Page last updated: 2024-10-31

neostigmine and Hypoxia

neostigmine has been researched along with Hypoxia in 15 studies

Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
" The aim of the study is to comparison of neuromuscular blockade and reversal using cisatricurium and neostigmine with rocuronium and sugamadex on the quality of recovery from general anaesthesia for percutaneous closure of left atria appendage."9.51A comparison of neuromuscular blockade and reversal using cisatricurium and neostigmine with rocuronium and sugamadex on the quality of recovery from general anaesthesia for percutaneous closure of left atria appendage. ( Li, Q; Wu, D; Wu, J; Xie, H; Xu, M; Yao, H, 2022)
" The aim of the study is to comparison of neuromuscular blockade and reversal using cisatricurium and neostigmine with rocuronium and sugamadex on the quality of recovery from general anaesthesia for percutaneous closure of left atria appendage."5.51A comparison of neuromuscular blockade and reversal using cisatricurium and neostigmine with rocuronium and sugamadex on the quality of recovery from general anaesthesia for percutaneous closure of left atria appendage. ( Li, Q; Wu, D; Wu, J; Xie, H; Xu, M; Yao, H, 2022)
"In this single-center, experimental, randomized, controlled trial, ventilatory responses to 5-min hypoxia (oxygen saturation, 80 ± 2%) and ventilation at hyperoxic isohypercapnia (end-tidal carbon dioxide concentration, 55 mmHg) were obtained at baseline, during rocuronium-induced partial neuromuscular block (train-of-four ratio of 0."5.30Reversal of Partial Neuromuscular Block and the Ventilatory Response to Hypoxia: A Randomized Controlled Trial in Healthy Volunteers. ( Aarts, LPHJ; Boon, M; Broens, SJL; Dahan, A; Martini, CH; Niesters, M; van Velzen, M, 2019)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-199010 (66.67)18.7374
1990's2 (13.33)18.2507
2000's0 (0.00)29.6817
2010's2 (13.33)24.3611
2020's1 (6.67)2.80

Authors

AuthorsStudies
Li, Q1
Yao, H1
Wu, J1
Xu, M1
Xie, H1
Wu, D1
Broens, SJL1
Boon, M1
Martini, CH1
Niesters, M1
van Velzen, M1
Aarts, LPHJ1
Dahan, A1
Grosse-Sundrup, M1
Henneman, JP1
Sandberg, WS1
Bateman, BT1
Uribe, JV1
Nguyen, NT1
Ehrenfeld, JM1
Martinez, EA1
Kurth, T1
Eikermann, M1
ANDERS, M1
NIESCHKE, W1
DAHM, H1
TAUGNER, R1
VARAGIC, VM1
BELESLIN, DB1
YAMASHITA, K1
MORI, S1
ABE, M1
OTA, M1
NISHIGUCHI, M1
MIYAZATO, Y1
EICHBAUM, FW1
PEREIRA, CB1
ROYER, R1
LAMARCHE, M1
DALICHAMPS, P1
HELBIG, D1
Saiyed, M1
Riker, WK1
Baurain, MJ1
Hoton, F1
Dernovoi, BS1
d'Hollander, AA1
Bucher, K1
Benz-Lippold, M1
Bättig, P1
List, WF1
Harrison, GA1
Bailey, RJ1
Thomson, PG1
Coleman, AJ1
Sliom, CM1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Intraoperative Neuromuscular Blockade on Postoperative Atelectasis in Patients Undergoing Thoracic Surgery With One Lung Ventilation: Moderate vs. Deep Block[NCT03503565]118 participants (Actual)Observational2018-10-11Completed
Visualization of Regional Lung Ventilation During Neostigmine or Sugammadex Enhanced Recovery From Moderate Residual Neuromuscular Blockade in the Anaesthetized Rat Using Functional Respiratory Imaging[NCT02284412]Phase 413 participants (Actual)Interventional2014-12-31Completed
Effects of Postoperative Residual Paralysis on Costs of Hospital Care, Length of Hospitalization and Intensive Care Unit Admission Rate[NCT01718860]3,000 participants (Anticipated)Observational2011-04-30Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Atelectasis Area on Chest CT

Atelectasis on Chest CT The lung area was delineated manually. To calculate atelectasis, a region of interest was laid out that encircled the dense part of the lung, excluding large vessels. For further analysis, the lung was divided into four categories: areas with densities ranging from -1000 to -900 Hounsfield units (HU) were classified as over-aerated, from -900 to -500 HU as normally aerated, from -500 to -100 HU as poorly aerated, and from -100 to +100 HU as non-aerated (atelectasis). The proportion of non-aerated lung tissue (-100 to +100 HU) was calculated by dividing the area of the region of interest with the whole lungs. (NCT03503565)
Timeframe: 1 day after the end of surgery

Interventionpercentage of atelectasis volume (Median)
Moderate Block Group1.32
Deep Block Group1.41

Reviews

1 review available for neostigmine and Hypoxia

ArticleYear
[Cardiac arrhythmias during anesthesia: their origin and pharmacological control].
    Der Anaesthesist, 1966, Volume: 15, Issue:11

    Topics: Anesthetics; Arrhythmias, Cardiac; Catecholamines; Digitalis Glycosides; Electroshock; Heart Disease

1966

Trials

3 trials available for neostigmine and Hypoxia

ArticleYear
A comparison of neuromuscular blockade and reversal using cisatricurium and neostigmine with rocuronium and sugamadex on the quality of recovery from general anaesthesia for percutaneous closure of left atria appendage.
    Journal of cardiothoracic surgery, 2022, Aug-26, Volume: 17, Issue:1

    Topics: Anesthesia, General; Atrial Appendage; gamma-Cyclodextrins; Humans; Hypoxia; Neostigmine; Neuromuscu

2022
Reversal of Partial Neuromuscular Block and the Ventilatory Response to Hypoxia: A Randomized Controlled Trial in Healthy Volunteers.
    Anesthesiology, 2019, Volume: 131, Issue:3

    Topics: Adolescent; Adult; Anesthesia Recovery Period; Cholinesterase Inhibitors; Double-Blind Method; Elect

2019
Influence and relative sensitivities of 50-Hz and 100-Hz tetanic stimuli on subsequent tetanic fade ratios in patients receiving vecuronium.
    Anesthesia and analgesia, 1996, Volume: 82, Issue:1

    Topics: Adolescent; Adult; Atropine; Cholinesterase Inhibitors; Electric Stimulation; Evaluation Studies as

1996

Other Studies

11 other studies available for neostigmine and Hypoxia

ArticleYear
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
    BMJ (Clinical research ed.), 2012, Oct-15, Volume: 345

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema

2012
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
    BMJ (Clinical research ed.), 2012, Oct-15, Volume: 345

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema

2012
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
    BMJ (Clinical research ed.), 2012, Oct-15, Volume: 345

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema

2012
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
    BMJ (Clinical research ed.), 2012, Oct-15, Volume: 345

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema

2012
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
    BMJ (Clinical research ed.), 2012, Oct-15, Volume: 345

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema

2012
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
    BMJ (Clinical research ed.), 2012, Oct-15, Volume: 345

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema

2012
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
    BMJ (Clinical research ed.), 2012, Oct-15, Volume: 345

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema

2012
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
    BMJ (Clinical research ed.), 2012, Oct-15, Volume: 345

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema

2012
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
    BMJ (Clinical research ed.), 2012, Oct-15, Volume: 345

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema

2012
[Comparative pharmacological studies on tired, anoxemic and normal skeletal muscle].
    Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie, 1953, Volume: 217, Issue:4

    Topics: Hypoxia; Muscle, Skeletal; Muscles; Neostigmine; Physostigmine; Potassium; Strophanthins; Xanthines

1953
Comparison of adrenergic activation by anticholinesterases and by hypoxia.
    Circulation research, 1962, Volume: 11

    Topics: Adrenergic Agents; Atropine; Blood Pressure; Bretylium Compounds; Cholinesterase Inhibitors; Gallami

1962
[STUDIES ON EARLY OPERATIVE DEATHS].
    Iryo, 1963, Volume: 17

    Topics: Anesthesia; Anesthesia, General; Anesthesiology; Hypoxia; Japan; Mortality; Neostigmine; Surgical Pr

1963
EFFECT OF CRANIAL TRAUMA ON THE ELECTROCARDIOGRAM EXPERIMENTS IN GUINEA-PIGS.
    Cardiologia, 1964, Volume: 44

    Topics: Arrhythmias, Cardiac; Atropine; Brain Injuries; Craniocerebral Trauma; Electrocardiography; Ergotami

1964
[STUDY OF THE ANTICHOLINESTERASE ACTIVITY OF THE NICOTINIC ESTER OF DIETHYLAMINOETHANOL].
    Comptes rendus des seances de la Societe de biologie et de ses filiales, 1963, Volume: 157

    Topics: Amino Alcohols; Cholinesterase Inhibitors; Cholinesterases; Enzyme Inhibitors; Ethanolamines; Guinea

1963
[A CONTRIBUTION TO THE TREATMENT OF INTESTINAL PARALYSIS IN CHILDHOOD].
    Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen, 1964, Volume: 35

    Topics: Acidosis; Humans; Hypoxia; Infant; Intestinal Obstruction; Intussusception; Neostigmine; Postoperati

1964
Cholinergic and anticholinergic drug effects on survival during hypoxia: significant gender differences.
    The Journal of pharmacology and experimental therapeutics, 1993, Volume: 264, Issue:3

    Topics: Animals; Atropine; Body Temperature; Female; Hypoxia; Male; Mice; Neostigmine; Parasympatholytics; P

1993
Peak-potentialities of inspiratory musculature as disclosed by tracheal occlusion.
    Agents and actions, 1973, Volume: 3, Issue:1

    Topics: Animals; Atropine; Central Nervous System Stimulants; Diaphragm; Female; Hypercapnia; Hypoxia; Male;

1973
A heart transplantation. 4. Anaesthesia and cardio-pulmonary bypass.
    The Medical journal of Australia, 1969, Mar-29, Volume: 1, Issue:13

    Topics: Acidosis; Anesthesia, General; Anuria; Atropine; Australia; Blood Pressure; Coronary Vessels; Extrac

1969
Polycythaemic hypoxaemia and general anaesthesia. A case report.
    British journal of anaesthesia, 1966, Volume: 38, Issue:8

    Topics: Atropine; Humans; Hypoxia; Male; Middle Aged; Neostigmine; Polycythemia; Thiopental; Tubocurarine

1966