neostigmine and Ileus
neostigmine has been researched along with Ileus in 11 studies
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Ileus: A condition caused by the lack of intestinal PERISTALSIS or INTESTINAL MOTILITY without any mechanical obstruction. This interference of the flow of INTESTINAL CONTENTS often leads to INTESTINAL OBSTRUCTION. Ileus may be classified into postoperative, inflammatory, metabolic, neurogenic, and drug-induced.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thoracic epidural neostigmine enables faster restoration of bowel sounds and shortens duration of postoperative ileus after abdominal aortic surgery." | 9.13 | A prospective randomized double-blind study to determine the effect of thoracic epidural neostigmine on postoperative ileus after abdominal aortic surgery. ( Bozdogan, N; Caliskan, E; Gulcan, O; Sener, M; Turkoz, A; Turkoz, R, 2008) |
| "The aim of this study was to assess the effects of neostigmine on the postoperative ileus and the healing of colon anastomoses." | 7.77 | The effect of neostigmine on postoperative ileus and the healing of colon anastomoses. ( Durgun, V; Ekci, B; Emirleroglu, M, 2011) |
| "We demonstrate facilitated gut decontamination temporally associated with administration of neostigmine in two patients judged to have drug-induced ileus following overdose." | 7.73 | Use of neostigmine for the management of drug induced ileus in severe poisonings. ( Chan, B; Dawson, A; Downes, M; Whyte, I, 2005) |
| "Neostigmine was used safely in our patients and may be safe and efficacious for the treatment of refractory ileus in pediatric patients after liver transplantation." | 5.51 | Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation. ( Balakrishnan, B; Hong, JC; Petersen, PC; Vitola, B, 2019) |
| "Thoracic epidural neostigmine enables faster restoration of bowel sounds and shortens duration of postoperative ileus after abdominal aortic surgery." | 5.13 | A prospective randomized double-blind study to determine the effect of thoracic epidural neostigmine on postoperative ileus after abdominal aortic surgery. ( Bozdogan, N; Caliskan, E; Gulcan, O; Sener, M; Turkoz, A; Turkoz, R, 2008) |
| "The aim of this study was to investigate the efficacy of gastrografin, neostigmine, and their combined administration in patients diagnosed with paralytic ileus in the postoperative period." | 4.31 | The efficacy and results of medical treatment in postoperative ileus. ( Alkan, S; Cakir, M; Duyan, AG; Sentiurk, M; Varman, A, 2023) |
| "The aim of this study was to assess the effects of neostigmine on the postoperative ileus and the healing of colon anastomoses." | 3.77 | The effect of neostigmine on postoperative ileus and the healing of colon anastomoses. ( Durgun, V; Ekci, B; Emirleroglu, M, 2011) |
| "We demonstrate facilitated gut decontamination temporally associated with administration of neostigmine in two patients judged to have drug-induced ileus following overdose." | 3.73 | Use of neostigmine for the management of drug induced ileus in severe poisonings. ( Chan, B; Dawson, A; Downes, M; Whyte, I, 2005) |
| "Neostigmine was used safely in our patients and may be safe and efficacious for the treatment of refractory ileus in pediatric patients after liver transplantation." | 1.51 | Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation. ( Balakrishnan, B; Hong, JC; Petersen, PC; Vitola, B, 2019) |
Research
Studies (11)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (45.45) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 4 (36.36) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Traeger, L | 1 |
| Hall, TD | 1 |
| Bedrikovetski, S | 2 |
| Kroon, HM | 2 |
| Dudi-Venkata, NN | 2 |
| Moore, JW | 2 |
| Sammour, T | 2 |
| Alkan, S | 1 |
| Cakir, M | 1 |
| Sentiurk, M | 1 |
| Varman, A | 1 |
| Duyan, AG | 1 |
| Petersen, PC | 1 |
| Balakrishnan, B | 1 |
| Vitola, B | 1 |
| Hong, JC | 1 |
| Hunt, ME | 1 |
| Yates, JR | 1 |
| Vega, H | 1 |
| Heidel, RE | 1 |
| Buehler, JM | 1 |
| Zeinali, F | 1 |
| Stulberg, JJ | 1 |
| Delaney, CP | 1 |
| Emirleroglu, M | 1 |
| Ekci, B | 1 |
| Durgun, V | 1 |
| Behm, B | 1 |
| Stollman, N | 1 |
| Baggot, MG | 1 |
| Chan, B | 1 |
| Whyte, I | 1 |
| Dawson, A | 1 |
| Downes, M | 1 |
| Caliskan, E | 1 |
| Turkoz, A | 1 |
| Sener, M | 1 |
| Bozdogan, N | 1 |
| Gulcan, O | 1 |
| Turkoz, R | 1 |
Clinical Trials (4)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective Randomized Control Trial of The Effectiveness of Entereg as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery[NCT02742181] | Phase 3 | 14 participants (Actual) | Interventional | 2015-12-02 | Terminated (stopped due to terminated due to lack of enrollment) | ||
| A Randomized Trial of Alvimopan for the Reduction of Ileus After Long Posterior Spinal Fusion[NCT02218190] | 31 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
| A Prospective Randomized Control Trial of The Effectiveness of Alvimopan as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery[NCT04405037] | Phase 4 | 58 participants (Anticipated) | Interventional | 2020-08-01 | Recruiting | ||
| Measurement Of GI Myoelectric Activity In Patients At Risk For Or Who Have A Post-Operative Ileus (POI) - Monitoring/ Recording GI Myoelectric Activity For Early Detection of A POI[NCT02673671] | 150 participants (Anticipated) | Observational | 2016-02-29 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trial Outcomes
Complications
All adverse events (NCT02742181)
Timeframe: 30 days
| Intervention | Number of AEs (Number) |
|---|---|
| Alvimopan Group | 4 |
| Control Group | 6 |
Hospital Length of Stay
Date of surgery until discharge (NCT02742181)
Timeframe: up to 30 days
| Intervention | Days (Median) |
|---|---|
| Alvimopan Group | 9 |
| Control Group | 8.5 |
Number of Readmissions
Any readmissions within 30 days of surgery (NCT02742181)
Timeframe: 30 days
| Intervention | Number of readmissions (Number) |
|---|---|
| Alvimopan Group | 0 |
| Control Group | 0 |
Number of Reoperations
Any reoperations within 30 days of surgery (NCT02742181)
Timeframe: 30 days
| Intervention | Number of reoperations (Number) |
|---|---|
| Alvimopan Group | 0 |
| Control Group | 0 |
Complications and Adverse Event
Number of patients with complication/adverse event. (NCT02218190)
Timeframe: 14 days or until hospital discharge, which ever occurs first
| Intervention | Participants (Count of Participants) |
|---|---|
| Alvimopan | 0 |
| Placebo - Sugar Pill | 0 |
Length of Hospital Stay
To determine the effect of alvimopan on overall length of hospital stay in patients undergoing PSF. (NCT02218190)
Timeframe: 14 days or until hospital discharge whichever occurs first
| Intervention | Hours (Mean) |
|---|---|
| Alvimopan | 122.5 |
| Placebo - Sugar Pill | 117.2 |
Recovery of Bowel Function
To determine the effect of alvimopan on the recovery of bowel function as determined by time to first bowel movement in patients undergoing posterior spinal fusion. The effect size calculated may guide a larger, multicenter randomized controlled study. Time was measured from wound closure to bowel movement. (NCT02218190)
Timeframe: 14 days or until hospital discharge whichever occurs first
| Intervention | Hours (Mean) |
|---|---|
| Alvimopan | 43.2 |
| Placebo - Sugar Pill | 34.0 |
Reviews
3 reviews available for neostigmine and Ileus
| Article | Year |
|---|---|
Systematic scoping review of enhanced recovery protocol recommendations targeting return of gastrointestinal function after colorectal surgery.
Topics: Bisacodyl; Chewing Gum; Colonic Diseases; Humans; Ileus; Lactulose; Neostigmine; Piperidines; Postop | 2020 |
Pharmacological management of postoperative ileus.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Trials
1 trial available for neostigmine and Ileus
| Article | Year |
|---|---|
A prospective randomized double-blind study to determine the effect of thoracic epidural neostigmine on postoperative ileus after abdominal aortic surgery.
Topics: Adult; Aged; Anesthesia, Epidural; Anesthetics, Local; Aorta, Abdominal; Bupivacaine; Cholinesterase | 2008 |
Other Studies
7 other studies available for neostigmine and Ileus
| Article | Year |
|---|---|
Effect of neuromuscular reversal with neostigmine/glycopyrrolate versus sugammadex on postoperative ileus following colorectal surgery.
Topics: Acetylcholinesterase; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Glycopyrrolate; Hu | 2023 |
The efficacy and results of medical treatment in postoperative ileus.
Topics: Diatrizoate Meglumine; Humans; Ileus; Intestinal Pseudo-Obstruction; Neostigmine; Postoperative Comp | 2023 |
Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation.
Topics: Child; Child, Preschool; Cholinesterase Inhibitors; Humans; Ileus; Infant; Liver Transplantation; Ma | 2019 |
Effects on Postoperative Gastrointestinal Motility After Neuromuscular Blockade Reversal With Sugammadex Versus Neostigmine/Glycopyrrolate in Colorectal Surgery Patients.
Topics: Cholinesterase Inhibitors; Cohort Studies; Colorectal Surgery; Drug Therapy, Combination; Female; Ga | 2020 |
The effect of neostigmine on postoperative ileus and the healing of colon anastomoses.
Topics: Anastomosis, Surgical; Animals; Body Weight; Cholinesterase Inhibitors; Colon; Dietary Proteins; Fem | 2011 |
Endo-abdominal hypertension complicating pregnancy & fetal development.
Topics: Abdomen; Female; Fetal Development; Humans; Hypertension; Ileus; Male; Neostigmine; Obesity; Parasym | 2006 |
Use of neostigmine for the management of drug induced ileus in severe poisonings.
Topics: Adult; Antidotes; Decontamination; Drug Overdose; Female; Gastrointestinal Transit; Humans; Ileus; I | 2005 |