ng-nitroarginine methyl ester has been researched along with Ache in 112 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 32 (28.57) | 18.2507 |
2000's | 55 (49.11) | 29.6817 |
2010's | 16 (14.29) | 24.3611 |
2020's | 9 (8.04) | 2.80 |
Authors | Studies |
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Abbaszadeh, F; Fakhri, S; Farzaei, MH; Mohammadi, S; Mohammadi-Farani, A | 1 |
Hashemi, M; Karami, M; Zarrindast, M | 1 |
Flores-Murrieta, FJ; Gonzalez-Cortazar, M; Herrera-Ruiz, ML; Juárez-Aragón, MC; Molina-Cabrera, J; Montiel-Ruiz, RM; Vargas-Ruiz, R; Zamilpa, A | 1 |
Chen, YW; Chou, AK | 1 |
Arslan, G; Demirkazik, A; Ozdemir, E; Pelit, A; Taskiran, AS | 1 |
Capim, SL; Côrtes, WDS; Gonçalves, GM; Laureano-Melo, R; Marinho, BG; Oliveira, PA; Vasconcellos, MLAA | 1 |
Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R | 1 |
Ahmadi-Zeidabadi, M; Jeddi, S; Kohlmeier, KA; Mohammadi, F; Shabani, M | 1 |
Abbaszadeh, F; Ahmadpour, Y; Fakhri, S; Ghanbarveisi, F; Gravandi, MM; Iranpanah, A; Kooshki, L; Moradi, SZ; Rezaei, H | 1 |
Bandeira, PN; Campos, AR; da Silva, AW; de Menezes, JESA; Dos Reis Lima, J; Dos Santos, HS; Evaristo, FFV; Ferreira, MKA; Holanda, CLA; Magalhães, FEA; Silva, FCO; Teixeira, EH | 1 |
Fouladzadeh, A; Ghafghazi, S; Moghimi, M; Nemati, Y; Parvardeh, S; Safaripour, S | 1 |
Milovanović, A; Prostran, M; Srebro, DP; Vučetić, Č; Vučković, S; Vujović, KS | 1 |
Antunes, E; Camargo, EA; Costa, SK; Cotrim, C; Landucci, EC; Muscara, MN; Santana, DG; Silva, CI; Teixeira, SA; Toyama, MH | 1 |
Bhattacharya, SK; Gupta, LK; Gupta, R | 1 |
Prostran, MS; Savic Vujovic, KR; Srebro, DP; Vucković, SM | 1 |
Fernandes, PD; Giorno, TBS; Pinto, ADC; Silva, BVD | 1 |
Ji, YH; Jiang, F; Liu, T; Pang, XY | 1 |
Chung, E; Ohgami, Y; Quock, RM; Shirachi, DY; Zelinski, LM | 2 |
Baek, WY; Han, CG; Hong, JG; Jeon, Y; Kim, SO; Kwak, KH; Lee, SH; Lim, DG; Park, SS | 1 |
Amaral, JF; Araújo, FL; Barbosa-Filho, JM; de Sousa, FC; Gutierrez, SJ; Leite, CP; Melo, CT; Moura, BA; Rocha, NF; Vasconcelos, SM; Viana, GS | 1 |
Hashemi, M; Karami, M; Sahebgharani, M; Zarrindast, MR | 1 |
Andrade, EL; Calixto, JB; Dutra, RC; Nguelefack, TB; Paszcuk, AF; Tapondjou, LA | 1 |
Ji, G; Li, Z; Neugebauer, V | 1 |
Beitz, AJ; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY | 1 |
Baydemir, C; Dogan, AE; Erol, K; Kilic, FS | 1 |
Chu, SC; Hu, YY; Li, HN; Li, QJ; Li, WB | 1 |
Ambrosio, SR; Arakawa, NS; Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Mizokami, SS; Verri, WA; Zarpelon, AC | 1 |
Cheng, JT; Chuang, YC; Lin, CR; Wang, CJ; Yang, LC | 1 |
Jain, NK; Kulkarni, SK; Patil, CS; Singh, A | 3 |
Bocheva, A; Lazarova, M | 1 |
Johns, RA; Li, D; Liaw, WJ; Mao, P; Raja, SN; Tao, F; Tao, YX; Zhao, C | 1 |
Yang, B; Zeng, YM; Zhang, LC | 1 |
Ando, R; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Watanabe, C | 1 |
Déciga-Campos, M; López-Muñoz, FJ | 1 |
Llorente, J; Pineda, J; Ruiz-Durantez, E; Ugedo, L; Ulibarri, I | 1 |
Jain, NK; Kulkarni, SK; Patil, CS; Singh, VP | 1 |
Del Bel, EA; Echeverry, MB; Guimarães, FS | 1 |
Lee, CH; Lui, PW | 1 |
Déciga-Campos, M; Díaz-Reval, MI; González-Trujano, ME; López-Muñoz, FJ; Ventura-Martínez, R | 1 |
Castañeda-Hernández, G; Granados-Soto, V; Lozano-Cuenca, J | 1 |
Al-Shabanah, OA; El-Hadiyah, TM; Khattab, MM; Raza, M | 1 |
Dehpour, AR; Javanmardi, K; Keshavarz, M; Minaii, B; Parviz, M; Sadr, SS | 1 |
Aronov, S; Ben-Abraham, R; Givati-Divshi, D; Katz, Y | 2 |
Kamei, J; Saitoh, A; Tamura, N | 1 |
Granados-Soto, V; Torres-López, JE | 1 |
Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M | 1 |
Araiza-Saldaña, CI; Bermúdez-Ocaña, DY; Granados-Soto, V; Pérez-Severiano, F; Reyes-García, G | 1 |
Chacur, M; Green, P; Maier, SF; Martin, D; Milligan, E; Poole, S; Schoeniger, D; Watkins, LR; Zapata, V | 1 |
Lymans'kyĭ, IuP; Sushko, BS | 1 |
Aypar, U; Dal, D; Iskit, AB; Salman, AE; Salman, MA | 1 |
Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T | 1 |
Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D | 1 |
Chambers, JP; Johnson, CB; Lizarraga, I | 1 |
Abdel-Hady, RH; Abdel-Rahman, S; Abdel-Zaher, AO; Aly, SA; Hamdy, MM | 1 |
Kulkarni, SK; Padi, SV; Patil, CS; Singh, VP | 1 |
Abdullah, FC; Balakhrisnan, G; Jais, AM; Jayaraman, KV; Somchit, MN; Sulaiman, MR; Zakaria, ZA | 1 |
Campos, AR; David, JM; David, JP; Lima-Júnior, RC; Maia, JL; Melo, CM; Rao, VS; Santos, FA | 1 |
Chena, LX; Duan, X; Gao, YF; Qia, YM; Wangb, R; Yang, DJ | 1 |
Bagetta, G; Komatsu, T; Sakurada, C; Sakurada, S; Sakurada, T; Sanai, K; Sasaki, M; Tsuzuki, M | 1 |
Erdos, B; Komjáti, K; Lacza, Z; Mersich, T; Sándor, P; Szelke, E | 1 |
Cavalcante, IF; Ribeiro, RA; Rolim, DE; Souza, MH; Vale, ML | 1 |
Abacioglu, N; Altug, S; Tunctan, B; Uludag, O; Zengil, H | 1 |
Cheng, J; Han, JS; Kream, RM; Stefano, GB; Zhang, C | 1 |
Azevedo, AO; Braga, FC; Campos, JJ; Duarte, ID; Galdino, GS; Perez, AC | 1 |
Cuzzocrea, S; Esposito, E; Fabrizi, F; Masini, E; Matuschak, GM; Mollace, V; Muscoli, C; Ndengele, MM; Porreca, F; Salvemini, D | 1 |
Jesse, CR; Nogueira, CW; Savegnago, L | 1 |
Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ | 1 |
Kawabata, A; Manabe, S; Manabe, Y; Takagi, H | 1 |
Coderre, TJ; Yashpal, K | 1 |
Hayaishi, O; Hyodo, M; Ito, S; Minami, T; Nishihara, I; Sakamoto, K | 1 |
Babbedge, RC; Gaffen, ZA; Hart, SL; Moore, PK; Wallace, P | 1 |
Feria, M; Niedbala, B; Sánchez, A | 1 |
Asano, H; Mizuguchi, T; Shimoyama, N; Yamamoto, T | 1 |
Malmberg, AB; Yaksh, TL | 1 |
Besse, D; Dubner, R; Ren, K; Ruda, MA; Thomas, DA | 1 |
Hayaishi, O; Ito, S; Minami, T; Mori, H; Okuda-Ashitaka, E; Onaka, M | 1 |
Dawson, TM; Hanley, DF; Lam, HH; Raja, S; Saito, S; Trapp, BD; Yamaguchi, H | 1 |
Naito, H; Yamaguchi, H | 1 |
Hao, JX; Xu, XJ | 1 |
Hara, N; Imanishi, T; Ito, S; Minami, T; Mori, H; Okuda-Ashitaka, E; Onaka, M; Sakai, M; Shingu, K; Sugimoto, T | 1 |
Ding, Z; Holthusen, H | 1 |
Labuz, D; Machelska, H; Przewłocka, B; Przewłocki, R | 1 |
Hämäläinen, MM; Lovick, TA | 1 |
Inoue, T; Mashimo, T; Shibata, M; Shibuta, S; Yoshiya, I | 1 |
Abacioğlu, N; Görgün, CZ; Güney, HZ; Hodoğlugil, U; Tunçtan, B; Uludağ, O; Zengil, H | 1 |
Gordh, T | 1 |
Lewin, MR; Walters, ET | 1 |
Archer, DP; Roth, SH | 1 |
Capone, F; Machelska, H; Pavone, F; Przewłocka, B | 1 |
Beirith, A; Bonetti, VR; Calixto, JB; Creczynski-Pasa, TB; Franco, CV; Konzen, M; Paula, MS; Seifriz, I | 1 |
Goto, K; Ishige, A; Kamei, J; Komatsu, Y; Suzuki, Y | 1 |
Jain, NK; Kulkarni, SK | 1 |
Belt, ML; Doyle, JM; Mathur, SP; Seaman, RL | 1 |
Aguirre-Bañuelos, P; Granados-Soto, V | 1 |
Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD | 1 |
Abacioğlu, N; Cakici, I; Demir, S; Kanzik, I; Tunçtan, B | 1 |
Francés, B; Latapie, JP; Zajac, JM | 1 |
Hismiogullari, ES; Morris, R; Nazli, M; Thippeswamy, T | 1 |
Kisara, K; Nakayama, M; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Yonezawa, A | 1 |
Abdoli, N; Abdollahi, M; Nikfar, S | 1 |
Granados-Soto, V; Lázaro-Ibáñez, GG; Torres-López, JE | 1 |
da Rocha, FA; da S Rocha, JC; de A Ribeiro, R; de Q Cunha, F; Jancar, S; Peixoto, ME | 1 |
Chapman, V; Dickenson, A; Haley, J; Schachter, M | 1 |
Pieper, GM; Tseng, LF; Xu, JY | 1 |
Babbedge, RC; Gaffen, Z; Hart, SL; Moore, PK; Morgan, CV; Wallace, P | 1 |
Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS | 1 |
Babbedge, RC; Hart, SL; Moore, PK; Oluyomi, AO; Wallace, P | 1 |
Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D | 1 |
1 review(s) available for ng-nitroarginine methyl ester and Ache
Article | Year |
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Electrophysiological approaches to the study of bradykinin and nitric oxide in inflammatory pain.
Topics: Animals; Arginine; Bradykinin; Formaldehyde; Inflammation; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Pain; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Spinal Cord | 1992 |
111 other study(ies) available for ng-nitroarginine methyl ester and Ache
Article | Year |
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Astaxanthin engages the l-arginine/NO/cGMP/KATP channel signaling pathway toward antinociceptive effects.
Topics: Analgesics; Animals; Arginine; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Glyburide; KATP Channels; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Signal Transduction; Sildenafil Citrate; Xanthophylls | 2021 |
The regulatory role of nitric oxide in morphine-induced analgesia in the descending path of pain from the dorsal hippocampus to the dorsolateral periaqueductal gray.
Topics: Analgesia; Animals; Hippocampus; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Periaqueductal Gray; Rats; Rats, Wistar | 2022 |
Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception.
Topics: Adenosine Triphosphate; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Bicuculline; Edema; Glyburide; Hexanes; Mice; Naloxone; NG-Nitroarginine Methyl Ester; Pain; Plant Extracts; Plant Leaves; Rhus | 2023 |
N(Omega)-nitro-l-arginine methyl ester potentiates lidocaine analgesic and anaesthetic effect in rats.
Topics: Analgesics; Anesthetics; Animals; Lidocaine; NG-Nitroarginine Methyl Ester; Pain; Rats; Rats, Sprague-Dawley | 2023 |
The effects of extremely low-frequency pulsed electromagnetic fields on analgesia in the nitric oxide pathway.
Topics: Analgesia; Animals; Arginine; Electromagnetic Fields; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Management; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Temperature | 2019 |
Pharmacological evaluation underlying the antinociceptive activity of two new hybrids NSAIDs tetrahydropyran derivatives.
Topics: Adenosine Triphosphate; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Formaldehyde; Glyburide; Humans; Male; Mice; Naloxone; Naltrexone; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2020 |
Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Formaldehyde; Humans; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociception; Nociceptors; Pain; Pain Measurement | 2020 |
Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia.
Topics: Animals; Arginine; Brain; Disease Models, Animal; Empathy; Female; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociception; Pain; Rats, Wistar | 2020 |
The antinociceptive mechanisms of melatonin: role of L-arginine/nitric oxide/cyclic GMP/KATP channel signaling pathway.
Topics: Analgesics; Animals; Animals, Outbred Strains; Arginine; Cyclic GMP; KATP Channels; Male; Melatonin; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Signal Transduction | 2020 |
Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio).
Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Camphor; Capsaicin; Combretum; Dose-Response Relationship, Drug; Female; Ketamine; Locomotion; Male; Methylene Blue; Naloxone; NG-Nitroarginine Methyl Ester; Nociception; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Receptors, N-Methyl-D-Aspartate; Ruthenium Red; Triterpenes; TRPV Cation Channels; Zebrafish; Zebrafish Proteins | 2020 |
Role of l-arginine/SNAP/NO/cGMP/K
Topics: Analgesics; Animals; Arginine; Cyclic GMP; Cyclohexane Monoterpenes; Cyclohexenes; Dose-Response Relationship, Drug; KATP Channels; Male; Mice; Monoterpenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Treatment Outcome | 2018 |
Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling.
Topics: Animals; Anti-Inflammatory Agents; Arginine; Carrageenan; Dizocilpine Maleate; Edema; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2019 |
Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2.
Topics: Animals; Enzyme Inhibitors; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Pain; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine | 2014 |
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Formaldehyde; Hot Temperature; Hyperalgesia; Indazoles; Male; Mice; Modafinil; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain | 2014 |
Nitric oxide synthase modulates the antihyperalgesic effect of the NMDA receptor antagonist MK-801 on Carrageenan-induced inflammatory pain in rats.
Topics: Animals; Arginine; Carrageenan; Dizocilpine Maleate; Hyperalgesia; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2014 |
Antinociceptive effect and mechanism of action of isatin, N-methyl isatin and oxopropyl isatin in mice.
Topics: Analgesics; Animals; Atropine; Dose-Response Relationship, Drug; Isatin; Mecamylamine; Mice; Morphine; Naloxone; NG-Nitroarginine Methyl Ester; Ondansetron; Pain; Pain Measurement | 2016 |
Involvement of spinal nitric oxide (NO) in rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch.
Topics: Animals; Gene Expression Regulation, Enzymologic; Genes, fos; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Scorpion Venoms; Spinal Cord | 2008 |
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; beta-Endorphin; Citrulline; Dynorphins; Enkephalin, Methionine; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraperitoneal; Male; Mice; Microinjections; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Thiourea | 2009 |
Reactive oxygen species in rats with chronic post-ischemia pain.
Topics: Allopurinol; Animals; Chronic Disease; Cold Temperature; Enzyme Inhibitors; Free Radical Scavengers; Ischemia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Xanthine Oxidase | 2009 |
Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice.
Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Animal; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Hot Temperature; Injections, Intraperitoneal; Lauraceae; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Reaction Time; Time Factors; Tyramine | 2009 |
Role of nitric oxide in the rat hippocampal CA1 in morphine antinociception.
Topics: Analgesics, Opioid; Animals; Arginine; CA1 Region, Hippocampal; Central Nervous System Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Inflammation; Male; Morphine; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors | 2010 |
Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation.
Topics: Animals; Cyclic GMP; Female; Freund's Adjuvant; Glyburide; Hyperalgesia; Inflammation; KATP Channels; Male; Methanol; Mice; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Phytotherapy; Plant Extracts; Plant Roots | 2010 |
Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice.
Topics: Acetic Acid; Animals; Behavior, Animal; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraventricular; Male; Mice; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement | 2010 |
Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior.
Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Benzoates; Cyclic AMP-Dependent Protein Kinases; Cyclic N-Oxides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Glycine; Inositol 1,4,5-Trisphosphate; Macrocyclic Compounds; Mitochondria; Neurons; NG-Nitroarginine Methyl Ester; Oxazoles; Pain; Pain Measurement; Pain Perception; Patch-Clamp Techniques; Pyridines; Reactive Oxygen Species; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; Spin Labels; Superoxides; Thiazoles; Vocalization, Animal | 2011 |
Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation.
Topics: Analgesics, Opioid; Animals; Control Groups; Disks Large Homolog 4 Protein; Enzyme Inhibitors; Guanylate Kinases; Hyperalgesia; Injections, Spinal; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Spinal Cord | 2011 |
The acute effects of mirtazapine on pain related behavior in healthy animals.
Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyproheptadine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Hippocampus; In Vitro Techniques; Male; Mianserin; Mice; Mirtazapine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin Antagonists | 2011 |
[Effects of nitric oxide on spontaneous pain reaction and neuronal apoptosis in the spinal cord of rats induced by formalin inflammatory pain].
Topics: Animals; Apoptosis; Formaldehyde; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2011 |
Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
Topics: Acetic Acid; Administration, Oral; Animals; Asteraceae; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Cytokines; Diterpenes; Dose-Response Relationship, Drug; Formaldehyde; Freund's Adjuvant; Glyburide; Inflammation; Injections, Intraperitoneal; Interleukin-8; KATP Channels; Mice; Molecular Structure; NG-Nitroarginine Methyl Ester; Pain; Tumor Necrosis Factor-alpha | 2012 |
Intrathecal clonidine decreases spinal nitric oxide release in a rat model of complete Freund's adjuvant induced inflammatory pain.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Enzyme Inhibitors; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Idazoxan; Injections, Spinal; Male; Myelitis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord | 2002 |
Sildenafil, a phosphodiesterase-5 inhibitor, enhances the antinociceptive effect of morphine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Hyperalgesia; Male; Methylene Blue; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones; Time Factors | 2003 |
Involvement of nitric oxide in the nociception of kyotorphin, TYR-CAV and MIF-s analogues in the rat spinal cord.
Topics: Acute Disease; Analgesics; Animals; Drug Interactions; Drug Synergism; Endorphins; Injections, Spinal; Male; MSH Release-Inhibiting Hormone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Threshold; Rats; Rats, Wistar; Spinal Cord; Time Factors | 2003 |
Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase.
Topics: Animals; Behavior, Animal; Blotting, Western; Carrageenan; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Inflammation; Injections, Spinal; Lumbosacral Region; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pain; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Time Factors | 2003 |
[Microinjection of L-NAME into dorsal raphe nucleus inhibits nociceptive response in sigmoid pain model of rats].
Topics: Analgesics; Animals; Genes, fos; Microinjections; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptors; Pain; Pain Measurement; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Sigmoid Diseases | 2003 |
Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Synergism; Enzyme Inhibitors; Extracellular Fluid; Formaldehyde; Glutamic Acid; Injections, Spinal; Male; Microdialysis; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord | 2003 |
Modulatory effect of cyclooxygenase inhibitors on sildenafil-induced antinociception.
Topics: Animals; Carrageenan; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Synergism; Enzyme Inhibitors; Female; Male; Mice; NG-Nitroarginine Methyl Ester; Pain; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfonamides; Sulfones | 2003 |
Participation of the NO-cyclic GMP pathway in rofecoxib-induced antinociception.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Isoenzymes; Lactones; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Sulfones; Uric Acid | 2003 |
Agmatine-morphine interaction on nociception in mice.
Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Interactions; Enzyme Inhibitors; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement | 2003 |
Cholinergic-NO-cGMP mediation of sildenafil-induced antinociception.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Acetylcholine; Animals; Carrageenan; Cholinergic Agents; Cholinesterase Inhibitors; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Female; Guanylate Cyclase; Hyperalgesia; Male; Methylene Blue; Mice; Neostigmine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones | 2004 |
Acute and delayed restraint stress-induced changes in nitric oxide producing neurons in limbic regions.
Topics: Animals; Enzyme Inhibitors; Immunohistochemistry; Injections, Intraventricular; Limbic System; Male; Microinjections; NADPH Dehydrogenase; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Rats; Rats, Wistar; Reaction Time; Restraint, Physical; Stress, Psychological | 2004 |
Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury.
Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrobenzenes; Pain; Pain Threshold; Piroxicam; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sulfonamides | 2004 |
Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Chronic Disease; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Female; Gout; Indomethacin; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Pain; Pain Measurement; Peripheral Nervous System; Rats; Rats, Wistar; Signal Transduction; Uric Acid | 2004 |
Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.
Topics: Analgesics; Animals; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Glyburide; Guanylate Cyclase; Hindlimb; Injections, Spinal; Injections, Subcutaneous; Methiothepin; Naloxone; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organic Chemicals; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Scorpion Venoms | 2005 |
Modification by L-NAME of codeine induced analgesia: possible role of nitric oxide.
Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Codeine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Male; Mice; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Nitroprusside; Pain; Time Factors | 2004 |
Involvement of N-methyl-D-aspartate receptors and nitric oxide in the rostral ventromedial medulla in modulating morphine pain-inhibitory signals from the periaqueductal grey matter in rats.
Topics: Analgesics, Opioid; Animals; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Male; Medulla Oblongata; Microinjections; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2005 |
Involvement of nitric oxide in clonidine-induced spinal analgesia.
Topics: Acute Disease; Analgesia; Analgesics; Animals; Arginine; Clonidine; Injections, Spinal; Male; Methylene Blue; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pain | 2005 |
Cerebroventricular injection of clonidine causes analgesia mediated by a nitrogen pathway.
Topics: Acute Disease; Analgesia; Analgesics; Animals; Arginine; Cerebral Ventricles; Clonidine; Injections; Male; Methylene Blue; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pain; Random Allocation | 2005 |
Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice.
Topics: Analysis of Variance; Animals; Arginine; Blotting, Western; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Reaction Time; Spinal Cord; Time Factors; Vincristine | 2005 |
Peripheral participation of the phosphodiesterase 3 on formalin-evoked nociception.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Injections, Subcutaneous; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Tetrahydroisoquinolines; Time Factors | 2005 |
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide | 2005 |
Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.
Topics: Analgesia; Animals; Blood Glucose; Body Weight; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Streptozocin; Sulfones; Time Factors | 2005 |
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
Topics: Animals; Anti-Bacterial Agents; Antibodies, Blocking; Chemokine CX3CL1; Chemokines, CX3C; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Injections, Spinal; Interleukin-6; Male; Membrane Proteins; Microglia; Microinjections; Minocycline; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord | 2005 |
[Change in pain reaction by combined action of nitric oxide modulators and low intensity electromagnetic field].
Topics: Animals; Animals, Outbred Strains; Combined Modality Therapy; Electromagnetic Fields; Enzyme Inhibitors; Formaldehyde; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pain; Pain Management; Pain Threshold; Sodium Nitrite | 2005 |
The involvement of nitric oxide on the analgesic effect of tramadol.
Topics: Analgesics; Analgesics, Opioid; Animals; Drug Synergism; Female; Indazoles; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Tramadol | 2006 |
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents | 2006 |
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hyperalgesia; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Pain; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley | 2006 |
Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not L-NAME, on the in vitro neonatal rat spinal cord preparation.
Topics: Afferent Pathways; Animals; Animals, Newborn; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Ketamine; Ketoprofen; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Culture Techniques; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission | 2006 |
Attenuation of morphine tolerance and dependence by aminoguanidine in mice.
Topics: Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Animal; Brain; Dizocilpine Maleate; Drug Tolerance; Enzyme Inhibitors; Glutamates; Guanidines; Male; Mice; Morphine; Morphine Dependence; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Pain; Pain Measurement; Time Factors | 2006 |
Sildenafil induces hyperalgesia via activation of the NO-cGMP pathway in the rat neuropathic pain model.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Chronic Disease; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Threshold; Piperazines; Purines; Rats; Rats, Wistar; Sciatic Neuropathy; Signal Transduction; Sildenafil Citrate; Sulfones | 2006 |
The antinociceptive activity of Muntingia calabura aqueous extract and the involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its observed activity in mice.
Topics: Acetic Acid; Analgesics; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Elaeocarpaceae; Enzyme Inhibitors; Guanylate Cyclase; Male; Methylene Blue; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Signal Transduction | 2006 |
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: possible mechanisms.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Capsaicin; Coloring Agents; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; KATP Channels; Lamiaceae; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Oleanolic Acid; Pain; Pain Measurement; Postural Balance; Potassium Channels, Inwardly Rectifying; Ruthenium Red; Yohimbine | 2006 |
Roles of nitric oxide synthase inhibitor on antinociceptive effects of mu-opioid agonist in mice.
Topics: Analgesics; Animals; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oligopeptides; Pain; Receptors, Opioid, mu | 2006 |
Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior.
Topics: Amidines; Analgesics, Opioid; Animals; Behavior, Animal; Benzylamines; Blotting, Western; Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Indazoles; Injections, Spinal; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitriles; Nociceptors; Pain; Signal Transduction | 2007 |
Somatosensory pain does not affect total cerebral blood volume.
Topics: Animals; Brain; Cerebrovascular Circulation; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Rats; Rats, Wistar; Regional Blood Flow; Sciatic Nerve | 2007 |
Role of NO/cGMP/KATP pathway in antinociceptive effect of sildenafil in zymosan writhing response in mice.
Topics: Analgesics; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain; Piperazines; Potassium Channels; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones; Zymosan | 2007 |
Twenty-four-hour variation of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway demonstrated by the mouse visceral pain model.
Topics: Abdominal Pain; Analgesics; Animals; Arginine; Benzoquinones; Circadian Rhythm; Cyclic GMP; Enzyme Inhibitors; Male; Methylene Blue; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroprusside; Pain; Pain Measurement; Signal Transduction | 2007 |
TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues.
Topics: Animals; Calibration; Ganglia; Models, Biological; Morphine; Mytilus edulis; Naloxone; Nervous System; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Opioid Peptides; Pain; Signal Transduction; Transcutaneous Electric Nerve Stimulation | 2007 |
Antinociceptive effect from Davilla elliptica hydroalcoholic extract.
Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Brazil; Cyclooxygenase Inhibitors; Diclofenac; Dilleniaceae; Enzyme Inhibitors; Ethanol; Formaldehyde; Hindlimb; Male; Medicine, Traditional; Mice; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Plant Components, Aerial; Plant Extracts; Water | 2007 |
Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice.
Topics: Analgesics, Opioid; Animals; Cytokines; DNA Damage; Drug Tolerance; Enzyme Inhibitors; Free Radical Scavengers; Humans; Male; Metalloporphyrins; Mice; NG-Nitroarginine Methyl Ester; Pain; Pain Threshold; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Porphyrins; Rats; Spinal Cord; Superoxide Dismutase; Tyrosine | 2007 |
Role of nitric oxide/cyclic GMP/K(+) channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol.
Topics: Analgesics; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Formaldehyde; Glutamic Acid; Glyburide; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organoselenium Compounds; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Potassium Channels; Rats; Rats, Wistar; Serotonin; Signal Transduction | 2007 |
Systemic N-nitro-L-arginine-ester (L-NAME), inhibitor of nitric oxide synthase, relieves chronic allodynia-like symptom in rats with spinal cord lesion.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Female; Injections, Intraperitoneal; Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Palliative Care; Pressure; Rats; Rats, Sprague-Dawley; Spinal Cord | 1994 |
Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation.
Topics: Administration, Topical; Amino Acid Oxidoreductases; Animals; Arginine; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Stereoisomerism | 1994 |
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P | 1994 |
Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F2 alpha in conscious mice.
Topics: Analysis of Variance; Animals; Arginine; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Injections, Spinal; Male; Methylene Blue; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1995 |
L-NG-nitro arginine p-nitroanilide (L-NAPNA) is anti-nociceptive in the mouse.
Topics: Amino Acid Oxidoreductases; Analgesics; Anilides; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Brain; Formaldehyde; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Pain; Rabbits; Rats; Rats, Sprague-Dawley | 1993 |
Nitric oxide mediates neuropathic pain behavior in peripherally denervated rats.
Topics: Animals; Arginine; Behavior, Animal; Cyclic AMP; Denervation; Disease Models, Animal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Peripheral Nerves; Phantom Limb; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Stereoisomerism; Synaptic Transmission; Time Factors | 1995 |
Analysis of the role of endothelin-A and endothelin-B receptors on nociceptive information transmission in the spinal cord with FR139317, an endothelin-A receptor antagonist, and sarafotoxin S6c, an endothelin-B receptor agonist.
Topics: Animals; Arginine; Azepines; Behavior, Animal; Endothelin Receptor Antagonists; Endothelins; Formaldehyde; Indoles; Male; NG-Nitroarginine Methyl Ester; Pain; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Viper Venoms | 1994 |
Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats.
Topics: Analgesics; Animals; Arginine; Behavior, Animal; Formaldehyde; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord | 1993 |
Application of nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats.
Topics: Animals; Enzyme Inhibitors; Free Radicals; Hot Temperature; Hyperalgesia; Ligation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve | 1996 |
L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2.
Topics: Animals; Arginine; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Pain; Spinal Cord | 1995 |
Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw.
Topics: Animals; Enzyme Induction; Foot; Formaldehyde; Injections; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Up-Regulation | 1996 |
Antinociceptive synergistic interaction between morphine and n omega-nitro 1-arginine methyl ester on thermal nociceptive tests in the rats.
Topics: Analgesics, Opioid; Animals; Drug Synergism; Enzyme Inhibitors; Male; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Rats; Rats, Wistar | 1996 |
Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors.
Topics: Adrenergic Agonists; Analgesics; Animals; Arousal; Blood Pressure; Chronic Disease; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Female; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Physical Stimulation; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries | 1996 |
Characterization of nociceptin hyperalgesia and allodynia in conscious mice.
Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Receptors, GABA; Receptors, Glycine; Receptors, Opioid | 1997 |
Nitric oxide is not involved in vascular nociception of noxious physical stimuli in humans.
Topics: Adult; Blood Vessels; Humans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Physical Stimulation | 1997 |
Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord.
Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Spinal Cord | 1997 |
Involvement of nitric oxide and serotonin in modulation of antinociception and pressor responses evoked by stimulation in the dorsolateral region of the periaqueductal gray matter in the rat.
Topics: Animals; Blood Pressure; Brain Mapping; Electric Stimulation; Hot Temperature; Interneurons; Male; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Serotonin; Stereoisomerism | 1997 |
Rapid development of nitric oxide-induced hyperalgesia depends on an alternate to the cGMP-mediated pathway in the rat neuropathic pain model.
Topics: Animals; Antidotes; Cyclic GMP; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hemoglobins; Hot Temperature; Hyperalgesia; Ligation; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord | 1998 |
Circadian-rhythm-dependent effects of L-NG-nitroarginine methyl ester (L-NAME) on morphine-induced analgesia.
Topics: Analgesia; Animals; Circadian Rhythm; Drug Interactions; Enzyme Inhibitors; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Pain Measurement | 1998 |
The role of nitric oxide in neuropathic pain and neurodegeneration.
Topics: Analgesics; Animals; Disease Models, Animal; Enzyme Inhibitors; Nerve Degeneration; Nervous System Diseases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Receptors, N-Methyl-D-Aspartate | 1998 |
Cyclic GMP pathway is critical for inducing long-term sensitization of nociceptive sensory neurons.
Topics: Animals; Aplysia; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Ganglia, Invertebrate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Physical Stimulation; Protein Kinases; Time Factors; Transcription, Genetic | 1999 |
Acetazolamide and amiloride inhibit pentobarbital-induced facilitation of nocifensive reflexes.
Topics: Acetazolamide; Amiloride; Animals; GABA Modulators; Male; NG-Nitroarginine Methyl Ester; Pain; Pentobarbital; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Reflex | 1999 |
Antinociception after both peripheral and intrathecal injection of oxotremorine is modulated by spinal nitric oxide.
Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Intraperitoneal; Injections, Spinal; Male; Molsidomine; Muscarinic Agonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nociceptors; Oxotremorine; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord | 1999 |
Antinociceptive properties and nitric oxide synthase inhibitory action of new ruthenium complexes.
Topics: Analgesics; Animals; Blood Pressure; Drug Interactions; Enzyme Inhibitors; Isoenzymes; Male; Mice; Motor Activity; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Pain; Rabbits; Rats; Rats, Wistar; Ruthenium Compounds; Structure-Activity Relationship | 1999 |
Antinociceptive mechanism of Gosha-jinki-gan in streptozotocin-induced diabetic animals: role of nitric oxide in the periphery.
Topics: Analgesics; Animals; Arginine; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Enzyme Inhibitors; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Tail | 1999 |
L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception.
Topics: Acetic Acid; Analgesics; Animals; Buspirone; Cholinergic Agents; Drug Synergism; Enzyme Inhibitors; Female; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan | 1999 |
Hyperactivity caused by a nitric oxide synthase inhibitor is countered by ultra-wideband pulses.
Topics: Analysis of Variance; Animals; Electromagnetic Fields; Enzyme Inhibitors; Hyperkinesis; Injections, Intraperitoneal; Locomotion; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptors; Pain; Pain Threshold; Reaction Time; Sodium Chloride; Time Factors | 1999 |
Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test.
Topics: Analgesics, Non-Narcotic; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Meloxicam; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Thiazines; Thiazoles | 2000 |
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indomethacin; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors | 2000 |
Role of guanylyl cyclase activation via thiamine in suppressing chemically-induced writhing in mouse.
Topics: Animals; Arginine; Benzoquinones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Thiamine | 2000 |
Opposing interplay between Neuropeptide FF and nitric oxide in antinociception and hypothermia.
Topics: Analgesics, Opioid; Animals; Area Under Curve; Arginine; Body Temperature; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Hypothermia; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Pain; Temperature | 2000 |
How central is nitric oxide (NO) to the activation of c-fos in spinal neurones following noxious peripheral stimulation in the rat?
Topics: Animals; Enzyme Inhibitors; Female; Male; Mustard Plant; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Noxae; Pain; Peripheral Nerves; Plant Extracts; Plant Oils; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Spinal Cord | 2001 |
Antinociceptive effect of spinally injected L-NAME on the acute nociceptive response induced by low concentrations of formalin.
Topics: Analgesics; Animals; Enzyme Inhibitors; Formaldehyde; Injections, Spinal; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain | 2001 |
Potentiation by nitric oxide synthase inhibitor and calcium channel blocker of aspartame-induced antinociception in the mouse formalin test.
Topics: Analgesics; Animals; Aspartame; Calcium Channel Blockers; Drug Synergism; Enzyme Inhibitors; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Verapamil | 2001 |
Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Analgesia; Animals; Arginine; Carrageenan; Central Nervous System; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Nociceptors; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Sulfones | 2001 |
Participation of the nitric oxide-cyclic GMP-ATP-sensitive K(+) channel pathway in the antinociceptive action of ketorolac.
Topics: Adenosine Triphosphate; Analgesics; Animals; Behavior, Animal; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glyburide; Guanylate Cyclase; Ketorolac; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Penicillamine; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Signal Transduction | 2001 |
Dual effect of nitric oxide in articular inflammatory pain in zymosan-induced arthritis in rats.
Topics: Amidines; Animals; Arthritis, Experimental; Benzylamines; Cartilage, Articular; Dinoprost; Edema; Enzyme Inhibitors; Guanidines; Injections, Intra-Articular; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pain; Pain Measurement; Rats; Rats, Wistar; Zymosan | 2002 |
Increase of nitric oxide production by L-arginine potentiates i.c.v. administered beta-endorphin-induced antinociception in the mouse.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; beta-Endorphin; Drug Synergism; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain | 1992 |
Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse.
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Blood Pressure; Drug Synergism; Flurbiprofen; Formaldehyde; Indomethacin; Male; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Pain | 1992 |
Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
Topics: Analysis of Variance; Animals; Arginine; Hot Temperature; Hyperalgesia; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1992 |
L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse.
Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Blood Pressure; Brain Chemistry; Edema; Formaldehyde; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain | 1991 |
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalgesia; Indoles; Ligation; Neuralgia; Nitric Oxide Synthase Type I; Pain; Pyridines; Spinal Nerves; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vascular Resistance; Vasoconstriction | 2011 |