Page last updated: 2024-10-31

neostigmine and Ileus

neostigmine has been researched along with Ileus in 11 studies

Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.

Ileus: A condition caused by the lack of intestinal PERISTALSIS or INTESTINAL MOTILITY without any mechanical obstruction. This interference of the flow of INTESTINAL CONTENTS often leads to INTESTINAL OBSTRUCTION. Ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced.

Research Excerpts

ExcerptRelevanceReference
"Thoracic epidural neostigmine enables faster restoration of bowel sounds and shortens duration of postoperative ileus after abdominal aortic surgery."9.13A prospective randomized double-blind study to determine the effect of thoracic epidural neostigmine on postoperative ileus after abdominal aortic surgery. ( Bozdogan, N; Caliskan, E; Gulcan, O; Sener, M; Turkoz, A; Turkoz, R, 2008)
"The aim of this study was to assess the effects of neostigmine on the postoperative ileus and the healing of colon anastomoses."7.77The effect of neostigmine on postoperative ileus and the healing of colon anastomoses. ( Durgun, V; Ekci, B; Emirleroglu, M, 2011)
"We demonstrate facilitated gut decontamination temporally associated with administration of neostigmine in two patients judged to have drug-induced ileus following overdose."7.73Use of neostigmine for the management of drug induced ileus in severe poisonings. ( Chan, B; Dawson, A; Downes, M; Whyte, I, 2005)
"Neostigmine was used safely in our patients and may be safe and efficacious for the treatment of refractory ileus in pediatric patients after liver transplantation."5.51Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation. ( Balakrishnan, B; Hong, JC; Petersen, PC; Vitola, B, 2019)
"Thoracic epidural neostigmine enables faster restoration of bowel sounds and shortens duration of postoperative ileus after abdominal aortic surgery."5.13A prospective randomized double-blind study to determine the effect of thoracic epidural neostigmine on postoperative ileus after abdominal aortic surgery. ( Bozdogan, N; Caliskan, E; Gulcan, O; Sener, M; Turkoz, A; Turkoz, R, 2008)
"The aim of this study was to investigate the efficacy of gastrografin, neostigmine, and their combined administration in patients diagnosed with paralytic ileus in the postoperative period."4.31The efficacy and results of medical treatment in postoperative ileus. ( Alkan, S; Cakir, M; Duyan, AG; Sentiurk, M; Varman, A, 2023)
"The aim of this study was to assess the effects of neostigmine on the postoperative ileus and the healing of colon anastomoses."3.77The effect of neostigmine on postoperative ileus and the healing of colon anastomoses. ( Durgun, V; Ekci, B; Emirleroglu, M, 2011)
"We demonstrate facilitated gut decontamination temporally associated with administration of neostigmine in two patients judged to have drug-induced ileus following overdose."3.73Use of neostigmine for the management of drug induced ileus in severe poisonings. ( Chan, B; Dawson, A; Downes, M; Whyte, I, 2005)
"Neostigmine was used safely in our patients and may be safe and efficacious for the treatment of refractory ileus in pediatric patients after liver transplantation."1.51Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation. ( Balakrishnan, B; Hong, JC; Petersen, PC; Vitola, B, 2019)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (45.45)29.6817
2010's2 (18.18)24.3611
2020's4 (36.36)2.80

Authors

AuthorsStudies
Traeger, L1
Hall, TD1
Bedrikovetski, S2
Kroon, HM2
Dudi-Venkata, NN2
Moore, JW2
Sammour, T2
Alkan, S1
Cakir, M1
Sentiurk, M1
Varman, A1
Duyan, AG1
Petersen, PC1
Balakrishnan, B1
Vitola, B1
Hong, JC1
Hunt, ME1
Yates, JR1
Vega, H1
Heidel, RE1
Buehler, JM1
Zeinali, F1
Stulberg, JJ1
Delaney, CP1
Emirleroglu, M1
Ekci, B1
Durgun, V1
Behm, B1
Stollman, N1
Baggot, MG1
Chan, B1
Whyte, I1
Dawson, A1
Downes, M1
Caliskan, E1
Turkoz, A1
Sener, M1
Bozdogan, N1
Gulcan, O1
Turkoz, R1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
A Prospective Randomized Control Trial of The Effectiveness of Entereg as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery[NCT02742181]Phase 314 participants (Actual)Interventional2015-12-02Terminated (stopped due to terminated due to lack of enrollment)
A Randomized Trial of Alvimopan for the Reduction of Ileus After Long Posterior Spinal Fusion[NCT02218190]31 participants (Actual)Interventional2014-08-31Completed
A Prospective Randomized Control Trial of The Effectiveness of Alvimopan as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery[NCT04405037]Phase 458 participants (Anticipated)Interventional2020-08-01Recruiting
Measurement Of GI Myoelectric Activity In Patients At Risk For Or Who Have A Post-Operative Ileus (POI) - Monitoring/ Recording GI Myoelectric Activity For Early Detection of A POI[NCT02673671]150 participants (Anticipated)Observational2016-02-29Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Complications

All adverse events (NCT02742181)
Timeframe: 30 days

InterventionNumber of AEs (Number)
Alvimopan Group4
Control Group6

Hospital Length of Stay

Date of surgery until discharge (NCT02742181)
Timeframe: up to 30 days

InterventionDays (Median)
Alvimopan Group9
Control Group8.5

Number of Readmissions

Any readmissions within 30 days of surgery (NCT02742181)
Timeframe: 30 days

InterventionNumber of readmissions (Number)
Alvimopan Group0
Control Group0

Number of Reoperations

Any reoperations within 30 days of surgery (NCT02742181)
Timeframe: 30 days

InterventionNumber of reoperations (Number)
Alvimopan Group0
Control Group0

Complications and Adverse Event

Number of patients with complication/adverse event. (NCT02218190)
Timeframe: 14 days or until hospital discharge, which ever occurs first

InterventionParticipants (Count of Participants)
Alvimopan0
Placebo - Sugar Pill0

Length of Hospital Stay

To determine the effect of alvimopan on overall length of hospital stay in patients undergoing PSF. (NCT02218190)
Timeframe: 14 days or until hospital discharge whichever occurs first

InterventionHours (Mean)
Alvimopan122.5
Placebo - Sugar Pill117.2

Recovery of Bowel Function

To determine the effect of alvimopan on the recovery of bowel function as determined by time to first bowel movement in patients undergoing posterior spinal fusion. The effect size calculated may guide a larger, multicenter randomized controlled study. Time was measured from wound closure to bowel movement. (NCT02218190)
Timeframe: 14 days or until hospital discharge whichever occurs first

InterventionHours (Mean)
Alvimopan43.2
Placebo - Sugar Pill34.0

Reviews

3 reviews available for neostigmine and Ileus

ArticleYear
Systematic scoping review of enhanced recovery protocol recommendations targeting return of gastrointestinal function after colorectal surgery.
    ANZ journal of surgery, 2020, Volume: 90, Issue:1-2

    Topics: Bisacodyl; Chewing Gum; Colonic Diseases; Humans; Ileus; Lactulose; Neostigmine; Piperidines; Postop

2020
Pharmacological management of postoperative ileus.
    Canadian journal of surgery. Journal canadien de chirurgie, 2009, Volume: 52, Issue:2

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal;

2009
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003
Postoperative ileus: etiologies and interventions.
    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2003, Volume: 1, Issue:2

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal

2003

Trials

1 trial available for neostigmine and Ileus

ArticleYear
A prospective randomized double-blind study to determine the effect of thoracic epidural neostigmine on postoperative ileus after abdominal aortic surgery.
    Anesthesia and analgesia, 2008, Volume: 106, Issue:3

    Topics: Adult; Aged; Anesthesia, Epidural; Anesthetics, Local; Aorta, Abdominal; Bupivacaine; Cholinesterase

2008

Other Studies

7 other studies available for neostigmine and Ileus

ArticleYear
Effect of neuromuscular reversal with neostigmine/glycopyrrolate versus sugammadex on postoperative ileus following colorectal surgery.
    Techniques in coloproctology, 2023, Volume: 27, Issue:3

    Topics: Acetylcholinesterase; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Glycopyrrolate; Hu

2023
The efficacy and results of medical treatment in postoperative ileus.
    Nigerian journal of clinical practice, 2023, Volume: 26, Issue:4

    Topics: Diatrizoate Meglumine; Humans; Ileus; Intestinal Pseudo-Obstruction; Neostigmine; Postoperative Comp

2023
Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation.
    Pediatric transplantation, 2019, Volume: 23, Issue:7

    Topics: Child; Child, Preschool; Cholinesterase Inhibitors; Humans; Ileus; Infant; Liver Transplantation; Ma

2019
Effects on Postoperative Gastrointestinal Motility After Neuromuscular Blockade Reversal With Sugammadex Versus Neostigmine/Glycopyrrolate in Colorectal Surgery Patients.
    The Annals of pharmacotherapy, 2020, Volume: 54, Issue:12

    Topics: Cholinesterase Inhibitors; Cohort Studies; Colorectal Surgery; Drug Therapy, Combination; Female; Ga

2020
The effect of neostigmine on postoperative ileus and the healing of colon anastomoses.
    Bratislavske lekarske listy, 2011, Volume: 112, Issue:6

    Topics: Anastomosis, Surgical; Animals; Body Weight; Cholinesterase Inhibitors; Colon; Dietary Proteins; Fem

2011
Endo-abdominal hypertension complicating pregnancy & fetal development.
    Medical hypotheses, 2006, Volume: 67, Issue:5

    Topics: Abdomen; Female; Fetal Development; Humans; Hypertension; Ileus; Male; Neostigmine; Obesity; Parasym

2006
Use of neostigmine for the management of drug induced ileus in severe poisonings.
    Journal of medical toxicology : official journal of the American College of Medical Toxicology, 2005, Volume: 1, Issue:1

    Topics: Adult; Antidotes; Decontamination; Drug Overdose; Female; Gastrointestinal Transit; Humans; Ileus; I

2005