netilmicin and Brain-Abscess

The first-line treatment for brain abscesses is still a much-debated argument. Recently, stereotactic aspiration of these lesions has gained ground as a valid alternative to the traditional medical and/or surgical therapeutical treatments. From 1991 to 1995, 9 patients affected by intracranial abscesses were surgically treated by stereotactic puncture of the lesion and drainage of pus, using the Kelly-Goerss stereotactic system. Multiple abscesses were present in one case. Specific antibiotic therapy was used in the post-operative stage, when possible. One death occurred four weeks after surgery for acute ischemia of the brain stem. Follow-up CT demonstrated gradual resolution of the abscesses in all the cases and a successful return to normal daily life in all the surviving patients. In one case, recurrence of the abscess occurred two months after resolution: a successful result was obtained by steroids and broad-spectrum antibiotic therapy alone. Possible advantages of this technique are discussed and compared with the traditional routes. The literature concerning this argument is reviewed.

Topics: Adolescent; Adult; Aged; Brain Abscess; Catheterization, Peripheral; Ceftriaxone; Cephalosporins; Drainage; Drug Therapy, Combination; Follow-Up Studies; Gentamicins; Humans; Male; Middle Aged; Netilmicin; Phenobarbital; Postoperative Care; Recurrence; Stereotaxic Techniques; Tomography, X-Ray Computed; Treatment Outcome