netilmicin and Acidosis--Renal-Tubular

netilmicin has been researched along with Acidosis--Renal-Tubular* in 2 studies

Other Studies

2 other study(ies) available for netilmicin and Acidosis--Renal-Tubular

Article	Year
Evaluation of distal tubular function in aminoglycoside-induced nephropathy. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1987, Volume: 20, Issue:6 Acute metabolic acidosis potentiates the nephrotoxicity of aminoglycosides by impairing the adequate excretion of ammonium and titratable acidity. The present study assesses distal tubular function after aminoglycoside administration in the rat. Two aminoglycosides, gentamicin and netilmycin were given to rats either in low doses equivalent to those used clinically (BG4 and BN5 groups) or in doses ten times higher (BG40 and BN50). The rats were subjected to acute metabolic alkalosis and the pCO2 of urine was continuously evaluated. The regression lines obtained by plotting the differences between urine and blood pCO2 as a function of urinary HCO3- in low dose models were similar to those obtained for the control group. However, the slopes obtained for BG40 and BN50 were significantly different from the control, suggesting an impairment of H+ secretion. Topics: Acidosis, Renal Tubular; Alkalosis; Animals; Carbon Dioxide; Gentamicins; Kidney Tubules; Kidney Tubules, Distal; Netilmicin; Rats; Regression Analysis	1987
Aminoglycosides and renal acid excretion. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1986, Volume: 19, Issue:3 The effect of three aminoglycosides, gentamicin, netilmicin and amikacin, on renal acid excretion was studied in rats treated with doses equivalent to 10 times those used clinically. The gentamicin and amikacin groups showed a marked decrease (P less than 0.05), in glomerular filtration rate (GFR), U/P inulin ratio and renal plasma flow (RPF), while in the normal acid-base state. Under acidotic conditions, only gentamicin promoted significant alterations in GFR and RPF. Net acid excretion as measured by the acid balance (BH) was calculated as the sum of ammonium excretion (NH4+) and titratable acidity (AT) minus the amount of excreted bicarbonate (CHCO3-). Under normal conditions, netilmicin promoted a considerable fall in both NH4+ and AT, which led to a significant decrease in BH, whereas no changes were observed in these parameters with the other two drugs. In contrast, during acute metabolic acidosis, all tested antibiotics promoted a marked fall in BH, particularly due to a significant decrease in NH4+ and AT. These data suggest that the effects of aminoglycoside treatment during acute metabolic acidosis in clinical practice deserve further study in view of possible deleterious effects on the clinical state. Topics: Acidosis, Renal Tubular; Amikacin; Animals; Gentamicins; Glomerular Filtration Rate; Kidney; Male; Netilmicin; Rats	1986

Article

Year

Evaluation of distal tubular function in aminoglycoside-induced nephropathy.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1987, Volume: 20, Issue:6

Acute metabolic acidosis potentiates the nephrotoxicity of aminoglycosides by impairing the adequate excretion of ammonium and titratable acidity. The present study assesses distal tubular function after aminoglycoside administration in the rat. Two aminoglycosides, gentamicin and netilmycin were given to rats either in low doses equivalent to those used clinically (BG4 and BN5 groups) or in doses ten times higher (BG40 and BN50). The rats were subjected to acute metabolic alkalosis and the pCO2 of urine was continuously evaluated. The regression lines obtained by plotting the differences between urine and blood pCO2 as a function of urinary HCO3- in low dose models were similar to those obtained for the control group. However, the slopes obtained for BG40 and BN50 were significantly different from the control, suggesting an impairment of H+ secretion.

Topics: Acidosis, Renal Tubular; Alkalosis; Animals; Carbon Dioxide; Gentamicins; Kidney Tubules; Kidney Tubules, Distal; Netilmicin; Rats; Regression Analysis

1987

Aminoglycosides and renal acid excretion.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 1986, Volume: 19, Issue:3

The effect of three aminoglycosides, gentamicin, netilmicin and amikacin, on renal acid excretion was studied in rats treated with doses equivalent to 10 times those used clinically. The gentamicin and amikacin groups showed a marked decrease (P less than 0.05), in glomerular filtration rate (GFR), U/P inulin ratio and renal plasma flow (RPF), while in the normal acid-base state. Under acidotic conditions, only gentamicin promoted significant alterations in GFR and RPF. Net acid excretion as measured by the acid balance (BH) was calculated as the sum of ammonium excretion (NH4+) and titratable acidity (AT) minus the amount of excreted bicarbonate (CHCO3-). Under normal conditions, netilmicin promoted a considerable fall in both NH4+ and AT, which led to a significant decrease in BH, whereas no changes were observed in these parameters with the other two drugs. In contrast, during acute metabolic acidosis, all tested antibiotics promoted a marked fall in BH, particularly due to a significant decrease in NH4+ and AT. These data suggest that the effects of aminoglycoside treatment during acute metabolic acidosis in clinical practice deserve further study in view of possible deleterious effects on the clinical state.

Topics: Acidosis, Renal Tubular; Amikacin; Animals; Gentamicins; Glomerular Filtration Rate; Kidney; Male; Netilmicin; Rats

1986