neostigmine has been researched along with Muscle Relaxation in 37 studies
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Muscle Relaxation: That phase of a muscle twitch during which a muscle returns to a resting position.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the onset of muscle relaxation using intravenous vecuronium and cisatracurium and assessed the ability of neostigmine to antagonize (reverse) this effect." | 9.08 | The clinical neuromuscular pharmacology of cisatracurium versus vecuronium during outpatient anesthesia. ( Fontenot, JP; Stevens, JB; Walker, SC, 1997) |
| "Pipecuronium bromide is a new steroidal non-depolarizing muscle relaxant currently under investigation." | 5.28 | A dose-response evaluation of pipecuronium bromide in elderly patients under balanced anesthesia. ( Azad, SS; Beach, CA; Goldberg, ME; Larijani, GE; Marr, AT; Seltzer, JL, 1989) |
| "We investigated the onset of muscle relaxation using intravenous vecuronium and cisatracurium and assessed the ability of neostigmine to antagonize (reverse) this effect." | 5.08 | The clinical neuromuscular pharmacology of cisatracurium versus vecuronium during outpatient anesthesia. ( Fontenot, JP; Stevens, JB; Walker, SC, 1997) |
| "1 mM solution of the acetylcholinesterase inhibitor neostigmine into the L7 level of the dorsal horn of anesthetized cats to determine its effects on the mean arterial blood pressure (MAP) and heart rate (HR) responses to static muscle contraction or passive stretch." | 3.70 | Spinal cholinergic inhibition of the pressor response to skeletal muscle activation. ( Hand, GA; Shealy, WD; Treuhaft, BS; Vrettakos, PJ; Wilson, LB, 1999) |
| " The optimal positioning of these thumb pressure sensing (TPS) devices and their sensitivity and accuracy during onset, spontaneous (partial) recovery and pharmacologic reversal of NMB, were determined in anesthetized patients during muscle relaxation (Vecuronium) and reversal (Neostigmine)." | 3.69 | Simple and cost effective clinical methods for measuring neuromuscular fade responses with emphasis on "train of four" fade. ( Gyermek, L, 1997) |
| "08 mg/kg), 36 surgical patients undergoing barbiturate/halothane anesthesia were given edrophonium 0." | 3.67 | [Antagonism of an intubation dose of vecuronium]. ( Baar, H; Lazarus, G; Sold, M, 1987) |
| " The goal of our study was to investigate the real-world practice pattern of dosing of neuromuscular blocking agents (NMBA), utilizing the amount of NMBA used during the course of a case, adjusted for patient weight and case duration, as a surrogate measure of depth of NMB." | 1.51 | Investigation of intraoperative dosing patterns of neuromuscular blocking agents. ( Beutler, SS; Gimlich, R; Palsen, S; Urman, RD; Wu, A; Yang, HK, 2019) |
| "Pipecuronium bromide is a new steroidal non-depolarizing muscle relaxant currently under investigation." | 1.28 | A dose-response evaluation of pipecuronium bromide in elderly patients under balanced anesthesia. ( Azad, SS; Beach, CA; Goldberg, ME; Larijani, GE; Marr, AT; Seltzer, JL, 1989) |
| "Atropine was able to antagonize competitively acetylcholine (pA2 = 9." | 1.27 | Cholinergic transmission in vas deferens. ( Bustos, E; Miranda, H; Paeile, C, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (40.54) | 18.7374 |
| 1990's | 8 (21.62) | 18.2507 |
| 2000's | 4 (10.81) | 29.6817 |
| 2010's | 10 (27.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Marshall, SD | 1 |
| Serpell, J | 1 |
| Murphy, GS | 1 |
| Szokol, JW | 1 |
| Avram, MJ | 1 |
| Greenberg, SB | 1 |
| Shear, TD | 1 |
| Deshur, MA | 1 |
| Benson, J | 1 |
| Newmark, RL | 1 |
| Maher, CE | 1 |
| Abad-Gurumeta, A | 1 |
| Palsen, S | 1 |
| Wu, A | 1 |
| Beutler, SS | 1 |
| Gimlich, R | 1 |
| Yang, HK | 1 |
| Urman, RD | 1 |
| Dubois, PE | 1 |
| Mulier, JP | 1 |
| Yang, Z | 1 |
| Pan, A | 1 |
| Zuo, W | 1 |
| Guo, J | 1 |
| Zhou, W | 1 |
| Debaene, B | 1 |
| Meistelman, C | 1 |
| Plaud, B | 1 |
| Lima, FJ | 1 |
| Brito, TS | 1 |
| Freire, WB | 1 |
| Costa, RC | 1 |
| Linhares, MI | 1 |
| Sousa, FC | 1 |
| Lahlou, S | 1 |
| Leal-Cardoso, JH | 1 |
| Santos, AA | 1 |
| Magalhães, PJ | 1 |
| Cellini, J | 2 |
| DiNovo, K | 1 |
| Harlow, J | 1 |
| LePard, KJ | 2 |
| Zaura Jukic, AM | 1 |
| Senbel, AM | 1 |
| Hashad, A | 1 |
| Sharabi, FM | 1 |
| Daabees, TT | 1 |
| Vasella, FC | 1 |
| Frascarolo, P | 1 |
| Spahn, DR | 1 |
| Magnusson, L | 1 |
| Frizelle, HP | 1 |
| Curran, E | 1 |
| Twomey, C | 1 |
| MacAdoo, J | 1 |
| Shorten, G | 1 |
| Doggrell, SA | 1 |
| Waldron, JB | 1 |
| Bustos, E | 1 |
| Miranda, H | 1 |
| Paeile, C | 1 |
| Burleigh, DE | 1 |
| Levine, DF | 1 |
| Motson, RW | 1 |
| Fukushima, K | 1 |
| Aoki, T | 1 |
| Ishikawa, J | 1 |
| Carlsson, C | 1 |
| Rosén, I | 1 |
| Nilsson, E | 1 |
| Gleed, RD | 1 |
| Jones, RS | 1 |
| Whalley, DG | 1 |
| Lewis, B | 1 |
| Bedocs, NM | 1 |
| Franks, CJ | 1 |
| Holden-Dye, L | 1 |
| Williams, RG | 1 |
| Pang, FY | 1 |
| Walker, RJ | 1 |
| Bjerle, P | 1 |
| Ek, B | 1 |
| Linderholm, H | 1 |
| Steen, L | 1 |
| Davis, L | 1 |
| Jayarajah, MJ | 1 |
| Toner, CC | 1 |
| Flynn, PJ | 1 |
| Gyermek, L | 1 |
| Stevens, JB | 1 |
| Walker, SC | 1 |
| Fontenot, JP | 1 |
| Hand, GA | 1 |
| Vrettakos, PJ | 1 |
| Treuhaft, BS | 1 |
| Shealy, WD | 1 |
| Wilson, LB | 1 |
| Cozanitis, DA | 1 |
| Adams, PR | 1 |
| Miller, RD | 1 |
| Booij, LH | 1 |
| Agoston, S | 1 |
| Crul, JF | 1 |
| Gong, T | 1 |
| Wu, ZY | 1 |
| Iwatsuki, K | 1 |
| Ueda, N | 1 |
| Muteki, T | 1 |
| Tsuda, H | 1 |
| Inoue, S | 1 |
| Nishina, H | 1 |
| Azad, SS | 1 |
| Larijani, GE | 1 |
| Goldberg, ME | 1 |
| Beach, CA | 1 |
| Marr, AT | 1 |
| Seltzer, JL | 1 |
| Tanaka, DT | 1 |
| Grunstein, MM | 1 |
| Altiere, RJ | 1 |
| Szarek, JL | 1 |
| Diamond, L | 1 |
| Sold, M | 1 |
| Lazarus, G | 1 |
| Baar, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Pilot Study of EEG Signs of Awakening Secondary to Injection of Sugammadex: Evaluation by Recording Bispectral Index and NeuroSENSE (Prospective, Double-blind Study)[NCT01161004] | Phase 4 | 50 participants (Actual) | Interventional | 2010-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for neostigmine and Muscle Relaxation
| Article | Year |
|---|---|
A review of the interest of sugammadex for deep neuromuscular blockade management in Belgium.
Topics: Algorithms; Belgium; gamma-Cyclodextrins; Humans; Muscle Relaxation; Neostigmine; Neuromuscular Bloc | 2013 |
[Indications and clinical use of sugammadex].
Topics: Algorithms; Androstanols; Anesthesia Recovery Period; Clinical Trials, Phase III as Topic; Contraind | 2009 |
[Sugammadex: something new to improve patient safety or simply a gadget?].
Topics: Androstanols; Anesthesia Recovery Period; Atracurium; Cost-Benefit Analysis; Drug Approval; Electrod | 2009 |
8 trials available for neostigmine and Muscle Relaxation
| Article | Year |
|---|---|
Failed Vocalis Muscle Monitoring During Thyroid Surgery Resulting From Residual Muscle Relaxation.
Topics: Adjuvants, Anesthesia; Administration, Intravenous; Atracurium; Cholinesterase Inhibitors; Glycopyrr | 2017 |
Neostigmine Administration after Spontaneous Recovery to a Train-of-Four Ratio of 0.9 to 1.0: A Randomized Controlled Trial of the Effect on Neuromuscular and Clinical Recovery.
Topics: Adult; Aged; Anesthesia Recovery Period; Cholinesterase Inhibitors; Double-Blind Method; Female; Hum | 2018 |
Antagonism of neuromuscular blockade but not muscle relaxation affects depth of anaesthesia.
Topics: Adult; Aged; Anesthetics, Combined; Anesthetics, Intravenous; Atracurium; Blood Pressure; Cholineste | 2005 |
Nausea and vomiting after cataract surgery: does neostigmine have an emetic effect?
Topics: Aged; Anesthesia, General; Cataract Extraction; Cholinesterase Inhibitors; Electric Stimulation; Fem | 2005 |
Recovery of neuromuscular function after atracurium and pancuronium maintenance of pancuronium block.
Topics: Adult; Anesthesia Recovery Period; Atracurium; Drug Interactions; Female; Glycopyrrolate; Humans; Ma | 1994 |
Evaluation of neuromuscular effects and antagonism of rocuronium bromide: a preliminary report.
Topics: Adolescent; Adult; Androstanols; Anesthesia; Cholinesterase Inhibitors; Double-Blind Method; Edropho | 1995 |
The clinical neuromuscular pharmacology of cisatracurium versus vecuronium during outpatient anesthesia.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Anesthesia; Atracurium; Dose-Response Relationshi | 1997 |
Is the diagnosis of significant residual neuromuscular blockade improved by using double-burst nerve stimulation?
Topics: Analysis of Variance; Anesthesia, Inhalation; Anesthesia, Intravenous; Electric Stimulation; Female; | 1991 |
26 other studies available for neostigmine and Muscle Relaxation
| Article | Year |
|---|---|
Evidence of residual neuromuscular block with sugammadex vs neostigmine.
Topics: Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Muscle Relaxation; Neostigmine; Neur | 2018 |
Investigation of intraoperative dosing patterns of neuromuscular blocking agents.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Androstanols; Anesthesia, General; Atracurium; Body Mass | 2019 |
Relaxant effect of flavonoid naringenin on contractile activity of rat colonic smooth muscle.
Topics: Animals; Calcium; Cells, Cultured; Colon; Dose-Response Relationship, Drug; Flavanones; Gastrointest | 2014 |
The essential oil of Eucalyptus tereticornis, and its constituents alpha- and beta-pinene, potentiate acetylcholine-induced contractions in isolated rat trachea.
Topics: Acetylcholine; Animals; Atropine; Barium; Bicyclic Monoterpenes; Bridged Bicyclo Compounds; Bronchod | 2010 |
Regional differences in neostigmine-induced contraction and relaxation of stomach from diabetic guinea pig.
Topics: Animals; Autonomic Nervous System Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathies; | 2011 |
Neostigmine-induced contraction and nitric oxide-induced relaxation of isolated ileum from STZ diabetic guinea pigs.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium-Dependent Relaxing Factors; Gastrointestinal M | 2011 |
Activation of muscarinic receptors inhibits neurogenic nitric oxide in the corpus cavernosum.
Topics: Animals; Male; Muscarinic Agonists; Muscle Relaxation; Neostigmine; Nitric Oxide; Parasympathomimeti | 2012 |
The effects of iprindole on noradrenergic transmission in the rat anococcygeus muscle.
Topics: Animals; Electric Stimulation; In Vitro Techniques; Indoles; Iprindole; Male; Muscle Contraction; Mu | 1983 |
Cholinergic transmission in vas deferens.
Topics: Acetylcholine; Animals; Atropine; Electrophysiology; In Vitro Techniques; Male; Muscle Relaxation; M | 1983 |
A method for studying the actions of drugs on motility of vascularly perfused segments of human colon.
Topics: Bethanechol Compounds; Carbon Dioxide; Colon; Electric Stimulation; Gastrointestinal Motility; Gluco | 1984 |
[Antagonistic effects of neostigmine, 4-aminopyridine and 3,4-diaminopyridine on muscle relaxing effects of d-tubocurarine].
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Muscle Contraction; Muscle Relaxation; Neos | 1983 |
Can 4-aminopyridine be used to reverse anaesthesia and muscle relaxation?
Topics: 4-Aminopyridine; Adolescent; Adult; Aminopyridines; Anesthetics; Drug Evaluation; Electrocardiograph | 1983 |
Observations on the neuromuscular blocking action of gallamine and pancuronium and their reversal by neostigmine.
Topics: Animals; Atropine; Dogs; Gallamine Triethiodide; Injections, Intravenous; Muscle Relaxation; Muscles | 1982 |
A nematode FMRFamide-like peptide, SDPNFLRFamide (PF1), relaxes the dorsal muscle strip preparation of Ascaris suum.
Topics: Acetylcholine; Animals; Ascaris suum; Dose-Response Relationship, Drug; Electrophysiology; Female; F | 1994 |
Oesophageal dysfunction in familial amyloidosis with polyneuropathy.
Topics: Adult; Aged; Amyloidosis; Deglutition; Esophageal Diseases; Female; Gastrointestinal Motility; Human | 1993 |
Simple and cost effective clinical methods for measuring neuromuscular fade responses with emphasis on "train of four" fade.
Topics: Anesthesia, General; Cost-Benefit Analysis; Evaluation Studies as Topic; Hand; Humans; Intraoperativ | 1997 |
Spinal cholinergic inhibition of the pressor response to skeletal muscle activation.
Topics: Analysis of Variance; Animals; Atropine; Blood Pressure; Cats; Heart Rate; Microdialysis; Muscle Con | 1999 |
The potency ratio of galanthamine and neostigmine on the reversal of the tubocurarine block in the isolated rat diaphragm.
Topics: Animals; Diaphragm; Dose-Response Relationship, Drug; Female; Galantamine; Muscle Relaxation; Neosti | 1977 |
Relaxation experiments using bath-applied suberyldicholine.
Topics: Animals; Anura; Bungarotoxins; Choline; Dicarboxylic Acids; Dose-Response Relationship, Drug; Electr | 1977 |
4-Aminopyridine potentiates neostigmine and pyridostigmine in man.
Topics: Adult; Aminopyridines; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Heart Rate; Human | 1979 |
[Some pharmacologic actions of the dahurisoline methyl bromide, a preliminary report (author's transl)].
Topics: Alkaloids; Animals; Calcium Gluconate; Cats; Female; Isoquinolines; Male; Mice; Muscle Contraction; | 1979 |
[Current state of the clinical use of muscle relaxants and its future].
Topics: Anesthesia, General; Animals; Atropine; Drug Utilization; Humans; Intubation, Intratracheal; Muscle | 1976 |
A dose-response evaluation of pipecuronium bromide in elderly patients under balanced anesthesia.
Topics: Aged; Androstane-3,17-diol; Androstanols; Anesthesia; Dose-Response Relationship, Drug; Female; Huma | 1989 |
Vasoactive effects of substance P on isolated rabbit pulmonary artery.
Topics: Animals; Atropine; Biomechanical Phenomena; Chlorpheniramine; Cimetidine; Dose-Response Relationship | 1985 |
Neurally mediated nonadrenergic relaxation in cat airways occurs independent of cholinergic mechanisms.
Topics: Acetylcholine; Animals; Atropine; Bethanechol; Bethanechol Compounds; Bronchi; Cats; Electric Stimul | 1985 |
[Antagonism of an intubation dose of vecuronium].
Topics: Anesthesia; Edrophonium; Halothane; Humans; Intubation; Muscle Contraction; Muscle Relaxation; Neost | 1987 |