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neostigmine and Hyperglycemia

neostigmine has been researched along with Hyperglycemia in 16 studies

Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.

Hyperglycemia: Abnormally high BLOOD GLUCOSE level.

Research Excerpts

ExcerptRelevanceReference
" Microinjection of HgCl2 and neostigmine into the third ventricle under anesthesia caused marked hyperglycemia."7.69Hypothalamic cholinergic systems in mercuric chloride-induced hyperglycemia. ( Ikarashi, Y; Ishimaru, H; Maruyama, Y; Takahashi, A, 1994)
"We investigated the effects of intrahypothalamic or hippocampal injection of GABA receptor agonists on hyperglycemia induced by hippocampal neostigmine."7.68Intrahypothalamic, but not hippocampal, administration of muscimol suppresses hyperglycemia induced by hippocampal neostigmine in anesthetized rats. ( Hiyoshi, Y; Iguchi, A; Maeda, N; Miura, H; Nonogaki, K; Ozawa, K; Sakamoto, N; Tamagawa, T; Watanabe, G, 1993)
"We investigated the effect of GABA receptor agonists on the central nervous system (CNS)-mediated hyperglycemia induced by neostigmine or histamine in anesthetized fed rats."7.68Activation of GABAA receptor in the brain suppresses neostigmine or histamine-induced central nervous system-mediated hyperglycemia. ( Hiyoshi, Y; Iguchi, A; Li, X; Miura, H; Nonogaki, K; Ozawa, K; Sakamoto, N; Tamagawa, T; Watanabe, G, 1993)
" To determine whether brain histamine receptors are involved in cholinergic system transmission with regard to central nervous system (CNS)-mediated glucoregulation, we examined the effects of the H1 receptor antagonist pyrilamine and the H2 receptor antagonist ranitidine on neostigmine-induced hyperglycemia in anesthetized rats."7.68Role of brain histamine H1- and H2-receptors in neostigmine-induced hyperglycemia in rats. ( Hiyoshi, Y; Iguchi, A; Li, X; Nonogaki, K; Sakamoto, N; Tamagawa, T; Watanabe, G, 1992)
"We previously reported that the injection of neostigmine, an acetylcholine esterase inhibitor, into the dorsal hippocampus produced hepatic venous plasma hyperglycemia associated with an increase of epinephrine and glucagon in anesthetized fed rats."7.68Mechanism of intrahippocampal neostigmine-induced hyperglycemia in fed rats. ( Goshima, K; Iguchi, A; Ishiguro, T; Miura, H; Nonogaki, K; Sakamoto, N; Tamagawa, T; Uemura, K, 1992)
"We investigated the relationship between the hyperglycemia induced by the administration of neostigmine into the hippocampus and the hypothalamus."7.68Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine. ( Gotoh, M; Iguchi, A; Ishiguro, T; Kunoh, Y; Miura, H; Nonogaki, K; Sakamoto, N; Tamagawa, T; Uemura, K, 1991)
"We previously reported that neostigmine injected into the third cerebral ventricle stimulated adrenal secretion of epinephrine, secretion of glucagon from the pancreas, and direct neural innervation of the liver, resulting in hepatic venous plasma hyperglycemia in anesthetized fed rats."7.68Neostigmine-induced hyperglycemia is mediated by central muscarinic receptor in fed rats. ( Gotoh, M; Iguchi, A; Matsunaga, H; Miura, H; Sakamoto, N; Satake, T; Tamagawa, T; Uemura, K; Yatomi, A, 1990)
" Microinjection of HgCl2 and neostigmine into the third ventricle under anesthesia caused marked hyperglycemia."3.69Hypothalamic cholinergic systems in mercuric chloride-induced hyperglycemia. ( Ikarashi, Y; Ishimaru, H; Maruyama, Y; Takahashi, A, 1994)
"The contents of hypothalamic neurotransmitters were examined under inducement of hyperglycemia by intraventricular administration of neostigmine, after pretreatment with microwave irradiation."3.68Intraventricular injection of neostigmine increases dopaminergic and noradrenergic nerve activities: hyperglycemic effects and neurotransmitters in the hypothalamus. ( Ikarashi, Y; Ishimaru, H; Maruyama, Y; Takahashi, A, 1993)
"We investigated the effects of intrahypothalamic or hippocampal injection of GABA receptor agonists on hyperglycemia induced by hippocampal neostigmine."3.68Intrahypothalamic, but not hippocampal, administration of muscimol suppresses hyperglycemia induced by hippocampal neostigmine in anesthetized rats. ( Hiyoshi, Y; Iguchi, A; Maeda, N; Miura, H; Nonogaki, K; Ozawa, K; Sakamoto, N; Tamagawa, T; Watanabe, G, 1993)
"We investigated the effect of GABA receptor agonists on the central nervous system (CNS)-mediated hyperglycemia induced by neostigmine or histamine in anesthetized fed rats."3.68Activation of GABAA receptor in the brain suppresses neostigmine or histamine-induced central nervous system-mediated hyperglycemia. ( Hiyoshi, Y; Iguchi, A; Li, X; Miura, H; Nonogaki, K; Ozawa, K; Sakamoto, N; Tamagawa, T; Watanabe, G, 1993)
" To determine whether brain histamine receptors are involved in cholinergic system transmission with regard to central nervous system (CNS)-mediated glucoregulation, we examined the effects of the H1 receptor antagonist pyrilamine and the H2 receptor antagonist ranitidine on neostigmine-induced hyperglycemia in anesthetized rats."3.68Role of brain histamine H1- and H2-receptors in neostigmine-induced hyperglycemia in rats. ( Hiyoshi, Y; Iguchi, A; Li, X; Nonogaki, K; Sakamoto, N; Tamagawa, T; Watanabe, G, 1992)
"We previously reported that the injection of neostigmine, an acetylcholine esterase inhibitor, into the dorsal hippocampus produced hepatic venous plasma hyperglycemia associated with an increase of epinephrine and glucagon in anesthetized fed rats."3.68Mechanism of intrahippocampal neostigmine-induced hyperglycemia in fed rats. ( Goshima, K; Iguchi, A; Ishiguro, T; Miura, H; Nonogaki, K; Sakamoto, N; Tamagawa, T; Uemura, K, 1992)
"We investigated the relationship between the hyperglycemia induced by the administration of neostigmine into the hippocampus and the hypothalamus."3.68Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine. ( Gotoh, M; Iguchi, A; Ishiguro, T; Kunoh, Y; Miura, H; Nonogaki, K; Sakamoto, N; Tamagawa, T; Uemura, K, 1991)
"We previously reported that neostigmine injected into the third cerebral ventricle stimulated adrenal secretion of epinephrine, secretion of glucagon from the pancreas, and direct neural innervation of the liver, resulting in hepatic venous plasma hyperglycemia in anesthetized fed rats."3.68Neostigmine-induced hyperglycemia is mediated by central muscarinic receptor in fed rats. ( Gotoh, M; Iguchi, A; Matsunaga, H; Miura, H; Sakamoto, N; Satake, T; Tamagawa, T; Uemura, K; Yatomi, A, 1990)
"Neostigmine was injected into the third cerebral ventricle of bilaterally adrenodemedullectomized (ADMX) rats, while somatostatin and insulin were administered intravenously."1.28Effects of adrenergic blockers on central nervous system-mediated hyperglycemia in fed rats. ( Gotoh, M; Iguchi, A; Kunoh, Y; Mano, T; Miura, H; Nonogaki, K; Sakamoto, N; Tamagawa, T; Uemura, K, 1992)
"Neostigmine was injected into the third cerebral ventricle and hepatic venous plasma glucose, glucagon, insulin, and epinephrine were measured."1.28Central nervous system control of glycogenolysis and gluconeogenesis in fed and fasted rat liver. ( Iguchi, A; Kawahara, H; Kunoh, Y; Miura, H; Sakamoto, N; Tamagawa, T; Uemura, K; Yatomi, A, 1989)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19903 (18.75)18.7374
1990's11 (68.75)18.2507
2000's2 (12.50)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
BRAEUNLICH, H1
de Andrade, IS1
Gonzalez, JC1
Hirata, AE1
Carneiro, G1
Amado, D1
Cavalheiro, EA1
Dolnikoff, MS1
Takahashi, A2
Ishimaru, H2
Ikarashi, Y2
Maruyama, Y2
Ozawa, K2
Miura, H7
Tamagawa, T8
Hiyoshi, Y3
Nonogaki, K6
Maeda, N1
Watanabe, G3
Sakamoto, N9
Iguchi, A9
Brito, NA1
Brito, MN1
Kettelhut, IC1
Migliorini, RH1
Li, X2
Gotoh, M5
Takagi, J1
Mori, S1
Yatoh, M1
Hirooka, Y1
Yamanouchi, K1
Smythe, GA2
Kunoh, Y3
Uemura, K5
Mano, T1
Edwards, SR1
Ishiguro, T2
Goshima, K1
Yatomi, A3
Matsunaga, H2
Satake, T1
Kawahara, H1
Honmura, A1
Yanase, M1

Other Studies

16 other studies available for neostigmine and Hyperglycemia

ArticleYear
[THE ALTERATION OF THE HYPERGLYCEMIC EFFECT OF MORPHINE BY OPIATE ANTAGONISTS AND OTHER DRUGS].
    Acta biologica et medica Germanica, 1964, Volume: 12

    Topics: Chemical and Drug Induced Liver Injury; Dimercaprol; Ergotamine; Hepatitis A; Hyperglycemia; Insulin

1964
Central but not peripheral glucoprivation is impaired in monosodium glutamate-treated rats.
    Neuroscience letters, 2006, May-01, Volume: 398, Issue:1-2

    Topics: Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus; Blood Glucose; Corticotropin-Releasing H

2006
Intraventricular injection of neostigmine increases dopaminergic and noradrenergic nerve activities: hyperglycemic effects and neurotransmitters in the hypothalamus.
    Neuroscience letters, 1993, Jun-25, Volume: 156, Issue:1-2

    Topics: 3,4-Dihydroxyphenylacetic Acid; Acetylcholine; Animals; Blood Glucose; Cerebral Ventricles; Choline;

1993
Hypothalamic cholinergic systems in mercuric chloride-induced hyperglycemia.
    Brain research bulletin, 1994, Volume: 34, Issue:1

    Topics: Animals; Blood Glucose; Extracellular Space; Hyperglycemia; Hypothalamus; Male; Mercuric Chloride; M

1994
Intrahypothalamic, but not hippocampal, administration of muscimol suppresses hyperglycemia induced by hippocampal neostigmine in anesthetized rats.
    Life sciences, 1993, Volume: 53, Issue:25

    Topics: Analysis of Variance; Animals; Baclofen; Blood Glucose; Epinephrine; Hepatic Veins; Hippocampus; Hyp

1993
Intra-ventromedial hypothalamic injection of cholinergic agents induces rapid hyperglycemia, hyperlactatemia and gluconeogenesis activation in fed, conscious rats.
    Brain research, 1993, Oct-29, Volume: 626, Issue:1-2

    Topics: Adrenal Medulla; Animals; Carbachol; Food; Gluconeogenesis; Hyperglycemia; Hypothalamic Area, Latera

1993
Activation of GABAA receptor in the brain suppresses neostigmine or histamine-induced central nervous system-mediated hyperglycemia.
    Life sciences, 1993, Volume: 53, Issue:9

    Topics: Animals; Baclofen; Brain; Central Nervous System; Histamine; Histamine Antagonists; Hyperglycemia; I

1993
Octreotide-induced suppression of the hyperglycemic response to neostigmine or bombesin: relationship to hypothalamic noradrenergic drive.
    Brain research, 2001, Nov-16, Volume: 919, Issue:1

    Topics: Animals; Blood Glucose; Bombesin; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Hormo

2001
Effects of adrenergic blockers on central nervous system-mediated hyperglycemia in fed rats.
    Metabolism: clinical and experimental, 1992, Volume: 41, Issue:5

    Topics: Adrenalectomy; Animals; Central Nervous System; Hepatic Veins; Hyperglycemia; Injections, Intraventr

1992
Suppression of central noradrenergic neuronal activity inhibits hyperglycemia.
    The American journal of physiology, 1992, Volume: 263, Issue:5 Pt 1

    Topics: Animals; Blood Glucose; Brain; Deoxyglucose; Hyperglycemia; Hypothalamus, Middle; Injections, Intrav

1992
Role of brain histamine H1- and H2-receptors in neostigmine-induced hyperglycemia in rats.
    Life sciences, 1992, Volume: 51, Issue:12

    Topics: Animals; Blood Glucose; Brain; Hyperglycemia; Male; Neostigmine; Pyrilamine; Ranitidine; Rats; Rats,

1992
Mechanism of intrahippocampal neostigmine-induced hyperglycemia in fed rats.
    Neuroendocrinology, 1992, Volume: 55, Issue:1

    Topics: Animals; Epinephrine; Glucagon; Hippocampus; Hyperglycemia; Hypothalamus, Middle; Insulin; Insulin S

1992
Hyperglycemia induced by hippocampal administration of neostigmine is suppressed by intrahypothalamic atropine.
    Neuropharmacology, 1991, Volume: 30, Issue:10

    Topics: Animals; Atropine; Blood Glucose; Hexamethonium Compounds; Hippocampus; Hyperglycemia; Hypothalamus;

1991
Neostigmine-induced hyperglycemia is mediated by central muscarinic receptor in fed rats.
    Brain research, 1990, Jan-22, Volume: 507, Issue:2

    Topics: Adrenergic Fibers; Animals; Atropine; Brain; Hyperglycemia; Injections, Intraventricular; Male; Neos

1990
Central nervous system control of glycogenolysis and gluconeogenesis in fed and fasted rat liver.
    Metabolism: clinical and experimental, 1989, Volume: 38, Issue:12

    Topics: Adrenal Medulla; Animals; Blood Glucose; Cerebral Ventricles; Epinephrine; Fasting; Glucagon; Glucon

1989
Relative contributions of the nervous system and hormones to CNS-mediated hyperglycemia.
    The American journal of physiology, 1988, Volume: 255, Issue:6 Pt 1

    Topics: Adrenal Medulla; Animals; Blood Glucose; Cerebral Ventricles; Epinephrine; Glucagon; Hyperglycemia;

1988