR)/ angiotensin converting enzyme (ACE)/ kidney injury molecule (Kim-1) signaling pathway.
Topics: Animals; Antihypertensive Agents; Brain; Cell Adhesion Molecules; Flavanones; Hypertension; Kidney; Male; Neurons; NG-Nitroarginine Methyl Ester; Oxidative Stress; Peptidyl-Dipeptidase A; Rats, Wistar; Receptors, Mineralocorticoid; Signal Transduction | 2020 |
Acetylcholinesterase inhibition prevents alterations in cardiovascular autonomic control and gastric motility in L-NAME-induced hypertensive rats.
Topics: Acetylcholinesterase; Animals; Arterial Pressure; Autonomic Nervous System; Baroreflex; Cardiovascular System; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Protective Agents; Pyridostigmine Bromide; Rats; Rats, Wistar; Stomach; Stroke Volume | 2020 |
Increased Blood Pressure Causes Lymphatic Endothelial Dysfunction via Oxidative Stress in Spontaneously Hypertensive Rats.
Topics: Acetylcholine; Animals; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Lymphatic Vessels; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 2020 |
Disparate Effect of Antioxidant Supplements on the Basal Tone and Vascular Remodeling of the Aorta in Hypertensive Rats.
Topics: Animals; Antioxidants; Aorta, Thoracic; Ascorbic Acid; Cyclic N-Oxides; Dietary Supplements; Disease Models, Animal; Glutathione; Hypertension; Male; Membrane Potentials; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Rats, Sprague-Dawley; Spin Labels; Vascular Remodeling; Vasoconstriction | 2020 |
Angiotensin converting enzyme inhibitor potentiates the hypoglycaemic effect of NG-nitro-L-arginine methyl ester (L-NAME) in rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Glucose; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Hypertension; Hypoglycemic Agents; Insulins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Prostaglandins I; Ramipril; Rats; Rats, Wistar | 2022 |
Low-dose L-NAME induces salt sensitivity associated with sustained increased blood volume and sodium-chloride cotransporter activity in rodents.
Topics: Animals; Blood Pressure; Blood Volume; Hypertension; Mice; NG-Nitroarginine Methyl Ester; Rats; Rodentia; Sodium Chloride Symporters | 2020 |
Ruta Montana Evokes Antihypertensive Activity Through an Increase of Prostaglandins Release in L-NAME-Induced Hypertensive Rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Male; NG-Nitroarginine Methyl Ester; Organ Culture Techniques; Plant Extracts; Prostaglandins; Rats; Rats, Wistar; Ruta; Vasodilation | 2021 |
Sodium thiosulfate improves renal function and oxygenation in L-NNA-induced hypertension in rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Rats; Rats, Sprague-Dawley; Thiosulfates | 2020 |
Endothelial cell prostaglandin E2 receptor EP4 is essential for blood pressure homeostasis.
Topics: Animals; Blood Pressure; Dinoprostone; Endothelial Cells; Endothelium, Vascular; Homeostasis; Hypertension; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Receptors, Prostaglandin E, EP4 Subtype | 2020 |
Endothelial ATP-Sensitive Potassium Channel Protects Against the Development of Hypertension and Atherosclerosis.
Topics: Animals; Antihypertensive Agents; Apolipoproteins E; Atherosclerosis; Blood Pressure; Diet, High-Fat; Endothelial Cells; Enzyme Inhibitors; Hypertension; KATP Channels; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Peptide Fragments; Pinacidil; Treatment Outcome; Vasodilation | 2020 |
Blood pressure-lowering effects of a Bowman-Birk inhibitor and its derived peptides in normotensive and hypertensive rats.
Topics: Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Chymotrypsin; Coronary Vessels; Enzyme Inhibitors; Hypertension; Male; Molecular Docking Simulation; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Peptides; Peptidyl-Dipeptidase A; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Rats; Rats, Inbred SHR; Rats, Wistar; Trypsin; Trypsin Inhibitor, Bowman-Birk Soybean; Vasodilation | 2020 |
Aqueous extract of oakmoss produces antihypertensive activity in L-NAME-induced hypertensive rats through sGC-cGMP pathway.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Arterial Pressure; Blood Pressure; Calcium Channel Blockers; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Glyburide; Hypertension; KATP Channels; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Parmeliaceae; Plant Extracts; Propranolol; Rats; Rats, Wistar; Resins, Plant; Terpenes; Vasodilator Agents | 2021 |
Effects of caffeine and caffeic acid on selected biochemical parameters in L-NAME-induced hypertensive rats.
Topics: Animals; Caffeic Acids; Caffeine; Hypertension; NG-Nitroarginine Methyl Ester; Rats | 2021 |
1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea (TPPU), a soluble epoxide hydrolase inhibitor, lowers L-NAME-induced hypertension through suppression of angiotensin-converting enzyme in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Animals; Epoxide Hydrolases; Hypertension; Male; NG-Nitroarginine Methyl Ester; Phenylurea Compounds; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1 | 2020 |
Antihypertensive and vasoprotective effects of Clausena lansium fruits extract in L-NAME induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Clausena; Disease Models, Animal; Fruit; Glutathione; Hypertension; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Plant Extracts; Protective Agents; Rats; Rats, Sprague-Dawley; Superoxides | 2020 |
Vasorelaxant and Antihypertensive Effects of Mentha pulegium L. in Rats: An In vitro and In vivo Approach.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Arterial Pressure; Calcium Channel Blockers; Calcium Signaling; Disease Models, Animal; Hypertension; Male; Mentha pulegium; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats, Wistar; Vasodilation; Vasodilator Agents | 2021 |
PKR inhibitor imoxin prevents hypertension, endothelial dysfunction and cardiac and vascular remodelling in L-NAME-treated rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; eIF-2 Kinase; Endothelium, Vascular; Hypertension; Imidazoles; Indoles; Male; NG-Nitroarginine Methyl Ester; Protein Kinase Inhibitors; Rats; Rats, Wistar; Vascular Remodeling; Vasodilation | 2020 |
Effect of Standardized Hydroalcoholic Extract of Saffron Stamen on High Blood Pressure and Baroreflex Sensitivity in Anesthetized Rats.
Topics: Anesthesia; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Cardiovascular System; Crocus; Ethanol; Flowers; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Reference Standards; Water | 2021 |
The Possible Regulatory Mechanisms of Aqueous, Ethyl Acetate and NHexane Fractions of the Ribes khorassanicum Extract on Acute Hypertension in Rats.
Topics: Acetates; Acute Disease; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Disease Models, Animal; Hexanes; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Ribes; Signal Transduction; Water | 2021 |
Cratoxylum formosum dyer extract alleviates testicular damage in hypertensive rats.
Topics: Animals; Blood Pressure; Clusiaceae; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley | 2021 |
Maternal tadalafil therapy for fetal growth restriction prevents non-alcoholic fatty liver disease and adipocyte hypertrophy in the offspring.
Topics: Adipocytes; Animals; Diet, High-Fat; Female; Fetal Development; Fetal Growth Retardation; Glucose Tolerance Test; Hypertension; Hypertrophy; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Non-alcoholic Fatty Liver Disease; Pregnancy; Prenatal Exposure Delayed Effects; Tadalafil | 2021 |
Inhibition of L-NAME-induced hypertension by combined treatment with apocynin and catalase: the role of Nox 4 expression.
Topics: Acetophenones; Animals; Antioxidants; Catalase; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; NADPH Oxidase 4; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred WKY; Reactive Oxygen Species | 2021 |
CRIP1 expression in monocytes related to hypertension.
Topics: Angiotensin II; Animals; Blood Pressure; Carrier Proteins; Cell Differentiation; Cohort Studies; Disease Models, Animal; Humans; Hypertension; Macrophages; Male; Monocytes; NG-Nitroarginine Methyl Ester; Spleen; Transcriptome | 2021 |
Cardiovascular effects of farnesol and its β-cyclodextrin complex in normotensive and hypertensive rats.
Topics: Animals; Arterial Pressure; beta-Cyclodextrins; Blood Pressure; Bradycardia; Cardiovascular Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Farnesol; Heart Rate; Hypertension; Male; Molecular Docking Simulation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar | 2021 |
Effect of Methanol Extract of Baobab (Adansonia digitata L.) Fruit Pulp on N
Topics: Adansonia; Animals; Antihypertensive Agents; Blood Pressure; Female; Fruit; Hypertension; Male; Methanol; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar | 2021 |
Protective role of the mitochondrial fusion protein OPA1 in hypertension.
Topics: Animals; Apoptosis; Enzyme Inhibitors; GTP Phosphohydrolases; Hypertension; Male; Mice, Inbred C57BL; Mice, Knockout; Mitochondrial Dynamics; NG-Nitroarginine Methyl Ester; Oxidative Stress; Protective Agents; Reactive Oxygen Species | 2021 |
Clitoria ternatea L. extract prevents kidney damage by suppressing the Ang II/Nox4/oxidative stress cascade in l-NAME-induced hypertension model of rats.
Topics: Angiotensin II; Animals; Clitoria; Hypertension; Kidney; NADPH Oxidase 4; NG-Nitroarginine Methyl Ester; Oxidative Stress; Plant Extracts; Rats; Rats, Sprague-Dawley | 2021 |
Interaction between Angiotensinase Activities in Pituitary and Adrenal Glands of Wistar-Kyoto and Spontaneously Hypertensive Rats under Hypotensive or Hypertensive Treatments.
Topics: Adrenal Glands; Animals; Antihypertensive Agents; Captopril; Endopeptidases; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hypertension; Hypotension; Male; NG-Nitroarginine Methyl Ester; Pituitary Gland; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2021 |
Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cytochrome P-450 CYP2D6; Disease Models, Animal; Heart Rate; Herb-Drug Interactions; Hypertension; Lepidium sativum; Metoprolol; NG-Nitroarginine Methyl Ester; Nigella sativa; Rats; Rats, Wistar; Trigonella | 2021 |
Roxadustat prevents Ang II hypertension by targeting angiotensin receptors and eNOS.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Cardiomegaly; Cells, Cultured; Electrolytes; Endothelial Cells; Glycine; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Isoquinolines; Kidney Glomerulus; Male; Mice; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Proteinuria; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Thiobarbituric Acid Reactive Substances; Urine; Vascular Remodeling | 2021 |
Renoprotective and therapeutic effects of newly water, ethanol, and butanol ginseng fractions in hypertensive and chronic kidney disease with L-NAME.
Topics: Animals; Butanols; Disease Models, Animal; Ethanol; Female; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Hypertension; Losartan; NG-Nitroarginine Methyl Ester; Panax; Plant Extracts; Rats; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha; Water | 2021 |
Negligible effect of eNOS palmitoylation on fatty acid regulation of contraction in ventricular myocytes from healthy and hypertensive rats.
Topics: Animals; Arginine; Disease Models, Animal; Fatty Acids; Heart Ventricles; Hypertension; Male; Myocardium; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxygen Consumption; Palmitic Acid; Rats; Rats, Sprague-Dawley | 2017 |
A Single Resistance Exercise Session Improves Aortic Endothelial Function in Hypertensive Rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blotting, Western; Endothelium, Vascular; Exercise Test; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Phenylephrine; Phosphorylation; Physical Conditioning, Animal; Prostaglandins; Random Allocation; Rats, Inbred SHR; Reference Values; Resistance Training; Time Factors; Vasoconstriction | 2017 |
Nitric oxide pathway presumably does not contribute to antianxiety and memory retrieval effects of losartan.
Topics: Angiotensins; Animals; Anti-Anxiety Agents; Behavior, Animal; Hypertension; Hypothalamo-Hypophyseal System; Imidazoles; Kidney; Losartan; Male; Memory; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Angiotensin; Soluble Guanylyl Cyclase | 2017 |
Enhanced endothelin-1/Rho-kinase signalling and coronary microvascular dysfunction in hypertensive myocardial hypertrophy.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arterioles; Cardiomegaly; Endothelin-1; Endothelium, Vascular; Hypertension; Male; Mice, Inbred C57BL; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; rho-Associated Kinases; Signal Transduction; Vasoconstriction; Vasodilator Agents | 2017 |
Aerobic Swim Training Restores Aortic Endothelial Function by Decreasing Superoxide Levels in Spontaneously Hypertensive Rats.
Topics: Animals; Aorta, Thoracic; Blotting, Western; Endothelium, Vascular; Ethidium; Exercise Test; Fluorescence; Hemodynamics; Hypertension; Male; NAD; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitrites; Physical Conditioning, Animal; Random Allocation; Rats, Inbred SHR; Reference Values; Reproducibility of Results; Superoxides; Swimming; Time Factors; Vasodilation | 2017 |
Effects of carvedilol or amlodipine on target organ damage in L-NAME hypertensive rats: their relationship with blood pressure variability.
Topics: Amlodipine; Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Blood Pressure Determination; Carbazoles; Carvedilol; Collagen; Disease Models, Animal; Fibrosis; Heart Ventricles; Humans; Hypertension; Interleukin-6; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; NG-Nitroarginine Methyl Ester; Propanolamines; Rats; Rats, Wistar; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha | 2017 |
Antihypertensive and vasodilator effects of methanolic extract of Inula viscosa: Biological evaluation and POM analysis of cynarin, chlorogenic acid as potential hypertensive.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Chlorogenic Acid; Cinnamates; Hypertension; Inula; Medicine, Traditional; Methanol; NG-Nitroarginine Methyl Ester; Phytochemicals; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Vasodilator Agents | 2017 |
Nebivolol alleviates aortic remodeling through eNOS upregulation and inhibition of oxidative stress in l-NAME-induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Arginine; Atenolol; Blood Pressure; Enzyme Inhibitors; Hypertension; Male; NADPH Oxidases; Nebivolol; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Rats, Sprague-Dawley; Reactive Oxygen Species; Up-Regulation; Vascular Remodeling | 2017 |
In vitro renin-angiotensin system inhibition and in vivo antihypertensive activity of peptide fractions from lima bean (Phaseolus lunatus L.).
Topics: Animals; Antihypertensive Agents; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Phaseolus; Plant Proteins; Rats; Rats, Wistar; Renin-Angiotensin System | 2018 |
Differential responses of mesenteric arterial bed to vasoactive substances in L-NAME-induced preeclampsia: Role of oxidative stress and endothelial dysfunction.
Topics: Acetylcholine; Angiotensin II; Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Female; Fetal Growth Retardation; Glutathione Peroxidase; Hypertension; Malondialdehyde; Mesentery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Oxidative Stress; Phenylephrine; Placenta; Pre-Eclampsia; Pregnancy; Protein Carbonylation; Rats; Superoxide Dismutase; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2018 |
Early Actions of Anti-Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor Receptor Drugs on Angiogenic Blood Vessels.
Topics: Adenoviridae; Angiogenesis Inhibitors; Animals; Bibenzyls; Blood Vessels; Cell Death; Cell Proliferation; Endothelial Cells; Female; Hypertension; Mice, Inbred C57BL; Mice, Nude; Microvessels; Models, Biological; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Receptors, Vascular Endothelial Growth Factor; Recombinant Fusion Proteins; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2017 |
Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Captopril; Disease Models, Animal; Fibrosis; Heart Ventricles; Hypertension; Light; Male; Melatonin; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Ventricular Remodeling | 2017 |
Potential Cardiovascular and Renal Protective Effects of Vitamin D and Coenzyme Q
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cardiovascular Diseases; Hypertension; Kidney Diseases; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Ubiquinone; Valsartan; Vitamin D; Vitamins | 2017 |
Parkia speciosa empty pod prevents hypertension and cardiac damage in rats given N(G)-nitro-l-arginine methyl ester.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiotonic Agents; Enzyme Inhibitors; Fabaceae; Fruit; Heart; Hypertension; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Sprague-Dawley | 2017 |
Bidens pilosa Ethylene acetate extract can protect against L-NAME-induced hypertension on rats.
Topics: Acetates; Animals; Bidens; Ethylenes; Hypertension; Kidney; Lipids; Liver; NG-Nitroarginine Methyl Ester; Oxidative Stress; Plant Extracts; Protective Agents; Rats, Wistar | 2017 |
Effect of 20-HETE inhibition on L-NAME-induced hypertension in rats.
Topics: Amidines; Animals; Blood Pressure; Enzyme Inhibitors; Hydroxyeicosatetraenoic Acids; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Tissue Culture Techniques; Vascular Resistance; Vasoconstriction; Vasodilation | 2018 |
Taurine enhances spermatogenic function and antioxidant defense mechanisms in testes and epididymis of L-NAME-induced hypertensive rats.
Topics: Animals; Antioxidants; Epididymis; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Spermatogenesis; Taurine; Testis | 2018 |
Nitric oxide production by glomerular podocytes.
Topics: Angiotensin II; Animals; Calcium Signaling; Glomerular Filtration Barrier; Hydrogen Peroxide; Hypertension; Kidney Glomerulus; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroso Compounds; Podocytes; Rats, Inbred Dahl; Sodium Chloride, Dietary | 2018 |
Diuretic and natriuretic effect of luteolin in normotensive and hypertensive rats: Role of muscarinic acetylcholine receptors.
Topics: Animals; Atropine; Blood Pressure; Calcium; Diuretics; Female; Hydrogen-Ion Concentration; Hypertension; Luteolin; Male; Natriuretic Agents; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Receptors, Muscarinic | 2017 |
Aliskiren and valsartan in combination is a promising therapy for hypertensive renal injury in rats.
Topics: Amides; Animals; Antihypertensive Agents; Blood Pressure; Blood Urea Nitrogen; Creatinine; Drug Therapy, Combination; Enzyme Inhibitors; Fumarates; Hypertension; Kidney; Kidney Diseases; Male; NG-Nitroarginine Methyl Ester; Oxidative Stress; Proteinuria; Rats; Rats, Wistar; Valsartan | 2018 |
Protective effect of the standardized leaf extract of Ginkgo biloba (EGb761) against hypertension-induced renal injury in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Cardiovascular Agents; Ginkgo biloba; Glutathione; Hypertension; Hypertension, Renal; Interleukin-1beta; Interleukin-6; Kidney; Kidney Diseases; Losartan; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Plant Extracts; Rats; Tumor Necrosis Factor-alpha | 2018 |
Contrasting effects of low versus high ascorbate doses on blood pressure responses to oral nitrite in L-NAME-induced hypertension.
Topics: Administration, Oral; Animals; Ascorbic Acid; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar | 2018 |
Effect of Melatonin on the Renin-Angiotensin-Aldosterone System in l-NAME-Induced Hypertension.
Topics: Animals; Blood Pressure; Hypertension; Male; Melatonin; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Renin-Angiotensin System | 2018 |
Apelin/APJ expression in the heart and kidneys of hypertensive rats.
Topics: Animals; Apelin; Apelin Receptors; Blotting, Western; Body Weight; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Hypertension; Immunohistochemistry; Kidney; Myocardium; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Reference Standards | 2018 |
Enhancing Renal Lymphatic Expansion Prevents Hypertension in Mice.
Topics: Animals; Antigens, Differentiation; Calcium-Binding Proteins; Cell Movement; Homeodomain Proteins; Hypertension; Kidney; Lymphangiogenesis; Lymphatic Vessels; Macrophages; Mice; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Organ Specificity; Receptors, G-Protein-Coupled; Sodium Chloride, Dietary; T-Box Domain Proteins; Th1 Cells; Tumor Suppressor Proteins; Vascular Endothelial Growth Factor D; Vascular Endothelial Growth Factor Receptor-3 | 2018 |
Inhibition of endothelial nitric oxide synthase reverses the effect of exercise on improving cognitive function in hypertensive rats.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Brain; Cognition; Cognitive Dysfunction; Hypertension; Insulin-Like Growth Factor I; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinases; Physical Conditioning, Animal; Proto-Oncogene Proteins c-akt; Rats, Inbred SHR; Rats, Inbred WKY | 2018 |
Beneficial Effects of Different Flavonoids on Vascular and Renal Function in L-NAME Hypertensive Rats.
Topics: Animals; Antihypertensive Agents; Apigenin; Flavonoids; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Random Allocation; Rats; Rats, Sprague-Dawley | 2018 |
Erythropoietin Protects the Kidney by Regulating the Effect of TNF-α in L-NAME-Induced Hypertensive Rats.
Topics: Animals; Darbepoetin alfa; Erythropoietin; Female; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Protective Agents; Rats; Receptors, Tumor Necrosis Factor, Type I; Receptors, Tumor Necrosis Factor, Type II; Tumor Necrosis Factor-alpha | 2018 |
Effects of oligomeric grape seed proanthocyanidins on L-NAME-induced hypertension in pregnant mice: Role of oxidative stress and endothelial dysfunction.
Topics: Animals; Aorta; Blood Pressure; Female; Grape Seed Extract; Heart; Hypertension; Kidney; Mice; NG-Nitroarginine Methyl Ester; Oxidative Stress; Pregnancy; Proanthocyanidins | 2018 |
[Effect and mechanism of three kinds of drinking water on blood pressure of hypertensive mice].
Topics: Animals; Blood Pressure; Drinking Water; Hypertension; Malondialdehyde; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide | 2017 |
Taurine Ameliorates Thyroid Hypofunction and Renal Injury in L-NAME-Induced Hypertensive Rats.
Topics: Animals; Antihypertensive Agents; Atenolol; Blood Pressure; Dietary Supplements; Disease Models, Animal; Humans; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Oxidative Stress; Rats; Rats, Wistar; Renal Insufficiency; Taurine; Thyroid Gland | 2019 |
The Probiotic Lactobacillus fermentum Prevents Dysbiosis and Vascular Oxidative Stress in Rats with Hypertension Induced by Chronic Nitric Oxide Blockade.
Topics: Animals; Blood Pressure; Dysbiosis; Endothelium, Vascular; Enzyme Inhibitors; Gastrointestinal Microbiome; Gene Expression Regulation; Hypertension; Limosilactobacillus fermentum; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Probiotics; Rats, Wistar | 2018 |
The Effect of Chronic NO Synthase Inhibition on the Vasoactive and Structural Properties of Thoracic Aorta, NO Synthase Activity, and Oxidative Stress Biomarkers in Young SHR.
Topics: Animals; Aorta, Thoracic; Biomarkers; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Vasodilation | 2018 |
Therapeutic potentials of propolis and pollen on biochemical changes in reproductive function of L-NAME induced hypertensive male rats.
Topics: Animals; Antihypertensive Agents; Aryldialkylphosphatase; Catalase; Hypertension; Male; Malondialdehyde; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidants; Pollen; Propolis; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Testis | 2019 |
ADMA, homocysteine and redox status improvement affected by 7-nitroindazole in spontaneously hypertensive rats.
Topics: Animals; Aorta; Arginine; Biomarkers; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Homocysteine; Hypertension; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidation-Reduction; Rats, Inbred SHR | 2018 |
Linoleic acid reduces vascular reactivity and improves the vascular dysfunction of the small mesentery in hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase 2; Hypertension; Linoleic Acid; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Oxidative Stress; Phenylephrine; Prostaglandins; Rats, Inbred SHR; Vascular Remodeling; Vasoconstriction; Vasodilation | 2018 |
Renoprotective Effects of Antroquinonol in Rats with N
Topics: Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Antrodia; Arginine; Arterioles; Biological Products; Biomarkers; Blood Pressure; Disease Models, Animal; Hypertension; Inflammation; Kidney; Kidney Diseases; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Oxidative Stress; Rats, Wistar; Ubiquinone | 2018 |
BJ-PRO-7A and BJ-PRO-10C induce vasodilatation and inotropic effects in normotensive and hypertensive rats: Role of nitric oxide and muscarinic receptors.
Topics: Adenylyl Cyclase Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptors, Muscarinic; Vasodilation; Viper Venoms | 2018 |
Physical exercise prevents memory impairment in an animal model of hypertension through modulation of CD39 and CD73 activities and A2A receptor expression.
Topics: 5'-Nucleotidase; Animals; Antigens, CD; Apyrase; Cerebral Cortex; Disease Models, Animal; Hypertension; Memory; NG-Nitroarginine Methyl Ester; Physical Conditioning, Animal; Rats; Receptor, Adenosine A2A; Swimming | 2019 |
Ivabradine does not impair anxiety-like behavior and memory in both healthy and L-NAME-induced hypertensive rats.
Topics: Animals; Anxiety; Blood Pressure; Enzyme Inhibitors; Heart Rate; Hypertension; Ivabradine; Male; Memory; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar | 2018 |
Moringa oleifera leaf extract lowers high blood pressure by alleviating vascular dysfunction and decreasing oxidative stress in L-NAME hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Catalase; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Malondialdehyde; Mesenteric Arteries; Moringa oleifera; NG-Nitroarginine Methyl Ester; Oxidative Stress; Plant Extracts; Rats, Wistar; Superoxide Dismutase; Vasodilation | 2019 |
Ivabradine reversed nondipping heart rate in rats with l-NAME-induced hypertension.
Topics: Animals; Circadian Rhythm; Heart Rate; Hypertension; Ivabradine; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Rest | 2019 |
Antihypertensive effects of the hydro-ethanol extract of Senecio serratuloides DC in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Ethanol; Female; Heart; Hypertension; Lipids; Mice; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Senecio | 2019 |
Nobiletin alleviates vascular alterations through modulation of Nrf-2/HO-1 and MMP pathways in l-NAME induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Blood Vessels; Collagen; Flavones; Heme Oxygenase (Decyclizing); Humans; Hypertension; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Muscle, Smooth, Vascular; NF-E2-Related Factor 2; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Signal Transduction | 2019 |
Connexin37-Dependent Mechanisms Selectively Contribute to Modulate Angiotensin II -Mediated Hypertension.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Connexins; Disease Models, Animal; Endothelial Cells; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Gap Junction alpha-4 Protein; Hypertension; Male; Mice; Mice, Knockout; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Myosin Light Chains; NG-Nitroarginine Methyl Ester; Protein Tyrosine Phosphatase, Non-Receptor Type 6; Proto-Oncogene Proteins c-akt; Receptor, Angiotensin, Type 2; Renin; Vasoconstrictor Agents | 2019 |
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Eucalyptus; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Plant Extracts; Rats, Wistar; Signal Transduction; Vasodilation; Vasodilator Agents | 2021 |
Novel choline analog 2-(4-((1-phenyl-1H-pyrazol-4-yl)methyl)piperazin-1-yl)ethan-1-ol produces sympathoinhibition, hypotension, and antihypertensive effects.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Atropine; Blood Pressure; Heart Rate; Hypertension; Hypotension; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperazines; Piperidines; Pirenzepine; Pyrazoles; Rats, Inbred SHR; Rats, Wistar; Receptor, Muscarinic M1; Receptor, Muscarinic M3 | 2019 |
Different adaptive NO-dependent Mechanisms in Normal and Hypertensive Conditions.
Topics: Adaptation, Physiological; Animals; Biomarkers; Blood Pressure; Body Weight; Cytokines; Enzyme Activation; Gene Expression; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Rats | 2019 |
Resveratrol prevents combined prenatal N
Topics: Animals; Diet, High-Fat; Discriminant Analysis; Enzyme Inhibitors; Female; Gastrointestinal Microbiome; Hypertension; Maternal Exposure; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nutrients; Oxidative Stress; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Rats; Rats, Sprague-Dawley; Resveratrol | 2019 |
5-Lipoxagenase deficiency attenuates L-NAME-induced hypertension and vascular remodeling.
Topics: Animals; Aorta; Arachidonate 5-Lipoxygenase; Blood Pressure; Cell Movement; Cell Proliferation; Hypertension; Leukotriene A4; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Vascular Remodeling | 2019 |
The protective effects of polysaccharide extract from Xin-Ji-Er-Kang formula on Ang II-induced HUVECs injury, L-NAME-induced hypertension and cardiovascular remodeling in mice.
Topics: Angiotensin II; Animals; Aorta; Arginine; Blood Pressure; Cytokines; Drug Evaluation, Preclinical; Drugs, Chinese Herbal; Endothelial Cells; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Inflammation; Male; Malondialdehyde; Mice; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phytotherapy; Superoxide Dismutase; Vascular Remodeling | 2019 |
Hypotestosteronemia is an important factor for the development of hypertension: elevated blood pressure in orchidectomized conscious rats is reversed by different androgens.
Topics: Androgens; Animals; Blood Pressure; Dihydrotestosterone; Drug Evaluation, Preclinical; Endothelin-1; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Orchiectomy; Rats, Inbred WKY; Rats, Wistar; Testosterone | 2019 |
Antihypertensive activity of Petroselinum crispum through inhibition of vascular calcium channels in rats.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Calcium Channel Blockers; Calcium Channels; Hypertension; Male; NG-Nitroarginine Methyl Ester; Petroselinum; Plant Components, Aerial; Plant Extracts; Rats, Wistar; Vasodilator Agents | 2019 |
Pattern of sympathetic vasomotor activity in a model of hypertension induced by nitric oxide synthase blockade.
Topics: Animals; Baroreflex; Blood Pressure; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Sympathetic Nervous System; Vasoconstriction | 2019 |
Diesel exhaust induced pulmonary and cardiovascular impairment: the role of hypertension intervention.
Topics: Albumins; Animals; Atherosclerosis; Cardiovascular Diseases; Hydralazine; Hypertension; Lung Diseases; Male; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Platelet Aggregation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vehicle Emissions | 2013 |
Swimming training prevents alterations in acetylcholinesterase and butyrylcholinesterase activities in hypertensive rats.
Topics: Acetylcholinesterase; Animals; Blood Pressure; Butyrylcholinesterase; Hypertension; Inflammation; Lymphocytes; Male; NG-Nitroarginine Methyl Ester; Physical Conditioning, Animal; Rats; Rats, Wistar; Swimming | 2014 |
Apelin elevates blood pressure in ICR mice with L‑NAME‑induced endothelial dysfunction.
Topics: Animals; Aorta; Blood Pressure; Body Weight; Endothelium, Vascular; Gene Expression Regulation; Hypertension; Intercellular Signaling Peptides and Proteins; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Systole; Vasoconstrictor Agents; Vasodilation | 2013 |
GABA-induced vasorelaxation mediated by nitric oxide and GABAA receptor in non diabetic and streptozotocin-induced diabetic rat vessels.
Topics: Animals; Blood Glucose; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; gamma-Aminobutyric Acid; Hypertension; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptors, GABA-A; Risk Factors; Vasodilation | 2013 |
Resistance training controls arterial blood pressure in rats with L-NAME- induced hypertension.
Topics: Analysis of Variance; Animals; Blood Pressure; Disease Models, Animal; Hypertension; Male; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitroprusside; Phenylephrine; Physical Conditioning, Animal; Random Allocation; Rats; Rats, Wistar; Resistance Training; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2013 |
The absence of intrarenal ACE protects against hypertension.
Topics: Angiotensin II; Animals; Hypertension; Kidney; Liver; Loop of Henle; Male; Mice; NG-Nitroarginine Methyl Ester; Peptidyl-Dipeptidase A; Protein Serine-Threonine Kinases; Receptors, Drug; Renin-Angiotensin System; Sodium; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1; Solute Carrier Family 12, Member 3; Symporters; Water | 2013 |
Endothelium-dependent relaxations in the aorta from K(2p)6.1 knockout mice.
Topics: Animals; Aorta, Thoracic; Calcimycin; Disease Models, Animal; Endothelium, Vascular; Hypertension; Indomethacin; Male; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Phenylephrine; Potassium Channels, Tandem Pore Domain; Vasoconstriction; Vasodilation | 2013 |
Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis.
Topics: Animals; Arginine; Blood Pressure; Carbon Radioisotopes; Citrulline; Endothelium, Vascular; Enzyme Inhibitors; Erythrocytes; Homeostasis; Hypertension; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Signal Transduction | 2013 |
High salt-induced hypertension in B2 knockout mice is corrected by the ETA antagonist, A127722.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Atrasentan; Disease Models, Animal; Endothelin A Receptor Antagonists; Endothelin-1; Female; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Peptides, Cyclic; Pyrrolidines; Receptor, Bradykinin B2; Sodium; Sodium Chloride, Dietary; Telemetry | 2013 |
Multiplexed immunoassays for simultaneous quantification of cardiovascular biomarkers in the model of H(G)-nitro-L-arginine methylester (L-NAME) hypertensive rat.
Topics: Animals; Biomarkers; Blood Pressure; Enzyme Inhibitors; Hypertension; Immunoassay; Male; Natriuretic Peptide, Brain; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Troponin I; Troponin T; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A | 2013 |
Effect of Clonidine (an antihypertensive drug) treatment on oxidative stress markers in the heart of spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Biomarkers; Blood Pressure; Clonidine; Heart; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Protein Carbonylation; Rats; Rats, Inbred SHR; Thiobarbituric Acid Reactive Substances | 2013 |
Propolis reduces oxidative stress in l-NAME-induced hypertension rats.
Topics: Animals; Bees; Catalase; Hypertension; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Propolis; Rats; Rats, Wistar; Testis | 2014 |
Diminished contractile responses of isolated conduit arteries in two rat models of hypertension.
Topics: Animals; Arteries; Disease Models, Animal; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Wistar; Vasoconstriction | 2013 |
Resveratrol and grape juice differentially ameliorate cardiovascular autonomic modulation in L-NAME-treated rats.
Topics: Animals; Autonomic Nervous System; Beverages; Cardiovascular System; Disease Models, Animal; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; NG-Nitroarginine Methyl Ester; Oxidation-Reduction; Rats; Rats, Wistar; Resveratrol; Stilbenes; Vasodilator Agents; Vitis | 2013 |
The effects of tempol on renal function and hemodynamics in cyclosporine-induced renal insufficiency rats.
Topics: Animals; Antioxidants; Blood Pressure; Cyclic N-Oxides; Cyclosporine; Disease Models, Animal; Hemodynamics; Hypertension; Kidney; Kidney Concentrating Ability; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Renal Insufficiency; Spin Labels; Superoxide Dismutase | 2013 |
Antidiabetic and antihypertensive effect of Virgin Argan Oil in model of neonatal streptozotocin-induced diabetic and l-nitroarginine methylester (l-NAME) hypertensive rats.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Glycogen; Hyperglycemia; Hypertension; Hypoglycemic Agents; Liver; NG-Nitroarginine Methyl Ester; Phytotherapy; Plant Oils; Rats; Rats, Wistar; Sapotaceae | 2013 |
Potent antihypertensive activity of Thai-Lanna medicinal plants and recipes from "MANOSROI III" database.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Databases, Factual; Disease Models, Animal; Heart Rate; Hypertension; Male; Medicine, Traditional; NG-Nitroarginine Methyl Ester; Phytotherapy; Plant Preparations; Plants, Medicinal; Rats; Rats, Sprague-Dawley; Thailand | 2013 |
Female SHR have greater blood pressure sensitivity and renal T cell infiltration following chronic NOS inhibition than males.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cell Adhesion Molecules; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Enzyme Inhibitors; Female; Hypertension; Inflammation; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Sex Factors; T-Lymphocytes; Time Factors | 2013 |
Quantification of cardiomyocyte hypertrophy by cardiac magnetic resonance: implications for early cardiac remodeling.
Topics: Algorithms; Animals; Aortic Valve Stenosis; Biomarkers; Body Water; Cardiomyopathy, Hypertrophic; Cell Size; Contrast Media; Gadolinium DTPA; Hypertension; Hypertrophy; Hypertrophy, Left Ventricular; Magnetic Resonance Imaging; Male; Mice; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Phenotype; Random Allocation; Ventricular Remodeling | 2013 |
Acute toxicity and vascular properties of seed of Parkia biglobosa (JACQ) R. Br Gift (Mimosaceae) on rat aorta.
Topics: Animals; Antihypertensive Agents; Aorta; Burkina Faso; Dose-Response Relationship, Drug; Endothelium, Vascular; Fabaceae; Hypertension; Indomethacin; Lethal Dose 50; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Phenylephrine; Phytotherapy; Plant Preparations; Prostaglandins; Rats; Rats, Wistar; Seeds; Vasoconstriction; Vasodilator Agents | 2012 |
The effects of atorvastatin on oxidative stress in L-NAME-treated rats.
Topics: Animals; Aryldialkylphosphatase; Atorvastatin; Drug Evaluation, Preclinical; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Lipid Peroxidation; Lipids; Male; NG-Nitroarginine Methyl Ester; Oxidative Stress; Protein Carbonylation; Pyrroles; Rats; Rats, Wistar; Sulfhydryl Compounds | 2013 |
Plasminogen activator inhibitor-1: a novel therapeutic target for hypertension?
Topics: Animals; Cellular Senescence; Female; Hypertension; Male; NG-Nitroarginine Methyl Ester; Serpin E2 | 2013 |
Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence.
Topics: Animals; Aorta; Blood Pressure; Cardiomegaly; Cellular Senescence; Drug Interactions; Enzyme Inhibitors; Female; Hypertension; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; para-Aminobenzoates; Piperazines; Rats; Rats, Wistar; Serpin E2; Structure-Activity Relationship; Telomere | 2013 |
Enantioselective pharmacokinetics and cardiovascular effects of nebivolol in L-NAME hypertensive rats.
Topics: Adrenergic beta-Antagonists; Animals; Area Under Curve; Benzopyrans; Blood Pressure; Chemistry, Pharmaceutical; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanolamines; Heart Rate; Hemodynamics; Hypertension; Injections, Intravenous; Male; Nebivolol; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Rats; Rats, Wistar; Stereoisomerism | 2014 |
Role of macrophage PPARγ in experimental hypertension.
Topics: Anilides; Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; CD36 Antigens; Hypertension; Macrophages; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; PPAR gamma; Thioglycolates; Up-Regulation | 2014 |
Aldehyde dehydrogenase 2 partly mediates hypotensive effect of nitrite on L-NAME-induced hypertension in normoxic rat.
Topics: Aldehyde Dehydrogenase; Aldehyde Dehydrogenase, Mitochondrial; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hydrazines; Hypertension; Male; Mitochondrial Proteins; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitroglycerin; Rats; Rats, Sprague-Dawley; Sodium Nitrite; Time Factors | 2014 |
Treatment with an extract of Terminalia superba Engler & Diels decreases blood pressure and improves endothelial function in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Blood Pressure; Cyclic N-Oxides; Drug Therapy, Combination; Endothelium, Vascular; Hypertension; Male; NG-Nitroarginine Methyl Ester; Plant Bark; Plant Extracts; Plant Stems; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels; Terminalia | 2014 |
Renoprotective effect of sitagliptin against hypertensive nephropathy induced by chronic administration of L-NAME in rats: role of GLP-1 and GLP-1 receptor.
Topics: Animals; Blood Glucose; Dipeptidyl-Peptidase IV Inhibitors; Glucagon-Like Peptide 1; Glucagon-Like Peptide-1 Receptor; Glutathione Peroxidase; Hypertension; Hypertension, Renal; Hypoglycemic Agents; Kidney; Lipid Peroxidation; Male; Nephritis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrazines; Rats; Rats, Wistar; Receptors, Glucagon; Sitagliptin Phosphate; Superoxide Dismutase; Triazoles | 2013 |
Renoprotective effects of melatonin in young spontaneously hypertensive rats with L-NAME.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Amidohydrolases; Animals; Antioxidants; Arginine; Blood Pressure; Deoxyguanosine; Humans; Hypertension; Hypertension, Renal; Kidney; Male; Melatonin; Nephritis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR | 2014 |
Damage-associated molecular pattern activated Toll-like receptor 4 signalling modulates blood pressure in L-NAME-induced hypertension.
Topics: Animals; Blood Vessels; Cyclic GMP; Hypertension; Inflammation; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Signal Transduction; Toll-Like Receptor 4 | 2014 |
Genetic variants on rat chromosome 8 exhibit profound effects on hypertension severity and survival during nitric oxide inhibition in spontaneously hypertensive rats.
Topics: Albuminuria; Animals; Blood Pressure; Chromosomes, Mammalian; Disease Models, Animal; Enzyme Inhibitors; Genetic Predisposition to Disease; Genetic Variation; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenotype; Quantitative Trait Loci; Rats; Rats, Inbred SHR; Severity of Illness Index; Time Factors | 2014 |
Involvement of BKCa and KV potassium channels in cAMP-induced vasodilatation: their insufficient function in genetic hypertension.
Topics: Adrenergic beta-Agonists; Animals; Blood Pressure; Cyclic AMP; Hypertension; Isoproterenol; Large-Conductance Calcium-Activated Potassium Channel alpha Subunits; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium Channels, Voltage-Gated; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance; Vasodilation | 2014 |
L-carnitine attenuates the development of kidney fibrosis in hypertensive rats by upregulating PPAR-γ.
Topics: Animals; Carnitine; Cells, Cultured; Collagen; Connective Tissue Growth Factor; Cytoprotection; Disease Models, Animal; Enzyme Inhibitors; Fibrosis; Hypertension; Inflammation Mediators; Interleukin-10; Interleukin-1beta; Interleukin-6; Kidney Diseases; Kidney Tubules, Proximal; Male; Membrane Glycoproteins; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; NG-Nitroarginine Methyl Ester; PPAR gamma; Rats; Rats, Wistar; Transforming Growth Factor beta1; Up-Regulation | 2014 |
Decreased endothelial nitric oxide, systemic oxidative stress, and increased sympathetic modulation contribute to hypertension in obese rats.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Obesity; Oxidative Stress; Rats; Rats, Wistar; Reactive Oxygen Species; Sodium Glutamate; Sympathetic Nervous System | 2014 |
Vascular xanthine oxidoreductase contributes to the antihypertensive effects of sodium nitrite in L-NAME hypertension.
Topics: Animals; Antihypertensive Agents; Endothelium, Vascular; Hypertension; Male; NG-Nitroarginine Methyl Ester; Random Allocation; Rats; Rats, Wistar; Sodium Nitrite; Xanthine Dehydrogenase | 2014 |
Valproic acid prevents the deregulation of lipid metabolism and renal renin-angiotensin system in L-NAME induced nitric oxide deficient hypertensive rats.
Topics: Animals; Antihypertensive Agents; Catalase; Glutathione; Glutathione Peroxidase; Hypertension; Hypolipidemic Agents; Kidney; Lipid Metabolism; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Peptidyl-Dipeptidase A; Rats, Wistar; Renin; Renin-Angiotensin System; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Valproic Acid | 2014 |
Asiatic acid reduces blood pressure by enhancing nitric oxide bioavailability with modulation of eNOS and p47phox expression in L-NAME-induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Biological Availability; Blood Pressure; Hemodynamics; Hypertension; Male; Malondialdehyde; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Superoxides | 2014 |
Heme oxygenase suppresses markers of heart failure and ameliorates cardiomyopathy in L-NAME-induced hypertension.
Topics: Adiponectin; Aldosterone; Animals; Antioxidants; Arginine; Atrial Natriuretic Factor; Biomarkers; Blood Pressure; Cardiomyopathies; Cardiotonic Agents; Chemokine CCL2; Chemokine CCL3; Cyclic GMP; Dinoprost; Endothelin-1; Enzyme Induction; Extracellular Matrix Proteins; Heart Failure; Heme; Heme Oxygenase (Decyclizing); Hypertension; Interleukin-1beta; Interleukin-6; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Tyrosine | 2014 |
Platelet activation patterns are different in mouse models of diabetes and chronic inhibition of nitric oxide synthesis.
Topics: Animals; Blood Platelets; CD40 Ligand; Diabetes Mellitus, Experimental; Hypertension; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; P-Selectin; Platelet Activation; Platelet Aggregation; Random Allocation; Thromboxane B2 | 2014 |
[Variability of plasma angiotensinogen levels and risk of hypertension in a transgenic rat model].
Topics: Angiotensinogen; Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Humans; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Transgenic | 2014 |
The antihypertensive effects of sodium nitrite are not associated with circulating angiotensin converting enzyme inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Male; NG-Nitroarginine Methyl Ester; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Sodium Nitrite; Structure-Activity Relationship | 2014 |
Changes in adrenoceptors and G-protein-coupled receptor kinase 2 in L-NAME-induced hypertension compared to spontaneous hypertension in rats.
Topics: Animals; Aorta; G-Protein-Coupled Receptor Kinase 2; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, beta-2; Vasoconstriction; Vasodilation | 2014 |
Enhanced vasoconstriction to α1 adrenoceptor autoantibody in spontaneously hypertensive rats.
Topics: Adrenergic alpha-1 Receptor Agonists; Animals; Aorta; Autoantibodies; Blotting, Western; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Humans; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Receptors, Adrenergic, alpha-1; Tyrosine; Vasoconstriction; Vasoconstrictor Agents | 2014 |
Cardiac magnetic resonance assessment of interstitial myocardial fibrosis and cardiomyocyte hypertrophy in hypertensive mice treated with spironolactone.
Topics: Animals; Cardiac Imaging Techniques; Cardiomegaly; Fibrosis; Heart; Hypertension; Magnetic Resonance Imaging; Mice; Myocardium; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Receptors, Mineralocorticoid; Spironolactone; Stroke Volume | 2014 |
Renal angiotensin-converting enzyme is essential for the hypertension induced by nitric oxide synthesis inhibition.
Topics: Angiotensin II; Animals; Blood Pressure; Glomerular Filtration Rate; Hypertension; Kidney; Male; Mice; Mice, Inbred C57BL; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Renin; Symporters | 2014 |
Blood pressure variability, impaired autonomic function and vascular senescence in aged spontaneously hypertensive rats are ameliorated by angiotensin blockade.
Topics: Aging; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Autonomic Nervous System; Baroreflex; beta-Galactosidase; Blood Pressure; Drug Evaluation, Preclinical; Endothelium, Vascular; Hypertension; Imidazoles; Myocardium; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Norepinephrine; Organ Size; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reflex, Abnormal; Renin-Angiotensin System; Tetrazoles; Valine; Valsartan; Vasodilation | 2014 |
Brain BDNF levels elevation induced by physical training is reduced after unilateral common carotid artery occlusion in rats.
Topics: Animals; Arterial Occlusive Diseases; Brain; Brain-Derived Neurotrophic Factor; Carotid Artery, Common; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Rats, Wistar | 2014 |
The hypotensive effect of the ruthenium complex [Ru(terpy)(bdq)NO]³⁺ is higher in male than in female spontaneously hypertensive rats (SHR).
Topics: Acetophenones; Animals; Blood Pressure; Cyclic N-Oxides; Female; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Organometallic Compounds; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Wistar; Sex Factors; Spin Labels | 2014 |
Hypotensive and antihypertensive potential of 4-[(1-phenyl-1H-pyrazol-4-yl) methyl]1-piperazine carboxylic acid ethyl ester: a piperazine derivative.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Aorta; Atropine; Baroreflex; Blood Flow Velocity; Blood Pressure; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Piperazines; Pyrazoles; Pyridines; Rats; Rats, Inbred SHR; Rats, Wistar; Tissue Culture Techniques; Vasodilation | 2014 |
Hypertension and hyperglycemia synergize to cause incipient renal tubular alterations resulting in increased NGAL urinary excretion in rats.
Topics: Acute-Phase Proteins; Animals; Biomarkers; Blood Pressure; Diabetes Mellitus, Experimental; Hyperglycemia; Hypertension; Kidney Tubules; Lipocalin-2; Lipocalins; Male; NG-Nitroarginine Methyl Ester; Perfusion; Proto-Oncogene Proteins; Rats, Inbred SHR; Rats, Wistar | 2014 |
Letter by Tsuda regarding article, "Plasminogen activator inhibitor-1 antagonist TM5441 attenuates Nω-nitro-L-arginine methyl ester-induced hypertension and vascular senescence".
Topics: Animals; Cellular Senescence; Female; Hypertension; Male; NG-Nitroarginine Methyl Ester; Serpin E2 | 2014 |
Different effects of 7-nitroindazole and L-NAME administered both individually and together on the cardiovascular system of the rat.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cardiomegaly; Carotid Arteries; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Hypertension; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats, Inbred SHR; Rats, Wistar; Vascular Remodeling; Vasodilation; Ventricular Remodeling | 2015 |
Antihypertensive activity of blueberries fermented by Lactobacillus plantarum DSM 15313 and effects on the gut microbiota in healthy rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blueberry Plants; Body Weight; Fermentation; Fruit; Gastrointestinal Microbiome; Heart; Hypertension; Kidney; Lactobacillus plantarum; Liver; Male; NG-Nitroarginine Methyl Ester; Organ Size; Phytotherapy; Plant Preparations; Probiotics; Rats; Rats, Sprague-Dawley; Spleen | 2015 |
Vanillic acid: a potential inhibitor of cardiac and aortic wall remodeling in l-NAME induced hypertension through upregulation of endothelial nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Gene Expression Regulation, Enzymologic; Hypertension; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Rats, Wistar; Vanillic Acid; Ventricular Function, Left | 2014 |
The influence of trait anxiety on the elevation of arterial pressure induced by L-NAME in rats.
Topics: Animals; Anxiety; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats, Wistar; Species Specificity | 2014 |
Effect of the antihypertensive drug enalapril on oxidative stress markers and antioxidant enzymes in kidney of spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Antioxidants; Biomarkers; Catalase; Enalapril; Enzyme Inhibitors; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Oxidative Stress; Rats; Rats, Inbred SHR; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances | 2014 |
Endothelin A receptor blocker atrasentan lowers blood pressure by the reduction of nifedipine-sensitive calcium influx in Ren-2 transgenic rats fed a high-salt diet.
Topics: Animal Feed; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Calcium; Calcium Channels, L-Type; Captopril; Endothelin A Receptor Antagonists; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Nitric Oxide Synthase; Pentolinium Tartrate; Pyrrolidines; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary; Sympathetic Nervous System; Vasoconstriction; Vasodilation | 2015 |
Direct renin inhibitor therapy and swimming training: hemodynamic and cardiac effects in hypertensive and normotensive rats.
Topics: Amides; Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Fumarates; Heart; Hypertension; Male; NG-Nitroarginine Methyl Ester; Physical Conditioning, Animal; Rats; Rats, Wistar; Renin; Risk Factors; Swimming | 2015 |
(-)-Epicatechin prevents alterations in the metabolism of superoxide anion and nitric oxide in the hearts of L-NAME-treated rats.
Topics: Animals; Antihypertensive Agents; Catechin; Coronary Vessels; Dietary Supplements; Disease Models, Animal; Enzyme Activation; Fruit; Heart Ventricles; Hypertension; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Protein Processing, Post-Translational; Random Allocation; Rats, Sprague-Dawley; Stereoisomerism; Superoxides; Vegetables | 2015 |
Hydrogen sulfide defends against the cardiovascular risk of Nw-nitro-L-argininemethyl ester-induced hypertension in rats via the nitric oxide/endothelial nitric oxide synthase pathway.
Topics: Animals; Cardiovascular Diseases; Hydrogen Sulfide; Hypertension; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Signal Transduction | 2014 |
Maternal citrulline supplementation prevents prenatal N(G)-nitro-L-arginine-methyl ester (L-NAME)-induced programmed hypertension in rats.
Topics: Animals; Blood Pressure; Citrulline; Dietary Supplements; Female; Hypertension; Male; Maternal Nutritional Physiological Phenomena; NG-Nitroarginine Methyl Ester; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System | 2015 |
Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Carotid Arteries; Endothelium, Vascular; Hydrazines; Hypertension; Indoles; Losartan; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction; Tetrazoles; Valine; Valsartan; Vasodilation | 2015 |
Heme Oxygenase Improves Renal Function by Potentiating Podocyte-Associated Proteins in Nω-Nitro-l-Arginine-Methyl Ester (l-NAME)-Induced Hypertension.
Topics: Animals; Arginine; Biomarkers; Cytoprotection; Disease Models, Animal; Enzyme Induction; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Heme; Heme Oxygenase (Decyclizing); Hypertension; Inflammation Mediators; Kidney; Male; Mesoporphyrins; NG-Nitroarginine Methyl Ester; Oxidative Stress; Podocytes; Rats, Sprague-Dawley; Signal Transduction | 2015 |
Long-term effects of maternal citrulline supplementation on renal transcriptome prevention of nitric oxide depletion-related programmed hypertension: the impact of gene-nutrient interactions.
Topics: Animals; Blood Pressure; Citrulline; Dietary Supplements; Epigenesis, Genetic; Female; Food; Gene Expression Regulation, Developmental; Gene-Environment Interaction; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Transcriptome | 2014 |
Sinapic acid prevents hypertension and cardiovascular remodeling in pharmacological model of nitric oxide inhibited rats.
Topics: Animals; Anti-Infective Agents; Antioxidants; Blood Pressure; Cardiovascular Diseases; Cells, Cultured; Coumaric Acids; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta; Ventricular Remodeling | 2014 |
PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension.
Topics: Amiloride; Angiotensin II; Animals; Arteries; Blood Pressure; Blood Pressure Determination; Disease Models, Animal; Epithelial Sodium Channels; Female; Hypertension; Kidney; Male; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Proprotein Convertase 9; Proprotein Convertases; Serine Endopeptidases; Sodium; Sodium Chloride, Dietary | 2015 |
Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Hypertension; Inflammation; Interleukin-17; Interleukin-6; Losartan; Male; NADH, NADPH Oxidoreductases; NADPH Oxidase 4; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Up-Regulation | 2015 |
Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.
Topics: Angiotensin II Type 2 Receptor Blockers; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Consciousness; Enzyme Inhibitors; Hypertension; Imidazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Pyridines; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; Species Specificity; Sulfonamides; Sympathetic Nervous System; Sympatholytics; Thiophenes | 2015 |
Transcriptome analysis in rat kidneys: importance of genes involved in programmed hypertension.
Topics: Animals; Blotting, Western; Dexamethasone; Female; Fructose; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transcriptome | 2015 |
Acute administration of single oral dose of grape seed polyphenols restores blood pressure in a rat model of metabolic syndrome: role of nitric oxide and prostacyclin.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Diet; Dose-Response Relationship, Drug; Epoprostenol; Grape Seed Extract; Hypertension; Indomethacin; Male; Metabolic Syndrome; NG-Nitroarginine Methyl Ester; Nitric Oxide; Polyphenols; Rats; Rats, Wistar; Seeds; Vitis | 2016 |
Swimming training prevents alterations in ecto-NTPDase and adenosine deaminase activities in lymphocytes from Nω-nitro-L-arginine methyl ester hydrochloride induced hypertension rats.
Topics: Adenosine Deaminase; Animals; Antigens, CD; Apyrase; Blood Pressure; Hypertension; Lymphocytes; Male; NG-Nitroarginine Methyl Ester; Physical Conditioning, Animal; Random Allocation; Rats; Rats, Wistar; Swimming | 2015 |
Chronic Hypertension Leads to Neurodegeneration in the TgSwDI Mouse Model of Alzheimer's Disease.
Topics: Age of Onset; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Blood-Brain Barrier; Brain; Cerebral Amyloid Angiopathy; Chronic Disease; Dementia, Vascular; Disease Models, Animal; Female; Hippocampus; Humans; Hypertension; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microvessels; Mutation; Nerve Degeneration; NG-Nitroarginine Methyl Ester; Pericytes; Vasculitis | 2015 |
Microglia participate in neurogenic regulation of hypertension.
Topics: Angiotensin II; Animals; Apoptosis; Blood Pressure; Diphtheria Toxin; Disease Models, Animal; Hypertension; Infusions, Intraventricular; Mice; Mice, Inbred C57BL; Microglia; NG-Nitroarginine Methyl Ester; Sympathetic Nervous System | 2015 |
Cardiac-specific overexpression of metallothionein attenuates myocardial remodeling and contractile dysfunction in l-NAME-induced experimental hypertension: Role of autophagy regulation.
Topics: Animals; Autophagy; Calcium; Hypertension; Male; Metallothionein; Mice; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Oxidative Stress; Reactive Oxygen Species; Sirolimus | 2015 |
Effects of one resistance exercise session on vascular smooth muscle of hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Enzyme Inhibitors; Exercise Tolerance; Hypertension; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Phenylephrine; Physical Conditioning, Animal; Potassium Chloride; Rats, Wistar; Time Factors | 2015 |
Glomerulosclerosis in the diet-induced obesity model correlates with sensitivity to nitric oxide inhibition but not glomerular hyperfiltration or hypertrophy.
Topics: Animals; Blood Pressure; Diet, High-Fat; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glomerular Filtration Rate; Glomerulonephritis; Hemodynamics; Hypertension; Hypertrophy; Kidney Glomerulus; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Obesity; Proteinuria; Rats, Sprague-Dawley; Renal Circulation; Time Factors; Vascular Resistance | 2015 |
Effect of magnesium supplementation on blood pressure and vascular reactivity in nitric oxide synthase inhibition-induced hypertension model.
Topics: Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Magnesium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar | 2015 |
Ellagic Acid Prevents L-NAME-Induced Hypertension via Restoration of eNOS and p47phox Expression in Rats.
Topics: Animals; Blood Pressure; Ellagic Acid; Heart Rate; Hypertension; Male; Malondialdehyde; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Sprague-Dawley; Up-Regulation | 2015 |
Salt Sensitivity in Response to Renal Injury Requires Renal Angiotensin-Converting Enzyme.
Topics: Acute Kidney Injury; Angiotensin II; Animals; Disease Models, Animal; Hypertension; Kidney; Mice; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Peptidyl-Dipeptidase A; Sodium Chloride, Dietary | 2015 |
Barnidipine ameliorates the vascular and renal injury in L-NAME-induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cytoprotection; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Inflammation Mediators; Kidney; Kidney Diseases; Male; Malondialdehyde; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase Type III; Oxidative Stress; Peroxidase; Rats, Wistar; Renal Artery; Time Factors; Vascular Remodeling; Vasoconstriction; Vasodilation | 2015 |
Impaired endothelium-dependent vasodilation does not initiate the development of sunitinib-associated hypertension.
Topics: Acetylcholine; Adult; Aged; Angiogenesis Inhibitors; Animals; Carcinoma, Renal Cell; Endothelium, Vascular; Forearm; Humans; Hypertension; Indoles; Kidney Neoplasms; Male; Mesenteric Arteries; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pyrroles; Rats; Regional Blood Flow; Sunitinib; Vascular Endothelial Growth Factor A; Vasodilation; Vasodilator Agents | 2015 |
Mamao Pomace Extract Alleviates Hypertension and Oxidative Stress in Nitric Oxide Deficient Rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Dietary Supplements; Enzyme Inhibitors; Hindlimb; Hypertension; Magnoliopsida; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phytotherapy; Plant Extracts; Polyphenols; Rats, Sprague-Dawley; Regional Blood Flow; Superoxides; Thailand | 2015 |
Asiatic acid alleviates cardiovascular remodelling in rats with L-NAME-induced hypertension.
Topics: Animals; Antihypertensive Agents; Aorta; Biomarkers; Blood Pressure; Collagen; Disease Models, Animal; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Pentacyclic Triterpenes; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha; Vascular Remodeling; Ventricular Remodeling | 2015 |
β2- and β1-Adrenoceptor Expression Exhibits a Common Regulatory Pattern With GRK2 and GRK5 in Human and Animal Models of Cardiovascular Diseases.
Topics: Animals; Case-Control Studies; Disease Models, Animal; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 5; Gene Expression Regulation; Heart Diseases; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Organ Specificity; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; RNA, Messenger | 2015 |
Mas receptor overexpression increased Ang-(1-7) relaxation response in renovascular hypertensive rat carotid.
Topics: Angiotensin I; Animals; Carotid Arteries; Gene Expression Regulation; Hypertension; Ibuprofen; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Vasodilation | 2015 |
Myeloid Suppressor Cells Accumulate and Regulate Blood Pressure in Hypertension.
Topics: Adoptive Transfer; Angiotensin II; Animals; Antigens, Ly; Blood Pressure; CD11b Antigen; Cells, Cultured; Disease Models, Animal; Hydrogen Peroxide; Hypertension; Immune Tolerance; Inflammation Mediators; Lymphocyte Activation; Male; Membrane Glycoproteins; Mice, Inbred C57BL; Mice, Knockout; Myeloid Cells; NADPH Oxidase 2; NADPH Oxidases; Nephritis; NG-Nitroarginine Methyl Ester; Signal Transduction; Sodium, Dietary; T-Lymphocytes; Time Factors | 2015 |
Oral administration of veratric acid, a constituent of vegetables and fruits, prevents cardiovascular remodelling in hypertensive rats: a functional evaluation.
Topics: Administration, Oral; Animals; Antioxidants; Aorta; Ascorbic Acid; Cardiovascular Diseases; Cardiovascular System; Catalase; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Glutathione; Glutathione Peroxidase; Hypertension; Lipid Peroxidation; Lipid Peroxides; Male; NG-Nitroarginine Methyl Ester; Oxidative Stress; Rats; Rats, Wistar; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Vanillic Acid; Vascular Remodeling; Vegetables; Vitamin E | 2015 |
Endothelial Mineralocorticoid Receptors Differentially Contribute to Coronary and Mesenteric Vascular Function Without Modulating Blood Pressure.
Topics: Acetylcholine; Animals; Blood Pressure; Coronary Vessels; Disease Models, Animal; Endothelium, Vascular; Hypertension; Male; Mesentery; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Receptors, Mineralocorticoid; Regional Blood Flow; Risk Factors; Vascular Resistance | 2015 |
Persistent change in cardiac fibroblast physiology after transient ACE inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cardiomyopathies; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Collagen Type I; Disease Models, Animal; Enalapril; Fibroblasts; Fibrosis; Granulocyte-Macrophage Colony-Stimulating Factor; Heart Ventricles; Hypertension; Inflammation Mediators; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenotype; Rats, Inbred SHR; Time Factors | 2015 |
Effect of magnesium on vascular reactivity in NOS inhibition-induced hypertension.
Topics: Animals; Endothelium, Vascular; Hypertension; Magnesium; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Culture Techniques; Rats; Rats, Wistar | 2015 |
Mechanisms of the antihypertensive effects of Nigella sativa oil in L-NAME-induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heme Oxygenase (Decyclizing); Hypertension; Male; Malondialdehyde; Models, Animal; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nicardipine; Nigella sativa; Nitric Oxide; Oxidative Stress; Peptidyl-Dipeptidase A; Plant Oils; Rats, Sprague-Dawley | 2015 |
Vasodilatory Effect of Wogonin on the Rat Aorta and Its Mechanism Study.
Topics: Animals; Aorta; Calcium; Drugs, Chinese Herbal; Endothelium, Vascular; Eucommiaceae; Flavanones; Hypertension; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Norepinephrine; Phytotherapy; Potassium Chloride; Rats, Wistar; Vasoconstriction; Vasodilator Agents | 2015 |
Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Angiotensin II; Animals; Blood Pressure; Brain; Cerebral Amyloid Angiopathy; Female; Humans; Hypertension; Intracranial Hemorrhage, Hypertensive; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Risk Factors; Stroke | 2016 |
The Effect of Magnesium on Visual Evoked Potentials in L-NAME-Induced Hypertensive Rats.
Topics: Animals; Disease Models, Animal; Evoked Potentials, Visual; Hypertension; Magnesium; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances | 2016 |
Potent antihypertensive effect of Hancornia speciosa leaves extract.
Topics: Animals; Antihypertensive Agents; Apocynaceae; Blood Pressure; Brazil; Desoxycorticosterone; Hydrogen Peroxide; Hypertension; Male; Mesenteric Arteries; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Plant Extracts; Plant Leaves; Vasodilation; Vasodilator Agents | 2016 |
Synergistic Antihypertensive Effect of Carthamus tinctorius L. Extract and Captopril in L-NAME-Induced Hypertensive Rats via Restoration of eNOS and AT₁R Expression.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Carthamus tinctorius; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Phytotherapy; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Time Factors; Vasodilation | 2016 |
Prevention of cardiac dysfunction, kidney fibrosis and lipid metabolic alterations in l-NAME hypertensive rats by sinapic acid--Role of HMG-CoA reductase.
Topics: Acyl Coenzyme A; Animals; Antioxidants; Blood Pressure; Coumaric Acids; Fibrosis; Heart; Hypertension; Kidney; Lipid Peroxidation; Lipoproteins; Male; Mitochondria, Liver; Molecular Docking Simulation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Oxidative Stress; Protein Conformation; Rats; Rats, Wistar | 2016 |
CD70 Exacerbates Blood Pressure Elevation and Renal Damage in Response to Repeated Hypertensive Stimuli.
Topics: Animals; Blood Pressure; CD27 Ligand; Hypertension; Inflammation Mediators; Kidney Diseases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Sodium Chloride, Dietary; T-Lymphocytes | 2016 |
Nitric Oxide Deficit Drives Intimal Hyperplasia in Mouse Models of Hypertension.
Topics: Animals; Carotid Arteries; Disease Models, Animal; Hyperplasia; Hypertension; Male; Mice; Mice, Inbred C57BL; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide | 2016 |
Evidences of antihypertensive potential of extract from Solanum capsicoides All. in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Mesenteric Arteries; Molecular Structure; NG-Nitroarginine Methyl Ester; Phenols; Plant Components, Aerial; Plant Extracts; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Solanum | 2016 |
Effects of a novel ACE inhibitor, 3-(3-thienyl)-l-alanyl-ornithyl-proline, on endothelial vasodilation and hepatotoxicity in l-NAME-induced hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biomarkers; Captopril; Endothelium, Vascular; Hypertension; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Rats; Rats, Wistar; Vasodilation | 2016 |
Dietary Supplementation of Ginger and Turmeric Rhizomes Modulates Platelets Ectonucleotidase and Adenosine Deaminase Activities in Normotensive and Hypertensive Rats.
Topics: Adenosine Deaminase; Adenosine Triphosphatases; Animals; Blood Platelets; Blood Pressure; Curcuma; Dietary Supplements; Hypertension; Male; NG-Nitroarginine Methyl Ester; Phytotherapy; Rats; Rats, Wistar; Rhizome; Zingiber officinale | 2016 |
Improvement of Acetylcholine-Induced Vasodilation by Acute Exercise in Ovariectomized Hypertensive Rats.
Topics: Acetylcholine; Animals; Antioxidants; Blood Pressure; Enzyme Inhibitors; Female; Heart Rate; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Ovariectomy; Oxidative Stress; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sedentary Behavior; Vasodilation; Vasodilator Agents | 2016 |
Effects of magnesium supplementation on electrophysiological remodeling of cardiac myocytes in L-NAME induced hypertensive rats.
Topics: Animals; Atrial Remodeling; Calcium; Cardiomegaly; Dietary Supplements; Heart Ventricles; Hypertension; Magnesium; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Oxidative Stress; Rats | 2016 |
Centrally administered TNF increases arterial blood pressure independently of nitric oxide synthase.
Topics: Administration, Intravenous; Animals; Arterial Pressure; Baroreflex; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2016 |
Maternal melatonin or N-acetylcysteine therapy regulates hydrogen sulfide-generating pathway and renal transcriptome to prevent prenatal N
Topics: Acetylcysteine; Administration, Oral; Animals; Antioxidants; Biomarkers; Female; Fetal Development; Hydrogen Sulfide; Hypertension; Kidney; Male; Melatonin; NG-Nitroarginine Methyl Ester; Oxidative Stress; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Sprague-Dawley; Transcriptome | 2016 |
Effect of nitric oxide deficiency on the pulmonary PTHrP system.
Topics: Animals; Hypertension; Lung; Lung Diseases; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Parathyroid Hormone-Related Protein; Rats; Renin-Angiotensin System | 2017 |
Effect of nebivolol treatment during pregnancy on the intrauterine fetal growth, mortality and pup postnatal development in the l-NAME-induced hypertensive rats.
Topics: Animals; Animals, Newborn; Blood Pressure; Body Weight; Capillaries; Female; Fetal Development; Heart Rate; Hypertension; Nebivolol; NG-Nitroarginine Methyl Ester; Pregnancy; Pregnancy Complications; Rats; Rats, Wistar; Uterus | 2016 |
Evaluation of anti-hypertensive activity of Ulmus wallichiana extract and fraction in SHR, DOCA-salt- and L-NAME-induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone Acetate; Hypertension; India; Male; Medicine, Traditional; NG-Nitroarginine Methyl Ester; Plant Bark; Plant Extracts; Plant Stems; Rats, Inbred SHR; Rats, Sprague-Dawley; Rats, Wistar; Toxicity Tests, Acute; Ulmus | 2016 |
Irisin Lowers Blood Pressure by Improvement of Endothelial Dysfunction via AMPK-Akt-eNOS-NO Pathway in the Spontaneously Hypertensive Rat.
Topics: AMP-Activated Protein Kinases; Animals; Antihypertensive Agents; Blood Pressure; Cells, Cultured; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Fibronectins; Humans; Hypertension; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Phosphorylation; Rats, Inbred SHR; Rats, Inbred WKY; Up-Regulation; Vasodilation; Vasodilator Agents | 2016 |
Renal tubular angiotensin converting enzyme is responsible for nitro-L-arginine methyl ester (L-NAME)-induced salt sensitivity.
Topics: Angiotensin II; Animals; Arterial Pressure; Disease Models, Animal; Epithelial Sodium Channels; Gene Expression Regulation, Enzymologic; Hypertension; Kidney Tubules; Liver; Mice, Transgenic; Natriuresis; NG-Nitroarginine Methyl Ester; Peptidyl-Dipeptidase A; Renal Elimination; Renin-Angiotensin System; Sodium Chloride, Dietary; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 3; Time Factors | 2017 |
The antioxidant effects of green tea reduces blood pressure and sympathoexcitation in an experimental model of hypertension.
Topics: Animals; Antioxidants; Baroreflex; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Heart Rate; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Sympathetic Nervous System; Tea | 2017 |
Shear stress-mediated upregulation of GTP cyclohydrolase/tetrahydrobiopterin pathway ameliorates hypertension-related decline in reendothelialization capacity of endothelial progenitor cells.
Topics: Animals; Biopterins; Cells, Cultured; Cyclic GMP; Down-Regulation; Endothelial Progenitor Cells; Gene Knockdown Techniques; GTP Cyclohydrolase; Human Umbilical Vein Endothelial Cells; Humans; Hypertension; Male; Metabolic Networks and Pathways; Mice; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Stress, Mechanical; Thrombospondin 1; Up-Regulation | 2017 |
The effects of pollen, propolis, and caffeic acid phenethyl ester on tyrosine hydroxylase activity and total RNA levels in hypertensive rats caused by nitric oxide synthase inhibition: experimental, docking and molecular dynamic studies.
Topics: Adrenal Medulla; Animals; Caffeic Acids; Catalytic Domain; Catecholamines; Disease Models, Animal; Heart; Humans; Hypertension; Hypothalamus; Models, Molecular; Molecular Docking Simulation; Molecular Dynamics Simulation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenylethyl Alcohol; Pollen; Propolis; Rats; Tyrosine 3-Monooxygenase | 2018 |
Changes in the expression of α
Topics: Adult; Aldosterone; Animals; Blood Pressure; Enzyme Inhibitors; Female; Homocysteine; Humans; Hypertension; Kidney; Male; Middle Aged; Monocytes; Myocardium; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-1; RNA, Messenger | 2017 |
Effect of ivabradine, captopril and melatonin on the behaviour of rats in L-nitro-arginine methyl ester-induced hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Behavior, Animal; Benzazepines; Blood Pressure; Captopril; Heart Rate; Hypertension; Ivabradine; Locomotion; Male; Melatonin; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2016 |
Gallic acid attenuates hypertension, cardiac remodeling, and fibrosis in mice with NG-nitro-L-arginine methyl ester-induced hypertension via regulation of histone deacetylase 1 or histone deacetylase 2.
Topics: Animals; Blood Pressure; Fibrosis; Gallic Acid; Heart Ventricles; Histone Deacetylase 1; Histone Deacetylase 2; Hypertension; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Ventricular Remodeling | 2017 |
Carbon monoxide does not contribute to vascular tonus improvement in exercise-trained rats with chronic nitric oxide synthase inhibition.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Carbon Monoxide; Citrate (si)-Synthase; Heme Oxygenase (Decyclizing); Hypertension; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle Tonus; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Physical Conditioning, Animal; Rats, Wistar; Vascular Resistance | 2017 |
Endothelium-independent vasorelaxant activity of Trachyspermum ammi essential oil on rat aorta.
Topics: Animals; Aorta; Aorta, Thoracic; Apiaceae; Calcium; Calcium Channel Blockers; Cyclohexane Monoterpenes; Cymenes; Enzyme Inhibitors; Hypertension; Monoterpenes; NG-Nitroarginine Methyl Ester; Nifedipine; Oils, Volatile; Phenylephrine; Plant Oils; Rats; Rats, Wistar; Thymol; Vasodilation | 2017 |
Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype.
Topics: Aging; Angiotensin II; Animals; Cerebral Hemorrhage; Disease Models, Animal; Extracellular Matrix; Gait; Hypertension; Infusion Pumps, Implantable; Insulin-Like Growth Factor I; Male; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Oxidative Stress; Phenotype; Psychomotor Performance | 2017 |
Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzazepines; Bosentan; Endothelin-Converting Enzymes; Endothelium, Vascular; Enzyme Inhibitors; Hydralazine; Hypertension; Losartan; Mesenteric Arteries; Muscle Contraction; Neprilysin; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Protease Inhibitors; Rats; Rats, Inbred SHR; Sulfonamides; Vascular Resistance | 2017 |
Sildenafil augments the beneficial hemodynamic and histopathological effects of amlodipine in nitric oxide-deficient hypertensive rats: role of nitric oxide-cyclic GMP pathway.
Topics: Amlodipine; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cyclic GMP; Enzyme Inhibitors; Heart Rate; Hypertension; Kidney; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Signal Transduction; Sildenafil Citrate; Sulfones | 2008 |
The effect of ovariectomy on cardiac autonomic control in rats submitted to aerobic physical training.
Topics: Administration, Oral; Adrenergic beta-Antagonists; Analysis of Variance; Animals; Atropine Derivatives; Autonomic Nervous System; Baroreflex; Blood Pressure; Cardiovascular System; Female; Heart Rate; Hypertension; Injections, Intravenous; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovariectomy; Parasympatholytics; Physical Conditioning, Animal; Propranolol; Rats; Rats, Wistar | 2008 |
Effect of NO synthase inhibition on cardiovascular circadian rhythms in wild-type and eNOS-knock-out mice.
Topics: Animals; Blood Pressure; Cardiovascular System; Circadian Rhythm; Enzyme Inhibitors; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Radio Waves; Telemetry; Time Factors | 2008 |
Regression of L-NAME-induced hypertension: the role of nitric oxide and endothelium-derived constricting factor.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Femoral Artery; Hypertension; Hypertrophy, Left Ventricular; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; RNA, Messenger; Signal Transduction | 2008 |
Acute impairment of rat renal function by L -NAME as measured using dynamic MRI.
Topics: Animals; Blood Pressure; Female; Glomerular Filtration Rate; Hypertension; Kidney; Magnetic Resonance Imaging; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 2008 |
The muscle-collagen ratio in left ventricular hypertrophy and aorta remodelling in hypertension.
Topics: Animals; Aorta; Collagen; Hypertension; Hypertrophy, Left Ventricular; Models, Animal; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats | 2008 |
Allopurinol attenuates L-NAME induced cardiomyopathy comparable to blockade of angiotensin receptor.
Topics: Allopurinol; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Cardiomyopathies; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Imidazoles; Male; Myocardium; NG-Nitroarginine Methyl Ester; Olmesartan Medoxomil; Rats; Rats, Wistar; Tetrazoles; Time Factors; Uric Acid; Ventricular Remodeling; Xanthine Oxidase | 2008 |
Dietary doses of nitrite restore circulating nitric oxide level and improve renal injury in L-NAME-induced hypertensive rats.
Topics: Administration, Oral; Animals; Blood Pressure; Body Weight; Diet; Glycated Hemoglobin; Hypertension; Kidney; Kidney Diseases; Kidney Glomerulus; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Proteinuria; Rats; Rats, Sprague-Dawley | 2008 |
The role of inflammatory markers in the cardioprotective effect of L-carnitine in L-NAME-induced hypertension.
Topics: Animals; Biomarkers; Blood Pressure; Body Weight; Cardiotonic Agents; Carnitine; Disease Models, Animal; Hypertension; Interleukin-1beta; Interleukin-6; Male; Myocardium; NG-Nitroarginine Methyl Ester; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; RNA, Messenger; Tumor Necrosis Factor-alpha | 2008 |
Melatonin protects myocardium from ischemia-reperfusion injury in hypertensive rats: role of myeloperoxidase activity.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Glutathione; Hypertension; Lipid Peroxidation; Male; Malondialdehyde; Melatonin; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Wistar | 2008 |
Endothelin and gelatinases in renal changes following blockade of nitric oxide synthase in hypertensive rats.
Topics: Animals; Azepines; Blood Urea Nitrogen; Collagen; Creatinine; Cyclic GMP; Disease Models, Animal; Endothelin-1; Enzyme Inhibitors; Gelatinases; Glomerular Filtration Rate; Hypertension; Indoles; Kidney; Matrix Metalloproteinases; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Tissue Inhibitor of Metalloproteinase-2 | 2008 |
Renoprotective effects of soy protein hydrolysates in N(omega)-nitro-L-arginine methyl ester hydrochloride-induced hypertensive rats.
Topics: Animals; Cytochrome P-450 CYP4A; Hydroxyeicosatetraenoic Acids; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Soybean Proteins | 2008 |
Protein restriction during pregnancy induces hypertension and impairs endothelium-dependent vascular function in adult female offspring.
Topics: Animals; Birth Weight; Blood Pressure; Dietary Proteins; Endothelium, Vascular; Estrus; Female; Fetal Growth Retardation; Hypertension; Male; Maternal Nutritional Physiological Phenomena; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pregnancy; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 2009 |
Ouabain treatment changes the role of endothelial factors in rat resistance arteries.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiotonic Agents; Cyclooxygenase 2; Dose-Response Relationship, Drug; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Heart Rate; Hypertension; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Ouabain; Phenylephrine; Rats; Rats, Wistar | 2008 |
Role of NOX2 in the regulation of afferent arteriole responsiveness.
Topics: Acetophenones; Adenosine; Angiotensin II; Animals; Arterioles; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Infusion Pumps, Implantable; Infusions, Subcutaneous; Kidney Cortex; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Knockout; NADPH Oxidase 2; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Renal Circulation; Superoxides; Vasoconstriction; Vasoconstrictor Agents | 2009 |
Chronic low-dose L-NAME treatment effect on cardiovascular system of borderline hypertensive rats: feedback regulation?
Topics: Acetylcholine; Animals; Blood Pressure; Body Weight; Cardiovascular Physiological Phenomena; Enzyme Inhibitors; Feedback, Physiological; Hypertension; Isometric Contraction; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Organ Size; Rats; Rats, Inbred WKY; Rats, Wistar | 2008 |
Valsartan improves L-NAME-exacerbated cardiac fibrosis with TGF-ß inhibition and apoptosis induction in spontaneously hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; Caspase 3; Fibrosis; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; RNA; Tetrazoles; Transforming Growth Factor beta; Valine; Valsartan; Ventricular Remodeling | 2008 |
Experimental induction of salt-sensitive hypertension is associated with lymphocyte proliferative response to HSP70.
Topics: Angiotensin II; Animals; Autoimmunity; Cell Proliferation; Cells, Cultured; Disease Models, Animal; HSP70 Heat-Shock Proteins; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Proteinuria; Rats; Rats, Sprague-Dawley; Salt Tolerance; T-Lymphocytes | 2008 |
Solanum indicum ssp. distichum extract is effective against L-NAME-induced hypertension in rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Fruit; Hypertension; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Solanum; Time Factors | 2008 |
L-Serine lowers while glycine increases blood pressure in chronic L-NAME-treated and spontaneously hypertensive rats.
Topics: Animals; Apamin; Blood Pressure; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glycine; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Potassium Channels, Calcium-Activated; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Serine; Threonine | 2008 |
Effects of hypertension on vasorelaxation to endocannabinoids in vitro.
Topics: Animals; Aorta; Arachidonic Acids; Cannabinoid Receptor Modulators; Capsaicin; Carbachol; Endocannabinoids; Endothelium; Hypertension; Male; Mesenteric Arteries; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Polyunsaturated Alkamides; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; TRPV Cation Channels; Vasodilation | 2009 |
Effect of Citrus paradisi extract and juice on arterial pressure both in vitro and in vivo.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Citrus paradisi; Dogs; Female; Heart; Humans; Hypertension; Lung; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Vascular Resistance | 2009 |
Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo.
Topics: Acetylcholine; Animals; Blood Pressure; Calcium Signaling; Carotid Arteries; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Mesenteric Arteries; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; RNA, Messenger; TRPV Cation Channels; Vasodilation; Vasodilator Agents | 2009 |
Abundance of the Na-K-2Cl cotransporter NKCC2 is increased by high-fat feeding in Fischer 344 X Brown Norway (F1) rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Pressure; Blotting, Western; Crosses, Genetic; Cyclic N-Oxides; Dietary Fats; Dinoprost; Enzyme Inhibitors; Furosemide; Glucose Intolerance; Hypertension; Insulin Resistance; Kidney Medulla; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Potassium Channels, Inwardly Rectifying; Rats; Rats, Inbred BN; Rats, Inbred F344; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Solute Carrier Family 12, Member 1; Spin Labels; Telemetry; Time Factors; Up-Regulation | 2009 |
Physical exercise attenuates the cardiac autonomic deficit induced by nitric oxide synthesis blockade.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Atropine Derivatives; Autonomic Nervous System; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Physical Conditioning, Animal; Propranolol; Rats; Rats, Wistar | 2009 |
Effect of L-NAME-induced hypertension on melatonin receptors and melatonin levels in the pineal gland and the peripheral organs of rats.
Topics: Animals; Aorta; Blotting, Western; Circadian Rhythm; Enzyme Inhibitors; Hypertension; Kidney; Light; Male; Melatonin; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pineal Gland; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2009 |
Cardiac and Kidney Weight Indices following Dietary Salt Loading and/or Chronic Nitric Oxide Synthase Inhibition in the Hooded (Aguti) Rat.
Topics: Animals; Arginine; Blood Pressure; Body Weight; Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nigeria; Nitric Oxide Synthase; Rats | 2009 |
Effect of chronic inhibition of nitric oxide on hypertension, insulin resistance, and cardiovascular remodeling in glucose-fed rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Diet; Epinephrine; Glucose; Hypertension; Hypertrophy; Insulin Resistance; Male; Muscle, Smooth, Vascular; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxides; Ventricular Remodeling | 2009 |
L-carnitine, inflammation and hypertension.
Topics: Carnitine; Heme Oxygenase-1; Humans; Hypertension; Inflammation; NG-Nitroarginine Methyl Ester | 2009 |
Improvement of renal hemodynamics during hypertension-induced chronic renal disease: role of EGF receptor antagonism.
Topics: Animals; Arterioles; Blood Pressure; Chronic Disease; Disease Models, Animal; Enzyme Inhibitors; ErbB Receptors; Gefitinib; Hypertension; Kidney; Kidney Diseases; Male; NG-Nitroarginine Methyl Ester; Quinazolines; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Vasoconstriction | 2009 |
Hypertensive effects of oral administration of the aqueous extract of Solanum torvum fruits in L-NAME treated rats: evidence from in vivo and in vitro studies.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Carbachol; Enzyme Inhibitors; Female; Fruit; Heart Rate; Hypertension; In Vitro Techniques; Indicators and Reagents; Kidney; Male; Mice; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Organ Size; Parasympathomimetics; Plant Extracts; Rats; Solanum; Vasoconstrictor Agents | 2009 |
Nitric oxide synthesis blockade reduced the baroreflex sensitivity in trained rats.
Topics: Adaptation, Physiological; Animals; Atropine Derivatives; Autonomic Nervous System; Baroreflex; Blood Pressure; Drug Administration Schedule; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Parasympatholytics; Propranolol; Rats; Rats, Wistar; Spectrum Analysis; Vasodilator Agents | 2009 |
No evidence for an enhanced role of endothelial nitric oxide in the maintenance of arterial blood pressure in the IUGR sheep fetus.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Female; Fetal Growth Retardation; Fetus; Gestational Age; Humans; Hypertension; Hypoxia; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pregnancy; Prenatal Exposure Delayed Effects; Sheep; Vasodilation | 2009 |
Hypertension alters the function of nitrergic and sensory innervation in mesenteric arteries from female rats.
Topics: Animals; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Electric Stimulation; Female; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor Activity-Modifying Proteins; Sex Characteristics; Vasoconstriction | 2009 |
Additive effect of cyclooxygenase and nitric oxide synthase blockade on the cerebrocortical microcirculation.
Topics: Animals; Blood Pressure; Cerebral Cortex; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Epoprostenol; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandin-Endoperoxide Synthases; Random Allocation; Rats; Rats, Wistar | 2009 |
Counter-regulation by atorvastatin of gene modulations induced by L-NAME hypertension is associated with vascular protection.
Topics: Animals; Aorta; Atorvastatin; Endothelium, Vascular; Gene Expression Regulation; Heptanoic Acids; Hypertension; Male; NG-Nitroarginine Methyl Ester; Pyrroles; Rats; Rats, Inbred F344 | 2009 |
Impairment of endothelium-dependent vasorelaxation in cadmium-hypertensive rats.
Topics: Acetylcholine; Animals; Arginine; Cadmium; Endothelium, Vascular; Hypertension; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Vasodilation | 2009 |
The dual effects of leptin on aortic rings with and without endothelium isolated from streptozotocin-induced diabetic rats.
Topics: Animals; Aorta; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; In Vitro Techniques; Leptin; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Streptozocin; Vasoconstriction | 2009 |
Vascular endothelial growth factor inhibitors and hypertension: a central role for the kidney and endothelial factors?
Topics: Animals; Antibodies, Monoclonal; Blood Pressure; Enzyme Inhibitors; Gene Expression; Hypertension; Kidney; Mice; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
Vascular endothelial growth factor receptor 2 controls blood pressure by regulating nitric oxide synthase expression.
Topics: Aldosterone; Animals; Antibodies, Monoclonal; Blood Pressure; Enzyme Inhibitors; Gene Expression; Hybridomas; Hypertension; Kidney; Male; Manometry; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Prostaglandins; Renin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Sodium Chloride, Dietary; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factor Receptor-2 | 2009 |
PPAR-gamma agonist rosiglitazone reverses increased cerebral venous hydraulic conductivity during hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Brain Edema; Capillary Permeability; Cerebral Veins; Cerebrovascular Circulation; Chronic Disease; Cyclic N-Oxides; Disease Models, Animal; Female; Hydrostatic Pressure; Hypertension; NG-Nitroarginine Methyl Ester; PPAR gamma; Rats; Rats, Sprague-Dawley; Rosiglitazone; Spin Labels; Thiazolidinediones; Time Factors | 2009 |
The role of nitric oxide in the development of neurogenic pulmonary edema in spinal cord-injured rats: the effect of preventive interventions.
Topics: Anesthetics, Inhalation; Animals; Atropine; Baroreflex; Blood Pressure; Bradycardia; Disease Models, Animal; Drug Administration Schedule; Enzyme Inhibitors; Ganglionic Blockers; Heart Rate; Hypertension; Isoflurane; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentolinium Tartrate; Pulmonary Edema; Rats; Rats, Wistar; Spinal Cord Injuries; Sympathetic Nervous System; Time Factors; Vasoconstriction | 2009 |
Characterization of the contractile 5-hydroxytryptamine receptor in the autoperfused kidney of L-NAME hypertensive rats.
Topics: Anesthesia; Animals; Blood Pressure; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Perfusion; Rats; Rats, Wistar; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Vasoconstriction | 2009 |
Biomechanical strain causes maladaptive gene regulation, contributing to Alport glomerular disease.
Topics: Adaptation, Physiological; Animals; Blood Pressure; Cells, Cultured; Cytoskeleton; Disease Models, Animal; Gene Expression Regulation; Glomerular Basement Membrane; Hypertension; Interleukin-6; Kidney Glomerulus; Matrix Metalloproteinase 10; Matrix Metalloproteinase 14; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Matrix Metalloproteinases; Mice; Mice, Inbred C57BL; Nephritis, Hereditary; NG-Nitroarginine Methyl Ester; Podocytes; Proteinuria; RNA, Messenger; Sodium Chloride, Dietary; Stress, Mechanical; Time Factors | 2009 |
Antihypertensive and endothelium-dependent vasodilator effects of aqueous extract of Cistus ladaniferus.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cistus; Endothelium, Vascular; Heart; Hypertension; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Vasodilator Agents; Water | 2009 |
Inhibition of nitric oxide synthase evokes central sympatho-excitation in healthy humans.
Topics: Adult; Blood Pressure; Central Nervous System; Enzyme Inhibitors; Female; Humans; Hypertension; Infusions, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Skin; Sympathetic Nervous System | 2009 |
Protective actions of estrogen on angiotensin II-induced hypertension: role of central nitric oxide.
Topics: Angiotensin II; Animals; Blood Pressure; Blotting, Western; Disease Models, Animal; Enzyme Inhibitors; Estrogens; Female; Ganglionic Blockers; Hexamethonium; Hypertension; Immunohistochemistry; Infusion Pumps, Implantable; Infusions, Subcutaneous; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Orchiectomy; Ornithine; Ovariectomy; Paraventricular Hypothalamic Nucleus; Receptors, Estrogen; Sex Factors; Subfornical Organ; Sympathetic Nervous System; Telemetry; Time Factors; Up-Regulation | 2009 |
Angiotensin II enhances GABA(B) receptor-mediated responses and expression in nucleus tractus solitarii of rats.
Topics: Angiotensin II; Animals; Baclofen; Baroreflex; Bicuculline; Blood Pressure; Disease Models, Animal; GABA Agonists; GABA Antagonists; Hypertension; Infusion Pumps, Implantable; Male; Microinjections; Muscimol; NG-Nitroarginine Methyl Ester; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, GABA-B; Solitary Nucleus; Time Factors; Up-Regulation | 2009 |
Regular exercise produced cardioprotective effects on rat's heart with hypertension induced by L-NAME administration.
Topics: Angiotensin II; Animals; Apoptosis; Blood Pressure; Body Weight; Disease Models, Animal; Heart; Hypertension; Hypertrophy, Left Ventricular; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Physical Conditioning, Animal; Rats | 2009 |
Clopidogrel, independent of the vascular P2Y12 receptor, improves arterial function in small mesenteric arteries from AngII-hypertensive rats.
Topics: Acetylcholine; Adenosine Diphosphate; Angiotensin II; Animals; Blotting, Western; Clopidogrel; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Purinergic P2Y Receptor Antagonists; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2Y12; Thionucleotides; Ticlopidine; Vasodilation; Vasodilator Agents | 2010 |
Endothelial nitric oxide synthase uncoupling and perivascular adipose oxidative stress and inflammation contribute to vascular dysfunction in a rodent model of metabolic syndrome.
Topics: Adipose Tissue; Animals; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Metabolic Syndrome; Mice; Mice, Inbred Strains; Mice, Obese; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Vascular Resistance; Vasculitis | 2009 |
Evidence that nitric oxide inhibits vascular inflammation and superoxide production via a p47phox-dependent mechanism in mice.
Topics: Angiotensin II; Animals; Aorta; Atherosclerosis; Blood Pressure; Enzyme Inhibitors; Glycosylation; Hypertension; Male; Membrane Glycoproteins; Mice; Mice, Inbred C57BL; Mice, Transgenic; NADPH Oxidase 2; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Reactive Oxygen Species; Superoxides; Time Factors; Vascular Cell Adhesion Molecule-1; Vasculitis | 2010 |
Blood pressure and renal blow flow responses in heme oxygenase-2 knockout mice.
Topics: Administration, Oral; Angiotensin II; Animals; Blood Pressure; Cardiomegaly; Disease Models, Animal; Female; Heme Oxygenase (Decyclizing); Hypertension; Infusion Pumps, Implantable; Infusions, Subcutaneous; Kidney; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Renal Circulation; Vascular Resistance; Vasoconstriction | 2009 |
Sympathetic activity is not increased in L-NAME hypertensive rats.
Topics: Animals; Baroreflex; Blood Pressure; Consciousness; Disease Models, Animal; Enzyme Inhibitors; Heart Rate; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Norepinephrine; Rats; Rats, Wistar; Sympathetic Nervous System; Time Factors | 2010 |
Influence of hypercholesterolemia and hypertension on the integrity of the blood-brain barrier in rats.
Topics: Analysis of Variance; Angiotensin II; Animals; Blood-Brain Barrier; Body Weight; Catalase; Cholesterol; Disease Models, Animal; Glial Fibrillary Acidic Protein; Glutathione; Hypercholesterolemia; Hypertension; Lipoproteins, LDL; Male; Malondialdehyde; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphoproteins; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Vascular Endothelial Growth Factor A; Zonula Occludens-1 Protein | 2009 |
Inhibitory effects of angiotensin-(1-7) on the nerve stimulation-induced release of norepinephrine and neuropeptide Y from the mesenteric arterial bed.
Topics: Angiotensin I; Animals; Antihypertensive Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Electric Stimulation; Hypertension; Imidazoles; Male; Mesenteric Arteries; Neuropeptide Y; NG-Nitroarginine Methyl Ester; Norepinephrine; Peptide Fragments; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 2; Sympathetic Nervous System; Synaptic Transmission | 2010 |
Influence of pertussis toxin pretreatment on the development of L-NAME-induced hypertension.
Topics: Animals; Disease Models, Animal; GTP-Binding Protein alpha Subunits, Gi-Go; Hypertension; Male; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Rats; Rats, Wistar | 2009 |
Chronic inhibition of nitric-oxide synthase induces hypertension and erectile dysfunction in the rat that is not reversed by sildenafil.
Topics: Animals; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Erectile Dysfunction; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Penile Erection; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Sprague-Dawley; Sildenafil Citrate; Sulfones; Up-Regulation | 2010 |
Alterations in the modulation of cerebrovascular tone and blood flow by nitric oxide synthases in SHRsp with stroke.
Topics: Animals; Arginine; Biopterins; Blood Pressure; Cerebral Hemorrhage; Cerebrovascular Circulation; Enzyme Inhibitors; Homeostasis; Hypertension; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Stroke; Vasodilation | 2010 |
Refractory blood pressure in female SHR to increased oxidative stress is not mediated by NO or by upregulation of renal antioxidant enzymes.
Topics: Animals; Antioxidants; Blood Pressure; Female; Hypertension; Isoprostanes; Kidney; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Up-Regulation; Vasodilator Agents | 2010 |
Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Hyperplasia; Hypertension; Inhibitor of Differentiation Proteins; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Norepinephrine; Organ Specificity; Receptor, Angiotensin, Type 1; Renin; Tunica Media | 2010 |
Dual effect of polyphenolic compounds on cardiac Na+/K+-ATPase during development and persistence of hypertension in rats.
Topics: Animals; Blood Pressure; Enzyme Activation; Flavonoids; Heart; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenols; Polyphenols; Rats; Rats, Inbred WKY; Sodium-Potassium-Exchanging ATPase | 2009 |
Melatonin interactions with blood pressure and vascular function during L-NAME-induced hypertension.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase 2; Endothelins; Hypertension; Male; Melatonin; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Vasodilation | 2010 |
Leptin reduces plasma ANP level via nitric oxide-dependent mechanism.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Carotid Arteries; Hypertension; Isoproterenol; Jugular Veins; Kidney; Leptin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reserpine; RNA, Messenger | 2010 |
Aerobic exercise acutely improves insulin- and insulin-like growth factor-1-mediated vasorelaxation in hypertensive rats.
Topics: Androstadienes; Animals; Endothelium, Vascular; Hypertension; Insulin; Insulin-Like Growth Factor I; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxide Dismutase; Vasodilation; Wortmannin | 2010 |
Strain-dependent susceptibility for hypertension in mice resides in the natural killer gene complex.
Topics: Animals; Antigens, Ly; Blood Pressure; CD11b Antigen; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Genetic Predisposition to Disease; Hypertension; Male; Mice; Mice, Congenic; Mice, Inbred BALB C; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; NK Cell Lectin-Like Receptor Subfamily B | 2010 |
Purinergic contraction of the rat vas deferens in L-NAME-induced hypertension: effect of sildenafil.
Topics: Adenosine Triphosphate; Animals; Electric Stimulation; Enzyme Inhibitors; Hypertension; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Phenylephrine; Piperazines; Purinergic P2 Receptor Agonists; Purinergic P2 Receptor Antagonists; Purines; Pyridoxal Phosphate; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X; Receptors, Purinergic P2X3; Sildenafil Citrate; Sulfones; Vas Deferens; Vasodilator Agents | 2010 |
Genetic locus on MWF rat chromosome 6 affects kidney damage in response to L-NAME treatment in spontaneously hypertensive rats.
Topics: Albuminuria; Animals; Blood Pressure; Chromosomes, Mammalian; Crosses, Genetic; Enzyme Inhibitors; Female; Hypertension; Kidney; Kidney Glomerulus; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Quantitative Trait Loci; Rats; Rats, Inbred SHR; Rats, Wistar; Time Factors | 2010 |
PPAR{gamma} activation prevents hypertensive remodeling of cerebral arteries and improves vascular function in female rats.
Topics: Animals; Blood Pressure; Brain; Capillaries; Cerebral Arteries; Enzyme Inhibitors; Female; Hypertension; Hypoglycemic Agents; NG-Nitroarginine Methyl Ester; PPAR gamma; Rats; Rats, Sprague-Dawley; Rosiglitazone; Thiazolidinediones | 2010 |
Correction of endothelial dysfunction with impaza preparation in complex with enalapril and losartan during modeling of NO deficiency.
Topics: Animals; Antibodies; Enalapril; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar | 2009 |
Comparative study of potential endothelioprotectors and impaza in modeled nitric oxide deficiency.
Topics: Animals; Antibodies; Antihypertensive Agents; Antioxidants; Endothelium, Vascular; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitrites; Rats; Rats, Wistar; Resveratrol; Stilbenes | 2009 |
Effects of pregnancy, hypertension and nitric oxide inhibition on rat uterine artery myogenic reactivity.
Topics: Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Female; Hydralazine; Hypertension; Hypertension, Pregnancy-Induced; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Rats; Rats, Sprague-Dawley; Time Factors; Uterine Artery; Vasoconstriction; Vasodilation; Vasodilator Agents | 2010 |
Systemic antioxidant properties of L-carnitine in two different models of arterial hypertension.
Topics: Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Captopril; Carnitine; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2010 |
Beneficial effects of rosuvastatin on aortic adverse remodeling in nitric oxide-deficient rats.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Disease Models, Animal; Endothelial Cells; Fluorobenzenes; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Immunohistochemistry; Lipids; Microscopy, Electron, Transmission; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Pyrimidines; Rats; Rats, Wistar; Rosuvastatin Calcium; Sulfonamides; Tunica Intima | 2011 |
Acute intravenous injection and short-term oral administration of N(G) -nitro-L-arginine methyl ester to the rat provoke increased pressor responses to agonists and hypertension, but not inhibition of acetylcholine-induced hypotensive responses.
Topics: Acetylcholine; Administration, Oral; Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Hypotension; In Vitro Techniques; Injections, Intravenous; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Wistar; Vasoconstriction; Vasodilation | 2011 |
Nitric oxide-independent stimulation of soluble guanylate cyclase reduces organ damage in experimental low-renin and high-renin models.
Topics: Animals; Animals, Genetically Modified; Antihypertensive Agents; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Guanylate Cyclase; Heart; Hypertension; Kidney; Longevity; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; Nephrectomy; Nephritis, Interstitial; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyrazoles; Pyrimidines; Rabbits; Rats; Rats, Wistar; Renin; Signal Transduction | 2010 |
Enantioselective pharmacokinetic-pharmacodynamic modelling of carvedilol in a N-nitro-l-arginine methyl ester rat model of secondary hypertension.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Carbazoles; Carvedilol; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Inactivation, Metabolic; Male; Models, Biological; NG-Nitroarginine Methyl Ester; Propanolamines; Random Allocation; Rats; Rats, Wistar; Stereoisomerism; Sympatholytics | 2010 |
Observations of time-based measures of flow-mediated dilation of forearm conduit arteries: implications for the accurate assessment of endothelial function.
Topics: Adolescent; Adult; Analysis of Variance; Brachial Artery; Coronary Artery Disease; Endothelium, Vascular; Enzyme Inhibitors; Female; Heart Failure; Humans; Hypertension; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Regional Blood Flow; Smoking; Vasodilation | 2010 |
Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling.
Topics: Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Blotting, Western; Endothelium, Vascular; Hydrogen Peroxide; Hypertension; Mice; Mice, Transgenic; Muscle, Smooth, Vascular; NADH, NADPH Oxidoreductases; NADPH Oxidase 1; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Polymerase Chain Reaction; Up-Regulation; Vasodilation | 2010 |
L-NAME-treatment alters ectonucleotidase activities in kidney membranes of rats.
Topics: Adenosine Triphosphatases; Animals; Blood Pressure; Cell Membrane; Chromatography, High Pressure Liquid; Creatinine; Disease Models, Animal; Gene Expression; Heart Rate; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Myeloid mineralocorticoid receptor controls macrophage polarization and cardiovascular hypertrophy and remodeling in mice.
Topics: Aldosterone; Animals; Blood Pressure; Cardiomegaly; Cardiovascular Diseases; Fibrosis; Heart; Hypertension; Hypertrophy; Interleukin-4; Macrophages; Mice; Mice, Knockout; Mice, Transgenic; Mineralocorticoid Receptor Antagonists; NG-Nitroarginine Methyl Ester; Receptors, Glucocorticoid; Receptors, Mineralocorticoid | 2010 |
Effect of nuclear factor kappa B inhibition on L-NAME-induced hypertension and cardiovascular remodelling.
Topics: Acetylcysteine; Animals; Blood Pressure; Hypertension; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Ventricular Remodeling | 2010 |
Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF-β1 synthesis.
Topics: Animals; Arginine; Collagen; Endothelin-1; Enzyme Inhibitors; Fibrosis; Gene Expression Regulation; Hypertension; Hypoxia-Inducible Factor 1, alpha Subunit; Kidney; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Renal Insufficiency, Chronic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Transforming Growth Factor beta1 | 2011 |
Collagen XV is necessary for modeling of the extracellular matrix and its deficiency predisposes to cardiomyopathy.
Topics: Age Factors; Aging; Angiotensin II; Animals; Atrial Natriuretic Factor; Cardiomyopathies; Collagen; Coronary Circulation; Disease Models, Animal; Echocardiography; Elasticity; Enzyme Inhibitors; Extracellular Matrix; Female; Gene Expression Profiling; Gene Expression Regulation; Genotype; Heart Ventricles; Hemodynamics; Hypertension; Male; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Microscopy, Electron; Microscopy, Video; Myocardium; Natriuretic Peptide, Brain; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenotype; Polymerase Chain Reaction; RNA, Messenger; Telemetry; Ventricular Remodeling | 2010 |
Local and cardiorenal effects of periodontitis in nitric oxide-deficient hypertensive rats.
Topics: Alveolar Bone Loss; Animals; Disease Models, Animal; Enzyme Inhibitors; Free Radical Scavengers; Heart; Hypertension; Kidney; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Periodontitis; Peroxidase; Radiography; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2011 |
Perinatal L-arginine and antioxidant supplements reduce adult blood pressure but not ameliorate the altered vascular function in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Animals, Newborn; Antioxidants; Arginine; Blood Pressure; Cyclic N-Oxides; Dose-Response Relationship, Drug; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels | 2010 |
Piperine, active substance of black pepper, alleviates hypertension induced by NO synthase inhibition.
Topics: Alkaloids; Animals; Antibodies; Aorta, Thoracic; Benzodioxoles; Blood Pressure; Elastin; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar | 2010 |
Renin inhibition mitigates anti-angiogenesis in spontaneously hypertensive rats.
Topics: Amides; Angiopoietin-1; Angiopoietin-2; Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Fumarates; Hypertension; Male; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Signal Transduction; Ventricular Remodeling | 2011 |
[Integrated assessment of endothelio- and cardioprotective activity of macrolide antibiotics in nitric oxide deficiency model].
Topics: Animals; Anti-Bacterial Agents; Blood Pressure; Cardiotonic Agents; Disease Models, Animal; Endothelium, Vascular; Heart Function Tests; Hypertension; Macrolides; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Vasoconstriction | 2010 |
Hemodynamic responses to aortic depressor nerve stimulation in conscious L-NAME-induced hypertensive rats.
Topics: Angiotensin II; Animals; Aorta; Atenolol; Atropine Derivatives; Baroreflex; Blood Pressure; Electric Stimulation; Heart Rate; Hemodynamics; Hypertension; Male; NG-Nitroarginine Methyl Ester; Parasympatholytics; Prazosin; Rats; Rats, Wistar | 2011 |
Nitric oxide modulates reactivity to angiotensin II in internal mammary arterial grafts in hypertensive patients without associated risk factors.
Topics: Aged; Angiotensin II; Dose-Response Relationship, Drug; Endothelium, Vascular; Female; Humans; Hypertension; Male; Mammary Arteries; Membrane Potentials; Middle Aged; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitrites; Oxidative Stress; Vasoconstriction | 2011 |
Hypertension augments cardiac Toll-like receptor 4 expression and activity.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Cardiomegaly; Chemokine CCL2; Heparitin Sulfate; Hypertension; Interleukin-6; Myocardium; NG-Nitroarginine Methyl Ester; Ramipril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Toll-Like Receptor 4; Tumor Necrosis Factor-alpha; Up-Regulation | 2011 |
Systemic but not central nervous system nitric oxide synthase inhibition exacerbates the hypertensive effects of chronic melanocortin-3/4 receptor activation.
Topics: alpha-MSH; Analysis of Variance; Animals; Blood Glucose; Body Weight; Catheters, Indwelling; Eating; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Hypertension; Insulin; Leptin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides, Cyclic; Rats; Rats, Sprague-Dawley; Receptor, Melanocortin, Type 3; Receptor, Melanocortin, Type 4; Telemetry | 2011 |
Renal injury in angiotensin II+L-NAME-induced hypertensive rats is independent of elevated blood pressure.
Topics: Acute Kidney Injury; Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Kidney; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley | 2011 |
Amlodipine ameliorates endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats.
Topics: Acetylcholine; Amlodipine; Animals; Antihypertensive Agents; Ascorbic Acid; Blood Pressure; Endothelium, Vascular; Hypertension; Male; Malondialdehyde; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Nitrous Oxide; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Superoxides | 2011 |
Angiotensin-(1-7) blockade attenuates captopril- or hydralazine-induced cardiovascular protection in spontaneously hypertensive rats treated with NG-nitro-L-arginine methyl ester.
Topics: Angiotensin I; Angiotensin II; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Brain; Captopril; Cytokines; Heart; Hydralazine; Hypertension; In Vitro Techniques; Insulin; Kidney; Leptin; Male; Myocardial Contraction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Peptide Fragments; Perfusion; Proteinuria; Rats; Rats, Inbred SHR; Ventricular Function, Left | 2011 |
Cytosolic phospholipase A2alpha contributes to blood pressure increases and endothelial dysfunction under chronic NO inhibition.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Bone Marrow Transplantation; Disease Models, Animal; Dose-Response Relationship, Drug; Eicosanoids; Endothelium, Vascular; Enzyme Inhibitors; Group IV Phospholipases A2; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Renin; Time Factors; Tissue Culture Techniques; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2011 |
Contribution of renal purinergic receptors to renal vasoconstriction in angiotensin II-induced hypertensive rats.
Topics: Analysis of Variance; Angiotensin II; Animals; Arterioles; Blood Pressure; Blotting, Western; Glomerular Filtration Rate; Hemodynamics; Hypertension; Immunohistochemistry; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptors, Purinergic P2X1; Receptors, Purinergic P2Y1; Renal Circulation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Vasoconstriction | 2011 |
Antioxidant and vascular protective effects of curcumin and tetrahydrocurcumin in rats with L-NAME-induced hypertension.
Topics: Animals; Antioxidants; Blood Pressure; Blotting, Western; Curcumin; Glutathione; Hypertension; Lipid Peroxidation; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Vascular Resistance | 2011 |
Lisinopril attenuates renal oxidative injury in L-NAME-induced hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Catalase; Hypertension; Kidney; Lisinopril; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Oxidative Stress; Rats; Rats, Sprague-Dawley; Superoxide Dismutase | 2011 |
Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.
Topics: Amidohydrolases; Animals; Arginine; Blood Pressure; Cardiovascular Diseases; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Female; Genotype; Hypertension; Infusion Pumps, Implantable; Male; Mice; Mice, 129 Strain; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phenotype; Risk Factors; RNA Interference; Substrate Specificity; Time Factors; Transfection | 2011 |
Role of alpha adrenoceptors and nitric oxide on cardiovascular responses in acute and chronic hypertension.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Area Under Curve; Blood Pressure; Cardiovascular System; Electric Stimulation; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Prazosin; Rats; Rats, Wistar; Receptors, Adrenergic, alpha; Vagotomy; Yohimbine | 2011 |
Activation of NAD(P)H:quinone oxidoreductase ameliorates spontaneous hypertension in an animal model via modulation of eNOS activity.
Topics: Acetylcholine; AMP-Activated Protein Kinases; Animals; Antihypertensive Agents; Blood Pressure; Calcium; Cells, Cultured; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Humans; Hypertension; Male; Mice; NAD; NAD(P)H Dehydrogenase (Quinone); Naphthoquinones; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Phosphatidylinositol 3-Kinase; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; RNA Interference; Time Factors; Transfection; Vasodilation; Vasodilator Agents | 2011 |
Orchidectomy attenuates impaired endothelial effects of a high-salt diet in Sprague-Dawley rats.
Topics: Acetylcholine; Androgens; Animals; Aorta, Thoracic; Blood Pressure; Endothelium, Vascular; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Orchiectomy; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Testis; Testosterone; Vasodilation | 2011 |
Hypotensive effect of the water extract of the leaves of Pseuderanthemum palatiferum.
Topics: Acanthaceae; Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Plant Leaves; Rats; Rats, Sprague-Dawley; Vasodilation; Water | 2011 |
Different natriuretic responses in obese and lean rats in response to nitric oxide reduction.
Topics: Animals; Blood Pressure; Diuresis; Hypertension; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Obesity; Rats; Rats, Sprague-Dawley; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase | 2011 |
Aortic stiffness in vivo in hypertensive rat via echo-tracking: analysis of the pulsatile distension waveform.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Calcium Channel Blockers; Compliance; Diltiazem; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pulsatile Flow; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Processing, Computer-Assisted; Time Factors; Ultrasonography | 2011 |
Heme oxygenase-1 overexpression fails to attenuate hypertension when the nitric oxide synthase system is not fully operative.
Topics: Animals; Aorta; Blood Pressure; Carbon Monoxide; Cyclic GMP; Guanylate Cyclase; Heart Rate; Heme Oxygenase-1; Hemin; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protoporphyrins; Rats; Rats, Wistar; Receptors, Cytoplasmic and Nuclear; Soluble Guanylyl Cyclase | 2011 |
Relaxin ameliorates hypertension and increases nitric oxide metabolite excretion in angiotensin II but not N(ω)-nitro-L-arginine methyl ester hypertensive rats.
Topics: Albuminuria; Angiotensin II; Animals; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Relaxin | 2011 |
Contribution of nitric oxide synthase (NOS) activity in blood-brain barrier disruption and edema after acute ischemia/reperfusion in aortic coarctation-induced hypertensive rats.
Topics: Animals; Aortic Coarctation; Blood Pressure; Blood-Brain Barrier; Brain Edema; Cerebral Infarction; Cerebrovascular Circulation; Hypertension; Infarction, Middle Cerebral Artery; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Permeability; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2011 |
Modulation of the myogenic response in renal blood flow autoregulation by NO depends on endothelial nitric oxide synthase (eNOS), but not neuronal or inducible NOS.
Topics: Angiotensin II; Animals; Blood Pressure; Enzyme Inhibitors; Female; Homeostasis; Hypertension; Kidney; Male; Mesangial Cells; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Renal Circulation; Vascular Resistance; Vasoconstriction | 2011 |
Effects of pioglitazone and rosiglitazone on vascular function of mesenteric resistance arteries in rat genetic hypertension.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Endothelium, Vascular; Epinephrine; Fatty Acids, Unsaturated; Hydrazines; Hypertension; Hypoglycemic Agents; Indomethacin; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Pioglitazone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rosiglitazone; Thiazolidinediones; Thromboxane A2; Vascular Resistance; Vasoconstrictor Agents; Vasodilator Agents | 2011 |
Protective actions of nebivolol on chronic nitric oxide synthase inhibition-induced hypertension and chronic kidney disease in the rat: a comparison with angiotensin II receptor blockade.
Topics: Adrenergic beta-1 Receptor Antagonists; Angiotensin II Type 1 Receptor Blockers; Animals; Benzopyrans; Blotting, Western; Enzyme Inhibitors; Ethanolamines; Hydrogen Peroxide; Hypertension; Imidazoles; Kidney Failure, Chronic; Male; Nebivolol; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Superoxide Dismutase; Tetrazoles | 2012 |
Early life stress enhances angiotensin II-mediated vasoconstriction by reduced endothelial nitric oxide buffering capacity.
Topics: Angiotensin II; Animals; Animals, Newborn; Aorta, Thoracic; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Maternal Deprivation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Reactive Oxygen Species; Signal Transduction; Stress, Physiological; Vasoconstriction | 2011 |
Sildenafil preserves diastolic relaxation after reduction by L-NAME and increases phosphodiesterase-5 in the intercalated discs of cardiac myocytes and arterioles.
Topics: Animals; Arterioles; Blood Pressure; Cyclic Nucleotide Phosphodiesterases, Type 5; Diastole; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Heart; Hypertension; Male; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Phosphodiesterase 5 Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Time Factors | 2011 |
Renoprotective effects of combined endothelin-converting enzyme/neutral endopeptidase inhibitor SLV338 in acute and chronic experimental renal damage.
Topics: Acute Kidney Injury; Albuminuria; Animals; Aspartic Acid Endopeptidases; Constriction; Disease Models, Animal; Drug Evaluation, Preclinical; Endothelin-Converting Enzymes; Enzyme Inhibitors; Glomerulosclerosis, Focal Segmental; Hypertension; Kidney; Kidney Failure, Chronic; Male; Metalloendopeptidases; Nephrectomy; Neprilysin; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Reperfusion Injury | 2011 |
Carotid body remodelling in l-NAME-induced hypertension in the rat.
Topics: Animals; Biogenic Amines; Biomarkers; Blood Pressure; Carotid Body; Cell Nucleus; Disease Models, Animal; Enzyme Inhibitors; Fibrillar Collagens; Hypertension; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Proteoglycans; Rats; Rats, Wistar; Substance P; Vascular Endothelial Growth Factor A | 2012 |
Betulinic acid ameliorates endothelium-dependent relaxation in L-NAME-induced hypertensive rats by reducing oxidative stress.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Betulinic Acid; Data Interpretation, Statistical; Disease Models, Animal; Endothelium, Vascular; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Pentacyclic Triterpenes; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxide Dismutase; Triterpenes; Vasodilation | 2011 |
Chronic (-)-epicatechin improves vascular oxidative and inflammatory status but not hypertension in chronic nitric oxide-deficient rats.
Topics: Animals; Atherosclerosis; Blood Pressure; Catechin; Cyclooxygenase 2; Endothelium, Vascular; Hypertension; Hypertrophy; Inflammation; Inflammation Mediators; Kidney; Male; MAP Kinase Signaling System; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Phosphorylation; Phytotherapy; Plant Extracts; Prostaglandins; Proteinuria; Rats; Rats, Wistar; Up-Regulation; Vascular Diseases; Vasoconstriction | 2011 |
Upregulation of inducible nitric oxide synthase contributes to attenuated cutaneous vasodilation in essential hypertensive humans.
Topics: Administration, Cutaneous; Analysis of Variance; Blotting, Western; Case-Control Studies; Dose-Response Relationship, Drug; Female; Humans; Hypertension; Laser-Doppler Flowmetry; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitroprusside; Reference Values; Regional Blood Flow; Skin; Up-Regulation; Vasodilation | 2011 |
Veratric acid, a phenolic acid attenuates blood pressure and oxidative stress in L-NAME induced hypertensive rats.
Topics: Animals; Antioxidants; Biomarkers; Blood Pressure; Hypertension; Kidney; Lipid Peroxidation; Liver; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Oxidative Stress; Rats; Rats, Wistar; Vanillic Acid | 2011 |
Large BP-dependent and -independent differences in susceptibility to nephropathy after nitric oxide inhibition in Sprague-Dawley rats from two major suppliers.
Topics: Animals; Blood Pressure; Hypertension; Kidney Diseases; Kidney Glomerulus; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Proteinuria; Rats; Rats, Sprague-Dawley; Vasoconstriction | 2012 |
Effects of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, in L-NAME-induced hypertension in rats.
Topics: Anesthesia; Animals; Blood Pressure; Coordination Complexes; Disease Models, Animal; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Organometallic Compounds; Random Allocation; Rats; Rats, Wistar; Ruthenium; Treatment Outcome; Vasodilator Agents | 2011 |
The effect of indapamide on development of myocardial hypertrophy and fibrosis in L-NAME-induced hypertension in rat.
Topics: Animals; Captopril; Collagen Type I; Collagen Type III; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Indapamide; Male; Myocardium; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar | 2011 |
Antihypertensive and antioxidant potential of vanillic acid, a phenolic compound in L-NAME-induced hypertensive rats: a dose-dependence study.
Topics: Animals; Antihypertensive Agents; Antioxidants; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Vanillic Acid | 2011 |
Beneficial effects of Acer okamotoanum sap on L-NAME-induced hypertension-like symptoms in a rat model.
Topics: Acer; Animals; Antihypertensive Agents; Blood Pressure; Calcium; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Immunohistochemistry; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Plant Preparations; Potassium; Rats; Rats, Sprague-Dawley; Water | 2012 |
Tetrahydrocurcumin alleviates hypertension, aortic stiffening and oxidative stress in rats with nitric oxide deficiency.
Topics: Animals; Aorta; Curcumin; Endothelium, Vascular; Glutathione; Hemodynamics; Hypertension; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oxidative Stress; Protein Carbonylation; Rats; Rats, Sprague-Dawley; Superoxides; Vascular Resistance; Vascular Stiffness | 2012 |
Cardiac autonomic function in acutely nitric oxide deficient hypertensive rats: role of the sympathetic nervous system and oxidative stress.
Topics: Animals; Baroreflex; Heart; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Oxidopamine; Rats, Wistar; Sympathectomy, Chemical; Sympathetic Nervous System; Sympatholytics | 2011 |
Angiotensin II augments renal vasoconstriction via AT1 receptors in L-NAME-induced hypertensive rats.
Topics: Angiotensin II; Animals; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Vasoconstriction | 2009 |
Angiotensin II pressor response in the L-NAME-induced hypertensive pithed rat: role of the AT1 receptor.
Topics: Angiotensin II; Animals; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1 | 2009 |
Direct angiotensin II type 2 receptor stimulation in Nω-nitro-L-arginine-methyl ester-induced hypertension: the effect on pulse wave velocity and aortic remodeling.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Flow Velocity; Blood Pressure; Body Weight; Collagen; Disease Models, Animal; Hydroxyproline; Hypertension; Imidazoles; Male; NG-Nitroarginine Methyl Ester; Olmesartan Medoxomil; Pulsatile Flow; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Sulfonamides; Tetrazoles; Thiophenes; Vascular Stiffness | 2012 |
Crosstalk between central pathways of nitric oxide and carbon monoxide in the hypertensive action of cyclosporine.
Topics: Animals; Carbon Monoxide; Cyclosporine; Guanylate Cyclase; Heart Rate; Heme Oxygenase (Decyclizing); Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Signal Transduction | 2012 |
Single atom substitution in mouse protein kinase G eliminates oxidant sensing to cause hypertension.
Topics: Acetylcholine; Animals; Biological Factors; Blood Pressure; Cyclic GMP-Dependent Protein Kinase Type I; Cyclic GMP-Dependent Protein Kinases; Electromyography; Epoprostenol; Heart Rate; Hydrogen Peroxide; Hypertension; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mutagenesis, Site-Directed; NG-Nitroarginine Methyl Ester; Nitric Oxide; Signal Transduction; Vasodilation | 2012 |
Blunted blood pressure response and elevated plasma adiponectin levels in female Sprague Dawley rats.
Topics: Adiponectin; Animals; Blood Pressure; Disease Models, Animal; Female; Fructose; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Sex Characteristics; Sodium Chloride, Dietary; Stress, Physiological; Testosterone | 2012 |
Short-term ACE inhibition confers long-term protection against target organ damage.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Cell Proliferation; Creatinine; Disease Models, Animal; Enalapril; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Kidney; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Urea | 2012 |
Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling.
Topics: Acetylcholine; Animals; Biological Factors; Cyclooxygenase Inhibitors; Endothelial Cells; Endothelin Receptor Antagonists; Endothelium, Vascular; Gene Knockout Techniques; GTP-Binding Protein alpha Subunits, Gi-Go; Hemodynamics; Hypertension; In Vitro Techniques; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Pertussis Toxin; RGS Proteins; Signal Transduction; Vasodilation; Vasodilator Agents | 2012 |
Effect of veratric acid on the cardiovascular risk of L-NAME-induced hypertensive rats.
Topics: Animals; Blood Pressure; Cardiovascular Diseases; Cholesterol, HDL; Disease Models, Animal; Heart Rate; Hydroxymethylglutaryl CoA Reductases; Hyperlipidemias; Hypertension; Kidney; Lipid Metabolism; Lipids; Lipoproteins; Liver; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Risk Factors; Vanillic Acid | 2012 |
Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy.
Topics: Animals; Biomarkers; Blood Pressure; Cell Adhesion Molecules; Disease Progression; Gene Expression Regulation; Humans; Hypertension; Kidney Diseases; Kidney Transplantation; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Transplantation, Homologous; Vascular Diseases | 2012 |
Enhanced vasorelaxant effects of the endocannabinoid-like mediator, oleamide, in hypertension.
Topics: Amidohydrolases; Animals; Aorta; Benzamides; Biomimetic Materials; Cannabinoid Receptor Modulators; Capsaicin; Carbamates; Cyclooxygenase Inhibitors; Endocannabinoids; Endothelium, Vascular; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Oleic Acids; Rats; Receptor, Cannabinoid, CB1; TRPV Cation Channels; Vasodilator Agents | 2012 |
Mice lacking macrophage 12/15-lipoxygenase are resistant to experimental hypertension.
Topics: Animals; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Hypertension; Macrophages; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Vasodilation | 2012 |
Role of propolis on tyrosine hydroxylase activity and blood pressure in nitric oxide synthase-inhibited hypertensive rats.
Topics: Animals; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Propolis; Rats; Rats, Wistar; Tyrosine 3-Monooxygenase | 2012 |
Antidiabetic and antihypertensive effect of a polyphenol-rich fraction of Thymelaea hirsuta L. in a model of neonatal streptozotocin-diabetic and N(G) -nitro-l-arginine methyl ester-hypertensive rats.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Female; Glucose; Hypertension; Hypoglycemic Agents; Jejunum; Liver; Liver Glycogen; Male; NG-Nitroarginine Methyl Ester; Phytotherapy; Plant Extracts; Polyphenols; Rats; Rats, Wistar; Streptozocin; Thymelaeaceae; Time Factors; Treatment Outcome | 2012 |
[Correction of endothelial dysfunction by L-arginine under experimental pre-eclampsia conditions].
Topics: Albuminuria; Animals; Arginine; Blood Pressure; Endothelium; Female; Humans; Hypertension; Injections, Intraperitoneal; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Placenta; Pre-Eclampsia; Pregnancy; Rats | 2012 |
Chlorella pyrenoidosa ameliorated L-NAME-induced hypertension and cardiorenal remodeling in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Blood Pressure; Chlorella; Cytochrome P-450 CYP4A; Heart; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phytotherapy; Plant Preparations; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha | 2013 |
Chronic reduction of nitric oxide level in adult spontaneously hypertensive rats induces aortic stiffness similar to old spontaneously hypertensive rats.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Blood Pressure; Clonidine; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Perindopril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Stiffness | 2012 |
Individual and concomitant effects of cardioprotective programs on cardiac apelinergic system and oxidative state in L-NAME-induced hypertension.
Topics: Animals; Antioxidants; Apelin; Apelin Receptors; Biomarkers; C-Reactive Protein; Cardiotonic Agents; Dietary Supplements; Ferula; Hypertension; Intercellular Signaling Peptides and Proteins; Male; Malondialdehyde; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Peptidyl-Dipeptidase A; Physical Conditioning, Animal; Rats; Rats, Wistar; Receptors, G-Protein-Coupled | 2013 |
A role for nitric oxide within the nucleus tractus solitarii in the development of muscle mechanoreflex dysfunction in hypertension.
Topics: Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Ganglionic Blockers; Heart Rate; Hexamethonium; Hypertension; Male; Mechanotransduction, Cellular; Microdialysis; Muscle Spindles; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reflex, Stretch; Solitary Nucleus; Time Factors | 2012 |
Effect of Viscum articulatum Burm. (Loranthaceae) in Nω-nitro-L-arginine methyl ester induced hypertension and renal dysfunction.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cholesterol; Creatinine; Drugs, Chinese Herbal; Enalapril; Hypertension; Kidney Diseases; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phytotherapy; Potassium; Rats; Rats, Wistar; Renal Agents; Urination; Viscum | 2012 |
KCa 3.1 channels maintain endothelium-dependent vasodilatation in isolated perfused kidneys of spontaneously hypertensive rats after chronic inhibition of NOS.
Topics: Acetylcholine; Animals; Apamin; Biological Factors; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Indoles; Indomethacin; Intermediate-Conductance Calcium-Activated Potassium Channels; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Nitroprusside; Oximes; Potassium Channel Blockers; Pyrazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 2012 |
Macrophage mineralocorticoid receptor signaling plays a key role in aldosterone-independent cardiac fibrosis.
Topics: Aldosterone; Angiotensin Amide; Animals; Fibrosis; Heart; Hypertension; Macrophages; Male; Mice; Mice, Knockout; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenotype; Receptors, Mineralocorticoid; Signal Transduction; Time Factors | 2012 |
Tension cost correlates with mechanical and biochemical parameters in different myocardial contractility conditions.
Topics: Animals; Desoxycorticosterone; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Hypertension; Male; Myocardial Contraction; Myocardial Infarction; Nephrectomy; NG-Nitroarginine Methyl Ester; Papillary Muscles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Ventricular Function, Left; Ventricular Myosins | 2012 |
Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats.
Topics: Administration, Oral; Animals; Anti-Ulcer Agents; Antihypertensive Agents; Aorta; Benzoates; Blood Pressure; Free Radical Scavengers; Gastric Juice; Hydrogen-Ion Concentration; Hypertension; Imidazoles; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Omeprazole; Rats; Rats, Wistar; S-Nitrosothiols; Sodium Nitrite; Vasodilation | 2012 |
Erythropoietin attenuated vascular dysfunction and inflammation by inhibiting NADPH oxidase-derived superoxide production in nitric oxide synthase-inhibited hypertensive rat aorta.
Topics: Acetylcholine; Adventitia; Animals; Aorta; Blood Pressure; Body Weight; Erythropoietin; Gene Expression Regulation; Hematocrit; Heme Oxygenase-1; Humans; Hypertension; Inflammation; Macrophages; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Osteopontin; Phosphoproteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides; Suppressor of Cytokine Signaling 1 Protein; Suppressor of Cytokine Signaling Proteins | 2012 |
Novel diallyldisulfide analogs ameliorate cardiovascular remodeling in rats with L-NAME-induced hypertension.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Calcium; Cyclic GMP; Disulfides; Eating; Gene Expression Regulation, Enzymologic; Hypertension; Male; Muscle, Smooth, Vascular; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Vasoconstriction | 2012 |
Protection against L-NAME-induced reduction in cardiac output persists even after cessation of angiotensin-converting enzyme inhibitor treatment.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arterial Pressure; Cardiac Output; Coronary Circulation; Drug Interactions; Enalapril; Enzyme Inhibitors; Heart Diseases; Heart Function Tests; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Time Factors; Ventricular Remodeling | 2013 |
Exercise training prevents ecto-nucleotidases alterations in platelets of hypertensive rats.
Topics: 5'-Nucleotidase; Adenosine Deaminase; Adenosine Diphosphate; Adenosine Triphosphate; Animals; Blood Platelets; Hydrolysis; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Conditioning, Animal; Platelet Aggregation; Platelet Count; Rats; Rats, Wistar | 2012 |
Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: role of endothelium-derived factors.
Topics: Animals; Antihypertensive Agents; Arterioles; Blood Flow Velocity; Blood Pressure; Cats; Cyclooxygenase Inhibitors; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Female; Heart Rate; Hypertension; Intraocular Pressure; Intravitreal Injections; Laser-Doppler Flowmetry; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Retinal Artery; rho-Associated Kinases; Vasodilator Agents | 2012 |
Effects of lisinopril on NMDA receptor subunits 2A and 2B levels in the hippocampus of rats with L-NAME-induced hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Hippocampus; Humans; Hypertension; Lipid Peroxidation; Lisinopril; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Renin-Angiotensin System | 2012 |
Physical training prevents oxidative stress in L-NAME-induced hypertension rats.
Topics: Animals; Ascorbic Acid; Biomarkers; Blood Pressure; Body Weight; Catalase; Heart Rate; Hypertension; Kidney; Lipid Peroxidation; Lipids; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidation-Reduction; Oxidative Stress; Physical Conditioning, Animal; Protein Carbonylation; Rats; Rats, Wistar; Sulfhydryl Compounds; Superoxide Dismutase; Swimming; Systole; Thiobarbituric Acid Reactive Substances | 2013 |
Reduction of nitric oxide-mediated γ-amino butyric acid release in rostral ventrolateral medulla is involved in superoxide-induced sympathoexcitation of hypertensive rats.
Topics: Animals; Arterial Pressure; Bicuculline; Cyclic N-Oxides; Disease Models, Animal; Down-Regulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Free Radical Scavengers; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Heart Rate; Hypertension; Kidney; Kynurenic Acid; Male; Medulla Oblongata; Microdialysis; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Spin Labels; Superoxides; Sympathetic Nervous System; Time Factors | 2012 |
Antihypertensive effect of boysenberry seed polyphenols on spontaneously hypertensive rats and identification of orally absorbable proanthocyanidins with vasorelaxant activity.
Topics: Absorption; Administration, Oral; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Plant Extracts; Proanthocyanidins; Rats; Rats, Inbred SHR; Rosaceae; Seeds; Tissue Culture Techniques; Vasodilator Agents | 2012 |
Blood pressure-lowering effect of dietary (-)-epicatechin administration in L-NAME-treated rats is associated with restored nitric oxide levels.
Topics: Animals; Blood Pressure; Catechin; Dietary Supplements; Glutathione; Glutathione Disulfide; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Vasodilation | 2012 |
Antihypertensive and cardioprotective effects of the Lagenaria siceraria fruit in NG-nitro-L-arginine methyl ester (L-NAME) induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Antioxidants; Apigenin; Blood Pressure; Cardiotonic Agents; Cholesterol; Chromatography, High Pressure Liquid; Cucurbitaceae; Disease Models, Animal; Flavonoids; Fruit; Glucosides; Hypertension; Inflammation; Luteolin; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar | 2012 |
Sodium nitrite therapy rescues ischemia-induced neovascularization and blood flow recovery in hypertension.
Topics: Allopurinol; Angiotensin II; Animals; Arterial Pressure; Capillaries; Cyclic AMP; Cyclic GMP; Femoral Artery; Hindlimb; Hypertension; Indoles; Ischemia; Male; Mice; Mice, Inbred C57BL; Muscle, Skeletal; Neovascularization, Pathologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Proto-Oncogene Proteins c-akt; Pyrroles; Receptors, Vascular Endothelial Growth Factor; Regional Blood Flow; Sodium Nitrite; Xanthine Dehydrogenase | 2012 |
Effect of treadmill exercise and Ferula gummosa on myocardial HSP72, vascular function, and antioxidant defenses in spontaneously hypertensive rats.
Topics: Animals; Antioxidants; Biomarkers; Cardiovascular System; Disease Models, Animal; Ferula; Glutathione Reductase; HSP72 Heat-Shock Proteins; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Peptidyl-Dipeptidase A; Physical Conditioning, Animal; Plant Extracts; Protein Carbonylation; Rats; Rats, Wistar | 2013 |
Syringic acid ameliorates (L)-NAME-induced hypertension by reducing oxidative stress.
Topics: Animals; Antioxidants; Biomarkers; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Gallic Acid; Hypertension; Kidney Function Tests; Lipid Peroxidation; Liver Function Tests; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Wistar | 2012 |
Maternal hypertension induced by NO blockade does not program adult metabolic diseases in growth-restricted rat fetuses.
Topics: Animals; Animals, Newborn; Blood Glucose; Blood Pressure; Body Weight; Eating; Enzyme Inhibitors; Female; Fetal Growth Retardation; Glucose Tolerance Test; Hypertension; Male; Metabolic Diseases; NG-Nitroarginine Methyl Ester; Organ Size; Pregnancy; Pregnancy Complications, Cardiovascular; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar | 2013 |
The renoprotective effect of L-carnitine in hypertensive rats is mediated by modulation of oxidative stress-related gene expression.
Topics: Animals; Antioxidants; Carnitine; Down-Regulation; Gene Expression Regulation; Glutathione Peroxidase; Glutathione Reductase; Hypertension; Kidney; Lipid Peroxidation; Male; NADPH Oxidases; NF-E2-Related Factor 2; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidative Stress; PPAR alpha; Rats; Rats, Wistar; Renin-Angiotensin System; Superoxide Dismutase; Superoxides; Up-Regulation | 2013 |
L-Carnitine protects against arterial hypertension-related cardiac fibrosis through modulation of PPAR-γ expression.
Topics: Animals; Antihypertensive Agents; Carnitine; Collagen Type I; Collagen Type II; Connective Tissue Growth Factor; Fibrosis; Hypertension; Male; Membrane Glycoproteins; Myocardium; NADPH Oxidase 2; NADPH Oxidase 4; NADPH Oxidases; NG-Nitroarginine Methyl Ester; PPAR gamma; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2013 |
Antihypertensive and renoprotective actions of soluble epoxide hydrolase inhibition in ANG II-dependent malignant hypertension are abolished by pretreatment with L-NAME.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Epoxide Hydrolases; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Transgenic; Thiobarbituric Acid Reactive Substances | 2013 |
Pre-weaning growth hormone treatment reverses hypertension and endothelial dysfunction in adult male offspring of mothers undernourished during pregnancy.
Topics: Acetylcholine; Adult; Animals; Apamin; Blood Pressure; Carbenoxolone; Female; Growth Hormone; Humans; Hypertension; Male; Malnutrition; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Phenylephrine; Pregnancy; Pyrazoles; Rats; Rats, Sprague-Dawley; Time Factors; Vasoconstriction; Vasodilation; Weaning | 2013 |
Impaired pressure natriuresis resulting in salt-sensitive hypertension is caused by tubulointerstitial immune cell infiltration in the kidney.
Topics: Animals; Blood Pressure; Hypertension; Kidney Tubules; Male; Natriuresis; Nephritis; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Sodium Chloride, Dietary | 2013 |
Acute and chronic antihypertensive effects of Cinnamomum zeylanicum stem bark methanol extract in L-NAME-induced hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta; Atherosclerosis; Blood Pressure; Cinnamomum zeylanicum; Heart; Hypertension; Lipids; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Rats; Rats, Wistar | 2013 |
Zn deficiency aggravates hypertension in spontaneously hypertensive rats: possible role of Cu/Zn-superoxide dismutase.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Blotting, Western; Cyclic N-Oxides; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Rats; Rats, Inbred SHR; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Spin Labels; Superoxide Dismutase; Superoxides; Zinc | 2002 |
Nipradilol prevents L-NAME-exacerbated nephrosclerosis with decreasing of caspase-3 expression in SHR.
Topics: Adrenergic beta-Antagonists; Animals; Apoptosis; Blood Pressure; Caspase 3; Caspases; Hypertension; Male; Nephrosclerosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Proliferating Cell Nuclear Antigen; Propanolamines; Rats; Rats, Inbred SHR; Rats, Wistar | 2002 |
Hemostasis imbalance in experimental hypertension.
Topics: Animals; Anticoagulants; Arteries; Blood Platelets; Blood Pressure; Body Weight; Enzyme Inhibitors; Fibrinolytic Agents; Heart; Hemostasis; Hypertension; Kidney Glomerulus; Lipoproteins; Male; NG-Nitroarginine Methyl Ester; Organ Size; Plasminogen Activator Inhibitor 1; Platelet Activation; Random Allocation; Rats; Rats, Wistar; Thrombin; Thromboplastin; Tissue Plasminogen Activator | 2002 |
Inhibitor for advanced glycation end products formation attenuates hypertension and oxidative damage in genetic hypertensive rats.
Topics: Animals; Blood Pressure; Circadian Rhythm; Enzyme Inhibitors; Glycation End Products, Advanced; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidation-Reduction; Rats; Rats, Inbred SHR; RNA, Messenger; Thiadiazoles; Thiazolidines | 2002 |
Enalapril and quinapril improve endothelial vasodilator function and aortic eNOS gene expression in L-NAME-treated rats.
Topics: 6-Ketoprostaglandin F1 alpha; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Dose-Response Relationship, Drug; Enalapril; Endothelium, Vascular; Hypertension; In Vitro Techniques; Isoquinolines; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Quinapril; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrahydroisoquinolines; Time Factors; Vasodilation; Vasodilator Agents | 2002 |
Coronary effects of endothelin-1 during acute hypertension in anaesthetized goats.
Topics: Acute Disease; Animals; Coronary Circulation; Endothelin-1; Enzyme Inhibitors; Female; Goats; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Vascular Resistance; Vasoconstrictor Agents | 2002 |
Effects of nitric oxide on P2Y receptor resensitization in spontaneously hypertensive rat mesangial cells.
Topics: Adenosine Triphosphate; Animals; Arginine; Calcium; Cells, Cultured; Cyclic GMP; Cytosol; Enzyme Inhibitors; Glomerular Mesangium; Guanylate Cyclase; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrogen Oxides; Osmolar Concentration; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Purinergic P2; Spermine | 2002 |
N(G)-nitro-L-arginine methyl ester-induced hypertension and natriuretic peptide gene expression: inhibition by angiotensin II type 1 receptor antagonism.
Topics: Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Enzyme Inhibitors; Gene Expression Regulation; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin | 2002 |
In vivo effects of the controlled NO donor/scavenger ruthenium cyclam complexes on blood pressure.
Topics: Animals; Blood Pressure; Cell Division; Cyclic N-Oxides; Free Radical Scavengers; Heterocyclic Compounds; Hypertension; Hypotension; Imidazoles; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Rats, Wistar; Ruthenium | 2002 |
Effects of Cudrania tricuspidata water extract on blood pressure and renal functions in NO-dependent hypertension.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Blotting, Western; Body Weight; Creatinine; Cyclic GMP; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Plant Bark; Plant Extracts; Rats; Rats, Sprague-Dawley; Sodium | 2002 |
Ouabain-induced hypertension is accompanied by increases in endothelial vasodilator factors.
Topics: Animals; Biological Factors; Blood Pressure; Cardiotonic Agents; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Guanidines; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ouabain; Phenylephrine; Potassium Channel Blockers; Rats; Rats, Wistar; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2002 |
Beneficial effect of pentaerythrityl tetranitrate on functional and morphological changes in the rat thoracic aorta evoked by long-term nitric oxide synthase inhibition.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Pentaerythritol Tetranitrate; Rats; Rats, Wistar; Time Factors; Vasodilator Agents | 2002 |
Renal antioxidant status in rats with hypertension induced by N sup omega nitro-L-arginine methyl ester.
Topics: Animals; Antioxidants; Blood Pressure; Catalase; Enzyme Inhibitors; Free Radical Scavengers; Glutathione Peroxidase; Hypertension; Kidney; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Superoxide Dismutase | 2002 |
Cardiovascular system of offsprings of hypertensive rats with defective nitric oxide production.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Enzyme Inhibitors; Female; Heart; Heart Rate; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ornithine Decarboxylase; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Inbred WKY; Vasodilator Agents | 2002 |
Blood pressure lowering effect of an olive leaf extract (Olea europaea) in L-NAME induced hypertension in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Olea; Phytotherapy; Plant Extracts; Plant Leaves; Rats; Rats, Wistar | 2002 |
Evaluation of the involvement of nitric oxide and substance P in reducing baroreflex gain in the genetically hypertensive (GH) rat.
Topics: Animals; Baroreflex; Blood Pressure; Diterpenes; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Neurokinin-1 Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Piperidines; Quinuclidines; Rats; Rats, Inbred SHR; Rest; Substance P; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
Ouabain changes arterial blood pressure and vascular reactivity to phenylephrine in L-NAME-induced hypertension.
Topics: Animals; Blood Pressure; Drug Synergism; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Ouabain; Phenylephrine; Potassium Channels; Rats; Rats, Wistar | 2003 |
Discoordinate re-expression of cardiac fetal genes in N(omega)-nitro-L-arginine methyl ester (L-NAME) hypertension.
Topics: Animals; Atrial Natriuretic Factor; Enzyme Inhibitors; Gene Expression Regulation; Heart Ventricles; Hypertension; Male; Myocardium; Myosin Heavy Chains; Natriuretic Peptide, Brain; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger | 2003 |
Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats.
Topics: Acetylcholine; Animals; Aorta; Arterioles; Blood Pressure; Carboxyhemoglobin; Culture Techniques; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension; Immunohistochemistry; Male; Mesoporphyrins; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred Dahl; Vasodilator Agents | 2003 |
Impaired response to insulin associated with protein kinase C in chronic fructose-induced hypertension.
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Enzyme Activators; Enzyme Inhibitors; Fructose; Hypertension; Hypoglycemic Agents; Insulin; Insulin Resistance; Male; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Rats, Sprague-Dawley | 2002 |
The serpin protease-nexin 1 is present in rat aortic smooth muscle cells and is upregulated in L-NAME hypertensive rats.
Topics: Administration, Oral; Amyloid beta-Protein Precursor; Angiotensin II; Animals; Aorta; Calcium; Carrier Proteins; Cell Division; Cells, Cultured; Humans; Hypertension; Immunohistochemistry; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Protease Nexins; Rats; Rats, Wistar; Receptors, Cell Surface; Recombinant Proteins; Serpin E2; Serpins; Thrombin; Up-Regulation | 2003 |
Anti-pressor effects of whole body exposure to static magnetic field on pharmacologically induced hypertension in conscious rabbits.
Topics: Animals; Arteries; Blood Pressure; Ear; Electromagnetic Fields; Hypertension; Male; NG-Nitroarginine Methyl Ester; Norepinephrine; Plethysmography; Rabbits; Reference Values; Vasoconstriction; Whole-Body Irradiation | 2003 |
Angiotensin II and renal medullary blood flow in Lyon rats.
Topics: Angiotensin II; Animals; Bradykinin; Bradykinin Receptor Antagonists; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Hypertension; Indomethacin; Kidney Medulla; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Rats; Rats, Inbred Strains; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptor, Bradykinin B2; Receptors, Angiotensin; Reference Values; Renal Circulation; Vasoconstrictor Agents | 2003 |
Pressure natriuresis in AT(2) receptor-deficient mice with L-NAME hypertension.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Glomerular Filtration Rate; Hypertension; Mice; Mice, Knockout; Natriuresis; NG-Nitroarginine Methyl Ester; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Circulation | 2003 |
Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; Lod Score; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentolinium Tartrate; Quantitative Trait Loci; Quantitative Trait, Heritable; Rats; Rats, Wistar; Renin-Angiotensin System; Sympathetic Nervous System | 2003 |
Nitric oxide opposes glucose-induced hypertension by suppressing sympathetic activity.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Blood Pressure; Enzyme Inhibitors; Glucose; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Renin; Sympathetic Nervous System | 2003 |
Administration of N(omega)-L-arginine methyl ester (L-NAME) impairs endothelium-dependent relaxation in gravid but not nongravid rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Delivery, Obstetric; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; In Vitro Techniques; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pre-Eclampsia; Pregnancy; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2003 |
Endothelium-dependent relaxation in pulmonary arteries of L-NAME-treated Wistar and stroke-prone spontaneously hypertensive rats.
Topics: Animals; Arginine; Blood Pressure; Body Weight; Cardiovascular Agents; Endothelium, Vascular; Enzyme Inhibitors; Genetic Predisposition to Disease; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitroarginine; Nitroprusside; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Stroke; Vasodilation | 2002 |
Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Amides; Angiotensin II; Animals; Cells, Cultured; Cyclic GMP; Endothelin-1; Enzyme Activation; Enzyme Inhibitors; Hypertension; Indoles; Intracellular Signaling Peptides and Proteins; Maleimides; Muscle Proteins; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; NG-Nitroarginine Methyl Ester; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Threonine | 2003 |
A nitric oxide-generating beta-blocking agent prevents renal injury in the rat remnant kidney model. Comparative study of two beta-blocking drugs, nipradilol and propranolol.
Topics: Adrenergic beta-Antagonists; Animals; Cyclic GMP; Enzyme Inhibitors; Hypertension; Kidney; Kidney Diseases; Kidney Glomerulus; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Propanolamines; Propranolol; Proteinuria; Rats; Rats, Inbred F344; Renin | 2003 |
Do COX-2 inhibitors really prevent hypertension and proteinuria? Another brick in the wall for the COX-2 inhibition and cardiovascular disease controversy.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Hypertension; Isoenzymes; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Proteinuria; Rats | 2003 |
Inhibition of COX-2 prevents hypertension and proteinuria associated with a decrease of 8-iso-PGF2alpha formation in L-NAME-treated rats.
Topics: Animals; Base Sequence; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprost; DNA, Complementary; F2-Isoprostanes; Hemodynamics; Hypertension; Isoenzymes; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Proteinuria; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sulfonamides | 2003 |
Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Biphenyl Compounds; Glomerular Filtration Rate; Heart; Hypertension; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Renal Insufficiency; Ventricular Fibrillation | 2003 |
Structure, function, and endothelium-derived hyperpolarizing factor in the caudal artery of the SHR and WKY rat.
Topics: Acetylcholine; Animals; Apamin; Arteries; Biological Factors; Charybdotoxin; Endothelium, Vascular; Gap Junctions; Hyperplasia; Hypertension; Indomethacin; Male; Membrane Potentials; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Peptides; Potassium Channels, Calcium-Activated; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tail; Vasodilation | 2003 |
Evaluation of systemic blood NO dynamics by EPR spectroscopy: HbNO as an endogenous index of NO.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Calibration; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Hemoglobins; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Thiazepines | 2003 |
Characteristics of 24 h telemetered blood pressure in eNOS-knockout and C57Bl/6J control mice.
Topics: Animals; Blood Pressure; Circadian Rhythm; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Telemetry | 2003 |
Hypertension: does impaired endothelium-dependent relaxation affect superoxide scavenging?
Topics: Animals; Blood Pressure; Catalase; Copper; Endothelium, Vascular; Free Radical Scavengers; Heart Rate; Hypertension; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Reactive Oxygen Species; Superoxide Dismutase; Superoxides; Vasodilation; Zinc | 2002 |
Mislocalization of eNOS and upregulation of cerebral vascular Ca2+ channel activity in angiotensin-hypertension.
Topics: Angiotensin II; Animals; Blotting, Western; Calcium Channels; Calcium Channels, L-Type; Cerebral Arteries; Enzyme Inhibitors; Female; Fluorescein; Hypertension; Membrane Potentials; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred WKY; Up-Regulation | 2003 |
Different effects of acute clenbuterol on vasomotor response in mesenteric arteries from young and old spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Aging; Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Capsaicin; Clenbuterol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Norepinephrine; Phentolamine; Propranolol; Rats; Rats, Inbred SHR; Tetrodotoxin; Tritium; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2003 |
The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats.
Topics: 4-Aminopyridine; Adrenalectomy; Adrenergic Antagonists; Amifampridine; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Indomethacin; Losartan; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Potassium Channel Blockers; Prazosin; Protein Kinase C; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Endothelin A; Staurosporine; Sulfonamides; Vascular Resistance; Vasoconstriction | 2003 |
Chronic inhibition of nitric oxide synthase induces hypertension and cardiomyocyte mitochondrial and myocardial collagen remodelling in the absence of hypertrophy.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Collagen; Disease Models, Animal; Enzyme Inhibitors; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Male; Mitochondria, Heart; Models, Cardiovascular; Myocardium; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Predictive Value of Tests; Randomized Controlled Trials as Topic; Rats; Rats, Wistar; Severity of Illness Index; Time Factors; Treatment Outcome | 2003 |
Kidneys in hypertensive rats show reduced response to nitric oxide synthase inhibition as evaluated by BOLD MRI.
Topics: Animals; Hypertension; Kidney; Magnetic Resonance Imaging; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors | 2003 |
Influence of hypertension on cardiac contractile response of human erythrocyte-derived depressing factor in ventricular myocytes.
Topics: Animals; Biological Factors; Calcium; Enzyme Inhibitors; Erythrocytes; Humans; Hypertension; In Vitro Techniques; Male; Myocardial Contraction; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2003 |
Effect of aluminum on the blood-brain barrier permeability during nitric oxide-blockade-induced chronic hypertension in rats.
Topics: Aluminum; Animals; Blood Pressure; Blood-Brain Barrier; Body Weight; Chronic Disease; Coloring Agents; Enzyme Inhibitors; Evans Blue; Hypertension; Indicators and Reagents; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2003 |
Nebivolol ameliorates nitric oxide deficient hypertension.
Topics: Adrenergic beta-1 Receptor Antagonists; Animals; Antihypertensive Agents; Benzopyrans; Dose-Response Relationship, Drug; Drug Administration Schedule; Ethanolamines; Hypertension; Male; Nebivolol; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System | 2002 |
Hypertensive response to chronic NG-nitro-L-arginine methyl ester (L-NAME) treatment is similar in immature and adult Wistar rats.
Topics: Aging; Animals; Aorta; Heart Ventricles; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sodium Chloride, Dietary; Weaning | 2003 |
Role of oxidative stress in age-related reduction of NO-cGMP-mediated vascular relaxation in SHR.
Topics: Aging; Animals; Aorta, Thoracic; Blood Pressure; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Phenylephrine; Rats; Rats, Inbred SHR; Vasoconstrictor Agents; Vasodilation | 2003 |
Effect of hyperhomocystinemia and hypertension on endothelial function in methylenetetrahydrofolate reductase-deficient mice.
Topics: Acetylcholine; Angiotensin II; Animals; Aorta; Biological Availability; Endothelium, Vascular; Hyperhomocysteinemia; Hypertension; In Vitro Techniques; Mesenteric Arteries; Methylenetetrahydrofolate Reductase (NADPH2); Mice; Mice, Knockout; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Superoxides; Vasodilation; Xanthine Oxidase | 2003 |
Antihypertensive effects of onion on NO synthase inhibitor-induced hypertensive rats and spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diet; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Onions; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances | 2003 |
Control of arterial pressure by angiotensin II and nitric oxide at the onset of diabetes.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Experimental; Enalapril; Hypertension; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 2003 |
Endothelial-independent prevention of high blood pressure in L-NAME-treated rats by angiotensin II type I receptor antisense gene therapy.
Topics: Animals; Cardiomegaly; DNA, Antisense; Endothelium, Vascular; Enzyme Inhibitors; Genetic Therapy; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Retroviridae | 2003 |
Effect of polyphenolic compounds on the renal Na(+),K(+)-ATPase during the restoration of normotension after experimentally induced hypertension in rats.
Topics: Adenosine Triphosphate; Animals; Blood Pressure; Enzyme Inhibitors; Flavonoids; Hypertension; Kidney; Kinetics; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenols; Polyphenols; Rats; Rats, Inbred WKY; Sodium-Potassium-Exchanging ATPase | 2003 |
Erythrocyte ion transport and membrane lipid composition in young and adult rats with NO-deficient hypertension.
Topics: Animals; Biological Transport, Active; Disease Models, Animal; Erythrocyte Membrane; Erythrocytes; Hypertension; Ion Transport; Male; Membrane Lipids; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Potassium; Rats; Rats, Wistar; Sodium; Sodium-Potassium-Exchanging ATPase | 2003 |
NADPH oxidase-derived superoxide augments endothelin-1-induced venoconstriction in mineralocorticoid hypertension.
Topics: Acetophenones; Allopurinol; Animals; Atrasentan; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Mineralocorticoid; Superoxides; Vasoconstriction; Vasoconstrictor Agents; Venae Cavae; Viper Venoms; Xanthine Oxidase | 2003 |
Involvement of cholinoceptors in cadmium-induced endothelial dysfunction.
Topics: Acetylcholine; Administration, Oral; Animals; Aorta, Thoracic; Atropine; Cadmium; Calcimycin; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Gallamine Triethiodide; Glomerular Filtration Rate; Hypertension; Indomethacin; Kidney Cortex; Kidney Diseases; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Peripheral Vascular Diseases; Phenylephrine; Pirenzepine; Prostaglandins; Rats; Rats, Wistar; Receptor, Muscarinic M1; Vasodilation | 2003 |
SR141716A-sensitive enhancement of ET-1 hypotensive effect by chronic NOS inhibition.
Topics: Animals; Blood Pressure; Drug Synergism; Endothelin-1; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Vasodilator Agents | 2003 |
Vascular influences of calcium supplementation and vitamin D-induced hypercalcemia in NaCl-hypertensive rats.
Topics: Animals; Apoptosis; Blood Pressure; Calcium, Dietary; Hypercalcemia; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Rats; Rats, Inbred WKY; Sodium Chloride; Vasodilation; Vitamin D | 2003 |
Apoptosis and NFkappaB activation are simultaneously induced in renal tubulointerstitium in experimental hypertension.
Topics: Angiotensin II; Animals; Apoptosis; Blood Pressure; Enzyme Inhibitors; Hypertension; Kidney; Kidney Tubules; Male; NF-kappa B; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Transcription Factor RelA | 2003 |
Endothelial dysfunction and reduced nitric oxide in resistance arteries in autosomal-dominant polycystic kidney disease.
Topics: Adult; Arginine; Arteries; Endothelium, Vascular; Female; Humans; Hypertension; Kidney Failure, Chronic; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Polycystic Kidney, Autosomal Dominant; Vascular Resistance; Vasodilation | 2003 |
Chronic blockade of nitric oxide does not produce hypertension in baroreceptor denervated rabbits.
Topics: Animals; Blood Pressure; Denervation; Enzyme Inhibitors; Female; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pressoreceptors; Rabbits | 2003 |
The role of hydrogen sulfide generation in the pathogenesis of hypertension in rats induced by inhibition of nitric oxide synthase.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Cystathionine gamma-Lyase; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Heart Rate; Hydrogen Sulfide; Hypertension; Injections, Intraperitoneal; Male; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Sulfides | 2003 |
Supplementation of L-arginine improves hypertension and lipid metabolism but not insulin resistance in diabetic rats.
Topics: Animals; Arginine; Body Weight; Diabetes Mellitus, Type 2; Dietary Supplements; Glucose Clamp Technique; Glucose Tolerance Test; Hypertension; Insulin; Male; Metabolic Syndrome; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred OLETF; Rats, Long-Evans; Triglycerides | 2003 |
Effect of losartan on the blood-brain barrier permeability in diabetic hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blood-Brain Barrier; Diabetes Mellitus, Experimental; Epinephrine; Evans Blue; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Permeability; Rats; Rats, Wistar | 2003 |
Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aspirin; Blood Pressure; Bradykinin; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Epoprostenol; Erythrocyte Aggregation; Hypertension; Indomethacin; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Quinapril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrahydroisoquinolines | 2003 |
Prostacyclin and thromboxane A2 production in nitric oxide-deficient hypertension in vivo. Effects of high calcium diet and angiotensin receptor blockade.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Calcium, Dietary; Enzyme Inhibitors; Epoprostenol; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptors, Angiotensin; Thromboxane A2 | 2003 |
Differential effects of selective cyclooxygenase-2 inhibitors on endothelial function in salt-induced hypertension.
Topics: Acetylcholine; Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Diclofenac; Dinoprost; Endothelium, Vascular; Enzyme Inhibitors; F2-Isoprostanes; Hypertension; Interleukin-1; Isoenzymes; Lactones; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Inbred Dahl; Safety; Sodium Chloride, Dietary; Sulfonamides; Sulfones; Vasodilation | 2003 |
Enalapril attenuates cardiorenal damage in nitric-oxide-deficient spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Cell Count; Enalapril; Hypertension; Kidney Glomerulus; Male; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR | 2004 |
Tempol, an antioxidant, restores endothelium-derived hyperpolarizing factor-mediated vasodilation during hypertension.
Topics: Acetylcholine; Animals; Antioxidants; Benzimidazoles; Biological Factors; Blood Pressure; Calcium Channel Agonists; Cyclic N-Oxides; Cyclooxygenase Inhibitors; Desoxycorticosterone; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radicals; Hypertension; Imidazoles; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Microsomes; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Spin Labels; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2003 |
Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach.
Topics: Animals; Blood Pressure; Body Weight; Chromosomes, Mammalian; Crosses, Genetic; Disease Models, Animal; Female; Genotype; Heart; Hypertension; Kidney; Lod Score; Losartan; Male; Microvascular Angina; Multifactorial Inheritance; NG-Nitroarginine Methyl Ester; Organ Size; Pentolinium Tartrate; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Quantitative Trait Loci; Rats; Rats, Inbred Lew; Rats, Wistar; Sex Factors | 2003 |
Nitric oxide may prevent hypertension early in diabetes by counteracting renal actions of superoxide.
Topics: Animals; Blood Pressure; Cyclic N-Oxides; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glomerular Filtration Rate; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Rats; Rats, Sprague-Dawley; Sodium; Spin Labels; Superoxides | 2004 |
Effect of simvastatin on remodeling of the left ventricle and aorta in L-NAME-induced hypertension.
Topics: Animals; Aorta; Blood Pressure; Body Weight; Coenzymes; DNA; Enzyme Inhibitors; Fibrosis; Hemodynamics; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Rats; Rats, Wistar; Simvastatin; Ubiquinone; Ventricular Remodeling | 2004 |
Kidney adaptation in nitric oxide-deficient Wistar and spontaneously hypertensive rats.
Topics: Algorithms; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Creatinine; Enalapril; Enzyme Inhibitors; Hypertension; Kidney; Kidney Function Tests; Kidney Glomerulus; Kidney Tubules; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Proteinuria; Rats; Rats, Inbred SHR; Rats, Wistar; Renal Circulation | 2004 |
Production and role of extracellular guanosine cyclic 3', 5' monophosphate in sodium uptake in human proximal tubule cells.
Topics: Arginine; Biological Transport; Cells, Cultured; Cyclic GMP; Enzyme Inhibitors; Female; Humans; Hypertension; Ion Transport; Kidney Tubules, Proximal; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Probenecid; S-Nitroso-N-Acetylpenicillamine; Sodium | 2004 |
Rho/Rho-kinase pathway in the brainstem contributes to hypertension caused by chronic nitric oxide synthase inhibition.
Topics: Amides; Animals; Blood Pressure; Enzyme Inhibitors; Hydralazine; Hypertension; Injections; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred WKY; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Solitary Nucleus | 2004 |
Functional study of the [Ca2+]i signaling pathway in aortas of L-NAME-hypertensive rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Administration, Oral; Animals; Aorta, Thoracic; Caffeine; Calcium; Calcium Signaling; Disease Models, Animal; Drug Synergism; Endothelium, Vascular; Hypertension; Indomethacin; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Phenylephrine; Phorbol 12,13-Dibutyrate; Phorbol Esters; Prostaglandins; Protein Kinase C; Rats; Rats, Wistar; Time Factors; Tunica Intima; Vasoconstriction | 2004 |
Alteration in endothelin receptor sub-type responsiveness and in the endothelin-TXA(2) mimetic U46619 interaction, in type-2 hypertensive diabetic Zucker rats.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetylcholine; Animals; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Diabetes Mellitus, Type 2; Drug Interactions; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Hypertension; Kidney Cortex; Kidney Medulla; Male; NG-Nitroarginine Methyl Ester; Oligopeptides; Piperidines; Platelet Aggregation; Rats; Rats, Sprague-Dawley; Rats, Zucker; Receptor Cross-Talk; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Thromboxane A2 | 2004 |
Anti-lipid deposition effect of HMG-CoA reductase inhibitor, pitavastatin, in a rat model of hypertension and hypercholesterolemia.
Topics: Animals; Aorta; Arteriosclerosis; Cholesterol; Dietary Fats; Disease Models, Animal; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperlipidemias; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Quinolines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley | 2004 |
Effects of chloride substitution on electromechanical responses in the pulmonary artery of Dahl normotensive and hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Chlorides; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; Imidazoles; Membrane Potentials; Methacholine Chloride; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Propionates; Pulmonary Artery; Rats; Rats, Inbred Dahl; Receptors, Adrenergic, alpha; Sodium Chloride; Vasoconstriction | 2004 |
Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G.
Topics: Adrenalectomy; Animals; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Denervation; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Guanylate Cyclase; Hypertension; Ion Transport; Kidney; Kidney Cortex; Kidney Medulla; Kidney Tubules, Proximal; Natriuresis; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cytoplasmic and Nuclear; Signal Transduction; Sodium; Soluble Guanylyl Cyclase; Thionucleotides | 2004 |
Nitric oxide release in the nucleus tractus solitarius during and after bilateral common carotid artery occlusion.
Topics: Animals; Arterial Occlusive Diseases; Blood Pressure; Carotid Artery Diseases; Carotid Artery, Common; Cats; Dizocilpine Maleate; Female; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Receptors, N-Methyl-D-Aspartate; Solitary Nucleus; Time Factors | 2004 |
Prevention of renal vascular and glomerular fibrosis by epidermal growth factor receptor inhibition.
Topics: Animals; Capillaries; Collagen; Collagen Type I; Creatinine; Endothelin-1; ErbB Receptors; Fibrosis; Gefitinib; Gene Expression Regulation; Genes, Reporter; Glomerulosclerosis, Focal Segmental; Hypertension; Ischemia; Kidney; Kidney Cortex; Kidney Diseases; Kidney Glomerulus; Male; MAP Kinase Signaling System; Mice; Mice, Transgenic; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphorylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proteinuria; Quinazolines; Rats; Rats, Sprague-Dawley | 2004 |
Effects of bulbus Fritillaria water extract on blood pressure and renal functions in the L-NAME-induced hypertensive rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Fritillaria; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Phytotherapy; Plant Extracts; Rats; Rats, Sprague-Dawley | 2004 |
Nitric oxide inhibition accelerates hypertension and induces perivascular inflammation in rats.
Topics: Animals; Arterioles; Arteritis; Carotid Artery, Internal; Hypertension; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2004 |
Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Bone Marrow Transplantation; Chemokine CCL2; Chemotaxis, Leukocyte; Enzyme Inhibitors; Humans; Hypertension; Hypertrophy, Left Ventricular; Imidazoles; Inflammation; Infusion Pumps, Implantable; Male; Mice; Mice, Inbred C57BL; Monocytes; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Olmesartan Medoxomil; Pilot Projects; Radiation Chimera; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptors, CCR2; Receptors, Chemokine; Recombinant Fusion Proteins; Superoxide Dismutase; Tetrazoles; Up-Regulation | 2004 |
Effects of chronic nitric oxide synthase inhibition on cerebral arterioles in Wistar-Kyoto rats.
Topics: Animals; Arterioles; Blood Pressure; Body Weight; Cerebral Arteries; Cerebrovascular Circulation; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2004 |
Excessive zinc intake elevates systemic blood pressure levels in normotensive rats--potential role of superoxide-induced oxidative stress.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Chromium; Copper; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Rats; Rats, Sprague-Dawley; RNA, Messenger; Superoxide Dismutase; Superoxides; Zinc | 2004 |
Cardiac hypertrophy and fibrosis in chronic L-NAME-treated AT2 receptor-deficient mice.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Fibrosis; Heart Rate; Hypertension; Hypertrophy, Left Ventricular; Male; Mice; Mice, Mutant Strains; NG-Nitroarginine Methyl Ester; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; RNA, Messenger; Ventricular Function, Left | 2004 |
Vasoactive systems in L-NAME hypertension: the role of inducible nitric oxide synthase.
Topics: Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanidines; Heart Ventricles; Hypertension; Injections, Intravenous; Male; Models, Cardiovascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Renin-Angiotensin System; Time Factors; Vasoconstriction; Vasodilator Agents | 2004 |
Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.
Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Blood Pressure; Colforsin; Disease Models, Animal; Enzyme Inhibitors; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension; Losartan; Male; Models, Cardiovascular; NG-Nitroarginine Methyl Ester; Proto-Oncogene Proteins; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; RNA, Messenger; Sodium Fluoride; Statistics as Topic | 2004 |
Role of sex, gonadectomy and sex hormones in the development of nitric oxide inhibition-induced hypertension.
Topics: Animals; Blood Pressure; Body Weight; Castration; Enzyme Inhibitors; Estrogens; Female; Gonadal Steroid Hormones; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Proteinuria; Rats; Rats, Wistar; Renin; Sex Characteristics; Testosterone | 2004 |
Interactions between nitric oxide and superoxide on the neural regulation of proximal fluid reabsorption in hypertensive rats.
Topics: Adrenergic Fibers; Animals; Electric Stimulation; Glomerular Filtration Rate; Hypertension; Kidney Tubules, Proximal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Wistar; Superoxides | 2004 |
AKT participates in endothelial dysfunction in hypertension.
Topics: Acetylcholine; Adenoviridae; Animals; Aorta; Carotid Artery, Common; Cell Membrane; Cells, Cultured; Endothelial Cells; Endothelium, Vascular; Genetic Vectors; Humans; Hypertension; Injections, Intra-Arterial; Insulin; Isoproterenol; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Ultrasonography; Vasodilation; Vasodilator Agents | 2004 |
Is there a link between salt-intake and atrial natriuretic peptide system during hypertension induced by nitric oxide blockade?
Topics: Animals; Atrial Natriuretic Factor; Blood Pressure; Blotting, Northern; Enzyme Inhibitors; Heart Atria; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; RNA, Messenger; Sodium Chloride, Dietary | 2004 |
Aldosterone modulates neural vasomotor response in hypertension: role of calcitonin gene-related peptide.
Topics: Adenine; Adenosine Triphosphate; Aldosterone; Animals; Anti-Arrhythmia Agents; Calcitonin Gene-Related Peptide; Capsaicin; Cyclic GMP; Electric Stimulation; Enzyme Inhibitors; Glyburide; Hypertension; Male; Mesenteric Arteries; Mineralocorticoid Receptor Antagonists; Neurons; NG-Nitroarginine Methyl Ester; Norepinephrine; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Glucocorticoid; Spironolactone; Vasoconstriction; Vasomotor System | 2004 |
Modulation of neurotransmitter release by NO is altered in mesenteric arterial bed of spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Enzyme Inhibitors; Hypertension; Male; Neuropeptide Y; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Splanchnic Circulation; Synaptic Transmission; Yohimbine | 2004 |
Structural changes in cerebral arteries following nitric oxide deprivation: a comparison between normotensive and hypertensive rats.
Topics: Animals; Cell Size; Cerebral Arteries; Enzyme Inhibitors; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2004 |
Physical conditioning modulates rat cardiac vascular endothelial growth factor gene expression in nitric oxide-deficient hypertension.
Topics: Animals; Blood Pressure; Gene Expression Regulation; Heart; Homeostasis; Hypertension; Male; Malondialdehyde; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Vascular Endothelial Growth Factor A | 2004 |
Red wine polyphenols prevent cardiovascular alterations in L-NAME-induced hypertension.
Topics: Alkadienes; Animals; Aortic Diseases; Blood Pressure; Blotting, Western; Carbon Radioisotopes; Enzyme Inhibitors; Flavonoids; Hypertension; Hypertrophy, Left Ventricular; Leucine; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Phenols; Polyphenols; Rats; Rats, Wistar; Vasoconstrictor Agents; Wine | 2004 |
Ouabain-induced hypertension alters the participation of endothelial factors in alpha-adrenergic responses differently in rat resistance and conductance mesenteric arteries.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Cardiotonic Agents; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Losartan; Male; Mesenteric Arteries; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Norepinephrine; Ouabain; Phenylephrine; Potassium Chloride; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Adrenergic, alpha; Vascular Resistance; Vasoconstrictor Agents | 2004 |
Systemic hemodynamics in non-anesthetized L-NAME- and DOCA-salt-treated mice.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Desoxycorticosterone; Drug Synergism; Enzyme Inhibitors; Hemodynamics; Hypertension; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Sodium Chloride; Tetrazoles; Time Factors; Valine; Valsartan; Vascular Resistance | 2004 |
Effects of boiling on the antihypertensive and antioxidant activities of onion.
Topics: Animals; Antihypertensive Agents; Antioxidants; Eating; Food Handling; Hot Temperature; Hypertension; Liver; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Onions; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Thiobarbituric Acid Reactive Substances; Weight Gain | 2004 |
Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase.
Topics: Animals; Arterioles; Blood Pressure; Brain; Carotid Artery, Common; Edetic Acid; Endothelium, Vascular; Female; Genotype; Hypertension; Hypertrophy; Ligation; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Species Specificity; Vasodilation | 2004 |
N-acetylcysteine treatment normalizes serum tumor necrosis factor-alpha level and hinders the progression of cardiac injury in hypertensive rats.
Topics: Acetylcysteine; Animals; Antioxidants; Collagen; Disease Progression; Drug Evaluation, Preclinical; Glutathione; Heart Ventricles; Hypertension; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Wistar; Sodium Chloride, Dietary; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha; Ultrasonography; Ventricular Dysfunction, Left; Ventricular Remodeling | 2004 |
Apurinic/apyrimidinic endonuclease 1 regulates endothelial NO production and vascular tone.
Topics: Animals; Aorta; Blood Pressure; Calcium; Cattle; Cells, Cultured; DNA-(Apurinic or Apyrimidinic Site) Lyase; Endothelial Cells; Endothelium, Vascular; Genes, ras; Humans; Hypertension; Male; Mice; Mice, Knockout; Mutagenesis, Site-Directed; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidation-Reduction; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins p21(ras); Rats; Transfection; Umbilical Veins; Vascular Resistance; Vasoconstriction | 2004 |
Mechanism of the endothelium-dependent vasodilation and the antihypertensive effect of Brazilian red wine.
Topics: Acetylcholine; Administration, Oral; Alcohol Drinking; Animals; Apamin; Atropine; Blood Pressure; Bradykinin; Brazil; Charybdotoxin; Clonidine; Deoxycholic Acid; Drug Therapy, Combination; Endothelium, Vascular; Flavonoids; Glyburide; Guanylate Cyclase; Hypertension; Indomethacin; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroglycerin; Norepinephrine; Oxadiazoles; Perfusion; Phenols; Polyphenols; Potassium Chloride; Pressure; Pyrilamine; Quinazolines; Quinoxalines; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Wine; Yohimbine | 2004 |
Impairment of smooth muscle function of rat thoracic aorta in an endothelium-independent manner by long-term administration of N(G)-nitro-L-arginine methyl ester.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Blood Pressure; Calcium; Calcium Radioisotopes; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilator Agents | 2004 |
Captopril reverses the reduced vasodilator response to bradykinin in hypertensive pregnant rats.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Biological Factors; Bradykinin; Captopril; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hypertension; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Pregnancy; Pregnancy Complications, Cardiovascular; Rats; Rats, Inbred SHR; Rats, Wistar; Splanchnic Circulation; Vasodilation; Vasodilator Agents | 2004 |
Rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Brain; Endothelium, Vascular; Heart Ventricles; Hypertension; Imidazoline Receptors; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxazoles; Rats; Rats, Wistar; Receptors, Drug; Rilmenidine | 2004 |
Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress.
Topics: Acridines; Animals; Antihypertensive Agents; Blood Pressure; Cyclic N-Oxides; Dinoprost; Enzyme Inhibitors; Hypertension; Luminescent Measurements; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Oxidative Stress; Rats; Rats, Inbred SHR; Renin; Renin-Angiotensin System; Spin Labels; Superoxides | 2005 |
Nitrite is an alternative source of NO in vivo.
Topics: Administration, Oral; Animals; Blood Pressure; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Glycated Hemoglobin; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrites; Nitrogen Isotopes; Rats; Rats, Sprague-Dawley | 2005 |
Different involvement of extracellular matrix components in small and large arteries during chronic NO synthase inhibition.
Topics: Animals; Aorta; Arteries; Blotting, Western; Doxycycline; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Extracellular Matrix; Hypertension; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Tenascin; Thrombospondins | 2005 |
Vascular responses to IGF-I and insulin are impaired in aortae of hypertensive rats.
Topics: Androstadienes; Animals; Aorta, Thoracic; Chromones; Endothelin-1; Enzyme Inhibitors; Female; Hypertension; Insulin; Insulin-Like Growth Factor I; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenylephrine; Phosphoinositide-3 Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Wortmannin | 2005 |
Central neuropeptide Y signaling ameliorates N(omega)-nitro-L-arginine methyl ester hypertension in the rat through a Y1 receptor mechanism.
Topics: Animals; Animals, Genetically Modified; Blood Pressure; Central Nervous System; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart; Heart Rate; Hypertension; Male; Neuropeptide Y; NG-Nitroarginine Methyl Ester; Proteinuria; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Receptors, Neuropeptide; Signal Transduction; Up-Regulation | 2005 |
Elevated endothelial nitric oxide bioactivity and resistance to angiotensin-dependent hypertension in 12/15-lipoxygenase knockout mice.
Topics: Acetylcholine; Angiotensins; Animals; Aorta; Arachidonate 12-Lipoxygenase; Arachidonate 15-Lipoxygenase; Blood Pressure; Body Weight; Dose-Response Relationship, Drug; Down-Regulation; Hypertension; Immunohistochemistry; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Signal Transduction; Time Factors | 2005 |
Effects of lipopolysaccharide on the blood-brain barrier permeability in prolonged nitric oxide blockade-induced hypertensive rats.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Astrocytes; Blood-Brain Barrier; Capillary Permeability; Cerebellum; Coloring Agents; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Evans Blue; Extravasation of Diagnostic and Therapeutic Materials; Hypertension; Interleukin-1; Interleukin-6; Lipopolysaccharides; Male; Membrane Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphoproteins; Rats; Rats, Wistar; Tumor Necrosis Factor-alpha; Zonula Occludens-1 Protein | 2005 |
Hypertensive target organ damage is attenuated by a p38 MAPK inhibitor: role of systemic blood pressure and endothelial protection.
Topics: Animals; Echocardiography; Hypertension; Imidazoles; In Vitro Techniques; Kidney; Male; Models, Animal; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; p38 Mitogen-Activated Protein Kinases; Pyrimidines; Rats; Rats, Inbred SHR; Vascular Resistance | 2005 |
Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats.
Topics: Animals; Aorta; Arginase; Blood Pressure; Eflornithine; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ornithine Decarboxylase; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2005 |
Effects of atorvastatin on blood-brain barrier permeability during L-NAME hypertension followed by angiotensin-II in rats.
Topics: Angiotensin II; Animals; Atorvastatin; Blood-Brain Barrier; Heptanoic Acids; Hypertension; Male; NG-Nitroarginine Methyl Ester; Permeability; Pyrroles; Rats; Rats, Wistar | 2005 |
Oxytalan elastic and collagen fibers during the repair process in experimental nitric oxide inhibition.
Topics: Animals; Collagen; Enzyme Inhibitors; Extracellular Matrix Proteins; Fibrosis; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Rats; Rats, Wistar | 2005 |
Impact of nitric oxide synthase inhibitor and chloride channel antagonist on mesenteric vascular conductance in anesthetized Dahl normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Chloride Channels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hypertension; Imidazoles; In Vitro Techniques; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred Dahl; Vasoconstriction | 2005 |
Spontaneous stroke in a genetic model of hypertension in mice.
Topics: Angiotensinogen; Animal Feed; Animals; Blood Pressure; Brain; Circadian Rhythm; Disease Models, Animal; Female; Humans; Hypertension; Intracranial Hemorrhages; Mice; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Renin; Salts; Stroke | 2005 |
Increased superoxide production in hypertensive patients with diabetes mellitus: role of nitric oxide synthase.
Topics: Adult; Aged; Biomarkers; Biphenyl Compounds; Blood Platelets; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Female; Follow-Up Studies; Humans; Hypertension; In Vitro Techniques; Luminescent Measurements; Male; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Onium Compounds; Oxidative Stress; Quinacrine; Superoxides | 2005 |
Antioxidant enzymes and effects of tempol on the development of hypertension induced by nitric oxide inhibition.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Antioxidants; Biomarkers; Blood Pressure; Catalase; Cyclic N-Oxides; Deoxyguanosine; Disease Models, Animal; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Glutathione Peroxidase; Glutathione Reductase; Heart Rate; Heart Ventricles; Hypertension; Kidney Cortex; Kidney Medulla; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Oxidoreductases; Rats; Rats, Wistar; Spectrophotometry; Spin Labels; Superoxide Dismutase | 2005 |
L-arginine fails to protect against myocardial remodelling in L-NAME-induced hypertension.
Topics: Animals; Antihypertensive Agents; Arginine; Brain; Hydroxyproline; Hypertension; Hypertrophy, Left Ventricular; Kidney; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Ubiquinone | 2005 |
Angiotensin-converting enzyme inhibition and angiotensin AT1-receptor antagonism equally improve endothelial vasodilator function in L-NAME-induced hypertensive rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Enalapril; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Norepinephrine; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Systole; Vasoconstriction; Vasodilation; Vasodilator Agents | 2005 |
Effects of chloride substitution in isolated mesenteric blood vessels from Dahl normotensive and hypertensive rats.
Topics: Animals; Chlorides; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Hypertension; Imidazoles; In Vitro Techniques; Isotonic Solutions; Membrane Potentials; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Niflumic Acid; Nitrates; Nitric Oxide Synthase; Nitrites; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Vasoconstriction; Vasoconstrictor Agents | 2005 |
Renal damage susceptibility and autoregulation in RF-1 and RF-5 congenic rats.
Topics: Albuminuria; Animals; Animals, Congenic; Blood Pressure; Chimera; Enzyme Inhibitors; Genetic Predisposition to Disease; Glomerulosclerosis, Focal Segmental; Homeostasis; Hypertension; Kidney Diseases; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Proteinuria; Quantitative Trait Loci; Rats; Rats, Inbred ACI; Rats, Inbred Strains; Renal Circulation | 2005 |
Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Body Weight; Creatinine; Dose-Response Relationship, Drug; Heart; Hypertension; Kidney; Lipid Peroxidation; Losartan; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Organ Size; Oxidative Stress; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Time Factors | 2004 |
Blood pressure variability, cardiac baroreflex sensitivity and organ damage in experimentally hypertensive rats.
Topics: Angiotensin II; Animals; Baroreflex; Blood Pressure; Blood Pressure Determination; Desoxycorticosterone; Disease Models, Animal; Endothelin-1; Hypertension; Hypertension, Renovascular; Interleukin-1; Kidney Glomerulus; Male; Myocardium; NG-Nitroarginine Methyl Ester; Organ Size; Rats; Rats, Sprague-Dawley; Time Factors; Tumor Necrosis Factor-alpha | 2005 |
Signal transduction involving Ras-GTPase contributes to development of hypertension and end-organ damage in spontaneously hypertensive rats-treated with L-NAME.
Topics: Animals; Blood Pressure; Collagen Type III; Hypertension; Isoproterenol; Kidney; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Organophosphonates; ras Proteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Signal Transduction; Sodium-Hydrogen Exchangers; Ventricular Function, Left | 2005 |
Ultrastructure and histochemistry of rat myocardial capillary endothelial cells in response to diabetes and hypertension.
Topics: Animals; Capillaries; Diabetes Complications; Diabetes Mellitus; Disease Models, Animal; Endothelial Cells; Heart Failure; Hypertension; Immunohistochemistry; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Streptozocin | 2005 |
Physical training increases renal injury in rats with chronic NOS inhibition.
Topics: Adaptation, Physiological; Animals; Body Weight; Disease Models, Animal; Hemodynamics; Hypertension; Hypertension, Renal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Physical Conditioning, Animal; Probability; Random Allocation; Rats; Rats, Wistar; Reference Values; Sensitivity and Specificity | 2005 |
Superoxide contributes to development of salt sensitivity and hypertension induced by nitric oxide deficiency.
Topics: Animals; Blood Pressure; Cyclic N-Oxides; Dinoprost; Diuresis; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Hydrogen Peroxide; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary; Spin Labels; Superoxides | 2005 |
A selective estrogen receptor modulator, tamoxifen, and membrane fluidity of erythrocytes in normotensive and hypertensive postmenopausal women: an electron paramagnetic resonance investigation.
Topics: Aged; Analysis of Variance; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Drug Synergism; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Erythrocyte Membrane; Erythrocytes; Estradiol; Estrogen Antagonists; Female; Fulvestrant; Humans; Hypertension; Membrane Fluidity; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Postmenopause; S-Nitroso-N-Acetylpenicillamine; Selective Estrogen Receptor Modulators; Tamoxifen | 2005 |
Investigation of local ACE activity and structural alterations during development of L-NAME-induced hypertension.
Topics: Animals; Blood Pressure; Hypertension; NG-Nitroarginine Methyl Ester; Organ Size; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley | 2005 |
Chronic N-acetylcysteine administration prevents development of hypertension in N(omega)-nitro-L-arginine methyl ester-treated rats: the role of reactive oxygen species.
Topics: Acetylcysteine; Animals; Antioxidants; Aorta; Cyclic N-Oxides; Drug Interactions; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Reactive Oxygen Species; Spin Labels | 2005 |
Effect of pioglitazone on L-NAME induced hypertension in diabetic rats.
Topics: Animals; Aorta, Thoracic; Blood Glucose; Blood Pressure; Body Weight; Catalase; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glutathione; Hypertension; Hypoglycemic Agents; In Vitro Techniques; Lipid Peroxidation; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Oxidation-Reduction; Pioglitazone; Rats; Rats, Sprague-Dawley; Superoxide Dismutase; Thiazolidinediones; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Contribution of cytochrome P450 metabolites of arachidonic acid to hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
Topics: Animals; Arachidonic Acid; Blood Pressure; Blood Vessels; Collagen Type III; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Isoproterenol; Kidney; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Proteinuria; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Splanchnic Circulation; Triazoles; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
A novel mechanism prevents the development of hypertension during chronic cold stress.
Topics: Animals; Blood Pressure; Cold Temperature; Electric Stimulation; Hypertension; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Norepinephrine; Perfusion; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stress, Physiological; Superior Cervical Ganglion; Sympathetic Nervous System; Tyrosine 3-Monooxygenase | 2005 |
Effects of angiotensin-converting-enzyme inhibitors in combination with diuretics on blood pressure and renal injury in nitric oxide-deficiency-induced hypertension in rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Diuretics; Drug Therapy, Combination; Enalapril; Hydrochlorothiazide; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tyrosine | 2006 |
Exaggerated liver injury induced by ischemia-reperfusion in spontaneously hypertensive rats.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Biomarkers; Blood Pressure; Desoxycorticosterone; Enzyme Inhibitors; Heart Rate; Hypertension; Liver; Liver Diseases; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peroxidase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Reperfusion Injury; Tumor Necrosis Factor-alpha | 2005 |
Dose-dependent autonomic dysfunction in chronic L-NAME-hypertensive diabetic rats.
Topics: Animals; Autonomic Nervous System Diseases; Baroreflex; Blood Pressure; Chronic Disease; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar | 2005 |
Insulin improves the endothelium-independent relaxation and the contractile response in aorta from hypertensive diabetic rats.
Topics: Animals; Aorta, Thoracic; Diabetes Mellitus, Experimental; Endothelium, Vascular; Hypertension; In Vitro Techniques; Insulin; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Potassium Chloride; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation | 2005 |
Differential expression of components of the cardiomyocyte adrenomedullin/intermedin receptor system following blood pressure reduction in nitric oxide-deficient hypertension.
Topics: Adrenomedullin; Animals; Body Weight; Hydralazine; Hydrochlorothiazide; Hypertension; Intracellular Signaling Peptides and Proteins; Male; Membrane Proteins; Myocytes, Cardiac; Myosin Heavy Chains; Neuropeptides; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Peptides; Rats; Rats, Sprague-Dawley; Receptor Activity-Modifying Protein 1; Receptor Activity-Modifying Protein 2; Receptor Activity-Modifying Protein 3; Receptor Activity-Modifying Proteins; Receptors, Adrenomedullin; Receptors, Peptide; RNA, Messenger; Systole | 2006 |
L-NAME hypertension: trying to fit the pieces together.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cardiovascular System; Enzyme Inhibitors; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prostaglandins; Rats; Renin-Angiotensin System; Superoxides; Sympathetic Nervous System | 2006 |
Angiotensin II type 1 receptor antagonism improves endothelial vasodilator function in L-NAME-induced hypertensive rats by a kinin-dependent mechanism.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bradykinin; Bradykinin B2 Receptor Antagonists; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Hypertension; Kinins; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Nitroprusside; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Bradykinin B2; RNA, Messenger; Vasodilation | 2006 |
Calcium channel blockades exhibit anti-inflammatory and antioxidative effects by augmentation of endothelial nitric oxide synthase and the inhibition of angiotensin converting enzyme in the N(G)-nitro-L-arginine methyl ester-induced hypertensive rat aorta
Topics: Amlodipine; Angiotensin-Converting Enzyme Inhibitors; Animals; Anti-Inflammatory Agents; Antihypertensive Agents; Antioxidants; Aorta; Blood Pressure; Body Weight; Calcium Channel Blockers; Chemokine CCL2; Dihydropyridines; Enzyme Inhibitors; Gene Expression Regulation; Heart Rate; Hypertension; Inflammation; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitrobenzenes; Oxidative Stress; Peptidyl-Dipeptidase A; Piperazines; Polymerase Chain Reaction; Rats; Rats, Wistar; RNA, Messenger; Vascular Cell Adhesion Molecule-1 | 2005 |
Crataegus tanacetifolia leaf extract prevents L-NAME-induced hypertension in rats: a morphological study.
Topics: Animals; Blood Pressure; Coronary Vessels; Crataegus; Enzyme Inhibitors; Hypertension; Kidney; Lipids; Male; Myocardium; Myocytes, Smooth Muscle; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Plant Extracts; Plant Leaves; Quercetin; Rats | 2006 |
Enhanced superoxide activity modulates renal function in NO-deficient hypertensive rats.
Topics: Animals; Antioxidants; Cyclic N-Oxides; Dinoprost; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Hypertension; Injections, Intra-Arterial; Kidney; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Sprague-Dawley; Renal Artery; Renal Circulation; Spin Labels; Superoxides; Vascular Resistance | 2006 |
Angiotensin-(1-7) prevents development of severe hypertension and end-organ damage in spontaneously hypertensive rats treated with L-NAME.
Topics: Angiotensin I; Animals; Antihypertensive Agents; Blood Pressure; Diuresis; Enzyme Inhibitors; Heart; Hypertension; Kidney; Male; Myocardial Ischemia; Myocardium; NG-Nitroarginine Methyl Ester; Peptide Fragments; Proteinuria; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Recovery of Function; Reperfusion Injury; Severity of Illness Index; Vasomotor System | 2006 |
Does central nitric oxide elicit pulmonary hypertension in conscious rats?
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Blood Pressure; Enzyme Inhibitors; Heart Rate; Hypertension; Hypoxia; Infusion Pumps, Implantable; Injections, Intraventricular; Isoproterenol; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Telemetry; Time Factors; Wakefulness | 2006 |
[Peculiarities of NO-syntase expression in experimental hypertension caused by inhibition during low frequency laser irradiation of cardiovascular system and kidneys].
Topics: Animals; Cardiovascular System; Hypertension; Kidney; Low-Level Light Therapy; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats | 2005 |
Renal thrombotic microangiopathy in a genetic model of hypertension in mice.
Topics: Angiotensins; Animals; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Humans; Hypertension; Kidney; Kidney Glomerulus; Mice; Mice, Transgenic; Microcirculation; NG-Nitroarginine Methyl Ester; Renal Circulation; Renin; Sodium, Dietary | 2006 |
Reduced expression of endothelial connexins 43 and 37 in hypertensive rats is rectified after 7-day carvedilol treatment.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Atenolol; Biomarkers; Blood Pressure; Blotting, Northern; Blotting, Western; Carbazoles; Carvedilol; Cells, Cultured; Connexin 43; Connexins; Disease Models, Animal; Endothelial Cells; Endothelium, Vascular; Follow-Up Studies; Gap Junction alpha-4 Protein; Humans; Hypertension; Immunohistochemistry; In Vitro Techniques; Microscopy, Confocal; NG-Nitroarginine Methyl Ester; Propanolamines; Rats; Rats, Sprague-Dawley; Time Factors; Treatment Outcome; Umbilical Veins | 2006 |
Progression of severe atherosclerosis and increased arterial pulse pressure in the newly developed heritable mixed hyperlipidaemic rabbits.
Topics: Aging; Animals; Aorta; Atherosclerosis; Blood Pressure; Body Weight; Cholesterol; Disease Progression; Electrocardiography; Enzyme Inhibitors; Hyperlipoproteinemia Type V; Hypertension; Lipids; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rabbits; Triglycerides | 2006 |
Endothelium-dependent inhibition of the contractile response is decreased in aorta from aged and spontaneously hypertensive rats.
Topics: Aging; Animals; Aorta; Disease Models, Animal; Endothelium; Hypertension; Indomethacin; Male; Muscle Contraction; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Serotonin | 2006 |
[Some markers of oxidative stress in hypertension induced by chronic inhibition of nitric oxide synthase].
Topics: Adrenal Cortex; Aldehydes; Animals; Antioxidants; Biomarkers; Enzyme Inhibitors; Hypertension; Lipid Peroxidation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Rats; Rats, Wistar | 2005 |
Triterpenic compounds from "orujo" olive oil elicit vasorelaxation in aorta from spontaneously hypertensive rats.
Topics: Animals; Aorta; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Olive Oil; Plant Oils; Rats; Rats, Inbred SHR; Triterpenes | 2006 |
Exposure to stress differential vascular adaptive response in spontaneously hypertensive and Wistar rats: Role of nitric oxide, and prehypertensive and hypertensive states.
Topics: Adaptation, Physiological; Adrenergic alpha-Agonists; Animals; Aorta; Endothelium, Vascular; Hemodynamics; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Wistar; Stress, Psychological | 2006 |
Impairment on cardiac output and blood flow adjustments to exercise in L-NAME-induced hypertensive rats.
Topics: Animals; Cardiac Output; Hypertension; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxygen; Oxygen Consumption; Physical Conditioning, Animal; Rats; Rats, Wistar; Regional Blood Flow; Renal Circulation; Vascular Resistance | 2006 |
Protective effects of BAY 41-2272 (sGC stimulator) on hypertension, heart, and cardiomyocyte hypertrophy induced by chronic L-NAME treatment in rats.
Topics: Animals; Blood Pressure; Body Weight; Cardiomegaly; Fibrosis; Guanylate Cyclase; Heart Rate; Hypertension; Male; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyrazoles; Pyridines; Rats; Rats, Wistar | 2006 |
Adiponectin replenishment ameliorates obesity-related hypertension.
Topics: Adenoviridae; Adiponectin; Animals; Aorta; Blood Pressure; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Transfer Techniques; Genetic Vectors; Hypertension; Insulin Resistance; Intramolecular Oxidoreductases; Male; Mice; Mice, Inbred Strains; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Obesity; RNA, Messenger; Sodium Chloride, Dietary | 2006 |
Macrophage populations and cardiac sympathetic denervation during L-NAME-induced hypertension in rats.
Topics: Animals; Drug Therapy, Combination; Enzyme Inhibitors; Guanidines; Heart; Hemodynamics; Hypertension; Macrophages; Male; Myocytes, Cardiac; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitrites; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical; Sympathetic Nervous System | 2006 |
The vasodilator potency of the endothelium-derived relaxing factor, L-S-nitrosocysteine, is impaired in conscious spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Blood Pressure; Coenzyme A; Cysteine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Femoral Artery; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; S-Nitrosothiols; Splanchnic Circulation; Vascular Resistance; Vasodilation; Vasodilator Agents | 2006 |
Enhanced expression of serum and glucocorticoid-inducible kinase-1 in kidneys of L-NAME-treated rats.
Topics: Albuminuria; Animals; Blood Pressure; Creatinine; Hypertension; Immediate-Early Proteins; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Protein Serine-Threonine Kinases; Rats; Rats, Sprague-Dawley; RNA, Messenger | 2006 |
MgSO4 prevents left ventricular dysfunction in an animal model of preeclampsia.
Topics: Animals; Cardiac Output; Disease Models, Animal; Enzyme Inhibitors; Female; Heart; Hypertension; Magnesium Sulfate; NG-Nitroarginine Methyl Ester; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley; Ventricular Dysfunction, Left | 2006 |
Role of T lymphocytes in hypertension-induced cardiac extracellular matrix remodeling.
Topics: Amino Acid Oxidoreductases; Animals; Collagen; Disease Models, Animal; Extracellular Matrix; Female; Gene Expression; Hypertension; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; NG-Nitroarginine Methyl Ester; Species Specificity; T-Lymphocytes; Ventricular Function, Left; Ventricular Remodeling | 2006 |
Impact of T lymphocytes on cardiac remodeling in hypertension: more questions than answers.
Topics: Animals; Hypertension; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, SCID; NG-Nitroarginine Methyl Ester; Species Specificity; T-Lymphocytes; Ventricular Function, Left; Ventricular Remodeling | 2006 |
The antagonism of aldosterone receptor prevents the development of hypertensive heart failure induced by chronic inhibition of nitric oxide synthesis in rats.
Topics: Actins; Aldosterone; Animals; Blotting, Western; Cytochrome P-450 CYP11B2; Drug Therapy, Combination; Eplerenone; Fibrosis; Heart Failure; Heart Ventricles; Hypertension; Immunohistochemistry; Male; Mineralocorticoid Receptor Antagonists; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Proliferating Cell Nuclear Antigen; Protein Precursors; Random Allocation; Rats; Rats, Inbred WKY; Receptors, Mineralocorticoid; RNA, Messenger; Spironolactone; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2006 |
Angiotensin II type 1 receptor blocker prevents atrial structural remodeling in rats with hypertension induced by chronic nitric oxide inhibition.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Enzyme Inhibitors; Heart Atria; Heart Rate; Hydralazine; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Tetrazoles; Thrombomodulin | 2006 |
Sildenafil reduces cardiovascular remodeling associated with hypertensive cardiomyopathy in NOS inhibitor-treated rats.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Blood Pressure; Cardiomyopathies; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Enzyme Inhibitors; Heart; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones | 2006 |
Antihypertensive responses elicited by central moxonidine in rats: possible role of nitric oxide.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Bradycardia; Drug Interactions; Endothelium-Dependent Relaxing Factors; Excitatory Amino Acid Antagonists; Heart Rate; Hypertension; Hypotension; Imidazoles; Kynurenic Acid; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sympathetic Nervous System; Vascular Resistance; Vasodilation | 2006 |
Ghrelin inhibits vascular superoxide production in spontaneously hypertensive rats.
Topics: Animals; Aorta; Ghrelin; Hypertension; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Hormones; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Superoxides | 2006 |
Loss of alpha2B-adrenoceptors increases magnitude of hypertension following nitric oxide synthase inhibition.
Topics: Adrenergic alpha-Agonists; Animals; Dose-Response Relationship, Drug; Gene Deletion; Heterozygote; Hypertension; Mesenteric Arteries; Mice; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenylephrine; Receptors, Adrenergic, alpha-2; Telemetry | 2006 |
Effects of angiotensin II type 1 receptor blockade on the systemic blood nitric oxide dynamics in Nomega-nitro-L-arginine methyl ester-treated rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Electron Spin Resonance Spectroscopy; Endothelium, Vascular; Heart Rate; Hemodynamics; Hemoglobins; Hydralazine; Hypertension; Imidazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Tetrazoles | 2006 |
Absence of an interaction between the Rf-1 and Rf-5 QTLs influencing susceptibility to renal damage in rats.
Topics: Albuminuria; Animals; Animals, Congenic; Blood Pressure; Enzyme Inhibitors; Epistasis, Genetic; Genetic Predisposition to Disease; Glomerulosclerosis, Focal Segmental; Homeostasis; Hypertension; Nephrectomy; NG-Nitroarginine Methyl Ester; Quantitative Trait Loci; Rats; Rats, Inbred Strains; Renal Circulation; Renal Insufficiency; Survival Analysis | 2006 |
Nitric oxide signaling in stretch-induced apoptosis of neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Apoptosis; Cell Death; Enzyme Induction; Guanylate Cyclase; Heart; Hypertension; Muscle Cells; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Reflex, Stretch; Signal Transduction | 2006 |
Renal effects of HMG-CoA reductase inhibition in a rat model of chronic inhibition of nitric oxide synthesis.
Topics: Albuminuria; Analysis of Variance; Animals; Atorvastatin; Blood Pressure; Caveolin 1; Glomerular Filtration Rate; Heptanoic Acids; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Kidney Diseases; Kidney Glomerulus; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyrroles; Rats; Rats, Wistar; rhoA GTP-Binding Protein; Vascular Endothelial Growth Factor A | 2006 |
Nitric oxide synthase inhibition in rats: melatonin reduces blood pressure and ischemia/reperfusion-induced infarct size.
Topics: Animals; Antioxidants; Blood Pressure; Hypertension; Male; Melatonin; Models, Animal; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar | 2006 |
Mechanisms underlying biochanin A-induced relaxation of the aorta differ between normotensive and hypertensive rats.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Body Weight; Genistein; Heart Rate; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Potassium Channel Blockers; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 2006 |
Possible role of nitric oxide in the locomotor activity of hypertensive rats.
Topics: Animals; Antigens, CD; Behavior, Animal; Blood Pressure; Brain; Cyclic GMP; Enzyme Inhibitors; Gene Expression; Hypertension; Male; Motor Activity; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar | 2006 |
Role of AT1 receptors in permeability of the blood-brain barrier in diabetic hypertensive rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzimidazoles; Biphenyl Compounds; Blood Glucose; Blood Pressure; Blood-Brain Barrier; Body Weight; Brain; Capillary Permeability; Diabetes Mellitus, Experimental; Epinephrine; Evans Blue; Glutathione; Hypertension; Indicators and Reagents; Lipid Peroxidation; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Superoxide Dismutase; Tetrazoles; Time Factors | 2006 |
Effect of lisinopril on rat liver tissues in L-NAME induced hypertension model.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; Lisinopril; Liver; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Random Allocation; Rats; Rats, Sprague-Dawley | 2007 |
NO synthase uncoupling in the kidney of Dahl S rats: role of dihydrobiopterin.
Topics: Animals; Biopterins; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Kidney; Kidney Medulla; Male; NG-Nitroarginine Methyl Ester; Oxidative Stress; Rats; Rats, Inbred Dahl; Superoxides | 2006 |
Increased wall tension in response to vasoconstrictors in isolated mesenteric arterial rings from patients with high blood pressure.
Topics: Adult; Aged; Aged, 80 and over; Diclofenac; Female; Humans; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Middle Aged; NG-Nitroarginine Methyl Ester; Nifedipine; Norepinephrine; Potassium Chloride; Serotonin; Vasoconstriction; Vasoconstrictor Agents | 2006 |
The time-dependent effect of Provinols on brain NO synthase activity in L-NAME-induced hypertension.
Topics: Animals; Blood Pressure; Brain; Flavonoids; Hypertension; Male; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxidative Stress; Phenols; Polyphenols; Rats; Rats, Wistar; Wine | 2006 |
Cerebral blood flow autoregulation and edema formation during pregnancy in anesthetized rats.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Edema; Capillary Permeability; Cerebrovascular Circulation; Enzyme Inhibitors; Female; Fluorescein; Fluorescent Dyes; Homeostasis; Hypertension; Laser-Doppler Flowmetry; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenylephrine; Pregnancy; Pregnancy Complications; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 2007 |
Role of renal sympathetic nerve activity in hypertension induced by chronic nitric oxide inhibition.
Topics: Animals; Baroreflex; Blood Pressure; Heart Rate; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rabbits; Sympathetic Nervous System; Telemetry; Time Factors | 2007 |
Thymoquinone supplementation attenuates hypertension and renal damage in nitric oxide deficient hypertensive rats.
Topics: Animals; Antihypertensive Agents; Benzoquinones; Creatine; Glutathione; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nigella sativa; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Phytotherapy; Plant Oils; Rats; Rats, Wistar | 2007 |
Effects of chronic nitric oxide synthase inhibition on the cardiovascular responses to cannabinoids in vivo and in vitro.
Topics: Animals; Arachidonic Acids; Benzoxazines; Blood Pressure; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Mesenteric Arteries; Morpholines; Muscle, Skeletal; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Renal Circulation; Splanchnic Circulation; Time Factors; Vascular Resistance; Vasoconstriction; Vasodilation; Vasodilator Agents | 2007 |
Cardiovascular protection with sildenafil following chronic inhibition of nitric oxide synthase.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Antihypertensive Agents; Carbolines; Cardiomyopathies; Cardiovascular Agents; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Doxorubicin; Endothelium, Vascular; Enzyme Inhibitors; Erectile Dysfunction; Heart Failure; Humans; Hypertension; Hypertension, Pulmonary; Imidazoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase Inhibitors; Piperazines; Purines; Sildenafil Citrate; Sulfones; Tadalafil; Triazines; Vardenafil Dihydrochloride; Vasodilator Agents; Ventricular Remodeling | 2007 |
Sildenafil reduces L-NAME-induced severe hypertension and worsening of myocardial ischaemia-reperfusion damage in the rat.
Topics: Animals; Antihypertensive Agents; Biomarkers; Blood Pressure; Cardiovascular Agents; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Severity of Illness Index; Sildenafil Citrate; Sulfones; Time Factors; Vasodilation; Vasodilator Agents; Ventricular Function | 2007 |
Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II.
Topics: Angiotensin II; Animals; Aorta; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biopterins; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Glutathione Disulfide; Hypertension; Isoenzymes; Male; Mice; Mice, Inbred Strains; Mice, Knockout; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Superoxides; Vasodilation | 2007 |
Role of nitric oxide in alpha-melanocyte-stimulating hormone-induced hypotension in the nucleus tractus solitarii of the spontaneously hypertensive rats.
Topics: alpha-MSH; Animals; Blood Pressure; Cell Line, Tumor; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Hypertension; Male; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Receptor, Melanocortin, Type 4; Signal Transduction; Solitary Nucleus | 2007 |
C-reactive protein causes downregulation of vascular angiotensin subtype 2 receptors and systolic hypertension in mice.
Topics: Angiotensin II; Animals; Benzimidazoles; Benzoates; C-Reactive Protein; Down-Regulation; Hypertension; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Systole; Telmisartan | 2007 |
The in vitro and in vivo cardiovascular effects of Delta9-tetrahydrocannabinol in rats made hypertensive by chronic inhibition of nitric-oxide synthase.
Topics: Animals; Blood Pressure; Dronabinol; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Vasodilation | 2007 |
Modulation of vascular reactivity in normal, hypertensive and diabetic rat aortae by a non-antioxidant flavonoid.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Cyclic GMP; Cyclooxygenase Inhibitors; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Flavones; Flavonoids; Guanylate Cyclase; Hypertension; Indomethacin; Male; Methylene Blue; Muscle, Smooth, Vascular; NAD; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 2007 |
Sympathetic activation in rats with L-NAME-induced hypertension.
Topics: Animals; Cardiac Output; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sympathetic Nervous System; Vascular Resistance | 2007 |
Up-regulation of arginase activity contributes to attenuated reflex cutaneous vasodilatation in hypertensive humans.
Topics: Arginase; Arginine; Blood Flow Velocity; Body Temperature; Boronic Acids; Case-Control Studies; Enzyme Inhibitors; Female; Humans; Hypertension; Laser-Doppler Flowmetry; Male; Microdialysis; Middle Aged; NG-Nitroarginine Methyl Ester; Reflex; Skin; Up-Regulation; Vasodilation | 2007 |
The herbal medicines Saireito and Boiogito improve the hypertension of pre-eclamptic rats induced by Nomega-Nitro-L-arginine methyl ester.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Drugs, Chinese Herbal; Female; Hypertension; Japan; Male; Medicine, East Asian Traditional; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phytotherapy; Plants, Medicinal; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley | 2007 |
Antihypertensive mechanisms of chronic captopril or N-acetylcysteine treatment in L-NAME hypertensive rats.
Topics: Acetylcysteine; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Pentolinium Tartrate; Rats; Rats, Wistar; Tetraethylammonium | 2006 |
Hepatic morphological alterations, glycogen content and cytochrome P450 activities in rats treated chronically with N(omega)-nitro-L-arginine methyl ester (L-NAME).
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Chronic Disease; Cytochrome P-450 Enzyme System; Enalapril; Enzyme Activation; Enzyme Inhibitors; Fasting; Glucose; Glycogen; Glycogen Synthase Kinase 3; Hypertension; Hypertrophy; Liver; Liver Cirrhosis; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptidyl-Dipeptidase A; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Renin-Angiotensin System | 2007 |
Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury.
Topics: Aging; Aldosterone; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Benzimidazoles; Biomarkers; Biphenyl Compounds; Blood Pressure; Cardiovascular System; Critical Period, Psychological; Drug Administration Schedule; Enzyme Inhibitors; Hypertension; Kidney; Male; Mortality; NG-Nitroarginine Methyl Ester; Oxidative Stress; Proteinuria; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; Tetrazoles; Vasoconstrictor Agents | 2007 |
Antihypertensive effect of an aqueous extract of the calyx of Hibiscus sabdariffa.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Flowers; Heart Rate; Hibiscus; Hypertension; Injections, Intravenous; NG-Nitroarginine Methyl Ester; Phytotherapy; Plant Extracts; Rats; Rats, Wistar; Sodium Chloride | 2007 |
Local ascorbate administration augments NO- and non-NO-dependent reflex cutaneous vasodilation in hypertensive humans.
Topics: Administration, Cutaneous; Antioxidants; Arginase; Ascorbic Acid; Blood Flow Velocity; Blood Vessels; Boronic Acids; Case-Control Studies; Enzyme Inhibitors; Female; Fever; Humans; Hypertension; Laser-Doppler Flowmetry; Male; Microdialysis; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Reflex; Skin; Time Factors; Vasodilation | 2007 |
Ferulic acid restores endothelium-dependent vasodilation in aortas of spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Coumaric Acids; Cyclic GMP; Endothelium, Vascular; Hydroquinones; Hypertension; Male; NADP; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides; Thromboxane B2; Vasodilation | 2007 |
Ethanol inhibitory effect on rat kidney brush border aminopeptidases.
Topics: Animals; Blood Pressure; CD13 Antigens; Central Nervous System Depressants; Enzyme Inhibitors; Ethanol; Gene Expression Regulation, Enzymologic; Glutamyl Aminopeptidase; Hypertension; Kidney Cortex; Male; Microvilli; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Random Allocation; Rats; Rats, Sprague-Dawley | 2007 |
Chronic resveratrol enhances endothelium-dependent relaxation but does not alter eNOS levels in aorta of spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Endothelium; Hydrogen Peroxide; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Nitroprusside; Rats; Rats, Inbred SHR; Reactive Oxygen Species; Resveratrol; Stilbenes; Vasodilation; Vasodilator Agents | 2007 |
Effect of maturation on renal Na+/K+-atpase and its susceptibility to nitric oxide-deficient hypertension in rats.
Topics: Adenosine Triphosphate; Age Factors; Aging; Animals; Binding Sites; Blood Pressure; Disease Models, Animal; Hypertension; Kidney; Kinetics; Male; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Sodium Chloride; Sodium-Potassium-Exchanging ATPase | 2007 |
Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage.
Topics: Albuminuria; Angiotensin II; Animals; Atherosclerosis; Cells, Cultured; Endothelial Cells; Gene Expression Regulation; Humans; Hypertension; I-kappa B Proteins; Inflammation; Intercellular Adhesion Molecule-1; Kidney Diseases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Models, Cardiovascular; Nephritis; NF-kappa B; NF-KappaB Inhibitor alpha; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Organ Specificity; Receptor, TIE-1; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Sodium Chloride, Dietary; Tumor Necrosis Factor-alpha; Vascular Cell Adhesion Molecule-1 | 2007 |
N(G)-nitro-L-arginine methyl ester, but not methylene blue, attenuates anaphylactic hypotension in anesthetized mice.
Topics: Anaphylaxis; Anesthesia; Animals; Blood Pressure; Enzyme Inhibitors; Guanylate Cyclase; Hypertension; Liver Circulation; Male; Methylene Blue; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Ovalbumin; Oxadiazoles; Quinoxalines | 2007 |
Role of nitric oxide in salt and water excretion in experimental hypertension in hooded (Aguti) rats.
Topics: Animals; Disease Models, Animal; Drinking; Hypertension; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium; Random Allocation; Rats; Sodium; Sodium Chloride; Urine | 2007 |
Vascular effects of long-term propranolol administration after chronic nitric oxide blockade.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Biological Factors; Blood Pressure; Calcium; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Potassium; Propranolol; Rats; Rats, Wistar; Superoxide Dismutase; Time Factors; Vasodilation; Vasodilator Agents | 2007 |
Evidence that the vasodilator angiotensin-(1-7)-Mas axis plays an important role in erectile function.
Topics: Angiotensin I; Angiotensin II; Animals; Desoxycorticosterone; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Erectile Dysfunction; Hypertension; Immunohistochemistry; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penile Erection; Penis; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Sodium Chloride, Dietary; Vasodilator Agents | 2007 |
Internal mammary artery grafts reactivity in hypertensive patients: role of stretching in extraendothelial nitric oxide.
Topics: Aged; Angiotensin II; Biomechanical Phenomena; Endothelium, Vascular; Enzyme Inhibitors; Female; Humans; Hypertension; In Vitro Techniques; Male; Mammary Arteries; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Norepinephrine; Potassium Chloride; Stress, Mechanical; Vasodilation | 2007 |
l-carnitine and its propionate: improvement of endothelial function in SHR through superoxide dismutase-dependent mechanisms.
Topics: Animals; Antioxidants; Blood Pressure; Carnitine; Endothelium, Vascular; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Superoxide Dismutase; Superoxides | 2007 |
Tissue inhibitor of metalloproteinase-3 deficiency inhibits blood pressure elevation and myocardial microvascular remodeling induced by chronic administration of Nomega-nitro-L-arginine methyl ester in mice.
Topics: Animals; Blood Pressure; Coronary Circulation; Coronary Vessels; Fibrosis; Hypertension; Mice; Mice, Inbred C57BL; Mice, Knockout; Microcirculation; Myocardium; NG-Nitroarginine Methyl Ester; Oxidative Stress; Tissue Inhibitor of Metalloproteinase-3 | 2007 |
Acute immune and non-immune inflammatory response in spontaneously hypertensive rats and normotensive rats. Role of endogenous nitric oxide.
Topics: Anaphylaxis; Animals; Capillary Permeability; Carrageenan; Cell Migration Assays, Leukocyte; Chemotaxis, Leukocyte; Disease Models, Animal; Enzyme Inhibitors; Exudates and Transudates; Hypertension; Leukocytes; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ovalbumin; Pleurisy; Rats; Rats, Inbred SHR; Rats, Wistar | 2007 |
Effects of pioglitazone and rosiglitazone on aortic vascular function in rat genetic hypertension.
Topics: Acetylcholine; Animals; Aorta; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; Indomethacin; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Pioglitazone; Prostaglandins; Rats; Rats, Inbred SHR; Rosiglitazone; Thiazolidinediones; Vasoconstriction; Vasoconstrictor Agents | 2007 |
Chronic and acute effects of different antihypertensive drugs on femoral artery relaxation of L-NAME hypertensive rats.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Captopril; Disease Models, Animal; Diuretics; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Femoral Artery; Heart Ventricles; Hydrochlorothiazide; Hypertension; Hypertrophy, Left Ventricular; Indapamide; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 2007 |
Effect of blood pressure on L-NAME-sensitive component of vasorelaxation in adult rats.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Femoral Artery; Heart Ventricles; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Severity of Illness Index; Vasodilation; Vasodilator Agents | 2007 |
Spontaneous, L-arginine-induced and spironolactone-induced regression of protein remodeling of the left ventricle in L-NAME-induced hypertension.
Topics: Animals; Arginine; Blood Pressure; Collagen; Hypertension; Hypertrophy, Left Ventricular; Male; Mineralocorticoid Receptor Antagonists; Muscle Proteins; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Remission, Spontaneous; Spironolactone; Ventricular Remodeling | 2007 |
Simvastatin decreased coenzyme Q in the left ventricle and skeletal muscle but not in the brain and liver in L-NAME-induced hypertension.
Topics: Animals; Brain; Coenzymes; Disease Models, Animal; Down-Regulation; Heart Ventricles; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hypertension; Liver; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Simvastatin; Time Factors; Ubiquinone | 2007 |
Spironolactone differently influences remodeling of the left ventricle and aorta in L-NAME-induced hypertension.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cell Proliferation; DNA Replication; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Kidney; Male; Mineralocorticoid Receptor Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Spironolactone; Time Factors; Ventricular Remodeling | 2007 |
Nitric oxide synthesis blockade increases hypertrophy and cardiac fibrosis in rats submitted to aerobic training.
Topics: Adaptation, Physiological; Analysis of Variance; Animals; Blood Pressure; Disease Models, Animal; Endomyocardial Fibrosis; Enzyme Inhibitors; Heart Rate; Hypertension; Hypertrophy, Left Ventricular; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Physical Conditioning, Animal; Rats; Rats, Wistar; Swimming | 2007 |
Nitric oxide modulates air embolism-induced lung injury in rats with normotension and hypertension.
Topics: Animals; Blood Pressure; Capillary Permeability; Cyclic GMP; Disease Models, Animal; Embolism, Air; Enzyme Inhibitors; Hypertension; Interleukin-1beta; Lung; Lysine; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type II; Nitroprusside; Organ Size; Perfusion; Proteins; Pulmonary Artery; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Respiratory Distress Syndrome; S-Nitroso-N-Acetylpenicillamine; Tumor Necrosis Factor-alpha | 2007 |
Chromosomal mapping of the genetic basis of hypertension and renal disease in FHH rats.
Topics: Albuminuria; Animals; Blood Pressure; Chromosome Mapping; Creatinine; Enzyme Inhibitors; Female; Heart Rate; Hypertension; Kidney Diseases; Male; NG-Nitroarginine Methyl Ester; Phenotype; Proteinuria; Rats; Rats, Inbred BN; Renin; Sex Characteristics; Species Specificity; X Chromosome; Y Chromosome | 2007 |
Small artery remodeling and erythrocyte deformability in L-NAME-induced hypertension: role of transglutaminases.
Topics: Animals; Blood Pressure; Clodronic Acid; Disease Models, Animal; Enzyme Inhibitors; Erythrocyte Deformability; Factor XIII; GTP-Binding Proteins; Hematocrit; Hypertension; Macrophages; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Protein Glutamine gamma Glutamyltransferase 2; Research Design; Stress, Mechanical; Time Factors; Transglutaminases | 2008 |
Superoxide and its interaction with nitric oxide modulates renal function in prehypertensive Ren-2 transgenic rats.
Topics: Animals; Animals, Genetically Modified; Blood Pressure; Cyclic N-Oxides; Glomerular Filtration Rate; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Sodium; Spin Labels; Superoxides | 2007 |
Vascular function and nitric oxide production in chronic social-stress-exposed rats with various family history of hypertension.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Body Weight; Crowding; Dose-Response Relationship, Drug; Female; Femoral Artery; Heart Rate; Hypertension; Hypothalamus; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Wistar; Serotonin; Social Behavior; Species Specificity; Stress, Psychological; Vasodilation | 2007 |
Acute antihypertensive action of Tempol in the spontaneously hypertensive rat.
Topics: Amitrole; Animals; Antihypertensive Agents; Blood Pressure; Buthionine Sulfoximine; Catalase; Cromakalim; Cyclic N-Oxides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ganglionic Blockers; Glutathione Peroxidase; Glyburide; Heart Rate; Heme Oxygenase (Decyclizing); Hexamethonium; Hypertension; Infusions, Intravenous; KATP Channels; Large-Conductance Calcium-Activated Potassium Channels; Male; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptides; Potassium Channel Blockers; Rats; Rats, Inbred SHR; Spin Labels; Sympathetic Nervous System; Time Factors | 2007 |
Renal sodium-glucose cotransporter activity and aquaporin-2 expression in rat kidney during chronic nitric oxide synthase inhibition.
Topics: Adaptation, Physiological; Animals; Aquaporin 2; Blood Pressure; Diuresis; Drug Administration Schedule; Enzyme Inhibitors; Glucose; Hypertension; Kidney; Kidney Medulla; Male; Membrane Lipids; Microvilli; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sodium-Glucose Transporter 2; Sodium-Glucose Transporter 2 Inhibitors; Tissue Distribution | 2007 |
Oxidative stress attenuates NO-induced modulation of sympathetic neurotransmission in the mesenteric arterial bed of spontaneously hypertensive rats.
Topics: Acetylcysteine; Animals; Antioxidants; Arginine; Blood Pressure; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Hypertension; Male; Mesenteric Arteries; Neuropeptide Y; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Oxidative Stress; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Neuropeptide Y; Splanchnic Circulation; Superoxides; Sympathetic Nervous System | 2008 |
Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals.
Topics: Animals; Arginine; Blood Pressure; Disease Models, Animal; Diuresis; Enzyme Inhibitors; Hydronephrosis; Hypertension; Indazoles; Kidney; Kidney Cortex; Kidney Tubules, Proximal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium Chloride, Dietary; Ureteral Obstruction | 2008 |
Antihypertensive effect of biotin in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Biotin; Coronary Vessels; Genetic Predisposition to Disease; Glucose Tolerance Test; Guanylate Cyclase; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Quinoxalines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stroke; Time; Vitamins | 2008 |
Arbutus unedo prevents cardiovascular and morphological alterations in L-NAME-induced hypertensive rats Part I: cardiovascular and renal hemodynamic effects of Arbutus unedo in L-NAME-induced hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Ericaceae; Hemodynamics; Hypertension; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Organ Size; Plant Extracts; Rats; Rats, Wistar | 2008 |
Effect of antioxidants pQ510 and resveratrol on regulatory function of the endothelium in rats with modeled arterial hypertension.
Topics: Animals; Antioxidants; Ascorbic Acid; Endothelium, Vascular; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organometallic Compounds; Rats; Rats, Wistar; Resveratrol; Stilbenes | 2007 |
Decreased NO signaling leads to enhanced vasoconstrictor responsiveness in skeletal muscle arterioles of the ZDF rat prior to overt diabetes and hypertension.
Topics: Animals; Arterioles; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Disease Models, Animal; Disease Progression; Dose-Response Relationship, Drug; Down-Regulation; Endothelin-1; Enzyme Inhibitors; Hypertension; Insulin; Isoproterenol; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Norepinephrine; Potassium Chloride; Prediabetic State; Rats; Rats, Zucker; Signal Transduction; Superoxide Dismutase; Superoxide Dismutase-1; Time Factors; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2008 |
Pregnancy reverses hypertensive remodeling of cerebral arteries.
Topics: Adaptation, Physiological; Animals; Blood Pressure; Cerebral Arteries; Cerebrovascular Circulation; Disease Models, Animal; Enzyme Inhibitors; Female; Homeostasis; Hypertension; Models, Cardiovascular; NG-Nitroarginine Methyl Ester; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy, Animal; Rats; Rats, Sprague-Dawley | 2008 |
Estrogen, nitric oxide, and hypertension differentially modulate agonist-induced contractile responses in female transgenic (mRen2)27 hypertensive rats.
Topics: Angiotensin II; Animals; Animals, Genetically Modified; Aorta; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Estradiol; Female; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Ovariectomy; Phenylephrine; Rats; Rats, Sprague-Dawley; Renin; Serotonin; Vasoconstriction; Vasoconstrictor Agents | 2008 |
Regulatory role of nitric oxide on the cardiac Na, K-ATPase in hypertension.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Blood Pressure; Disease Models, Animal; Energy Metabolism; Enzyme Inhibitors; Hypertension; Kinetics; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Sodium Chloride; Sodium-Potassium-Exchanging ATPase | 2008 |
Short-term effects of glucosyl hesperidin and hesperetin on blood pressure and vascular endothelial function in spontaneously hypertensive rats.
Topics: Acetylcholine; Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Therapy, Combination; Endothelium, Vascular; Enzyme Inhibitors; Glucosides; Hesperidin; Hypertension; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Organ Culture Techniques; Rats; Rats, Inbred SHR; Rats, Wistar; Time; Vasodilation; Vasodilator Agents | 2008 |
Angiotensin II type 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in Dahl salt-sensitive rat heart.
Topics: Aldehydes; Amidines; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzylamines; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hypertension; Losartan; Male; Malondialdehyde; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Tiopronin; Up-Regulation; Ventricular Function, Left | 2008 |
Nitric oxide deficiency and increased adenosine response of afferent arterioles in hydronephrotic mice with hypertension.
Topics: Adenosine; Angiotensin II; Animals; Arterioles; Disease Models, Animal; Enzyme Inhibitors; Hydronephrosis; Hypertension; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidative Stress; Superoxide Dismutase; Superoxide Dismutase-1; Transforming Growth Factors; Vasoconstriction; Vasoconstrictor Agents | 2008 |
Tx2-6 toxin of the Phoneutria nigriventer spider potentiates rat erectile function.
Topics: Animals; Disease Models, Animal; Drug Synergism; Electric Stimulation; Erectile Dysfunction; Hypertension; Male; Neuropeptides; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Penile Erection; Penis; Rats; Rats, Wistar; Spider Venoms; Spiders | 2008 |
Anti-hypertensive effects of the methanol/methylene chloride stem bark extract of Mammea africana in l-NAME-induced hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Carbachol; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Mammea; Methanol; Methylene Chloride; Muscarinic Agonists; Muscle, Smooth, Vascular; Myocardium; NG-Nitroarginine Methyl Ester; Organ Size; Phytotherapy; Plant Bark; Plant Extracts; Plant Stems; Rats; Rats, Wistar; Solvents | 2008 |
Regression of left ventricular hypertrophy and aortic remodelling in NO-deficient hypertensive rats: effect of L-arginine and spironolactone.
Topics: Animals; Aorta; Arginine; Fibrosis; Hypertension; Hypertrophy, Left Ventricular; Male; Mineralocorticoid Receptor Antagonists; Models, Animal; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Spironolactone | 2008 |
Post-resistance exercise hypotension in spontaneously hypertensive rats is mediated by nitric oxide.
Topics: Animals; Blood Pressure; Hexamethonium; Hypertension; Hypotension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physical Conditioning, Animal; Rats; Rats, Inbred SHR | 2008 |
Alpha2-antiplasmin is a critical regulator of angiotensin II-mediated vascular remodeling.
Topics: Angiotensin II; Animals; Apoptosis; Cardiomegaly; Cell Proliferation; Collagen Type I; Cyclin-Dependent Kinase Inhibitor p21; Disease Models, Animal; Eye Proteins; Fibrosis; Gelatinases; Hypertension; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; Nerve Growth Factors; NG-Nitroarginine Methyl Ester; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Proto-Oncogene Proteins c-myc; Serpins; Thoracic Arteries; Tumor Suppressor Protein p53 | 2008 |
Malignant alterations following early blockade of nitric oxide synthase in hypertensive rats.
Topics: Animals; Blood Pressure; Blood Urea Nitrogen; Body Weight; Endothelin-1; Enzyme Inhibitors; Glomerular Filtration Rate; Hypertension; Isothiuronium; Kidney; Kidney Function Tests; Lysine; Muscle Weakness; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Nitroarginine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Ventricular Function, Left | 2007 |
Soy protein hydrolysate ameliorates cardiovascular remodeling in rats with L-NAME-induced hypertension.
Topics: Alanine Transaminase; Animals; Aorta; Aspartate Aminotransferases; Blood Pressure; Hydrolysis; Hypertension; Lipids; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitrites; Rats; Rats, Wistar; Soybean Proteins; Ventricular Remodeling | 2008 |
Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats.
Topics: Animals; Arginine; Blood Pressure; Cardiomegaly; Coronary Circulation; Coronary Vessels; Data Interpretation, Statistical; Enzyme Inhibitors; Fibrosis; Heart; Heart Rate; Histological Techniques; Hydralazine; Hypertension; Male; Microcirculation; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred WKY | 1995 |
L-arginine infusion promotes nitric oxide-dependent vasodilation, increases regional cerebral blood flow, and reduces infarction volume in the rat.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Carbon Dioxide; Cerebral Infarction; Cerebrovascular Circulation; Hypertension; Infusions, Intravenous; Ischemic Attack, Transient; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxygen; Partial Pressure; Pia Mater; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Regional Blood Flow | 1994 |
[Sodium intake and angiotensin in hypertension induced by chronic NO synthase inhibition in the rat].
Topics: Amino Acid Oxidoreductases; Angiotensin II; Animals; Arginine; Diet, Sodium-Restricted; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sodium, Dietary | 1993 |
Increased endothelium-derived NO in hypertensive pulmonary circulation of chronically hypoxic rats.
Topics: Animals; Arginine; Chronic Disease; Hypertension; Hypoxia; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pulmonary Circulation; Rats; Rats, Sprague-Dawley; Substance P; Vasoconstriction | 1994 |
Role of kinins and nitric oxide in the antihypertrophic effect of ramipril.
Topics: Amino Acid Oxidoreductases; Animals; Aortic Coarctation; Arginine; Blood Pressure; Cardiomegaly; Dose-Response Relationship, Drug; Heart Ventricles; Hypertension; Kinins; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Ramipril; Rats | 1994 |
Spinal cord infarcts during long-term inhibition of nitric oxide synthase in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arteries; Brain; Hypertension; Infarction; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Spinal Cord | 1994 |
Nitric oxide mediates the hypertensive response to a modified hemoglobin solution (DCLHb) in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Aspirin; Hemodynamics; Hemoglobins; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Solutions | 1994 |
Endogenous nitric oxide synthesis determines sensitivity to the pressor effect of salt.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Hypertension; Kidney Glomerulus; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Nitrogen Dioxide; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium Chloride, Dietary | 1994 |
[Study on roles of L-arginine to nitric oxide pathway for the cardiovascular control: assessment with a new model of hypertension produced by the chronic administration of nitric oxide synthase inhibitor].
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cell Division; Chronic Disease; Disease Models, Animal; Hemodynamics; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Wistar; Sympathetic Nervous System | 1994 |
Hormonal, renal, and metabolic alterations during hypertension induced by chronic inhibition of NO in rats.
Topics: Aldosterone; Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Creatinine; Diuresis; Dopamine; Epinephrine; Hypertension; Kidney; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Rats; Rats, Sprague-Dawley; Renin | 1994 |
Resistance artery structure and neuroeffector mechanisms in hypertension induced by inhibition of nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arteries; Hypertension; Methoxamine; Neuroeffector Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Rats; Rats, Sprague-Dawley | 1994 |
Ramipril prevents the detrimental sequels of chronic NO synthase inhibition in rats: hypertension, cardiac hypertrophy and renal insufficiency.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Cardiomegaly; Cyclic GMP; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ramipril; Rats; Rats, Wistar; Renal Insufficiency; Ventricular Fibrillation | 1994 |
Assessment of renal dopaminergic system activity in the nitric oxide-deprived hypertensive rat model.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Aromatic-L-Amino-Acid Decarboxylases; Blood Pressure; Disease Models, Animal; Dopamine; Drinking; Heart Rate; Hypertension; Kidney; Kinetics; Levodopa; Male; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Urination | 1995 |
Nifedipine prevents renal injury in rats with chronic nitric oxide inhibition.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Arginine; Blood Pressure; Calcium Channel Blockers; Hemodynamics; Hypertension; In Vitro Techniques; Kidney; Kidney Glomerulus; Male; Nephritis, Interstitial; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Norepinephrine; Prostaglandin Endoperoxides, Synthetic; Rats; Rats, Wistar; Thromboxane A2; Time Factors; Vasoconstrictor Agents | 1995 |
Effects of chronic NO synthase inhibition in rats on renin-angiotensin system and sympathetic nervous system.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Antihypertensive Agents; Arginine; Biphenyl Compounds; Blood Pressure; Brain; Creatinine; Diet, Sodium-Restricted; Epinephrine; Heart Rate; Hypertension; Imidazoles; Kidney; Losartan; Male; Neuropeptide Y; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Phentolamine; Rats; Rats, Wistar; Reference Values; Renin; Renin-Angiotensin System; Sympathetic Nervous System; Tetrazoles; Weight Gain | 1995 |
Endothelium-dependent relaxation of small arteries from essential hypertensive patients: mechanisms and comparison with normotensive subjects and with responses of vessels from spontaneously hypertensive rats.
Topics: Acetylcholine; Adult; Animals; Apamin; Arginine; Arterioles; Charybdotoxin; Endothelium, Vascular; Humans; Hypertension; In Vitro Techniques; Indomethacin; Male; Methylene Blue; Middle Aged; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Ouabain; Potassium Chloride; Rats; Rats, Inbred SHR; Scorpion Venoms; Tolbutamide; Vasoconstriction | 1995 |
Nitric oxide synthase inhibition in spontaneously hypertensive rats. Systemic, renal, and glomerular hemodynamics.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Hemodynamics; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Renal Circulation | 1995 |
Contribution of vascular nitric oxide to basal blood pressure in conscious spontaneously hypertensive rats and normotensive Wistar Kyoto rats.
Topics: Animals; Antihypertensive Agents; Arginine; Blood Pressure; Captopril; Endothelium, Vascular; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentolinium Tartrate; Piperidines; Quinolones; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1995 |
Sympathetically mediated hypertension caused by chronic inhibition of nitric oxide.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Bradykinin; Chlorisondamine; Female; Femoral Artery; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Sympathectomy; Sympathetic Nervous System; Time Factors | 1995 |
Structure and function of the rat basilar artery during chronic nitric oxide synthase inhibition.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arginine; Basilar Artery; Blood Pressure; Cerebrovascular Circulation; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Hypertension; Image Processing, Computer-Assisted; Indoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Serotonin; Vasodilator Agents; Verapamil; Video Recording | 1995 |
Effect of aging and hypertension on contractility of resistance arteries: modulation by endothelial factors.
Topics: Aging; Angiotensins; Animals; Arginine; Arteries; Blood Pressure; Body Weight; Endothelium, Vascular; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents | 1995 |
Role of nitric oxide in disruption of the blood-brain barrier during acute hypertension.
Topics: Acute Disease; Animals; Arginine; Blood-Brain Barrier; Brain; Enzyme Inhibitors; Fluorescein-5-isothiocyanate; Hypertension; Male; Metabolic Clearance Rate; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Phenylephrine; Rats | 1995 |
L-NAME hypertension alters endothelial and smooth muscle function in rat aorta. Prevention by trandolapril and verapamil.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Arginine; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Indoles; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Vasoconstriction; Vasodilator Agents; Verapamil | 1995 |
Roles of nitric oxide and endothelium-derived hyperpolarizing factor in vasorelaxant effect of acetylcholine as influenced by aging and hypertension.
Topics: Acetylcholine; Aging; Animals; Arginine; Biological Factors; Blood Pressure; Hypertension; In Vitro Techniques; Muscle Tonus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Splanchnic Circulation; Tetraethylammonium Compounds; Vasodilation | 1995 |
Enhanced responses to L-arginine in aortic rings from rats with angiotensin-dependent hypertension.
Topics: Angiotensin II; Animals; Aorta; Aortic Coarctation; Arginine; Blood Pressure; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley | 1995 |
Attenuated Ca2+ response to acetylcholine in endothelial cells from aorta of aldosterone-salt hypertensive rats.
Topics: Acetylcholine; Aldosterone; Animals; Arginine; Calcium; Endothelium, Vascular; Fura-2; Hypertension; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Rats; Rats, Sprague-Dawley; Sodium Chloride | 1995 |
Plasma adrenaline responses to long-term modification of blood pressure in normotensive rats and hypertensive rats.
Topics: Animals; Arginine; Blood Pressure; Epinephrine; Hydralazine; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors | 1995 |
Nitric oxide and prostaglandins in the prolonged effects of losartan and ramipril in hypertension.
Topics: Animals; Antihypertensive Agents; Arginine; Biphenyl Compounds; Blood Pressure; Bradykinin; Drug Interactions; Hypertension; Imidazoles; Indomethacin; Kidney Function Tests; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Ramipril; Rats; Rats, Inbred SHR; Tetrazoles | 1995 |
Chronic L-NAME hypertension in rats and autoregulation of juxtamedullary preglomerular vessels.
Topics: Actins; Animals; Arginine; Blood Pressure; Blood Vessels; Chronic Disease; Hemodynamics; Homeostasis; Hypertension; Juxtaglomerular Apparatus; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Renal Circulation | 1995 |
Cardiovascular responses to long-term blockade of nitric oxide synthesis.
Topics: Acetylcholine; Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Blood Urea Nitrogen; Creatinine; Dogs; Heart Rate; Hypertension; Iliac Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Potassium; Pressoreceptors; Regional Blood Flow; Sodium; Water-Electrolyte Balance | 1993 |
Long-term administration of 1,3-dipropyl-8-sulphophenylxanthine (DPSPX) alters alpha 2-adrenoceptor-mediated effects at the pre- but not at the postjunctional level.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Arteries; Brimonidine Tartrate; Hypertension; Male; Neuroeffector Junction; NG-Nitroarginine Methyl Ester; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P1; Tail; Xanthines | 1994 |
Enhanced responses of the basilar artery to activation of endothelin-B receptors in stroke-prone spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Arginine; Basilar Artery; Drug Interactions; Endothelins; Hypertension; Indomethacin; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin B; Receptors, Endothelin; Species Specificity; Vasodilation | 1995 |
Endothelium is a target organ of parathyroid secretions in genetic hypertensive rats.
Topics: Animals; Arginine; Atrial Natriuretic Factor; Endothelins; Endothelium, Vascular; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Parathyroid Glands; Parathyroid Hormone; Rats; Rats, Inbred SHR | 1995 |
Regional haemodynamic effects of human and rat adrenomedullin in conscious rats.
Topics: Adrenomedullin; Angiotensin II; Animals; Antihypertensive Agents; Arginine; Blood Pressure; Calcitonin Gene-Related Peptide; Catheterization, Peripheral; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Humans; Hypertension; Hypotension; Laser-Doppler Flowmetry; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptide Fragments; Peptides; Random Allocation; Rats; Regional Blood Flow; Renal Circulation; Tachycardia; Vasopressins | 1995 |
Effects of chronic increased salt intake on nitric oxide synthesis inhibition-induced hypertension.
Topics: Animals; Arginine; Body Weight; Diet; Diuresis; Drinking; Endothelins; Glomerular Filtration Rate; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sodium Chloride, Dietary | 1995 |
Renal effects of acute amino acid infusion in hypertension induced by chronic nitric oxide blockade.
Topics: Animals; Arginine; Blood Pressure; Glomerular Filtration Rate; Glycine; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Vasodilation | 1995 |
Renal autacoids are involved in the stimulation of renin gene expression by low perfusion pressure.
Topics: Animals; Arginine; Blood Pressure; Drug Combinations; Gene Expression; Hypertension; Kidney; Male; Meclofenamic Acid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Perfusion; Prostaglandins; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger | 1994 |
Role of renal medullary blood flow in the development of L-NAME hypertension in rats.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Body Water; Hypertension; Infusions, Intravenous; Kidney Cortex; Kidney Medulla; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Sodium | 1995 |
Assessment of spontaneous baroreflex sensitivity in rats a new method using the concept of statistical dependence.
Topics: Animals; Arginine; Baroreflex; Blood Pressure; Denervation; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Physiology; Rats; Rats, Wistar; Reference Values; Rest; Sinus of Valsalva; Statistics as Topic | 1995 |
Effect of an angiotensin II receptor antagonist, TCV-116, on cardiac hypertrophy and coronary circulation in spontaneously hypertensive rats.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Arginine; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Cardiomegaly; Coronary Circulation; Coronary Vessels; Heart Rate; Hypertension; Hypertrophy, Left Ventricular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prodrugs; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles; Vascular Resistance | 1994 |
Isosorbide 5-mononitrate reverses high blood pressure in NG-nitro-L-arginine methyl ester treated rats.
Topics: Animals; Arginine; Blood Pressure; Brain; Dopamine; Drinking; Drug Interactions; Epinephrine; Heart Rate; Hypertension; Isosorbide Dinitrate; Male; Methoxyhydroxyphenylglycol; NG-Nitroarginine Methyl Ester; Norepinephrine; Rats; Rats, Wistar; Sympathetic Nervous System; Tissue Distribution; Vasodilator Agents | 1994 |
Evidence that the autonomic nervous system plays a major role in the L-NAME-induced hypertension in conscious rats.
Topics: Animals; Arginine; Atenolol; Atropine; Autonomic Nervous System; Blood Pressure; Ganglionic Blockers; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Trimethaphan; Vagus Nerve | 1993 |
Prolonged blockade of nitric oxide synthesis in gravid rats produces sustained hypertension, proteinuria, thrombocytopenia, and intrauterine growth retardation.
Topics: Animals; Arginine; Creatinine; Female; Fetal Growth Retardation; gamma-Glutamyltransferase; Hematocrit; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Count; Potassium; Pregnancy; Pregnancy Complications; Proteinuria; Rats; Rats, Wistar; Sodium; Thrombocytopenia | 1994 |
The effects of perfusion rate and NG-nitro-L-arginine methyl ester on cirazoline- and KCl-induced responses in the perfused mesenteric arterial bed of rats.
Topics: Adrenergic alpha-Agonists; Animals; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Hypertension; Imidazoles; In Vitro Techniques; Infusions, Intra-Arterial; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Chloride; Povidone; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Vasoconstriction | 1994 |
Decreased cardiac baroreflex sensitivity is not due to cardiac hypertrophy in NG-nitro-L-arginine methyl ester-induced hypertension.
Topics: Animals; Arginine; Baroreflex; Blood Pressure; Cardiomegaly; Heart; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Reference Values | 1994 |
Arterial contractions induced by cumulative addition of calcium in hypertensive and normotensive rats: influence of endothelium.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Calcium; Calcium Channels; Egtazic Acid; Endothelium, Vascular; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1994 |
Indomethacin does not modify the role of nitric oxide on blood pressure regulation of SHR.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Heart Rate; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Vasoconstriction | 1994 |
Norepinephrine-induced relaxations in rat aorta mediated by endothelial beta adrenoceptors. Impairment by ageing and hypertension.
Topics: Aging; Animals; Aorta; Arginine; Endothelium, Vascular; Hypertension; In Vitro Techniques; Isoproterenol; Male; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Norepinephrine; Ouabain; Propranolol; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, beta; Yohimbine | 1994 |
Pregnancy-induced hypertension in rats with early adriamycin nephropathy.
Topics: Angiotensin II; Animals; Arginine; Blood Pressure; Doxorubicin; Female; Hypertension; Nephrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylacetates; Pregnancy; Pregnancy Complications, Cardiovascular; Rats; Rats, Wistar; Receptors, Thromboxane; Sulfonamides | 1994 |
Baroreceptor reflex function in rats submitted to chronic inhibition of nitric oxide synthesis.
Topics: Animals; Arginine; Baroreflex; Blood Pressure; Bradycardia; Heart Rate; Hypertension; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Rats; Rats, Wistar; Tachycardia; Time Factors | 1994 |
Influence of endothelium on Mg(2+)-induced relaxation in noradrenaline-contracted aorta from DOCA-salt hypertensive rat.
Topics: Animals; Arginine; Desoxycorticosterone; Endothelium, Vascular; Hypertension; Magnesium; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Rats; Rats, Sprague-Dawley | 1994 |
Alterations in flow-dependent vasomotor tone in spontaneously hypertensive rats.
Topics: Animals; Arginine; Blood Pressure; Endothelium, Vascular; Hypertension; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regional Blood Flow; Species Specificity; Vascular Resistance; Vasodilation | 1994 |
Endothelium-derived nitric oxide partially mediates salbutamol-induced vasodilatations.
Topics: Albuterol; Animals; Aorta; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; In Vitro Techniques; Infusions, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Vasodilation | 1993 |
Nitric oxide and eicosanoid interactions in kidneys of Lyon hypertensive rats.
Topics: Animals; Arginine; Eicosanoids; Hypertension; In Vitro Techniques; Indomethacin; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Perfusion; Rats; Rats, Inbred SHR; Vascular Resistance | 1993 |
Effect of nitric oxide and prostaglandins on renal function in insulin-resistant hypertensive dogs.
Topics: Acetylcholine; Animals; Arginine; Disease Models, Animal; Diuresis; Dogs; Fructose; Glomerular Filtration Rate; Hypertension; Insulin Resistance; Kidney; Male; Meclofenamic Acid; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Renal Circulation | 1993 |
Increased activity in the nitric oxide pathway during chronic euglycemic hyperinsulinemia in the rat.
Topics: Animals; Arginine; Blood Glucose; Blood Pressure; Endothelium, Vascular; Hypertension; Insulin; Insulin Resistance; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley | 1993 |
Cerebrovascular autoregulation in response to hypertension induced by NG-nitro-L-arginine methyl ester.
Topics: Angiotensin II; Animals; Arginine; Autoradiography; Blood Pressure; Brain; Cerebrovascular Circulation; Glucose; Homeostasis; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley | 1994 |
Sodium excess aggravates hypertension and renal parenchymal injury in rats with chronic NO inhibition.
Topics: Animals; Arginine; Blood Pressure; Capillaries; Hypertension; Ischemia; Kidney; Kidney Glomerulus; Male; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sodium, Dietary | 1994 |
Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Glomerular Filtration Rate; Hematocrit; Hypertension; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Angiotensin; Reference Values; Regional Blood Flow; Renal Circulation; Tetrazoles; Vascular Resistance | 1994 |
Regional haemodynamics in Brattleboro rats during chronic ingestion of NG-nitro-L-arginine methyl ester.
Topics: Animals; Arginine; Hemodynamics; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Brattleboro; Renal Circulation; Vasoconstriction | 1993 |
Sympathetic denervation and the cerebrovascular response to hypertension induced by NG-nitro-L-arginine methyl ester.
Topics: Animals; Arginine; Blood Pressure; Cerebrovascular Circulation; Glucose; Homeostasis; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Sympathectomy | 1994 |
Alterations in coronary artery vascular reactivity of hypertensive Ren-2 transgenic rats.
Topics: Acetylcholine; Animals; Animals, Genetically Modified; Arginine; Coronary Vessels; Endothelium, Vascular; Hypertension; In Vitro Techniques; Molsidomine; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System | 1994 |
Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Aortic Coarctation; Arginine; Biphenyl Compounds; Blood Pressure; Hypertension; Imidazoles; In Vitro Techniques; Losartan; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction | 1994 |
Hypertension induced by nitric oxide synthesis inhibition is renal nerve dependent.
Topics: Animals; Arginine; Blood Pressure; Denervation; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Rats; Rats, Sprague-Dawley; Renin; Sympathetic Nervous System | 1994 |
The vasodilatory effect of endogenous nitric oxide is a major counter-regulatory mechanism in the spontaneously hypertensive rat.
Topics: Animals; Arginine; Blood Pressure; Cyclic GMP; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1993 |
Persistent hypertension following inhibition of nitric oxide formation in the young Wistar rat: role of renin and vascular hypertrophy.
Topics: Animals; Animals, Newborn; Arginine; Blood Pressure; Blood Vessels; Captopril; Dose-Response Relationship, Drug; Hypertension; Hypertrophy; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Renin | 1993 |
A non-cyclo-oxygenase, non-nitric oxide relaxing factor is present in resistance arteries of normotensive but not spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Arginine; Arteries; Endothelium, Vascular; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vascular Resistance; Vasodilation | 1994 |
Endothelium-derived relaxing factor, hypertension and chronic parathyroidectomy in spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Acetylcholine; Animals; Aorta; Arginine; Calcium; Cyclic GMP; Drug Interactions; Extracellular Space; Hypertension; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Norepinephrine; Parathyroid Glands; Parathyroidectomy; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1993 |
Long-term cardiovascular role of nitric oxide in conscious rats.
Topics: Animals; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Kidney; Male; Meclofenamic Acid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pressoreceptors; Rats; Rats, Sprague-Dawley; Renin | 1994 |
Salt-induced increase in arterial pressure during nitric oxide synthesis inhibition.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Dogs; Female; Glomerular Filtration Rate; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Sodium; Urination | 1993 |
Cardiac weight in hypertension induced by nitric oxide synthase blockade.
Topics: Angiotensins; Animals; Arginine; Atrial Natriuretic Factor; Dose-Response Relationship, Drug; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Myocardium; NG-Nitroarginine Methyl Ester; Organ Size; Rats; Rats, Wistar; Renin; Time Factors | 1993 |
Enhanced arteriolar vasomotion in rats with chronic salt-induced hypertension.
Topics: Animals; Arginine; Arterioles; Chronic Disease; Hypertension; Male; Muscles; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred Strains; Sodium, Dietary; Vasomotor System | 1993 |
Decreased arteriolar endothelium-derived relaxing factor production during the development of genetic hypertension.
Topics: Acetylcholine; Aging; Animals; Arginine; Arterioles; Hypertension; Male; Microcirculation; Muscles; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stimulation, Chemical | 1993 |
Sodium and angiotensin in hypertension induced by long-term nitric oxide blockade.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Diet, Sodium-Restricted; Electrolytes; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles; Time Factors | 1993 |
Hypertension inhibits noxious-evoked c-fos expression in the rat spinal cord.
Topics: Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Hypertension; Male; Neurons; NG-Nitroarginine Methyl Ester; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Spinal Cord; Time Factors | 1995 |
Endogenous nitric oxide is not involved in acute parathyroid hormone-induced hypotension in rat: effect of hypertension and hypoparathyroid status.
Topics: Animals; Arginine; Blood Pressure; Body Weight; Calcium; Enzyme Inhibitors; Hypertension; Hypoparathyroidism; Hypotension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Parathyroid Hormone; Parathyroidectomy; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1995 |
No evidence for vascular remodelling during hypertension induced by chronic inhibition of nitric oxide synthase in Brattleboro rats.
Topics: Animals; Arginine; Blood Pressure; Hypertension; Male; Mesenteric Arteries; Myography; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Brattleboro; Television; Time Factors; Vascular Resistance | 1995 |
[Effect of chronic inhibition of nitric oxide synthesis on vascular structure: remodeling or growth?].
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arginine; Basilar Artery; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Hypertension; Indoles; Muscle Development; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Verapamil | 1995 |
Exaggerated Bezold-Jarisch reflex in the hypertension induced by inhibition of nitric oxide synthesis.
Topics: Animals; Arginine; Blood Pressure; Enzyme Inhibitors; Heart Rate; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Reflex; Vasoconstriction | 1995 |
Vascular structure in hypertension induced by NG-nitro-L-arginine methyl ester: methodological considerations for studies of small arteries in hypertension--reply.
Topics: Animals; Arginine; Arteries; Hypertension; NG-Nitroarginine Methyl Ester; Rats | 1995 |
Cerebrovascular consequences of repeated exposure to NG-nitro-L-arginine methyl ester.
Topics: Animals; Arginine; Autoradiography; Blood Pressure; Brain; Cerebrovascular Circulation; Enzyme Inhibitors; Glucose; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Time Factors | 1995 |
Nitric oxide and the depressor response to angiotensin blockade in hypertension.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Coarctation; Arginine; Biphenyl Compounds; Blood Pressure; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ramipril; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Vasoconstrictor Agents | 1996 |
Endothelial function in deoxycorticosterone-NaCl hypertension: effect of calcium supplementation.
Topics: Acetylcholine; Adenosine Diphosphate; Animals; Apamin; Arginine; Blood Pressure; Calcium, Dietary; Desoxycorticosterone; Endothelium, Vascular; Glyburide; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nifedipine; Nitroprusside; Norepinephrine; Potassium Channels; Rats; Rats, Inbred WKY; Serotonin; Sodium Chloride; Vasodilation | 1996 |
The role of ETB receptors in normotensive and hypertensive rats as revealed by the non-peptide selective ETB receptor antagonist Ro 46-8443.
Topics: Animals; Arginine; Blood Pressure; Endothelin Receptor Antagonists; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides, Cyclic; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin B; Receptors, Endothelin; Sulfonamides; Viper Venoms | 1996 |
Role of renal nerves in mediating the hypertensive effects of nitric oxide synthesis inhibition.
Topics: Animals; Arginine; Blood Pressure; Denervation; Dogs; Enzyme Inhibitors; Hemodynamics; Hypertension; Infusions, Intra-Arterial; Infusions, Intravenous; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide | 1996 |
Role of nitric oxide in the maintenance of resting cerebral blood flow during chronic hypertension.
Topics: Animals; Arginine; Blood Pressure; Cerebrovascular Circulation; Chronic Disease; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sensitivity and Specificity | 1996 |
Effect of salt intake and inhibitor dose on arterial hypertension and renal injury induced by chronic nitric oxide blockade.
Topics: Albuminuria; Animals; Arginine; Diet, Sodium-Restricted; Dose-Response Relationship, Drug; Hemodynamics; Hypertension; Kidney; Kidney Diseases; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Renal Circulation; Renin; Time Factors | 1996 |
Central depressor action of nitric oxide is deficient in genetic hypertension.
Topics: Animals; Arginine; Blood Pressure; Brain; Cerebral Ventricles; Drug Administration Routes; Enzyme Inhibitors; Hypertension; Injections, Intraventricular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley | 1996 |
Preglomerular sudanophilia in L-NAME hypertensive rats: involvement of endothelin.
Topics: Animals; Arginine; Cell Division; Endothelins; Hypertension; Kidney Glomerulus; Lipid Metabolism; Male; NG-Nitroarginine Methyl Ester; Rats; Staining and Labeling | 1996 |
Comparison of effect of endothelin antagonism and angiotensin-converting enzyme inhibition on blood pressure and vascular structure in spontaneously hypertensive rats treated with N omega-nitro-L-arginine methyl ester. Correlation with topography of vascu
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Blood Pressure; Bosentan; Cilazapril; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Gene Expression; Hypertension; In Situ Hybridization; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Inbred SHR; Receptors, Endothelin; Renin; Sulfonamides; Vascular Resistance | 1996 |
A study of angiotensin II receptors after chronic inhibition of nitric oxide synthase in the spontaneously hypertensive rat.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Enzyme Inhibitors; Female; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Time Factors; Uterus | 1996 |
Vascular reactivity and flow-pressure curve in isolated kidneys from rats with N-nitro-L-arginine methyl ester-induced hypertension.
Topics: Acetylcholine; Animals; Arginine; Biological Factors; Blood Vessels; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Perfusion; Rats; Rats, Wistar | 1996 |
Effects of antihypertensive drugs on nitric oxide synthase activity in rat kidney.
Topics: Adrenergic alpha-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Hypertension; Immunohistochemistry; In Vitro Techniques; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1996 |
Differential regulation of kallikrein, kininogen, and kallikrein-binding protein in arterial hypertensive rats.
Topics: Animals; Arginine; Asialoglycoprotein Receptor; Bradykinin Receptor Antagonists; Cardiovascular System; Gene Expression; Hypertension; Kallikreins; Kininogens; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface | 1996 |
Long-term nitric oxide blockade in the pregnant rat: effects on blood pressure and plasma levels of endothelin-1.
Topics: Animals; Blood Pressure; Body Weight; Embryonic and Fetal Development; Endothelin-1; Female; Hypertension; Litter Size; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy, Animal; Rats; Rats, Sprague-Dawley; Time Factors | 1996 |
Role of ANG II in hypertension produced by chronic inhibition of nitric oxide synthase in conscious rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Enalapril; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reference Values; Tetrazoles; Time Factors | 1996 |
Pressure natriuresis following acute and chronic inhibition of nitric oxide synthase in rats.
Topics: Animals; Arginine; Blood Pressure; Glomerular Filtration Rate; Hypertension; Kidney; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reference Values; Renal Circulation; Time Factors | 1996 |
Inhibition of NO synthase in the posterior hypothalamus increases blood pressure in the rat.
Topics: Animals; Arginine; Blood Pressure; Data Interpretation, Statistical; Disease Models, Animal; Enzyme Inhibitors; Hypertension; Hypothalamus, Posterior; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar | 1995 |
Involvement of nitric oxide, but not prostaglandins, in the vascular sympathoinhibitory effects of losartan in the pithed spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Cyclooxygenase Inhibitors; Decerebrate State; Diclofenac; Electric Stimulation; Enzyme Inhibitors; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Rats; Rats, Inbred SHR; Regional Blood Flow; Spinal Cord; Sympatholytics; Tetrazoles | 1996 |
In vitro alteration of aortic vascular reactivity in hypertension induced by chronic NG-nitro-L-arginine methyl ester.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Cyclic GMP; Drug Combinations; Hypertension; In Vitro Techniques; Isoquinolines; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Quinapril; Rats; Rats, Wistar; Tetrahydroisoquinolines; Time Factors; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 1996 |
Hydrochlorothiazide exacerbates nitric oxide-blockade nephrosclerosis with glomerular hypertension in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Diuretics; Hemodynamics; Hydrochlorothiazide; Hypertension; Kidney; Male; Nephrosclerosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Proteinuria; Rats; Rats, Inbred SHR; Renal Circulation; Sodium Chloride Symporter Inhibitors; Vascular Resistance | 1996 |
Oral administration of the nitric oxide biosynthesis inhibitor, N-nitro-L-arginine methyl ester (L-NAME), causes hypertension, but not glucose intolerance or insulin resistance, in rats.
Topics: Administration, Oral; Animals; Arginine; Blood Glucose; Blood Pressure; Glucose Intolerance; Hypertension; Insulin Resistance; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1995 |
Spontaneously hypertensive rats are resistant to the development of hypercholesterolemia.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Blood Vessels; Cholesterol, Dietary; Disease Susceptibility; Fluorescein-5-isothiocyanate; Heart Rate; Hypercholesterolemia; Hypertension; Light; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Serum Albumin, Bovine; Vasodilation | 1995 |
Modulation by nitric oxide and prostaglandin of the renal vascular response to angiotensin II (3-8).
Topics: Angiotensin II; Animals; Cyclooxygenase Inhibitors; Drug Interactions; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Circulation; Vasoconstriction | 1996 |
The role of endogenous bradykinin in blood pressure homeostasis in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Bradykinin; Homeostasis; Hypertension; Male; NG-Nitroarginine Methyl Ester; Phentolamine; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1996 |
Pressure-dependent renin release during chronic blockade of nitric oxide synthase.
Topics: Animals; Antihypertensive Agents; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Pressure; Rats; Rats, Sprague-Dawley; Renin | 1996 |
Contribution of nitric oxide to the beneficial effects of enalapril in the fructose-induced hyperinsulinemic rat.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Drug Synergism; Enalapril; Fructose; Hyperinsulinism; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Triglycerides | 1996 |
Hypertension without cardiac hypertrophy does not induce a cardiac baroreflex deficit.
Topics: Animals; Baroreflex; Blood Pressure; Cardiomegaly; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar | 1996 |
Effects of methimazole in the early and established phases of NG-nitro-L-arginine methyl ester hypertension.
Topics: Administration, Oral; Animals; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Injections, Intravenous; Male; Methimazole; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Reference Values | 1996 |
Effect of antihypertensive treatment and N omega-nitro-L-arginine methyl ester on cardiovascular structure in deoxycorticosterone acetate-salt hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Body Weight; Calcium Channel Blockers; Cardiomegaly; Cilazapril; Desoxycorticosterone; Endothelin-1; Hypertension; NG-Nitroarginine Methyl Ester; Nifedipine; Organ Size; Rats; Rats, Sprague-Dawley; Renin | 1996 |
Effect of celiprolol therapy on arterial dilatation in experimental hypertension.
Topics: Acetylcholine; Adrenergic beta-Antagonists; Animals; Celiprolol; Cyclic AMP; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1996 |
[Contribution of the renin-angiotensin system to the variability of blood pressure in hypertensive rat after blockade of nitric oxide synthesis].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Heart Rate; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles | 1996 |
Vascular endothelin-1 gene expression and effect on blood pressure of chronic ETA endothelin receptor antagonism after nitric oxide synthase inhibition with L-NAME in normal rats.
Topics: Animals; Blood Pressure; Endothelin Receptor Antagonists; Endothelin-1; Gene Expression; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1997 |
Renal functional measurements in young rats with chronic inhibition of nitric oxide synthase.
Topics: Animals; Cholesterol; Creatinine; Enzyme Inhibitors; Guanidines; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Serum Albumin | 1996 |
Whey mineral supplementation and arterial tone in mineralocorticoid-NaCl hypertension.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Desoxycorticosterone; Diclofenac; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Milk; Minerals; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Potassium Chloride; Rats; Rats, Wistar; Sodium Chloride; Vascular Resistance; Vasodilator Agents | 1996 |
Nitric oxide (NO) modulates the neurogenic control of blood pressure in rats with chronic renal failure (CRF).
Topics: Angiotensin II; Animals; Aorta; Arginine; Blood Pressure; Brain; Creatinine; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Hypertension; Hypothalamus; Kidney Failure, Chronic; Locus Coeruleus; Male; Medulla Oblongata; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Norepinephrine; Paraventricular Hypothalamic Nucleus; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sympathetic Nervous System; Synaptic Transmission; Transcription, Genetic | 1997 |
Amplification of kinin-induced hypotension by nitric oxide synthesis in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Bradykinin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Hypotension; Injections, Intravenous; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phentolamine; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1997 |
Arthus C. Corcoran Memorial Lecture. Influence of nitric oxide and angiotensin II on renal involvement in hypertension.
Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Disease Models, Animal; Diuretics; Endothelium, Vascular; Humans; Hydrochlorothiazide; Hypertension; Kidney; Kidney Failure, Chronic; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Sodium Chloride Symporter Inhibitors | 1997 |
Temporal influence of the renal nerves on renal excretory function during chronic inhibition of nitric oxide synthesis.
Topics: Animals; Blood Pressure; Denervation; Dogs; Female; Heart Rate; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Sodium; Sympathetic Nervous System | 1997 |
Calcitonin gene-related peptide is a depressor in NG-nitro-L-arginine methyl ester-induced hypertension during pregnancy.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Female; Ganglia, Spinal; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Pregnancy; Pregnancy Complications, Cardiovascular; Rats; RNA, Messenger; RNA, Ribosomal, 18S | 1997 |
Reduced basal NO-mediated dilation and decreased endothelial NO-synthase expression in coronary vessels of spontaneously hypertensive rats.
Topics: Animals; Basal Metabolism; Bradykinin; Coronary Vessels; Drug Evaluation, Preclinical; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Perfusion; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1997 |
Blood pressure and vascular effects of endothelin blockade in chronic nitric oxide-deficient hypertension.
Topics: Animals; Blood Pressure; Bosentan; Drug Interactions; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred WKY; Sulfonamides; Vasoconstriction | 1997 |
Ramipril therapy improves arterial dilation in experimental hypertension.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Cyclooxygenase Inhibitors; Diclofenac; Endothelium, Vascular; Glyburide; Hypertension; In Vitro Techniques; Isoproterenol; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Potassium Channel Blockers; Ramipril; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1997 |
Role of nitric oxide in impaired coronary circulation and improvement by angiotensin II receptor antagonist in spontaneously hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Coronary Circulation; Enzyme Inhibitors; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetrazoles | 1995 |
Haemodynamic effects of NO-synthase inhibitors, NG-monomethyl-L-arginine, NG-nitro-L-arginine and NG-nitro-L-arginine methyl ester, and NO-donor, glyceryl trinitrate, in conscious SHRSP and WKY.
Topics: Animals; Blood Pressure; Cerebrovascular Disorders; Enzyme Inhibitors; Heart Rate; Hemodynamics; Hypertension; Microspheres; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Nitroglycerin; omega-N-Methylarginine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Regional Blood Flow; Vasodilator Agents | 1995 |
Mechanisms for preserved cerebrovascular autoregulation during hypertension in rats after sinoaortic denervation.
Topics: Animals; Cerebrovascular Circulation; Denervation; Enzyme Inhibitors; Hemodynamics; Homeostasis; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renal Circulation; Sinoatrial Node; Superior Cervical Ganglion; Vascular Resistance | 1995 |
Captopril prevents NO-deficient hypertension and left ventricular hypertrophy without affecting nitric oxide synthase activity in rats.
Topics: Administration, Oral; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Captopril; Disease Models, Animal; Enzyme Inhibitors; Evaluation Studies as Topic; Hypertension; Hypertrophy, Left Ventricular; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Time Factors | 1996 |
Restriction of nitric oxide rather than elevated blood pressure is responsible for alterations of vascular responses in nitric oxide-deficient hypertension.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Animals; Aorta; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Hypertension; Indomethacin; Isoproterenol; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Pulmonary Circulation; Rats; Rats, Wistar; Vasoconstriction; Vasodilation | 1996 |
Long-term inhibition of NO synthase induces cardiac hypertrophy with a decrease in adrenergic innervation.
Topics: Adrenergic Fibers; Animals; Blood Pressure; Enzyme Inhibitors; Heart; Heart Rate; Hypertension; Hypertrophy, Left Ventricular; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Rats; Rats, Wistar; Time Factors | 1996 |
Long-term NO synthase inhibition affects heart weight and geometry of coronary and carotid arteries.
Topics: Animals; Blood Pressure; Body Weight; Carotid Arteries; Coronary Vessels; Enzyme Inhibitors; Heart; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Rats; Rats, Wistar | 1996 |
Role of nitric oxide in lipopolysaccharide-induced mortality from spontaneously hypertensive rats.
Topics: Animals; Aorta, Thoracic; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Escherichia coli; Guanidines; Hypertension; Lipopolysaccharides; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Survival Rate | 1997 |
Physostigmine and modulators of nitric oxide system on the mean arterial pressure of the spontaneously hypertensive rat.
Topics: Animals; Arginine; Blood Pressure; Cholinesterase Inhibitors; Drug Interactions; Enzyme Inhibitors; Female; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Physostigmine; Rats; Rats, Inbred SHR | 1997 |
Endothelium-dependent vascular responses in 1,3-dipropyl-8-sulphophenylxanthine (DPSPX) hypertensive rats.
Topics: Animals; Blood Pressure; Carbachol; Endothelium, Vascular; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitroprusside; Norepinephrine; Rats; Rats, Wistar; Vasodilation; Xanthines | 1997 |
Progesterone up-regulates vasodilator effects of calcitonin gene-related peptide in N(G)-nitro-L-arginine methyl ester-induced hypertension.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Drug Interactions; Female; Hypertension; NG-Nitroarginine Methyl Ester; Pregnancy; Pregnancy Complications, Cardiovascular; Progesterone; Puerperal Disorders; Rats; Rats, Sprague-Dawley; Up-Regulation; Vasodilation | 1997 |
Nitric oxide synthase inhibition by N(omega)-nitro-L-arginine methyl ester modulates G-protein expression and adenylyl cyclase activity in rat heart.
Topics: Adenylyl Cyclases; Animals; Enzyme Inhibitors; GTP-Binding Proteins; Heart; Hypertension; Myocardium; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley | 1997 |
Cerebrovascular effects of nitric oxide manipulation in spontaneously hypertensive rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipyrine; Autoradiography; Blood Pressure; Cerebrovascular Circulation; Disease Models, Animal; Hypertension; Indazoles; Infusions, Intravenous; Injections, Intravenous; Isotope Labeling; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 1997 |
Nitric oxide synthase inhibition with N omega-nitro-L-arginine methyl ester affects blood pressure and cardiovascular structure in the genetically hypertensive rat strain.
Topics: Animals; Blood Pressure; Endothelium, Vascular; Hypertension; Hypertrophy, Left Ventricular; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Mutant Strains; Rats, Wistar; Vascular Resistance | 1997 |
Effects of polymerization on the hypertensive action of diaspirin cross-linked hemoglobin in rats.
Topics: Analysis of Variance; Animals; Aorta; Aspirin; Blood Pressure; Blood Substitutes; Cardiac Output; Cross-Linking Reagents; Endothelium, Vascular; Enzyme Induction; Glomerular Filtration Rate; Heart Rate; Hemodynamics; Hemoglobins; Humans; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Polyethylene Glycols; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Stroke Volume; Vascular Resistance | 1997 |
Comparison of the nitric oxide and cyclo-oxygenase pathway in mesenteric resistance vessels of normotensive and spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Blood Pressure; Cholic Acids; Hypertension; Male; Mefenamic Acid; Mesenteric Arteries; Mesenteric Veins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Chloride; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1997 |
Estrogen effects on nitric oxide release.
Topics: Animals; Enzyme Inhibitors; Estrogens; Female; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rabbits; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1997 |
Effect of acute N-nitro-L-arginine methyl ester (L-NAME) hypertension on glucose tolerance, insulin levels, and [3H]-deoxyglucose muscle uptake.
Topics: Animals; Deoxyglucose; Glucose; Glucose Tolerance Test; Hypertension; Insulin; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley | 1997 |
Endothelial dysfunction in spontaneously hypertensive rats: consequences of chronic treatment with losartan or captopril.
Topics: Acetylcholine; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Captopril; Endothelium, Vascular; Hypertension; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Superoxide Dismutase; Tetrazoles; Vasoconstriction; Vasodilation | 1997 |
The sympathetic nervous system is involved in the maintenance but not initiation of the hypertension induced by N(omega)-nitro-L-arginine methyl ester.
Topics: Analysis of Variance; Animals; Endothelin-1; Guanethidine; Hypertension; Longitudinal Studies; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Sympathectomy, Chemical; Sympathetic Nervous System; Time Factors | 1997 |
Nitric oxide, the kidney and hypertension.
Topics: Animals; Dogs; Enzyme Inhibitors; Glomerular Filtration Rate; Hypertension; Kidney; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide | 1997 |
Cardiovascular effects of chronic inhibition of nitric oxide synthesis and dietary salt in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Creatinine; Enzyme Inhibitors; Hemodynamics; Hypertension; In Vitro Techniques; Kidney; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Proteinuria; Rats; Rats, Inbred SHR; Renin; Sodium Chloride, Dietary; Weight Gain | 1997 |
Nitric oxide and vascular reactivity in pregnant rats with adriamycin nephropathy.
Topics: Acetylcholine; Animals; Antibiotics, Antineoplastic; Arginine; Doxorubicin; Female; Hypertension; In Vitro Techniques; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Pregnancy; Pregnancy Complications, Cardiovascular; Rats; Rats, Wistar; Vasoconstriction | 1997 |
The role of nitric oxide in the control of plasma glucose concentration in spontaneously hypertensive rats.
Topics: Animals; Blood Glucose; Enzyme Inhibitors; Homeostasis; Hypertension; Insulin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1997 |
Arterial function in mineralocorticoid-NaCl hypertension: influence of angiotensin-converting enzyme inhibition.
Topics: Acetylcholine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; Isoquinolines; Male; Mesenteric Arteries; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Quinapril; Rats; Rats, Inbred WKY; Sodium Chloride; Tetrahydroisoquinolines | 1997 |
Endogenous nitric oxide on arterial hemodynamics: a comparison between normotensive and hypertensive rats.
Topics: Animals; Arteries; Blood Pressure; Enzyme Inhibitors; Heart Rate; Hemodynamics; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pulse; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Vascular Resistance | 1997 |
[Contribution of L-arginine-derived nitric oxide to the structural integrity of coronary artery and cardiac interstitium, and to the regulation of sympathetic nerve activity: assessment using a rat model produced by chronic nitric oxide inhibition].
Topics: Animals; Arginine; Catecholamines; Chronic Disease; Coronary Vessels; Disease Models, Animal; Fibrosis; Heart Rate; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Renin; Sympathetic Nervous System | 1997 |
Difference in susceptibility of developing renal damage in normotensive fawn-hooded (FHL) and August x Copenhagen Irish (ACI) rats after N(omega)-nitro-L-arginine methyl ester induced hypertension.
Topics: Albuminuria; Animals; Disease Susceptibility; Enzyme Inhibitors; Hypertension; Kidney; Kidney Diseases; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred ACI; Regression Analysis; Species Specificity | 1997 |
[Mechanism mediating hypertension induced by chronic inhibition of nitric oxide synthesis].
Topics: Animals; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium; Rats; Rats, Sprague-Dawley; Sodium; Sodium, Dietary; Sympathetic Nervous System | 1997 |
Sex differences in the abundance of endothelial nitric oxide in a model of genetic hypertension.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Body Weight; Carbachol; Cerebrovascular Disorders; Ditiocarb; Endothelium, Vascular; Female; Humans; Hypertension; In Vitro Techniques; Indomethacin; Isometric Contraction; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sex Characteristics; Systole | 1997 |
Investigation of the inhibitory effect of N(G)-nitro-L-arginine methyl ester on the antihypertensive effect of the angiotensin AT1 receptor antagonist, GR138950.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Benzofurans; Blood Pressure; Cyclic GMP; Drug Interactions; Enalapril; Enzyme Inhibitors; Hydralazine; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phosphodiesterase Inhibitors; Purinones; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1997 |
Dietary calcium decreases blood pressure without decreasing renal vascular resistance or altering the response to NO blockade.
Topics: Age Factors; Animals; Blood Pressure; Calcium, Dietary; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Rats; Rats, Inbred SHR; Regional Blood Flow; Vascular Resistance | 1997 |
Evolution of chronic nitric oxide inhibition hypertension: relationship to renal function.
Topics: Animals; Blood Pressure; Blood Volume; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Vascular Resistance | 1998 |
AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Cerebrovascular Disorders; Cyclic GMP; Hypertension; Imidazoles; Losartan; Male; Minoxidil; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Pyridines; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values | 1998 |
Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo.
Topics: Actins; Aldosterone; Animals; Aorta, Thoracic; Carbachol; Cardiomegaly; Cell Cycle; DNA; Heart; Hypertension; In Vitro Techniques; Isometric Contraction; Muscle, Skeletal; Muscle, Smooth, Vascular; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Polyploidy; Rats; Rats, Inbred WKY; Renin-Angiotensin System; RNA, Messenger; Transcription, Genetic | 1998 |
Systemic inhibition of nitric oxide and prostaglandins in volume-induced natriuresis and hypertension.
Topics: Animals; Blood Pressure; Body Weight; Cyclooxygenase Inhibitors; Diuresis; Dogs; Drug Interactions; Female; Glomerular Filtration Rate; Hemodynamics; Hypertension; Male; Meclofenamic Acid; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Renal Circulation; Saline Solution, Hypertonic | 1998 |
Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis.
Topics: Animals; Blood Pressure; Garlic; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitrites; Plants, Medicinal; Rats; Rats, Wistar | 1998 |
[The stereology of the myocardium in rats hypertensive due to the use of an inhibitor of nitric oxide synthesis].
Topics: Animals; Enzyme Inhibitors; Heart; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Statistics, Nonparametric | 1997 |
Losartan reduces constrictor responses to endothelin-1 and the thromboxane A2 analogue in aortic rings from spontaneously hypertensive rats: role of nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Aorta, Thoracic; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents | 1997 |
Cellular changes induced by chronic nitric oxide inhibition in intact rat basilar arteries revealed by confocal microscopy.
Topics: Animals; Basilar Artery; Cell Count; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Microscopy, Confocal; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred WKY | 1997 |
Renoprotective effects of felodipine and/or enalapril in spontaneously hypertensive rats with and without L-NAME.
Topics: Animals; Antihypertensive Agents; Arterioles; Drug Therapy, Combination; Enalapril; Enzyme Inhibitors; Felodipine; Glomerular Filtration Rate; Hemodynamics; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Organ Size; Rats; Rats, Inbred SHR; Vasodilator Agents | 1998 |
Participation of kinins in the inhibitory action of captopril on acute hypertension induced by L-NAME in anesthetized rats.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Captopril; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar | 1997 |
Inhibition of nitric oxide synthase causes profound enhancement of the Bezold-Jarisch reflex.
Topics: Animals; Blood Pressure; Bradycardia; Depression, Chemical; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Reflex; Serotonin | 1998 |
Sympathetic functions in NG-nitro-L-arginine-methyl-ester-induced hypertension: modulation by the renin-angiotensin system.
Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Enalaprilat; Enzyme Inhibitors; Epinephrine; GTP-Binding Proteins; Heart; Hemodynamics; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Renin-Angiotensin System; Sympathetic Nervous System | 1998 |
Effect of a nitric oxide-releasing naproxen derivative on hypertension and gastric damage induced by chronic nitric oxide inhibition in the rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Gastric Mucosa; Hypertension; Male; Naproxen; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Stomach Ulcer; Thromboxane B2 | 1998 |
Endothelin-1 gene expression in blood vessels and kidney of spontaneously hypertensive rats (SHR), L-NAME-treated SHR, and renovascular hypertensive rats.
Topics: Animals; Blood Vessels; Endothelin-1; Endothelins; Enzyme Inhibitors; Gene Expression Regulation; Hypertension; Hypertension, Renovascular; In Situ Hybridization; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Protein Precursors; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1998 |
Role of endothelin ET(A) receptors in the hypertension produced by 4-day L-nitroarginine methyl ester and cyclosporine treatment.
Topics: Animals; Atrasentan; Cyclosporine; Drinking Behavior; Endothelin Receptor Antagonists; Enzyme Inhibitors; Feeding Behavior; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptors, Endothelin | 1998 |
Nitric oxide inhibition induces early activation of type I collagen gene in renal resistance vessels and glomeruli in transgenic mice. Role of endothelin.
Topics: Animals; Collagen; Endothelium, Vascular; Enzyme Inhibitors; Extracellular Matrix; Gene Expression Regulation; Hypertension; Kidney; Kidney Glomerulus; Luciferases; Mice; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Renal Circulation; Transcriptional Activation; Vascular Resistance | 1998 |
The contribution of nitric oxide to cardiovascular status and responses to vasodilators in conscious, hypertensive, transgenic ((mRen-2)27) rats.
Topics: Acetylcholine; Adrenergic beta-Agonists; Albuterol; Animals; Animals, Genetically Modified; Antihypertensive Agents; Blood Pressure; Bradykinin; Female; Hindlimb; Hypertension; Kidney; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Vasodilation; Vasodilator Agents | 1998 |
Evaluation of the renin-angiotensin system in a congenic renin Dahl salt-sensitive rat.
Topics: Adrenal Glands; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Enzyme Inhibitors; Hypertension; Kidney; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred Strains; Renin; Renin-Angiotensin System; RNA, Messenger; Saralasin; Sodium | 1997 |
Influence of gender on control of arterial tone in experimental hypertension.
Topics: Acetylcholine; Adenosine Diphosphate; Adrenergic beta-Agonists; Animals; Apamin; Blood Pressure; Calcium; Diclofenac; Disease Progression; Endothelium, Vascular; Female; Hypertension; In Vitro Techniques; Isoproterenol; Male; Mesenteric Artery, Superior; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Serotonin; Sex Characteristics; Vasoconstriction | 1998 |
Left ventricular adaptation to chronic pressure overload induced by inhibition of nitric oxide synthase in rats.
Topics: Adaptation, Physiological; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Follow-Up Studies; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Lisinopril; Male; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Random Allocation; Rats; Rats, Wistar; Ventricular Pressure | 1998 |
Effects of L-NAME and L-Arg on arterial blood pressure in normotensive and hypertensive streptozotocin diabetic rats.
Topics: Analysis of Variance; Animals; Arginine; Blood Pressure; Diabetes Mellitus, Experimental; Endothelium, Vascular; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Streptozocin | 1998 |
[Morphology and stereology of the myocardium in hypertensive rats. Correlation with the time of nitric oxide synthesis inhibition].
Topics: Animals; Enzyme Inhibitors; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Rats; Rats, Wistar; Time Factors | 1998 |
Heme oxygenase-1-derived carbon monoxide contributes to the suppression of acute hypertensive responses in vivo.
Topics: Acute Disease; Animals; Blood Pressure; Carbon Monoxide; Depression, Chemical; Enzyme Inhibitors; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hemoglobins; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Postoperative Complications; Rats; Rats, Sprague-Dawley; Stress, Physiological; Up-Regulation | 1998 |
[Renal alterations in L-NAME hypertension: influence of losartan and bosentan].
Topics: Albuminuria; Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hemodynamics; Hypertension; Kidney; Kidney Function Tests; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Sulfonamides | 1998 |
Chronic hypertension leads to hyperinsulinemia in Sprague-Dawley rats treated with nitric oxide synthase inhibitor.
Topics: Animals; Blood Pressure; Hyperinsulinism; Hypertension; Insulin Resistance; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1998 |
Hypertensive response to chronic NO synthase inhibition is different in Sprague-Dawley rats from two suppliers.
Topics: Animals; Enzyme Inhibitors; Genetic Variation; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Species Specificity | 1998 |
Central and peripheral mechanisms involved in hypertension induced by chronic inhibition of nitric oxide synthase in rats.
Topics: Acute Disease; Adrenergic alpha-Antagonists; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Chronic Disease; Denervation; Enzyme Inhibitors; Hypertension; Injections, Intravenous; Injections, Intraventricular; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phentolamine; Rats; Rats, Wistar; Sinoatrial Node; Tetrazoles | 1998 |
Stereology of the myocardium in hypertensive rats. Differences in relation to the time of inhibition of nitric oxide synthesis.
Topics: Animals; Blood Pressure; Cell Count; Coronary Vessels; Disease Models, Animal; Enzyme Inhibitors; Heart; Hypertension; Male; Microscopy, Video; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Rats; Rats, Wistar; Time Factors | 1998 |
Pre-eclamptic toxemia: potential new therapy based on animal studies.
Topics: Animals; Blood Pressure; Calcitonin Gene-Related Peptide; Disease Models, Animal; Drug Therapy, Combination; Embryonic and Fetal Development; Female; Hemodynamics; Hypertension; NG-Nitroarginine Methyl Ester; Postpartum Period; Pre-Eclampsia; Pregnancy; Progesterone; Rats; Rats, Sprague-Dawley; Survival Rate | 1998 |
Alterations in the vasoreactivity of hypertensive rat aortic rings: role of nitric oxide and superoxide radicals.
Topics: Acetylcholine; Animals; Aorta; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Superoxides; Vasoconstrictor Agents; Vasodilator Agents; Vasomotor System | 1998 |
Involvement of nitric oxide and potassium channels in the reduction of basal tone produced by blockade of thromboxane A2/prostaglandin H2 receptors in aortic rings of hypertensive rats.
Topics: 4-Aminopyridine; Animals; Aorta; Basal Metabolism; Bridged Bicyclo Compounds, Heterocyclic; Hypertension; Male; Muscle Tonus; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxazoles; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Prostaglandin; Receptors, Thromboxane; Receptors, Thromboxane A2, Prostaglandin H2; Tetraethylammonium; Vasodilator Agents | 1998 |
Differences in responses to norepinephrine and adenosine triphosphate in isolated, perfused mesenteric vascular beds between normotensive and spontaneously hypertensive rats.
Topics: Adenosine Triphosphate; Animals; Hypertension; Indomethacin; Male; Mesenteric Arteries; Mesenteric Veins; NG-Nitroarginine Methyl Ester; Norepinephrine; Perfusion; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Receptors, Purinergic P2 | 1998 |
Role of nitric oxide in vascular hyper-responsiveness to norepinephrine in hypertensive Dahl rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Hypertrophy; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Norepinephrine; Rats; Rats, Inbred Dahl; Sodium, Dietary; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 1998 |
Chronic blockade of endothelin ETA receptors improves flow dependent dilation in resistance arteries of hypertensive rats.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelin Receptor Antagonists; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Indomethacin; Male; Mesenteric Arteries; Muscle Contraction; NG-Nitroarginine Methyl Ester; Phenylephrine; Phenylpropionates; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin A; Regional Blood Flow; Stress, Mechanical; Vasoconstrictor Agents; Vasodilation | 1998 |
Hydralazine prevents endothelial dysfunction, but not the increase in superoxide production in nitric oxide-deficient hypertension.
Topics: Acetylcholine; Animals; Blood Pressure; Blotting, Western; Ditiocarb; Endothelium, Vascular; Female; Guanylate Cyclase; Hydralazine; Hypertension; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Superoxide Dismutase; Superoxides | 1998 |
The contribution of nitric oxide to renal vascular wall thickening in rats with L-NAME-induced hypertension.
Topics: Actins; Animals; Apolipoproteins B; Arteries; Blood Pressure; Cholesterol; Fibronectins; Hypertension; Kidney; Male; Microscopy, Fluorescence; Microscopy, Immunoelectron; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrogen Compounds; Rats; Rats, Sprague-Dawley; Regression Analysis | 1998 |
Stereology and immunohistochemistry of the myocardium in experimental hypertension: long-term and low-dosage administration of inhibitor of the nitric oxide synthesis.
Topics: Animals; Cell Count; Collagen; Disease Models, Animal; Enzyme Inhibitors; Fibronectins; Hypertension; Immunohistochemistry; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Time Factors | 1999 |
Streptozotocin-induced diabetes enhances protective effects of enalapril on nitric oxide-deficient stroke in stroke-prone rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Cerebrovascular Disorders; Diabetes Mellitus, Experimental; Enalapril; Endothelin-1; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Streptozocin; Weight Gain | 1998 |
ET(A) receptor antagonist ameliorates nephrosclerosis and left ventricular hypertrophy induced in rat by prolonged inhibition of nitric oxide synthesis.
Topics: Albuminuria; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Drug Combinations; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hypertension; Hypertrophy, Left Ventricular; Imidazoles; Imidazolidines; Male; Nephrosclerosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptor, Endothelin A; Time Factors | 1998 |
Pressure natriuresis in nitric oxide-deficient hypertensive rats: effect of antihypertensive treatments.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Calcium Channel Blockers; Captopril; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Tetrazoles; Verapamil | 1999 |
Comparison of the effects of supplementation with whey mineral and potassium on arterial tone in experimental hypertension.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Cyclooxygenase Inhibitors; Dietary Supplements; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Minerals; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Potassium; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Tetraethylammonium; Vasoconstriction; Vasodilator Agents | 1998 |
Role of NO and angiotensin II in the early development of endothelial functions impairment and cardiac hypertrophy in deoxycorticosterone acetate-salt hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cardiomegaly; Desoxycorticosterone; Endothelium, Vascular; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Rats; Rats, Sprague-Dawley; Sodium Chloride; Splanchnic Circulation | 1998 |
Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cardiomegaly; Cell Nucleus; Diastole; DNA; Female; Heart Rate; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Indoles; Losartan; Lymphocytes; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Perindopril; Rats; Rats, Inbred SHR; Systole; Telemetry; Time Factors | 1999 |
Local renal medullary L-NAME infusion enhances the effect of long-term angiotensin II treatment.
Topics: Angiotensin II; Animals; Blood Pressure; Drug Synergism; Hypertension; Infusions, Intravenous; Infusions, Parenteral; Kidney Cortex; Kidney Medulla; Nephrectomy; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Regional Blood Flow; Renal Circulation; Time Factors | 1999 |
Effects of vasodilatory beta-adrenoceptor antagonists on endothelium-derived nitric oxide release in rat kidney.
Topics: Adrenergic beta-Antagonists; Animals; Aorta, Thoracic; Benzopyrans; Celiprolol; Desoxycorticosterone; Dose-Response Relationship, Drug; Endothelium, Vascular; Ethanolamines; Hypertension; In Vitro Techniques; Kidney; Male; Metergoline; Muscle, Smooth, Vascular; Nebivolol; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylephrine; Pindolol; Piperazines; Piperidines; Platelet Aggregation Inhibitors; Quinazolines; Rats; Rats, Wistar; Renal Circulation; Serotonin Antagonists; Vasoconstriction; Vasodilator Agents | 1999 |
Comparison of the vascular relaxant effects of ATP-dependent K+ channel openers on aorta and pulmonary artery isolated from spontaneously hypertensive and Wistar-Kyoto rats.
Topics: Adenosine Triphosphate; Aminoquinolines; Animals; Aorta, Thoracic; Apamin; Benzopyrans; Charybdotoxin; Cromakalim; Dose-Response Relationship, Drug; Glyburide; Hypertension; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nicorandil; Nitroprusside; Norepinephrine; Picolines; Pinacidil; Potassium; Potassium Channels; Pulmonary Artery; Pyrans; Pyrrolidinones; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 1999 |
Streptozotocin diabetes in the pregnant rat induces cardiovascular dysfunction in adult offspring.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Cardiovascular Diseases; Diabetes Mellitus, Experimental; Female; Heart Rate; Hypertension; In Vitro Techniques; Indomethacin; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitroprusside; Norepinephrine; Pregnancy; Pregnancy in Diabetics; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Vasoconstriction; Vasodilation | 1999 |
Role of iNOS in the vasodilator responses induced by L-arginine in the middle cerebral artery from normotensive and hypertensive rats.
Topics: Animals; Anti-Bacterial Agents; Arginine; Cerebral Arteries; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprost; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Glucocorticoids; Hypertension; In Vitro Techniques; Indomethacin; Lipopolysaccharides; Male; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Polymyxin B; Protein Kinase C; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity; Superoxide Dismutase; Vasodilation | 1999 |
Effects of antihypertensive therapy on factors mediating endothelium-dependent relaxation in rats treated chronically with L-NAME.
Topics: Acetylcholine; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Chronic Disease; Diltiazem; Disease Models, Animal; Endothelium, Vascular; Hypertension; Isoquinolines; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Quinapril; Rats; Rats, Sprague-Dawley; Tetrahydroisoquinolines; Treatment Outcome; Vasodilation; Vasodilator Agents | 1999 |
Effect of endothelin blockade on pressure natriuresis in nitric oxide-deficient hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Flow Velocity; Blood Pressure; Bosentan; Diuresis; Endothelins; Enzyme Inhibitors; Glomerular Filtration Rate; Hypertension; Kidney; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Sulfonamides | 1999 |
Antihypertensive effect of insulin via nitric oxide production in the Zucker diabetic fatty rat, an animal model for non-insulin-dependent diabetes mellitus.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Glucose; Blood Pressure; Diabetes Mellitus, Type 2; Enzyme Activation; Enzyme Inhibitors; Histocytochemistry; Humans; Hypertension; In Vitro Techniques; Insulin; Male; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Zucker; Recombinant Proteins | 1999 |
Losartan and enalapril therapies enhance vasodilatation in the mesenteric artery of spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Diclofenac; Enalapril; Endothelium; Enzyme Inhibitors; Heart Rate; Hypertension; In Vitro Techniques; Losartan; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstrictor Agents; Vasodilation | 1999 |
Renal effects of an acute NaCl load in chronic nitric oxide blockade-induced hypertensive rats.
Topics: Animals; Blood Pressure; Body Weight; Enzyme Inhibitors; Glomerular Filtration Rate; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sodium; Sodium Chloride | 1998 |
Myocardial microcirculation stereological changes in rats subjected to nitric oxide synthesis inhibition.
Topics: Animals; Coronary Circulation; Enzyme Inhibitors; Hypertension; Male; Microcirculation; Microscopy, Video; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 1999 |
Impaired nitric oxide-independent dilation of renal afferent arterioles in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Arterioles; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Insulin; Kidney; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renal Artery; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 1999 |
Influence of age on inotropic response to insulin and insulin-like growth factor I in spontaneously hypertensive rats: role of nitric oxide.
Topics: Aging; Animals; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Male; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Papillary Muscles; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1999 |
Higher level of plasma nitric oxide in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Enzyme Inhibitors; Hypertension; Lipopolysaccharides; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 1999 |
Adrenomedullin attenuates the hypertension in hypertensive pregnant rats induced by N(G)-nitro-L-arginine methyl ester.
Topics: Adrenomedullin; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Northern; Body Weight; Disease Models, Animal; Enzyme Inhibitors; Female; Fetus; Hypertension; Infusions, Intravenous; NG-Nitroarginine Methyl Ester; Peptides; Pre-Eclampsia; Pregnancy; Pregnancy, Animal; Rats; Rats, Wistar; RNA, Messenger; Time Factors | 1999 |
Endothelial dysfunction in the aorta of transgenic rats harboring the mouse Ren-2 gene.
Topics: Acetylcholine; Angiotensin II; Animals; Animals, Genetically Modified; Aorta; Blood Pressure; Body Weight; Endothelin-1; Endothelins; Endothelium, Vascular; Hypertension; Male; Mice; Muscle Contraction; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Norepinephrine; Protein Precursors; Rats; Rats, Sprague-Dawley; Renin | 1999 |
Enhanced nitric oxide synthesis reverses salt-induced alterations in blood flow and cGMP levels.
Topics: Animals; Aorta, Abdominal; Arginine; Blood Flow Velocity; Blood Pressure; Cyclic GMP; Eicosapentaenoic Acid; Enzyme Inhibitors; Heart Rate; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Radioimmunoassay; Random Allocation; Rats; Rats, Inbred Dahl; Renal Artery; Sodium, Dietary | 1999 |
[Experimental anatomo-pathologic study in the myocardium of animals with arterial hypertension caused via a nitric oxide synthesis blocker].
Topics: Animals; Enzyme Inhibitors; Fibrosis; Heart Atria; Heart Ventricles; Hypertension; Myocardial Infarction; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Time Factors | 1999 |
Impaired flow-dependent dilatation in distal mesenteric arteries from the spontaneously hypertensive rat.
Topics: Animals; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Splanchnic Circulation; Vasodilation | 1999 |
Nitric oxide-dependent renal vasodilatation is not altered in rat with rHuEpo-induced hypertension.
Topics: Animals; Creatinine; Enzyme Inhibitors; Erythropoietin; Humans; Hypertension; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Perfusion; Rats; Rats, Wistar; Recombinant Proteins; Renal Circulation; Vasodilation; Vasodilator Agents | 1999 |
Aortic connexin43 is decreased during hypertension induced by inhibition of nitric oxide synthase.
Topics: Animals; Aorta; Cardiomegaly; Carotid Arteries; Connexin 43; Enzyme Inhibitors; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphorylation; Rats; Rats, Inbred WKY | 1999 |
Impaired endothelium-dependent relaxation in mesenteric arteries of reduced renal mass hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Apamin; Biological Factors; Blood Pressure; Diazoxide; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Kidney; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Potassium; Potassium Channels; Rats; Rats, Wistar; Vasodilation; Vasodilator Agents | 1999 |
Effect of Ca2+ channel blockers on arterial hypertension and heart ischaemic lesions induced by chronic blockade of nitric oxide in the rat.
Topics: Animals; Blood Pressure; Blood Pressure Determination; Body Weight; Calcium Channel Blockers; Diltiazem; Enzyme Inhibitors; Heart Ventricles; Hypertension; Male; Myocardial Ischemia; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Rats; Rats, Wistar; Survival Analysis | 1999 |
Protein expression, vascular reactivity and soluble guanylate cyclase activity in mice lacking the endothelial cell nitric oxide synthase: contributions of NOS isoforms to blood pressure and heart rate control.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Blotting, Western; Enzyme Inhibitors; Gene Deletion; Gene Expression; Guanylate Cyclase; Heart Rate; Hemodynamics; Heterozygote; Hypertension; In Vitro Techniques; Isoenzymes; Mice; Mice, Inbred C57BL; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Vasoconstriction | 1999 |
Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition.
Topics: Amidines; Animals; Benzylamines; Drug Resistance; Enzyme Inhibitors; Female; Hypertension; Male; Microscopy, Video; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Dahl; Sodium Chloride; Thiazines; Urea | 1999 |
Effects of amlodipine on nitric oxide synthase mRNA expression and coronary microcirculation in prolonged nitric oxide blockade-induced hypertensive rats.
Topics: Amlodipine; Animals; Calcium Channel Blockers; Coronary Circulation; Hemodynamics; Hypertension; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; RNA, Messenger | 1999 |
Differential effects of T- and L-type calcium antagonists on glomerular dynamics in spontaneously hypertensive rats.
Topics: Amlodipine; Animals; Antihypertensive Agents; Benzimidazoles; Calcium Channel Blockers; Calcium Channels; Creatinine; Data Interpretation, Statistical; Enzyme Inhibitors; Glomerular Filtration Rate; Heart; Hemodynamics; Hypertension; Kidney; Kidney Glomerulus; Kidney Tubules; Male; Mibefradil; Nephrocalcinosis; NG-Nitroarginine Methyl Ester; Organ Size; Rats; Rats, Inbred SHR; Tetrahydronaphthalenes; Uric Acid; Vasodilator Agents | 1999 |
Prolonged blockade of endothelin ET(A) receptors decreases vascular reactivity in the aorta of spontaneously hypertensive rats in vitro.
Topics: Acetylcholine; Animals; Aorta; Biological Factors; Blood Pressure; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Phenylpropionates; Pyrimidines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Endothelin A; Receptors, Endothelin; Vasoconstriction; Vasodilation | 1999 |
Chronic endothelin-1 improves nitric oxide-dependent flow-induced dilation in resistance arteries from normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Cyclooxygenase Inhibitors; Endothelin-1; Enzyme Inhibitors; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pressure; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reference Values; Regional Blood Flow; Stress, Mechanical; Time Factors; Vascular Resistance; Vasodilation | 1999 |
The effect of an endothelin antagonist on blood pressure in a rat model of preeclampsia.
Topics: Animals; Blood Pressure; Disease Models, Animal; Endothelins; Enzyme Inhibitors; Female; Gestational Age; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptides, Cyclic; Pre-Eclampsia; Pregnancy; Rats; Rats, Sprague-Dawley | 1999 |
Arterial relaxation mediated by endothelium-derived hyperpolarizing factor in hypertension induced by chronic inhibition of nitric oxide synthesis.
Topics: Acetylcholine; Animals; Apamin; Biological Factors; Blood Pressure; Disease Models, Animal; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Phenylephrine; Potassium; Potassium Channels; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 1999 |
Apoptosis, coronary arterial remodeling, and myocardial infarction after nitric oxide inhibition in SHR.
Topics: Animals; Apoptosis; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Fibrosis; Hemodynamics; Hypertension; Male; Myocardial Infarction; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR | 1999 |
Rostral ventrolateral medulla : A source of sympathetic activation in rats subjected to long-term treatment with L-NAME.
Topics: Animals; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Glycine; Hypertension; Kynurenic Acid; Male; Medulla Oblongata; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Sympathetic Nervous System | 1999 |
Exercise reverses peripheral insulin resistance in trained L-NAME-hypertensive rats.
Topics: Animals; Hypertension; Insulin Resistance; Male; NG-Nitroarginine Methyl Ester; Physical Conditioning, Animal; Pressoreceptors; Rats; Rats, Wistar; Sympathetic Nervous System | 1999 |
Ca(2+)-insensitive vascular protein kinase C during pregnancy and NOS inhibition.
Topics: Animals; Calcium; Enzyme Inhibitors; Female; Hypertension; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pregnancy; Pregnancy Complications, Cardiovascular; Pregnancy, Animal; Protein Kinase C; Rats; Rats, Sprague-Dawley; Staurosporine; Vascular Resistance | 1999 |
Mibefradil prevents L-NAME-exacerbated nephrosclerosis in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Drug Antagonism; Enzyme Inhibitors; Hypertension; Mibefradil; Nephrosclerosis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR | 1999 |
Arterial function in nitric oxide-deficient hypertension: influence of long-term angiotensin II receptor antagonism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cromakalim; Cyclooxygenase Inhibitors; Diclofenac; Hypertension; In Vitro Techniques; Isoproterenol; Losartan; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents | 1999 |
Effect of captopril in L-NAME-induced hypertension on the rat myocardium, aorta, brain and kidney.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Blood Pressure; Body Weight; Brain; Captopril; Cyclic GMP; DNA; Heart Rate; Hypertension; Kidney; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Protein Biosynthesis; Rats; Rats, Wistar; RNA | 1999 |
Chronic nitric oxide inhibition model six years on.
Topics: Humans; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide | 1999 |
Influence of circadian time, ageing, and hypertension on the urinary excretion of nitric oxide metabolites in rats.
Topics: Aging; Animals; Creatinine; Diuresis; Drinking; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrites; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors | 1999 |
Cardiovascular responses to angiotensins I and II in normotensive and hypertensive rats; effects of NO synthase inhibition or ET receptor antagonism.
Topics: Angiotensin I; Angiotensin II; Animals; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hemodynamics; Hypertension; Indans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Vasoconstrictor Agents | 1999 |
Modelling the changes due to the endothelium and hypertension in the alpha-adrenoreceptor-mediated responses of rat aorta.
Topics: Adrenergic alpha-Agonists; Algorithms; Animals; Aorta, Thoracic; Carotid Arteries; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha; Receptors, Adrenergic, alpha-1; Vasoconstriction | 1999 |
Role of glutathione in stabilization of nitric oxide during hypertension developed by inhibition of nitric oxide synthase in the rat.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Glutathione; Hypertension; Kidney; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Rats; Rats, Wistar | 1999 |
Influence of age on contractile response to insulin-like growth factor 1 in ventricular myocytes from spontaneously hypertensive rats.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Aging; Animals; Body Weight; Calcium; Calcium Channel Agonists; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Ventricles; Hypertension; Insulin-Like Growth Factor I; Intracellular Fluid; Kidney; Liver; Male; Microscopy, Fluorescence; Muscle Contraction; NG-Nitroarginine Methyl Ester; Organ Size; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Ventricular Dysfunction | 1999 |
Blood pressure variability in established L-NAME hypertension in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Prazosin; Rats; Rats, Wistar; Time Factors | 1999 |
Exercise enhances vasorelaxation in experimental obesity associated hypertension.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Analysis of Variance; Animals; Blood Glucose; Carotid Arteries; Cholesterol; Cyclooxygenase Inhibitors; Diclofenac; Endothelium, Vascular; Hypertension; In Vitro Techniques; Insulin; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Obesity; Physical Exertion; Rats; Rats, Zucker; Thromboxane B2; Triglycerides; Vasodilation; Vasodilator Agents | 1999 |
Corticotrophin releasing factor attenuates NG-nitro-L-arginine methyl ester induced increases in blood pressure in the anaesthetised rat.
Topics: Anesthesia; Animals; Corticotropin-Releasing Hormone; Disease Models, Animal; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Reference Values; Vasodilation | 1999 |
Calcium-mediated mechanisms of eicosapentaenoic acid-induced relaxation in hypertensive rat aorta.
Topics: Angiotensin II; Animals; Aorta, Thoracic; Blood Pressure; Calcium; Cells, Cultured; Eicosapentaenoic Acid; Endothelium, Vascular; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Hypertension; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Norepinephrine; Potassium Channels; Rats; Rats, Inbred SHR; Vasoconstrictor Agents; Vasodilation | 1999 |
Inhibition of nitric oxide synthase induces renal xanthine oxidoreductase activity in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Enzyme Inhibitors; Hypertension; Isosorbide Dinitrate; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Sodium Chloride, Dietary; Xanthine Dehydrogenase; Xanthine Oxidase | 1999 |
L-NAME-induced protein remodeling and fibrosis in the rat heart.
Topics: Animals; Blood Pressure; Collagen; Cyclic GMP; Dose-Response Relationship, Drug; Endomyocardial Fibrosis; Enzyme Inhibitors; Heart; Heart Rate; Heart Ventricles; Hydroxyproline; Hypertension; Immunohistochemistry; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar | 1999 |
Increased apoptosis susceptibility in mesangial cells from spontaneously hypertensive rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Cell Count; Cells, Cultured; Culture Media, Serum-Free; Enzyme Inhibitors; Glomerular Mesangium; Hypertension; In Situ Nick-End Labeling; Intracellular Fluid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Thapsigargin | 2000 |
Acetylcholine and bradykinin induce paradoxically amplified hypotensive response in hypertensive NO-deficient rats.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Bradykinin; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 1999 |
Decreased endothelium-dependent vascular relaxation during reduction of uterine perfusion pressure in pregnant rat.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; Methylene Blue; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Phenylephrine; Pregnancy; Pregnancy Complications, Cardiovascular; Rats; Rats, Sprague-Dawley; Uterus; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2000 |
Inhibition of nitric oxide synthesis potentiates hypertension during chronic glucose infusion in rats.
Topics: Animals; Blood Glucose; Blood Pressure; Endothelium, Vascular; Enzyme Inhibitors; Glomerular Filtration Rate; Glucose; Heart Rate; Hypertension; Infusions, Intravenous; Insulin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renin | 2000 |
Down-regulation of renal glutathione synthesis by systemic nitric oxide synthesis inhibition in spontaneously hypertensive rats.
Topics: Animals; Down-Regulation; Enzyme Inhibitors; Glutathione; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR | 2000 |
Chronic N(G)-nitro-L-arginine methyl ester-induced hypertension : novel molecular adaptation to systolic load in absence of hypertrophy.
Topics: Animals; Aortic Valve Stenosis; Blood Pressure; Calcium; Cardiomegaly; Cyclic GMP; Hypertension; Major Histocompatibility Complex; Male; Myocardial Contraction; Myocardium; NG-Nitroarginine Methyl Ester; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Systole; Transcription, Genetic | 2000 |
Nitric oxide and preglomerular vascular lesions in lyon spontaneously hypertensive rats.
Topics: Aging; Animals; Antihypertensive Agents; Azo Compounds; Coloring Agents; Drug Combinations; Enzyme Inhibitors; Hydralazine; Hypertension; Kidney Glomerulus; Naphthalenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Vascular Diseases | 2000 |
Effect of imidapril on myocardial remodeling in L-NAME-induced hypertensive rats is associated with gene expression of NOS and ACE mRNA.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Collagen; Disease Models, Animal; DNA Primers; Gene Expression; Heart Ventricles; Hypertension; Imidazoles; Imidazolidines; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Ventricular Remodeling | 2000 |
Changes of sodium and ATP affinities of the cardiac (Na,K)-ATPase during and after nitric oxide deficient hypertension.
Topics: Adenosine Triphosphate; Animals; Hypertension; Kinetics; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Reference Values; Sarcolemma; Sodium; Sodium-Potassium-Exchanging ATPase | 1999 |
Functional alterations of cardiac (Na,K)-ATPase in L-NAME induced hypertension.
Topics: Animals; Energy Metabolism; Enzyme Inhibitors; Heart; Hypertension; Kinetics; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred WKY; Sodium; Sodium-Potassium-Exchanging ATPase | 1999 |
Cardiac membrane proteins and phospholipids in L-NAME induced hypertension.
Topics: Animals; Enzyme Inhibitors; Hypertension; Male; Membrane Lipids; Membrane Proteins; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phospholipids; Rats; Rats, Inbred WKY; Reactive Oxygen Species | 1999 |
Effect of inhibition of nitric oxide synthase on blood pressure and renal sodium handling in renal denervated rats.
Topics: Animals; Blood Pressure; Denervation; Enzyme Inhibitors; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Sodium; Sympathetic Nervous System | 2000 |
Regression of chronic L -NAME-treatment-induced left ventricular hypertrophy: effect of captopril.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Body Weight; Captopril; Collagen; DNA; Heart Ventricles; Hypertension; Hypertrophy, Left Ventricular; Male; Muscle Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Rats; Rats, Wistar; Remission, Spontaneous; Renin-Angiotensin System; RNA; Ventricular Remodeling | 2000 |
Oxidative stress induced by tert-butyl hydroperoxide causes vasoconstriction in the aorta from hypertensive and aged rats: role of cyclooxygenase-2 isoform.
Topics: Aging; Animals; Aorta, Thoracic; Blotting, Western; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Indomethacin; Isoenzymes; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Oxidative Stress; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; tert-Butylhydroperoxide; Time Factors; Vasoconstriction | 2000 |
Selective cyclo-oxygenase-2 inhibition with celecoxib elevates blood pressure and promotes leukocyte adherence.
Topics: Animals; Aorta, Thoracic; Blood Pressure; Celecoxib; Cell Adhesion; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Endothelins; Hypertension; In Vitro Techniques; Isoenzymes; Leukocytes; Male; Muscle Contraction; NG-Nitroarginine Methyl Ester; Norepinephrine; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Rats; Rats, Wistar; Sulfonamides; Vasoconstrictor Agents | 2000 |
Cyclooxygenase inhibition reduces blood pressure elevation and vascular reactivity dysfunction caused by inhibition of nitric oxide synthase in rats.
Topics: Acetylcholine; Animals; Aorta, Thoracic; Blood Pressure; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Therapy, Combination; Enzyme Inhibitors; Heart Rate; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phenylephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2000 |
Salt-sensitive hypertension in endothelin-B receptor-deficient rats.
Topics: Animals; Animals, Genetically Modified; Blood Pressure; Coronary Vessels; Cyclooxygenase Inhibitors; Dopamine beta-Hydroxylase; Down-Regulation; Endothelin-1; Enzyme Inhibitors; Gene Deletion; Hypertension; Indomethacin; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Mutant Strains; Receptor, Endothelin B; Receptors, Endothelin; Renin-Angiotensin System; Sodium Chloride, Dietary | 2000 |
Mesenteric cyclooxygenase products after combined antihypertensive treatment in uninephrectomized SHRs.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Hypertension; Indoles; Indomethacin; Mesenteric Arteries; Myocardial Contraction; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Inbred SHR; Verapamil | 2000 |
Dysfunctional renal nitric oxide synthase as a determinant of salt-sensitive hypertension: mechanisms of renal artery endothelial dysfunction and role of endothelin for vascular hypertrophy and Glomerulosclerosis.
Topics: Acetylcholine; Animals; Endothelin Receptor Antagonists; Endothelin-1; Endothelium, Vascular; Enzyme Inhibitors; Glomerulosclerosis, Focal Segmental; Hypertension; Hypertrophy; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylpropionates; Pyrimidines; Rats; Rats, Inbred Dahl; Renal Artery; Sodium Chloride, Dietary; Vasodilator Agents | 2000 |
Induction of angiogenesis in NO-deficient rat heart.
Topics: Animals; Capillaries; Coronary Vessels; Endothelium, Vascular; Enzyme Inhibitors; Fibroblasts; Heart Ventricles; Hypertension; Male; Microscopy, Electron; Myocardium; Neovascularization, Pathologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2000 |
Histamine-induced relaxation in pulmonary artery of normotensive and hypertensive rats: relative contribution of prostanoids, nitric oxide and hyperpolarization.
Topics: Acetylcholine; Animals; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Histamine; Hypertension; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Potassium Channel Blockers; Potassium Channels; Prostaglandins; Pulmonary Artery; Rats; Rats, Wistar | 2000 |
Acute blood pressure effects of YC-1-induced activation of soluble guanylyl cyclase in normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Hypertension; Indazoles; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Aggregation Inhibitors; Rats; Rats, Inbred WKY | 2000 |
Short treatments of normotensive and hypertensive rats by angiotensin II and nitric oxide inhibitor induce an increase of noradrenaline sensitivity in isolated vena portae preparations.
Topics: Angiotensin II; Animals; Blood Pressure; Bradykinin; Drug Interactions; Ergotamine; Hypertension; In Vitro Techniques; Male; Minoxidil; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Portal Vein; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstriction | 2000 |
Protective effects of imidapril on He-Ne laser-induced thrombosis in cerebral blood vessels of stroke-prone spontaneously hypertensive rats.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Arterioles; Cerebral Arteries; Drug Evaluation, Preclinical; Female; Genetic Predisposition to Disease; Hemorheology; Hypertension; Imidazoles; Imidazolidines; Intracranial Thrombosis; Lasers; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred SHR | 2000 |
Effect of antihypertensive drugs on the myocardial microvessels in rats with nitric oxide blockade.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Coronary Circulation; Coronary Vessels; Disease Models, Animal; Enalapril; Enzyme Inhibitors; Heart; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Spironolactone; Verapamil | 2000 |
Role of bradykinins and nitric oxide in the AT2 receptor-mediated hypotension.
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Drug Administration Routes; Enzyme Inhibitors; Hot Temperature; Hypertension; Hypotension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Shock; Vasodilation | 2000 |
Polymorphonuclear leukocytes (PMNs) functions in SHR, L-NAME- and DOCA/salt-induced hypertensive rats.
Topics: Animals; Blood Cell Count; Blood Pressure; Cell Adhesion; Desoxycorticosterone; Hypertension; Male; Neutrophils; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Sodium Chloride; Superoxides | 2000 |
Constriction of resistance arteries determines l-NAME-induced hypertension in a conscious hamster model.
Topics: Animals; Arteries; Arterioles; Blood Flow Velocity; Consciousness; Cricetinae; Enzyme Inhibitors; Hypertension; Mesocricetus; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Skin; Vascular Resistance; Vasoconstrictor Agents | 2000 |
Cardiovascular effects of chronic nitric oxide synthase inhibition in genetically hypertensive rats.
Topics: Aging; Animals; Blood Pressure; Cardiomegaly; Dose-Response Relationship, Drug; Enzyme Inhibitors; Heart Rate; Hemodynamics; Hindlimb; Hypertension; Hypertrophy, Left Ventricular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Regional Blood Flow | 2000 |
Endothelin and blood pressure regulation in the female rat: studies in normal pregnancy and with nitric oxide synthase inhibition-induced hypertension.
Topics: Animals; Blood Pressure; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Female; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pregnancy; Pregnancy, Animal; Rats; Rats, Sprague-Dawley | 2000 |
Quantitative study of myocardial microcirculation in arterial hypertension due to progressive inhibition of NO synthesis.
Topics: Animals; Blood Pressure; Cardiomegaly; Coronary Vessels; Enzyme Inhibitors; Hypertension; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Rats; Rats, Wistar; Time Factors | 1999 |
Basilar artery remodelling in the genetically hypertensive rat: effects of nitric oxide synthase inhibition and treatment with valsartan and enalapril.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Basilar Artery; Blood Pressure; Brain; Enalapril; Enzyme Inhibitors; Hypertension; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Stroke; Tetrazoles; Valine; Valsartan; Ventricular Function, Left | 2000 |
Molecular plasticity of vascular wall during N(G)-nitro-L-arginine methyl ester-induced hypertension: modulation of proinflammatory signals.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta; Cell Adhesion; Cytokines; Enzyme Inhibitors; Gelatinases; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Hypertension; Male; Monocytes; NADPH Oxidases; NF-kappa B; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; RNA, Messenger; Superoxides; Tissue Inhibitor of Metalloproteinase-1 | 2000 |
Central infusion of L-arginine or superoxide dismutase does not alter arterial pressure in SHR.
Topics: Animals; Arginine; Blood Pressure; Cyclic N-Oxides; Enzyme Inhibitors; Free Radical Scavengers; Hypertension; Infusion Pumps; Injections, Intraventricular; Male; Medulla Oblongata; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitroso Compounds; Rats; Rats, Inbred SHR; Spin Labels; Superoxide Dismutase | 2000 |
Cardiovascular responses to glutamate and angiotensin II in ventrolateral medulla of hypertension induced by chronic inhibition of nitric oxide.
Topics: Angiotensin II; Animals; Blood Pressure; Cardiovascular System; Enzyme Inhibitors; Glutamic Acid; Heart Rate; Hypertension; Male; Medulla Oblongata; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Time Factors | 2000 |
Oestrogen attenuates the increases in blood pressure and platelet aggregation in ovariectomized and salt-loaded Dahl salt-sensitive rats.
Topics: Administration, Oral; Animals; Blood Pressure; Estradiol; Female; Hormone Replacement Therapy; Hypertension; NG-Nitroarginine Methyl Ester; Ovariectomy; Platelet Aggregation; Rats; Rats, Inbred Dahl; Sodium, Dietary | 2000 |
Angiotensin in the nucleus tractus solitarii contributes to neurogenic hypertension caused by chronic nitric oxide synthase inhibition.
Topics: Angiotensin Receptor Antagonists; Angiotensins; Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Brain Stem; Cerebral Ventricles; Enzyme Inhibitors; Gene Expression Regulation; Heart Rate; Hexamethonium; Hypertension; Imidazoles; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Peptidyl-Dipeptidase A; Pyridines; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; RNA, Messenger; Solitary Nucleus; Sympathetic Nervous System; Tetrazoles | 2000 |
Enhanced expression of Gi proteins in non-hypertrophic hearts from rats with hypertension-induced by L-NAME treatment.
Topics: Adenylyl Cyclases; Animals; Blotting, Northern; Blotting, Western; Cardiomegaly; Cholera Toxin; Densitometry; Enzyme Inhibitors; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Proto-Oncogene Proteins; Rats; Rats, Sprague-Dawley; RNA, Messenger; Stimulation, Chemical; Subcellular Fractions | 2000 |
Gene transfer of endothelial nitric oxide synthase but not Cu/Zn superoxide dismutase restores nitric oxide availability in the SHRSP.
Topics: Adenoviridae; Animals; Aorta; Biological Availability; Blotting, Western; Carotid Arteries; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Genetic Therapy; Genetic Vectors; Humans; Hypertension; Immunohistochemistry; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phenylephrine; Plasmids; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxide Dismutase; Transfection; Vasoconstrictor Agents | 2000 |
Nitric oxide improves membrane fluidity of erythrocytes in essential hypertension: An electron paramagnetic resonance investigation.
Topics: Arginine; Blood Pressure; Calcimycin; Cell Membrane; Cyclic GMP; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Hemorheology; Humans; Hypertension; Membrane Fluidity; Middle Aged; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Penicillamine; Spin Labels | 2000 |
Blood pressure and the susceptibility to renal damage after unilateral nephrectomy and L-NAME-induced hypertension in rats.
Topics: Albuminuria; Animals; Blood Pressure; Enzyme Inhibitors; Genetic Predisposition to Disease; Glomerular Filtration Rate; Glomerulosclerosis, Focal Segmental; Hypertension; In Vitro Techniques; Kidney; Nephrectomy; NG-Nitroarginine Methyl Ester; Postoperative Period; Rats; Rats, Inbred Strains; Regression Analysis; Systole | 2000 |
Enhanced NO inactivation and hypertension induced by a high-fat, refined-carbohydrate diet.
Topics: Animals; Arginine; Biomarkers; Blood Pressure; Body Weight; Dietary Carbohydrates; Dietary Fats; Enzyme Inhibitors; Female; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxidation-Reduction; Oxidative Stress; Rats; Rats, Inbred F344; Reactive Oxygen Species; Tyrosine | 2000 |
High-calcium diet enhances vasorelaxation in nitric oxide-deficient hypertension.
Topics: Adrenergic beta-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium, Dietary; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelium, Vascular; Heart; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Organ Size; Potassium Chloride; Rats; Rats, Wistar; Vasoconstriction; Vasodilation; Vasodilator Agents | 2000 |
Role of protein kinase C in electrical-stimulation-induced neuronal nitric oxide release in mesenteric arteries from hypertensive rats.
Topics: Animals; Carcinogens; Drug Synergism; Electric Stimulation; Enzyme Inhibitors; Hypertension; Male; Mesenteric Arteries; Muscle Contraction; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Protein Kinase C; Protein Synthesis Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2000 |
Nitric oxide may be required to prevent hypertension at the onset of diabetes.
Topics: Animals; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Enzyme Inhibitors; Glomerular Filtration Rate; Heart Rate; Hypertension; Infusions, Intravenous; Insulin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Sodium; Sodium, Dietary | 2000 |
Dexamethasone worsens nitric oxide inhibition-induced hypertension and renal dysfunction.
Topics: Animals; Blood Pressure; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glomerular Filtration Rate; Glucocorticoids; Hemodynamics; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Time Factors; Vasoconstriction | 2000 |
Deoxycorticosterone suppresses the effects of losartan in nitric oxide-deficient hypertensive rats.
Topics: Albuminuria; Animals; Blood Pressure; Blood Proteins; Creatinine; Desoxycorticosterone; Enzyme Inhibitors; Hypertension; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Renin; Sodium, Dietary | 2000 |
Renal cyclic 3',5'-guanosine monophosphate and sodium excretion in Dahl salt-resistant and Dahl salt-sensitive rats: comparison of the roles of bradykinin and nitric oxide.
Topics: Animals; Bradykinin; Cyclic GMP; Female; Hypertension; Kidney; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred Dahl; Sodium | 2000 |
Inhibition of nitric oxide synthesis increases erythrocyte membrane fluidity and unsaturated fatty acid content.
Topics: Animals; Blood Pressure; Delta-5 Fatty Acid Desaturase; Erythrocyte Membrane; Erythrocytes; Fatty Acid Desaturases; Fatty Acids, Unsaturated; Hypertension; Linoleoyl-CoA Desaturase; Membrane Fluidity; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Stearoyl-CoA Desaturase | 2000 |
Augmented expression of tissue endothelin-1 messenger RNA is a common feature in hypertensive rats.
Topics: Animals; Endothelin-1; Hypertension; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; RNA, Messenger | 2000 |
Red blood cell rheological alterations in hypertension induced by chronic inhibition of nitric oxide synthesis in rats.
Topics: Animals; Calcium; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocyte Aggregation; Erythrocyte Deformability; Hemorheology; Hypertension; Lipid Peroxidation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Thiobarbituric Acid Reactive Substances | 2000 |
Subpressor dose of L-NAME unmasks hypertensive effect of chronic hyperinsulinemia.
Topics: Animals; Blood Pressure; Chronic Disease; Dose-Response Relationship, Drug; Drug Implants; Enzyme Inhibitors; Hyperinsulinism; Hypertension; Insulin; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Vasodilation | 2000 |
Human coronary arteriolar dilation to adrenomedullin: role of nitric oxide and K(+) channels.
Topics: Adenine; Adrenomedullin; Aged; Arterioles; Calcitonin Gene-Related Peptide; Coronary Circulation; Coronary Disease; Coronary Vessels; Enzyme Inhibitors; Female; Heart Failure; Humans; Hypertension; In Vitro Techniques; Male; Microcirculation; Middle Aged; Miotics; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Peptide Fragments; Potassium Channels; Vasodilation; Vasodilator Agents | 2000 |
Tissue and blood levels of zinc, copper, and magnesium in nitric oxide synthase blockade-induced hypertension.
Topics: Animals; Copper; Enzyme Inhibitors; Hypertension; Magnesium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Zinc | 2000 |
New method for imaging innervation of the renal preglomerular vasculature. Alterations in hypertensive rats.
Topics: Adrenergic Fibers; Angiotensin II; Animals; Arteries; Disease Models, Animal; Hypertension; Immunohistochemistry; Kidney; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Synaptophysin | 2000 |
Cardiac sympathetic overactivity and decreased baroreflex sensitivity in L-NAME hypertensive rats.
Topics: Animals; Antihypertensive Agents; Atropine Derivatives; Baroreflex; Enzyme Inhibitors; Fourier Analysis; Heart; Heart Rate; Hypertension; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Acid; Parasympatholytics; Propranolol; Rats; Rats, Wistar; Sympathetic Nervous System; Tachycardia | 2001 |
Mechanisms of the increased pressor response to vasopressors in the mesenteric bed of nitric oxide-deficient hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Arteries; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesentery; Methoxamine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Potassium Chloride; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Vasoconstriction; Vasodilation; Verapamil | 2001 |
Influence of the chronic nitric oxide synthesis inhibition on cardiomyocytes number.
Topics: Animals; Antibodies, Monoclonal; Apoptosis; Cell Count; Enzyme Inhibitors; Female; Hypertension; In Situ Nick-End Labeling; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Tumor Suppressor Protein p53 | 2000 |
Nitric oxide does not participate in the metabolic effects of exogenous bradykinin in fructose-fed rats.
Topics: Animals; Blood Glucose; Blood Pressure; Bradykinin; Diet; Enzyme Inhibitors; Fructose; Hyperinsulinism; Hypertension; Hypertriglyceridemia; Infusions, Intravenous; Insulin; Lipids; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley | 2001 |
Relative deficiency of nitric oxide-dependent vasodilation in salt-hypertensive Dahl rats: the possible role of superoxide anions.
Topics: Animals; Captopril; Cyclic N-Oxides; Female; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred Dahl; Sodium Chloride; Spin Labels; Superoxides; Sympathetic Nervous System; Vasodilation | 2001 |
Role of the central nervous system in the development of hypertension produced by chronic nitric oxide blockade in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Central Nervous System; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hypertension; Losartan; Male; Microelectrodes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Renin-Angiotensin System | 2001 |
Effects of nitric oxide synthase inhibition on angiotensin receptors and metabolism in the pregnant hypertensive rat.
Topics: Analysis of Variance; Angiotensin II; Animals; Blood Pressure; Female; Hypertension; Metabolic Clearance Rate; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pregnancy; Pregnancy Complications, Cardiovascular; Proteinuria; Random Allocation; Rats; Rats, Inbred SHR; Receptors, Angiotensin | 2001 |
Angiotensin II increases neurogenic nitric oxide metabolism in mesenteric arteries from hypertensive rats.
Topics: Angiotensin II; Animals; Electric Stimulation; Hypertension; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Saralasin; Superoxide Dismutase; Superoxides | 2001 |
Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction.
Topics: Acetophenones; Aging; Animals; Aorta; Blood Pressure; Carotid Arteries; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; Immunohistochemistry; In Vitro Techniques; Luminescent Measurements; Membrane Transport Proteins; NADPH Dehydrogenase; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Onium Compounds; Phosphoproteins; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Superoxides | 2001 |
Effect of prolonged nitric oxide synthesis inhibition on plasma fibrinogen concentration in rats.
Topics: Animals; Antihypertensive Agents; Benzimidazoles; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Enzyme Inhibitors; Fibrinogen; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Tetrazoles | 2001 |
Interaction between nitric oxide and renal myogenic autoregulation in normotensive and hypertensive rats.
Topics: Animals; Enzyme Inhibitors; Hemodynamics; Homeostasis; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Inbred BN; Rats, Inbred SHR; Rats, Long-Evans; Rats, Sprague-Dawley; Renal Circulation | 2001 |
Evidence that Rho-kinase activity contributes to cerebral vascular tone in vivo and is enhanced during chronic hypertension: comparison with protein kinase C.
Topics: Amides; Animals; Basilar Artery; Blood Pressure; Cerebral Arteries; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; Male; NG-Nitroarginine Methyl Ester; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred WKY; Rats, Sprague-Dawley; rho-Associated Kinases; Species Specificity; Vasodilator Agents; Vasomotor System | 2001 |
Relevance of endothelium-derived hyperpolarizing factor in the effects of hypertension on rat coronary relaxations.
Topics: Acetylcholine; Animals; Biological Factors; Coronary Vessels; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Isoproterenol; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstriction; Vasodilation; Vasodilator Agents | 2001 |
Decreased influence of nitric oxide on deoxycorticosterone acetate (DOCA)-salt hypertension.
Topics: Acetylcholine; Animals; Arterioles; Desoxycorticosterone; Enzyme Inhibitors; Hypertension; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Sprague-Dawley; Reference Values; Sodium Chloride; Vasodilation; Vasodilator Agents | 2001 |
Comparison of arterial blood pressure in different strains of mice.
Topics: Animals; Animals, Outbred Strains; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Catheterization; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Rest | 2001 |
Long-term effect of bilateral ovariectomy on endothelial function in aortic rings of spontaneously hypertensive rats: role of nitric oxide.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Body Weight; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; Muscle Contraction; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Nitroprusside; Ovariectomy; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Superoxide Dismutase; Vasoconstriction | 2001 |
Altered mechanisms underlying hypoxic dilation of skeletal muscle resistance arteries of hypertensive versus normotensive Dahl rats.
Topics: Animals; Arachidonic Acid; Arteries; Cytochrome P-450 Enzyme System; Fatty Acids, Unsaturated; Hydroxyeicosatetraenoic Acids; Hypertension; Hypoxia; In Vitro Techniques; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred Dahl; Vascular Resistance; Vasodilation | 2001 |
Mycophenolate mofetil prevents salt-sensitive hypertension resulting from nitric oxide synthesis inhibition.
Topics: Animals; Blood Pressure; Body Weight; Glomerulosclerosis, Focal Segmental; Hypertension; Immunosuppressive Agents; Kidney; Lymphocytes; Macrophages; Male; Mycophenolic Acid; Nephritis, Interstitial; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2001 |
The role of haem oxygenase in renal vascular reactivity in normotensive and hypertensive rats.
Topics: Animals; Blood Pressure; Carbon Monoxide; Heme Oxygenase (Decyclizing); Hemin; Hypertension; In Vitro Techniques; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Perfusion; Phenylephrine; Protoporphyrins; Rats; Rats, Inbred SHR; Rats, Wistar; Renal Circulation | 2001 |
Inhibition of nitric oxide synthesis accentuates blood pressure elevation in hyperinsulinemic rats.
Topics: Animals; Blood Pressure; Drug Synergism; Enzyme Inhibitors; Hyperinsulinism; Hypertension; Insulin; Insulin Resistance; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Artery | 2001 |
Dietary soy exerts an antihypertensive effect in spontaneously hypertensive female rats.
Topics: Animals; Blood Pressure; Caseins; Chlorisondamine; Diet; Enzyme Inhibitors; Female; Ganglionic Blockers; Genistein; Glycine max; Heart Rate; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovariectomy; Physical Stimulation; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 2001 |
Effect of methyldopa on renal function in rats with L-NAME-induced hypertension in pregnancy.
Topics: Animals; Arginine; Diltiazem; Drinking; Eating; Female; Hypertension; Kidney; Methyldopa; NG-Nitroarginine Methyl Ester; Nitrates; Pregnancy; Pregnancy Complications; Rats; Rats, Wistar | 2001 |
Electron paramagnetic resonance investigation on modulatory effect of 17beta-estradiol on membrane fluidity of erythrocytes in postmenopausal women.
Topics: Aged; Arginine; Cyclic GMP; Electron Spin Resonance Spectroscopy; Erythrocytes; Estradiol; Female; Humans; Hypertension; In Vitro Techniques; Membrane Fluidity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Penicillamine; Postmenopause; S-Nitroso-N-Acetylpenicillamine | 2001 |
Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats.
Topics: Anesthesia; Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta; Aspirin; Blood Pressure; Consciousness; Dose-Response Relationship, Drug; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Nitroprusside; Phenylephrine; Rats; Rats, Wistar; Renin; Thromboxanes; Vasodilation | 2001 |
Plasminogen activator inhibitor-1 deficiency prevents hypertension and vascular fibrosis in response to long-term nitric oxide synthase inhibition.
Topics: Animals; Blood Pressure; Body Weight; Collagen; Coronary Vessels; Enzyme Inhibitors; Fibrosis; Hemodynamics; Hypertension; Hypertrophy, Left Ventricular; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Plasminogen Activator Inhibitor 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time | 2001 |
Role of nitric oxide in regional blood flow in angiotensin II-induced hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blood Circulation; Enzyme Inhibitors; Hemodynamics; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitro Compounds; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 2001 |
Vasorelaxant effects of the chronic treatment with melatonin on mesenteric artery and aorta of spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Calcimycin; Enzyme Inhibitors; Hypertension; Ionophores; Male; Melatonin; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Time Factors; Vasodilation; Vasodilator Agents; Vasomotor System | 2001 |
Efficiency of NO donors in substituting impaired endogenous NO production: a functional and morphological study.
Topics: Acetylcholine; Animals; Blood Pressure; Bradykinin; Enzyme Activation; Enzyme Inhibitors; Hypertension; Isosorbide Dinitrate; Male; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Rats; Rats, Wistar; Vasodilator Agents | 2001 |
Increased expression and activity of RhoA are associated with increased DNA synthesis and reduced p27(Kip1) expression in the vasculature of hypertensive rats.
Topics: Androstadienes; Animals; Aorta; Arteries; Blood Vessels; Blotting, Western; Cell Cycle Proteins; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclin-Dependent Kinase Inhibitor p27; Cyclins; DNA; Hypertension; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Phosphatidylinositol 3-Kinases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; rhoA GTP-Binding Protein; Species Specificity; Tail; Thrombin; Tumor Suppressor Proteins; Wortmannin | 2001 |
Effects of nitric oxide synthase inhibition and low-salt diet on blood pressure and mesenteric resistance artery remodelling in genetically hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Heart Ventricles; Hypertension; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Sodium Chloride, Dietary; Systole; Tetrazoles; Valine; Valsartan; Vascular Resistance | 2001 |
Chronic inhibition of NO synthesis per se promotes structural intimal remodeling of the rat aorta.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Captopril; Drug Synergism; Enzyme Inhibitors; Hypertension; Male; Microscopy, Electron; Microscopy, Electron, Scanning; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Time Factors; Tunica Intima | 2001 |
Cardiovascular neural reflexes in L-NAME-induced hypertension in mice.
Topics: Animals; Baroreflex; Blood Pressure; Cardiovascular System; Chemoreceptor Cells; Enzyme Inhibitors; Heart Rate; Hypertension; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenylephrine; Vasoconstrictor Agents | 2001 |
Hypertension and impairment of endothelium-dependent relaxation of arteries from spontaneously hypertensive and L-NAME-treated Wistar rats.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Body Weight; Carotid Arteries; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; Iliac Artery; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilator Agents | 2001 |
Influence of irbesartan and enalapril on changes of renal function associated with the established phase of l-NAME hypertension.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Blood Vessels; Cardiovascular System; Drug Combinations; Enalapril; Enzyme Inhibitors; Hemodynamics; Hypertension; Irbesartan; Kidney; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Renal Circulation; Tail; Tetrazoles | 2001 |
Blood pressure variability is increased in genetic hypertension and L-NAME -induced hypertension.
Topics: Animals; Blood Pressure; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Random Allocation; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley | 2001 |
Nitric oxide synthase blockade and body fluid volumes.
Topics: Animals; Body Fluids; Enzyme Inhibitors; Extracellular Space; Hypertension; Kidney; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Plasma Volume; Rats; Rats, Wistar | 2002 |
Apoptosis and glomerular injury after prolonged nitric oxide synthase inhibition in spontaneously hypertensive rats.
Topics: Angiotensin II; Animals; Apoptosis; Hypertension; Immunohistochemistry; Kidney; Kidney Glomerulus; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Rats; Rats, Inbred SHR; Regional Blood Flow | 2001 |
Attenuation of hypertension, cardiomyocyte hypertrophy, and myocardial fibrosis by beta-adrenoceptor blockers in rats under long-term blockade of nitric oxide synthesis.
Topics: Adrenergic beta-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Atenolol; Blood Pressure; Body Weight; Enzyme Inhibitors; Fibrosis; Heart; Hypertension; Hypertrophy, Left Ventricular; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organ Size; Propranolol; Rats; Rats, Wistar; Time Factors | 2002 |
Reduced endothelial NO-cGMP vascular relaxation pathway during TNF-alpha-induced hypertension in pregnant rats.
Topics: Acetylcholine; Animals; Antineoplastic Agents; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Female; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Oxadiazoles; Phenylephrine; Pregnancy; Pregnancy Complications, Cardiovascular; Quinoxalines; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2002 |
Abrogated leptin-induced cardiac contractile response in ventricular myocytes under spontaneous hypertension: role of Jak/STAT pathway.
Topics: Animals; Blood Pressure; Calcium; Carrier Proteins; Cell Size; DNA-Binding Proteins; Enzyme Inhibitors; Heart Ventricles; Hypertension; Imidazoles; Janus Kinase 2; Leptin; Mitogen-Activated Protein Kinase Kinases; Myocardial Contraction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Cell Surface; Receptors, Leptin; Signal Transduction; STAT3 Transcription Factor; Trans-Activators; Tyrphostins; Ventricular Dysfunction, Left | 2002 |
Salt-sensitive hypertension resulting from nitric oxide synthase inhibition is associated with loss of regulation of angiotensin II in the rat.
Topics: Aldosterone; Angiotensin I; Angiotensin II; Angiotensinogen; Animals; Blood Pressure; Enzyme Inhibitors; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptidyl-Dipeptidase A; Rats; Rats, Inbred WKY; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary | 2002 |
Effects of angiotensin blockade in the rostral ventrolateral medulla on maintenance of hypertension induced by chronic L-NAME treatment.
Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Enzyme Inhibitors; Glycine; Hypertension; Injections, Intraventricular; Losartan; Male; Medulla Oblongata; Microinjections; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Receptors, Angiotensin | 2002 |
Augmented adrenergic vasoconstriction in hypertensive diabetic obese Zucker rats.
Topics: Angiotensin II; Animals; Arteries; Arterioles; Blood Pressure; Diabetes Mellitus; Endothelins; Heart Rate; Hypertension; Male; Microcirculation; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Obesity; Phentolamine; Propranolol; Rats; Rats, Zucker; Thinness; Vasoconstriction | 2002 |
Wine polyphenols improve cardiovascular remodeling and vascular function in NO-deficient hypertension.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Body Weight; Cardiovascular Physiological Phenomena; Enzyme Inhibitors; Flavonoids; Hypertension; In Vitro Techniques; Leucine; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Norepinephrine; Organ Size; Phenols; Polymers; Polyphenols; Rats; Rats, Wistar; Wine | 2002 |
Nitric oxide reduces blood pressure in the nucleus tractus solitarius: a real time electrochemical study.
Topics: Animals; Arginine; Biosensing Techniques; Blood Pressure; Bradycardia; Cats; Computer Systems; Electrochemistry; Enzyme Inhibitors; Extracellular Space; Female; Guanosine Monophosphate; Guanylate Cyclase; Hemoglobins; Hypertension; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pressoreceptors; Quinoxalines; Reflex; Sensitivity and Specificity; Solitary Nucleus; Tachycardia; Vagotomy | 2002 |
Hypertension-related intermyocyte junction remodelling is associated with a higher incidence of low-K(+)-induced lethal arrhythmias in isolated rat heart.
Topics: Animals; Enzyme Inhibitors; Hypertension; Hypokalemia; In Vitro Techniques; Incidence; Intercellular Junctions; Male; Microscopy, Electron; Muscle Fibers, Skeletal; Myocardium; NG-Nitroarginine Methyl Ester; Potassium; Rats; Rats, Wistar; Ventricular Fibrillation | 2002 |
Effect of nitric oxide synthase inhibitor N(omega) nitro-L-arginine methyl ester on relaxant responses to calcium channel antagonists in isolated aortic rings from Dahl normotensive and hypertensive rats.
Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Diltiazem; Enzyme Inhibitors; Female; Hypertension; Imidazoles; In Vitro Techniques; Mibefradil; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide Synthase; Potassium Chloride; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Vasoconstrictor Agents; Vasodilation | 2002 |
Alterations of the nitric oxide pathway in cerebral arteries from spontaneously hypertensive rats.
Topics: Animals; Arginine; Blotting, Western; Chromatography, Thin Layer; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Lipopolysaccharides; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Up-Regulation; Vasoconstriction | 2002 |
Endothelial dysfunction in cold-induced hypertensive rats.
Topics: Acetylcholine; Animals; Aorta; Blood Pressure; Cold Temperature; Endothelium, Vascular; Enzyme Inhibitors; Heart Rate; Hypertension; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Vasodilator Agents | 2002 |
Salt-sensitive hypertension in conscious rats induced by chronic nitric oxide blockade.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Kidney Cortex; Kidney Medulla; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Reference Values; Renal Circulation; Sodium; Sodium Chloride | 2002 |
Altered balance of main vasopressor and vasodepressor systems in rats with genetic hypertension and hypertriglyceridaemia.
Topics: Analysis of Variance; Animals; Cyclic N-Oxides; Enzyme Inhibitors; Female; Hypertension; Hypertriglyceridemia; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentolinium Tartrate; Rats; Rats, Inbred Lew; Rats, Wistar; Renin-Angiotensin System; Sex Factors; Spin Labels; Superoxides; Sympathetic Nervous System | 2002 |
The pressor effect of NO synthase inhibition correlates to pre-existing systolic BP in the rat.
Topics: Albumins; Animals; Arginine; Blood Pressure; Blood Vessels; Denervation; Endothelium, Vascular; Enzyme Inhibitors; Homeostasis; Hypertension; Hypovolemia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phenylephrine; Rats; Rats, Sprague-Dawley; Stress, Mechanical; Systole; Vasoconstrictor Agents; Vasodilation | 2002 |
[Renal effects of the chronic inhibition of nitric oxide synthesis in cirrhotic rats with ascites].
Topics: Animals; Ascites; Blood Pressure; Carbon Tetrachloride; Diuresis; Glomerular Filtration Rate; Guanidines; Hypertension; Kidney; Liver Cirrhosis, Experimental; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Rats; Rats, Sprague-Dawley; Renal Circulation | 2001 |
Red blood cell rheological properties in various rat hypertension models.
Topics: Animals; Aorta, Abdominal; Blood Pressure; Desoxycorticosterone; Disease Models, Animal; Hemorheology; Hypertension; Hypertension, Renal; Hypertension, Renovascular; Male; NG-Nitroarginine Methyl Ester; Platelet Aggregation; Rats | 2002 |
The impact of insulin-like growth factor-1 on the pattern of cardiac elongation factor-2 variants in a model of overload.
Topics: Animals; Apoptosis; Body Weight; Cardiomegaly; Disease Models, Animal; DNA Fragmentation; Enzyme Inhibitors; Genetic Variation; Heart; Hemodynamics; Hypertension; Insulin-Like Growth Factor I; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Elongation Factor 2; Rats; Rats, Wistar | 2002 |
Exercise conditioning attenuates the hypertensive effects of nitric oxide synthase inhibitor in rat.
Topics: Animals; Blood Pressure; Catalase; Enzyme Inhibitors; Glutathione; Glutathione Reductase; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Physical Conditioning, Animal; Rats; Rats, Inbred F344; Superoxide Dismutase | 2002 |
Neuronal NO mediates cerebral vasodilator responses to K+ in hypertensive rats.
Topics: Animals; Barium; Basilar Artery; Cerebral Arteries; Chronic Disease; Enzyme Inhibitors; Hypertension; Imidazoles; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Potassium; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sodium-Potassium-Exchanging ATPase; Vasodilation | 2002 |
Nitric oxide in mesenteric vascular reactivity: a comparison between rats with normotension and hypertension.
Topics: Acetylcholine; Animals; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Phenylephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity; Splanchnic Circulation; Vasoconstrictor Agents; Vasodilator Agents | 2002 |
Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo.
Topics: Acetylcholine; Amides; Animals; Antihypertensive Agents; Basilar Artery; Calcium Channel Blockers; Calcium Channels; Chronic Disease; Enzyme Inhibitors; Hypertension; Intracellular Signaling Peptides and Proteins; NG-Nitroarginine Methyl Ester; Nicardipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; rho-Associated Kinases; Serotonin; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2002 |
The altered balance between sympathetic nervous system and nitric oxide in salt hypertensive Dahl rats: ontogenetic and F2 hybrid studies.
Topics: Aging; Animals; Blood Pressure; Cyclic N-Oxides; Enzyme Inhibitors; Free Radical Scavengers; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentolinium Tartrate; Rats; Rats, Inbred Dahl; Sodium Chloride; Spin Labels; Superoxides; Sympathetic Nervous System; Vasoconstriction; Vasodilation | 2002 |
Increased basal nitric oxide release despite enhanced free radical production in hypertension.
Topics: Acetylcholine; Animals; Antioxidants; Aorta; Ascorbic Acid; Enzyme Inhibitors; Fluorescein; Hypertension; In Vitro Techniques; Indicators and Reagents; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species | 2002 |
Potential roles of plasminogen activator system in coronary vascular remodeling induced by long-term nitric oxide synthase inhibition.
Topics: Animals; Body Weight; Coronary Disease; Coronary Vessels; Enzyme Inhibitors; Fibrosis; Hemodynamics; Hypertension; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Plasminogen Activators; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta | 2002 |
Effect of exercise on blood pressure in rats with chronic NOS inhibition.
Topics: Adaptation, Physiological; Animals; Aorta; Blood Pressure; Body Weight; Chronic Disease; Heart; Heart Rate; Hypertension; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Physical Conditioning, Animal; Rats; Rats, Wistar | 2002 |
Intrarenal detection of nitric oxide using electron spin resonance spectroscopy in hypertensive lipopolysaccharide-treated rats.
Topics: Animals; Electron Spin Resonance Spectroscopy; Hypertension; Kidney; Lipopolysaccharides; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Sepsis | 2002 |
Effects of losartan on the blood-brain barrier permeability in long-term nitric oxide blockade-induced hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Blood-Brain Barrier; Coloring Agents; Enzyme Inhibitors; Evans Blue; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2002 |
Alpha-lactorphin and beta-lactorphin improve arterial function in spontaneously hypertensive rats.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitroprusside; Oligopeptides; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation; Vasodilator Agents | 2002 |
L-arginine dilates rat pial arterioles by nitric oxide-dependent mechanisms and increases blood flow during focal cerebral ischaemia.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Arterioles; Brain Ischemia; Cerebrovascular Circulation; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pia Mater; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Stereoisomerism; Vasodilation | 1992 |
Impaired response to acetylcholine despite intact endothelium-derived relaxing factor/nitric oxide in isolated microperfused afferent arterioles of the spontaneously hypertensive rat.
Topics: Acetylcholine; Animals; Arginine; Arterioles; Hypertension; Kidney Glomerulus; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasodilation | 1992 |
Sustained hypertension in the rat induced by chronic blockade of nitric oxide production.
Topics: Animals; Arginine; Blood Pressure; Body Weight; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renin; Sodium; Time Factors | 1992 |
Deficient production of nitric oxide induces volume-dependent hypertension.
Topics: Animals; Arginine; Endothelium, Vascular; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Renal Circulation | 1992 |
Influence of endothelium in the in vitro vasorelaxant effect of magnesium on aortic basal tension in DOCA-salt hypertensive rat.
Topics: Animals; Aorta, Thoracic; Arginine; Desoxycorticosterone; Endothelium, Vascular; Hypertension; In Vitro Techniques; Indomethacin; Magnesium; Male; Muscle Contraction; NG-Nitroarginine Methyl Ester; Norepinephrine; Rats; Rats, Sprague-Dawley; Vasodilation | 1992 |
Effects of endothelin upon blood pressure in normotensive rabbits and in perinephritis hypertension.
Topics: Animals; Arginine; Blood Pressure; Calcium; Calcium Channel Blockers; Endothelins; Hypertension; Indomethacin; Male; NG-Nitroarginine Methyl Ester; Nifedipine; Nitric Oxide; Perinephritis; Prostaglandins; Rabbits; Time Factors | 1992 |
Nitric oxide synthase inhibitors cause sustained, but reversible, hypertension and hindquarters vasoconstriction in Brattleboro rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Hemodynamics; Hindlimb; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Rats; Rats, Brattleboro; Vasoconstrictor Agents | 1992 |
Determinants of aortic cyclic guanosine monophosphate in hypertension induced by chronic inhibition of nitric oxide synthase.
Topics: Amino Acid Oxidoreductases; Animals; Aorta; Arginine; Atrial Natriuretic Factor; Blood Pressure; Body Weight; Cyclic GMP; Hypertension; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroprusside; Organ Size; Rats; Rats, Inbred Strains | 1992 |
Effect of N(G)-nitro-L-arginine methyl ester on the hypotensive and hypertensive responses to 5-hydroxytryptamine in pithed rats.
Topics: Animals; Appetite Depressants; Arginine; Blood Pressure; Drug Interactions; Endothelium, Vascular; Heart Rate; Hypertension; Hypotension; Ketanserin; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists | 1992 |
Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.
Topics: Animals; Antihypertensive Agents; Arginine; Biphenyl Compounds; Blood Pressure; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred Strains; Renal Circulation; Tail; Tetrazoles; Time Factors | 1992 |
Influence of N omega-nitro-L-arginine methyl on pressor responses elicited by sympathetic nerve stimulation in pithed normotensive and hypertensive rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Blood Pressure; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Sympathetic Nervous System | 1991 |
In vivo involvement of endothelium-derived nitric oxide in spontaneously hypertensive rats: effects of NG-nitro-L-arginine methyl ester.
Topics: Acetylcholine; Animals; Arginine; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Hypertension; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY | 1991 |