netilmicin and Alkalosis

netilmicin has been researched along with Alkalosis* in 1 studies

Other Studies

1 other study(ies) available for netilmicin and Alkalosis

Article	Year
Evaluation of distal tubular function in aminoglycoside-induced nephropathy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1987, Volume: 20, Issue:6 Acute metabolic acidosis potentiates the nephrotoxicity of aminoglycosides by impairing the adequate excretion of ammonium and titratable acidity. The present study assesses distal tubular function after aminoglycoside administration in the rat. Two aminoglycosides, gentamicin and netilmycin were given to rats either in low doses equivalent to those used clinically (BG4 and BN5 groups) or in doses ten times higher (BG40 and BN50). The rats were subjected to acute metabolic alkalosis and the pCO2 of urine was continuously evaluated. The regression lines obtained by plotting the differences between urine and blood pCO2 as a function of urinary HCO3- in low dose models were similar to those obtained for the control group. However, the slopes obtained for BG40 and BN50 were significantly different from the control, suggesting an impairment of H+ secretion. Topics: Acidosis, Renal Tubular; Alkalosis; Animals; Carbon Dioxide; Gentamicins; Kidney Tubules; Kidney Tubules, Distal; Netilmicin; Rats; Regression Analysis	1987

Article

Year

Evaluation of distal tubular function in aminoglycoside-induced nephropathy.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1987, Volume: 20, Issue:6

Acute metabolic acidosis potentiates the nephrotoxicity of aminoglycosides by impairing the adequate excretion of ammonium and titratable acidity. The present study assesses distal tubular function after aminoglycoside administration in the rat. Two aminoglycosides, gentamicin and netilmycin were given to rats either in low doses equivalent to those used clinically (BG4 and BN5 groups) or in doses ten times higher (BG40 and BN50). The rats were subjected to acute metabolic alkalosis and the pCO2 of urine was continuously evaluated. The regression lines obtained by plotting the differences between urine and blood pCO2 as a function of urinary HCO3- in low dose models were similar to those obtained for the control group. However, the slopes obtained for BG40 and BN50 were significantly different from the control, suggesting an impairment of H+ secretion.

Topics: Acidosis, Renal Tubular; Alkalosis; Animals; Carbon Dioxide; Gentamicins; Kidney Tubules; Kidney Tubules, Distal; Netilmicin; Rats; Regression Analysis

1987