nevirapine has been researched along with Sensitivity and Specificity in 56 studies
Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.
nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The method was sensitive, specific, precise, accurate and suitable for bioequivalence and pharmacokinetic studies." | 2.75 | Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. ( Damaramadugu, R; Inamadugu, JK; Mullangi, R; Ponneri, V, 2010) |
| "Body weight was measured in kilograms with light clothes on." | 2.72 | The value of serum albumin in pretreatment assessment and monitoring of therapy in HIV/AIDS patients. ( Olatunji, PO; Olawumi, HO, 2006) |
| " The method was successfully applied to quantify them in a rat pharmacokinetic study in whole blood, plasma and DBS cards after a single oral co-administration at the dose of 10, 2 and 13 mg/kg for lamivudine, stavudine and nevirapine, respectively, to male Wistar rats." | 1.38 | Exploring dried blood spot sampling technique for simultaneous quantification of antiretrovirals: lamivudine, stavudine and nevirapine in a rodent pharmacokinetic study. ( Aleti, R; Bhyrapuneni, G; Kalaikadhiban, I; Kandikere, V; Komarneni, P; Muddana, N; Nirogi, R; Padala, N, 2012) |
| " The developed assay method was successfully applied to a pharmacokinetic study in humans." | 1.38 | Simultaneous determination of atorvastatin and niacin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. ( Gajula, R; Inamadugu, JK; Mullangi, R; Pilli, NR; Ponneri, V; Ravi, VB, 2012) |
| " The developed assay method was successfully applied to a pharmacokinetic study in human male volunteers." | 1.37 | Simultaneous determination of atorvastatin, amlodipine, ramipril and benazepril in human plasma by LC-MS/MS and its application to a human pharmacokinetic study. ( Inamadugu, JK; Karra, VK; Mullangi, R; Pilli, NR; Rao, JV; Vaidya, JR, 2011) |
| "A highly sensitive and specific LC-MS/MS assay was developed and validated to quantify nevirapine (NVP) and its five metabolites [2-, 3-, 8-, 12-hydroxyl NVP (OHNVP) and 4-carboxyl NVP (CANVP)] simultaneously in baboon serum and the assay was used to characterize their pharmacokinetic studies of an oral-dose escalation study in baboon." | 1.36 | A sensitive and specific liquid chromatography/tandem mass spectrometry method for quantification of nevirapine and its five metabolites and their pharmacokinetics in baboons. ( Chan, KK; Fan-Havard, P; Ling, Y; Liu, Z; Ren, C; Schlabritz-Loutsevitch, N, 2010) |
| " TDM is useful to determine the best dosage regimen adapted to each patient." | 1.35 | Determination of abacavir, amprenavir, didanosine, efavirenz, nevirapine, and stavudine concentration in human plasma by MALDI-TOF/TOF. ( Alonzi, T; Ascenzi, P; Mancone, C; Narciso, P; Notari, S; Tripodi, M, 2008) |
| " The method has been successfully used to analyze commercial solid dosage form to assess the chromatographic performance of SFC system." | 1.33 | Effect of system variables involved in packed column SFC of nevirapine as model analyte using response surface methodology: application to retention thermodynamics, solute transfer kinetic study and binary diffusion coefficient determination. ( Agrawal, H; Kaul, N; Mahadik, KR; Paradkar, AR, 2005) |
| "Nevirapine is an antiretroviral agent belonging to the class of non-nucleoside reverse transcriptase inhibitors." | 1.31 | Simple and rapid determination of nevirapine in human serum by reversed-phase high-performance liquid chromatography. ( Gomez, MR; Lopez, RM; Monterde, J; Pou, L; Ruiz, I, 2001) |
| "Nevirapine is a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV-1-infected patients." | 1.30 | Rapid determination of nevirapine in human plasma by ion-pair reversed-phase high-performance liquid chromatography with ultraviolet detection. ( Beijnen, JH; Hoetelmans, RM; Meenhorst, PL; Mulder, JW; van Heeswijk, RP, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (5.36) | 18.2507 |
| 2000's | 35 (62.50) | 29.6817 |
| 2010's | 18 (32.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aguiar, RS | 1 |
| Costa, LJ | 1 |
| Pereira, HS | 1 |
| Brindeiro, RM | 1 |
| Tanuri, A | 2 |
| Duthaler, U | 1 |
| Berger, B | 1 |
| Erb, S | 1 |
| Battegay, M | 1 |
| Letang, E | 1 |
| Gaugler, S | 1 |
| Krähenbühl, S | 1 |
| Haschke, M | 1 |
| Kumar, VR | 1 |
| Reddy, BP | 1 |
| Kumar, BR | 1 |
| Sreekanth, K | 1 |
| Babu, KN | 1 |
| Adireddy, V | 1 |
| Pilli, NR | 3 |
| Derangula, VR | 1 |
| Satla, SR | 1 |
| Ganguri, CV | 1 |
| Ponneri, V | 3 |
| Valluru, RK | 1 |
| B, PB | 1 |
| S, KS | 1 |
| V, PK | 1 |
| Kilaru, NB | 1 |
| Frezza, C | 1 |
| Balestrieri, E | 1 |
| Marino-Merlo, F | 1 |
| Mastino, A | 1 |
| Macchi, B | 1 |
| Saegusa, T | 1 |
| Di, C | 1 |
| Chen, YQ | 1 |
| Lamorde, M | 1 |
| Fillekes, Q | 1 |
| Sigaloff, K | 1 |
| Kityo, C | 1 |
| Buzibye, A | 1 |
| Kayiwa, J | 1 |
| Merry, C | 1 |
| Nakatudde-Katumba, L | 1 |
| Burger, D | 1 |
| de Wit, TF | 1 |
| Mutsvangwa, J | 1 |
| Beck, IA | 1 |
| Gwanzura, L | 1 |
| Manhanzva, MT | 1 |
| Stranix-Chibanda, L | 1 |
| Chipato, T | 1 |
| Frenkel, LM | 2 |
| L Machado, S | 1 |
| Gonçalves, GS | 1 |
| Dudley, D | 1 |
| O'Connor, D | 1 |
| Keiko Toma, H | 1 |
| Fernandes, JC | 1 |
| Chen, J | 1 |
| Mannargudi, BM | 1 |
| Xu, L | 1 |
| Uetrecht, J | 1 |
| L'homme, RF | 1 |
| Muro, EP | 1 |
| Droste, JA | 1 |
| Wolters, LR | 1 |
| van Ewijk-Beneken Kolmer, NW | 1 |
| Schimana, W | 1 |
| Burger, DM | 1 |
| Elens, L | 1 |
| Veriter, S | 1 |
| Di Fazio, V | 1 |
| Vanbinst, R | 1 |
| Boesmans, D | 1 |
| Wallemacq, P | 1 |
| Haufroid, V | 1 |
| Church, JD | 3 |
| Huang, W | 1 |
| Parkin, N | 2 |
| Marlowe, N | 2 |
| Guay, LA | 2 |
| Omer, SB | 1 |
| Musoke, P | 2 |
| Jackson, JB | 3 |
| Eshleman, SH | 3 |
| Ren, C | 2 |
| Fan-Havard, P | 2 |
| Schlabritz-Loutsevitch, N | 1 |
| Ling, Y | 1 |
| Chan, KK | 2 |
| Liu, Z | 2 |
| Wagner, TA | 1 |
| Kress, CM | 1 |
| Beck, I | 1 |
| Techapornroong, M | 1 |
| Wittayapraparat, P | 1 |
| Tansuphasawasdikul, S | 1 |
| Jourdain, G | 1 |
| Ngo-Giang-Huong, N | 1 |
| Lallemant, M | 1 |
| Rowley, CF | 1 |
| Boutwell, CL | 1 |
| Lee, EJ | 1 |
| MacLeod, IJ | 1 |
| Ribaudo, HJ | 1 |
| Essex, M | 1 |
| Lockman, S | 1 |
| Inamadugu, JK | 3 |
| Mullangi, R | 3 |
| Karra, VK | 1 |
| Vaidya, JR | 1 |
| Rao, JV | 1 |
| Damaramadugu, R | 1 |
| Shewiyo, DH | 1 |
| Kaale, E | 1 |
| Ugullum, C | 1 |
| Sigonda, MN | 1 |
| Risha, PG | 1 |
| Dejaegher, B | 1 |
| Smeyers-Verbeke, J | 1 |
| Vander Heyden, Y | 1 |
| Huang, Y | 1 |
| Yang, Q | 1 |
| Yoon, K | 1 |
| Lei, Y | 1 |
| Shi, R | 1 |
| Gee, W | 1 |
| Lin, ET | 1 |
| Greenblatt, RM | 1 |
| Gandhi, M | 1 |
| Nirogi, R | 1 |
| Kandikere, V | 1 |
| Komarneni, P | 1 |
| Aleti, R | 1 |
| Padala, N | 1 |
| Kalaikadhiban, I | 1 |
| Bhyrapuneni, G | 1 |
| Muddana, N | 1 |
| Ravi, VB | 1 |
| Gajula, R | 1 |
| Marchei, E | 1 |
| Valvo, L | 1 |
| Pacifici, R | 1 |
| Pellegrini, M | 1 |
| Tossini, G | 1 |
| Zuccaro, P | 1 |
| Chi, J | 1 |
| Jayewardene, AL | 1 |
| Stone, JA | 1 |
| Aweeka, FT | 1 |
| Rezk, NL | 4 |
| Tidwell, RR | 2 |
| Kashuba, AD | 4 |
| Xuei, X | 1 |
| David, CA | 1 |
| Middleton, TR | 1 |
| Lim, B | 1 |
| Pithawalla, R | 1 |
| Chen, CM | 1 |
| Tripathi, RL | 1 |
| Burns, DJ | 1 |
| Warrior, U | 1 |
| Lambert, JS | 1 |
| Harris, DR | 1 |
| Stiehm, ER | 1 |
| Moye, J | 1 |
| Fowler, MG | 2 |
| Meyer, WA | 1 |
| Bethel, J | 1 |
| Mofenson, LM | 1 |
| Dubuisson, JG | 1 |
| King, JR | 1 |
| Stringer, JS | 1 |
| Turner, ML | 1 |
| Bennetto, C | 1 |
| Acosta, EP | 1 |
| Goulder, PJ | 1 |
| Blanckenberg, N | 1 |
| Dong, K | 1 |
| Silverthorn, CF | 1 |
| Parsons, TL | 1 |
| Kaul, N | 1 |
| Agrawal, H | 1 |
| Paradkar, AR | 1 |
| Mahadik, KR | 1 |
| Wu, L | 1 |
| Huang, MH | 1 |
| Zhao, JL | 1 |
| Yang, MS | 1 |
| Ramachandran, G | 1 |
| Hemanthkumar, AK | 1 |
| Kumaraswami, V | 1 |
| Swaminathan, S | 1 |
| Olawumi, HO | 1 |
| Olatunji, PO | 1 |
| Jones, D | 1 |
| Flys, T | 1 |
| Hoover, D | 1 |
| Chen, S | 1 |
| Shi, C | 1 |
| Eshleman, JR | 2 |
| Kumwenda, N | 2 |
| Taha, TE | 2 |
| Choi, SO | 1 |
| Lalonde, MS | 1 |
| Troyer, RM | 1 |
| Syed, AR | 1 |
| Bulime, S | 1 |
| Demers, K | 1 |
| Bajunirwe, F | 1 |
| Arts, EJ | 1 |
| Rowland, LS | 1 |
| MacGregor, TR | 1 |
| Campbell, SJ | 1 |
| Jenkins, R | 1 |
| Pearsall, AB | 1 |
| Morris, JP | 1 |
| Xie, Z | 1 |
| Abdel-Megeed, MF | 1 |
| Saeng-Aroon, S | 1 |
| Yoshida, LM | 1 |
| Ariyoshi, K | 1 |
| Taguchi, M | 1 |
| Pathipvanich, P | 1 |
| Rojanawiwat, A | 1 |
| Matsuda, M | 1 |
| Kannagi, M | 1 |
| Sawanpanyalert, P | 1 |
| Sugiura, W | 1 |
| Auwanit, W | 1 |
| Notari, S | 1 |
| Mancone, C | 1 |
| Alonzi, T | 1 |
| Tripodi, M | 1 |
| Narciso, P | 1 |
| Ascenzi, P | 1 |
| Towler, WI | 1 |
| Hoover, DR | 1 |
| Hudelson, SE | 1 |
| Zhang, H | 1 |
| Vrang, L | 1 |
| Bäckbro, K | 1 |
| Unge, T | 1 |
| Noréen, R | 1 |
| Oberg, B | 1 |
| van Heeswijk, RP | 1 |
| Hoetelmans, RM | 1 |
| Meenhorst, PL | 1 |
| Mulder, JW | 1 |
| Beijnen, JH | 1 |
| Marseille, E | 1 |
| Kahn, JG | 1 |
| Mmiro, F | 1 |
| Guay, L | 1 |
| Li, QC | 1 |
| Tougas, T | 1 |
| Cohen, K | 1 |
| Lee, R | 1 |
| Meagan, P | 1 |
| Corson, M | 1 |
| Muchnick, T | 1 |
| Resch, W | 1 |
| Stuelke, EL | 1 |
| Watkins, T | 1 |
| Swanstrom, R | 1 |
| Lopez, RM | 1 |
| Pou, L | 1 |
| Gomez, MR | 1 |
| Ruiz, I | 1 |
| Monterde, J | 1 |
| Villani, P | 1 |
| Feroggio, M | 1 |
| Gianelli, L | 1 |
| Bartoli, A | 1 |
| Montagna, M | 1 |
| Maserati, R | 1 |
| Regazzi, MB | 1 |
| Dailly, E | 1 |
| Thomas, L | 1 |
| Kergueris, MF | 1 |
| Jolliet, P | 1 |
| Bourin, M | 1 |
| Langmann, P | 1 |
| Schirmer, D | 1 |
| Väth, T | 1 |
| Desch, S | 1 |
| Zilly, M | 1 |
| Klinker, H | 1 |
| Laurito, TL | 1 |
| Santagada, V | 1 |
| Caliendo, G | 1 |
| Oliveira, CH | 1 |
| Barrientos-Astigarraga, RE | 1 |
| De Nucci, G | 1 |
| Marzolini, C | 1 |
| Béguin, A | 1 |
| Telenti, A | 1 |
| Schreyer, A | 1 |
| Buclin, T | 1 |
| Biollaz, J | 1 |
| Decosterd, LA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Observational Cohort of HIV Infected Adults and Children in the PHPT Network Hospitals in Thailand[NCT00433030] | 2,816 participants (Actual) | Observational | 2007-01-31 | Completed | |||
| URBAN ARCH (3/5) Uganda Cohort TB Preventive Therapy for HIV-infected Alcohol Users in Uganda: an Evaluation of Safety Tolerability and Adherence[NCT03302299] | Phase 4 | 302 participants (Actual) | Interventional | 2017-04-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Safety will be assessed by the occurrence of a Grade 3/4 hepatotoxicity at any time during the assigned treatment period. (NCT03302299)
Timeframe: Hepatotoxicity occurring during the six month course (180 pills) of isoniazid (INH), which may be taken over a maximum of 9 months.
| Intervention | percent (Number) |
|---|---|
| INH and Vitamin B6 | 8.3 |
Lack of tolerability will be defined as any isoniazid (INH) treatment discontinuation prior to completion of the prescribed course (6 months of INH taken over a maximum period of 9 months) due to side effects or alanine transaminase (ALT)/aspartate transaminase (AST) elevations. (NCT03302299)
Timeframe: Six month course (180 pills) of isoniazid (INH), which may be taken over a maximum of 9 months.
| Intervention | Participants (Count of Participants) |
|---|---|
| INH and Vitamin B6 | 32 |
Alanine transaminase (ALT) or aspartate transaminase (AST) elevations (>2x the upper limit of normal) at study screening (NCT03302299)
Timeframe: Study screening visit
| Intervention | Participants (Count of Participants) |
|---|---|
| Study Screening | 80 |
Latent tuberculosis assessed at screening via tuberculin skin testing (TST). A TST induration >=5mm was considered positive for latent tuberculosis. (NCT03302299)
Timeframe: Study screening visit
| Intervention | Participants (Count of Participants) |
|---|---|
| Study Screening | 308 |
INH concentration in hair (pmol/mg) will be measured at 3- and 6- months during INH therapy. (NCT03302299)
Timeframe: Measured at 3- and 6- months after INH initiation
| Intervention | pmol/mg (Median) | |
|---|---|---|
| at 3 months | at 6 months | |
| INH and Vitamin B6 | 36.0 | 37.8 |
Suboptimal INH adherence was defined as <90% of days with at least 1 electronic medication management (EMM) pill cap opening in the previous 90 days, at 3- and 6-months. (NCT03302299)
Timeframe: Adherence will be measured over the 6 months on INH or until INH discontinuation (whichever is shorter)
| Intervention | percentage of participants (Number) | |
|---|---|---|
| at 3 months | at 6 months | |
| INH and Vitamin B6 | 31.3 | 43.9 |
"Participants were asked In the past 30 days, how many days in total have you not taken your pill? and were presented with a visual analog scale (VAS) to indicate the percentage of INH taken in the past 30 days. We converted the VAS percentage into number of days out of 30 to match the first question. Our final self-report measure was the minimum number of the 2 self-reported measurements." (NCT03302299)
Timeframe: Self-reported INH medication adherence via VAS will be measured 3- and 6- months after starting INH
| Intervention | days (Median) | |
|---|---|---|
| at 3 months | at 6 months | |
| INH and Vitamin B6 | 30 | 30 |
The Self Rating Single Item (SRSI) adherence scale asks participants to rate their ability to take their medications as prescribed over the past 30 days. Participants reporting INH use in the prior 30 days at the 3- or 6-month interview are included here, and reported their INH adherence in the prior 30 days as excellent, very good, good, fair, poor, or very poor. (NCT03302299)
Timeframe: Self-reported INH medication adherence via SRSI will be measured 3- and 6- months after starting INH
| Intervention | Participants (Count of Participants) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| At 3 months72558043 | At 6 months72558043 | |||||||||||
| Excellent | Very good | Good | Fair | Poor | Very poor | |||||||
| INH and Vitamin B6 | 160 | |||||||||||
| INH and Vitamin B6 | 79 | |||||||||||
| INH and Vitamin B6 | 38 | |||||||||||
| INH and Vitamin B6 | 2 | |||||||||||
| INH and Vitamin B6 | 124 | |||||||||||
| INH and Vitamin B6 | 90 | |||||||||||
| INH and Vitamin B6 | 41 | |||||||||||
| INH and Vitamin B6 | 4 | |||||||||||
| INH and Vitamin B6 | 0 | |||||||||||
| INH and Vitamin B6 | 1 | |||||||||||
4 trials available for nevirapine and Sensitivity and Specificity
| Article | Year |
|---|---|
Hypothesis testing for an extended cox model with time-varying coefficients.
Topics: Algorithms; Biometry; Computer Simulation; Data Interpretation, Statistical; Female; HIV Infections; | 2014 |
Simultaneous determination of niacin and its metabolites--nicotinamide, nicotinuric acid and N-methyl-2-pyridone-5-carboxamide--in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.
Topics: Chromatography, Liquid; Drug Stability; Humans; Linear Models; Male; Nevirapine; Niacin; Niacinamide | 2010 |
Performance characteristics of HIV-1 culture and HIV-1 DNA and RNA amplification assays for early diagnosis of perinatal HIV-1 infection.
Topics: Acquired Immunodeficiency Syndrome; Anti-HIV Agents; DNA, Viral; HIV Infections; HIV-1; Humans; Infa | 2003 |
The value of serum albumin in pretreatment assessment and monitoring of therapy in HIV/AIDS patients.
Topics: Adult; Anti-HIV Agents; Body Weight; CD4 Lymphocyte Count; Female; HIV Infections; Humans; Lamivudin | 2006 |
52 other studies available for nevirapine and Sensitivity and Specificity
| Article | Year |
|---|---|
Development of a new methodology for screening of human immunodeficiency virus type 1 microbicides based on real-time PCR quantification.
Topics: Alkynes; Benzoxazines; Biological Assay; Cell-Free System; Cyclopropanes; Female; HIV-1; Humans; Nev | 2007 |
Automated high throughput analysis of antiretroviral drugs in dried blood spots.
Topics: Alkynes; Anti-Retroviral Agents; Benzoxazines; Chromatography, High Pressure Liquid; Cyclopropanes; | 2017 |
High throughput LC-MS/MS method for simultaneous determination of zidovudine, lamivudine and nevirapine in human plasma.
Topics: Anti-HIV Agents; Chromatography, Liquid; Humans; Lamivudine; Male; Nevirapine; Sensitivity and Speci | 2013 |
Liquid chromatography-tandem mass spectrometric assay for aliskiren, a novel renin inhibitor in micro-volumes of human plasma: a pharmacokinetic application in healthy South Indian male subjects.
Topics: Amides; Chromatography, Liquid; Drug Stability; Fumarates; Humans; India; Liquid-Liquid Extraction; | 2013 |
High throughput LC-MS/MS method for simultaneous determination of tenofovir, lamivudine and nevirapine in human plasma.
Topics: Adenine; Chromatography, High Pressure Liquid; Humans; Lamivudine; Linear Models; Male; Nevirapine; | 2013 |
A novel, cell-free PCR-based assay for evaluating the inhibitory activity of antiretroviral compounds against HIV reverse transcriptase.
Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Cyclopropanes; DNA, Complementary; Drug Evaluation, Preclini | 2014 |
Therapeutic drug monitoring of nevirapine in saliva in Uganda using high performance liquid chromatography and a low cost thin-layer chromatography technique.
Topics: Adult; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Cohort Studies; Cross-Secti | 2014 |
Optimization of the oligonucleotide ligation assay for the detection of nevirapine resistance mutations in Zimbabwean Human Immunodeficiency Virus type-1 subtype C.
Topics: Anti-HIV Agents; Drug Resistance, Viral; Genotype; Genotyping Techniques; HIV Infections; HIV-1; Hum | 2014 |
Development of a Qualitative Quantitative Polymerase Chain Reaction Test to Identify Patients Failing First-Line Therapy to Non-Nucleotide Reverse Transcriptase Inhibitor.
Topics: Alkynes; Benzoxazines; Costs and Cost Analysis; Cyclopropanes; Drug Monitoring; Drug Resistance, Vir | 2017 |
Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash.
Topics: Animals; Chromatography, Liquid; Disease Models, Animal; Dose-Response Relationship, Drug; Exanthema | 2008 |
Therapeutic drug monitoring of nevirapine in resource-limited settings.
Topics: Adolescent; Adult; Africa; Aged; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; D | 2008 |
Quantification of 8 HIV-protease inhibitors and 2 nonnucleoside reverse transcriptase inhibitors by ultra-performance liquid chromatography with diode array detection.
Topics: Alkynes; Atazanavir Sulfate; Benzoxazines; Carbamates; Chromatography, High Pressure Liquid; Cyclopr | 2009 |
Comparison of laboratory methods for analysis of non-nucleoside reverse transcriptase inhibitor resistance in Ugandan infants.
Topics: Age Factors; Drug Resistance, Viral; HIV; HIV Infections; Humans; Infant; Mutation; Nevirapine; Reag | 2009 |
A sensitive and specific liquid chromatography/tandem mass spectrometry method for quantification of nevirapine and its five metabolites and their pharmacokinetics in baboons.
Topics: Animals; Anti-HIV Agents; Chromatography, Liquid; Female; Nevirapine; Papio; Sensitivity and Specifi | 2010 |
Detection of HIV-1 drug resistance in women following administration of a single dose of nevirapine: comparison of plasma RNA to cellular DNA by consensus sequencing and by oligonucleotide ligation assay.
Topics: Adult; Anti-HIV Agents; Chemoprevention; DNA Primers; DNA, Viral; Drug Resistance, Viral; Female; HI | 2010 |
Ultrasensitive detection of minor drug-resistant variants for HIV after nevirapine exposure using allele-specific PCR: clinical significance.
Topics: Botswana; Drug Resistance, Viral; Female; Gene Frequency; Genetic Variation; HIV Infections; HIV-1; | 2010 |
Simultaneous determination of atorvastatin, amlodipine, ramipril and benazepril in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.
Topics: Amlodipine; Anticholesteremic Agents; Antihypertensive Agents; Atorvastatin; Benzazepines; Chromatog | 2011 |
Development and validation of a normal-phase HPTLC method for the simultaneous analysis of lamivudine, stavudine and nevirapine in fixed-dose combination tablets.
Topics: Anti-HIV Agents; Calibration; Chromatography, Thin Layer; Densitometry; Drug Combinations; Humans; L | 2011 |
Microanalysis of the antiretroviral nevirapine in human hair from HIV-infected patients by liquid chromatography-tandem mass spectrometry.
Topics: Anti-HIV Agents; Chromatography, Liquid; Cohort Studies; Hair; HIV Infections; Humans; Nevirapine; R | 2011 |
Exploring dried blood spot sampling technique for simultaneous quantification of antiretrovirals: lamivudine, stavudine and nevirapine in a rodent pharmacokinetic study.
Topics: Animals; Anti-Retroviral Agents; Chromatography, High Pressure Liquid; Dried Blood Spot Testing; Dru | 2012 |
Simultaneous determination of atorvastatin and niacin in human plasma by LC-MS/MS and its application to a human pharmacokinetic study.
Topics: Atorvastatin; Chromatography, High Pressure Liquid; Drug Stability; Heptanoic Acids; Humans; Linear | 2012 |
Simultaneous determination of zidovudine and nevirapine in human plasma by RP-LC.
Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Humans; Nevirapine; Reproducibility of Result | 2002 |
An LC-MS-MS method for the determination of nevirapine, a non-nucleoside reverse transcriptase inhibitor, in human plasma.
Topics: Anti-HIV Agents; Calibration; Chromatography, High Pressure Liquid; Drug Stability; Humans; Mass Spe | 2003 |
Simultaneous determination of six HIV nucleoside analogue reverse transcriptase inhibitors and nevirapine by liquid chromatography with ultraviolet absorbance detection.
Topics: Chromatography, High Pressure Liquid; Humans; Nevirapine; Reverse Transcriptase Inhibitors; Sensitiv | 2003 |
Use of SAM2 biotin capture membrane in microarrayed compound screening (muARCS) format for nucleic acid polymerization assays.
Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Biotin; Biotinylation; Cyclopropanes; DNA; Dose-Response Rel | 2003 |
Detection of nevirapine in plasma using thin-layer chromatography.
Topics: Anti-HIV Agents; Chromatography, Thin Layer; HIV Infections; Humans; Nevirapine; Reproducibility of | 2004 |
Nevirapine plus zidovudine to prevent mother-to-child transmission of HIV.
Topics: Anti-Retroviral Agents; DNA, Viral; Female; HIV; HIV Infections; Humans; Infant, Newborn; Infectious | 2004 |
A validated new method for nevirapine quantitation in human plasma via high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Humans; Nevirapine; Reproducibility of Results; Reverse Transc | 2006 |
Effect of system variables involved in packed column SFC of nevirapine as model analyte using response surface methodology: application to retention thermodynamics, solute transfer kinetic study and binary diffusion coefficient determination.
Topics: Anti-HIV Agents; Biophysical Phenomena; Biophysics; Calibration; Chromatography; Chromatography, Hig | 2005 |
Study of MMLV RT- binding with DNA using surface plasmon resonance biosensor.
Topics: Alkynes; Benzoxazines; Cyclopropanes; DNA; DNA Damage; DNA Primers; DNA, Single-Stranded; Kinetics; | 2005 |
A simple and rapid liquid chromatography method for simultaneous determination of zidovudine and nevirapine in plasma.
Topics: Adult; Chromatography, High Pressure Liquid; Female; Humans; Male; Nevirapine; Reproducibility of Re | 2006 |
Sensitivity of the ViroSeq HIV-1 genotyping system for detection of the K103N resistance mutation in HIV-1 subtypes A, C, and D.
Topics: Anti-HIV Agents; Drug Resistance, Viral; Female; Genotype; HIV-1; Humans; Mutation; Nevirapine; Poin | 2006 |
High-performance liquid chromatography assay for the determination of the HIV-protease inhibitor tipranavir in human plasma in combination with nine other antiretroviral medications.
Topics: Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Carbamates; Chromatography, High Pressur | 2007 |
Sensitive oligonucleotide ligation assay for low-level detection of nevirapine resistance mutations in human immunodeficiency virus type 1 quasispecies.
Topics: Amino Acid Substitution; Anti-HIV Agents; Drug Resistance, Viral; Female; HIV Infections; HIV-1; Hum | 2007 |
Quantitation of five nevirapine oxidative metabolites in human plasma using liquid chromatography-tandem mass spectrometry.
Topics: Calibration; Humans; Nevirapine; Oxidation-Reduction; Quality Control; Reference Standards; Reproduc | 2007 |
A liquid chromatography/atmospheric pressure ionization tandem mass spectrometry quantitation method for nevirapine and its two oxidative metabolites, 2-hydroxynevirapine and nevirapine 4-carboxylic acid, and pharmacokinetics in baboons.
Topics: Animals; Anti-HIV Agents; Atmospheric Pressure; Blood Chemical Analysis; Carboxylic Acids; Chromatog | 2007 |
Development of a highly efficient extraction technique and specific multiplex assay for measuring antiretroviral drug concentrations in breast milk.
Topics: Chromatography, High Pressure Liquid; Female; HIV Infections; Humans; Infectious Disease Transmissio | 2007 |
An efficient tool for surveying CRF01_AE HIV type 1 resistance in Thailand to combined stavudine-lamivudine-nevirapine treatment: mutagenically separated PCR targeting M184I/V.
Topics: Anti-HIV Agents; Drug Resistance, Multiple, Viral; Drug Therapy, Combination; HIV Infections; HIV-1; | 2007 |
Determination of abacavir, amprenavir, didanosine, efavirenz, nevirapine, and stavudine concentration in human plasma by MALDI-TOF/TOF.
Topics: Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Carbamates; Cycloprop | 2008 |
Comparison of LigAmp and an ASPCR assay for detection and quantification of K103N-containing HIV variants.
Topics: Anti-HIV Agents; Base Sequence; Drug Resistance, Viral; Female; Genes, pol; Genetic Variation; HIV I | 2008 |
Enzymatic properties and sensitivity to inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase with Glu-138-->Arg and Tyr-188-->His mutations.
Topics: Amino Acids; Antiviral Agents; Base Sequence; Benzodiazepines; Benzoxazoles; Binding, Competitive; D | 1994 |
Rapid determination of nevirapine in human plasma by ion-pair reversed-phase high-performance liquid chromatography with ultraviolet detection.
Topics: Anti-HIV Agents; Chromatography, High Pressure Liquid; Humans; Nevirapine; Reproducibility of Result | 1998 |
Cost effectiveness of single-dose nevirapine regimen for mothers and babies to decrease vertical HIV-1 transmission in sub-Saharan Africa.
Topics: Africa South of the Sahara; Anti-HIV Agents; Cost-Benefit Analysis; Drug Administration Schedule; Fe | 1999 |
Validation of a high-performance liquid chromatography method for the assay of and determination of related organic impurities in nevirapine drug substance.
Topics: Chromatography, High Pressure Liquid; Drug Contamination; Drug Stability; Nevirapine; Pharmaceutical | 2000 |
A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics.
Topics: Antiviral Agents; Base Sequence; Cross-Sectional Studies; DNA Probes; Drug Resistance, Microbial; Ev | 2001 |
Simple and rapid determination of nevirapine in human serum by reversed-phase high-performance liquid chromatography.
Topics: Anti-HIV Agents; Calibration; Chromatography, High Pressure Liquid; Humans; Nevirapine; Reproducibil | 2001 |
Antiretrovirals: simultaneous determination of five protease inhibitors and three nonnucleoside transcriptase inhibitors in human plasma by a rapid high-performance liquid chromatography--mass spectrometry assay.
Topics: Alkynes; Benzoxazines; Carbamates; Chromatography, Liquid; Cyclopropanes; Delavirdine; Drug Monitori | 2001 |
High-performance liquid chromatographic assay to determine the plasma levels of HIV-protease inhibitors (amprenavir, indinavir, nelfinavir, ritonavir and saquinavir) and the non-nucleoside reverse transcriptase inhibitor (nevirapine) after liquid-liquid e
Topics: Calibration; Carbamates; Chromatography, High Pressure Liquid; Furans; HIV Protease Inhibitors; Huma | 2001 |
Rapid determination of nevirapine in human plasma by gas chromatography.
Topics: Chromatography, Gas; HIV Infections; Humans; Nevirapine; Reproducibility of Results; Reverse Transcr | 2002 |
Nevirapine quantification in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry. Application to bioequivalence study.
Topics: Adult; Area Under Curve; Chromatography, High Pressure Liquid; Female; Humans; Male; Middle Aged; Ne | 2002 |
Simple and rapid quantification of the non-nucleoside reverse transcriptase inhibitors nevirapine, delavirdine, and efavirenz in human blood plasma using high-performance liquid chromatography with ultraviolet absorbance detection.
Topics: Alkynes; Benzoxazines; Chromatography, High Pressure Liquid; Cyclopropanes; Delavirdine; HIV Infecti | 2002 |
Determination of lopinavir and nevirapine by high-performance liquid chromatography after solid-phase extraction: application for the assessment of their transplacental passage at delivery.
Topics: Calibration; Chromatography, High Pressure Liquid; Female; HIV Protease Inhibitors; Humans; Lopinavi | 2002 |