neriifolin has been researched along with Liver-Neoplasms* in 1 studies
1 other study(ies) available for neriifolin and Liver-Neoplasms
| Article | Year |
|---|---|
Neriifolin from seeds of Cerbera manghas L. induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells.
The effects of neriifolin, a cardiac glycoside from Cerbera manghas L. on various end-points of oncologic relevance (cell growth, cell cycle regulation, and apoptosis in HepG2 cells) were investigated. Neriifolin reduced viability of HepG2 cells, induced S and G2/M phase arrests of the cell cycle, and stimulated apoptosis of HepG2 cells. Stimulation of HepG2 cells with neriifolin induced activation of caspase-3, -8, and -9, and up-regulated expression of Fas and FasL proteins. Based on these results, neriifolin could be considered a candidate for the treatment of hepatocellular carcinoma. Topics: Antineoplastic Agents, Phytogenic; Apocynaceae; Apoptosis; Carcinoma, Hepatocellular; Cardenolides; Caspases; Cell Cycle; Fas Ligand Protein; Fas-Associated Death Domain Protein; Hep G2 Cells; Humans; Liver Neoplasms; Phytotherapy; Plant Extracts; Seeds; Up-Regulation | 2011 |