Page last updated: 2024-10-31

neostigmine and Pneumonia

neostigmine has been researched along with Pneumonia in 9 studies

Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.

Pneumonia: Infection of the lung often accompanied by inflammation.

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19903 (33.33)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (44.44)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Liu, H1
Luo, R1
Cao, S1
Zheng, B1
Ye, L1
Zhang, W1
Scheffenbichler, FT1
Rudolph, MI1
Friedrich, S1
Althoff, FC1
Xu, X1
Spicer, AC1
Patrocínio, M1
Ng, PY1
Deng, H1
Anderson, TA1
Eikermann, M1
Cumberworth, A1
Caruso, LJ1
Reed, H1
Zhang, RV1
Bulka, CM1
Terekhov, MA1
Martin, BJ1
Dmochowski, RR1
Hayes, RM1
Ehrenfeld, JM1
Kox, M1
Pompe, JC1
Peters, E1
Vaneker, M1
van der Laak, JW1
van der Hoeven, JG1
Scheffer, GJ1
Hoedemaekers, CW1
Pickkers, P1
WALCOK, F1
DOSTAL, J1
STUART, WD1
Skeggs, DB1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Intraoperative Neuromuscular Blockade on Postoperative Atelectasis in Patients Undergoing Thoracic Surgery With One Lung Ventilation: Moderate vs. Deep Block[NCT03503565]118 participants (Actual)Observational2018-10-11Completed
Combined General and Spinal Anesthesia vs. Combined General and Spinal Anesthesia With Neuromuscular Blockade for Operative Repair of Hip Fractures[NCT03226080]Phase 40 participants (Actual)Interventional2017-07-19Withdrawn (stopped due to Study terminated with IRB on 20Feb2019 due to lack of enrollment.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Atelectasis Area on Chest CT

Atelectasis on Chest CT The lung area was delineated manually. To calculate atelectasis, a region of interest was laid out that encircled the dense part of the lung, excluding large vessels. For further analysis, the lung was divided into four categories: areas with densities ranging from -1000 to -900 Hounsfield units (HU) were classified as over-aerated, from -900 to -500 HU as normally aerated, from -500 to -100 HU as poorly aerated, and from -100 to +100 HU as non-aerated (atelectasis). The proportion of non-aerated lung tissue (-100 to +100 HU) was calculated by dividing the area of the region of interest with the whole lungs. (NCT03503565)
Timeframe: 1 day after the end of surgery

Interventionpercentage of atelectasis volume (Median)
Moderate Block Group1.32
Deep Block Group1.41

Reviews

1 review available for neostigmine and Pneumonia

ArticleYear
Superiority of sugammadex in preventing postoperative pulmonary complications.
    Chinese medical journal, 2023, Jul-05, Volume: 136, Issue:13

    Topics: Humans; Neostigmine; Neuromuscular Blockade; Pneumonia; Postoperative Complications; Respiratory Ins

2023

Other Studies

8 other studies available for neostigmine and Pneumonia

ArticleYear
Effects of high neuromuscular blocking agent dose on post-operative respiratory complications in infants and children.
    Acta anaesthesiologica Scandinavica, 2020, Volume: 64, Issue:2

    Topics: Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Neostigmine; Neuromuscular B

2020
Neuromuscular Blockade and Risk of Postoperative Pneumonia.
    Anesthesiology, 2017, Volume: 127, Issue:1

    Topics: Humans; Neostigmine; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents; Pneumonia; Risk

2017
Risk of Postoperative Pneumonia with Neuromuscular Blockade: Keep It Simple!
    Anesthesiology, 2017, Volume: 127, Issue:1

    Topics: Humans; Neostigmine; Neuromuscular Blockade; Neuromuscular Nondepolarizing Agents; Pneumonia; Risk

2017
Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia.
    Anesthesiology, 2016, Volume: 125, Issue:4

    Topics: Causality; Cholinesterase Inhibitors; Databases, Factual; Female; Humans; Incidence; Male; Middle Ag

2016
Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia.
    Anesthesiology, 2016, Volume: 125, Issue:4

    Topics: Causality; Cholinesterase Inhibitors; Databases, Factual; Female; Humans; Incidence; Male; Middle Ag

2016
Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia.
    Anesthesiology, 2016, Volume: 125, Issue:4

    Topics: Causality; Cholinesterase Inhibitors; Databases, Factual; Female; Humans; Incidence; Male; Middle Ag

2016
Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia.
    Anesthesiology, 2016, Volume: 125, Issue:4

    Topics: Causality; Cholinesterase Inhibitors; Databases, Factual; Female; Humans; Incidence; Male; Middle Ag

2016
α7 nicotinic acetylcholine receptor agonist GTS-21 attenuates ventilator-induced tumour necrosis factor-α production and lung injury.
    British journal of anaesthesia, 2011, Volume: 107, Issue:4

    Topics: Acute Lung Injury; alpha7 Nicotinic Acetylcholine Receptor; Animals; Benzylidene Compounds; Cholines

2011
[ON THE PROBLEM OF ANESTHESIA IN NEWBORN INFANTS WITH ESOPHAGEAL ATRESIA].
    Rozhledy v chirurgii : mesicnik Ceskoslovenske chirurgicke spolecnosti, 1963, Volume: 42

    Topics: Anesthesia; Anesthesia, Endotracheal; Esophageal Atresia; Esophageal Stenosis; Humans; Infant; Infan

1963
THE OTOLARYNGOLOGIC ASPECTS OF MYASTHENIA GRAVIS.
    The Laryngoscope, 1965, Volume: 75

    Topics: Child; Cough; Deglutition Disorders; Edrophonium; Geriatrics; Humans; Myasthenia Gravis; Neostigmine

1965
Complications associated with the radiotherapy of thymic tumours.
    Proceedings of the Royal Society of Medicine, 1973, Volume: 66, Issue:2

    Topics: Adult; Edrophonium; Humans; Influenza, Human; Male; Myasthenia Gravis; Neostigmine; Pericarditis; Pn

1973