Page last updated: 2024-10-31

neostigmine and Seizures

neostigmine has been researched along with Seizures in 21 studies

Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.

Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.

Research Excerpts

ExcerptRelevanceReference
"Neostigmine methylsulfate has a quaternary ammonium group, which prevents its penetration through the blood-brain barrier; hence its primary influence is believed to be due to its action on the peripheral nervous system."5.31A female with central anticholinergic syndrome responsive to neostigmine. ( Francia, A; Parisi, P, 2000)
" The electrical stimulation of NC inhibits seizures in Am induced by the administration of picrotoxin into this nucleus."3.65The influence of neuromediators injected into nucleus caudatus on bioelectrical seizure activity of amygdala. ( Stach, R, 1976)
"Sensitivity to several convulsion endpoints induced by nicotine, carbachol, and neostigmine were significantly greater in WSR versus WSP mice."1.31The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in withdrawal seizure-prone and withdrawal seizure-resistant selected mouse lines. ( Finn, DA; Mark, GP, 2002)
"Neostigmine methylsulfate has a quaternary ammonium group, which prevents its penetration through the blood-brain barrier; hence its primary influence is believed to be due to its action on the peripheral nervous system."1.31A female with central anticholinergic syndrome responsive to neostigmine. ( Francia, A; Parisi, P, 2000)
"When soman (2 X LD50) was given to TAB (an antidotal mixture of trimedoxime, atropine, and benactyzine ) pretreated rats, there was a greater than twofold reduction of glucose use in almost every brain region."1.27Soman induced changes in brain regional glucose use. ( Cross, RS; Giesler, MP; McDonough, JH; Mewes, K; Nelson, SR; Pazdernik, TL; Samson, FE, 1984)
"Neostigmine was injected intracerebrally into the amygdala of the cebus monkey with chronically implanted "chemitrodes" fitted with EEG recording electrodes."1.26Neostigmine activated epileptiform discharge in the amygdala: electrographic-behavioral correlations. ( Girgis, M, 1978)

Research

Studies (21)

TimeframeStudies, this research(%)All Research%
pre-199018 (85.71)18.7374
1990's1 (4.76)18.2507
2000's2 (9.52)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mark, GP1
Finn, DA1
WILSON, TM1
ZABLOCKA, B1
WEBSTER, JL1
PICKERING, D1
GREEN, VA1
Kryzhanovskiĭ, GN1
Shandra, AA1
Godlevskiĭ, LS1
Beliaeva, AI1
Samson, FE1
Pazdernik, TL1
Cross, RS1
Giesler, MP1
Mewes, K1
Nelson, SR1
McDonough, JH1
Parisi, P1
Francia, A1
Stach, R1
Girgis, M1
Rastogi, SK1
Puri, JN1
Sinha, JN1
Bhargava, KP1
Miller, JW1
Gray, BC1
Bardgett, ME1
Domino, EF2
Ferguson, JH1
Jasper, HH1
Hubbard, JH1
Rayport, M1
Bharucha, AD1
Elliott, KA1
Shellenberger, MK1
György, L1
Döda, M1
Hamburg, MD1
Fulton, DR1
Chichery, R1
Chanelet, J1
Lewis, DJ1
Bregman, NJ1

Other Studies

21 other studies available for neostigmine and Seizures

ArticleYear
The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in withdrawal seizure-prone and withdrawal seizure-resistant selected mouse lines.
    Alcoholism, clinical and experimental research, 2002, Volume: 26, Issue:8

    Topics: Acetylcholine; Alcohol Withdrawal Seizures; Animals; Carbachol; Cholinergic Agents; Convulsants; Hip

2002
Tonic convulsions and cardiovascular collapse following an injection of prostigmin.
    American journal of obstetrics and gynecology, 1954, Volume: 67, Issue:3

    Topics: Amenorrhea; Female; Humans; Injections; Neostigmine; Seizures

1954
Effects of autonomic agents, alone and in combination with antiepileptic drugs, on electroshock seizures in rats.
    Archives internationales de pharmacodynamie et de therapie, 1963, Apr-01, Volume: 142

    Topics: Animals; Anticonvulsants; Atropine; Autonomic Agents; Electroshock; Methacholine Compounds; Neostigm

1963
ACUTE MUSHROOM POISONING: TREATMENT WITH CURARE AND INTERMITTENT POSITIVE PRESSURE RESPIRATION.
    Clinical pediatrics, 1964, Volume: 3

    Topics: Agaricales; Atropine; Child; Curare; Drug Therapy; Edema; Gastric Lavage; Mushroom Poisoning; Neosti

1964
ALTERATIONS IN THE ACTIVITY OF PENTOTHAL, PHENOBARBITAL, PENTYLENETETRAZOL, AND STRYCHNINE BY CHOLINESTERASE INHIBITORS.
    Journal of pharmaceutical sciences, 1964, Volume: 53

    Topics: Acetylcholine; Anesthesia; Atropine; Cholinesterase Inhibitors; Isoflurophate; Mice; Neostigmine; Pe

1964
[Further study of the antiepileptic properties of nicotinamide].
    Biulleten' eksperimental'noi biologii i meditsiny, 1981, Volume: 91, Issue:1

    Topics: 3-Mercaptopropionic Acid; Acetylcholine; Animals; Anticonvulsants; Brain; Cats; gamma-Aminobutyric A

1981
Soman induced changes in brain regional glucose use.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1984, Volume: 4, Issue:2 Pt 2

    Topics: Animals; Atropine; Benactyzine; Brain; Cholinesterase Inhibitors; Deoxyglucose; Echothiophate Iodide

1984
A female with central anticholinergic syndrome responsive to neostigmine.
    Pediatric neurology, 2000, Volume: 23, Issue:2

    Topics: Ataxia; Blood-Brain Barrier; Child, Preschool; Cholinesterase Inhibitors; Female; Hallucinations; Hu

2000
The influence of neuromediators injected into nucleus caudatus on bioelectrical seizure activity of amygdala.
    Polish journal of pharmacology and pharmacy, 1976, Volume: 28, Issue:2

    Topics: Amygdala; Animals; Caudate Nucleus; Dopamine; Electrodes, Implanted; Glutamates; Injections; Male; M

1976
Neostigmine activated epileptiform discharge in the amygdala: electrographic-behavioral correlations.
    Epilepsia, 1978, Volume: 19, Issue:5

    Topics: Aggression; Amygdala; Animals; Atropine; Electroencephalography; Haplorhini; Humans; Microinjections

1978
Involvement of central cholinoceptors in Metrazol-induced convulsions.
    Psychopharmacology, 1979, Volume: 65, Issue:2

    Topics: Animals; Atropine; Female; Male; Mecamylamine; Mice; Neostigmine; Parasympatholytics; Pentylenetetra

1979
Characterization of cholinergic regulation of seizures by the midline thalamus.
    Neuropharmacology, 1992, Volume: 31, Issue:4

    Topics: Animals; Female; Neostigmine; Nicotine; Parasympathomimetics; Pentylenetetrazole; Pilocarpine; Rats;

1992
Comparative seizure inducing properties of various cholinesterase inhibitors: antagonism by diazepam and midazolam.
    Neurotoxicology, 1987,Spring, Volume: 8, Issue:1

    Topics: Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Diazepam; Isoflurophate; Male; Midaz

1987
Laminar DC studies of acetylcholine-activated epileptiform discharge in cerebral cortex.
    Electroencephalography and clinical neurophysiology, 1971, Volume: 30, Issue:5

    Topics: Acetylcholine; Animals; Arousal; Cats; Cerebral Cortex; Electrodes; Electroencephalography; Membrane

1971
Cholinergic induction of thalamo-cortical seizures in cats.
    Electroencephalography and clinical neurophysiology, 1968, Volume: 24, Issue:2

    Topics: Acetylcholine; Animals; Animals, Newborn; Cats; Cerebral Cortex; Electrophysiology; Mesencephalon; N

1968
Effects of electrically induced convulsions and transmitter substances on ribonucleic acid turnover in brain slices.
    Experimental brain research, 1974, Jan-31, Volume: 19, Issue:2

    Topics: Acetylcholine; Aminobutyrates; Animals; Cerebral Cortex; DNA-Directed RNA Polymerases; Electric Stim

1974
Observations on intraventricular hemicholinium-3-induced EEG seizures.
    International journal of neuropharmacology, 1967, Volume: 6, Issue:4

    Topics: Acetylcholinesterase; Animals; Atropine; Biphenyl Compounds; Brain; Brain Chemistry; Cerebral Ventri

1967
Effect of cholinesterase inhibitors on the susceptibility to pentetrazole of the mouse.
    Acta physiologica Academiae Scientiarum Hungaricae, 1974, Volume: 45, Issue:3-4

    Topics: Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; F

1974
Influence of recall on an anticholinesterase induced retrograde amnesia.
    Physiology & behavior, 1972, Volume: 9, Issue:3

    Topics: Amnesia; Animals; Avoidance Learning; Electroshock; Fear; Humans; Injections, Subcutaneous; Male; Me

1972
[Effects observed in cuttle-fish after atropine or neostigmine injection].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1973, Volume: 167, Issue:2

    Topics: Animals; Atropine; Lethal Dose 50; Mollusca; Muscle Tonus; Neostigmine; Pigmentation; Respiration; S

1973
The cholinergic system, amnesia and memory.
    Physiology & behavior, 1972, Volume: 8, Issue:3

    Topics: Amnesia; Animals; Avoidance Learning; Electroshock; Humans; Male; Memory; Neostigmine; Physostigmine

1972