neostigmine has been researched along with Seizures in 21 studies
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neostigmine methylsulfate has a quaternary ammonium group, which prevents its penetration through the blood-brain barrier; hence its primary influence is believed to be due to its action on the peripheral nervous system." | 5.31 | A female with central anticholinergic syndrome responsive to neostigmine. ( Francia, A; Parisi, P, 2000) |
| " The electrical stimulation of NC inhibits seizures in Am induced by the administration of picrotoxin into this nucleus." | 3.65 | The influence of neuromediators injected into nucleus caudatus on bioelectrical seizure activity of amygdala. ( Stach, R, 1976) |
| "Sensitivity to several convulsion endpoints induced by nicotine, carbachol, and neostigmine were significantly greater in WSR versus WSP mice." | 1.31 | The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in withdrawal seizure-prone and withdrawal seizure-resistant selected mouse lines. ( Finn, DA; Mark, GP, 2002) |
| "Neostigmine methylsulfate has a quaternary ammonium group, which prevents its penetration through the blood-brain barrier; hence its primary influence is believed to be due to its action on the peripheral nervous system." | 1.31 | A female with central anticholinergic syndrome responsive to neostigmine. ( Francia, A; Parisi, P, 2000) |
| "When soman (2 X LD50) was given to TAB (an antidotal mixture of trimedoxime, atropine, and benactyzine ) pretreated rats, there was a greater than twofold reduction of glucose use in almost every brain region." | 1.27 | Soman induced changes in brain regional glucose use. ( Cross, RS; Giesler, MP; McDonough, JH; Mewes, K; Nelson, SR; Pazdernik, TL; Samson, FE, 1984) |
| "Neostigmine was injected intracerebrally into the amygdala of the cebus monkey with chronically implanted "chemitrodes" fitted with EEG recording electrodes." | 1.26 | Neostigmine activated epileptiform discharge in the amygdala: electrographic-behavioral correlations. ( Girgis, M, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 18 (85.71) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 2 (9.52) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mark, GP | 1 |
| Finn, DA | 1 |
| WILSON, TM | 1 |
| ZABLOCKA, B | 1 |
| WEBSTER, JL | 1 |
| PICKERING, D | 1 |
| GREEN, VA | 1 |
| Kryzhanovskiĭ, GN | 1 |
| Shandra, AA | 1 |
| Godlevskiĭ, LS | 1 |
| Beliaeva, AI | 1 |
| Samson, FE | 1 |
| Pazdernik, TL | 1 |
| Cross, RS | 1 |
| Giesler, MP | 1 |
| Mewes, K | 1 |
| Nelson, SR | 1 |
| McDonough, JH | 1 |
| Parisi, P | 1 |
| Francia, A | 1 |
| Stach, R | 1 |
| Girgis, M | 1 |
| Rastogi, SK | 1 |
| Puri, JN | 1 |
| Sinha, JN | 1 |
| Bhargava, KP | 1 |
| Miller, JW | 1 |
| Gray, BC | 1 |
| Bardgett, ME | 1 |
| Domino, EF | 2 |
| Ferguson, JH | 1 |
| Jasper, HH | 1 |
| Hubbard, JH | 1 |
| Rayport, M | 1 |
| Bharucha, AD | 1 |
| Elliott, KA | 1 |
| Shellenberger, MK | 1 |
| György, L | 1 |
| Döda, M | 1 |
| Hamburg, MD | 1 |
| Fulton, DR | 1 |
| Chichery, R | 1 |
| Chanelet, J | 1 |
| Lewis, DJ | 1 |
| Bregman, NJ | 1 |
21 other studies available for neostigmine and Seizures
| Article | Year |
|---|---|
The relationship between hippocampal acetylcholine release and cholinergic convulsant sensitivity in withdrawal seizure-prone and withdrawal seizure-resistant selected mouse lines.
Topics: Acetylcholine; Alcohol Withdrawal Seizures; Animals; Carbachol; Cholinergic Agents; Convulsants; Hip | 2002 |
Tonic convulsions and cardiovascular collapse following an injection of prostigmin.
Topics: Amenorrhea; Female; Humans; Injections; Neostigmine; Seizures | 1954 |
Effects of autonomic agents, alone and in combination with antiepileptic drugs, on electroshock seizures in rats.
Topics: Animals; Anticonvulsants; Atropine; Autonomic Agents; Electroshock; Methacholine Compounds; Neostigm | 1963 |
ACUTE MUSHROOM POISONING: TREATMENT WITH CURARE AND INTERMITTENT POSITIVE PRESSURE RESPIRATION.
Topics: Agaricales; Atropine; Child; Curare; Drug Therapy; Edema; Gastric Lavage; Mushroom Poisoning; Neosti | 1964 |
ALTERATIONS IN THE ACTIVITY OF PENTOTHAL, PHENOBARBITAL, PENTYLENETETRAZOL, AND STRYCHNINE BY CHOLINESTERASE INHIBITORS.
Topics: Acetylcholine; Anesthesia; Atropine; Cholinesterase Inhibitors; Isoflurophate; Mice; Neostigmine; Pe | 1964 |
[Further study of the antiepileptic properties of nicotinamide].
Topics: 3-Mercaptopropionic Acid; Acetylcholine; Animals; Anticonvulsants; Brain; Cats; gamma-Aminobutyric A | 1981 |
Soman induced changes in brain regional glucose use.
Topics: Animals; Atropine; Benactyzine; Brain; Cholinesterase Inhibitors; Deoxyglucose; Echothiophate Iodide | 1984 |
A female with central anticholinergic syndrome responsive to neostigmine.
Topics: Ataxia; Blood-Brain Barrier; Child, Preschool; Cholinesterase Inhibitors; Female; Hallucinations; Hu | 2000 |
The influence of neuromediators injected into nucleus caudatus on bioelectrical seizure activity of amygdala.
Topics: Amygdala; Animals; Caudate Nucleus; Dopamine; Electrodes, Implanted; Glutamates; Injections; Male; M | 1976 |
Neostigmine activated epileptiform discharge in the amygdala: electrographic-behavioral correlations.
Topics: Aggression; Amygdala; Animals; Atropine; Electroencephalography; Haplorhini; Humans; Microinjections | 1978 |
Involvement of central cholinoceptors in Metrazol-induced convulsions.
Topics: Animals; Atropine; Female; Male; Mecamylamine; Mice; Neostigmine; Parasympatholytics; Pentylenetetra | 1979 |
Characterization of cholinergic regulation of seizures by the midline thalamus.
Topics: Animals; Female; Neostigmine; Nicotine; Parasympathomimetics; Pentylenetetrazole; Pilocarpine; Rats; | 1992 |
Comparative seizure inducing properties of various cholinesterase inhibitors: antagonism by diazepam and midazolam.
Topics: Animals; Atropine; Behavior, Animal; Cholinesterase Inhibitors; Diazepam; Isoflurophate; Male; Midaz | 1987 |
Laminar DC studies of acetylcholine-activated epileptiform discharge in cerebral cortex.
Topics: Acetylcholine; Animals; Arousal; Cats; Cerebral Cortex; Electrodes; Electroencephalography; Membrane | 1971 |
Cholinergic induction of thalamo-cortical seizures in cats.
Topics: Acetylcholine; Animals; Animals, Newborn; Cats; Cerebral Cortex; Electrophysiology; Mesencephalon; N | 1968 |
Effects of electrically induced convulsions and transmitter substances on ribonucleic acid turnover in brain slices.
Topics: Acetylcholine; Aminobutyrates; Animals; Cerebral Cortex; DNA-Directed RNA Polymerases; Electric Stim | 1974 |
Observations on intraventricular hemicholinium-3-induced EEG seizures.
Topics: Acetylcholinesterase; Animals; Atropine; Biphenyl Compounds; Brain; Brain Chemistry; Cerebral Ventri | 1967 |
Effect of cholinesterase inhibitors on the susceptibility to pentetrazole of the mouse.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; F | 1974 |
Influence of recall on an anticholinesterase induced retrograde amnesia.
Topics: Amnesia; Animals; Avoidance Learning; Electroshock; Fear; Humans; Injections, Subcutaneous; Male; Me | 1972 |
[Effects observed in cuttle-fish after atropine or neostigmine injection].
Topics: Animals; Atropine; Lethal Dose 50; Mollusca; Muscle Tonus; Neostigmine; Pigmentation; Respiration; S | 1973 |
The cholinergic system, amnesia and memory.
Topics: Amnesia; Animals; Avoidance Learning; Electroshock; Humans; Male; Memory; Neostigmine; Physostigmine | 1972 |