neuropeptide-y and Leukemia--Monocytic--Acute

neuropeptide-y has been researched along with Leukemia--Monocytic--Acute* in 1 studies

Other Studies

1 other study(ies) available for neuropeptide-y and Leukemia--Monocytic--Acute

Article	Year
The neuropeptides α-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells. Journal of neuroimmunology, 2013, Jul-15, Volume: 260, Issue:1-2 Within the immunosuppressive ocular microenvironment, there are constitutively present the immunomodulating neuropeptides alpha-melanocyte stimulating hormone (α-MSH) and neuropeptide Y (NPY) that promote suppressor functionality in macrophages. In this study, we examined the possibility that α-MSH and NPY modulate phagocytic activity in macrophages. The macrophages treated with α-MSH and NPY were significantly suppressed in their capacity to phagocytize unopsonized Escherichia coli and Staphylococcus aureus bioparticles, but not antibody-opsonized bioparticles. The neuropeptides significantly suppressed phagolysosome activation, and the FcR-associated generation of reactive oxidative species as well. This suppression corresponds to neuropeptide modulation of macrophage functionality within the ocular microenvironment to suppress the activation of immunogenic inflammation. Topics: alpha-MSH; Animals; Cell Line, Tumor; Escherichia coli; Escherichia coli Infections; Leukemia, Monocytic, Acute; Macrophages; Mice; Neuroimmunomodulation; Neuropeptide Y; Phagocytosis; Phagosomes; Reactive Oxygen Species; Retina; Staphylococcal Infections; Staphylococcus aureus	2013

Article

Year

The neuropeptides α-MSH and NPY modulate phagocytosis and phagolysosome activation in RAW 264.7 cells.

Journal of neuroimmunology, 2013, Jul-15, Volume: 260, Issue:1-2

Within the immunosuppressive ocular microenvironment, there are constitutively present the immunomodulating neuropeptides alpha-melanocyte stimulating hormone (α-MSH) and neuropeptide Y (NPY) that promote suppressor functionality in macrophages. In this study, we examined the possibility that α-MSH and NPY modulate phagocytic activity in macrophages. The macrophages treated with α-MSH and NPY were significantly suppressed in their capacity to phagocytize unopsonized Escherichia coli and Staphylococcus aureus bioparticles, but not antibody-opsonized bioparticles. The neuropeptides significantly suppressed phagolysosome activation, and the FcR-associated generation of reactive oxidative species as well. This suppression corresponds to neuropeptide modulation of macrophage functionality within the ocular microenvironment to suppress the activation of immunogenic inflammation.

Topics: alpha-MSH; Animals; Cell Line, Tumor; Escherichia coli; Escherichia coli Infections; Leukemia, Monocytic, Acute; Macrophages; Mice; Neuroimmunomodulation; Neuropeptide Y; Phagocytosis; Phagosomes; Reactive Oxygen Species; Retina; Staphylococcal Infections; Staphylococcus aureus

2013