neramexane and Epilepsy

neramexane has been researched along with Epilepsy* in 1 studies

Other Studies

1 other study(ies) available for neramexane and Epilepsy

Article	Year
Effect of low-affinity NMDA receptor antagonists on electrical activity in mouse cortical slices. European journal of pharmacology, 2002, May-17, Volume: 443, Issue:1-3 The objective of this study was to investigate the effects of three low-affinity NMDA receptor antagonists, MRZ 2/279 (1-amino-1,3,3,5,5-pentamethyl-cyclohexane HCl), AR-R 15896AR ([+]-alpha-phenyl-2-pyridine-ethanamine diHCl) and dextromethorphan on epileptiform activity in vitro. Epileptiform discharges were elicited in DBA/2 mouse cortical slices by perfusion with Mg(2+)-free artificial cerebrospinal fluid. MRZ 2/279, AR-R 15896AR and dextromethorphan all reversibly decreased the frequency of the discharges in a concentration-dependent manner. The IC(50)'s for MRZ 2/279, AR-R 15896AR and dextromethorphan were 5.2, 10.8 and 55.9 microM, respectively. These low-affinity NMDA receptor antagonists may be proved to be clinically effective with fewer adverse effects than drugs with high-affinity for the NMDA receptor-operated channel. Topics: Animals; Cerebral Cortex; Cyclopentanes; Dextromethorphan; Electric Conductivity; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Pyridines; Receptors, N-Methyl-D-Aspartate	2002

Article

Year

Effect of low-affinity NMDA receptor antagonists on electrical activity in mouse cortical slices.

European journal of pharmacology, 2002, May-17, Volume: 443, Issue:1-3

The objective of this study was to investigate the effects of three low-affinity NMDA receptor antagonists, MRZ 2/279 (1-amino-1,3,3,5,5-pentamethyl-cyclohexane HCl), AR-R 15896AR ([+]-alpha-phenyl-2-pyridine-ethanamine diHCl) and dextromethorphan on epileptiform activity in vitro. Epileptiform discharges were elicited in DBA/2 mouse cortical slices by perfusion with Mg(2+)-free artificial cerebrospinal fluid. MRZ 2/279, AR-R 15896AR and dextromethorphan all reversibly decreased the frequency of the discharges in a concentration-dependent manner. The IC(50)'s for MRZ 2/279, AR-R 15896AR and dextromethorphan were 5.2, 10.8 and 55.9 microM, respectively. These low-affinity NMDA receptor antagonists may be proved to be clinically effective with fewer adverse effects than drugs with high-affinity for the NMDA receptor-operated channel.

Topics: Animals; Cerebral Cortex; Cyclopentanes; Dextromethorphan; Electric Conductivity; Electrophysiology; Epilepsy; Excitatory Amino Acid Antagonists; Female; In Vitro Techniques; Male; Mice; Mice, Inbred DBA; Pyridines; Receptors, N-Methyl-D-Aspartate

2002