Page last updated: 2024-08-23

ng-nitroarginine methyl ester and Ache

ng-nitroarginine methyl ester has been researched along with Ache in 112 studies

Research

Studies (112)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's32 (28.57)18.2507
2000's55 (49.11)29.6817
2010's16 (14.29)24.3611
2020's9 (8.04)2.80

Authors

AuthorsStudies
Abbaszadeh, F; Fakhri, S; Farzaei, MH; Mohammadi, S; Mohammadi-Farani, A1
Hashemi, M; Karami, M; Zarrindast, M1
Flores-Murrieta, FJ; Gonzalez-Cortazar, M; Herrera-Ruiz, ML; Juárez-Aragón, MC; Molina-Cabrera, J; Montiel-Ruiz, RM; Vargas-Ruiz, R; Zamilpa, A1
Chen, YW; Chou, AK1
Arslan, G; Demirkazik, A; Ozdemir, E; Pelit, A; Taskiran, AS1
Capim, SL; Côrtes, WDS; Gonçalves, GM; Laureano-Melo, R; Marinho, BG; Oliveira, PA; Vasconcellos, MLAA1
Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Sotomayor-Zárate, R1
Ahmadi-Zeidabadi, M; Jeddi, S; Kohlmeier, KA; Mohammadi, F; Shabani, M1
Abbaszadeh, F; Ahmadpour, Y; Fakhri, S; Ghanbarveisi, F; Gravandi, MM; Iranpanah, A; Kooshki, L; Moradi, SZ; Rezaei, H1
Bandeira, PN; Campos, AR; da Silva, AW; de Menezes, JESA; Dos Reis Lima, J; Dos Santos, HS; Evaristo, FFV; Ferreira, MKA; Holanda, CLA; Magalhães, FEA; Silva, FCO; Teixeira, EH1
Fouladzadeh, A; Ghafghazi, S; Moghimi, M; Nemati, Y; Parvardeh, S; Safaripour, S1
Milovanović, A; Prostran, M; Srebro, DP; Vučetić, Č; Vučković, S; Vujović, KS1
Antunes, E; Camargo, EA; Costa, SK; Cotrim, C; Landucci, EC; Muscara, MN; Santana, DG; Silva, CI; Teixeira, SA; Toyama, MH1
Bhattacharya, SK; Gupta, LK; Gupta, R1
Prostran, MS; Savic Vujovic, KR; Srebro, DP; Vucković, SM1
Fernandes, PD; Giorno, TBS; Pinto, ADC; Silva, BVD1
Ji, YH; Jiang, F; Liu, T; Pang, XY1
Chung, E; Ohgami, Y; Quock, RM; Shirachi, DY; Zelinski, LM2
Baek, WY; Han, CG; Hong, JG; Jeon, Y; Kim, SO; Kwak, KH; Lee, SH; Lim, DG; Park, SS1
Amaral, JF; Araújo, FL; Barbosa-Filho, JM; de Sousa, FC; Gutierrez, SJ; Leite, CP; Melo, CT; Moura, BA; Rocha, NF; Vasconcelos, SM; Viana, GS1
Hashemi, M; Karami, M; Sahebgharani, M; Zarrindast, MR1
Andrade, EL; Calixto, JB; Dutra, RC; Nguelefack, TB; Paszcuk, AF; Tapondjou, LA1
Ji, G; Li, Z; Neugebauer, V1
Beitz, AJ; Choi, SR; Han, HJ; Kang, SY; Kwon, SG; Lee, JH; Moon, JY; Roh, DH; Yoon, SY1
Baydemir, C; Dogan, AE; Erol, K; Kilic, FS1
Chu, SC; Hu, YY; Li, HN; Li, QJ; Li, WB1
Ambrosio, SR; Arakawa, NS; Casagrande, R; Cunha, FQ; Cunha, TM; Ferreira, SH; Mizokami, SS; Verri, WA; Zarpelon, AC1
Cheng, JT; Chuang, YC; Lin, CR; Wang, CJ; Yang, LC1
Jain, NK; Kulkarni, SK; Patil, CS; Singh, A3
Bocheva, A; Lazarova, M1
Johns, RA; Li, D; Liaw, WJ; Mao, P; Raja, SN; Tao, F; Tao, YX; Zhao, C1
Yang, B; Zeng, YM; Zhang, LC1
Ando, R; Okuda, K; Sakurada, C; Sakurada, S; Sakurada, T; Watanabe, C1
Déciga-Campos, M; López-Muñoz, FJ1
Llorente, J; Pineda, J; Ruiz-Durantez, E; Ugedo, L; Ulibarri, I1
Jain, NK; Kulkarni, SK; Patil, CS; Singh, VP1
Del Bel, EA; Echeverry, MB; Guimarães, FS1
Lee, CH; Lui, PW1
Déciga-Campos, M; Díaz-Reval, MI; González-Trujano, ME; López-Muñoz, FJ; Ventura-Martínez, R1
Castañeda-Hernández, G; Granados-Soto, V; Lozano-Cuenca, J1
Al-Shabanah, OA; El-Hadiyah, TM; Khattab, MM; Raza, M1
Dehpour, AR; Javanmardi, K; Keshavarz, M; Minaii, B; Parviz, M; Sadr, SS1
Aronov, S; Ben-Abraham, R; Givati-Divshi, D; Katz, Y2
Kamei, J; Saitoh, A; Tamura, N1
Granados-Soto, V; Torres-López, JE1
Honda, M; Ono, H; Sakaue, A; Takasu, K; Tanabe, M1
Araiza-Saldaña, CI; Bermúdez-Ocaña, DY; Granados-Soto, V; Pérez-Severiano, F; Reyes-García, G1
Chacur, M; Green, P; Maier, SF; Martin, D; Milligan, E; Poole, S; Schoeniger, D; Watkins, LR; Zapata, V1
Lymans'kyĭ, IuP; Sushko, BS1
Aypar, U; Dal, D; Iskit, AB; Salman, AE; Salman, MA1
Flores-Murrieta, FJ; Granados-Soto, V; Mixcoatl-Zecuatl, T1
Greco, R; Nappi, G; Sandrini, G; Tassorelli, C; Wang, D1
Chambers, JP; Johnson, CB; Lizarraga, I1
Abdel-Hady, RH; Abdel-Rahman, S; Abdel-Zaher, AO; Aly, SA; Hamdy, MM1
Kulkarni, SK; Padi, SV; Patil, CS; Singh, VP1
Abdullah, FC; Balakhrisnan, G; Jais, AM; Jayaraman, KV; Somchit, MN; Sulaiman, MR; Zakaria, ZA1
Campos, AR; David, JM; David, JP; Lima-Júnior, RC; Maia, JL; Melo, CM; Rao, VS; Santos, FA1
Chena, LX; Duan, X; Gao, YF; Qia, YM; Wangb, R; Yang, DJ1
Bagetta, G; Komatsu, T; Sakurada, C; Sakurada, S; Sakurada, T; Sanai, K; Sasaki, M; Tsuzuki, M1
Erdos, B; Komjáti, K; Lacza, Z; Mersich, T; Sándor, P; Szelke, E1
Cavalcante, IF; Ribeiro, RA; Rolim, DE; Souza, MH; Vale, ML1
Abacioglu, N; Altug, S; Tunctan, B; Uludag, O; Zengil, H1
Cheng, J; Han, JS; Kream, RM; Stefano, GB; Zhang, C1
Azevedo, AO; Braga, FC; Campos, JJ; Duarte, ID; Galdino, GS; Perez, AC1
Cuzzocrea, S; Esposito, E; Fabrizi, F; Masini, E; Matuschak, GM; Mollace, V; Muscoli, C; Ndengele, MM; Porreca, F; Salvemini, D1
Jesse, CR; Nogueira, CW; Savegnago, L1
Hao, JX; Wiesenfeld-Hallin, Z; Xu, XJ1
Kawabata, A; Manabe, S; Manabe, Y; Takagi, H1
Coderre, TJ; Yashpal, K1
Hayaishi, O; Hyodo, M; Ito, S; Minami, T; Nishihara, I; Sakamoto, K1
Babbedge, RC; Gaffen, ZA; Hart, SL; Moore, PK; Wallace, P1
Feria, M; Niedbala, B; Sánchez, A1
Asano, H; Mizuguchi, T; Shimoyama, N; Yamamoto, T1
Malmberg, AB; Yaksh, TL1
Besse, D; Dubner, R; Ren, K; Ruda, MA; Thomas, DA1
Hayaishi, O; Ito, S; Minami, T; Mori, H; Okuda-Ashitaka, E; Onaka, M1
Dawson, TM; Hanley, DF; Lam, HH; Raja, S; Saito, S; Trapp, BD; Yamaguchi, H1
Naito, H; Yamaguchi, H1
Hao, JX; Xu, XJ1
Hara, N; Imanishi, T; Ito, S; Minami, T; Mori, H; Okuda-Ashitaka, E; Onaka, M; Sakai, M; Shingu, K; Sugimoto, T1
Ding, Z; Holthusen, H1
Labuz, D; Machelska, H; Przewłocka, B; Przewłocki, R1
Hämäläinen, MM; Lovick, TA1
Inoue, T; Mashimo, T; Shibata, M; Shibuta, S; Yoshiya, I1
Abacioğlu, N; Görgün, CZ; Güney, HZ; Hodoğlugil, U; Tunçtan, B; Uludağ, O; Zengil, H1
Gordh, T1
Lewin, MR; Walters, ET1
Archer, DP; Roth, SH1
Capone, F; Machelska, H; Pavone, F; Przewłocka, B1
Beirith, A; Bonetti, VR; Calixto, JB; Creczynski-Pasa, TB; Franco, CV; Konzen, M; Paula, MS; Seifriz, I1
Goto, K; Ishige, A; Kamei, J; Komatsu, Y; Suzuki, Y1
Jain, NK; Kulkarni, SK1
Belt, ML; Doyle, JM; Mathur, SP; Seaman, RL1
Aguirre-Bañuelos, P; Granados-Soto, V1
Huh, IH; Lee, TS; Park, YH; Shin, CY; Sohn, UD1
Abacioğlu, N; Cakici, I; Demir, S; Kanzik, I; Tunçtan, B1
Francés, B; Latapie, JP; Zajac, JM1
Hismiogullari, ES; Morris, R; Nazli, M; Thippeswamy, T1
Kisara, K; Nakayama, M; Sakurada, C; Sakurada, S; Sakurada, T; Sugiyama, A; Tan-No, K; Yonezawa, A1
Abdoli, N; Abdollahi, M; Nikfar, S1
Granados-Soto, V; Lázaro-Ibáñez, GG; Torres-López, JE1
da Rocha, FA; da S Rocha, JC; de A Ribeiro, R; de Q Cunha, F; Jancar, S; Peixoto, ME1
Chapman, V; Dickenson, A; Haley, J; Schachter, M1
Pieper, GM; Tseng, LF; Xu, JY1
Babbedge, RC; Gaffen, Z; Hart, SL; Moore, PK; Morgan, CV; Wallace, P1
Gebhart, GF; Maves, TJ; Meller, ST; Pechman, PS1
Babbedge, RC; Hart, SL; Moore, PK; Oluyomi, AO; Wallace, P1
Andrews, JS; Annedi, SC; Bunton, D; Christie, L; Lee, DK; Maddaford, SP; Mladenova, G; Porreca, F; Rakhit, S; Ramnauth, J; Zhang, D1

Reviews

1 review(s) available for ng-nitroarginine methyl ester and Ache

ArticleYear
Electrophysiological approaches to the study of bradykinin and nitric oxide in inflammatory pain.
    Agents and actions. Supplements, 1992, Volume: 38 ( Pt 2)

    Topics: Animals; Arginine; Bradykinin; Formaldehyde; Inflammation; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroarginine; Pain; Rats; Receptors, Bradykinin; Receptors, Neurotransmitter; Spinal Cord

1992

Other Studies

111 other study(ies) available for ng-nitroarginine methyl ester and Ache

ArticleYear
Astaxanthin engages the l-arginine/NO/cGMP/KATP channel signaling pathway toward antinociceptive effects.
    Behavioural pharmacology, 2021, 12-01, Volume: 32, Issue:8

    Topics: Analgesics; Animals; Arginine; Cyclic GMP; Disease Models, Animal; Dose-Response Relationship, Drug; Glyburide; KATP Channels; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Signal Transduction; Sildenafil Citrate; Xanthophylls

2021
The regulatory role of nitric oxide in morphine-induced analgesia in the descending path of pain from the dorsal hippocampus to the dorsolateral periaqueductal gray.
    European journal of pain (London, England), 2022, Volume: 26, Issue:4

    Topics: Analgesia; Animals; Hippocampus; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Periaqueductal Gray; Rats; Rats, Wistar

2022
Bio-guided study of the antinociceptive, anti-inflammatory, and free-radical scavenging capacity of the leaves of Rhus virens Lindh. ex A. Gray and its possible mechanism of antinociception.
    Journal of ethnopharmacology, 2023, Jan-10, Volume: 300

    Topics: Adenosine Triphosphate; Analgesics; Animals; Anti-Inflammatory Agents; Antioxidants; Bicuculline; Edema; Glyburide; Hexanes; Mice; Naloxone; NG-Nitroarginine Methyl Ester; Pain; Plant Extracts; Plant Leaves; Rhus

2023
N(Omega)-nitro-l-arginine methyl ester potentiates lidocaine analgesic and anaesthetic effect in rats.
    The Journal of pharmacy and pharmacology, 2023, Jan-31, Volume: 75, Issue:1

    Topics: Analgesics; Anesthetics; Animals; Lidocaine; NG-Nitroarginine Methyl Ester; Pain; Rats; Rats, Sprague-Dawley

2023
The effects of extremely low-frequency pulsed electromagnetic fields on analgesia in the nitric oxide pathway.
    Nitric oxide : biology and chemistry, 2019, 11-01, Volume: 92

    Topics: Analgesia; Animals; Arginine; Electromagnetic Fields; Injections, Intraperitoneal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Management; Pyrazoles; Pyridines; Rats; Rats, Wistar; Signal Transduction; Temperature

2019
Pharmacological evaluation underlying the antinociceptive activity of two new hybrids NSAIDs tetrahydropyran derivatives.
    Fundamental & clinical pharmacology, 2020, Volume: 34, Issue:3

    Topics: Adenosine Triphosphate; Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclic GMP; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Formaldehyde; Glyburide; Humans; Male; Mice; Naloxone; Naltrexone; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2020
Involvement of NO in Antinociception of NSAIDS in Murine Formalin Hind Paw Assay.
    Drug research, 2020, Volume: 70, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Formaldehyde; Humans; Indazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociception; Nociceptors; Pain; Pain Measurement

2020
Affective dimensions of pain and region -specific involvement of nitric oxide in the development of empathic hyperalgesia.
    Scientific reports, 2020, 06-23, Volume: 10, Issue:1

    Topics: Animals; Arginine; Brain; Disease Models, Animal; Empathy; Female; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociception; Pain; Rats, Wistar

2020
The antinociceptive mechanisms of melatonin: role of L-arginine/nitric oxide/cyclic GMP/KATP channel signaling pathway.
    Behavioural pharmacology, 2020, Volume: 31, Issue:8

    Topics: Analgesics; Animals; Animals, Outbred Strains; Arginine; Cyclic GMP; KATP Channels; Male; Melatonin; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Signal Transduction

2020
Antinociceptive activity of 3β-6β-16β-trihydroxylup-20 (29)-ene triterpene isolated from Combretum leprosum leaves in adult zebrafish (Danio rerio).
    Biochemical and biophysical research communications, 2020, 12-10, Volume: 533, Issue:3

    Topics: Acid Sensing Ion Channels; Amiloride; Analgesics; Animals; Camphor; Capsaicin; Combretum; Dose-Response Relationship, Drug; Female; Ketamine; Locomotion; Male; Methylene Blue; Naloxone; NG-Nitroarginine Methyl Ester; Nociception; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Receptors, N-Methyl-D-Aspartate; Ruthenium Red; Triterpenes; TRPV Cation Channels; Zebrafish; Zebrafish Proteins

2020
Role of l-arginine/SNAP/NO/cGMP/K
    The Journal of pharmacy and pharmacology, 2018, Volume: 70, Issue:4

    Topics: Analgesics; Animals; Arginine; Cyclic GMP; Cyclohexane Monoterpenes; Cyclohexenes; Dose-Response Relationship, Drug; KATP Channels; Male; Mice; Monoterpenes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; S-Nitroso-N-Acetylpenicillamine; Signal Transduction; Treatment Outcome

2018
Preventive treatment with dizocilpine attenuates oedema in a carrageenan model of inflammation: the interaction of glutamatergic and nitrergic signaling.
    Inflammopharmacology, 2019, Volume: 27, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Arginine; Carrageenan; Dizocilpine Maleate; Edema; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2019
Inhibition of inducible nitric oxide synthase-derived nitric oxide as a therapeutical target for acute pancreatitis induced by secretory phospholipase A2.
    European journal of pain (London, England), 2014, Volume: 18, Issue:5

    Topics: Animals; Enzyme Inhibitors; Hyperalgesia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Pain; Pancreas; Pancreatitis; Peroxidase; Phospholipases A2, Secretory; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Tyrosine

2014
Chronic administration of modafinil induces hyperalgesia in mice: reversal by L-NG-nitro-arginine methyl ester and 7-nitroindazole.
    European journal of pharmacology, 2014, Aug-05, Volume: 736

    Topics: Analgesics; Animals; Behavior, Animal; Benzhydryl Compounds; Central Nervous System Stimulants; Formaldehyde; Hot Temperature; Hyperalgesia; Indazoles; Male; Mice; Modafinil; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain

2014
Nitric oxide synthase modulates the antihyperalgesic effect of the NMDA receptor antagonist MK-801 on Carrageenan-induced inflammatory pain in rats.
    The Tohoku journal of experimental medicine, 2014, Volume: 234, Issue:4

    Topics: Animals; Arginine; Carrageenan; Dizocilpine Maleate; Hyperalgesia; Inflammation; Isothiuronium; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Rats, Wistar; Receptors, N-Methyl-D-Aspartate

2014
Antinociceptive effect and mechanism of action of isatin, N-methyl isatin and oxopropyl isatin in mice.
    Life sciences, 2016, Apr-15, Volume: 151

    Topics: Analgesics; Animals; Atropine; Dose-Response Relationship, Drug; Isatin; Mecamylamine; Mice; Morphine; Naloxone; NG-Nitroarginine Methyl Ester; Ondansetron; Pain; Pain Measurement

2016
Involvement of spinal nitric oxide (NO) in rat pain-related behaviors induced by the venom of scorpion Buthus martensi Karsch.
    Toxicon : official journal of the International Society on Toxinology, 2008, Volume: 52, Issue:1

    Topics: Animals; Gene Expression Regulation, Enzymologic; Genes, fos; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Pain; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Scorpion Venoms; Spinal Cord

2008
A prolonged nitric oxide-dependent, opioid-mediated antinociceptive effect of hyperbaric oxygen in mice.
    The journal of pain, 2009, Volume: 10, Issue:2

    Topics: Acetic Acid; Analgesia; Analysis of Variance; Animals; beta-Endorphin; Citrulline; Dynorphins; Enkephalin, Methionine; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraperitoneal; Male; Mice; Microinjections; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Thiourea

2009
Reactive oxygen species in rats with chronic post-ischemia pain.
    Acta anaesthesiologica Scandinavica, 2009, Volume: 53, Issue:5

    Topics: Allopurinol; Animals; Chronic Disease; Cold Temperature; Enzyme Inhibitors; Free Radical Scavengers; Ischemia; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Physical Stimulation; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury; Superoxide Dismutase; Xanthine Oxidase

2009
Antinociceptive effects of (O-methyl)-N-benzoyl tyramine (riparin I) from Aniba riparia (Nees) Mez (Lauraceae) in mice.
    Naunyn-Schmiedeberg's archives of pharmacology, 2009, Volume: 380, Issue:4

    Topics: Acetic Acid; Administration, Oral; Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Animal; Benzamides; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Hot Temperature; Injections, Intraperitoneal; Lauraceae; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Reaction Time; Time Factors; Tyramine

2009
Role of nitric oxide in the rat hippocampal CA1 in morphine antinociception.
    Brain research, 2010, Feb-08, Volume: 1313

    Topics: Analgesics, Opioid; Animals; Arginine; CA1 Region, Hippocampal; Central Nervous System Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Formaldehyde; Inflammation; Male; Morphine; NADPH Dehydrogenase; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Rats; Rats, Wistar; Time Factors

2010
Antinociceptive activities of the methanol extract of the bulbs of Dioscorea bulbifera L. var sativa in mice is dependent of NO-cGMP-ATP-sensitive-K(+) channel activation.
    Journal of ethnopharmacology, 2010, Apr-21, Volume: 128, Issue:3

    Topics: Animals; Cyclic GMP; Female; Freund's Adjuvant; Glyburide; Hyperalgesia; Inflammation; KATP Channels; Male; Methanol; Mice; Neuralgia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Phytotherapy; Plant Extracts; Plant Roots

2010
Hyperbaric oxygen treatment induces a 2-phase antinociceptive response of unusually long duration in mice.
    The journal of pain, 2010, Volume: 11, Issue:9

    Topics: Acetic Acid; Animals; Behavior, Animal; Enzyme Inhibitors; Hyperbaric Oxygenation; Injections, Intraventricular; Male; Mice; Naltrexone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement

2010
Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011, Jan-19, Volume: 31, Issue:3

    Topics: Amygdala; Analysis of Variance; Animals; Antioxidants; Benzoates; Cyclic AMP-Dependent Protein Kinases; Cyclic N-Oxides; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Extracellular Signal-Regulated MAP Kinases; Glycine; Inositol 1,4,5-Trisphosphate; Macrocyclic Compounds; Mitochondria; Neurons; NG-Nitroarginine Methyl Ester; Oxazoles; Pain; Pain Measurement; Pain Perception; Patch-Clamp Techniques; Pyridines; Reactive Oxygen Species; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Signal Transduction; Spin Labels; Superoxides; Thiazoles; Vocalization, Animal

2011
Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation.
    British journal of pharmacology, 2011, Volume: 163, Issue:8

    Topics: Analgesics, Opioid; Animals; Control Groups; Disks Large Homolog 4 Protein; Enzyme Inhibitors; Guanylate Kinases; Hyperalgesia; Injections, Spinal; Male; Membrane Proteins; Mice; Mice, Inbred ICR; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Phosphorylation; Protein Kinase C; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Spinal Cord

2011
The acute effects of mirtazapine on pain related behavior in healthy animals.
    Neurosciences (Riyadh, Saudi Arabia), 2011, Volume: 16, Issue:3

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Arginine; Behavior, Animal; Cyproheptadine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Gene Expression Regulation, Enzymologic; Hippocampus; In Vitro Techniques; Male; Mianserin; Mice; Mirtazapine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Serotonin Antagonists

2011
[Effects of nitric oxide on spontaneous pain reaction and neuronal apoptosis in the spinal cord of rats induced by formalin inflammatory pain].
    Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology, 2011, Volume: 27, Issue:3

    Topics: Animals; Apoptosis; Formaldehyde; Male; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord

2011
Kaurenoic acid from Sphagneticola trilobata Inhibits Inflammatory Pain: effect on cytokine production and activation of the NO-cyclic GMP-protein kinase G-ATP-sensitive potassium channel signaling pathway.
    Journal of natural products, 2012, May-25, Volume: 75, Issue:5

    Topics: Acetic Acid; Administration, Oral; Animals; Asteraceae; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Cytokines; Diterpenes; Dose-Response Relationship, Drug; Formaldehyde; Freund's Adjuvant; Glyburide; Inflammation; Injections, Intraperitoneal; Interleukin-8; KATP Channels; Mice; Molecular Structure; NG-Nitroarginine Methyl Ester; Pain; Tumor Necrosis Factor-alpha

2012
Intrathecal clonidine decreases spinal nitric oxide release in a rat model of complete Freund's adjuvant induced inflammatory pain.
    Inflammation, 2002, Volume: 26, Issue:4

    Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Enzyme Inhibitors; Freund's Adjuvant; Hot Temperature; Hyperalgesia; Idazoxan; Injections, Spinal; Male; Myelitis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord

2002
Sildenafil, a phosphodiesterase-5 inhibitor, enhances the antinociceptive effect of morphine.
    Pharmacology, 2003, Volume: 67, Issue:3

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Female; Hyperalgesia; Male; Methylene Blue; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones; Time Factors

2003
Involvement of nitric oxide in the nociception of kyotorphin, TYR-CAV and MIF-s analogues in the rat spinal cord.
    Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:2

    Topics: Acute Disease; Analgesics; Animals; Drug Interactions; Drug Synergism; Endorphins; Injections, Spinal; Male; MSH Release-Inhibiting Hormone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Threshold; Rats; Rats, Wistar; Spinal Cord; Time Factors

2003
Intact carrageenan-induced thermal hyperalgesia in mice lacking inducible nitric oxide synthase.
    Neuroscience, 2003, Volume: 120, Issue:3

    Topics: Animals; Behavior, Animal; Blotting, Western; Carrageenan; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Inflammation; Injections, Spinal; Lumbosacral Region; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pain; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Time Factors

2003
[Microinjection of L-NAME into dorsal raphe nucleus inhibits nociceptive response in sigmoid pain model of rats].
    Sheng li xue bao : [Acta physiologica Sinica], 2003, Oct-25, Volume: 55, Issue:5

    Topics: Analgesics; Animals; Genes, fos; Microinjections; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptors; Pain; Pain Measurement; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Sigmoid Diseases

2003
Evidence that nitric oxide-glutamate cascade modulates spinal antinociceptive effect of morphine: a behavioural and microdialysis study in rats.
    Brain research, 2003, Nov-14, Volume: 990, Issue:1-2

    Topics: Analgesics, Opioid; Animals; Behavior, Animal; Drug Synergism; Enzyme Inhibitors; Extracellular Fluid; Formaldehyde; Glutamic Acid; Injections, Spinal; Male; Microdialysis; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord

2003
Modulatory effect of cyclooxygenase inhibitors on sildenafil-induced antinociception.
    Pharmacology, 2003, Volume: 69, Issue:4

    Topics: Animals; Carrageenan; Cyclic GMP; Cyclooxygenase Inhibitors; Diclofenac; Drug Synergism; Enzyme Inhibitors; Female; Male; Mice; NG-Nitroarginine Methyl Ester; Pain; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfonamides; Sulfones

2003
Participation of the NO-cyclic GMP pathway in rofecoxib-induced antinociception.
    Proceedings of the Western Pharmacology Society, 2003, Volume: 46

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Cyclic GMP; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanylate Cyclase; Isoenzymes; Lactones; Molsidomine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Prostaglandin-Endoperoxide Synthases; Quinoxalines; Rats; Rats, Wistar; Sulfones; Uric Acid

2003
Agmatine-morphine interaction on nociception in mice.
    Annals of the New York Academy of Sciences, 2003, Volume: 1009

    Topics: Agmatine; Analgesia; Analgesics, Opioid; Animals; Drug Interactions; Enzyme Inhibitors; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement

2003
Cholinergic-NO-cGMP mediation of sildenafil-induced antinociception.
    Indian journal of experimental biology, 2004, Volume: 42, Issue:4

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Acetylcholine; Animals; Carrageenan; Cholinergic Agents; Cholinesterase Inhibitors; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Drug Combinations; Enzyme Inhibitors; Female; Guanylate Cyclase; Hyperalgesia; Male; Methylene Blue; Mice; Neostigmine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Purines; Rats; Sildenafil Citrate; Sulfones

2004
Acute and delayed restraint stress-induced changes in nitric oxide producing neurons in limbic regions.
    Neuroscience, 2004, Volume: 125, Issue:4

    Topics: Animals; Enzyme Inhibitors; Immunohistochemistry; Injections, Intraventricular; Limbic System; Male; Microinjections; NADPH Dehydrogenase; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Rats; Rats, Wistar; Reaction Time; Restraint, Physical; Stress, Psychological

2004
Preemptive effects of intrathecal cyclooxygenase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury.
    Life sciences, 2004, Oct-08, Volume: 75, Issue:21

    Topics: Animals; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Hindlimb; Hot Temperature; Hyperalgesia; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitrobenzenes; Pain; Pain Threshold; Piroxicam; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sulfonamides

2004
Peripheral involvement of the nitric oxide-cGMP pathway in the indomethacin-induced antinociception in rat.
    European journal of pharmacology, 2004, Oct-25, Volume: 503, Issue:1-3

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Chronic Disease; Cyclic GMP; Disease Models, Animal; Enzyme Inhibitors; Female; Gout; Indomethacin; Nerve Tissue Proteins; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitroprusside; Pain; Pain Measurement; Peripheral Nervous System; Rats; Rats, Wistar; Signal Transduction; Uric Acid

2004
Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib.
    European journal of pharmacology, 2005, Apr-18, Volume: 513, Issue:1-2

    Topics: Analgesics; Animals; Apamin; Behavior, Animal; Charybdotoxin; Diclofenac; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Glyburide; Guanylate Cyclase; Hindlimb; Injections, Spinal; Injections, Subcutaneous; Methiothepin; Naloxone; Neurotoxins; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organic Chemicals; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Scorpion Venoms

2005
Modification by L-NAME of codeine induced analgesia: possible role of nitric oxide.
    Receptors & channels, 2004, Volume: 10, Issue:5-6

    Topics: Analgesia; Analgesics; Analgesics, Opioid; Animals; Codeine; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Male; Mice; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitrites; Nitroprusside; Pain; Time Factors

2004
Involvement of N-methyl-D-aspartate receptors and nitric oxide in the rostral ventromedial medulla in modulating morphine pain-inhibitory signals from the periaqueductal grey matter in rats.
    Clinical and experimental pharmacology & physiology, 2005, Volume: 32, Issue:7

    Topics: Analgesics, Opioid; Animals; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Male; Medulla Oblongata; Microinjections; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Periaqueductal Gray; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Signal Transduction

2005
Involvement of nitric oxide in clonidine-induced spinal analgesia.
    Drug metabolism and drug interactions, 2005, Volume: 21, Issue:1

    Topics: Acute Disease; Analgesia; Analgesics; Animals; Arginine; Clonidine; Injections, Spinal; Male; Methylene Blue; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pain

2005
Cerebroventricular injection of clonidine causes analgesia mediated by a nitrogen pathway.
    Drug metabolism and drug interactions, 2005, Volume: 21, Issue:1

    Topics: Acute Disease; Analgesia; Analgesics; Animals; Arginine; Cerebral Ventricles; Clonidine; Injections; Male; Methylene Blue; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroglycerin; Pain; Random Allocation

2005
Possible involvement of the spinal nitric oxide/cGMP pathway in vincristine-induced painful neuropathy in mice.
    Pain, 2005, Volume: 117, Issue:1-2

    Topics: Analysis of Variance; Animals; Arginine; Blotting, Western; Cyclic GMP; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Reaction Time; Spinal Cord; Time Factors; Vincristine

2005
Peripheral participation of the phosphodiesterase 3 on formalin-evoked nociception.
    European journal of pharmacology, 2005, Sep-05, Volume: 519, Issue:1-2

    Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Injections, Subcutaneous; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Tetrahydroisoquinolines; Time Factors

2005
Centrally mediated antihyperalgesic and antiallodynic effects of zonisamide following partial nerve injury in the mouse.
    Naunyn-Schmiedeberg's archives of pharmacology, 2005, Volume: 372, Issue:2

    Topics: Animals; Antioxidants; Central Nervous System; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Hot Temperature; Hyperalgesia; Injections, Intraventricular; Injections, Spinal; Isoxazoles; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pain Threshold; Sciatic Nerve; Time Factors; Touch; Zonisamide

2005
Effect of diabetes on the mechanisms of intrathecal antinociception of sildenafil in rats.
    European journal of pharmacology, 2005, Dec-19, Volume: 527, Issue:1-3

    Topics: Analgesia; Animals; Blood Glucose; Body Weight; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Phosphodiesterase Inhibitors; Piperazines; Potassium Channel Blockers; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Streptozocin; Sulfones; Time Factors

2005
An initial investigation of spinal mechanisms underlying pain enhancement induced by fractalkine, a neuronally released chemokine.
    The European journal of neuroscience, 2005, Volume: 22, Issue:11

    Topics: Animals; Anti-Bacterial Agents; Antibodies, Blocking; Chemokine CX3CL1; Chemokines, CX3C; Enzyme Inhibitors; Hot Temperature; Hyperalgesia; Injections, Spinal; Interleukin-6; Male; Membrane Proteins; Microglia; Microinjections; Minocycline; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Pain Threshold; Physical Stimulation; Rats; Rats, Sprague-Dawley; Spinal Cord

2005
[Change in pain reaction by combined action of nitric oxide modulators and low intensity electromagnetic field].
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994), 2005, Volume: 51, Issue:5

    Topics: Animals; Animals, Outbred Strains; Combined Modality Therapy; Electromagnetic Fields; Enzyme Inhibitors; Formaldehyde; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Pain; Pain Management; Pain Threshold; Sodium Nitrite

2005
The involvement of nitric oxide on the analgesic effect of tramadol.
    European journal of anaesthesiology, 2006, Volume: 23, Issue:2

    Topics: Analgesics; Analgesics, Opioid; Animals; Drug Synergism; Female; Indazoles; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Tramadol

2006
The nitric oxide-cyclic GMP-protein kinase G-K+ channel pathway participates in the antiallodynic effect of spinal gabapentin.
    European journal of pharmacology, 2006, Feb-15, Volume: 531, Issue:1-3

    Topics: Amines; Analgesics; Animals; Apamin; Carbazoles; Charybdotoxin; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclohexanecarboxylic Acids; Diazoxide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Gabapentin; gamma-Aminobutyric Acid; Glyburide; Indazoles; Indoles; Injections, Spinal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Okadaic Acid; Oxadiazoles; Pain; Pinacidil; Potassium Channel Blockers; Potassium Channels; Protein Kinase Inhibitors; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Spinal Nerves; Stereoisomerism; Time Factors; Vasodilator Agents

2006
Prostaglandins, glutamate and nitric oxide synthase mediate nitroglycerin-induced hyperalgesia in the formalin test.
    European journal of pharmacology, 2006, Mar-18, Volume: 534, Issue:1-3

    Topics: Animals; Cyclooxygenase Inhibitors; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Formaldehyde; Glutamic Acid; Hyperalgesia; Indomethacin; Male; Models, Animal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroglycerin; Pain; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Rats; Rats, Sprague-Dawley

2006
Depression of NMDA-receptor-mediated segmental transmission by ketamine and ketoprofen, but not L-NAME, on the in vitro neonatal rat spinal cord preparation.
    Brain research, 2006, Jun-13, Volume: 1094, Issue:1

    Topics: Afferent Pathways; Animals; Animals, Newborn; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Ketamine; Ketoprofen; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Culture Techniques; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex; Spinal Cord; Spinal Nerve Roots; Synaptic Transmission

2006
Attenuation of morphine tolerance and dependence by aminoguanidine in mice.
    European journal of pharmacology, 2006, Jul-01, Volume: 540, Issue:1-3

    Topics: Analgesics; Analgesics, Opioid; Animals; Arginine; Behavior, Animal; Brain; Dizocilpine Maleate; Drug Tolerance; Enzyme Inhibitors; Glutamates; Guanidines; Male; Mice; Morphine; Morphine Dependence; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitrites; Pain; Pain Measurement; Time Factors

2006
Sildenafil induces hyperalgesia via activation of the NO-cGMP pathway in the rat neuropathic pain model.
    Inflammopharmacology, 2006, Volume: 14, Issue:1-2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Chronic Disease; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Hyperalgesia; Injections, Spinal; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Threshold; Piperazines; Purines; Rats; Rats, Wistar; Sciatic Neuropathy; Signal Transduction; Sildenafil Citrate; Sulfones

2006
The antinociceptive activity of Muntingia calabura aqueous extract and the involvement of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in its observed activity in mice.
    Fundamental & clinical pharmacology, 2006, Volume: 20, Issue:4

    Topics: Acetic Acid; Analgesics; Animals; Arginine; Cyclic GMP; Dose-Response Relationship, Drug; Elaeocarpaceae; Enzyme Inhibitors; Guanylate Cyclase; Male; Methylene Blue; Mice; Mice, Inbred BALB C; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; omega-N-Methylarginine; Pain; Pain Measurement; Plant Extracts; Plant Leaves; Signal Transduction

2006
Oleanolic acid, a pentacyclic triterpene attenuates capsaicin-induced nociception in mice: possible mechanisms.
    Pharmacological research, 2006, Volume: 54, Issue:4

    Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Capsaicin; Coloring Agents; Enzyme Inhibitors; Glyburide; Hypoglycemic Agents; KATP Channels; Lamiaceae; Male; Mice; Morphine; Motor Activity; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Oleanolic Acid; Pain; Pain Measurement; Postural Balance; Potassium Channels, Inwardly Rectifying; Ruthenium Red; Yohimbine

2006
Roles of nitric oxide synthase inhibitor on antinociceptive effects of mu-opioid agonist in mice.
    Protein and peptide letters, 2006, Volume: 13, Issue:10

    Topics: Analgesics; Animals; Enzyme Inhibitors; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oligopeptides; Pain; Receptors, Opioid, mu

2006
Extracellular signal-regulated kinase (ERK) and nitric oxide synthase mediate intrathecal morphine-induced nociceptive behavior.
    Neuropharmacology, 2007, Volume: 52, Issue:5

    Topics: Amidines; Analgesics, Opioid; Animals; Behavior, Animal; Benzylamines; Blotting, Western; Butadienes; Dose-Response Relationship, Drug; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Indazoles; Injections, Spinal; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitriles; Nociceptors; Pain; Signal Transduction

2007
Somatosensory pain does not affect total cerebral blood volume.
    Neuroreport, 2007, May-07, Volume: 18, Issue:7

    Topics: Animals; Brain; Cerebrovascular Circulation; Enzyme Inhibitors; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Rats; Rats, Wistar; Regional Blood Flow; Sciatic Nerve

2007
Role of NO/cGMP/KATP pathway in antinociceptive effect of sildenafil in zymosan writhing response in mice.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2007, Volume: 56, Issue:2

    Topics: Analgesics; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; Pain; Piperazines; Potassium Channels; Purines; Quinoxalines; Signal Transduction; Sildenafil Citrate; Sulfones; Zymosan

2007
Twenty-four-hour variation of L-arginine/nitric oxide/cyclic guanosine monophosphate pathway demonstrated by the mouse visceral pain model.
    Chronobiology international, 2007, Volume: 24, Issue:3

    Topics: Abdominal Pain; Analgesics; Animals; Arginine; Benzoquinones; Circadian Rhythm; Cyclic GMP; Enzyme Inhibitors; Male; Methylene Blue; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitrites; Nitroprusside; Pain; Pain Measurement; Signal Transduction

2007
TENS stimulates constitutive nitric oxide release via opiate signaling in invertebrate neural tissues.
    Medical science monitor : international medical journal of experimental and clinical research, 2007, Volume: 13, Issue:8

    Topics: Animals; Calibration; Ganglia; Models, Biological; Morphine; Mytilus edulis; Naloxone; Nervous System; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Opioid Peptides; Pain; Signal Transduction; Transcutaneous Electric Nerve Stimulation

2007
Antinociceptive effect from Davilla elliptica hydroalcoholic extract.
    Journal of ethnopharmacology, 2007, Sep-05, Volume: 113, Issue:2

    Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Brazil; Cyclooxygenase Inhibitors; Diclofenac; Dilleniaceae; Enzyme Inhibitors; Ethanol; Formaldehyde; Hindlimb; Male; Medicine, Traditional; Mice; NG-Nitroarginine Methyl Ester; Pain; Pain Measurement; Plant Components, Aerial; Plant Extracts; Water

2007
Therapeutic manipulation of peroxynitrite attenuates the development of opiate-induced antinociceptive tolerance in mice.
    The Journal of clinical investigation, 2007, Volume: 117, Issue:11

    Topics: Analgesics, Opioid; Animals; Cytokines; DNA Damage; Drug Tolerance; Enzyme Inhibitors; Free Radical Scavengers; Humans; Male; Metalloporphyrins; Mice; NG-Nitroarginine Methyl Ester; Pain; Pain Threshold; Peroxynitrous Acid; Poly(ADP-ribose) Polymerases; Porphyrins; Rats; Spinal Cord; Superoxide Dismutase; Tyrosine

2007
Role of nitric oxide/cyclic GMP/K(+) channel pathways in the antinociceptive effect caused by 2,3-bis(mesitylseleno)propenol.
    Life sciences, 2007, Dec-14, Volume: 81, Issue:25-26

    Topics: Analgesics; Animals; Behavior, Animal; Cyclic GMP; Dose-Response Relationship, Drug; Formaldehyde; Glutamic Acid; Glyburide; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Organoselenium Compounds; p-Methoxy-N-methylphenethylamine; Pain; Pain Measurement; Potassium Channels; Rats; Rats, Wistar; Serotonin; Signal Transduction

2007
Systemic N-nitro-L-arginine-ester (L-NAME), inhibitor of nitric oxide synthase, relieves chronic allodynia-like symptom in rats with spinal cord lesion.
    Acta physiologica Scandinavica, 1994, Volume: 150, Issue:4

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; Female; Injections, Intraperitoneal; Ischemia; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Palliative Care; Pressure; Rats; Rats, Sprague-Dawley; Spinal Cord

1994
Effect of topical administration of L-arginine on formalin-induced nociception in the mouse: a dual role of peripherally formed NO in pain modulation.
    British journal of pharmacology, 1994, Volume: 112, Issue:2

    Topics: Administration, Topical; Amino Acid Oxidoreductases; Animals; Arginine; Behavior, Animal; Dose-Response Relationship, Drug; Formaldehyde; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Stereoisomerism

1994
Intracellular messengers contributing to persistent nociception and hyperalgesia induced by L-glutamate and substance P in the rat formalin pain model.
    The European journal of neuroscience, 1994, Aug-01, Volume: 6, Issue:8

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Arachidonic Acid; Arginine; Dexamethasone; Formaldehyde; Glutamic Acid; Hyperalgesia; Injections, Spinal; Isoquinolines; Male; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Measurement; Pain Threshold; Piperazines; Protein Kinase C; Rats; Reflex; Substance P

1994
Nitric oxide mediates allodynia induced by intrathecal administration of prostaglandin E2 or prostaglandin F2 alpha in conscious mice.
    Pain, 1995, Volume: 61, Issue:2

    Topics: Analysis of Variance; Animals; Arginine; Dinoprost; Dinoprostone; Dose-Response Relationship, Drug; Injections, Spinal; Male; Methylene Blue; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Receptors, Metabotropic Glutamate; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission

1995
L-NG-nitro arginine p-nitroanilide (L-NAPNA) is anti-nociceptive in the mouse.
    Neuroreport, 1993, Volume: 4, Issue:3

    Topics: Amino Acid Oxidoreductases; Analgesics; Anilides; Animals; Aorta, Thoracic; Arginine; Blood Pressure; Brain; Formaldehyde; In Vitro Techniques; Male; Mice; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; omega-N-Methylarginine; Pain; Rabbits; Rats; Rats, Sprague-Dawley

1993
Nitric oxide mediates neuropathic pain behavior in peripherally denervated rats.
    Neuroscience letters, 1995, Mar-16, Volume: 188, Issue:1

    Topics: Animals; Arginine; Behavior, Animal; Cyclic AMP; Denervation; Disease Models, Animal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Peripheral Nerves; Phantom Limb; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord; Stereoisomerism; Synaptic Transmission; Time Factors

1995
Analysis of the role of endothelin-A and endothelin-B receptors on nociceptive information transmission in the spinal cord with FR139317, an endothelin-A receptor antagonist, and sarafotoxin S6c, an endothelin-B receptor agonist.
    The Journal of pharmacology and experimental therapeutics, 1994, Volume: 271, Issue:1

    Topics: Animals; Arginine; Azepines; Behavior, Animal; Endothelin Receptor Antagonists; Endothelins; Formaldehyde; Indoles; Male; NG-Nitroarginine Methyl Ester; Pain; Rats; Rats, Sprague-Dawley; Receptors, Endothelin; Receptors, N-Methyl-D-Aspartate; Spinal Cord; Viper Venoms

1994
Spinal nitric oxide synthesis inhibition blocks NMDA-induced thermal hyperalgesia and produces antinociception in the formalin test in rats.
    Pain, 1993, Volume: 54, Issue:3

    Topics: Analgesics; Animals; Arginine; Behavior, Animal; Formaldehyde; Hot Temperature; Injections, Spinal; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; omega-N-Methylarginine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Spinal Cord

1993
Application of nitric oxide synthase inhibitor, N omega-nitro-L-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats.
    Neuroscience letters, 1996, May-31, Volume: 210, Issue:2

    Topics: Animals; Enzyme Inhibitors; Free Radicals; Hot Temperature; Hyperalgesia; Ligation; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve

1996
L-NAME, an inhibitor of nitric oxide synthase, blocks the established allodynia induced by intrathecal administration of prostaglandin E2.
    Neuroscience letters, 1995, Dec-15, Volume: 201, Issue:3

    Topics: Animals; Arginine; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Spinal; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Pain; Spinal Cord

1995
Induction of spinal cord neuronal nitric oxide synthase (NOS) after formalin injection in the rat hind paw.
    Neuroscience letters, 1996, Jun-07, Volume: 210, Issue:3

    Topics: Animals; Enzyme Induction; Foot; Formaldehyde; Injections; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Up-Regulation

1996
Antinociceptive synergistic interaction between morphine and n omega-nitro 1-arginine methyl ester on thermal nociceptive tests in the rats.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 1996, Volume: 43, Issue:9

    Topics: Analgesics, Opioid; Animals; Drug Synergism; Enzyme Inhibitors; Male; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Rats; Rats, Wistar

1996
Treatment of a chronic allodynia-like response in spinally injured rats: effects of systemically administered nitric oxide synthase inhibitors.
    Pain, 1996, Volume: 66, Issue:2-3

    Topics: Adrenergic Agonists; Analgesics; Animals; Arousal; Blood Pressure; Chronic Disease; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epinephrine; Female; Indazoles; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Physical Stimulation; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Cord Injuries

1996
Characterization of nociceptin hyperalgesia and allodynia in conscious mice.
    British journal of pharmacology, 1997, Volume: 121, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptin; Nociceptin Receptor; Opioid Peptides; Pain; Receptors, GABA; Receptors, Glycine; Receptors, Opioid

1997
Nitric oxide is not involved in vascular nociception of noxious physical stimuli in humans.
    Neuroscience letters, 1997, May-16, Volume: 227, Issue:2

    Topics: Adult; Blood Vessels; Humans; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Physical Stimulation

1997
Inhibition of nitric oxide synthase enhances antinociception mediated by mu, delta and kappa opioid receptors in acute and prolonged pain in the rat spinal cord.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 282, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Enzyme Inhibitors; Formaldehyde; Injections, Spinal; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Spinal Cord

1997
Involvement of nitric oxide and serotonin in modulation of antinociception and pressor responses evoked by stimulation in the dorsolateral region of the periaqueductal gray matter in the rat.
    Neuroscience, 1997, Volume: 80, Issue:3

    Topics: Animals; Blood Pressure; Brain Mapping; Electric Stimulation; Hot Temperature; Interneurons; Male; Microinjections; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Periaqueductal Gray; Rats; Rats, Wistar; Reaction Time; Serotonin; Stereoisomerism

1997
Rapid development of nitric oxide-induced hyperalgesia depends on an alternate to the cGMP-mediated pathway in the rat neuropathic pain model.
    Brain research, 1998, May-11, Volume: 792, Issue:2

    Topics: Animals; Antidotes; Cyclic GMP; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Hemoglobins; Hot Temperature; Hyperalgesia; Ligation; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroso Compounds; Pain; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Spinal Cord

1998
Circadian-rhythm-dependent effects of L-NG-nitroarginine methyl ester (L-NAME) on morphine-induced analgesia.
    Chronobiology international, 1998, Volume: 15, Issue:3

    Topics: Analgesia; Animals; Circadian Rhythm; Drug Interactions; Enzyme Inhibitors; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Pain Measurement

1998
The role of nitric oxide in neuropathic pain and neurodegeneration.
    Acta anaesthesiologica Scandinavica. Supplementum, 1998, Volume: 113

    Topics: Analgesics; Animals; Disease Models, Animal; Enzyme Inhibitors; Nerve Degeneration; Nervous System Diseases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Receptors, N-Methyl-D-Aspartate

1998
Cyclic GMP pathway is critical for inducing long-term sensitization of nociceptive sensory neurons.
    Nature neuroscience, 1999, Volume: 2, Issue:1

    Topics: Animals; Aplysia; Cyclic AMP Response Element-Binding Protein; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; Ganglia, Invertebrate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Pain; Physical Stimulation; Protein Kinases; Time Factors; Transcription, Genetic

1999
Acetazolamide and amiloride inhibit pentobarbital-induced facilitation of nocifensive reflexes.
    Anesthesiology, 1999, Volume: 90, Issue:4

    Topics: Acetazolamide; Amiloride; Animals; GABA Modulators; Male; NG-Nitroarginine Methyl Ester; Pain; Pentobarbital; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, GABA-A; Reflex

1999
Antinociception after both peripheral and intrathecal injection of oxotremorine is modulated by spinal nitric oxide.
    European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 1999, Volume: 9, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Enzyme Inhibitors; Injections, Intraperitoneal; Injections, Spinal; Male; Molsidomine; Muscarinic Agonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nociceptors; Oxotremorine; Pain; Pain Measurement; Rats; Rats, Wistar; Spinal Cord

1999
Antinociceptive properties and nitric oxide synthase inhibitory action of new ruthenium complexes.
    European journal of pharmacology, 1999, Mar-26, Volume: 369, Issue:3

    Topics: Analgesics; Animals; Blood Pressure; Drug Interactions; Enzyme Inhibitors; Isoenzymes; Male; Mice; Motor Activity; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitroarginine; Pain; Rabbits; Rats; Rats, Wistar; Ruthenium Compounds; Structure-Activity Relationship

1999
Antinociceptive mechanism of Gosha-jinki-gan in streptozotocin-induced diabetic animals: role of nitric oxide in the periphery.
    Japanese journal of pharmacology, 1999, Volume: 79, Issue:3

    Topics: Analgesics; Animals; Arginine; Diabetes Mellitus, Experimental; Drugs, Chinese Herbal; Enzyme Inhibitors; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nociceptors; Pain; Pain Threshold; Rats; Rats, Sprague-Dawley; Tail

1999
L-NAME, a nitric oxide synthase inhibitor, modulates cholinergic antinociception.
    Methods and findings in experimental and clinical pharmacology, 1999, Volume: 21, Issue:3

    Topics: Acetic Acid; Analgesics; Animals; Buspirone; Cholinergic Agents; Drug Synergism; Enzyme Inhibitors; Female; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain; Receptors, Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Sumatriptan

1999
Hyperactivity caused by a nitric oxide synthase inhibitor is countered by ultra-wideband pulses.
    Bioelectromagnetics, 1999, Volume: 20, Issue:7

    Topics: Analysis of Variance; Animals; Electromagnetic Fields; Enzyme Inhibitors; Hyperkinesis; Injections, Intraperitoneal; Locomotion; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nociceptors; Pain; Pain Threshold; Reaction Time; Sodium Chloride; Time Factors

1999
Evidence for the participation of the nitric oxide-cyclic GMP pathway in the antinociceptive action of meloxicam in the formalin test.
    European journal of pharmacology, 2000, Apr-21, Volume: 395, Issue:1

    Topics: Analgesics, Non-Narcotic; Animals; Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Formaldehyde; Guanylate Cyclase; Meloxicam; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Quinoxalines; Rats; Rats, Wistar; Thiazines; Thiazoles

2000
The role of nitric oxide and prostaglandin E2 on the hyperalgesia induced by excitatory amino acids in rats.
    The Journal of pharmacy and pharmacology, 2000, Volume: 52, Issue:4

    Topics: Animals; Dinoprostone; Dizocilpine Maleate; Excitatory Amino Acids; Formaldehyde; Hyperalgesia; Indomethacin; Male; N-Methylaspartate; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Time Factors

2000
Role of guanylyl cyclase activation via thiamine in suppressing chemically-induced writhing in mouse.
    Arzneimittel-Forschung, 2000, Volume: 50, Issue:6

    Topics: Animals; Arginine; Benzoquinones; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Male; Mice; Morphine; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Pain; Pain Measurement; Thiamine

2000
Opposing interplay between Neuropeptide FF and nitric oxide in antinociception and hypothermia.
    Peptides, 2000, Volume: 21, Issue:8

    Topics: Analgesics, Opioid; Animals; Area Under Curve; Arginine; Body Temperature; Dose-Response Relationship, Drug; Enzyme Inhibitors; Free Radical Scavengers; Hypothermia; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Pain; Temperature

2000
How central is nitric oxide (NO) to the activation of c-fos in spinal neurones following noxious peripheral stimulation in the rat?
    Brain research, 2001, Jan-05, Volume: 888, Issue:1

    Topics: Animals; Enzyme Inhibitors; Female; Male; Mustard Plant; Neurons; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nociceptors; Noxae; Pain; Peripheral Nerves; Plant Extracts; Plant Oils; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Spinal Cord

2001
Antinociceptive effect of spinally injected L-NAME on the acute nociceptive response induced by low concentrations of formalin.
    Neurochemistry international, 2001, Volume: 38, Issue:5

    Topics: Analgesics; Animals; Enzyme Inhibitors; Formaldehyde; Injections, Spinal; Male; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pain

2001
Potentiation by nitric oxide synthase inhibitor and calcium channel blocker of aspartame-induced antinociception in the mouse formalin test.
    Fundamental & clinical pharmacology, 2001, Volume: 15, Issue:2

    Topics: Analgesics; Animals; Aspartame; Calcium Channel Blockers; Drug Synergism; Enzyme Inhibitors; Male; Mice; Mice, Inbred Strains; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain; Pain Measurement; Receptors, N-Methyl-D-Aspartate; Verapamil

2001
Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway.
    Brain research, 2001, Aug-03, Volume: 909, Issue:1-2

    Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Acetic Acid; Analgesia; Animals; Arginine; Carrageenan; Central Nervous System; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Female; Hyperalgesia; Male; Methylene Blue; Mice; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Nociceptors; Pain; Pain Measurement; Pain Threshold; Peripheral Nervous System; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Purines; Signal Transduction; Sildenafil Citrate; Sulfones

2001
Participation of the nitric oxide-cyclic GMP-ATP-sensitive K(+) channel pathway in the antinociceptive action of ketorolac.
    European journal of pharmacology, 2001, Aug-24, Volume: 426, Issue:1-2

    Topics: Adenosine Triphosphate; Analgesics; Animals; Behavior, Animal; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glyburide; Guanylate Cyclase; Ketorolac; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Oxadiazoles; Pain; Pain Measurement; Penicillamine; Potassium Channels; Quinoxalines; Rats; Rats, Wistar; Signal Transduction

2001
Dual effect of nitric oxide in articular inflammatory pain in zymosan-induced arthritis in rats.
    British journal of pharmacology, 2002, Volume: 136, Issue:4

    Topics: Amidines; Animals; Arthritis, Experimental; Benzylamines; Cartilage, Articular; Dinoprost; Edema; Enzyme Inhibitors; Guanidines; Injections, Intra-Articular; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pain; Pain Measurement; Rats; Rats, Wistar; Zymosan

2002
Increase of nitric oxide production by L-arginine potentiates i.c.v. administered beta-endorphin-induced antinociception in the mouse.
    European journal of pharmacology, 1992, Mar-03, Volume: 212, Issue:2-3

    Topics: Amino Acid Oxidoreductases; Animals; Arginine; beta-Endorphin; Drug Synergism; Injections, Intraventricular; Male; Mice; Mice, Inbred ICR; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pain

1992
Synergistic anti-nociceptive effect of L-NG-nitro arginine methyl ester (L-NAME) and flurbiprofen in the mouse.
    British journal of pharmacology, 1992, Volume: 106, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arginine; Behavior, Animal; Blood Pressure; Drug Synergism; Flurbiprofen; Formaldehyde; Indomethacin; Male; Mice; Motor Activity; NG-Nitroarginine Methyl Ester; Pain

1992
Nitric oxide mediates the thermal hyperalgesia produced in a model of neuropathic pain in the rat.
    Neuroscience, 1992, Volume: 50, Issue:1

    Topics: Analysis of Variance; Animals; Arginine; Hot Temperature; Hyperalgesia; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate

1992
L-NG-nitro arginine methyl ester exhibits antinociceptive activity in the mouse.
    British journal of pharmacology, 1991, Volume: 102, Issue:1

    Topics: Administration, Oral; Analgesics; Animals; Arginine; Behavior, Animal; Blood Pressure; Brain Chemistry; Edema; Formaldehyde; Injections, Intraventricular; Male; Mice; Mice, Inbred Strains; Motor Activity; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pain

1991
Discovery of N-(3-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-1H-indol-6-yl) thiophene-2-carboximidamide as a selective inhibitor of human neuronal nitric oxide synthase (nNOS) for the treatment of pain.
    Journal of medicinal chemistry, 2011, Oct-27, Volume: 54, Issue:20

    Topics: Analgesics; Coronary Vessels; Cytochrome P-450 Enzyme Inhibitors; Hot Temperature; Humans; Hyperalgesia; Indoles; Ligation; Neuralgia; Nitric Oxide Synthase Type I; Pain; Pyridines; Spinal Nerves; Stereoisomerism; Structure-Activity Relationship; Thiophenes; Vascular Resistance; Vasoconstriction

2011