nevirapine has been researched along with Malaria, Falciparum in 11 studies
Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.
nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.
Malaria, Falciparum: Malaria caused by PLASMODIUM FALCIPARUM. This is the severest form of malaria and is associated with the highest levels of parasites in the blood. This disease is characterized by irregularly recurring febrile paroxysms that in extreme cases occur with acute cerebral, renal, or gastrointestinal manifestations.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Artemisinin-based combination therapies (ACTs) are the primary treatment for malaria." | 8.31 | Impact of Drug Exposure on Resistance Selection Following Artemether-Lumefantrine Treatment for Malaria in Children With and Without HIV in Uganda. ( Aweeka, F; Ehrlich, H; Freeman, T; French, J; Goodwin, J; Huang, L; Kajubi, R; Kay, K; Li, F; Mwebaza, N; Ou, J; Parikh, S; Riggs, M; Ruiz-Garcia, A; Wade, M; Wang, K, 2023) |
| " Dihydroartemisinin-piperaquine (DPQ) is recommended for treatment of Plasmodium falciparum malaria, but its efficacy and safety has not been evaluated in HIV-infected individuals on ART, among whom drug-drug interactions are expected." | 5.30 | Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium falciparum uncomplicated malaria in adult patients on antiretroviral therapy in Malawi and Mozambique: an open label non-randomized interventional trial. ( Banda, CG; Kalilani-Phiri, L; Khoo, SH; Lalloo, DG; Macuacua, S; Maculuve, S; Mallewa, J; Mukaka, M; Mwapasa, V; Piqueras, M; Sevene, E; Terlouw, DJ; Vala, A, 2019) |
| "Artemisinin-based combination therapies (ACTs) are the primary treatment for malaria." | 4.31 | Impact of Drug Exposure on Resistance Selection Following Artemether-Lumefantrine Treatment for Malaria in Children With and Without HIV in Uganda. ( Aweeka, F; Ehrlich, H; Freeman, T; French, J; Goodwin, J; Huang, L; Kajubi, R; Kay, K; Li, F; Mwebaza, N; Ou, J; Parikh, S; Riggs, M; Ruiz-Garcia, A; Wade, M; Wang, K, 2023) |
| " Infection with Plasmodium falciparum malaria was confirmed and treatment with quinine commenced together with amoxicillin/clavulanic acid and clarithromycin for possible respiratory infection." | 3.77 | Malaria therapy in HIV: drug interactions between nevirapine and quinine. ( Lewthwaite, P; Uriel, A, 2011) |
| "Nevirapine exposure was unchanged before and after artemether-lumefantrine administration." | 1.42 | Artemether-Lumefantrine Exposure in HIV-Infected Nigerian Subjects on Nevirapine-Containing Antiretroviral Therapy. ( Adedeji, WA; Adewole, IF; Akinyinka, OO; Aweeka, FT; Darin, KM; Fehintola, F; Huang, L; Morse, GD; Murphy, RL; Olson, A; Parikh, S; Scarsi, KK; Taiwo, BO, 2015) |
| " Our results demonstrate that the HIV PI lopinavir inhibits liver stage parasites at clinically relevant concentrations, that is, at drug levels achieved in HIV-infected patients on standard dosing regimens." | 1.39 | The effect of antiretrovirals on Plasmodium falciparum liver stages. ( Borkowsky, W; De La Vega, P; Duffy, PE; Hobbs, CV; Krzych, U; Penzak, SR; Sinnis, P; Van Vliet, J, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 9 (81.82) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Casano, G | 1 |
| Dumètre, A | 1 |
| Pannecouque, C | 1 |
| Hutter, S | 1 |
| Azas, N | 1 |
| Robin, M | 1 |
| Kay, K | 1 |
| Goodwin, J | 1 |
| Ehrlich, H | 1 |
| Ou, J | 1 |
| Freeman, T | 1 |
| Wang, K | 1 |
| Li, F | 1 |
| Wade, M | 1 |
| French, J | 1 |
| Huang, L | 2 |
| Aweeka, F | 1 |
| Mwebaza, N | 1 |
| Kajubi, R | 1 |
| Riggs, M | 1 |
| Ruiz-Garcia, A | 1 |
| Parikh, S | 3 |
| Sevene, E | 1 |
| Banda, CG | 1 |
| Mukaka, M | 1 |
| Maculuve, S | 1 |
| Macuacua, S | 1 |
| Vala, A | 1 |
| Piqueras, M | 1 |
| Kalilani-Phiri, L | 1 |
| Mallewa, J | 1 |
| Terlouw, DJ | 1 |
| Khoo, SH | 1 |
| Lalloo, DG | 1 |
| Mwapasa, V | 1 |
| Hobbs, CV | 3 |
| Tanaka, TQ | 1 |
| Muratova, O | 1 |
| Van Vliet, J | 2 |
| Borkowsky, W | 3 |
| Williamson, KC | 1 |
| Duffy, PE | 3 |
| Chijioke-Nwauche, I | 1 |
| van Wyk, A | 1 |
| Nwauche, C | 1 |
| Beshir, KB | 1 |
| Kaur, H | 1 |
| Sutherland, CJ | 1 |
| De La Vega, P | 1 |
| Penzak, SR | 1 |
| Krzych, U | 1 |
| Sinnis, P | 1 |
| Kayentao, K | 1 |
| Guirou, EA | 1 |
| Doumbo, OK | 1 |
| Venkatesan, M | 1 |
| Plowe, CV | 1 |
| Parsons, TL | 1 |
| Hendrix, CW | 1 |
| Nyunt, MM | 1 |
| Fehintola, F | 1 |
| Olson, A | 1 |
| Adedeji, WA | 1 |
| Darin, KM | 1 |
| Morse, GD | 1 |
| Murphy, RL | 1 |
| Taiwo, BO | 1 |
| Akinyinka, OO | 1 |
| Adewole, IF | 1 |
| Aweeka, FT | 1 |
| Scarsi, KK | 1 |
| Gabriel, EE | 1 |
| Kamthunzi, P | 1 |
| Tegha, G | 1 |
| Tauzie, J | 1 |
| Petzold, E | 1 |
| Barlow-Mosha, L | 1 |
| Chi, BH | 1 |
| Li, Y | 1 |
| Ilmet, T | 1 |
| Kirmse, B | 1 |
| Neal, J | 1 |
| Deygoo, N | 1 |
| Jean Philippe, P | 1 |
| Mofenson, L | 1 |
| Prescott, W | 1 |
| Chen, J | 1 |
| Musoke, P | 1 |
| Palumbo, P | 1 |
| Naniche, D | 1 |
| Lahuerta, M | 1 |
| Bardaji, A | 1 |
| Sigauque, B | 1 |
| Romagosa, C | 1 |
| Berenguera, A | 1 |
| Mandomando, I | 1 |
| David, C | 1 |
| Sanz, S | 1 |
| Aponte, J | 1 |
| Ordi, J | 1 |
| Alonso, P | 1 |
| Menendez, C | 1 |
| Uriel, A | 1 |
| Lewthwaite, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| P1060 Substudy Comparing Differences in Malaria Parasitemia by Real Time Quantitative PCR in HIV-Infected Infants and Children on PI-Based HAART Versus NNRTI-Based HAART[NCT00719602] | Early Phase 1 | 105 participants (Actual) | Interventional | 2009-08-31 | Completed | ||
| Effect of Intermittent Preventive Treatment (IPTp) With Sulfadoxine-Pyrimethamine Plus Insecticide Treated Nets, Delivered Through Antenatal Clinics for the Prevention of Malaria in Mozambican Pregnant Women[NCT00209781] | 1,028 participants | Interventional | 2003-08-31 | Active, not recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 trials available for nevirapine and Malaria, Falciparum
8 other studies available for nevirapine and Malaria, Falciparum
| Article | Year |
|---|---|
Anti-HIV and antiplasmodial activity of original flavonoid derivatives.
Topics: Anti-HIV Agents; Antimalarials; Cell Line; Cell Survival; Flavonoids; HIV; HIV Infections; Humans; M | 2010 |
Impact of Drug Exposure on Resistance Selection Following Artemether-Lumefantrine Treatment for Malaria in Children With and Without HIV in Uganda.
Topics: Antimalarials; Artemether; Artemether, Lumefantrine Drug Combination; Artemisinins; Child; Drug Comb | 2023 |
HIV treatments have malaria gametocyte killing and transmission blocking activity.
Topics: Animals; Anopheles; Anti-HIV Agents; Antimalarials; Dose-Response Relationship, Drug; HIV Protease I | 2013 |
HIV-positive nigerian adults harbor significantly higher serum lumefantrine levels than HIV-negative individuals seven days after treatment for Plasmodium falciparum infection.
Topics: Adult; Anti-HIV Agents; Antimalarials; Antiretroviral Therapy, Highly Active; Artemether, Lumefantri | 2013 |
The effect of antiretrovirals on Plasmodium falciparum liver stages.
Topics: HIV Infections; HIV Protease Inhibitors; Humans; In Vitro Techniques; Liver; Lopinavir; Malaria, Fal | 2013 |
Preliminary study of quinine pharmacokinetics in pregnant women with malaria-HIV co-infection.
Topics: Adult; Anti-HIV Agents; Antimalarials; Antiretroviral Therapy, Highly Active; Coinfection; Drug Inte | 2014 |
Artemether-Lumefantrine Exposure in HIV-Infected Nigerian Subjects on Nevirapine-Containing Antiretroviral Therapy.
Topics: Adult; Anti-HIV Agents; Antimalarials; Artemether; Artemisinins; Case-Control Studies; Coinfection; | 2015 |
Malaria therapy in HIV: drug interactions between nevirapine and quinine.
Topics: Anti-HIV Agents; Antimalarials; Atovaquone; Drug Combinations; Drug Interactions; HIV Infections; Hu | 2011 |