neostigmine has been researched along with Muscle Contraction in 435 studies
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We investigated the onset of muscle relaxation using intravenous vecuronium and cisatracurium and assessed the ability of neostigmine to antagonize (reverse) this effect." | 9.08 | The clinical neuromuscular pharmacology of cisatracurium versus vecuronium during outpatient anesthesia. ( Fontenot, JP; Stevens, JB; Walker, SC, 1997) |
| "To examine the effects of discontinuing sevoflurane or isoflurane anesthesia (1 minimum alveolar anesthetic concentration [MAC] of end-tidal concentrations, together with 66% N2O/O2) on the reversal of vecuronium-induced neuromuscular blockade (an initial dose = 100 micrograms/kg), the electromyographic response of the abductor digiti minimi was monitored at 20-s intervals after train-of-four (TOF) stimulation of the ulnar nerve in 192 ASA grades I and II patients." | 7.69 | Inadequate antagonism of vecuronium-induced neuromuscular block by neostigmine during sevoflurane or isoflurane anesthesia. ( Fujita, T; Morita, T; Saito, S; Sato, H; Sugaya, T; Tsukagoshi, H, 1995) |
| "Acute respiratory and metabolic acidosis as well as metabolic alkalosis increased (by 11, 11, 21%) whereas respiratory alkalosis antagonized (by 10%) the partial steady state block produced by pipecuronium infusion on the anterior tibialis muscle of the cat." | 7.67 | Effects of respiratory and metabolic alkalosis and acidosis on pipecuronium neuromuscular block. ( Biró, K, 1988) |
| "Pipecuronium bromide is a new steroidal non-depolarizing muscle relaxant currently under investigation." | 5.28 | A dose-response evaluation of pipecuronium bromide in elderly patients under balanced anesthesia. ( Azad, SS; Beach, CA; Goldberg, ME; Larijani, GE; Marr, AT; Seltzer, JL, 1989) |
| "We investigated the onset of muscle relaxation using intravenous vecuronium and cisatracurium and assessed the ability of neostigmine to antagonize (reverse) this effect." | 5.08 | The clinical neuromuscular pharmacology of cisatracurium versus vecuronium during outpatient anesthesia. ( Fontenot, JP; Stevens, JB; Walker, SC, 1997) |
| " Neostigmine and calcium antagonized the neuromuscular blockade caused by gentamicin, but augmented that caused by clindamycin." | 3.74 | Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations. ( Lee, JH; Lee, JM; Lee, SC; Lee, SI, 2008) |
| "Neostigmine causes airway smooth muscle contraction through the direct stimulation of muscarinic receptors and the activation of phosphatidylinositol (PI) responses." | 3.72 | Effects of ketamine on neostigmine-induced contractile and phosphatidylinositol responses of the rat trachea. ( Makita, T; Miyoshi, H; Saito, M; Shibata, O; Sumikawa, K; Yamaguchi, M, 2003) |
| "1 mM solution of the acetylcholinesterase inhibitor neostigmine into the L7 level of the dorsal horn of anesthetized cats to determine its effects on the mean arterial blood pressure (MAP) and heart rate (HR) responses to static muscle contraction or passive stretch." | 3.70 | Spinal cholinergic inhibition of the pressor response to skeletal muscle activation. ( Hand, GA; Shealy, WD; Treuhaft, BS; Vrettakos, PJ; Wilson, LB, 1999) |
| " Immunized BP2 mice developed an acute bronchoconstriction in vivo and airway muscle contraction in vitro in response to ovalbumin (OA) and these contractions were dose dependent." | 3.70 | Anaphylactic bronchoconstriction in BP2 mice: interactions between serotonin and acetylcholine. ( Brink, C; Eum, SY; Labat, C; Lefort, J; Norel, X; Vargaftig, BB, 1999) |
| "To investigate the relationship between total body weight (TBW) or body mass index (BMI) and atracurium reversal time." | 3.70 | Antagonism of atracurium-induced block in obese patients. ( Kirkegaard-Nielsen, H; Lindholm, P; Petersen, HS; Severinsen, IK, 1998) |
| "To examine the effects of discontinuing sevoflurane or isoflurane anesthesia (1 minimum alveolar anesthetic concentration [MAC] of end-tidal concentrations, together with 66% N2O/O2) on the reversal of vecuronium-induced neuromuscular blockade (an initial dose = 100 micrograms/kg), the electromyographic response of the abductor digiti minimi was monitored at 20-s intervals after train-of-four (TOF) stimulation of the ulnar nerve in 192 ASA grades I and II patients." | 3.69 | Inadequate antagonism of vecuronium-induced neuromuscular block by neostigmine during sevoflurane or isoflurane anesthesia. ( Fujita, T; Morita, T; Saito, S; Sato, H; Sugaya, T; Tsukagoshi, H, 1995) |
| " Non-contractile Ca2+ mobilization (unaccompanied by muscle contraction) was initiated by nerve stimulation in the presence of neostigmine (more than 0." | 3.69 | Postsynaptic nicotinic receptor desensitized by non-contractile Ca2+ mobilization via protein kinase-C activation at the mouse neuromuscular junction. ( Dezaki, K; Kimura, I; Kimura, M; Tsuneki, H, 1995) |
| " Simultaneous measurement of gastrocnemius muscle contraction and efferent phrenic nerve activity was used to determine the primary cause of respiratory failure produced by neostigmine and diisopropyl fluorophosphate (DFP) in anesthetized cats." | 3.68 | Mechanisms of respiratory failure produced by neostigmine and diisopropyl fluorophosphate. ( Dretchen, KL; Fleming, NW; Henderson, TR, 1991) |
| "The antagonisms to the d-tubocurarine-induced neuromuscular blockade by neostigmine and 3,4-diaminopyridine (DAP) were studied quantitatively in the isolated phrenic nerve-diaphragm preparation of mice in vitro and in lethality of mice in vivo by assaying concentrations of d-tubocurarine needed to produce 70% block of indirect muscle contraction and LD50, respectively." | 3.67 | Potentiation between neostigmine and 3,4-diaminopyridine in antagonizing the neuromuscular block induced by D-tubocurarine. ( Chang, CC; Hong, SJ; Lin, HL; Shieh, BH; Su, MJ, 1984) |
| "We investigated the effects of aminophylline, isoproterenol, and neostigmine on decreased diaphragmatic contractility induced by hypercapnia." | 3.67 | Effects of aminophylline, isoproterenol, and neostigmine on hypercapnic depression of diaphragmatic contractility. ( Fitzgerald, RS; Howell, S; Roussos, C, 1985) |
| "Acute respiratory and metabolic acidosis as well as metabolic alkalosis increased (by 11, 11, 21%) whereas respiratory alkalosis antagonized (by 10%) the partial steady state block produced by pipecuronium infusion on the anterior tibialis muscle of the cat." | 3.67 | Effects of respiratory and metabolic alkalosis and acidosis on pipecuronium neuromuscular block. ( Biró, K, 1988) |
| "08 mg/kg), 36 surgical patients undergoing barbiturate/halothane anesthesia were given edrophonium 0." | 3.67 | [Antagonism of an intubation dose of vecuronium]. ( Baar, H; Lazarus, G; Sold, M, 1987) |
| " Electrophysiological and pharmacological changes typical of myasthenia gravis were recorded, including decremental responses to repetitive stimuli, curare sensitivity, neostigmine reversal, and posttetanic phenomena." | 3.65 | Blockade of acetylcholine receptors: a model of myasthenia gravis. ( Drachman, DB; Satyamurti, S; Slone, F, 1975) |
| "A close correlation has been shown to exist between the in vitro anticholinesterase potencies of ambenonium, neostigmine, methoxyambenonium and edrophonium chloride and their abilities to increase muscle contractions produced by close-arterial injections of acetylcholine." | 3.64 | Facilitation of neuromuscular transmission by anticholinesterase drugs. ( BLABER, LC, 1963) |
| "When edrophonium was used, no cases of recurarization were observed." | 2.84 | Effects of neostigmine or edrophonium on force of contraction when administered at a train-of-four ratio of 0.9 in anesthetized dogs. ( Campoy, L; Gleed, RD; Martin-Flores, M; Romano, M; Sakai, DM; Tseng, CT, 2017) |
| "Neostigmine has a similar, although longer, effect." | 2.69 | Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium. ( Brown, R; Fisher, DM; Fogarty, D; Kirkegaard-Nielsen, H; Sharma, ML; Szenohradszky, J, 2000) |
| "Cisatracurium is a new nondepolarizing muscle relaxant." | 2.68 | A comparison of cisatracurium and atracurium: onset of neuromuscular block after bolus injection and recovery after subsequent infusion. ( Buzello, W; Diefenbach, C; Mellinghoff, H; Radbruch, L, 1996) |
| "Mivacurium infusion was titrated to give a 90% block of first twitch height." | 2.68 | Recovery from mivacurium block with or without anticholinesterase following continuous infusion in obstetric patients. ( Chan, AM; Hui, TW; Jan, GS; Lo, JW; Tong, WN, 1996) |
| "Seventeen patients with end stage chronic renal failure and 18 patients with normal renal function were anaesthetized with 0." | 2.67 | Neuromuscular block with doxacurium (BW A938U) in patients with normal or absent renal function. ( Cashman, JN; Jones, RM; Luke, JJ, 1990) |
| "The dose-response curves for neostigmine- and edrophonium-assisted antagonism of rocuronium bromide neuromuscular blockade for the single twitch and TOF ratio were not parallel." | 2.67 | Dose-response relationships for edrophonium and neostigmine antagonism of rocuronium bromide (ORG 9426)-induced neuromuscular blockade. ( Abdulatif, M; al-Ghamdi, A; Naguib, M, 1993) |
| "We have studied the dose-response relationships for neostigmine and edrophonium during antagonism of neuromuscular block induced by mivacurium chloride." | 2.67 | Dose-response relationships for edrophonium and neostigmine antagonism of mivacurium-induced neuromuscular block. ( Abdulatif, M; al-Ghamdi, A; Hamo, I; Naguib, M; Nouheid, R, 1993) |
| "To determine the potencies of neostigmine, pyridostigmine, and edrophonium in reversing pancuronium and d-tubocurarine blockade, dose-response curves were established for first twitch height recovery and train-of-four ratio." | 2.66 | Dose-response curves for edrophonium, neostigmine, and pyridostigmine after pancuronium and d-tubocurarine. ( Antzaka, C; Bevan, DR; Donati, F; McCarroll, SM; McCready, D, 1987) |
| "The dose-response curves of vecuronium and pancuronium were compared during ketamine anaesthesia in 60 patients (ASA I)." | 2.65 | Dose-response relationships and neuromuscular blocking effects of vecuronium pancuronium during ketamine anaesthesia. ( Engbaek, J; Ording, H; Pedersen, T; Viby-Mogensen, J, 1984) |
| "Pancuronium 3 mg/70 kg was antagonized with neostigmine 2." | 2.65 | Impaired neostigmine antagonism of pancuronium during enflurane anaesthesia in man. ( Bevan, DR; Delisle, S, 1982) |
| "Ethosuximide is a drug used for the treatment of absence seizures." | 1.33 | Neostigmine, but not metoclopramide, abolishes ethosuximide-induced functional gastrointestinal disturbances. ( Kostadinova, I; Krastev, A; Sirakov, V; Turiiski, V, 2005) |
| "(3) Tetrodotoxin (TTX) was tested on the anti-ChE drugs-induced responses." | 1.30 | Contractile and phosphatidylinositol responses of rat trachea to anticholinesterase drugs. ( Hara, T; Iwanaga, S; Makita, T; Shibata, O; Shibata, S; Sumikawa, K; Tsuda, A, 1998) |
| "Neostigmine was administered at either 10% recovery of the twitch height (TH10) at the adductor pollicis muscle (n = 14) or upon reappearance of the first response at the orbicularis oculi muscle (OO1) after train-of-four (TOF) stimulation (n = 16), the latter representing a deeper degree of neuromuscular blockade." | 1.29 | Effect of neostigmine at different levels of mivacurium-induced neuromuscular blockade. ( Baras, E; Camatte, S; Chandon, M; Just, B; Lienhart, A; Trévien, V, 1995) |
| " A pharmacodynamic model was developed by considering acetylcholinesterase (AChE) inhibition, direct antagonism to the nicotinic receptor, and desensitization of the nicotinic receptor." | 1.29 | Pharmacodynamic analysis of contractile potentiation by cholinesterase inhibitors in rats. ( Iga, T; Sawada, Y; Yamamoto, K, 1996) |
| "Mivacurium was infused in five patients to maintain 90% depression of adductor pollicis twitch tension, then 50 micrograms/kg intravenous neostigmine was administered without altering the mivacurium infusion." | 1.29 | The effect of neostigmine on twitch tension and muscle relaxant concentration during infusion of mivacurium or vecuronium. ( Brown, R; Fisher, DM; Lau, M; Sharma, ML; Szenohradszky, J, 1995) |
| "Neostigmine produced an increase in TOF ratio in 52 patients and a decrease in 8." | 1.29 | Reversal of residual neuromuscular block with neostigmine at one to four hours after a single intubating dose of vecuronium. ( Caldwell, JE, 1995) |
| " These results indicate that prolonged paralysis after long-term administration of high-dose pancuronium is caused primarily by failure of neuromuscular transmission, most likely caused by the persistent plasma concentrations of the drug in the pharmacologically active range." | 1.29 | Prolonged paralysis after long-term, high-dose infusion of pancuronium in anaesthetized cats. ( Agoston, S; den Hertog, A; Henning, RH; Houwertjes, MC; Scaf, AH, 1993) |
| " Cumulative dose-response showed the ED95 to be 33." | 1.28 | Clinical evaluation of doxacurium chloride. ( Clarke, RS; Cooper, R; Maddineni, VR; Mirakhur, RK; Stanley, JC, 1992) |
| "Mivacurium 0." | 1.28 | Influence of plasma cholinesterase activity on recovery from mivacurium-induced neuromuscular blockade in phenotypically normal patients. ( Jensen, E; Jensen, FS; Ostergaard, D; Skovgaard, LT; Viby-Mogensen, J, 1992) |
| "Pretreatment with formamide (2 M for 30 min) abolished contractile Ca2+ transients, but did not affect non-contractile ones." | 1.28 | Reversed effect of caffeine on non-contractile and contractile Ca2+ mobilization operated by acetylcholine receptor in mouse diaphragm muscle. ( Kimura, I; Kimura, M; Kondoh, T; Tsuneki, H, 1991) |
| "Pipecuronium bromide is a new steroidal non-depolarizing muscle relaxant currently under investigation." | 1.28 | A dose-response evaluation of pipecuronium bromide in elderly patients under balanced anesthesia. ( Azad, SS; Beach, CA; Goldberg, ME; Larijani, GE; Marr, AT; Seltzer, JL, 1989) |
| "Atropine was more effective at high frequencies of stimulation (greater than or equal to 30 Hz), and alpha, beta-methylene ATP at low frequencies (less than or equal to 15 Hz)." | 1.28 | Electrical and mechanical responses of guinea-pig bladder muscle to nerve stimulation. ( Brading, AF; Mostwin, JL, 1989) |
| "Thus loxiglumide acts as a specific antagonist of the actions of CCK on small intestinal motor activity in the dog." | 1.28 | Effects of CCK receptor blockade on intestinal motor activity in conscious dogs. ( Karaus, M; Niederau, C, 1991) |
| "Pretreatment with atropine or TTX reduced base-line tension in some TSM samples, whereas neostigmine invariably caused contraction of TSM." | 1.27 | Mechanisms of histamine-induced contraction of canine airway smooth muscle. ( Irvin, CG; Martin, JG; Shenkier, T; Shore, S, 1983) |
| " Denervation changes in the muscle were evaluated using the resting membrane potential and dose-response curves obtained by plotting acetylcholine-induced contractures." | 1.27 | Effect of protein synthesis inhibitors on the trophic action of the nerve stump. ( Higashimori, E; Komatsu, K; Satoh, S; Uchida, K, 1983) |
| "Droperidol caused no increase in twitch, but it depressed the twitch by 50% at concentrations of 9." | 1.27 | Myoneural effects of pethidine and droperidol. ( Boros, M; Chaudhry, IA; Duncalf, RM; Foldes, FF; Nagashima, H; Sherman, EH, 1984) |
| "Atropine pretreatment alone significantly delayed transit while hexamethonium treatment alone did not affect intestinal transit." | 1.27 | Cholinergic neurons mediate intestinal propulsion in the rat. ( Burks, TF; Galligan, JJ, 1986) |
| " A sigmoid dose-response curve was obtained for the phasic contraction." | 1.27 | Effect of sodium propionate on the contractile response of the rat ileum in situ. ( Yajima, T, 1984) |
| " With reduced dosage and with careful neuromuscular monitoring, vecuronium can be used safely in the myasthenic patient." | 1.27 | Vecuronium in the myasthenic patient. ( Bell, CF; Florence, AM; Hunter, JM; Jones, RS; Utting, JE, 1985) |
| "Pretreatment with neostigmine or collagenase partially antagonized the initial effects without affecting the steady state effects of DMAE, indicating that the initial effects of DMAE may be, at least in part, due to inhibition of the enzyme acetylcholinesterase." | 1.27 | Endplate channel actions of a hemicholinium-3 analog, DMAE. ( Alkadhi, KA, 1986) |
| " It was concluded that glycopyrrolate enhanced atracurium-induced neuromuscular blockade in the rat diaphragm preparation, and that this effect should be noted when dosing glycopyrrolate in man." | 1.27 | Glycopyrrolate intensifies neuromuscular blockade produced by atracurium in the rat diaphragm preparation. ( Altinel, A; Dark, CH; Jones, CJ; Wali, FA, 1987) |
| " Joint application of ACh and CCh generated a dose-response profile consistent with a model of competitive antagonism between a full agonist (CCh) and a partial one (ACh)." | 1.27 | A study of the contractile response to acetylcholine in human ileal and detrusor muscle: origin of the low efficacy of acetylcholine. ( Cohen, S; Nissenkorn, I; Rubinstein, R, 1986) |
| "Edrophonium was more potent than neostigmine in reversing the combined neuromuscular blockade produced by the muscle relaxants with and without verapamil." | 1.27 | Interaction of verapamil with gallamine and pancuronium and reversal of combined neuromuscular blockade with neostigmine and edrophonium. ( Wali, FA, 1986) |
| "Atracurium was given to 26 patients who had no renal function; in 21 of these neuromuscular block was monitored using the train-of-four stimuli." | 1.26 | Use of atracurium in patients with no renal function. ( Hunter, JM; Jones, RS; Utting, JE, 1982) |
| " Comparison of the results with those from 15 patients given suxamethonium 50 mg showed that atracurium in this dosage took longer to produce complete ablation of the twitch responses but that it lasted longer (about 40 min)." | 1.26 | Use of atracurium during general surgery monitored by the train-of-four stimuli. ( Hunter, JM; Jones, RS; Utting, JE, 1982) |
| "125 mg/kg, however, the dose-response curve was not parallel to those for neostigmine or pyridostigmine." | 1.26 | Edrophonium: duration of action and atropine requirement in humans during halothane anesthesia. ( Cronnelly, R; Miller, RD; Morris, RB, 1982) |
| " The dose-response curves of the frequency for acetylcholine were shifted to the right by atropine and to the left by neostigmine in both preparations." | 1.26 | Effects of acetylcholine on the tone and miniature contractions of isolated dog urinary bladder. ( Ikegami, K; Mutoh, S; Sakanashi, M; Ueda, S; Yano, S, 1982) |
| "In neostigmine-pretreated animals, however, doses between 12." | 1.26 | Corticosteroids and neuromuscular transmission: electrophysiological investigation of the effects of prednisolone on normal and anticholinesterase-treated neuromuscular junction. ( Birnberger, KL; Dengler, R; Rüdel, R; Warelas, J, 1979) |
| " In order to test such a hypothesis fibrillation has been induced in normally innervated muscles by chronic administration of neostigmine and the response of satellite cells has been observed with a scanning electron microscope." | 1.26 | Activation of satellite cells induced by chronic neostigmine administration in the rat. ( Anastasi, G; Denaro, MG; Falzea, G; La Spada, G; Magaudda, L; Salleo, A, 1979) |
| "1 The tetanic and single twitch responses to the adductor pollicis muscle were used to study the neuromuscular effects of repeated dosage of decamethonium in nine anaesthetized patients." | 1.26 | Tachyphylaxis after repeated dosage of decamethonium in anaesthetized man. ( Al-Azawi, S; Hughes, R; Payne, JP, 1982) |
| "Edrophonium was about 12 times less potent than neostigmine in antagonizing Org NC 45." | 1.26 | Some actions of Org NC 45 and of edrophonium in the anaesthetized cat and in man. ( Baird, WL; Bowman, WC; Kerr, WJ, 1982) |
| " For the use of the equation, the parallel shift of the dose-response curve and the unchanged maximum response are prerequisites." | 1.26 | An extension of pA principle to the potentiation of drug effects, and its application to the biological assay of some anticholinesterases and cardenolides. ( Ichikawa, T; Ishikawa, N; Shigei, T; Tsuru, H, 1980) |
| " Dose-response studies indicate that the spasmogenic effect of 0." | 1.26 | Morphine: a dual effect at the canine choledochoduodenal junction. ( Johnson, EE, 1981) |
| "With neostigmine, reversal was hastened and a full recovery with restitution of prerelaxant twitch and disappearance of fades was reached in about 20 min." | 1.26 | Neuromuscular blocking properties of dioxonium. ( Salmenperä, M; Tammisto, T, 1980) |
| "d-Tubocurarine (dTc) was infused intravenously into 35 cats anesthetized with chloralose and urethane at a constant continuous rate to produce and maintain 90 per cent depression of twitch height of the anterior tibial muscle following supramaximal stimulation of the peroneal nerve." | 1.25 | The effect of acid-base balance on neostigmine antagonism of d-tubocurarine-induced neuromuscular blockade. ( Eger, EI; Miller, RD; Van Nyhuis, LS; Way, WL, 1975) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 317 (72.87) | 18.7374 |
| 1990's | 76 (17.47) | 18.2507 |
| 2000's | 22 (5.06) | 29.6817 |
| 2010's | 18 (4.14) | 24.3611 |
| 2020's | 2 (0.46) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, W | 1 |
| Makwana, R | 1 |
| Straface, M | 1 |
| Gharibans, A | 1 |
| Andrews, PLR | 1 |
| Sanger, GJ | 1 |
| Tribuiani, N | 1 |
| de Souza, J | 1 |
| de Queiroz Junior, MA | 1 |
| Baldo, DA | 1 |
| de Campos Orsi, V | 1 |
| Oshima-Franco, Y | 1 |
| Romano, M | 1 |
| Martin-Flores, M | 1 |
| Sakai, DM | 1 |
| Tseng, CT | 1 |
| Campoy, L | 1 |
| Gleed, RD | 1 |
| Bhetwal, BP | 1 |
| Sanders, KM | 2 |
| An, C | 1 |
| Trappanese, DM | 1 |
| Moreland, RS | 1 |
| Perrino, BA | 1 |
| Qu, Z | 1 |
| Zhang, J | 1 |
| Gao, W | 1 |
| Guo, H | 1 |
| Liu, C | 1 |
| Mustafa, S | 1 |
| Ismael, HN | 1 |
| Tack, J | 2 |
| Deloose, E | 1 |
| Ang, D | 1 |
| Scarpellini, E | 1 |
| Vanuytsel, T | 1 |
| Van Oudenhove, L | 1 |
| Depoortere, I | 1 |
| Ito, K | 1 |
| Kawachi, M | 1 |
| Matsunaga, Y | 1 |
| Hori, Y | 1 |
| Ozaki, T | 1 |
| Nagahama, K | 1 |
| Hirayama, M | 1 |
| Kawabata, Y | 1 |
| Shiraishi, Y | 1 |
| Takei, M | 1 |
| Tanaka, T | 1 |
| Chen, JH | 1 |
| Yang, Z | 1 |
| Yu, Y | 1 |
| Huizinga, JD | 2 |
| Ren, Y | 1 |
| Zhu, Y | 1 |
| Liu, L | 1 |
| Yu, T | 1 |
| Dong, X | 1 |
| Berkó, S | 1 |
| Szűcs, KF | 1 |
| Balázs, B | 1 |
| Csányi, E | 1 |
| Varju, G | 1 |
| Sztojkov-Ivanov, A | 1 |
| Budai-Szűcs, M | 1 |
| Bóta, J | 1 |
| Gáspár, R | 1 |
| Desmedt, JE | 2 |
| MOSS, HK | 1 |
| HERRMANN, LG | 1 |
| Lee, SI | 1 |
| Lee, JH | 2 |
| Lee, SC | 1 |
| Lee, JM | 1 |
| Cuprian-Beltechi, AM | 2 |
| Solanki, P | 3 |
| Teramoto, N | 1 |
| Cunnane, TC | 3 |
| Tanaka, C | 1 |
| Domae, K | 1 |
| Hashitani, H | 1 |
| Suzuki, H | 1 |
| El-Moursy, SA | 1 |
| Shawky, HM | 1 |
| Abdel Wahab, Z | 1 |
| Rashed, L | 1 |
| Américo, MF | 1 |
| Oliveira, RB | 1 |
| Corá, LA | 1 |
| Marques, RG | 1 |
| Romeiro, FG | 1 |
| Andreis, U | 1 |
| Miranda, JR | 1 |
| Anuvarbekova, A | 1 |
| Fincan, GS | 1 |
| Vural, IM | 1 |
| Ozger, SI | 1 |
| Ercan, ZS | 1 |
| Utkan, T | 1 |
| Sarioglu, Y | 1 |
| Baso, AC | 1 |
| Serra, CS | 1 |
| Oliveira, AC | 1 |
| Shimizu, N | 1 |
| Nakahara, T | 2 |
| Kubota, Y | 2 |
| Sakamoto, K | 2 |
| Ishii, K | 2 |
| Herbstreit, F | 1 |
| Zigrahn, D | 1 |
| Ochterbeck, C | 1 |
| Peters, J | 1 |
| Eikermann, M | 1 |
| Cellini, J | 2 |
| DiNovo, K | 1 |
| Harlow, J | 1 |
| LePard, KJ | 2 |
| Zhang, RX | 1 |
| Wang, XY | 1 |
| Chen, D | 1 |
| Zaura Jukic, AM | 1 |
| Renjifo, C | 1 |
| Smith, EN | 1 |
| Hodgson, WC | 3 |
| Renjifo, JM | 1 |
| Sanchez, A | 1 |
| Acosta, R | 1 |
| Maldonado, JH | 1 |
| Riveros, A | 1 |
| de Godoy, MA | 1 |
| Accorsi-Mendonça, D | 1 |
| de Oliveira, AM | 1 |
| Ingvast-Larsson, JC | 1 |
| Axén, VC | 1 |
| Kiessling, AK | 1 |
| Saito, M | 2 |
| Shibata, O | 4 |
| Yamaguchi, M | 2 |
| Miyoshi, H | 1 |
| Makita, T | 3 |
| Sumikawa, K | 4 |
| BLABER, LC | 2 |
| CARLYLE, RF | 1 |
| WEBB, GD | 1 |
| WANGEL, AG | 3 |
| DELLER, DJ | 3 |
| VANOV, S | 1 |
| BURN, JH | 1 |
| NG, KK | 1 |
| Yoshimura, M | 1 |
| Gharzouli, K | 1 |
| Holzer, P | 1 |
| Lumsden, NG | 2 |
| Fry, BG | 1 |
| Manjunatha Kini, R | 1 |
| Corsetti, M | 1 |
| Gevers, AM | 1 |
| Caenepeel, P | 1 |
| Mokrý, J | 1 |
| Jakubesová, M | 1 |
| Svihra, J | 1 |
| Urdzik, J | 1 |
| Hudec, M | 1 |
| Nosálová, G | 1 |
| Kliment, J | 1 |
| Bharucha, AE | 1 |
| Dhamija, S | 1 |
| Japp, A | 1 |
| Seide, B | 1 |
| Walters, B | 1 |
| Stroetz, R | 1 |
| Zinsmeister, AR | 1 |
| Hubmayr, RD | 1 |
| Forrest, AS | 1 |
| Ordög, T | 1 |
| Cuprian, AM | 1 |
| Jackson, MV | 1 |
| Sirakov, V | 1 |
| Krastev, A | 1 |
| Kostadinova, I | 1 |
| Turiiski, V | 1 |
| Banerjee, Y | 1 |
| Kini, RM | 1 |
| Kuruppu, S | 1 |
| Vera, CL | 1 |
| Luco, JV | 1 |
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| Diemer, KF | 1 |
| Simhan, K | 1 |
| Lutzeyer, K | 1 |
| Lutzeyer, W | 1 |
| Grundmann, M | 1 |
| Herberová, M | 1 |
| Mathew, BP | 1 |
| Galindo, A | 1 |
| Kennedy, R | 1 |
| Triantaphyllidis, C | 1 |
| Fidani, V | 1 |
| McKlveen, JR | 1 |
| Sokoll, MD | 1 |
| Gergis, SD | 1 |
| Magleby, KL | 1 |
| Stevens, CF | 1 |
| Etessami, S | 1 |
| Geh, SL | 1 |
| Chan, KE | 1 |
| Turner, P | 1 |
| Variava, DM | 1 |
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| Wittkemper, C | 1 |
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| Gillespie, JS | 1 |
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| Gray, GW | 1 |
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| Wienbeck, M | 1 |
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| Weisbrodt, NW | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Role of Induced Phase 3 Contractions in the Control of Hunger and Food Intake[NCT02633579] | 28 participants (Actual) | Interventional | 2012-10-31 | Completed | |||
| Role of Sugammadex as Reversal Agent in Patients Extubated Immediately After Isolated Coronary Artery Bypass Grafting Surgery[NCT03939923] | Phase 4 | 84 participants (Actual) | Interventional | 2019-05-01 | Completed | ||
| Electromyographic Activity of the Diaphragm and of the Rectus Abdominis and Intercostal Muscles During Neostigmine, Sugammadex, or Neostigmine-sugammadex Enhanced Recovery After Neuromuscular Blockade With Rocuronium. A Randomised Controlled Study in Heal[NCT02403063] | Phase 4 | 18 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
| Effects of Postoperative Residual Paralysis on Costs of Hospital Care, Length of Hospitalization and Intensive Care Unit Admission Rate[NCT01718860] | 3,000 participants (Anticipated) | Observational | 2011-04-30 | Active, not recruiting | |||
| INVIBO: Evaluation of the Feasibility and Tolerance of an Intubation Procedure Performed by Means of the Bonfils Fiberscope in Awake Patients With Predicted Difficult Intubation in the Context of ENT Cancer Surgery[NCT01070537] | Phase 2 | 41 participants (Actual) | Interventional | 2008-02-29 | Completed | ||
| Effect of Deep Curarisation and Reversal With Sugammadex on Surgical Conditions and Perioperative Morbidity in Patients Undergoing Laparoscopic Gastric Bypass Surgery[NCT01748643] | Phase 4 | 60 participants (Actual) | Interventional | 2013-04-30 | Completed | ||
| A Multi-center, Randomized, Parallel-group, Comparative, Active-controlled, Safety-assessor Blinded Trial in Adult Subjects Comparing the Efficacy and Safety of Sugammadex (SCH 900616, ORG 25969) Administered at 1-2 PTC With Neostigmine Administered at Re[NCT00724932] | Phase 3 | 140 participants (Actual) | Interventional | 2008-07-16 | Completed | ||
| Can we Antagonize Mivacurium With Neostigmine[NCT03019835] | 80 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| Effect of Intravenous Infusion of Magnesium Sulfate Associated or Not to Lidocaine On the Neuromuscular Blockade Induced by Muscle Relaxant Cistracurium[NCT02483611] | Phase 4 | 48 participants (Actual) | Interventional | 2015-07-31 | Completed | ||
| The Effect of Sugammadex Versus Neostigmine During Neuromuscular Blockade Reversal in Outpatient Surgeries - An Evaluation of Clinical and Associated Health Care Cost[NCT03579589] | Phase 1 | 40 participants (Actual) | Interventional | 2018-08-15 | Completed | ||
| Comparison of Mechanomyographic 100 Versus 200 Hz 5 Second Tetanic Fade Ratios During Neuromuscular Block Recovery[NCT05474638] | 20 participants (Actual) | Interventional | 2022-10-25 | Completed | |||
| Comparison of Two Different Anesthetic Techniques on Incidence of Postoperative Delirium in Cancer Patients After Laparoscopic Surgery in Trendelenburg Position: A Prospective Randomized Clinical Trial[NCT03572517] | 65 participants (Actual) | Interventional | 2017-09-01 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Blood pressure; measure of systolic blood pressure of subject is obtained post-reversal prior to extubation of trachea (NCT03939923)
Timeframe: 0 minutes to 2 hours after study drug administration
| Intervention | mmHg (Mean) |
|---|---|
| Neostigmine/Glycopyrrolate | 105.6 |
| Sugammadex | 112.1 |
Heart rate post-reversal prior to extubation (NCT03939923)
Timeframe: 0 minutes to 2 hours after study drug administration
| Intervention | beats per minute (Mean) |
|---|---|
| Neostigmine/Glycopyrrolate | 81.5385 |
| Sugammadex | 81.1622 |
Peak flow rate - measured by peak flow meter post-extubation at 30-60 mins (NCT03939923)
Timeframe: 30-60 minutes post-extubation
| Intervention | L/min (Mean) |
|---|---|
| Neostigmine/Glycopyrrolate | 1.4609 |
| Sugammadex | 1.416 |
Tidal volume post-reversal prior to extubation (NCT03939923)
Timeframe: between 30 minutes to 1 hour after extubation
| Intervention | Liters (Mean) |
|---|---|
| Neostigmine/Glycopyrrolate | 1.16 |
| Sugammadex | 1.0975 |
"Time to extubation: West Virginia University Hospitals use an electronic medical record (EMR) to chart procedure stop. The definition for time to extubation is from the time the investigators chart procedure stop to the time of extubation." (NCT03939923)
Timeframe: 0 minutes of study drug to 3 days after study drug administration
| Intervention | Minutes (Mean) |
|---|---|
| Neostigmine/Glycopyrrolate | 10.4 |
| Sugammadex | 6 |
Measured from the time of first skin incision to completion of skin closure. (NCT01748643)
Timeframe: Participants will be followed for the duration of the laparoscopic gastric bypass surgery, an expected average of 1.5h
| Intervention | minutes (Mean) |
|---|---|
| Deep Neuromuscular Blockade, Reversal With Sugammadex | 61.3 |
| Normal Neuromuscular Blockade, Reversal With Neostigmine | 70.6 |
Forced expiratory volume in 1 second is measured with the Vitalograph® electronic portable peak flow meter. A mean of 3 measurements in the upright posture in bed before and after surgery will be used. (NCT01748643)
Timeframe: Measured the day before surgery and 30min after completion of surgery (when the modified observer's assessment of alertness/sedation scale is 5 (Patient responds readily to name spoken in normal tone))
| Intervention | percent change from baseline (Mean) |
|---|---|
| Deep Neuromuscular Blockade, Reversal With Sugammadex | 45.2 |
| Normal Neuromuscular Blockade, Reversal With Neostigmine | 48.8 |
Forced vital capacity is measured with the Vitalograph® electronic portable peak flow meter. A mean of 3 measurements in the upright posture in bed before and after surgery will be used. (NCT01748643)
Timeframe: Measured the day before surgery and 30min after completion of surgery (when the modified observer's assessment of alertness/sedation scale is 5 (Patient responds readily to name spoken in normal tone))
| Intervention | percent change from baseline (Mean) |
|---|---|
| Deep Neuromuscular Blockade, Reversal With Sugammadex | 51.9 |
| Normal Neuromuscular Blockade, Reversal With Neostigmine | 49.0 |
The number of intra-abdominal pressure rises > 18cmH2O detected by the intra-abdominal CO2 insufflator. (NCT01748643)
Timeframe: Participants will be followed for the duration of the laparoscopic gastric bypass surgery, an expected average of 1.5h
| Intervention | number of intra-abdominal pressure rises (Mean) |
|---|---|
| Deep Neuromuscular Blockade, Reversal With Sugammadex | 0.2 |
| Normal Neuromuscular Blockade, Reversal With Neostigmine | 0.3 |
Peak expiratory flow is measured with the Vitalograph® electronic portable peak flow meter. A mean of 3 measurements in the upright posture in bed before and after surgery will be used. (NCT01748643)
Timeframe: Measured the day before surgery and 30min after completion of surgery (when the modified observer's assessment of alertness/sedation scale is 5 (Patient responds readily to name spoken in normal tone))
| Intervention | percent change from baseline (Mean) |
|---|---|
| Deep Neuromuscular Blockade, Reversal With Sugammadex | 51.3 |
| Normal Neuromuscular Blockade, Reversal With Neostigmine | 51.5 |
"At the end of surgery, the view on the operating field will be graded by the surgeon using a 5-point rating scale:~Extremely poor~Poor~Acceptable~Good~Optimal" (NCT01748643)
Timeframe: Participants will be followed for the duration of the laparoscopic gastric bypass surgery, an expected average of 1.5h
| Intervention | units on a scale (Mean) |
|---|---|
| Deep Neuromuscular Blockade, Reversal With Sugammadex | 4.2 |
| Normal Neuromuscular Blockade, Reversal With Neostigmine | 3.9 |
The monitoring of clinical signs of recovery was to be conducted based on the routine anesthetic procedures at each site. (NCT00724932)
Timeframe: Up to PACU discharge (up to ~4.5 hours)
| Intervention | participants (Number) |
|---|---|
| Sugammadex | NA |
| Neostigmine | NA |
Thirty days after administration of IMP, female participants of childbearing potential were asked whether they became pregnant during the trial and male participants were asked whether their partner (if of childbearing potential) became pregnant during the trial. (NCT00724932)
Timeframe: Up to 30 days after IMP administration
| Intervention | participants (Number) |
|---|---|
| Sugammadex | 0 |
| Neostigmine | 0 |
Clinical evidence of reoccurrence of NMB or residual NMB was assessed by oxygen saturation (by pulse oximetry) and breath frequency measurements as per routine practice after anesthesia and neuromuscular monitoring. (NCT00724932)
Timeframe: Up to 24 hours after IMP administration
| Intervention | participants (Number) |
|---|---|
| Sugammadex | 1 |
| Neostigmine | 0 |
Any evidence of events due to a possible interaction of sugammadex with endogenous compounds or with exogenous compounds other than rocuronium, was to be recorded. (NCT00724932)
Timeframe: Up to 7 days after IMP administration
| Intervention | participants (Number) |
|---|---|
| Sugammadex Only | 0 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds and assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the magnitudes (heights) of the 1st and 4th twitches, respectively, after TOF stimulation. The T4/T1 Ratio is expressed as a decimal of up to 1.0. A higher ratio indicates greater recovery from NMB. A decline in the T4/T1 ratio from >=0.9 (indicating a recovery from NMB) to <0.8 for at least three consecutive TOF values was considered to be a reoccurrence of NMB. (NCT00724932)
Timeframe: Up to 30 minutes after IMP administration
| Intervention | participants (Number) |
|---|---|
| Sugammadex | 0 |
| Neostigmine | 0 |
Events were to be collected for the entire period of neuromuscular transmission monitoring and were defined as an occurrence that resulted or could have resulted in: death; a serious deterioration in the state of health of a user; an occurrence which might, if it recurred, lead to death or serious deterioration in health; inaccuracy as well as any inadequacy in the labeling or instructions which could cause misuse or incorrect maintenance or adjustment which might lead to a death or serious deterioration in health; an examination of the medical device or the information supplied with the medical device indicated some factor with the potential for an incident involving death or serious deterioration in health; malfunction or deterioration in characteristics and/or performance of a medical device, which might lead to death, or serious deterioration in health; technical/medical recalls involving risk of death or serious deterioration in the state of health of the user. (NCT00724932)
Timeframe: From induction of anesthesia to recovery from NMB (up to ~3 hours)
| Intervention | participants (Number) |
|---|---|
| Sugammadex | 0 |
| Neostigmine | 0 |
The time of Operating Room discharge was defined as the actual time the participant was discharged from the Operating Room. The time of PACU discharge was defined as the actual time the participant was discharged from the PACU. (NCT00724932)
Timeframe: From actual Operating Room discharge to actual PACU discharge (up to ~4.4 hours)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 264 |
| Neostigmine | 207 |
The time of Operating Room discharge was defined as the actual time the participant was discharged from the Operating Room. The time of PACU discharge ready was defined as the time at which the participant had a Modified Aldrete Score >=9. The Modified Aldrete Score was to be assessed at PACU arrival, at 5, 15, 30, 45, 60 minutes after PACU arrival and every 15 minutes thereafter (if applicable) until the participant was ready to be discharged from the PACU. The Modified Aldrete Postoperative Recovery Score (range = 0-10) is calculated based on scores of 0 to 2 each for Activity, Respiration, Circulation, Consciousness and Oxygen Saturation, with a higher score indicating increased postoperative recovery. (NCT00724932)
Timeframe: From actual Operating Room discharge to PACU discharge ready (up to ~30 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 24 |
| Neostigmine | 29 |
The time of Operating Room admission was defined as the time at which the participant was physically placed into the Operating Room. The time of Operating Room discharge was defined as the actual time the participant was discharged from the Operating Room. (NCT00724932)
Timeframe: From Operating Room admission to actual Operating Room discharge (up to ~3 hours)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 158 |
| Neostigmine | 169 |
The time of Operating Room admission was defined as the time at which the participant was physically placed into the Operating Room. The time of Operating Room discharge ready was defined as time at which the participant had T4/T1 ratio of ≥0.9 and the participant's wound dressing was in place. (NCT00724932)
Timeframe: From Operating Room admission to Operating Room discharge ready (up to ~3 hours)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 154 |
| Neostigmine | 165 |
The time of Operating Room discharge ready was defined as time at which the participant had T4/T1 ratio of >=0.9 and the participant's wound dressing was in place. The time of Operating Room discharge was defined as the actual time the participant was discharged from the Operating Room. (NCT00724932)
Timeframe: From Operating Room discharge ready to actual Operating Room discharge (up to ~5 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 4 |
| Neostigmine | 5 |
The time of Operating Room discharge ready was defined as time at which the participant had T4/T1 ratio of >=0.9 and the participant's wound dressing was in place. The time of PACU discharge was defined as the actual time the participant was discharged from the PACU. (NCT00724932)
Timeframe: From Operating Room discharge ready to actual PACU discharge (up to ~4.5 hours)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 268 |
| Neostigmine | 210 |
The time of Operating Room discharge ready was defined as time at which the participant had T4/T1 ratio of >=0.9 and the participant's wound dressing was in place. The time of PACU discharge ready was defined as the time at which the participant had a Modified Aldrete Score >=9. The Modified Aldrete Score was to be assessed at PACU arrival, at 5, 15, 30, 45, 60 minutes after PACU arrival and every 15 minutes thereafter (if applicable) until the participant was ready to be discharged from the PACU. The Modified Aldrete Postoperative Recovery Score (range = 0-10) is calculated based on scores of 0 to 2 each for Activity, Respiration, Circulation, Consciousness and Oxygen Saturation, with a higher score indicating increased postoperative recovery. (NCT00724932)
Timeframe: From Operating Room discharge ready to PACU discharge ready (up to ~33 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 28 |
| Neostigmine | 33 |
The time of PACU admit was defined as the actual time the participant was admitted to the PACU. The time of PACU discharge was defined as the actual time the participant was discharged from the PACU. (NCT00724932)
Timeframe: From PACU admit to actual PACU discharge (up to ~4.3 hours)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 260 |
| Neostigmine | 203 |
The time of PACU admit was defined as the actual time the participant was admitted to the PACU. The time of PACU discharge ready was defined as the time at which the participant had a Modified Aldrete Score >=9. The Modified Aldrete Score was to be assessed at PACU arrival, at 5, 15, 30, 45, 60 minutes after PACU arrival and every 15 minutes thereafter (if applicable) until the participant was ready to be discharged from the PACU. The Modified Aldrete Postoperative Recovery Score (range = 0-10) is calculated based on scores of 0 to 2 each for Activity, Respiration, Circulation, Consciousness and Oxygen Saturation, with a higher score indicating increased postoperative recovery. (NCT00724932)
Timeframe: From PACU admit to PACU discharge ready (up to ~25 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 20 |
| Neostigmine | 25 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds & assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the magnitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0). A faster time to recovery of the T4/T1 Ratio to 0.7 indicates a faster recovery from NMB. (NCT00724932)
Timeframe: From start of IMP administration to recovery of T4/T1 Ratio to 0.7 (ranging from ~2 minutes to ~5 minutes)
| Intervention | minutes (Geometric Mean) |
|---|---|
| Sugammadex | 1.6 |
| Neostigmine | 4.1 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds & assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the magnitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0). A faster time to recovery of the T4/T1 Ratio to 0.8 indicates a faster recovery from NMB. (NCT00724932)
Timeframe: From start of IMP administration to recovery of T4/T1 Ratio to 0.8 (ranging from ~2 minutes to ~6 minutes)
| Intervention | minutes (Geometric Mean) |
|---|---|
| Sugammadex | 1.9 |
| Neostigmine | 5.6 |
Neuromuscular functioning was monitored by applying repetitive Train-Of-Four (TOF) electrical stimulations to the ulnar nerve every 15 seconds & assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the magnitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0) indicates the extent of recovery from neuromuscular blockade (NMB). In this study, twitch responses were recorded until the T4/T1 Ratio reached >= 0.9, the minimum acceptable ratio that indicated recovery from NMB. A faster time to recovery of the T4/T1 Ratio to 0.9 indicates a faster recovery from NMB. (NCT00724932)
Timeframe: From start of IMP administration to recovery of T4/T1 ratio to 0.9 (ranging from ~2 minutes to ~9 minutes)
| Intervention | minutes (Geometric Mean) |
|---|---|
| Sugammadex | 2.4 |
| Neostigmine | 8.4 |
The time of 1-2 PTC refers to when 1-2 twitches are generated after tetanic stimulation. Time to 1-2 PTC is the time point of the last single twitch >0 or baseline (in case of noise or direct stimulation) within the sequence of a PTC measurement. 1-2 PTC was the target depth of NMB at which sugammadex was to be administered. (NCT00724932)
Timeframe: From last dose of rocuronium to 1-2 PTC (up to ~9 minutes)
| Intervention | minutes (Geometric Mean) |
|---|---|
| Sugammadex Only | 8.9 |
The time of reappearance of T2 refers to when the second twitch reappears after TOF stimulation. Reappearance of T2 was the target depth of NMB at which neostigmine was to be administered. (NCT00724932)
Timeframe: From last dose of rocuronium to reappearance of T2 (up to ~26 minutes)
| Intervention | minutes (Geometric Mean) |
|---|---|
| Neostigmine Only | 25.6 |
The time of IMP administration was defined as the actual time at which IMP administration was started. The time of Operating Room discharge was defined as the actual time at which the participant was discharged from the Operating Room. (NCT00724932)
Timeframe: From start of IMP administration to actual Operating Room discharge (up to ~26 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 19 |
| Neostigmine | 26 |
The time of IMP administration was defined as the actual time at which IMP administration was started. The time of Operating Room discharge ready was defined as time at which the participant had T4/T1 ratio of >=0.9 and the participant's wound dressing was in place. (NCT00724932)
Timeframe: From start of IMP administration to Operating Room discharge ready (up to ~21 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 15 |
| Neostigmine | 21 |
The time of IMP administration was defined as the actual time at which IMP administration was started. The time of tracheal extubation was defined as the actual time at which the participant was extubated. (NCT00724932)
Timeframe: From start of IMP administration to tracheal extubation (up to ~21 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 14 |
| Neostigmine | 21 |
The time of tracheal extubation was defined as the actual time at which the participant was extubated. The time of Operating Room discharge was defined as the actual time at which the participant was discharged from the Operating Room. (NCT00724932)
Timeframe: From tracheal extubation to actual OR discharge (up to ~5 minutes)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 5 |
| Neostigmine | 5 |
The time of tracheal extubation was defined as the actual time at which the participant was extubated. The time of Operating Room discharge ready was defined as time at which the participant had T4/T1 ratio of >=0.9 and the participant's wound dressing was in place. (NCT00724932)
Timeframe: From tracheal extubation to Operating Room discharge ready (up to ~1 minute)
| Intervention | minutes (Mean) |
|---|---|
| Sugammadex | 1 |
| Neostigmine | 0 |
Diastolic Blood Pressure was measured at screening, before start of rocuronium administration, before start of IMP administration, at 2, 5, 10, 30 minutes post-IMP administration, and at the post-anesthetic visit (the day after surgery). (NCT00724932)
Timeframe: At screening, pre-rocuronium, pre-IMP, at 2, 5, 10, and 30 minutes post-IMP, and at the post-anesthetic visit (the day after surgery)
| Intervention | mm Hg (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Screening | Pre-rocuronium | Pre-IMP | 2 minutes post-IMP (N=65, N=65) | 5 minutes post-IMP | 10 minutes post-IMP (N=66, N=66) | 30 minutes post-IMP (N=65, N=66) | Post-anesthetic visit (N=66, N=66) | |
| Neostigmine | 82.8 | 58.3 | 72.5 | 72.6 | 69.2 | 68.7 | 73.1 | 75.2 |
| Sugammadex | 80.9 | 58.2 | 72.8 | 73.4 | 72.4 | 71.8 | 74.3 | 76.7 |
Heart Rate was measured at screening, before start of rocuronium administration, before start of IMP administration, at 2, 5, 10, 30 minutes post-IMP administration, and at the post-anesthetic visit (the day after surgery). (NCT00724932)
Timeframe: At screening, pre-rocuronium, pre-IMP, at 2, 5, 10, and 30 minutes post-IMP, and at the post-anesthetic visit (the day after surgery)
| Intervention | beats per minute (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Screening | Pre-rocuronium | Pre-IMP | 2 minutes post-IMP (N=65, N=65) | 5 minutes post-IMP | 10 minutes post-IMP (N=66, N=66) | 30 minutes post-IMP (N=65, N=66) | Post-anesthetic visit (N=66, N=66) | |
| Neostigmine | 74.6 | 63.6 | 68.0 | 65.3 | 57.1 | 56.3 | 65.1 | 71.9 |
| Sugammadex | 72.9 | 63.4 | 68.3 | 66.0 | 64.9 | 67.3 | 73.1 | 72.7 |
Systolic Blood Pressure was measured at screening, before start of rocuronium administration, before start of IMP administration, at 2, 5, 10, 30 minutes post-IMP administration, and at the post-anesthetic visit (the day after surgery). (NCT00724932)
Timeframe: At screening, pre-rocuronium, pre-IMP, at 2, 5, 10, and 30 minutes post-IMP, and at the post-anesthetic visit (the day after surgery)
| Intervention | mm Hg (Mean) | |||||||
|---|---|---|---|---|---|---|---|---|
| Screening | Pre-rocuronium | Pre-IMP | 2 minutes post-IMP (N=65, N=65) | 5 minutes post-IMP | 10 minutes post-IMP (N=66, N=66) | 30 minutes post-IMP (N=65, N=66) | Post-anesthetic visit (N=66, N=66) | |
| Neostigmine | 133.9 | 101.6 | 121.3 | 122.5 | 118.0 | 119.3 | 131.7 | 125.4 |
| Sugammadex | 132.7 | 98.2 | 122.1 | 122.5 | 122.6 | 124.0 | 132.9 | 127.3 |
An AE is defined as any unfavorable and unintended change in the structure, function, or chemistry of the body, whether or not considered related to the use of the product. Participants were monitored for occurrence AEs for up to 7 days after last dose IMP. Pre-treatment refers to the period from signing of the informed consent up to start of IMP administration. Post-treatment refers to the period from start of IMP administration to 7 days after IMP administration. (NCT00724932)
Timeframe: From signing of informed consent to end of trial (7 days after surgery)
| Intervention | participants (Number) | |
|---|---|---|
| Pre-treatment non-serious AE | Post-treatment non-serious AE | |
| Neostigmine | 34 | 65 |
| Sugammadex | 38 | 65 |
"An SAE is defined as any untoward medical occurrence that at any dose: results in death; is life-threatening; requires in-patient hospitalization or prolongation of existing hospitalization; results in persistent or significant disability/incapacity; or is a congenital anomaly/birth defect.~Participants were monitored for occurrence SAEs for up to 7 days after last dose IMP. Pre-treatment refers to the period from signing of the informed consent up to start of IMP administration. Post-treatment refers to the period from start of IMP administration to 7 days after IMP administration." (NCT00724932)
Timeframe: From signing of informed consent to end of trial (7 days after surgery)
| Intervention | participants (Number) | |
|---|---|---|
| Pre-treatment SAE | Post-treatment SAE | |
| Neostigmine | 0 | 6 |
| Sugammadex | 1 | 4 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds & assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the magnitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0). Faster times to recovery of the T4/T1 Ratios to 0.5 and 0.6 indicate faster recoveries from NMB. (NCT00724932)
Timeframe: From start of IMP administration to recovery of T4/T1 Ratio to 0.5 and 0.6 (ranging from ~1 minute to ~4 minutes)
| Intervention | minutes (Geometric Mean) | |
|---|---|---|
| Recovery of T4/T1 Ratio to 0.5 | Recovery of T4/T1 Ratio to 0.6 | |
| Neostigmine | 2.8 | 3.4 |
| Sugammadex | 1.3 | 1.5 |
Neuromuscular functioning was monitored by applying repetitive TOF electrical stimulations to the ulnar nerve every 15 seconds & assessing twitch response at the adductor pollicis muscle. T1 and T4 refer to the magnitudes (heights) of the first and fourth twitches, respectively, after TOF nerve stimulation. The T4/T1 Ratio (expressed as a decimal of up to 1.0). A faster time to recovery of the T4/T1 Ratio indicates a faster recovery from NMB. (NCT00724932)
Timeframe: From start of last dose of rocuronium to recovery of T4/T1 Ratio to 0.5, 0.6, 0.7, 0.8 and 0.9 (ranging from ~12 minutes to ~36 minutes)
| Intervention | minutes (Geometric Mean) | ||||
|---|---|---|---|---|---|
| Recovery of T4/T1 ratio to 0.5 | Recovery of T4/T1 ratio to 0.6 | Recovery of T4/T1 ratio to 0.7 | Recovery of T4/T1 ratio to 0.8 | Recovery of T4/T1 ratio to 0.9 (N=65, N=61) | |
| Neostigmine | 30.0 | 30.7 | 31.6 | 33.2 | 35.2 |
| Sugammadex | 11.7 | 11.9 | 12.1 | 12.5 | 13.3 |
"The clinical duration is the elapsed time for T1 recovery = 25% (Dur25%) of the original value of T1 after the infusion of cisatracurium.~This outcome meansure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | minutes (Median) |
|---|---|
| Group M | 82.68 |
| Group ML | 86.33 |
| Group C | 64.8 |
"The final recovery index is the elapsed time between the T1 recovery = 25% (Dur25%) and T4 / T1 = 80% (TOF = 80%) after the infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | minutes (Mean) |
|---|---|
| Group M | 27.97 |
| Group ML | 33.81 |
| Group C | 21.51 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The measure of heart rate was recorded and annotated at various times such as in the arrival of the patient in the operating room. This time point was named as moment '1'. (NCT02483611)
Timeframe: This measure of heart rate was performed when the patient arrived in the operating room
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 79.94 |
| Group ML | 77.25 |
| Group C | 73.66 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as in the moment immediately before the anesthesia induction. This time point was named as moment '2'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before induction of anesthesia
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 74.69 |
| Group ML | 73.69 |
| Group C | 75.40 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution). This time point was named as moment '3'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution)
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 72.94 |
| Group ML | 74.19 |
| Group C | 75.40 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as in the end of the study solutions infusion. This time point was named as moment '4'. (NCT02483611)
Timeframe: This measure of heart rate was performed five minutes after M3 (in the end of the X and Y solutions infusion)
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 71.94 |
| Group ML | 72.25 |
| Group C | 65.07 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as immediately before the tracheal intubation. This time point was named as moment '5'. (NCT02483611)
Timeframe: This measure of heart rate was performed immediately before the tracheal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 67.56 |
| Group ML | 69.31 |
| Group C | 64.27 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as one minute after the tracheal intubation. This time point was named as moment '6'. (NCT02483611)
Timeframe: This measure of heart rate was performed one minute after the tracheal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 66.50 |
| Group ML | 68.19 |
| Group C | 65.13 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 15 minutes after the traqueal intubation.This time point was named as moment '7a'. (NCT02483611)
Timeframe: This measure of heart rate was performed 15 minutes after the traqueal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 68.94 |
| Group ML | 68.19 |
| Group C | 67.13 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 30 minutes after the traqueal intubation. This time point was named as moment '7b'. (NCT02483611)
Timeframe: This measure of heart rate was performed 30 minutes after the traqueal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 67.44 |
| Group ML | 68.38 |
| Group C | 64.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 45 minutes after the traqueal intubation. This time point was named as moment '7c'. (NCT02483611)
Timeframe: This measure of heart rate was performed 45 minutes after the traqueal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 65.75 |
| Group ML | 65.75 |
| Group C | 62.33 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 60 minutes after the traqueal intubation. This time point was named as moment '7d'. (NCT02483611)
Timeframe: This measure of heart rate was performed 60 minutes after the traqueal intubation
| Intervention | beats/min (Mean) |
|---|---|
| Group M | 66.19 |
| Group ML | 65.31 |
| Group C | 61.93 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 75 minutes after the traqueal intubation. This time point was named as moment '7e'. (NCT02483611)
Timeframe: This measure of heart rate was performed 75 minutes after the traqueal intubation
| Intervention | beats/min (Median) |
|---|---|
| Group M | 66.50 |
| Group ML | 63.00 |
| Group C | 58.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The heart rate was recorded and annotated at various times such as 90 minutes after the traqueal intubation. This time point was named as moment '7f'. (NCT02483611)
Timeframe: This measure of heart rate was performed 90 minutes after the traqueal intubation
| Intervention | beats/min (Median) |
|---|---|
| Group M | 66.00 |
| Group ML | 61.00 |
| Group C | 61.00 |
"The latency is computed as the elapsed time to reduce the response of T1 to 5% of the initial contraction force after the infusion of cisatracurium.~This outcome meansure was presented in seconds." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | seconds (Mean) |
|---|---|
| Group M | 139.70 |
| Group ML | 151.30 |
| Group C | 147.80 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the arrival of the patient in the operating room. This time point was named as moment '1'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed when the patient arrived in the operating room
| Intervention | mmHg (Mean) |
|---|---|
| Group M | 94.63 |
| Group ML | 88.75 |
| Group C | 100.10 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the moment immediately before the anesthesia induction. This time point was named as moment '2'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before induction of anesthesia
| Intervention | mmHg (Mean) |
|---|---|
| Group M | 87.63 |
| Group ML | 84.69 |
| Group C | 92.47 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution). This time point was named as moment '3'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before the start of the infusion of the solution X (magnesium sulfate or isotonic solution) and Y solution (lidocaine or isotonic solution)
| Intervention | mmHg (Mean) |
|---|---|
| Group M | 75.88 |
| Group ML | 73.88 |
| Group C | 76.73 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as in the end of the study solutions infusion.This time point was named as moment '4'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed five minutes after M3 (in the end of the X and Y solutions infusion)
| Intervention | mmHg (Median) |
|---|---|
| Group M | 69.00 |
| Group ML | 63.00 |
| Group C | 74.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as immediately before the tracheal intubation. This time point was named as moment '5'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed immediately before the tracheal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 62.50 |
| Group ML | 61.50 |
| Group C | 67.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as one minute after the tracheal intubation. This time point was named as moment '6'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed one minute after the tracheal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 64.50 |
| Group ML | 64.00 |
| Group C | 69.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 15 minutes after the traqueal intubation. This time point was named as moment '7a'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 15 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 66.00 |
| Group ML | 61.50 |
| Group C | 69.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 30 minutes after the traqueal intubation. This time point was named as moment '7b'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 30 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 66.50 |
| Group ML | 63.50 |
| Group C | 68.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 45 minutes after the traqueal intubation. This time point was named as moment '7c'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 45 minutes after the traqueal intubation
| Intervention | mmHg (Mean) |
|---|---|
| Group M | 69.25 |
| Group ML | 63.00 |
| Group C | 69.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 60 minutes after the traqueal intubation. This time point was named as moment '7d'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 60 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 68.00 |
| Group ML | 62.00 |
| Group C | 66.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 75 minutes after the traqueal intubation. This time point was named as moment '7e'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 75 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 68.00 |
| Group ML | 66.00 |
| Group C | 69.00 |
In the operating room, patients were cardiovascular, respiratory and body temperature monitored through the Dixtal 2020. The mean blood pressure was recorded and annotated at various times such as 90 minutes after the traqueal intubation. This time point was named as moment '7f'. (NCT02483611)
Timeframe: This measure of average blood pressure was performed 90 minutes after the traqueal intubation
| Intervention | mmHg (Median) |
|---|---|
| Group M | 64.00 |
| Group ML | 64.50 |
| Group C | 72.00 |
"The recovery index is the elapsed time between the T1 recovery =25% (Dur25%) and T1 =75% (Dur75%) after the infusion of cisatracurium.~This outcome meansure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | minutes (Mean) |
|---|---|
| Group M | 20.08 |
| Group ML | 20.26 |
| Group C | 14.53 |
"Spontaneous recovery is the elapsed time for the recovery of the TOF (T4 / T1) response to 90% of the original after infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: The participants were followed during the anesthetic - surgical procedure
| Intervention | minutes (Mean) |
|---|---|
| Group M | 120.20 |
| Group ML | 126.70 |
| Group C | 90.03 |
"The total duration is the elapsed time for T1 recovery of the response to reach 95% of the initial after the infusion of cisatracurium.~This outcome measure was presented in minutes." (NCT02483611)
Timeframe: Participants were followed during the anesthetic - surgical procedure, an average of 90 minutes
| Intervention | minutes (Mean) |
|---|---|
| Group M | 113.20 |
| Group ML | 120.10 |
| Group C | 88.19 |
7 reviews available for neostigmine and Muscle Contraction
| Article | Year |
|---|---|
[Human myasthenia: a metabolic disease of the motor neuron].
Topics: Acetylcholine; Axonal Transport; Cholinesterase Inhibitors; Humans; Intention; Models, Neurological; | 1973 |
The irritable colon syndrome.
Topics: Animals; Cats; Cholecystokinin; Colon; Colonic Diseases, Functional; Dietary Fiber; Digestive System | 1982 |
Anaesthesia and bowel surgery.
Topics: Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anesthetics; Animals; Carbon Dioxide; Gastro | 1984 |
[Acid base changes and muscle relaxants].
Topics: Acid-Base Equilibrium; Acidosis, Respiratory; Animals; Hydrogen-Ion Concentration; Muscle Contractio | 1996 |
Myasthenia gravis as a receptor disorder.
Topics: Acetylcholine; Action Potentials; Animals; Binding Sites; Bungarotoxins; Curare; Disease Models, Ani | 1976 |
Structure-activity relationship of reversible cholinesterase inhibitors: activation, channel blockade and stereospecificity of the nicotinic acetylcholine receptor-ion channel complex.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry; Cholinesterase Inhibitors; Edrophonium; Muscl | 1988 |
New curare-like agents.
Topics: Acetylcholine; Action Potentials; Anesthetics; Animals; Cats; Chemical Phenomena; Chemistry; Ethyl E | 1974 |
36 trials available for neostigmine and Muscle Contraction
| Article | Year |
|---|---|
Effects of neostigmine or edrophonium on force of contraction when administered at a train-of-four ratio of 0.9 in anesthetized dogs.
Topics: Anesthesia, General; Animals; Cross-Over Studies; Dogs; Edrophonium; Muscle Contraction; Neostigmine | 2017 |
Antagonism of alcuronium with edrophonium or neostigmine.
Topics: Alcuronium; Edrophonium; Humans; Muscle Contraction; Neostigmine; Neuromuscular Junction; Ophthalmol | 1984 |
Clinical studies on Org NC 45: comparison with pancuronium.
Topics: Blood Pressure; Heart Rate; Humans; Intraoperative Period; Intubation, Intratracheal; Muscle Contrac | 1982 |
Neuromuscular blocking effects of vecuronium and pancuronium during halothane anaesthesia.
Topics: Adult; Anesthesia, Inhalation; Female; Halothane; Humans; Muscle Contraction; Neostigmine; Neuromusc | 1983 |
Dose-response relationships and neuromuscular blocking effects of vecuronium pancuronium during ketamine anaesthesia.
Topics: Adult; Anesthesia, Intravenous; Dose-Response Relationship, Drug; Female; Humans; Ketamine; Muscle C | 1984 |
Effect of hypocarbia and hypercarbia on the antagonism of pancuronium-induced neuromuscular blockade with neostigmine in man.
Topics: Adult; Carbon Dioxide; Female; Humans; Hydrogen-Ion Concentration; Male; Middle Aged; Muscle Contrac | 1982 |
Recovery characteristics following antagonism of atracurium with neostigmine or edrophonium.
Topics: Adult; Atracurium; Edrophonium; Humans; Isoquinolines; Muscle Contraction; Neostigmine; Neuromuscula | 1984 |
Impaired neostigmine antagonism of pancuronium during enflurane anaesthesia in man.
Topics: Adult; Aged; Anesthesia, Inhalation; Drug Interactions; Enflurane; Halothane; Humans; Middle Aged; M | 1982 |
Reversal of doxacurium and pancuronium neuromuscular blockade with neostigmine in children.
Topics: Anesthesia Recovery Period; Anesthesia, General; Child; Child, Preschool; Dose-Response Relationship | 1994 |
Neuromuscular and cardiovascular effects of neostigmine and methyl-atropine administered at different degrees of rocuronium-induced neuromuscular block.
Topics: Adult; Androstanols; Anesthesia Recovery Period; Atropine Derivatives; Drug Combinations; Electric S | 1994 |
Recovery characteristics after early administration of anticholinesterases during intense mivacurium-induced neuromuscular block.
Topics: Adolescent; Adult; Anesthesia Recovery Period; Cholinesterase Inhibitors; Edrophonium; Electric Stim | 1995 |
Recovery of neuromuscular function after atracurium and pancuronium maintenance of pancuronium block.
Topics: Adult; Anesthesia Recovery Period; Atracurium; Drug Interactions; Female; Glycopyrrolate; Humans; Ma | 1994 |
Dose-response relationships for edrophonium and neostigmine antagonism of rocuronium bromide (ORG 9426)-induced neuromuscular blockade.
Topics: Adult; Androstanols; Dose-Response Relationship, Drug; Drug Interactions; Edrophonium; Electric Stim | 1993 |
Dose-response relationships for edrophonium and neostigmine antagonism of mivacurium-induced neuromuscular block.
Topics: Adolescent; Adult; Dose-Response Relationship, Drug; Edrophonium; Female; Humans; Isoquinolines; Mal | 1993 |
Rectal wall contractility in healthy subjects and in patients with chronic severe constipation.
Topics: Adult; Chronic Disease; Constipation; Female; Glucagon; Humans; Male; Manometry; Muscle Contraction; | 1993 |
Administration of 51W89 by infusion--a comparison with atracurium--preliminary communication.
Topics: Anesthesia Recovery Period; Anesthesia, Inhalation; Atracurium; Atropine; Cholinesterase Inhibitors; | 1995 |
Optimum time for neostigmine administration to antagonize vecuronium-induced neuromuscular blockade.
Topics: Adult; Anesthesia Recovery Period; Anesthetics, Intravenous; Cholinesterase Inhibitors; Droperidol; | 1995 |
A comparison of cisatracurium and atracurium: onset of neuromuscular block after bolus injection and recovery after subsequent infusion.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Atracurium; Atropine; Cholinesterase Inhibitors | 1996 |
Recovery from mivacurium block with or without anticholinesterase following continuous infusion in obstetric patients.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intrav | 1996 |
The clinical neuromuscular pharmacology of cisatracurium versus vecuronium during outpatient anesthesia.
Topics: Adolescent; Adult; Ambulatory Surgical Procedures; Anesthesia; Atracurium; Dose-Response Relationshi | 1997 |
Tactile evaluation of the response to double burst stimulation decreases, but does not eliminate, the problem of postoperative residual paralysis.
Topics: Abdomen; Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Electric Stimulation; Female; Hu | 1998 |
Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium.
Topics: Adult; Aged; Aging; Cholinesterase Inhibitors; Drug Interactions; Edrophonium; Female; Humans; Isoqu | 2000 |
Clinical neuromuscular pharmacology of AH 8165 D, an azobis-arylimidazo-pyridinium-compound.
Topics: Adult; Cardiac Output; Dose-Response Relationship, Drug; Drug Evaluation; Female; Heart Rate; Humans | 1975 |
Effect of doxapram on neostigmine evoked antagonism of vecuronium neuromuscular block.
Topics: Adult; Anesthesia, General; Depression, Chemical; Double-Blind Method; Doxapram; Drug Interactions; | 1992 |
Neuromuscular block with doxacurium (BW A938U) in patients with normal or absent renal function.
Topics: Adult; Aged; Anesthesia, General; Drug Evaluation; Edrophonium; Female; Hemodynamics; Humans; Isoqui | 1990 |
Effect of epidurally administered bupivacaine on atracurium-induced neuromuscular blockade.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, Epidural; Anesthesia, Intravenous; Atracurium; Blood | 1990 |
"Priming" with neostigmine: failure to accelerate reversal of single twitch and train-of-four responses.
Topics: Anesthesia Recovery Period; Atracurium; Clinical Trials as Topic; Electric Stimulation; Female; Huma | 1989 |
Effects of a 5-hydroxytryptamine3 receptor antagonist (ICS 205-930) on colonic motor activity in healthy men.
Topics: Adult; Colon; Fasting; Gastrointestinal Motility; Humans; Indoles; Male; Muscle Contraction; Muscle, | 1989 |
Antagonism of profound neuromuscular blockade induced by vecuronium or atracurium. Comparison of neostigmine with edrophonium.
Topics: Adult; Atracurium; Edrophonium; Humans; Middle Aged; Muscle Contraction; Neostigmine; Neuromuscular | 1986 |
Antagonism of vecuronium-induced neuromuscular blockade with edrophonium or neostigmine.
Topics: Adult; Edrophonium; Humans; Muscle Contraction; Neostigmine; Time Factors; Vecuronium Bromide | 1987 |
Antagonism of vecuronium and atracurium: comparison of neostigmine and edrophonium administered at 5% twitch height recovery.
Topics: Adult; Atracurium; Edrophonium; Humans; Muscle Contraction; Neostigmine; Time Factors; Vecuronium Br | 1987 |
Priming with anti-cholinesterases--the effect of different combinations of anti-cholinesterases and different priming intervals.
Topics: Adult; Anesthesia Recovery Period; Atracurium; Drug Administration Schedule; Edrophonium; Female; Hu | 1988 |
Reversal of pancuronium. Neuromuscular and cardiovascular effects of a mixture of neostigmine and glycopyrronium.
Topics: Adolescent; Adult; Aged; Dose-Response Relationship, Drug; Drug Combinations; Glycopyrrolate; Heart | 1988 |
Dose-response curves for edrophonium, neostigmine, and pyridostigmine after pancuronium and d-tubocurarine.
Topics: Adult; Dose-Response Relationship, Drug; Edrophonium; Female; Humans; Male; Middle Aged; Muscle Cont | 1987 |
A comparison of atracurium and alcuronium during halothane anaesthesia by measurement of the train-of-four response of the adductor pollicis muscle and clinical observation.
Topics: Adult; Alcuronium; Anesthesia, Inhalation; Atracurium; Female; Halothane; Humans; Intubation, Intrat | 1985 |
Controlled relaxation. II. Clinical management of muscle-relaxant administration.
Topics: Abdominal Muscles; Adult; Aged; Anesthesia; Clinical Trials as Topic; Electric Stimulation; Female; | 1966 |
392 other studies available for neostigmine and Muscle Contraction
| Article | Year |
|---|---|
Evidence for tetrodotoxin-resistant spontaneous myogenic contractions of mouse isolated stomach that are dependent on acetylcholine.
Topics: Acetylcholine; Animals; Atropine; Electric Stimulation; Mice; Muscle Contraction; Neostigmine; Stoma | 2022 |
In Situ Effects of Doxycycline on Neuromuscular Junction in Mice.
Topics: Animals; Cholinesterases; Doxycycline; Mice; Muscle Contraction; Neostigmine; Neuromuscular Junction | 2022 |
Ca2+ sensitization pathways accessed by cholinergic neurotransmission in the murine gastric fundus.
Topics: Animals; Calcium; Cholinergic Fibers; Electric Stimulation; Gastric Fundus; Interstitial Cells of Ca | 2013 |
Bidirectional effects of methanol extract of Wei-Chang-An pill on gastrointestinal transit and the spasmolytic activity on isolated rat jejunum.
Topics: Acetylcholine; Animals; Calcium; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Female; Ga | 2014 |
Reactivity of diabetic urinary bladder to the cholinesterase inhibitor neostigmine.
Topics: Animals; Cholinesterase Inhibitors; Diabetes Mellitus, Experimental; Disease Models, Animal; Electri | 2014 |
Motilin-induced gastric contractions signal hunger in man.
Topics: Appetite; Cholinesterase Inhibitors; Duodenum; Eating; Erythromycin; Gastrointestinal Motility; Ghre | 2016 |
Acotiamide Hydrochloride, a Therapeutic Agent for Functional Dyspepsia, Enhances Acetylcholine-induced Contraction via Inhibition of Acetylcholinesterase Activity in Circular Muscle Strips of Guinea Pig Stomach.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Benzamides; Benzyl Compounds; Carbachol; Cholinesteras | 2016 |
Haustral boundary contractions in the proximal 3-taeniated rabbit colon.
Topics: Animals; Bethanechol; Biological Clocks; Colon; Electrophysiological Phenomena; Female; Gastrointest | 2016 |
Ultrasound induces contraction of the bladder smooth muscle.
Topics: Animals; Chi-Square Distribution; Cohort Studies; Female; Follow-Up Studies; Humans; Muscle Contract | 2016 |
Electroporation-delivered transdermal neostigmine in rats: equivalent action to intravenous administration.
Topics: Administration, Cutaneous; Administration, Intravenous; Animals; Dose-Response Relationship, Drug; D | 2016 |
Night cramps in human extremities; a clinical study of the physiologic action of quinine and prostigmine upon the spontaneous contractions of resting muscles.
Topics: Biomedical Research; Blood Vessels; Humans; Muscle Contraction; Muscle Cramp; Neostigmine; Permeabil | 1948 |
Calcium and neostigmine antagonize gentamicin, but augment clindamycin-induced tetanic fade in rat phrenic nerve-hemidiaphragm preparations.
Topics: Animals; Anti-Bacterial Agents; Calcium; Clindamycin; Diaphragm; Electric Stimulation; Gentamicins; | 2008 |
High spatial resolution studies of muscarinic neuroeffector junctions in mouse isolated vas deferens.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Antagonists; Age Factors; Animals; Calcium; Cholinesteras | 2009 |
Modulation of slow waves by transmural nerve stimulation of smooth muscle tissue isolated from the corpus of the guinea-pig stomach.
Topics: Acetylcholine; Animals; Apamin; Atropine; Dose-Response Relationship, Drug; Electric Stimulation; Gu | 2009 |
The effect of memantine and levodopa/carbidopa on the responses of phrenic nerve-diaphragm preparations from aged rats.
Topics: Aging; Animals; Carbidopa; Diaphragm; Electric Stimulation; Gallamine Triethiodide; Gene Expression | 2009 |
The ACB technique: a biomagentic tool for monitoring gastrointestinal contraction directly from smooth muscle in dogs.
Topics: Animals; Butylscopolammonium Bromide; Colon; Dogs; Eating; Electrodes, Implanted; Electromagnetic Fi | 2010 |
Investigation of enhancement effects of nicotine on cholinergic neurotransmission in isolated rabbit gastric fundus: role of antioxidants.
Topics: Acetylcholine; Allopurinol; Animals; Antioxidants; Atropine; Cholinergic Fibers; Deferoxamine; Elect | 2010 |
Relative contribution of pre- and post-synaptic effects to the neostigmine-induced recovery of neuromuscular transmission blocked by vecuronium.
Topics: Animals; Cholinesterase Inhibitors; Electric Stimulation; Electrophysiological Phenomena; Female; Ma | 2011 |
Contribution of cyclooxygenase-dependent mechanisms to contractile responses to donepezil in the rat urinary bladder.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Donepezil; Indans; Indomethacin; Male; Muscle Contract | 2010 |
Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.
Topics: Adult; Air Pressure; Androstanols; Anesthesia Recovery Period; Cholinesterase Inhibitors; Electric S | 2010 |
Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.
Topics: Adult; Air Pressure; Androstanols; Anesthesia Recovery Period; Cholinesterase Inhibitors; Electric S | 2010 |
Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.
Topics: Adult; Air Pressure; Androstanols; Anesthesia Recovery Period; Cholinesterase Inhibitors; Electric S | 2010 |
Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.
Topics: Adult; Air Pressure; Androstanols; Anesthesia Recovery Period; Cholinesterase Inhibitors; Electric S | 2010 |
Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.
Topics: Adult; Air Pressure; Androstanols; Anesthesia Recovery Period; Cholinesterase Inhibitors; Electric S | 2010 |
Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.
Topics: Adult; Air Pressure; Androstanols; Anesthesia Recovery Period; Cholinesterase Inhibitors; Electric S | 2010 |
Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.
Topics: Adult; Air Pressure; Androstanols; Anesthesia Recovery Period; Cholinesterase Inhibitors; Electric S | 2010 |
Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.
Topics: Adult; Air Pressure; Androstanols; Anesthesia Recovery Period; Cholinesterase Inhibitors; Electric S | 2010 |
Neostigmine/glycopyrrolate administered after recovery from neuromuscular block increases upper airway collapsibility by decreasing genioglossus muscle activity in response to negative pharyngeal pressure.
Topics: Adult; Air Pressure; Androstanols; Anesthesia Recovery Period; Cholinesterase Inhibitors; Electric S | 2010 |
Regional differences in neostigmine-induced contraction and relaxation of stomach from diabetic guinea pig.
Topics: Animals; Autonomic Nervous System Diseases; Diabetes Mellitus, Experimental; Diabetic Neuropathies; | 2011 |
Role of interstitial cells of Cajal in the generation and modulation of motor activity induced by cholinergic neurotransmission in the stomach.
Topics: Acetylcholine; Animals; Atropine; Cholinesterase Inhibitors; Electrophysiology; Enteric Nervous Syst | 2011 |
Neostigmine-induced contraction and nitric oxide-induced relaxation of isolated ileum from STZ diabetic guinea pigs.
Topics: Animals; Diabetes Mellitus, Experimental; Endothelium-Dependent Relaxing Factors; Gastrointestinal M | 2011 |
Neuromuscular activity of the venoms of the Colombian coral snakes Micrurus dissoleucus and Micrurus mipartitus: an evolutionary perspective.
Topics: Animals; Chickens; Elapid Venoms; Elapidae; In Vitro Techniques; Muscle Contraction; Neostigmine; Ne | 2012 |
Inhibitory effects of atropine and hexamethonium on the angiotensin II-induced contractions of rat anococcygeus smooth muscles.
Topics: Angiotensin II; Animals; Atropine; Cholinergic Antagonists; Cholinesterase Inhibitors; Depression, C | 2003 |
The role of cholinesterases in rat urinary bladder contractility.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; In Vitro Techniques | 2003 |
Effects of isoeugenol on in vitro neuromuscular blockade of rat phrenic nerve-diaphragm preparations.
Topics: Anesthetics, Local; Animals; Benzocaine; Diaphragm; Drug Therapy, Combination; Eugenol; In Vitro Tec | 2003 |
Effects of ketamine on neostigmine-induced contractile and phosphatidylinositol responses of the rat trachea.
Topics: Aluminum Compounds; Anesthetics, Intravenous; Animals; Cholinesterase Inhibitors; Dose-Response Rela | 2003 |
Facilitation of neuromuscular transmission by anticholinesterase drugs.
Topics: Acetylcholine; Ambenonium Chloride; Cholinesterase Inhibitors; Cholinesterases; Edrophonium; Electri | 1963 |
THE MODE OF ACTION OF NEOSTIGMINE AND PHYSOSTIGMINE ON THE GUINEA-PIG TRACHEALIS MUSCLE.
Topics: Acetylcholine; Animals; Atropine; Cholinesterase Inhibitors; Guinea Pigs; Muscle Contraction; Muscle | 1963 |
EFFECTS OF SURFACTANTS ON THE TWITCH TENSION OF FROG SARTORIUS MUSCLE.
Topics: Acetylcholine; Ammonium Compounds; Animals; Anti-Infective Agents, Local; Anura; Cathartics; Curare; | 1964 |
INTESTINAL MOTILITY IN MAN. II. THE BEHAVIOR OF THE SMALL INTESTINE FOLLOWING PARTIAL GASTRECTOMY WITH PARTICULAR REFERENCE TO THE DUMPING SYNDROME.
Topics: Cineradiography; Digestion; Dumping Syndrome; Gastrectomy; Gastroenterostomy; Gastrointestinal Motil | 1965 |
INTESTINAL MOTILITY IN MAN. I. A STUDY COMBINING THE USE OF INTRALUMINAL PRESSURE RECORDING AND CINERADIOGRAPHY.
Topics: Cineradiography; Digestion; Emotions; Gastrointestinal Motility; Humans; Intestine, Large; Intestine | 1965 |
INTESTINAL MOTILITY IN MAN. 3. MECHANISMS OF CONSTIPATION AND DIARRHEA WITH PARTICULAR REFERENCE TO THE IRRITABLE COLON SYNDROME.
Topics: Colitis; Colitis, Ulcerative; Colon; Colonic Diseases, Functional; Constipation; Diarrhea; Digestion | 1965 |
RESPONSES OF THE RAT URINARY BLADDER IN SITU TO DRUGS AND TO NERVE STIMULATION.
Topics: Acetylcholine; Atropine; Epinephrine; Ganglionic Blockers; Histamine; Injections, Intravenous; Methy | 1965 |
THE ACTION OF PEMPIDINE AND ANTIADRENALINE SUBSTANCES AT THE SYMPATHETIC POSTGANGLIONIC TERMINATION.
Topics: Abdominal Wall; Acetylcholine; Animals; Anura; Cholinesterase Inhibitors; Dihydroergotoxine; Electro | 1965 |
Interactions of edrophonium with neostigmine in the rat trachea.
Topics: Animals; Drug Interactions; Edrophonium; In Vitro Techniques; Inosine Triphosphate; Male; Muscle Con | 2003 |
Inhibition of guinea pig intestinal peristalsis by the flavonoids quercetin, naringenin, apigenin and genistein.
Topics: Animals; Antidiarrheals; Apamin; Apigenin; Ceruletide; Dimethylphenylpiperazinium Iodide; Dose-Respo | 2004 |
In vitro neuromuscular activity of 'colubrid' venoms: clinical and evolutionary implications.
Topics: Analysis of Variance; Animals; Chickens; Muscle Contraction; Neostigmine; Neuromuscular Agents; Neur | 2004 |
The role of tension receptors in colonic mechanosensitivity in humans.
Topics: Adult; Cholinesterase Inhibitors; Colon; Dilatation; Female; Humans; Male; Manometry; Mechanorecepto | 2004 |
Reactivity of urinary bladder smooth muscle in guinea pigs to acetylcholine and carbachol--participation of acetylcholinesterase.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Carbachol; Cholinesterase Inhibitors; Guinea Pigs; In | 2005 |
Contractile response to colonic distention is influenced by oscillation frequency.
Topics: Acetylcholine; Adult; Catheterization; Cholinesterase Inhibitors; Colon; Elasticity; Female; Humans; | 2005 |
Neural regulation of slow-wave frequency in the murine gastric antrum.
Topics: Acetylcholine; Androstenes; Animals; Atropine; Benzamides; Benzimidazoles; Carbachol; Electric Stimu | 2006 |
Cholinergic innervation of the mouse isolated vas deferens.
Topics: Acetylcholine; Animals; Atropine; Bretylium Compounds; Cyclopentolate; Male; Mice; Mice, Inbred BALB | 2005 |
Neostigmine, but not metoclopramide, abolishes ethosuximide-induced functional gastrointestinal disturbances.
Topics: Animals; Anticonvulsants; Cholinesterase Inhibitors; Dopamine Antagonists; Dose-Response Relationshi | 2005 |
Isolation and characterization of rufoxin, a novel protein exhibiting neurotoxicity from venom of the psammophiine, Rhamphiophis oxyrhynchus (Rufous beaked snake).
Topics: Analysis of Variance; Animals; Chickens; Cholinesterase Inhibitors; Chromatography, High Pressure Li | 2007 |
Cholinergic innervation of the guinea-pig isolated vas deferens.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Bretylium Compounds; Calcium; Cholinesterase I | 2007 |
Reinnervation of smooth and striated muscle by sensory nerve fibers.
Topics: Animals; Atropine; Cats; Electric Stimulation; Follow-Up Studies; Muscle Contraction; Muscle, Smooth | 1967 |
Evaluation of muscle relaxants in post-tetanic fibrillation of the dog.
Topics: Animals; Aspirin; Chlormezanone; Dogs; Electric Stimulation; Female; Glycols; Isotonic Solutions; Ma | 1967 |
pPy: a measure of potentiating activity.
Topics: Acetylcholine; Animals; Anura; Cholinesterase Inhibitors; Curare; Edrophonium; Isoflurophate; Muscle | 1967 |
In vivo contractility of smooth muscle by cholecystokinin concentrates.
Topics: Animals; Atropine; Blood Pressure; Cholecystokinin; Colon; Dogs; Female; Gallbladder; Insulin; Kymog | 1967 |
Effects of injection of tetraethylammonium into the rachis.
Topics: Animals; Anura; Blood Glucose; Central Nervous System; Dogs; Electromyography; Injections, Spinal; M | 1967 |
Membrane potential and tension in guinea-pig ureter.
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Calcium; Dibenzylchlorethamine; Dinitrophenols; | 1967 |
Mechanisms of substance P-induced contraction of rabbit airway smooth muscle.
Topics: Animals; Atropine; Biomechanical Phenomena; Dose-Response Relationship, Drug; Ganglia, Parasympathet | 1984 |
Potentiation between neostigmine and 3,4-diaminopyridine in antagonizing the neuromuscular block induced by D-tubocurarine.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Drug Synergism; Female; Male; Mice; Muscle | 1984 |
Clinical pharmacology of ORG NC45 (NorcuronTM): a new nondepolarizing muscle relaxant.
Topics: Adult; Aged; Anesthesia, Inhalation; Halothane; Humans; Middle Aged; Muscle Contraction; Neostigmine | 1981 |
Contractile effect of prolactin on guinea pig isolated ileum.
Topics: Acetylcholine; Animals; Atropine; Dibenz(b,f)(1,4)oxazepine-10(11H)-carboxylic acid, 8-chloro-, 2-ac | 1981 |
Some actions of Org NC 45 and of edrophonium in the anaesthetized cat and in man.
Topics: Adult; Aged; Anesthesia, General; Animals; Cats; Edrophonium; Female; Humans; Male; Middle Aged; Mus | 1982 |
Effect of cocaine on tone and contractile responses to acetylcholine in the rat anococcygeus muscle.
Topics: Acetylcholine; Animals; Atropine; Cocaine; Desipramine; Drug Interactions; Male; Muscle Contraction; | 1982 |
[The excitation effect of pachycarpine on skeletal muscles].
Topics: Animals; Cats; Female; Ganglionic Blockers; In Vitro Techniques; Male; Mice; Muscle Contraction; Neo | 1982 |
Clinical evaluation of Org NC 45.
Topics: Adult; Drug Evaluation; Humans; Intubation, Intratracheal; Muscle Contraction; Neostigmine; Neuromus | 1983 |
Acetylcholine and an unidentified, muscle-contracting factor in the venom of the bumblebee, Bombus terrestris L.
Topics: Acetylcholine; Animals; Bee Venoms; Female; Guinea Pigs; In Vitro Techniques; Muscle Contraction; Mu | 1983 |
A pharmacological and ultrastructural study of the rabbit gubernaculum testis.
Topics: Acetylcholine; Animals; Atropine; Electric Stimulation; Male; Microscopy, Electron; Muscle Contracti | 1983 |
Comparison of vecuronium, atracurium and tubocurarine in normal patients and in patients with no renal function.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Atracurium; Blood Pressure; Female; Heart Rate; Humans | 1984 |
Reversal of combination nondepolarized neuromuscular block.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Electric Stimulation; Humans; Middle Aged; Muscle Cont | 1983 |
Twitch depression and train-of-four ratio after antagonism of pancuronium with edrophonium, neostigmine, or pyridostigmine.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Edrophonium; Electric Stimulation; Humans; Middle Aged | 1983 |
The neuromuscular pharmacology of neostigmine in infants and children.
Topics: Adult; Anesthesia, Inhalation; Child; Child, Preschool; Dose-Response Relationship, Drug; Humans; In | 1983 |
Neostigmine and edrophonium as antagonists of pancuronium in infants and children.
Topics: Anesthesia; Child; Child, Preschool; Edrophonium; Humans; Infant; Infant, Newborn; Muscle Contractio | 1983 |
The effects of iprindole on noradrenergic transmission in the rat anococcygeus muscle.
Topics: Animals; Electric Stimulation; In Vitro Techniques; Indoles; Iprindole; Male; Muscle Contraction; Mu | 1983 |
Neostigmine antagonism of succinylcholine phase II block: a comparison with pancuronium.
Topics: Adult; Female; Humans; Male; Middle Aged; Muscle Contraction; Neostigmine; Neuromuscular Junction; P | 1983 |
Correlation between anticurare activity of tetanic stimulation and neostigmine in anesthetized man.
Topics: Adolescent; Adult; Aged; Electric Stimulation; Female; Humans; Male; Middle Aged; Muscle Contraction | 1981 |
Blocking effects of a new component, paeoniflorigenone, in paeony root on neuromuscular junctions of frogs and mice.
Topics: Acetylcholine; Animals; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Monoterpenes; Muscle | 1984 |
Effect of sodium propionate on the contractile response of the rat ileum in situ.
Topics: Animals; Atropine; Blood Pressure; Fatty Acids; Gastrointestinal Motility; Heart Rate; Hexamethonium | 1984 |
Muscle electromechanical correlations during succinylcholine infusion.
Topics: Adult; Anesthesia, General; Electric Stimulation; Electromyography; Humans; Infusions, Parenteral; M | 1984 |
Antagonism of pancuronium neuromuscular blockade in halothane-anesthetized ponies using neostigmine and edrophonium.
Topics: Anesthesia, General; Animals; Blood Pressure; Cardiovascular System; Digestive System; Edrophonium; | 1984 |
[Effects of trimebutine and metoclopramide on colonic motility in the guinea pig].
Topics: Animals; Benzoates; Colon; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Mot | 1984 |
Infusion of atracurium for long surgical procedures.
Topics: Adult; Aged; Atracurium; Atropine; Humans; Infusions, Parenteral; Intraoperative Period; Isoquinolin | 1984 |
Assessment of neuromuscular blockade using tetanic, single-twitch and train-of-four responses: discussion paper.
Topics: Anesthesia; Atracurium; Gallamine Triethiodide; Humans; Isoquinolines; Monitoring, Physiologic; Musc | 1984 |
[Antagonistic effects of neostigmine, 4-aminopyridine and 3,4-diaminopyridine on muscle relaxing effects of d-tubocurarine].
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Muscle Contraction; Muscle Relaxation; Neos | 1983 |
Monitoring neuromuscular blockade--evaluation of a new rectal electrode/transducer system in cats.
Topics: Alcuronium; Anal Canal; Anesthesia; Animals; Atropine; Cats; Monitoring, Physiologic; Muscle Contrac | 1984 |
Myoneural effects of pethidine and droperidol.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Droperidol; Drug Interactions; Electric Stimulation; In Vi | 1984 |
Can 4-aminopyridine be used to reverse anaesthesia and muscle relaxation?
Topics: 4-Aminopyridine; Adolescent; Adult; Aminopyridines; Anesthetics; Drug Evaluation; Electrocardiograph | 1983 |
Effect of protein synthesis inhibitors on the trophic action of the nerve stump.
Topics: Acetylcholine; Animals; Chloramphenicol; Cycloheximide; Dactinomycin; Dose-Response Relationship, Dr | 1983 |
[Experimental investigation on hypersensitivity of canine airways--effect of various drugs on bronchoconstriction induced by vagosympathetic nerve stimulation].
Topics: Animals; Bronchi; Dogs; Electric Stimulation; Isoproterenol; Muscle Contraction; Muscle, Smooth; Neo | 1983 |
Mechanical responses to peroneal nerve stimulation in halothane-anesthetized horses in the absence of neuromuscular blockade and during partial nondepolarizing blockade.
Topics: Anesthesia; Animals; Cats; Edrophonium; Electric Stimulation; Gallamine Triethiodide; Halothane; Hor | 1983 |
Cumulative dose responses to gallamine, pancuronium, and neostigmine in halothane-anesthetized horses: neuromuscular and cardiovascular effects.
Topics: Anesthesia; Animals; Dose-Response Relationship, Drug; Electric Stimulation; Female; Gallamine Triet | 1983 |
Mechanisms of histamine-induced contraction of canine airway smooth muscle.
Topics: Acetylcholine; Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Histamine; Muscle Contract | 1983 |
Effect of antimuscarinic agents on the contractile responses to cholinomimetics in the rat anococcygeus muscle.
Topics: Animals; Atropine; Carbachol; Hexamethonium Compounds; In Vitro Techniques; Male; Methacholine Compo | 1981 |
Tachyphylaxis after repeated dosage of decamethonium in anaesthetized man.
Topics: Anesthesia; Decamethonium Compounds; Halothane; Humans; Muscle Contraction; Neostigmine; Tachyphylax | 1982 |
[Comparative responses of various parts of the tracheo-bronchial tree to bronchoactive agents (author's transl)].
Topics: Acetylcholine; Animals; Bronchi; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Neostig | 1982 |
Neostigmine reversal of D-tubocurarine and pancuronium bromide combinations in man.
Topics: Adult; Anesthesia; Female; Humans; Male; Muscle Contraction; Neostigmine; Pancuronium; Time Factors; | 1982 |
A pharmacological comparison of organophosphorus and carbamate anti-cholinesterase agents on guinea pig ileum.
Topics: Animals; Carbamates; Cholinesterase Inhibitors; Guinea Pigs; Ileum; In Vitro Techniques; Isofluropha | 1982 |
Effects of acetylcholine on the tone and miniature contractions of isolated dog urinary bladder.
Topics: Acetylcholine; Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Female; Hexamethonium Comp | 1982 |
Edrophonium: duration of action and atropine requirement in humans during halothane anesthesia.
Topics: Anesthesia, General; Arrhythmias, Cardiac; Atropine; Blood Pressure; Dose-Response Relationship, Dru | 1982 |
Effects on muscle of a toxin from Indian cobra (Naja naja naja) venom.
Topics: Acetylcholine; Animals; Calcium; Dose-Response Relationship, Drug; Elapid Venoms; In Vitro Technique | 1982 |
Use of atracurium during general surgery monitored by the train-of-four stimuli.
Topics: Adult; Aged; Atracurium; Electric Stimulation; Female; Humans; Isoquinolines; Male; Middle Aged; Mon | 1982 |
Use of atracurium in patients with no renal function.
Topics: Adult; Atracurium; Electric Stimulation; Female; Humans; Isoquinolines; Kidney Failure, Chronic; Mal | 1982 |
Antagonism of Org NC 45 neuromuscular blockade by neostigmine, pyridostigmine, and 4-aminopyridine.
Topics: Aminopyridines; Animals; Dose-Response Relationship, Drug; Muscle Contraction; Neostigmine; Neuromus | 1980 |
Posttetanic facilitation as index for antagonism of phase II block of succinylcholine in patients with atypical cholinesterase.
Topics: Cholinesterases; Humans; Muscle Contraction; Neostigmine; Succinylcholine | 1981 |
Paralytic properties of 4-N, N-dimethylamino-1,2-dithiolane (nereistoxin).
Topics: Acetylcholine; Animals; Dogs; Hemodynamics; Marine Toxins; Muscle Contraction; Neostigmine; Paralysi | 1980 |
Synthesis and preliminary pharmacology of an internal standard for assay of neostigmine.
Topics: Acetylcholine; Alkylation; Animals; Brain Chemistry; Choline; Chromatography, Gas; In Vitro Techniqu | 1981 |
Neuromuscular blocking properties of dioxonium.
Topics: Adult; Dioxolanes; Dioxoles; Electric Stimulation; Electromyography; Humans; Middle Aged; Muscle Con | 1980 |
Peripheral versus central action of a toxin from Indian cobra (Naja naja Naja) venom.
Topics: Action Potentials; Animals; Blood Pressure; Cats; Elapid Venoms; Electrocardiography; Heart Rate; In | 1981 |
Morphine: a dual effect at the canine choledochoduodenal junction.
Topics: Animals; Atropine; Bile; Common Bile Duct; Dogs; Dose-Response Relationship, Drug; Duodenum; Female; | 1981 |
Actions of chloroquine and its N-oxidation metabolites on the rectus abdominis muscle of the toad (Bufo regularis).
Topics: Acetylcholine; Animals; Biotransformation; Bufonidae; Carbachol; Chloroquine; Cyclic N-Oxides; In Vi | 1981 |
Cholinergic component of the excitatory response in the rat anococcygeus muscle.
Topics: Acetylcholine; Animals; Atropine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contractio | 1981 |
Canine gastric sling fibers: contractile properties.
Topics: Acetylcholine; Animals; Atropine; Dogs; Esophagogastric Junction; Female; Isoproterenol; Male; Muscl | 1980 |
Neuromuscular blockade by neostigmine in anaesthetized man.
Topics: Anesthesia, General; Drug Interactions; Drug Synergism; Gallamine Triethiodide; Halothane; Humans; M | 1980 |
An extension of pA principle to the potentiation of drug effects, and its application to the biological assay of some anticholinesterases and cardenolides.
Topics: Animals; Anura; Biological Assay; Cardenolides; Cholinesterase Inhibitors; Dose-Response Relationshi | 1980 |
The gastric motility patterns induced by direct and reflex excitation of the vagus nerves in the anaesthetized ferret.
Topics: Animals; Atropine; Carnivora; Deoxyglucose; Female; Ferrets; Gastrointestinal Motility; Hexamethoniu | 1980 |
Reversal of dantrolene sodium-induced depression of skeletal muscle in the cat.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcium Chloride; Cats; Cevanes; Dantrolene; Electromyogra | 1981 |
The effect of neostigmine on twitch tension and muscle relaxant concentration during infusion of mivacurium or vecuronium.
Topics: Adolescent; Adult; Humans; Isoquinolines; Middle Aged; Mivacurium; Muscle Contraction; Neostigmine; | 1995 |
Binding and biologic activity of neurotensin in guinea pig ileum.
Topics: Adenine Nucleotides; Amino Acid Sequence; Animals; Atropine; Biphenyl Compounds; Cell Membrane; Dose | 1994 |
beta-Eudesmol as an antidote for intoxication from organophosphorus anticholinesterase agents.
Topics: Animals; Anti-Ulcer Agents; Antidotes; Atropine; Cholinesterase Inhibitors; Electrophysiology; Femal | 1995 |
Reversal of residual neuromuscular block with neostigmine at one to four hours after a single intubating dose of vecuronium.
Topics: Adult; Anesthesia; Female; Humans; Male; Middle Aged; Muscle Contraction; Neostigmine; Neuromuscular | 1995 |
Inadequate antagonism of vecuronium-induced neuromuscular block by neostigmine during sevoflurane or isoflurane anesthesia.
Topics: Adult; Anesthesia; Anesthetics; Dose-Response Relationship, Drug; Ethers; Female; Humans; Isoflurane | 1995 |
Postsynaptic nicotinic receptor desensitized by non-contractile Ca2+ mobilization via protein kinase-C activation at the mouse neuromuscular junction.
Topics: Alkaloids; Animals; Calcium; Diaphragm; Electric Stimulation; Enzyme Activation; In Vitro Techniques | 1995 |
Postoperative recurrent paralysis in an infant after mivacurium infusion.
Topics: Female; Humans; Infant; Infusions, Intravenous; Isoquinolines; Mivacurium; Muscle Contraction; Neost | 1994 |
Early and late reversibility of rocuronium bromide.
Topics: Androstanols; Computer Simulation; Humans; Muscle Contraction; Neostigmine; Neuromuscular Nondepolar | 1994 |
Non-adrenergic non-cholinergic (NANC) excitatory response of the channel catfish intestine.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine; Autonom | 1994 |
Neuromuscular effects of vecuronium and neostigmine in Montreal and Paris.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous | 1994 |
Pharmacological relevance of peripheral type benzodiazepine receptors on motor nerve and skeletal muscle.
Topics: Animals; Benzodiazepinones; Diaphragm; Electric Stimulation; Electrophysiology; Female; Flumazenil; | 1994 |
Transmitter-mediated local contracture of the endplate region of the focally innervated mouse diaphragm treated with anticholinesterase.
Topics: Action Potentials; Animals; Calcium; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; For | 1993 |
Effects of cholinesterase inhibitors on the neuromuscular blocking action of suxamethonium.
Topics: Animals; Cholinesterase Inhibitors; Drug Interactions; Edrophonium; Hindlimb; Male; Muscle Contracti | 1994 |
Effects of chlorhexidine on the isolated rat phrenic nerve-diaphragm preparation.
Topics: Animals; Chlorhexidine; Decamethonium Compounds; Diaphragm; Electromyography; Female; Hydroxymercuri | 1994 |
Effect of diazepam on muscle weakness in a model of myasthenia gravis in rats.
Topics: Animals; Bungarotoxins; Diazepam; Disease Models, Animal; Female; Lip; Male; Muscle Contraction; Mus | 1993 |
Different mode of action of endothelin-1 in parietal and visceral veins.
Topics: Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Endothelins; In Vitro Techniques; Jugular | 1993 |
Improvement by diazepam of neuromuscular transmission blocked by anticholinesterase agents in mouse diaphragms.
Topics: Animals; Cholinesterase Inhibitors; Diaphragm; Diazepam; Female; In Vitro Techniques; Male; Membrane | 1993 |
Vasoactive intestinal polypeptide causes relaxation of the pyloric sphincter in the rabbit.
Topics: Animals; Dose-Response Relationship, Drug; Hypertrophy; Muscle Contraction; Neostigmine; Pyloric Ste | 1993 |
Atracurium after an anticholinesterase. Does prior reversal with edrophonium or neostigmine influence the response to atracurium?
Topics: Adult; Atracurium; Edrophonium; Female; Humans; Male; Muscle Contraction; Neostigmine; Neuromuscular | 1993 |
Chronic denervation of rat jejunum results in cholinergic supersensitivity due to reduction of cholinesterase activity.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinergic Fibers; Cholinesterases; Drug Interactions | 1993 |
Mivacurium-induced neuromuscular blockade in patients with atypical plasma cholinesterase.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Cholinesterases; Heterozygote; Homozygote; Huma | 1993 |
Prolonged paralysis after long-term, high-dose infusion of pancuronium in anaesthetized cats.
Topics: 4-Aminopyridine; Animals; Cats; Hemodynamics; Infusions, Intravenous; Male; Muscle Contraction; Neos | 1993 |
Degradation of acetylcholine in human airways: role of butyrylcholinesterase.
Topics: Acetylcholine; Acetylcholinesterase; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2 | 1993 |
Synthesis of 2-imidazolidinylidenepropanedinitrile derivatives as stimulators of gastrointestinal motility.
Topics: Animals; Cholinesterase Inhibitors; Electric Stimulation; Gastrointestinal Motility; Guinea Pigs; Il | 1993 |
Dual action of ranitidine at cholinergic sites in the rat isolated anococcygeus muscle.
Topics: Acetylcholine; Animals; Carbachol; Cholinergic Fibers; Dose-Response Relationship, Drug; Drug Intera | 1993 |
Effect of neostigmine at different levels of mivacurium-induced neuromuscular blockade.
Topics: Adolescent; Adult; Aged; Anesthetics, Inhalation; Anesthetics, Intravenous; Cholinesterase Inhibitor | 1995 |
Anticholinesterase drugs stimulate phosphatidylinositol response in rat tracheal slices.
Topics: Animals; Cholinesterase Inhibitors; Male; Muscle Contraction; Muscle, Smooth; Neostigmine; Phosphati | 1996 |
Pharmacodynamic dose-response and safety study of cisatracurium (51W89) in adult surgical patients during N2O-O2-opioid anesthesia.
Topics: Adolescent; Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Anesthetics, Inhalation; A | 1996 |
Platelet-activating factor (PAF) stimulates giant migrating contractions during ileal inflammation.
Topics: Animals; Calcium; Dogs; Female; Ileitis; Ileum; Male; Methacholine Chloride; Motilin; Muscle Contrac | 1996 |
Pharmacodynamic analysis of contractile potentiation by cholinesterase inhibitors in rats.
Topics: Ambenonium Chloride; Animals; Cattle; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; E | 1996 |
Actions of beta-endorphin peptides on the contractions of mouse diaphragm muscle.
Topics: Animals; Benzylidene Compounds; beta-Endorphin; Diaphragm; Dipeptides; Electric Stimulation; Enkepha | 1997 |
[Effect of shashen maidong decoction on gastric motility in vivo].
Topics: Animals; Drugs, Chinese Herbal; Female; Gastric Emptying; Gastrointestinal Agents; Gastrointestinal | 1996 |
Neuromuscular blocking actions of the aminoglycoside antibiotics sisomicin and micronomicin in the rabbit.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium; Dose-Response Relationship, Drug; Gentamic | 1997 |
The in vivo effect of lipopolysaccharide on neuromuscular transmission in the mouse.
Topics: Animals; Anti-Bacterial Agents; Diaphragm; Enzyme Inhibitors; Lipopolysaccharides; Mice; Motor Neuro | 1997 |
Enhanced alpha2A-autoreceptor reserve for clonidine induced by reserpine and cholinomimetic agents in the rat vas deferens.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Clonidine; Dose-Res | 1997 |
[Contractile activity of smooth muscle of the duodenum during duodenal ulcer and its treatment with metacine and proserine].
Topics: Animals; Benzilates; Choline; Cholinergic Antagonists; Cholinesterase Inhibitors; Drug Therapy, Comb | 1997 |
Antagonism of atracurium-induced block in obese patients.
Topics: Adult; Anesthetics, Inhalation; Anesthetics, Intravenous; Atracurium; Body Mass Index; Body Weight; | 1998 |
Recycling of acetylcholine following impulse transmission in rat muscle revealed in the presence of neostigmine.
Topics: Acetylcholine; Animals; Electric Stimulation; Evoked Potentials; Muscle Contraction; Muscle, Skeleta | 1998 |
Characterization of neural control and contractile function in airway smooth muscle of the ferret.
Topics: Acetylcholine; Adrenergic Agonists; Animals; Bronchoconstriction; Bronchoconstrictor Agents; Carbach | 1998 |
Sepsis attenuates the intensity of the neuromuscular blocking effect of d-tubocurarine and the antagonistic actions of neostigmine and edrophonium accompanying depression of muscle contractility of the diaphragm.
Topics: Animals; Cholinesterase Inhibitors; Diaphragm; Dose-Response Relationship, Drug; Edrophonium; In Vit | 1999 |
Anaphylactic bronchoconstriction in BP2 mice: interactions between serotonin and acetylcholine.
Topics: Acetylcholine; Anaphylaxis; Animals; Atropine; Bronchoconstriction; Bronchodilator Agents; Cholinest | 1999 |
Contractile and phosphatidylinositol responses of rat trachea to anticholinesterase drugs.
Topics: Animals; Carbachol; Cholinergic Agonists; Cholinesterase Inhibitors; Dimethylphenylpiperazinium Iodi | 1998 |
Spinal cholinergic inhibition of the pressor response to skeletal muscle activation.
Topics: Analysis of Variance; Animals; Atropine; Blood Pressure; Cats; Heart Rate; Microdialysis; Muscle Con | 1999 |
Factors predicting atracurium reversal time.
Topics: Adult; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Atracurium; Ch | 1999 |
Neuromuscular blocking effects of an alkaloidal extract from Inula royleana: contractile and electrical studies on amphibian skeletal muscle in vitro.
Topics: Action Potentials; Alkaloids; Animals; Electric Stimulation; Electrophysiology; In Vitro Techniques; | 2000 |
Muscarinic receptor knockout mice: role of muscarinic acetylcholine receptors M(2), M(3), and M(4) in carbamylcholine-induced gallbladder contractility.
Topics: Animals; Anti-Arrhythmia Agents; Atropine; Carbachol; Cardiovascular Agents; Cholinesterase Inhibito | 2002 |
Twitch potentiation of skeletal muscle by physostigmine at different pH.
Topics: Action Potentials; Animals; Hydrogen-Ion Concentration; In Vitro Techniques; Isoflurophate; Muscle C | 1976 |
Comparative evaluation of neuromuscular blockade and reversibility of AH 8165 and pancuronium bromide in man.
Topics: Adult; Aged; Humans; Middle Aged; Muscle Contraction; Neostigmine; Neuromuscular Blocking Agents; Ne | 1976 |
Potentiation of neostigmine and pyridostigmine by 4-aminopyridine in the rat.
Topics: Aminopyridines; Animals; Drug Synergism; Muscle Contraction; Neostigmine; Pancuronium; Pyridostigmin | 1978 |
Effect of strophantin on the isolated guinea-pig ileum.
Topics: Animals; Calcium; Drug Interactions; Female; Ganglionic Blockers; Guinea Pigs; Ileum; In Vitro Techn | 1979 |
Muscular dystrophy contrasted with denervation: different mechanisms underlying spontaneous fibrillations.
Topics: Acetylcholine; Animals; Cell Membrane; Electromyography; Haplorhini; Humans; Membrane Potentials; Mo | 1978 |
A hypothesis to account for the Mary Walker phenomenon.
Topics: Acetylcholine; Action Potentials; Electric Stimulation; Evoked Potentials; Forearm; History, 20th Ce | 1975 |
[Pharmacological analysis of the inhibition of peristalsis of the isolated guinea-pig ileum by tetramethylammonium].
Topics: Acetylcholine; Animals; Arecoline; Carbachol; Female; Gastrointestinal Motility; Guinea Pigs; Histam | 1976 |
[Pharmacological analysis of the pendular movements appearing during calcium blocking of peristalsis in the isolated guinea pig ileum].
Topics: Animals; Atropine; Calcium; Gastrointestinal Motility; Guinea Pigs; Hexamethonium Compounds; Ileum; | 1977 |
[Pharmacological analysis of the peristalsis block induced by magnesium applied at the serosal and mucosal surfaces of the isolated guinea pig ileum].
Topics: Acetylcholine; Animals; Choline; Female; Gastrointestinal Motility; Guinea Pigs; Histamine; Ileum; I | 1977 |
Interaction of halothane with non-depolarizing neuromuscular blocking drugs in man.
Topics: Anesthesia; Atropine; Drug Interactions; Gallamine Triethiodide; Halothane; Humans; Muscle Contracti | 1979 |
The generation of nerve and muscle repetivie activity in the rat phrenic nerve-diaphragm preparation following inhibition of cholinesterase by ecothiopate.
Topics: Acetylcholine; Action Potentials; Ambenonium Chloride; Animals; Diaphragm; Drug Interactions; Echoth | 1977 |
A study of excitatory neuromuscular transmission in the bovine trachea.
Topics: Acetylcholine; Animals; Atropine; Axons; Cattle; In Vitro Techniques; Membrane Potentials; Muscle Co | 1977 |
Neostigmine-induced alterations at the mammalian neuromuscular junction. I. Muscle contraction and electrophysiology.
Topics: Acetylcholine; Animals; Drug Interactions; Female; In Vitro Techniques; Membrane Potentials; Membran | 1978 |
Antibiotic-induced paralysis of the mouse phrenic nerve-hemidiaphragm preparation, and reversibility by calcium and by neostigmine.
Topics: Animals; Anti-Bacterial Agents; Calcium; Diaphragm; Humans; Magnesium; Mice; Muscle Contraction; Neo | 1978 |
[Effects of selective applications of drugs affecting ganglionic transmission to the hypogastric ganglion of the guinea pig (author's transl)].
Topics: Acetylcholine; Animals; Dimethylphenylpiperazinium Iodide; Ganglia, Autonomic; Guinea Pigs; Hemichol | 1978 |
Myasthenia in patients with dermatomyositis: clinical, electrophysiological and ultrastructural studies.
Topics: Adolescent; Adult; Biopsy; Dermatomyositis; Electromyography; Evoked Potentials; Fatigue; Female; Gl | 1978 |
Innervation of the canine inferior vena cava. Distribution of adrenergic and cholinergic excitatory fibers among the embryologically distinct segments.
Topics: Acetylcholine; Adrenergic Fibers; Animals; Atropine; Cholinergic Fibers; Dogs; Electric Stimulation; | 1979 |
Cyclic nucleotides and neuromuscular transmission.
Topics: Adenylyl Cyclases; Animals; Axons; Bucladesine; Cats; Cyclic AMP; Epinephrine; Muscle Contraction; M | 1979 |
The relationship between the pharmacokinetics, cholinesterase inhibition and facilitation of twitch tension of the quaternary ammonium anticholinesterase drugs, neostigmine, pyridostigmine, edrophonium and 3-hydroxyphenyltrimethylammonium.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Edrophonium; Erythrocytes; Half-Life; Kine | 1979 |
Corticosteroids and neuromuscular transmission: electrophysiological investigation of the effects of prednisolone on normal and anticholinesterase-treated neuromuscular junction.
Topics: Animals; Dose-Response Relationship, Drug; Drug Interactions; In Vitro Techniques; Male; Muscle Cont | 1979 |
Ephedrine and neuromuscular transmission, in vivo.
Topics: Aminophylline; Animals; Cats; Drug Interactions; Ephedrine; Female; Male; Muscle Contraction; Neosti | 1979 |
The effect of acid-base balance on neostigmine antagonism of d-tubocurarine-induced neuromuscular blockade.
Topics: Acid-Base Equilibrium; Acidosis; Acidosis, Respiratory; Alkalosis; Alkalosis, Respiratory; Anesthesi | 1975 |
Excitatory actions of GABA and of acetyl-choline in sea urchin tube feet.
Topics: Acetylcholine; Aminobutyrates; Atropine; Butyrylthiocholine; Carbachol; Chlorides; Decamethonium Com | 1975 |
Relaxation experiments using bath-applied suberyldicholine.
Topics: Animals; Anura; Bungarotoxins; Choline; Dicarboxylic Acids; Dose-Response Relationship, Drug; Electr | 1977 |
Rate of heat production related to degree of filament overlap in chick ALD muscle.
Topics: Animals; Back; Chickens; Energy Metabolism; Female; Hot Temperature; Male; Muscle Contraction; Muscl | 1977 |
Effects of certain muscarinic antagonists on the actions of anticholinesterases on cat skeletal muscle.
Topics: Acetylcholinesterase; Animals; Cats; Cholinesterase Inhibitors; Drug Interactions; Female; In Vitro | 1979 |
Effects of adrenergic and cholinergic agents on ureteral functions in dogs.
Topics: Animals; Atropine; Dogs; Dose-Response Relationship, Drug; Female; Furosemide; Male; Metaproterenol; | 1979 |
Neurotensin contracts the guinea-pig longitudinal ileal smooth muscle by inducing acetylcholine release.
Topics: Acetylcholine; Animals; Atropine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; | 1979 |
Electrical and mechanical activity in the ex vivo perfused total canine colon.
Topics: Animals; Colon; Dogs; Electrophysiology; Fourier Analysis; Gastrointestinal Motility; Muscle Contrac | 1979 |
An effect of neostigmine on the response of the rat anococcygeus muscle to field stimulation [proceedings].
Topics: Animals; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Neostigmine; Rats | 1979 |
Activation of satellite cells induced by chronic neostigmine administration in the rat.
Topics: Animals; Cell Fusion; Male; Muscle Contraction; Muscles; Myofibrils; Neostigmine; Rats | 1979 |
[Some pharmacologic actions of the dahurisoline methyl bromide, a preliminary report (author's transl)].
Topics: Alkaloids; Animals; Calcium Gluconate; Cats; Female; Isoquinolines; Male; Mice; Muscle Contraction; | 1979 |
[An experimental study on transduodenal sphincteroplasty (author's transl)].
Topics: Action Potentials; Ampulla of Vater; Animals; Bile Ducts; Duodenum; Methods; Muscle Contraction; Mus | 1977 |
Pharmacological properties of curare-sensitive receptors mediating post-tetanic potentiation in rat masseter muscle.
Topics: Animals; Atropine; Curare; Electric Stimulation; Hexamethonium Compounds; Lidocaine; Male; Motor End | 1978 |
Oxotremorine neuromuscular blockade: effects of calcium and neostigmine and interactions with D-tubocurarine and decamethonium.
Topics: Animals; Calcium; Decamethonium Compounds; Diaphragm; Drug Interactions; Electric Stimulation; In Vi | 1978 |
[Effect of puromycin, nalidixic acid and cycloheximide on neuromuscular transmission].
Topics: Animals; Calcium; Cycloheximide; Diaphragm; Electric Stimulation; Electromyography; Muscle Contracti | 1975 |
Gastrointestinal myoelectrical activity in idiopathic intestinal pseudo-obstruction.
Topics: Adult; Anal Canal; Chronic Disease; Colon; Diagnosis, Differential; Duodenum; Electromyography; Esop | 1977 |
Ligated renal pedicles and duration of action of neostigmine and pyridostigmine.
Topics: Animals; Cats; In Vitro Techniques; Kidney; Ligation; Muscle Contraction; Neostigmine; Pyridostigmin | 1977 |
Adrenergic and cholinergic stimulation and blockade of the human bladder base.
Topics: Acetylcholine; Autonomic Nervous System; Binding Sites; Humans; In Vitro Techniques; Muscle Contract | 1976 |
[Pseudoparalytic myasthenia gravis. Diagnostic and therapeutic aspects in 60 separate cases].
Topics: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Diagnosis, Differential; Edrophonium; | 1976 |
Electrical spike potentials of the small bowel: a comparative study of recordings obtained from muscular implanted and intraluminal suction electrodes.
Topics: Action Potentials; Animals; Dogs; Duodenum; Electrodes; Electrodes, Implanted; Electrophysiology; Ga | 1976 |
Studies on the uptake of 14C-neostigmine in the isolated rat diaphragm.
Topics: Animals; Diaphragm; Female; In Vitro Techniques; Muscle Contraction; Muscles; Neostigmine; Nitrogen; | 1976 |
A comparison of the effect of cholinesterase inhibitors on end-plate current and on cholinesterase activity in frog muscle.
Topics: Animals; Anura; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromid | 1975 |
Neuromuscular failure in myotonic rats.
Topics: Animals; Cholesterol; Depression, Chemical; Electric Stimulation; Evoked Potentials; Male; Median Ne | 1975 |
Potentiation of suxamethonium blockade by neostigmine in patients with atypical cholinesterase.
Topics: Anesthesia, Inhalation; Atropine; Child; Cholinesterases; Drug Synergism; Electric Stimulation; Halo | 1975 |
Blockade of acetylcholine receptors: a model of myasthenia gravis.
Topics: Action Potentials; Animals; Curare; Disease Models, Animal; Electric Stimulation; Evoked Potentials; | 1975 |
Myasthenia gravis with features of the myasthenic syndrome. An investigation with electrophysiologic methods including single-fiber electromyography.
Topics: Action Potentials; Drug Therapy, Combination; Edrophonium; Electric Stimulation; Electromyography; F | 1975 |
Effects of atropine and neostigmine on receptor interaction at the neuromuscular junction.
Topics: Animals; Atropine; Cholinesterases; Denervation; Diaphragm; Drug Interactions; Electric Stimulation; | 1975 |
Duration of action of neostigmine in man.
Topics: Adult; Anesthesia, Intravenous; Female; Humans; Male; Muscle Contraction; Neostigmine; Time Factors; | 1976 |
The effects of cholinergic agents on ovarian contractility in the rabbit.
Topics: Acetylcholine; Animals; Atropine; Bethanechol Compounds; Chorionic Gonadotropin; Female; Humans; In | 1976 |
Cycrimine on rat diaphragm.
Topics: Acetylcholine; Animals; Antiparkinson Agents; Denervation; Diaphragm; Electric Stimulation; Female; | 1976 |
[Excitant effect of sodium suberogorgin on isolated rabbit ileum].
Topics: Acetylcholinesterase; Animals; Brain; Dose-Response Relationship, Drug; Ileum; In Vitro Techniques; | 1992 |
Neuromuscular pharmacology in rat neonates: development of responsiveness to prototypic blocking and reversal drugs.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Cholinesterase Inhibitors; Curare; Dose-Response | 1992 |
Clinical evaluation of doxacurium chloride.
Topics: Adult; Dose-Response Relationship, Drug; Drug Evaluation; Female; Hemodynamics; Humans; Isoquinoline | 1992 |
Antagonism by beta-eudesmol of neostigmine-induced neuromuscular failure in mouse diaphragms.
Topics: Acetylcholine; Action Potentials; Animals; Diaphragm; Drug Interactions; Drugs, Chinese Herbal; Elec | 1992 |
Influence of plasma cholinesterase activity on recovery from mivacurium-induced neuromuscular blockade in phenotypically normal patients.
Topics: Anesthesia Recovery Period; Cholinesterases; Dibucaine; Electric Stimulation; Flushing; Humans; Infu | 1992 |
Neurokinin receptors mediating substance P-induced contraction in adult rabbit airways.
Topics: Animals; Atropine; Bronchi; Glycopeptides; In Vitro Techniques; Isometric Contraction; Kinetics; Mus | 1990 |
Reversed effect of caffeine on non-contractile and contractile Ca2+ mobilization operated by acetylcholine receptor in mouse diaphragm muscle.
Topics: Animals; Caffeine; Calcium; Diaphragm; Formamides; Male; Mice; Muscle Contraction; Muscles; Neostigm | 1991 |
Noncontractile acetylcholine receptor-operated Ca++ mobilization: suppression of activation by open channel blockers and acceleration of desensitization by closed channel blockers in mouse diaphragm muscle.
Topics: Aequorin; Animals; Anti-Ulcer Agents; Bupivacaine; Calcium; Calcium Channel Blockers; Chlorpromazine | 1991 |
Effects of CCK receptor blockade on intestinal motor activity in conscious dogs.
Topics: Animals; Ceruletide; Cholecystokinin; Digestion; Dogs; Eating; Female; Gastrointestinal Motility; Ma | 1991 |
Antroduodenal coordinated contractions as studied by chemical ablation of myenteric neurons in the gastroduodenal junctional zone.
Topics: Animals; Benzalkonium Compounds; Domperidone; Duodenum; Female; Male; Muscle Contraction; Muscle, Sm | 1991 |
Mechanisms of respiratory failure produced by neostigmine and diisopropyl fluorophosphate.
Topics: Animals; Atropine; Cats; Cholinesterase Inhibitors; Female; In Vitro Techniques; Isoflurophate; Male | 1991 |
Organic calcium channel antagonists provoke acetylcholine receptor autodesensitization on train stimulation of motor nerve.
Topics: Animals; Bungarotoxins; Caffeine; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Diaph | 1990 |
Does suxamethonium influence the subsequent dose requirements of alcuronium and its reversibility in children?
Topics: Adolescent; Alcuronium; Analysis of Variance; Anesthesia Recovery Period; Child; Child, Preschool; D | 1990 |
Contrast in neostigmine-induced changes in spontaneous activities and evoked muscle potentials in rat medial gastrocnemius and soleus muscles.
Topics: Animals; Electric Stimulation; Evoked Potentials; Male; Muscle Contraction; Muscles; Neostigmine; Ra | 1990 |
A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine.
Topics: Animals; Benzamides; Benzyl Compounds; Cholinesterase Inhibitors; Dogs; Domperidone; Dopamine Antago | 1990 |
Cholinergic neurons mediate intestinal propulsion in the rat.
Topics: Animals; Atropine; Female; Gastrointestinal Motility; Hexamethonium; Hexamethonium Compounds; In Vit | 1986 |
Non-competitive effects of disopyramide at the neuromuscular junction: evidence for endplate ion channel block.
Topics: Animals; Carbachol; Chickens; Disopyramide; Dose-Response Relationship, Drug; In Vitro Techniques; I | 1987 |
Noradrenergic, purinergic, and cholinergic transmission in the mouse vas deferens: influence of field-stimulation parameters, reserpinization, 6-hydroxydopamine and 4-aminopyridine.
Topics: 4-Aminopyridine; Adenosine Triphosphate; Aminopyridines; Animals; Atropine; Electric Stimulation; Hy | 1989 |
A dose-response evaluation of pipecuronium bromide in elderly patients under balanced anesthesia.
Topics: Aged; Androstane-3,17-diol; Androstanols; Anesthesia; Dose-Response Relationship, Drug; Female; Huma | 1989 |
Train-of-four as an index of neuromuscular block in cats: changes induced by atropine.
Topics: Analysis of Variance; Animals; Atropine; Cats; Electric Stimulation; Female; Ganglionic Stimulants; | 1989 |
Impairment of the antagonism of vecuronium-induced paralysis and intra-operative disopyramide administration.
Topics: Atropine; Disopyramide; Drug Interactions; Humans; Intraoperative Care; Male; Middle Aged; Muscle Co | 1989 |
Electrical and mechanical responses of guinea-pig bladder muscle to nerve stimulation.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Atropine; Calcium; Electric Stimulation; Guinea Pigs | 1989 |
Effects of respiratory and metabolic alkalosis and acidosis on pipecuronium neuromuscular block.
Topics: Acidosis; Acidosis, Respiratory; Alkalosis; Alkalosis, Respiratory; Androstane-3,17-diol; Androstano | 1988 |
Self-cancellation of drug properties as a mode of organ selectivity: the antimuscarinic effects of ambenonium.
Topics: Acetylcholine; Acetylcholinesterase; Ambenonium Chloride; Animals; Bethanechol; Bethanechol Compound | 1985 |
Neuromuscular blocking action of vecuronium in the dog and its reversal by neostigmine.
Topics: Analysis of Variance; Anesthesia, General; Animals; Atropine; Blood Pressure; Dogs; Drug Antagonism; | 1985 |
Edrophonium and neostigmine for reversal of the neuromuscular blocking effect of vecuronium.
Topics: Adult; Edrophonium; Female; Humans; Laparoscopy; Muscle Contraction; Neostigmine; Neuroleptanalgesia | 1985 |
Vecuronium in the myasthenic patient.
Topics: Adolescent; Adult; Aged; Drug Administration Schedule; Drug Evaluation; Female; Humans; Male; Middle | 1985 |
In pursuit of relaxation.
Topics: Anesthesia; Atracurium; Curare; Decamethonium Compounds; History, 20th Century; Humans; Muscle Contr | 1986 |
Reversal by atropine of tetanic fade induced in cats by antinicotinic and anticholinesterase agents.
Topics: Animals; Atropine; Cats; Cholinesterase Inhibitors; Drug Interactions; Electric Stimulation; Female; | 1987 |
Electrical and mechanical responses after neuromuscular blockade with vecuronium, and subsequent antagonism with neostigmine or edrophonium.
Topics: Adult; Aged; Edrophonium; Electromyography; Humans; Middle Aged; Muscle Contraction; Neostigmine; Ne | 1987 |
[Antagonism of an intubation dose of vecuronium].
Topics: Anesthesia; Edrophonium; Halothane; Humans; Intubation; Muscle Contraction; Muscle Relaxation; Neost | 1987 |
Effects of haloperidol on neurotransmitter activity in the rat vas deferens.
Topics: Acetylcholinesterase; Animals; Catecholamines; Haloperidol; In Vitro Techniques; Male; Muscle Contra | 1988 |
The site of action of trimethaphan-induced neuromuscular blockade in isolated rat and frog muscle.
Topics: Animals; Bungarotoxins; Caffeine; Carbachol; Electric Stimulation; Hexamethonium; Hexamethonium Comp | 1988 |
Reversals of the neostigmine-induced tetanic fade and endplate potential run-down with respect to the autoregulation of transmitter release.
Topics: Animals; Choline; Female; Hexamethonium; Hexamethonium Compounds; Homeostasis; In Vitro Techniques; | 1988 |
Effects of distention and neostigmine on jejunal vascular resistance, oxygen uptake, and intraluminal pressure changes in ponies.
Topics: Animals; Horses; Jejunum; Muscle Contraction; Neostigmine; Oxygen Consumption; Pressure; Vascular Re | 1989 |
[Experimental observation on the dynamics of common bile ducts obstructed by calculi].
Topics: Animals; Bile Ducts; Gallstones; Medicine, Chinese Traditional; Medicine, East Asian Traditional; Mu | 1985 |
[Course of the neuromuscular block under atracurium. Comparison with alcuronium].
Topics: Adolescent; Adult; Alcuronium; Anesthesia, General; Atracurium; Female; Humans; Isoquinolines; Male; | 1985 |
Effect of meptazinol on neuromuscular transmission in the isolated rat phrenic nerve-diaphragm preparation.
Topics: Animals; Azepines; Cholinesterase Inhibitors; Drug Synergism; In Vitro Techniques; Male; Meptazinol; | 1985 |
Muscle paralyzing effect of the juice from the trunk of the banana tree.
Topics: Action Potentials; Animals; Chickens; Diaphragm; In Vitro Techniques; Mice; Motor Endplate; Muscle C | 1985 |
Endplate channel actions of a hemicholinium-3 analog, DMAE.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Hemicholinium 3; In Vitro Techniques; Memb | 1986 |
An intrinsic neural pathway for long intestino-intestinal inhibitory reflexes.
Topics: Animals; Dogs; Female; Gastrointestinal Motility; Intestine, Small; Male; Muscle Contraction; Muscle | 1987 |
Recovery of respiration after neuromuscular blockade with alcuronium.
Topics: Adolescent; Adult; Alcuronium; Humans; Male; Middle Aged; Muscle Contraction; Neostigmine; Nerve Blo | 1987 |
The pharmacology of anatoxin-a(s), a neurotoxin produced by the freshwater cyanobacterium Anabaena flos-aquae NRC 525-17.
Topics: Acetylcholine; Animals; Atropine; Bacterial Toxins; Chickens; Cholinesterases; Chromatography, High | 1986 |
A comparison of edrophonium and neostigmine for the antagonism of atracurium-induced neuromuscular block.
Topics: Adult; Atracurium; Edrophonium; Humans; Isoquinolines; Middle Aged; Muscle Contraction; Neostigmine; | 1985 |
Desensitization of the isolated bovine iris sphincter muscles by pilocarpine.
Topics: Acetylcholine; Animals; Carbachol; Cattle; Drug Interactions; Drug Tolerance; In Vitro Techniques; I | 1988 |
Effect of suxamethonium given during recovery from atracurium.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Atracurium; Drug Interactions; Humans; Middle Aged; Mu | 1988 |
Distinctive characteristics of the splenic vein in the dog. Its morphological and pharmacological discontinuities with the portal vein and splenic capsule.
Topics: Animals; Dogs; In Vitro Techniques; Isoproterenol; Muscle Contraction; Muscle, Smooth, Vascular; Neo | 1988 |
Mechanisms of the contractile responses to morphine of the mouse colon in vitro.
Topics: Animals; Colon; In Vitro Techniques; Methadone; Mice; Morphine; Morphine Dependence; Muscle Contract | 1988 |
Possible mechanisms related to contraction of the bovine iris sphincter in the presence of acetylcholine and carbachol.
Topics: Acetylcholine; Animals; Carbachol; Cattle; Dose-Response Relationship, Drug; Indomethacin; Iris; Mus | 1988 |
Neural control of contraction in isolated submucosal gland from feline trachea.
Topics: Adrenergic Fibers; Animals; Atropine; Cats; Cholinergic Fibers; Dimethylphenylpiperazinium Iodide; E | 1987 |
Excitatory cholinergic innervation in canine portal and mesenteric veins.
Topics: Acetylcholine; Animals; Atropine; Cholinesterases; Dogs; Electric Stimulation; Female; Histocytochem | 1988 |
Glycopyrrolate intensifies neuromuscular blockade produced by atracurium in the rat diaphragm preparation.
Topics: Animals; Atracurium; Glycopyrrolate; In Vitro Techniques; Male; Muscle Contraction; Neostigmine; Neu | 1987 |
Giant migrating contractions during defecation in the dog colon.
Topics: Animals; Castor Oil; Catheterization; Colon; Defecation; Dogs; Female; Glucose; Guanethidine; Male; | 1987 |
Neostigmine in the antagonism of the action of atracurium.
Topics: Atracurium; Female; Humans; Male; Middle Aged; Muscle Contraction; Neostigmine; Time Factors | 1987 |
Distribution of cholinesterase in canine venous system.
Topics: Animals; Cholinesterases; Dogs; Female; Histocytochemistry; In Vitro Techniques; Male; Muscle Contra | 1987 |
Lower airway smooth muscle contraction induced by Ptychodiscus brevis (red tide) toxin.
Topics: Acetylcholine; Alprostadil; Animals; Atropine; Dogs; Marine Toxins; Muscle Contraction; Muscle, Smoo | 1987 |
Interaction of adrenaline with neostigmine and tubocurarine at the skeletal neuromuscular junction.
Topics: Animals; Drug Interactions; Epinephrine; In Vitro Techniques; Male; Muscle Contraction; Neostigmine; | 1987 |
Pre- and postsynaptic effects of nicotine on the mouse phrenic nerve-diaphragm preparation.
Topics: 4-Aminopyridine; Amifampridine; Aminopyridines; Animals; Calcium; Diaphragm; Electric Stimulation; F | 1987 |
Interaction of verapamil with atracurium and reversal of combined neuromuscular blockade with edrophonium and neostigmine.
Topics: Animals; Atracurium; Edrophonium; In Vitro Techniques; Muscle Contraction; Neostigmine; Neuromuscula | 1987 |
Effectiveness of physostigmine as a pretreatment drug for protection of rats from organophosphate poisoning.
Topics: Acetylcholinesterase; Action Potentials; Animals; Atropine; Body Weight; Brain; Brain Chemistry; Cho | 1986 |
Mechanisms of the inhibition by neostigmine of tetanic contraction in the mouse diaphragm.
Topics: Action Potentials; Animals; Carbachol; Diaphragm; Electric Stimulation; Female; Isometric Contractio | 1986 |
A study of the contractile response to acetylcholine in human ileal and detrusor muscle: origin of the low efficacy of acetylcholine.
Topics: Acetylcholine; Animals; Carbachol; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Muscle Contracti | 1986 |
Profound atracurium induced neuromuscular blockade. A comparison of evoked reversal with edrophonium or neostigmine.
Topics: Adult; Atracurium; Edrophonium; Humans; Isoquinolines; Muscle Contraction; Neostigmine; Neuromuscula | 1986 |
Phenazine methosulfate induces a neurally-mediated contraction of the guinea-pig ileum.
Topics: Acetylcholine; Animals; Atropine; Female; Guinea Pigs; Ileum; Male; Methylphenazonium Methosulfate; | 1986 |
Evoked electromyographic and mechanical responses of the adductor pollicis compared during the onset of neuromuscular blockade by atracurium or alcuronium, and during antagonism by neostigmine.
Topics: Adult; Alcuronium; Atracurium; Electromyography; Evoked Potentials; Humans; Muscle Contraction; Musc | 1986 |
Antagonism of atracurium-induced neuromuscular blockade by neostigmine or edrophonium.
Topics: Atracurium; Edrophonium; Humans; Muscle Contraction; Neostigmine; Neuromuscular Blocking Agents; Tim | 1986 |
Interaction of verapamil with gallamine and pancuronium and reversal of combined neuromuscular blockade with neostigmine and edrophonium.
Topics: Animals; Chickens; Drug Interactions; Edrophonium; Gallamine Triethiodide; In Vitro Techniques; Musc | 1986 |
Tetraethylammonium-methohexitone induced contractures and miniature end-plate potential discharge in the chick biventer cervicis muscle.
Topics: Animals; Chickens; In Vitro Techniques; Membrane Potentials; Methohexital; Motor Endplate; Muscle Co | 1986 |
Antihistaminic properties of AF-14, an experimental quinuclidine derivative: discrimination between two histaminergic sites in both guinea-pig ileum and bladder.
Topics: Animals; Atropine; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Male; Muscle Contraction; Mus | 1985 |
The relative potencies of some agonists at M2 muscarinic receptors in guinea-pig ileum, atria and bronchi.
Topics: Acetylcholine; Animals; Arecoline; Atrial Function; Bronchi; Carbachol; Choline; Guinea Pigs; Heart | 1985 |
Antagonism of phase II succinylcholine block by neostigmine.
Topics: Adult; Aged; Humans; Infusions, Parenteral; Middle Aged; Muscle Contraction; Neostigmine; Neuromuscu | 1985 |
Histamine-mediated acetylcholine release in the guinea-pig ileum.
Topics: Acetylcholine; Adenosine; Animals; Atropine; Guinea Pigs; Histamine; Ileum; In Vitro Techniques; Mal | 1985 |
Response differences of paretic and healthy extremities to pancuronium and neostigmine in hemiplegic patients.
Topics: Adult; Aged; Electric Stimulation; Female; Hemiplegia; Humans; Male; Middle Aged; Muscle Contraction | 1985 |
Effects of aminophylline, isoproterenol, and neostigmine on hypercapnic depression of diaphragmatic contractility.
Topics: Aminophylline; Animals; Diaphragm; Dogs; Electric Stimulation; Hypercapnia; Isoproterenol; Muscle Co | 1985 |
The neural and non-neural mechanisms involved in urethral activity in rabbits.
Topics: Action Potentials; Animals; Atropine; Guanethidine; In Vitro Techniques; Indomethacin; Male; Membran | 1985 |
[Neurophysiological studies on the temporary paresis in myotonia congenita and dystrophia myotonica].
Topics: Action Potentials; Adult; Cell Membrane; Female; Guanidines; Humans; Magnesium; Male; Middle Aged; M | 1973 |
The mean duration of motor unit action potentials in patients with myasthenia gravis.
Topics: Action Potentials; Adenosine Triphosphatases; Calcium; Humans; Motor Neurons; Muscle Contraction; Mu | 1972 |
Neuromuscular blocking effect of aminoglycoside antibiotics in nonhuman primates.
Topics: Aminoglycosides; Animals; Anti-Bacterial Agents; Calcium Chloride; Dihydrostreptomycin Sulfate; Gent | 1973 |
Neuromuscular blocking and local anaesthetic activities of warifteine hydrochloride, an alkaloid isolated from Cissampelos ovalifolia D.C.
Topics: Acetylcholine; Alkaloids; Anesthetics, Local; Animals; Cats; In Vitro Techniques; Isoquinolines; Mus | 1972 |
The binding of (3H)-propylbenzilycholine mustard by longitudinal muscle strips from guinea-pig small intestine.
Topics: Alkylating Agents; Animals; Atropine; Benzilates; Binding Sites; Choline; Guinea Pigs; In Vitro Tech | 1974 |
In vitro studies of human ovarian contractility.
Topics: Adult; Atropine; Bethanechol Compounds; Depression, Chemical; Female; Humans; Isoproterenol; Menopau | 1974 |
Effects of quaternary ammonium compounds on the movement of potassium out of the cerebrospinal fluid.
Topics: Animals; Biological Transport; Cats; Choline; Decamethonium Compounds; Female; Hexamethonium Compoun | 1968 |
[Pharmacodynamic evaluation of a new synthetic curare-like agent: acetylenic-gallamine].
Topics: Acetylene; Animals; Anura; Blood Pressure; Cats; Chemical Phenomena; Chemistry; Chickens; Diaphragm; | 1970 |
Some effects of the steroidal muscle relaxant, dacuronium bromide, in anaesthetized patients.
Topics: Androstanes; Anesthesia, General; Blood Pressure; Electrophysiology; Halothane; Heart Rate; Humans; | 1971 |
Interactions of serotonin with neuromuscular blocking agents.
Topics: Animals; Blood Pressure; Cats; Cell Membrane Permeability; Chickens; Decamethonium Compounds; Diaphr | 1972 |
Comparative antagonism of d-tubocurarine-, gallamine-, and pancuronium-induced neuromuscular blockades by neostigmine.
Topics: Adult; Aged; Analysis of Variance; Androstanes; Dose-Response Relationship, Drug; Drug Antagonism; G | 1972 |
Post-tetanic fibrillary potentials in rat skeletal muscle. Site of origin.
Topics: Abdominal Muscles; Acetylcholine; Action Potentials; Animals; Calcium; Calcium Chloride; Citrates; E | 1973 |
Clinical evaluation of a new non-depolarising muscle relaxant.
Topics: Acid-Base Equilibrium; Atropine; Azo Compounds; Blood Pressure; Carbon Dioxide; Heart Rate; Humans; | 1974 |
[Effect of hypothermia on the action of procaine amide at the level of the isolated rat diaphragm].
Topics: Animals; Diaphragm; Electric Stimulation; Hypothermia, Induced; In Vitro Techniques; Ion Exchange; M | 1974 |
Influence of new guanidine derivatives on ganglionic and neuromuscular transmission.
Topics: Acetylcholine; Action Potentials; Animals; Anura; Blood Pressure; Cats; Columbidae; Diaphragm; Elect | 1967 |
Effects of curare-like agents on the block of tetanic contractions produced by neostigmine in the rat.
Topics: Animals; Gallamine Triethiodide; Muscle Contraction; Neostigmine; Neuromuscular Junction; Rats; Scia | 1968 |
Post-tetanic and drug-induced repetitive firing in the soleus muscle of the cat.
Topics: Acetylcholine; Action Potentials; Animals; Cats; Cholinesterases; Electric Stimulation; Muscle Contr | 1969 |
The effects of nondepolarizing relaxants and anticholinesterases on the neuromuscular refractory period of anesthetized man.
Topics: Curare; Electromyography; Gallamine Triethiodide; Humans; Muscle Contraction; Neostigmine; Synaptic | 1969 |
Effects of alpha,alpha'-bis-(dimethylammoniumacetaldehyde diethylacetal)-p,p'-diacetylbiphenyl bromide (DMAE) on neuromuscular transmission.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Anura; Biphenyl Compounds; Chemical Phenomena; Chemist | 1969 |
On the mechanism of the neuromuscular blocking action of cobalt ion.
Topics: Animals; Blood Pressure; Calcium Chloride; Cobalt; Dogs; Electric Stimulation; Female; Injections, I | 1969 |
Neuromuscular blocking activity of gentamicin in cats and mice.
Topics: Animals; Blood Pressure; Cats; Curare; Drug Antagonism; Drug Synergism; Female; Gentamicins; Kanamyc | 1969 |
The effect of prostigmin on the basal electromyogram in myasthenia.
Topics: Action Potentials; Adult; Electric Stimulation; Electromyography; Female; Humans; Middle Aged; Muscl | 1970 |
Effects of emetine on neuromuscular transmission.
Topics: Acetylcholine; Animals; Anura; Cats; Diaphragm; Electric Stimulation; Emetine; Female; In Vitro Tech | 1970 |
The effect of prostigmin on the basal electromyogram in myasthenia.
Topics: Action Potentials; Adult; Electric Stimulation; Electromyography; Female; Humans; Middle Aged; Muscl | 1970 |
Interactions of xanthine derivatives, catecholamines and glucose-6-phosphate on the isolated phrenic nerve diaphragm preparation of the rat.
Topics: Aminophylline; Animals; Caffeine; Cyclic AMP; Diaphragm; Hexosephosphates; In Vitro Techniques; Musc | 1971 |
The effect of dopamine and other catecholamines on neuromuscular transmission.
Topics: Animals; Anura; Blood Pressure; Carotid Arteries; Cats; Depression, Chemical; Dihydroxyphenylalanine | 1969 |
The pharmacology of d- and l-carnitine and d- and l-acetylcarnitine. Comparison with choline and acetylcholine.
Topics: Acetates; Acetylcholine; Animals; Anura; Blood Pressure; Brain; Carnitine; Cats; Chickens; Choline; | 1971 |
The facilitatory effects of catechol and phenol at the neuromuscular junction of the cat.
Topics: Acetylcholine; Aminophylline; Animals; Catechols; Cats; Drug Interactions; Drug Synergism; Electric | 1971 |
Studies on the neuropharmacology of papaverine. I. The curare-like action isolated nerve-muscle preparation.
Topics: Acetylcholine; Animals; Caffeine; Depression, Chemical; Diaphragm; Drug Interactions; Drug Synergism | 1971 |
Studies on the neuropharmacology of papaverine. II. The effect on neuromuscular transmission in the whole animal.
Topics: Animals; Blood Pressure; Cats; Decamethonium Compounds; Depression, Chemical; Drug Interactions; Dru | 1971 |
Effect of germine acetates on neuromuscular transmission.
Topics: Acetates; Action Potentials; Animals; Electric Stimulation; Muscle Contraction; Muscles; Myasthenia | 1971 |
Effects of muscarinic ganglionic stimulation and blockade upon ganglion responses to DMPP and nicotine.
Topics: Animals; Atropine; Blood Pressure; Depression, Chemical; Dimethylphenylpiperazinium Iodide; Dogs; Dr | 1970 |
Peripheral neuropathy with myokymia, sustained muscular contraction, and continuous motor unit activity.
Topics: Action Potentials; Adult; Calcium; Decamethonium Compounds; Demyelinating Diseases; Edrophonium; Ele | 1972 |
[Negative inotropic effects of endogenous acetylcholine on ventricular myocardium of cat and chicken].
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Catecholamines; Chick Embryo; Chickens; Drug In | 1972 |
The effect of a hemicholinium analogue, HC-15, of neuromuscular transmission.
Topics: Acetylcholine; Animals; Anura; Brain; Cats; Choline; Cholinesterase Inhibitors; Guinea Pigs; Hemicho | 1971 |
Effects of muscle stretch on transmitter release at end-plates of rat diaphragm and frog sartorius muscle.
Topics: Animals; Anura; Calcium; Diaphragm; Electrophysiology; In Vitro Techniques; Magnesium; Membrane Pote | 1973 |
Effect of propranolol on the isolated phrenic nerve-diaphragm preparation of the rat.
Topics: Action Potentials; Animals; Diaphragm; Drug Synergism; Electric Stimulation; Male; Muscle Contractio | 1973 |
Paralysis periodica paramyotonica. A clinical and neurophysiological study.
Topics: Acetazolamide; Acetylcholine; Adult; Alanine Transaminase; Aspartate Aminotransferases; Calcium; Cre | 1974 |
Adverse interaction between steroid hormones and anticholinesterase drugs.
Topics: Action Potentials; Animals; Anura; Cholinesterase Inhibitors; Dexamethasone; Drug Interactions; Edro | 1974 |
The diagnosis and management of myasthenia gravis.
Topics: Adrenocorticotropic Hormone; Edrophonium; Electric Stimulation; Evoked Potentials; Fingers; Humans; | 1974 |
[Proceedings: Chemical transmission of nerve impluses in the cuttlefish (Sepia officinalis)].
Topics: Acetylcholine; Autonomic Agents; Humans; Mollusca; Movement; Muscle Contraction; Neostigmine; Recept | 1973 |
Twitch responses with acetylcholine in the isolated innervated and chronically denervated rat diaphragms and their modification by neuromuscular blocking agents.
Topics: Acetylcholine; Animals; Decamethonium Compounds; Diaphragm; Electric Stimulation; In Vitro Technique | 1965 |
An analysis of the action of drugs on the circular muscle strips from the caecum of the guinea-pig.
Topics: Acetylcholine; Animals; Cecum; Cocaine; Cold Temperature; Drug Synergism; Ganglia; Guinea Pigs; Hist | 1966 |
Some pharmacological activities of crotonosine and pronuciferine.
Topics: Acetylcholine; Anesthetics; Animals; Anura; Diaphragm; Drug Antagonism; Drug Synergism; Electric Sti | 1967 |
A quantitative comparison of the antagonism of tubocurarine and diallylnortoxiferine by four anticurare agents.
Topics: Ambenonium Chloride; Animals; Cholinesterase Inhibitors; Curare; Diaphragm; Drug Antagonism; Edropho | 1967 |
Effects of acetylcholine on the heart.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Coronary Vessels; Depression, Chemical; Dogs; Etha | 1968 |
Some pharmacological actions of cyclizine, chlorcyclizine and homchlorcyclizine.
Topics: Acetylcholine; Animals; Anura; Central Nervous System; Conditioning, Psychological; Cyclizine; Diaph | 1969 |
[Ureteral dynamics. II. Influence of the autonomic nervous system on ureteral dynamics. Contribution on the physiology of the ureter].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adult; Animals; Atropine; Autonomic Agents; | 1971 |
Mechanism of action of neostigmine at the neuromuscular junction.
Topics: Androstanes; Animals; Cats; Gallamine Triethiodide; Hexamethonium Compounds; Muscle Contraction; Neo | 1971 |
Action of hydroxychloroquine on m. masseter preparation in rats.
Topics: Animals; Dose-Response Relationship, Drug; Hydroxychloroquine; In Vitro Techniques; Male; Muscle Con | 1974 |
The cumulative neuromuscular blocking effect of neomycin.
Topics: Animals; Calcium; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Female; Male; Muscle | 1974 |
Further observations on depolarizing neuromuscular block: the so-called phase II block.
Topics: Animals; Decamethonium Compounds; Diaphragm; Dose-Response Relationship, Drug; Electric Stimulation; | 1974 |
The action of the aminoglycosidic antibiotic gentamicin of the isolated rat diaphragm. Potentiation of the neuromuscular blocking activity of gentamicin during combined application with muscle relaxant agents and magnesium.
Topics: Animals; Calcium; Diaphragm; Drug Synergism; Electric Stimulation; Gentamicins; In Vitro Techniques; | 1974 |
Absence of recurarization upon rewarming.
Topics: Anesthesia, Intravenous; Animals; Atropine; Blood Pressure; Body Temperature; Dogs; Electric Stimula | 1973 |
The effect of voltage on the time course of end-plate currents.
Topics: Action Potentials; Animals; Anura; Biological Transport; Calcium; Cholinesterase Inhibitors; Curare; | 1972 |
Effect of ethanol on neuromuscular contraction.
Topics: Animals; Diaphragm; Ethanol; Fatigue; In Vitro Techniques; Muscle Contraction; Neostigmine; Neural C | 1972 |
The pre-junctional site of action of Enhydrina schistosa venom at the neuromuscular junction.
Topics: Acetylcholine; Animals; Binding Sites; Cats; Denervation; Dose-Response Relationship, Drug; Drug Syn | 1973 |
Comparison of the potencies of edrophonium, neostigmine and eserine with a new anticholinesterase drug RX 67668 on human tissues.
Topics: Cholinesterase Inhibitors; Colon; Cyclohexanes; Edrophonium; Humans; Ileum; In Vitro Techniques; Mus | 1973 |
Further studies on the interaction between acetylcholine antagonists and anticholinesterases on cat soleus muscle.
Topics: Acetylcholine; Animals; Caffeine; Carboxylic Acids; Cats; Cholinesterase Inhibitors; Drug Interactio | 1973 |
[Relaxometric investigations of galanthamine as an antidote to pancuronium. The technique of relaxometry (author's transl)].
Topics: Adult; Aged; Cholinesterase Inhibitors; Electromyography; Female; Galantamine; Humans; Male; Methods | 1973 |
[Studies on contractile waves of canine stomach by means of mechanical tracing with strain gauge (author's transl)].
Topics: Animals; Dogs; Electromyography; Gastrointestinal Motility; Methods; Muscle Contraction; Muscle, Smo | 1973 |
The response of the cat anococcygeus muscle to nerve or drug stimulation and a comparison with the rat anococcygeus.
Topics: Amphetamine; Animals; Cats; Cocaine; Cold Temperature; Dopamine; Dopamine Antagonists; Dose-Response | 1974 |
Comparative times to peak effect and durations of action of neostigmine and pyridostigmine.
Topics: Anesthesia, Inhalation; Animals; Electric Stimulation; Halothane; Humans; Muscle Contraction; Neosti | 1974 |
Acute experiments on neuroeffector function in canine esophageal achalasia.
Topics: Acetylcholine; Animals; Atropine; Blood Pressure; Bradycardia; Deglutition; Dog Diseases; Dogs; Elec | 1974 |
The peripheral action of ether estimated on isolated nerve-muscle preparation. 3. Antagonistic and synergistic actions of ether and neostigmine by Ole Secher.
Topics: Acetylcholine; Drug Synergism; Electric Stimulation; Ethers; Ethyl Ethers; History, 20th Century; Mu | 1968 |
[Effect of prostigmine on uterine contractions during labor].
Topics: Female; Humans; Labor, Obstetric; Muscle Contraction; Neostigmine; Pregnancy; Uterus | 1967 |
Electromyography of the colon in the unanesthetized cat.
Topics: Action Potentials; Animals; Atropine; Cats; Colon; Electrodes; Electromyography; Fasting; Female; In | 1972 |
Autonomic receptor mechanisms in embryonic chick myocardial cell cultures.
Topics: Acetylcholine; Animals; Carbachol; Chick Embryo; Culture Techniques; Heart; Isoproterenol; Muscle Co | 1971 |
Augmentation of atropine resistant spasms in plexus-containing guinea-pig longitudinal muscle by ganglionic action of the acetylcholinesterase inhibitor BW 284C51 (1:5 bis (p-allyl-dimethylammonium phenyl)-pentan-3-one dibromide).
Topics: Acetylcholine; Allyl Compounds; Aniline Compounds; Animals; Atropine; Cholinesterase Inhibitors; Dru | 1971 |
The effect of lidocaine on twitch potentiation and repetitive neural activity produced by soman and neostigmine.
Topics: 1-Propanol; Action Potentials; Animals; Diaphragm; Electrophysiology; Female; Fluorine; In Vitro Tec | 1971 |
Effects of calcium on neuromuscular block by suxamethonium in dogs.
Topics: Animals; Blood Pressure; Calcium; Calcium Chloride; Depression, Chemical; Dogs; Gallamine Triethiodi | 1971 |
[Further studies on the excitation conduction in the small intestine musculature after studies with extracellular derived action potentials].
Topics: Acetylcholine; Action Potentials; Animals; Atropine; Epinephrine; Heart; Hexamethonium Compounds; In | 1966 |
Patterns of dog gastrointestinal contractile activity monitored in vivo with extraluminal force transducers.
Topics: 5-Hydroxytryptophan; Animals; Colon; Digestion; Dogs; Duodenum; Electrophysiology; Fasting; Female; | 1967 |
Study of the nerve endings in the vas deferens and seminal vesicle of the guinea pig.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Dihydroxyphenylalanine; Electric Stimulation; Guanethi | 1969 |
Quinine-like actions of two 2-amino-2-phenol alkyl derivatives.
Topics: Acetylcholine; Animals; Arrhythmias, Cardiac; Blood Pressure; Butyrates; Carotid Arteries; Cats; Che | 1969 |
The effects of some hemicholinium-like substances on the chick biventer cervicis muscle preparation.
Topics: Acetylcholine; Animals; Animals, Newborn; Bretylium Compounds; Carbachol; Chickens; Choline; Choline | 1969 |
[Frequency-dependent potentiation of a single contraction of the indirectly stimulated phrenico-diaphragmatic preparation of the rat (Beritoff's phenomenon)].
Topics: Acetylcholine; Animals; Depression, Chemical; Diaphragm; Drug Synergism; Electric Stimulation; Muscl | 1969 |
[Dependence of the effects of neostigmine, nivaline and paraoxon on the stimulation frequency].
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Diaphragm; Electric Stimulation; Galantamine; Mot | 1969 |
Electrophysiological studies of the antrum muscle fibers of the guinea pig stomach.
Topics: Acetylcholine; Animals; Atropine; Epinephrine; Guinea Pigs; Manganese; Membrane Potentials; Muscle C | 1970 |
Reactivity of the digestive tract to prostigmine in experimental animals.
Topics: Animals; Colon; Digestive System; Duodenum; Gastrointestinal Motility; Guinea Pigs; Ileum; Muscle Co | 1970 |
New techniques of measurement of relaxants and their antagonists.
Topics: Colon; Decamethonium Compounds; Gallamine Triethiodide; Gastrointestinal Motility; Halothane; Humans | 1970 |
Responses of skeletal muscle to dehydroemetine.
Topics: Acetylcholine; Animals; Anura; Cats; Diaphragm; Emetine; Muscle Contraction; Neostigmine; Phrenic Ne | 1970 |
[The significance of H-cholinoreceptor sulfhydryl groups in the mechanism of proserine action].
Topics: Animals; Female; Ileum; Muscle Contraction; Muscle, Smooth; Neostigmine; Rats; Sensory Receptor Cell | 1970 |
Stimulus frequency in the detection of neuromuscular block in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Consciousness; Electric Stimulation; Humans; Middle Ag | 1970 |
Stimulus frequency in the detection of neuromuscular block in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Consciousness; Electric Stimulation; Humans; Middle Ag | 1970 |
Stimulus frequency in the detection of neuromuscular block in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Consciousness; Electric Stimulation; Humans; Middle Ag | 1970 |
Stimulus frequency in the detection of neuromuscular block in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Consciousness; Electric Stimulation; Humans; Middle Ag | 1970 |
Stimulus frequency in the detection of neuromuscular block in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Consciousness; Electric Stimulation; Humans; Middle Ag | 1970 |
Stimulus frequency in the detection of neuromuscular block in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Consciousness; Electric Stimulation; Humans; Middle Ag | 1970 |
Stimulus frequency in the detection of neuromuscular block in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Consciousness; Electric Stimulation; Humans; Middle Ag | 1970 |
Stimulus frequency in the detection of neuromuscular block in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Consciousness; Electric Stimulation; Humans; Middle Ag | 1970 |
Stimulus frequency in the detection of neuromuscular block in humans.
Topics: Adolescent; Adult; Aged; Anesthesia, General; Consciousness; Electric Stimulation; Humans; Middle Ag | 1970 |
[Reactivity of isolated rat intestine to choline potentiating compounds].
Topics: Acetylcholine; Ambenonium Chloride; Animals; Cholinesterase Inhibitors; Depression, Chemical; Galant | 1971 |
Observations on an isolated preparation of guinea-pig urinary bladder stimulated through the hypogastric nerves.
Topics: Acetylcholine; Animals; Antihypertensive Agents; Atropine; Autonomic Agents; Bretylium Compounds; Ca | 1967 |
Responses of the guinea-pig vas deferens and urinary bladder to hypogastric nerve stimulation in vivo.
Topics: Animals; Antihypertensive Agents; Atropine; Bretylium Compounds; Electric Stimulation; Ergotamine; G | 1967 |
Effects of an anticholinesterase on the transmitter overflow and the response of the spleen to nerve stimulation.
Topics: Animals; Blood Flow Velocity; Blood Pressure; Cats; Electric Stimulation; In Vitro Techniques; Muscl | 1968 |
The neuromuscular blocking action of some NNN-tris and NN-bis-onium esters.
Topics: Acetylcholine; Animals; Cats; Chickens; Choline; Cholinesterases; Diaphragm; Drug Antagonism; Drug S | 1968 |
The effect of noradrenaline on the end-plate potential in twitch fibres of the frog.
Topics: Acetylcholine; Animals; Anura; Body Fluids; Electrophysiology; Ion Exchange; Iontophoresis; Magnesiu | 1968 |
Pharmacological interaction between pancuronium bromide and anaesthetics.
Topics: 17-Hydroxycorticosteroids; Androstanes; Anesthesia, Conduction; Animals; Blood Pressure; Bromides; C | 1968 |
The inhibitory effect of chlormzanone on tetany and denervated muscle fibrillation in the dog.
Topics: Acetylcholine; Animals; Calcium; Chlormezanone; Dogs; Glycols; Injections, Intravenous; Muscle Contr | 1968 |
U-23,223 (3-chloro-2,5,6-trimiethylbenzoic acid), a veratricic agent selective for the skeletal muscles.
Topics: Animals; Benzoates; Bromides; Electroencephalography; Male; Muscle Contraction; Muscles; Neostigmine | 1968 |
[On receptor mechanism of strychnine at the motor endplate].
Topics: Acetylcholine; Animals; Diaphragm; Muscle Contraction; Muscle Denervation; Neostigmine; Neuromuscula | 1968 |
[Controlled hypotension and muscular activity].
Topics: Benperidol; Drug Synergism; Fentanyl; Humans; Hypotension, Controlled; Muscle Contraction; Neostigmi | 1968 |
[Comparison of the M- and N-choline potentiating activity of proserine and eserine].
Topics: Acetylcholine; Animals; Anura; Drug Synergism; Gastrointestinal Motility; Muscle Contraction; Muscle | 1968 |
[The effect of substances specifically depressing acetylcholine synthesis on the action of pharmacologically choline positive agents].
Topics: Acetylcholine; Amino Alcohols; Animals; Anura; Autonomic Agents; Choline; Hemicholinium 3; Morpholin | 1968 |
Tachyphylaxis to decamethonium and reversibility of the block by anticholinesterase drugs.
Topics: Adult; Anesthesia, Endotracheal; Cholinesterase Inhibitors; Decamethonium Compounds; Electric Stimul | 1969 |
Impairment of motor function of neonatal chicks by hemicholinium treatment during incubation.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Biphenyl Compounds; Chick Embryo; Chickens; Cholineste | 1969 |
The cholinergic effects and rates of hydrolysis of conformationally rigid analogs of acetylcholine.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Anura; Blood Pressure; Chemical Phenomena; Chemistry; | 1969 |
Pharmacological responses of the dorsal longitudinal muscle of Sabellastarte magnifica.
Topics: Acetylcholine; Animals; Annelida; Cholinesterase Inhibitors; Drug Synergism; Epinephrine; Muscle Con | 1969 |
Non-ganglionic effects of nicotine in the pig iris sphincter.
Topics: Acetylcholine; Animals; Atropine; Denervation; Hexamethonium Compounds; Iris; Isoflurophate; Muscle | 1965 |
Transmitter release in the rat diaphragm during tetanic nerve stimulation.
Topics: Animals; Diaphragm; Electrophysiology; Muscle Contraction; Neostigmine; Rats | 1965 |
Blockade of the facilitative action of neostigmine on muscular contraction by the antibiotic colistin.
Topics: Animals; Colistin; Guinea Pigs; Male; Muscle Contraction; Neostigmine | 1965 |
A comparison of the effects of neuromuscular blocking agents and cholinesterase inhibitors on the tibialis anterior and superior rectus muscles of the cat.
Topics: Animals; Cats; Cholinesterase Inhibitors; Curare; In Vitro Techniques; Muscle Contraction; Muscles; | 1966 |
The effect of 2,4-dinitrophenol on neuromuscular transmission.
Topics: Acetylcholine; Adenosine Triphosphate; Animals; Choline; Diaphragm; Dinitrophenols; Electric Stimula | 1966 |
The longitudinal muscle component of the peristaltic reflex in the guinea-pig isolated ileum.
Topics: Acetylcholine; Animals; Atropine; Cholinesterase Inhibitors; Cocaine; Gastrointestinal Motility; Gui | 1966 |
Electrophysiological study of neuromuscular blocking action of cobra neurotoxin.
Topics: Action Potentials; Animals; Anura; Diaphragm; Drug Antagonism; Drug Synergism; Electric Stimulation; | 1966 |
[Studies on the myotropic effect of 5-hydroxytryptamine].
Topics: Animals; Electromyography; Muscle Contraction; Neostigmine; Rabbits; Serotonin | 1966 |