neuropeptide-y and Emphysema

Neuropeptide Y (NPY) is a neuropeptide widely expressed in not only the central nervous system but also immune cells and the respiratory epithelium. Patients with chronic obstructive pulmonary disease (COPD) reportedly exhibit decreased NPY expression in the airway epithelium, but the involvement of NPY in the pathophysiology of COPD has not been defined. We investigated the role of NPY in elastase-induced emphysema. NPY-deficient (NPY

Topics: Animals; Bronchoalveolar Lavage Fluid; Chemokines; Emphysema; Humans; Immunity, Innate; Lung; Lymphocytes; Mice; Mice, Inbred C57BL; Neuropeptide Y; Pancreatic Elastase; Pulmonary Emphysema; Swine