neostigmine has been researched along with Hypotension in 20 studies
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Hypotension: Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Spinal neostigmine causes analgesia in animals and humans and abolishes hypotension from spinal bupivacaine in rats." | 7.69 | Spinal neostigmine diminishes, but does not abolish, hypotension from spinal bupivacaine in sheep. ( Eisenach, JC; Rose, G; Tong, C; Xu, Z, 1996) |
| "To test whether neostigmine would alter clonidine-induced hypotension, nine chronically prepared sheep received intrathecal injections of saline or neostigmine (150, 300, 1,000 micrograms) followed in 15 min by 200 micrograms clonidine." | 7.68 | Neostigmine counteracts spinal clonidine-induced hypotension in sheep. ( Eisenach, JC; Tong, C; Williams, JS, 1993) |
| "Spinal neostigmine causes analgesia in animals and humans and abolishes hypotension from spinal bupivacaine in rats." | 3.69 | Spinal neostigmine diminishes, but does not abolish, hypotension from spinal bupivacaine in sheep. ( Eisenach, JC; Rose, G; Tong, C; Xu, Z, 1996) |
| "To test whether neostigmine would alter clonidine-induced hypotension, nine chronically prepared sheep received intrathecal injections of saline or neostigmine (150, 300, 1,000 micrograms) followed in 15 min by 200 micrograms clonidine." | 3.68 | Neostigmine counteracts spinal clonidine-induced hypotension in sheep. ( Eisenach, JC; Tong, C; Williams, JS, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (65.00) | 18.7374 |
| 1990's | 4 (20.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (5.00) | 2.80 |
| Authors | Studies |
|---|---|
| Paredes, S | 1 |
| Torres, VH | 1 |
| Chaves-Cardona, H | 1 |
| Matus, M | 1 |
| Porter, S | 1 |
| Renew, JR | 1 |
| Mathis, KW | 1 |
| Molina, PE | 1 |
| Thomas, MC | 1 |
| Erstad, BL | 1 |
| GOERRE, J | 1 |
| PANDEY, K | 1 |
| KUMAR, S | 1 |
| BADOLA, RP | 1 |
| GREENWOOD, RJ | 1 |
| TUTTLE, RS | 1 |
| CONNOR, RS | 1 |
| KREUL, W | 1 |
| ORTH, OS | 1 |
| ERDMANN, WD | 1 |
| MERCKER, H | 1 |
| ALTANA, G | 1 |
| Baraka, A | 2 |
| Goudas, LC | 1 |
| Filos, KS | 1 |
| Williams, JS | 1 |
| Tong, C | 2 |
| Eisenach, JC | 2 |
| Rose, G | 1 |
| Xu, Z | 1 |
| Fedorov, VI | 1 |
| Eldor, J | 1 |
| Hoffman, B | 1 |
| Davidson, JT | 1 |
| Molchanova, GIa | 1 |
| Voznesenskiĭ, BB | 1 |
| Vetten, KB | 1 |
| Lett, Z | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Prospective, Randomized Trial of Enteral Naloxone Versus a Traditional Bowel Regimen in Prevention of Constipation and Decreased Gastric Motility in Critically Ill Trauma Patients[NCT00799201] | Phase 4 | 3 participants (Actual) | Interventional | 2007-08-31 | Terminated (stopped due to Naloxone became unavailable due to manufacturing shortatges requiring the study to be terminated.) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 trials available for neostigmine and Hypotension
| Article | Year |
|---|---|
Safety of enteral naloxone and i.v. neostigmine when used to relieve constipation.
Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Colic; | 2003 |
[Functional peculiarities of the cardiovascular system in healthy parturients on various days of the puerperium].
Topics: Adaptation, Physiological; Adult; Cardiovascular Physiological Phenomena; Cardiovascular System; Cho | 1966 |
18 other studies available for neostigmine and Hypotension
| Article | Year |
|---|---|
An appraisal of neostigmine versus sugammadex for neuromuscular blockade reversal in patients with a prior heart transplant.
Topics: Anesthetics; Bradycardia; Heart Transplantation; Humans; Hypotension; Neostigmine; Neuromuscular Blo | 2023 |
Central acetylcholinesterase inhibition improves hemodynamic counterregulation to severe blood loss in alcohol-intoxicated rats.
Topics: Alcoholic Intoxication; Animals; Antidiuretic Hormone Receptor Antagonists; Arginine Vasopressin; Bl | 2009 |
[Influencing hypotensive states with prostigmin resulting from ganglion block with ecolid in man].
Topics: Autonomic Agents; Autonomic Nervous System; Chlorisondamine; Humans; Hypotension; Male; Neostigmine | 1957 |
NEUROMUSCULAR BLOCKING AND HYPOTENSIVE ACTIONS OF STREPTOMYCIN, AND THEIR REVERSAL.
Topics: Autonomic Nerve Block; Calcium; Chloralose; Chlorides; Dogs; Hypotension; Neostigmine; Neuromuscular | 1964 |
THE PROPER USE OF CAROTID SINUS STIMULATION.
Topics: Angina Pectoris; Arrhythmias, Cardiac; Carotid Sinus; Diagnosis; Digitalis Glycosides; Drug Therapy; | 1964 |
AN INTENSE HYPOTENSIVE RESPONSE EVOKED BY MEDULLARY STIMULATION IN THE PYRAMIDAL CAT.
Topics: Adrenal Medulla; Atropine; Cats; Electric Stimulation; Hexamethonium Compounds; Histology; Hypotensi | 1965 |
Treatment of the hypotensive states of spinal analgesia with dilute neosynephrin solution.
Topics: Analgesia; Anesthesia; Blood Pressure; Humans; Hypotension; Neostigmine | 1951 |
[Hypotension caused by d-tubocurarine; antagonistic effect of prostigmine].
Topics: Blood Pressure; Blood Pressure Determination; Curare; Hostility; Hypotension; Neostigmine; Tubocurar | 1952 |
[Hypotensive effect of prostigmine: hemodynamic study in normotensive subjects].
Topics: Blood Pressure; Hemodynamics; Humans; Hypotension; Neostigmine | 1949 |
A comparative study between diallylnortoxiferine and tubocurarine.
Topics: Adolescent; Adult; Aged; Atropine; Blood Pressure; Humans; Hypotension; Middle Aged; Neostigmine; Ne | 1967 |
Pretreatment with an intrathecal cholinergic pressor agent: is it necessary?
Topics: Anesthesia, Spinal; Animals; Blood Pressure; Clonidine; Humans; Hypotension; Neostigmine; Premedicat | 1994 |
Neostigmine counteracts spinal clonidine-induced hypotension in sheep.
Topics: Animals; Clonidine; Female; Hypotension; Injections, Spinal; Neostigmine; Sheep | 1993 |
Spinal neostigmine diminishes, but does not abolish, hypotension from spinal bupivacaine in sheep.
Topics: Analgesia; Anesthesia, Spinal; Anesthetics, Local; Animals; Blood Pressure; Bupivacaine; Hypotension | 1996 |
[The effect of activation and blockade of the renin-angiotensin system on the hypotensive activity of the cholinergic system].
Topics: Acetylcholine; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Dose-Re | 1992 |
Prolonged bradycardia and hypotension after neostigmine administration in a patient receiving atenolol.
Topics: Aged; Atenolol; Bradycardia; Drug Interactions; Female; Humans; Hypotension; Neostigmine; Pancuroniu | 1987 |
Safe reversal. 1. Atropine followed by neostigmine. An electrocardiographic study.
Topics: Adjuvants, Anesthesia; Adult; Arrhythmias, Cardiac; Atropine; Heart; Heart Rate; Humans; Hypotension | 1968 |
Anaesthesia for renal transplantation. A preliminary report.
Topics: Anesthesia; Anesthesia, Spinal; Blood Pressure Determination; Cadaver; Cyclopropanes; Ethers; Ethyl | 1970 |
Diallylnortoxiferine? Difficult to reverse.
Topics: Atropine; Humans; Hypotension; Muscle Relaxants, Central; Neostigmine | 1970 |