nevirapine has been researched along with Liver Cirrhosis in 6 studies
Nevirapine: A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.
nevirapine : A dipyridodiazepine that is 5,11-dihydro-6H-dipyrido[3,2-b:2',3'-e][1,4]diazepine which is substituted by methyl, oxo, and cyclopropyl groups at positions 4, 6, and 11, respectively. A non-nucleoside reverse transcriptase inhibitor with activity against HIV-1, it is used in combination with other antiretrovirals for the treatment of HIV infection.
Liver Cirrhosis: Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nevirapine is a nonnucleoside reverse transcriptase inhibitor used as part of combination therapy for human immunodeficiency virus (HIV) infection." | 2.74 | Pharmacokinetic assessment of nevirapine and metabolites in human immunodeficiency virus type 1-infected patients with hepatic fibrosis. ( Cammett, AM; Felizarta, F; MacGregor, TR; Mallolas, J; Miailhes, P; Piliero, PJ; Wruck, JM, 2009) |
| " In an effort to understand whether NVP is metabolized differently in a transiently inflamed liver and whether a heightened immune response alters NVP-induced hepatic responses, female brown Norway rats were dosed with either vehicle or NVP alone (75 mg/kg/day for 15 days) or galactosamine alone (single intraperitoneal [ip] injection on day 7 to mimic viral hepatitis) or a combination of NVP (75/100/150 mg/kg/day for 15 days) and galactosamine (single 750 mg/kg ip on day 7)." | 1.43 | Drug-induced Liver Fibrosis: Testing Nevirapine in a Viral-like Liver Setting Using Histopathology, MALDI IMS, and Gene Expression. ( Arrington-Brown, L; Bailey, D; Brown, HR; Cariello, NF; Castellino, S; Elangbam, CS; Fowler, S; Gates, LD; Groseclose, MR; Krull, DL; Mellon-Kusibab, K; Miller, RT; Shah, V; Tillman, T; Yoon, LW, 2016) |
| "Most antiretrovirals are metabolized in the liver, and lower dosing could be advisable in patients with severe liver insufficiency." | 1.34 | Influence of liver fibrosis stage on plasma levels of antiretroviral drugs in HIV-infected patients with chronic hepatitis C. ( Barreiro, P; Gonzalez-Lahoz, J; Jiménez-Nácher, I; Labarga, P; Martín-Carbonero, L; Rodríguez-Novoa, S; Ruiz, A; Soriano, V, 2007) |
| "The stage of liver fibrosis was assessed by liver biopsy and/or elastography." | 1.33 | Severe liver disease associated with prolonged exposure to antiretroviral drugs. ( Babudieri, S; Barreiro, P; Garcia-Samaniego, J; González-Lahoz, J; Maida, I; Martín-Carbonero, L; Mura, MS; Núñez, M; Ríos, MJ; Rivas, P; Soriano, V; Sotgiu, G; Toro, C, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brown, HR | 1 |
| Castellino, S | 1 |
| Groseclose, MR | 1 |
| Elangbam, CS | 1 |
| Mellon-Kusibab, K | 1 |
| Yoon, LW | 1 |
| Gates, LD | 1 |
| Krull, DL | 1 |
| Cariello, NF | 1 |
| Arrington-Brown, L | 1 |
| Tillman, T | 1 |
| Fowler, S | 1 |
| Shah, V | 1 |
| Bailey, D | 1 |
| Miller, RT | 1 |
| Cammett, AM | 1 |
| MacGregor, TR | 1 |
| Wruck, JM | 1 |
| Felizarta, F | 1 |
| Miailhes, P | 1 |
| Mallolas, J | 1 |
| Piliero, PJ | 1 |
| Aranzabal, L | 1 |
| Casado, JL | 1 |
| Moya, J | 1 |
| Quereda, C | 1 |
| Diz, S | 1 |
| Moreno, A | 2 |
| Moreno, L | 1 |
| Antela, A | 1 |
| Perez-Elias, MJ | 1 |
| Dronda, F | 1 |
| Marín, A | 1 |
| Hernandez-Ranz, F | 1 |
| Moreno, S | 1 |
| Maida, I | 1 |
| Núñez, M | 1 |
| Ríos, MJ | 1 |
| Martín-Carbonero, L | 2 |
| Sotgiu, G | 1 |
| Toro, C | 1 |
| Rivas, P | 1 |
| Barreiro, P | 2 |
| Mura, MS | 1 |
| Babudieri, S | 1 |
| Garcia-Samaniego, J | 1 |
| González-Lahoz, J | 2 |
| Soriano, V | 2 |
| Rodríguez-Novoa, S | 1 |
| Labarga, P | 1 |
| Ruiz, A | 1 |
| Jiménez-Nácher, I | 1 |
| Berenguer, J | 1 |
| Bellón, JM | 1 |
| Miralles, P | 1 |
| Alvarez, E | 1 |
| Castillo, I | 1 |
| Cosín, J | 1 |
| López, JC | 1 |
| Sánchez Conde, M | 1 |
| Padilla, B | 1 |
| Resino, S | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Hepatic Safety of Currently Used Antiretroviral Regimens in HIV-infected Patients With Chronic Hepatitis B and/or Hepatitis C Under Real Life Conditions: The HEPAVIR HEPATIC SAFETY Cohort.[NCT01908660] | 192 participants (Actual) | Observational [Patient Registry] | 2007-01-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for nevirapine and Liver Cirrhosis
| Article | Year |
|---|---|
Pharmacokinetic assessment of nevirapine and metabolites in human immunodeficiency virus type 1-infected patients with hepatic fibrosis.
Topics: Adult; Aged; Anti-HIV Agents; Female; HIV Infections; HIV-1; Humans; Liver Cirrhosis; Male; Middle A | 2009 |
5 other studies available for nevirapine and Liver Cirrhosis
| Article | Year |
|---|---|
Drug-induced Liver Fibrosis: Testing Nevirapine in a Viral-like Liver Setting Using Histopathology, MALDI IMS, and Gene Expression.
Topics: Animals; Antiviral Agents; Female; Galactosamine; Gene Expression Profiling; Histocytochemistry; Liv | 2016 |
Influence of liver fibrosis on highly active antiretroviral therapy-associated hepatotoxicity in patients with HIV and hepatitis C virus coinfection.
Topics: Adult; Alkynes; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Chemical and D | 2005 |
Severe liver disease associated with prolonged exposure to antiretroviral drugs.
Topics: Adult; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Ascites; Budd-Chiari Syndrome; Case-C | 2006 |
Influence of liver fibrosis stage on plasma levels of antiretroviral drugs in HIV-infected patients with chronic hepatitis C.
Topics: Adult; Alkynes; Anti-HIV Agents; Atazanavir Sulfate; Benzoxazines; Cyclopropanes; Drug Monitoring; F | 2007 |
Association between exposure to nevirapine and reduced liver fibrosis progression in patients with HIV and hepatitis C virus coinfection.
Topics: Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Cross-Sectional Studies; Cyclopropanes; Disease Progr | 2008 |