Page last updated: 2024-10-31

neostigmine and Morbid Obesity

neostigmine has been researched along with Morbid Obesity in 8 studies

Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.

Research Excerpts

ExcerptRelevanceReference
"Prospective observational series of consecutive patients scheduled for laparoscopic bariatric surgery in whom neuromuscular blockade was reverted with sugammadex were compared with a historical matched cohort of patients reverted with neostigmines."7.80Postoperative respiratory outcomes in laparoscopic bariatric surgery: comparison of a prospective group of patients whose neuromuscular blockade was reverted with sugammadex and a historical one reverted with neostigmine. ( Cabrera, A; Camprubí, I; Ferreres, E; Llauradó, S; Sabaté, A, 2014)
" We evaluated the role of sugammadex versus neostigmine in the quality of recovery from profound rocuronium-induced neuromuscular blockade (NMB) in patients with morbid obesity."5.17Sugammadex allows fast-track bariatric surgery. ( Carron, M; Foletto, M; Ori, C; Veronese, S, 2013)
" In the patient described in this article, heart block occurred and the Q-Tc interval became prolonged after muscle relaxant reversal with neostigmine; both were considered to be related to the combination of agents used in the case, as well as to other predisposing factors such as morbid obesity."4.84Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report. ( Shields, JA, 2008)
"Prospective observational series of consecutive patients scheduled for laparoscopic bariatric surgery in whom neuromuscular blockade was reverted with sugammadex were compared with a historical matched cohort of patients reverted with neostigmines."3.80Postoperative respiratory outcomes in laparoscopic bariatric surgery: comparison of a prospective group of patients whose neuromuscular blockade was reverted with sugammadex and a historical one reverted with neostigmine. ( Cabrera, A; Camprubí, I; Ferreres, E; Llauradó, S; Sabaté, A, 2014)
"However, the effect of this agent in postoperative pain is still unknown."2.79Sugammadex reduces postoperative pain after laparoscopic bariatric surgery: a randomized trial. ( Borges, S; Castro, DS; Figueiredo, P; Gomes, L; Leão, P; Pacheco, M, 2014)
" Consequently, incorrect dosing will increase the rate of perioperative complications."2.46Perioperative pharmacology in morbid obesity. ( Lemmens, HJ, 2010)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's6 (75.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Carron, M2
Veronese, S1
Foletto, M1
Ori, C2
Llauradó, S1
Sabaté, A1
Ferreres, E1
Camprubí, I1
Cabrera, A1
Castro, DS1
Leão, P1
Borges, S1
Gomes, L1
Pacheco, M1
Figueiredo, P1
Lemmens, HJ1
Gaszynski, T1
Szewczyk, T1
Gaszynski, W1
Parotto, E1
Schumann, R1
Tarnoff, M1
Siddiqui, ZI1
Shields, JA1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparing Deep Neuromuscular Block and Moderate Neuromuscular Block in Patients Undergoing Laparoscopic Gynaecological Surgeries: Impact on Surgical Satisfaction of Operating Conditions and Patient Satisfaction[NCT02794714]Phase 40 participants (Actual)Interventional2016-06-30Withdrawn (stopped due to unresolved budget issues)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

2 reviews available for neostigmine and Morbid Obesity

ArticleYear
Perioperative pharmacology in morbid obesity.
    Current opinion in anaesthesiology, 2010, Volume: 23, Issue:4

    Topics: Analgesics, Opioid; Anesthetics; Anesthetics, Inhalation; Animals; Body Mass Index; Body Weight; Cho

2010
Heart block and prolonged Q-Tc interval following muscle relaxant reversal: a case report.
    AANA journal, 2008, Volume: 76, Issue:1

    Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalati

2008

Trials

3 trials available for neostigmine and Morbid Obesity

ArticleYear
Sugammadex allows fast-track bariatric surgery.
    Obesity surgery, 2013, Volume: 23, Issue:10

    Topics: Adult; Anesthesia Recovery Period; Bariatric Surgery; Female; gamma-Cyclodextrins; Humans; Male; Mid

2013
Sugammadex reduces postoperative pain after laparoscopic bariatric surgery: a randomized trial.
    Surgical laparoscopy, endoscopy & percutaneous techniques, 2014, Volume: 24, Issue:5

    Topics: Adult; Bariatric Surgery; Female; gamma-Cyclodextrins; Humans; Laparoscopy; Male; Neostigmine; Obesi

2014
Randomized comparison of sugammadex and neostigmine for reversal of rocuronium-induced muscle relaxation in morbidly obese undergoing general anaesthesia.
    British journal of anaesthesia, 2012, Volume: 108, Issue:2

    Topics: Adult; Androstanols; Anesthesia Recovery Period; Anthropometry; Bariatric Surgery; gamma-Cyclodextri

2012

Other Studies

3 other studies available for neostigmine and Morbid Obesity

ArticleYear
Postoperative respiratory outcomes in laparoscopic bariatric surgery: comparison of a prospective group of patients whose neuromuscular blockade was reverted with sugammadex and a historical one reverted with neostigmine.
    Revista espanola de anestesiologia y reanimacion, 2014, Volume: 61, Issue:10

    Topics: Adult; Aged; Bariatric Surgery; Cholinesterase Inhibitors; Female; gamma-Cyclodextrins; Humans; Lapa

2014
Prolonged neuromuscular block associated to non-alcoholic steatohepatitis in morbidly obese patient: neostigmine versus sugammadex.
    Minerva anestesiologica, 2012, Volume: 78, Issue:1

    Topics: Adult; Biopsy; Cholinesterase Inhibitors; Fatty Liver; gamma-Cyclodextrins; Humans; Male; Monitoring

2012
Minimally invasive gastric bypass in a morbidly obese patient with myasthenia gravis.
    Obesity surgery, 2004, Volume: 14, Issue:9

    Topics: Anesthesia, Inhalation; Anesthetics, Local; Cholinesterase Inhibitors; Comorbidity; Female; Gastric

2004