neuropeptide-y and Atrial-Fibrillation

We studied combined effect of the β

Topics: Adrenergic Agents; Animals; Atrial Fibrillation; Isoproterenol; Neuropeptide Y; Rats; Receptors, Neuropeptide Y

Topics: Atrial Fibrillation; Biomarkers; Humans; Neuropeptide Y

We detected distinct plasma concentration profiles of S100B, neuropeptide Y, and secretagogin in 3 of 191 patients enrolled in a previous study investigating brain-tissue-related markers in the blood of patients with atrial fibrillation. Intriguingly, 2 of these 3 patients, both of whom were without neurological symptoms at the time of blood sampling, were diagnosed with malignant glioma (MG) approximately 1 year later. To our knowledge, this is the first report indicating that distinct blood biomarker profiles may be detected long before clinical manifestation of MG.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Atrial Fibrillation; Biomarkers, Tumor; Brain Neoplasms; Calcium-Binding Proteins; Female; Glioma; Humans; Male; Middle Aged; Nerve Growth Factors; Neuropeptide Y; S100 Calcium Binding Protein beta Subunit; S100 Proteins; Secretagogins; Young Adult

Identification of plasma markers indicative for atrial fibrillation-associated silent brain lesions.. 1. Comparative determination of the plasma concentrations of secretagogin, S100B, neuropeptide Y, brain fatty acid binding protein, matrix metalloprotease 9, brain natriuretic peptide, and of D-Dimer in 222 patients with atrial fibrillation and 28 controls by immunoassays. 2. Correlation of the biochemical marker plasma concentration with the extent of silent white matter brain lesions, as determined by the Fazekas score and N-acetylaspartate-spectroscopy.. 1. Plasma concentrations of brain natriuretic peptide, of neuropeptide Y, and of matrix metalloprotease 9 were significantly higher (all with a p<0.05) in patients suffering from atrial fibrillation than in control subjects. 2. Brain natriuretic peptide correlated significantly with the Fazekas score (R=0.41; p<0.005). 3. Brain natriuretic peptide plasma concentrations were significantly higher in patients with a pathological N-acetylaspartate magnetic resonance-spectrometry (p<0.05).. Brain natriuretic peptide plasma concentrations correlate with the extent of atrial fibrillation-associated silent brain lesions.

Topics: Aged; Aged, 80 and over; Atrial Fibrillation; Biomarkers; Brain; Fibrin Fibrinogen Degradation Products; Humans; Magnetic Resonance Imaging; Male; Matrix Metalloproteinase 9; Middle Aged; Natriuretic Peptide, Brain; Neuropeptide Y; Risk Factors

One of the potential mechanisms to explain the occurrence of postoperative atrial fibrillation (AF) is imbalance of autonomic nervous system tone. The myocardium is innervated not only by cholinergic and adrenergic nerves but also by peptidergic nerves that synthesize and secrete neuropeptides. To investigate the possible role of cardiac neuropeptides in the development of AF after coronary artery bypass grafting (CABG), we analyzed the plasma levels of substance P (SubP), neuropeptide Y (NPY), and angiotensin II (Ang II) in patients who underwent elective on-pump CABG.. This prospective study group included 83 consecutive patients scheduled for elective, on-pump CABG. Depressed left ventricular (LV) function (ejection fraction [EF] less than 0.30), concomitant cardiac procedures, history of atrial fibrillation, second or third degree atrioventricular block, implanted pacemaker, postoperative myocardial infarction, use of class I or III antiarrhythmic drug, and hemodynamic deterioration were exclusion criteria. Preoperative and postoperative serum levels of SubP, NPY, and AngII were measured by radioimmunoassay technique.. Postoperative AF occurred in 27 patients (32.5%). Using multivariate logistic regression analyses, only a decrease in SubP level (odds ratio [OR] = 1.87, 95% confidence interval [CI] = 0.767 to 0.99, p = 0.031) and an increase in AngII level (OR = 2.61, 95% CI = 1.002 to 1.021, p = 0.023) after CABG were found to be independently associated with AF. Increased age (p = 0.02), diabetes mellitus (p = 0.023), preoperative use of beta blocker (p = 0.024), proximal right coronary artery involvement (p = 0.024), low preoperative sodium levels (p = 0.023), low LVEF (p = 0.013), and increased mitral E wave deceleration time (p = 0.044) were also associated with AF.. These results indicate that the increase in AngII and the decrease in SubP after CABG may play a role in the occurrence of postoperative AF. Further studies are needed to define the physiologic and pathologic relevance of these substances at the occurrence of AF in patients who undergo CABG.

Topics: Adrenergic beta-Antagonists; Aging; Angiotensin II; Atrial Fibrillation; Coronary Artery Bypass; Diabetes Complications; Echocardiography; Female; Humans; Male; Middle Aged; Mitral Valve; Myocardium; Neuropeptide Y; Postoperative Period; Prospective Studies; Sodium; Stroke Volume; Substance P