netilmicin and Drug-Hypersensitivity

Noma has virtually disappeared from Europe, but is still found in certain parts of Africa, South America and Asia. In our case the etiologic agent was Pseudomonas aeruginosa sensitive to antibiotic therapy that we used (pefloxacin and netilmicin). Another characteristic aspect of our case is the rapid infaust evolution. In this report will be discuss the pathogenesis and the reason of the failure of the antibiotic therapy especially in immunodeficiency patients.

Topics: 4-Quinolones; Acute Disease; Adult; Anti-Infective Agents; Drug Hypersensitivity; Drug Therapy, Combination; Female; Fluoroquinolones; Humans; Leukemia, Myeloid; Netilmicin; Noma; Pefloxacin; Penicillins; Pseudomonas Infections; Quinolones

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Cefotaxime; Drug Hypersensitivity; Drug Resistance; Drug Therapy, Combination; Female; Humans; Injections, Intravenous; Male; Middle Aged; Netilmicin; Treatment Outcome

Neomycin sensitive patients were tested for hypersensitivity to kanamycin, gentamycin, tobramycin, spectinomycin and to the new, not yet registered sisomycin and netilmicin. Cross-sensitivity occured in a considerable part of the patients, except for spectinomycin, the structure of which is basically different from that of the other aminoglycosides tested. The common occurence of cross-sensitivity between neomycin and other aminoglycoside antibiotics shows that it is possible to predict cross-sensitivity between a new drug and an old sensitizing one before clinical reactions from the new drug have occured. Such an investigation should be performed before adopting new antibiotics.

Topics: Aminoglycosides; Anti-Bacterial Agents; Cross Reactions; Drug Hypersensitivity; Gentamicins; Humans; Kanamycin; Neomycin; Netilmicin; Sisomicin; Spectinomycin; Tobramycin