neuropeptide-y and Neurotic-Disorders

Psychiatric genetics has been hampered by the fact that initially exciting findings from underpowered studies are so often not replicated in larger, more powerful, data sets. Here we show that the claims of Zhou et al. that neuropeptide Y (NPY) diplotype-predicted expression is correlated with trait anxiety (neuroticism) is not replicated in a data set consisting of phenotypically extreme individuals drawn from a large (n = 88,142) non-clinical population. We found no association between NPY diplotype or diplotype-predicted expression and neuroticism. Our reply to Zhou and colleagues forms part of a larger debate (see, for example, http://www.nature.com/news/2008/080709/full/454154a.html) about the efficacy and replicability of candidate driven versus genome wide approaches to psychiatric genetics.

Topics: Genotype; Humans; Neuropeptide Y; Neurotic Disorders; Polymorphism, Single Nucleotide; Reproducibility of Results

Decreased plasma levels of plasma-neuropeptide Y (NPY) and plasma-corticotropin releasing hormone (CRH), and increased levels of plasma delta-sleep inducing peptide (DSIP) in suicide attempters with mood disorders have previously been observed. This study was performed in order to further understand the clinical relevance of these findings.. Examination of correlates between temperament dimensions (Karolinska Scales of Personality (KSP), the Eysenck Personality Questionnaire together with the IVE- impulsiveness scale (EPQI), and the Marke-Nyman Temperament (MNT)) and NPY, CRH and DSIP and serum-cortisol in the dexamethasone suppression test (DST) in 38 suicidal patients and matched controls.. NPY correlated significantly and positively with psychasthenia, irritability, and stability and significantly and negatively with validity in patients, but significantly and negatively with muscular tension, psychasthenia, verbal aggression and irritability in controls. DSIP correlated significantly and positively with impulsiveness (EPQI) in controls. CRH correlated negatively with lie in controls. Cortisol correlated significantly and positively with validity, extraversion and verbal aggression and significantly and negatively with inhibition of aggression in controls.. NPY may be related to stress tolerance. DSIP seems to be associated with impulsivity/antisocial traits.. Non-suicidal patients were not included in the examination.. The state of depression or stress seems to influence the correlations studied.

Topics: Adult; Case-Control Studies; Corticotropin-Releasing Hormone; Delta Sleep-Inducing Peptide; Dexamethasone; Female; Humans; Hydrocortisone; Hypothalamo-Hypophyseal System; Impulsive Behavior; Male; Matched-Pair Analysis; Middle Aged; Neuropeptide Y; Neuropeptides; Neurotic Disorders; Personality Tests; Pituitary-Adrenal System; Suicide, Attempted; Temperament