neostigmine and Complication, Postoperative
neostigmine has been researched along with Complication, Postoperative in 173 studies
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Research Excerpts
Excerpt | Relevance | Reference |
---|---|---|
"For patients accepted colon carcinoma surgery, neostigmine did not significantly reduce the incidence of POD, postoperative mortality and postoperative hospital stay, while it indeed reduced the extubating time, PACU time and the incidence of POPCs." | 9.51 | The effect of neostigmine on postoperative delirium after colon carcinoma surgery: a randomized, double-blind, controlled trial. ( Bi, Y; Deng, X; Dong, R; Guo, Y; Lin, X; Lin, Y; Liu, F; Wang, B, 2022) |
"This study aimed to assess the effects of sugammadex and neostigmine/atropine on postoperative cognitive dysfunction (POCD) in adult patients after elective surgery." | 9.24 | Effect of sugammadex versus neostigmine/atropine combination on postoperative cognitive dysfunction after elective surgery. ( Batistaki, C; Kostopanagiotou, G; Lyrakos, G; Matsota, P; Riga, M; Zafeiropoulou, F, 2017) |
" The current trial was aimed to compare between sugammadex and neostigmine concerning the recovery time from neuromuscular blockade." | 9.24 | A comparison of sugammadex and neostigmine for reversal of rocuronium-induced neuromuscular blockade in children. ( Ammar, AS; Kasemy, ZA; Mahmoud, KM, 2017) |
" In this randomized, double-blind, placebo-controlled study of 113 healthy children who had received mivacurium as part of a standardized anesthetic regimen, we compared the incidence of postoperative complications after spontaneous recovery and after the use of neostigmine-glycopyrrolate or edrophonium-atropine." | 9.08 | Effect of antagonism of mivacurium-induced neuromuscular block on postoperative emesis in children. ( McCulloch, DA; Safavi, FZ; Tan, TS; Watcha, MF; White, PF, 1995) |
"Neostigmine may increase postoperative nausea and vomiting." | 9.08 | Reversal of neuromuscular blockade with neostigmine has no effect on the incidence or severity of postoperative nausea and vomiting. ( Halonen, P; Hovorka, J; Korttila, K; Nelskylä, K; Paatero, H; Sarvela, J; Soikkeli, A; Yli-Hankala, A, 1997) |
"A double-blind and randomized clinical trial, which included 48 patients with postoperative intestinal paralysis on the third day after laparotomy, demonstrated no difference between treatment with ceruletide (0." | 9.06 | Ceruletide and neostigmine in postoperative intestinal paralysis. A double-blind clinical controlled trial. ( Hagen, K; Madsen, PV; Olsen, O, 1986) |
" The authors hypothesized that the choice of neuromuscular blockade reversal (neostigmine vs." | 7.96 | Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER): A Multicenter Matched Cohort Analysis. ( Bardia, A; Bartels, K; Bash, LD; Colquhoun, DA; Dubovoy, TZ; Kheterpal, S; Mathis, MR; McCormick, PJ; Saager, L; Schonberger, RB; Shah, NJ; Shanks, AM; Soto, RG; Vaughn, MT, 2020) |
"Prospective observational series of consecutive patients scheduled for laparoscopic bariatric surgery in whom neuromuscular blockade was reverted with sugammadex were compared with a historical matched cohort of patients reverted with neostigmines." | 7.80 | Postoperative respiratory outcomes in laparoscopic bariatric surgery: comparison of a prospective group of patients whose neuromuscular blockade was reverted with sugammadex and a historical one reverted with neostigmine. ( Cabrera, A; Camprubí, I; Ferreres, E; Llauradó, S; Sabaté, A, 2014) |
"Starting the early intake of nutrition with neostigmine in the postoperative period reduced the postoperative ileus and increased the healing of colon anastomoses (Tab." | 7.77 | The effect of neostigmine on postoperative ileus and the healing of colon anastomoses. ( Durgun, V; Ekci, B; Emirleroglu, M, 2011) |
" Sugammadex exhibits advantages over indirect reversal agent acetylcholinesterase inhibitor neostigmine with less adverse effects." | 5.72 | Sugammadex reversal of muscle relaxant blockade provided less Post-Anesthesia Care Unit adverse effects than neostigmine/glycopyrrolate. ( Chang, HC; Lee, MJ; Lee, SO; Liu, SY; Wong, CS, 2022) |
" Sugammadex reversal of neuromuscular blockade is rapid and complete, and there appear to be fewer postoperative complications than with neostigmine." | 5.51 | Comparison of the effects of neostigmine and sugammadex on postoperative residual curarization and postoperative pulmonary complications by means of diaphragm and lung ultrasonography: a study protocol for prospective double-blind randomized controlled tr ( Chen, Y; Yi, J; Zhang, YG; Zhang, YL, 2022) |
"For patients accepted colon carcinoma surgery, neostigmine did not significantly reduce the incidence of POD, postoperative mortality and postoperative hospital stay, while it indeed reduced the extubating time, PACU time and the incidence of POPCs." | 5.51 | The effect of neostigmine on postoperative delirium after colon carcinoma surgery: a randomized, double-blind, controlled trial. ( Bi, Y; Deng, X; Dong, R; Guo, Y; Lin, X; Lin, Y; Liu, F; Wang, B, 2022) |
"Post-operative ileus is common after abdominal surgeries." | 5.51 | Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation. ( Balakrishnan, B; Hong, JC; Petersen, PC; Vitola, B, 2019) |
"We concluded that sugammadex is more effective at reducing the incidence of PPCs including pneumonia, atelectasis, NIV and reintubation compared with neostigmine." | 5.41 | Postoperative pulmonary complications after sugammadex reversal of neuromuscular blockade: a systematic review and meta-analysis with trial sequential analysis. ( Liang, P; Liu, HM; Yu, H; Zuo, YD, 2023) |
"The incidence of postoperative nausea and vomiting (PONV) in PACU was higher in neostigmine-reversed than sugammadex-reversed patients (21." | 5.40 | Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: sugammadex, neostigmine or no reversal. ( De Mel, A; Falke, L; Gillies, E; Greenaway, M; Johnston, F; Ledowski, T; Phillips, M; Tiong, WS, 2014) |
"Neostigmine has been used in some cases of refractory constipation in critically ill adults." | 5.37 | Neostigmine in the treatment of refractory constipation in critically ill children. ( Botrán, M; García, A; González, R; López-Herce, J; Solana, MJ; Urbano, J, 2011) |
"This study aimed to assess the effects of sugammadex and neostigmine/atropine on postoperative cognitive dysfunction (POCD) in adult patients after elective surgery." | 5.24 | Effect of sugammadex versus neostigmine/atropine combination on postoperative cognitive dysfunction after elective surgery. ( Batistaki, C; Kostopanagiotou, G; Lyrakos, G; Matsota, P; Riga, M; Zafeiropoulou, F, 2017) |
" The current trial was aimed to compare between sugammadex and neostigmine concerning the recovery time from neuromuscular blockade." | 5.24 | A comparison of sugammadex and neostigmine for reversal of rocuronium-induced neuromuscular blockade in children. ( Ammar, AS; Kasemy, ZA; Mahmoud, KM, 2017) |
"Neostigmine may increase postoperative nausea and vomiting." | 5.08 | Reversal of neuromuscular blockade with neostigmine has no effect on the incidence or severity of postoperative nausea and vomiting. ( Halonen, P; Hovorka, J; Korttila, K; Nelskylä, K; Paatero, H; Sarvela, J; Soikkeli, A; Yli-Hankala, A, 1997) |
" In this randomized, double-blind, placebo-controlled study of 113 healthy children who had received mivacurium as part of a standardized anesthetic regimen, we compared the incidence of postoperative complications after spontaneous recovery and after the use of neostigmine-glycopyrrolate or edrophonium-atropine." | 5.08 | Effect of antagonism of mivacurium-induced neuromuscular block on postoperative emesis in children. ( McCulloch, DA; Safavi, FZ; Tan, TS; Watcha, MF; White, PF, 1995) |
" morphine 100 microg, but with a high incidence of nausea and vomiting." | 5.08 | The efficacy of intrathecal neostigmine, intrathecal morphine, and their combination for post-cesarean section analgesia. ( Chin, YJ; Chung, CJ; Kim, JS; Park, HS, 1998) |
"A double-blind and randomized clinical trial, which included 48 patients with postoperative intestinal paralysis on the third day after laparotomy, demonstrated no difference between treatment with ceruletide (0." | 5.06 | Ceruletide and neostigmine in postoperative intestinal paralysis. A double-blind clinical controlled trial. ( Hagen, K; Madsen, PV; Olsen, O, 1986) |
"In 2020, the Sugammadex vs Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER) study provided evidence for the first time that use of sugammadex is associated with fewer postoperative pulmonary complications than use of neostigmine." | 4.31 | How robust are the STRONGER and STIL-STRONGER studies? ( Blobner, M; Hunter, JM; Ulm, K, 2023) |
"Gastrografin and combined use of gastrografin and neostigmine are effective and viable methods for postoperative ileus cases." | 4.31 | The efficacy and results of medical treatment in postoperative ileus. ( Alkan, S; Cakir, M; Duyan, AG; Sentiurk, M; Varman, A, 2023) |
" The authors hypothesized that the choice of neuromuscular blockade reversal (neostigmine vs." | 3.96 | Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER): A Multicenter Matched Cohort Analysis. ( Bardia, A; Bartels, K; Bash, LD; Colquhoun, DA; Dubovoy, TZ; Kheterpal, S; Mathis, MR; McCormick, PJ; Saager, L; Schonberger, RB; Shah, NJ; Shanks, AM; Soto, RG; Vaughn, MT, 2020) |
"Inappropriate dosing of neostigmine for antagonism of neuromuscular blockade has been associated with postoperative pulmonary complications." | 3.88 | Implementation of a new strategy to improve the peri-operative management of neuromuscular blockade and its effects on postoperative pulmonary complications. ( Agarwala, AV; Chitilian, HV; Doney, AB; Eikermann, M; Houle, TT; Ng, PY; Ramachandran, SK; Rudolph, MI; Timm, FP, 2018) |
"Prospective observational series of consecutive patients scheduled for laparoscopic bariatric surgery in whom neuromuscular blockade was reverted with sugammadex were compared with a historical matched cohort of patients reverted with neostigmines." | 3.80 | Postoperative respiratory outcomes in laparoscopic bariatric surgery: comparison of a prospective group of patients whose neuromuscular blockade was reverted with sugammadex and a historical one reverted with neostigmine. ( Cabrera, A; Camprubí, I; Ferreres, E; Llauradó, S; Sabaté, A, 2014) |
"Neostigmine reversal did not affect oxygenation but was associated with increased atelectasis." | 3.80 | Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study. ( Doran, ME; Eikermann, M; Hoang, AH; Igumenshcheva, A; MacDonald, T; Malviya, SA; Meyer, MJ; Sasaki, N; Stanislaus, AB, 2014) |
"Starting the early intake of nutrition with neostigmine in the postoperative period reduced the postoperative ileus and increased the healing of colon anastomoses (Tab." | 3.77 | The effect of neostigmine on postoperative ileus and the healing of colon anastomoses. ( Durgun, V; Ekci, B; Emirleroglu, M, 2011) |
" The most likely cause was the return of muscle paralysis after the apparent antagonism of tubocurarine by neostigmine (recurarization)." | 3.65 | Renal failure and postoperative respiratory failure: recurarization? ( Cullen, DJ; Miller, RD, 1976) |
"Residual neuromuscular block has been associated with postoperative pulmonary complications." | 2.94 | Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery. ( Aziz, MF; Higgins, JR; Tekkali, P; Togioka, BM; Treggiari, MM; Yanez, D, 2020) |
"Neostigmine was intravenously injected in the post-anesthesia care unit (PACU) according to the train-of-four ratio (TOFR) T4/T1." | 2.94 | The effects of neostigmine on postoperative cognitive function and inflammatory factors in elderly patients - a randomized trial. ( Deng, C; Feng, Y; Sun, D; Sun, Z; Yang, L; Zhu, B, 2020) |
"Median [interquartile range (IQR)] atelectasis area was 9." | 2.90 | Effects of neuromuscular block reversal with sugammadex versus neostigmine on postoperative respiratory outcomes after major abdominal surgery: a randomized-controlled trial. ( Alday, E; Alvarez, C; Mata, E; Muñoz, M; Planas, A, 2019) |
"Electroacupuncture combined with acupoint injection has a satisfied therapeutic effect for treatment of EPISBO." | 2.75 | [Clinical observation on electroacupuncture combined with acupoint injection for treatment of early postoperative inflammatory intestinal obstruction]. ( Ding, KY; Guan, J; Shen, LP, 2010) |
"Monitoring for pain, sedation, postoperative nausea/vomiting, dizziness, and pruritus was performed by anesthesiologists blinded to the study allocation." | 2.71 | Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine. ( Acharya, A; Kumar, P; Pan, AK; Rudra, A, 2005) |
" Peripherally acting acetylcholinesterase inhibitors such as neostigmine should then only be administered when indicated and dosed based on results of the train-of-four ratio." | 2.66 | The effects of acetylcholinesterase inhibitors on morbidity after general anesthesia and surgery. ( Eikermann, M; Schaefer, MS; Shay, D; Wongtangman, K, 2020) |
"Neostigmine, 0." | 2.66 | Neostigmine in postoperative intestinal paralysis. A double-blind, clinical, controlled trial. ( Myrhöj, T; Olsen, O; Wengel, B, 1988) |
" Patients treated with Ceruletide (n = 30, dosage of Ceruletide 2 ng/kg/min." | 2.65 | [Treatment of intestinal atony following gynecologic operations. Study on the effectiveness and tolerance of ceruletide]. ( Baur, M; Heinrich, D; Kubli, F; Schmid, H; Schulz-Wendtland, R; von Fournier, D, 1984) |
"Patients with obstructive sleep apnea (OSA) may be at higher risk of complications related to the use of NMBD." | 2.58 | Postoperative complications with neuromuscular blocking drugs and/or reversal agents in obstructive sleep apnea patients: a systematic review. ( Chung, F; Hafeez, KR; Nagappa, M; Singh, M; Tuteja, A; Wong, DT; Wong, J, 2018) |
"Even small degrees of residual neuromuscular blockade, i." | 2.55 | [Residual neuromuscular blockade]. ( Fuchs-Buder, T; Schmartz, D, 2017) |
"The management of neuromuscular blocks in day case surgery requests a comprehensive approach that should include an adequate dosing of the muscle relaxant, quantitative objective monitoring, and a sufficient and appropriate reversal." | 2.50 | Management of neuromuscular blockade in ambulatory patients. ( Schreiber, JU, 2014) |
" Sugammadex exhibits advantages over indirect reversal agent acetylcholinesterase inhibitor neostigmine with less adverse effects." | 1.72 | Sugammadex reversal of muscle relaxant blockade provided less Post-Anesthesia Care Unit adverse effects than neostigmine/glycopyrrolate. ( Chang, HC; Lee, MJ; Lee, SO; Liu, SY; Wong, CS, 2022) |
" Inappropriate dosing of neostigmine can lead to post-operative respiratory complications." | 1.62 | Identifying high dose neostigmine as a risk factor for post-operative respiratory complications: a case-control study. ( Al-Zarah, M; Drzymalski, DM; Hall III, RR; Quraishi, SA; Ranjan, S, 2021) |
"Post-operative ileus is common after abdominal surgeries." | 1.51 | Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation. ( Balakrishnan, B; Hong, JC; Petersen, PC; Vitola, B, 2019) |
"Complete avoidance of residual neuromuscular blockade (RNMB) during the postoperative period has not yet been achieved in current anesthesia practice." | 1.51 | Usefulness of intra-operative neuromuscular blockade monitoring and reversal agents for postoperative residual neuromuscular blockade: a retrospective observational study. ( Domenech, G; Fornari, GG; García Guzzo, ME; Kampel, MA; Novas, DS; Terrasa, SA, 2019) |
" We tested whether a protocol for the management of neuromuscular block that specified appropriate dosing and optimal neostigmine reversal was associated with a reduction in postoperative residual neuromuscular block." | 1.48 | Management of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine. ( Bhananker, SM; Cain, KC; Ng, IC; Thilen, SR; Treggiari, MM, 2018) |
"Neostigmine treatment was required for 1 patient in the intensive care unit setting, and 3 patients were managed conservatively without complications." | 1.46 | The Potentially Fatal Ogilvie's Syndrome in Lateral Transpsoas Access Surgery: A Multi-Institutional Experience with 2930 Patients. ( Beckman, JM; Januszewski, J; Kanter, AS; Keem, SK; Oskuian, RJ; Smith, W; Taylor, W; Uribe, JS, 2017) |
"Neostigmine was associated with a dose-dependent increase in the risk of postoperative respiratory complications (OR, 1." | 1.42 | Dose-dependent Association between Intermediate-acting Neuromuscular-blocking Agents and Postoperative Respiratory Complications. ( Diaz-Gil, D; Eikermann, M; Farhan, HN; Kurth, T; Ladha, KS; McLean, DJ, 2015) |
"The incidence of postoperative nausea and vomiting (PONV) in PACU was higher in neostigmine-reversed than sugammadex-reversed patients (21." | 1.40 | Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: sugammadex, neostigmine or no reversal. ( De Mel, A; Falke, L; Gillies, E; Greenaway, M; Johnston, F; Ledowski, T; Phillips, M; Tiong, WS, 2014) |
"Neostigmine has been used in some cases of refractory constipation in critically ill adults." | 1.37 | Neostigmine in the treatment of refractory constipation in critically ill children. ( Botrán, M; García, A; González, R; López-Herce, J; Solana, MJ; Urbano, J, 2011) |
" It is suggested that the dosage of anticholinergic agents given with neostigmine could be reduced in elderly patients in comparison to that in younger patients." | 1.27 | Antagonism of neuromuscular block in the elderly. A comparison of atropine and glycopyrronium in a mixture with neostigmine. ( Mirakhur, RK, 1985) |
"Ampullary stenosis was confirmed in all patients who subsequently underwent sphincteroplasty." | 1.26 | Duodenoscopy and endoscopic pancreatography in patients with postive morphine prostigmine tests. ( Capobianco, AG; Frager, SH; Gregg, JA; McCartney, AJ; Milano, AF; Santoro, BT; Taddeo, AE, 1977) |
"Neostigmine may produce this effect by causing contractions of the gut musculature or by vasoconstriction of the blood vessels to the suture line, resulting in local ischaemia." | 1.25 | Effect of neostigmine on integrity of ileorectal anastomoses. ( Bell, CM; Lewis, CB, 1968) |
Research
Studies (173)
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 66 (38.15) | 18.7374 |
1990's | 17 (9.83) | 18.2507 |
2000's | 11 (6.36) | 29.6817 |
2010's | 45 (26.01) | 24.3611 |
2020's | 34 (19.65) | 2.80 |
Authors
Authors | Studies |
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Beltran, RJ | 1 |
Mpody, C | 1 |
Nafiu, OO | 1 |
Tobias, JD | 1 |
Carron, M | 2 |
Tessari, I | 1 |
Linassi, F | 2 |
Ranjan, S | 1 |
Hall III, RR | 1 |
Al-Zarah, M | 1 |
Quraishi, SA | 1 |
Drzymalski, DM | 1 |
Zhang, YG | 1 |
Chen, Y | 2 |
Zhang, YL | 1 |
Yi, J | 1 |
Chang, HC | 1 |
Liu, SY | 1 |
Lee, MJ | 1 |
Lee, SO | 1 |
Wong, CS | 1 |
Yu, Y | 1 |
Wang, H | 1 |
Bao, Q | 1 |
Zhang, T | 1 |
Chen, B | 1 |
Ding, J | 1 |
Colquhoun, DA | 2 |
Vaughn, MT | 2 |
Bash, LD | 2 |
Janda, A | 1 |
Shah, N | 1 |
Ghaferi, A | 1 |
Sjoding, M | 1 |
Mentz, G | 1 |
Kheterpal, S | 2 |
Sharma, A | 1 |
Campos, JH | 1 |
Togioka, BM | 2 |
Schenning, KJ | 1 |
Liu, F | 1 |
Lin, X | 1 |
Lin, Y | 1 |
Deng, X | 2 |
Guo, Y | 2 |
Wang, B | 1 |
Dong, R | 1 |
Bi, Y | 1 |
Traeger, L | 1 |
Hall, TD | 1 |
Bedrikovetski, S | 2 |
Kroon, HM | 2 |
Dudi-Venkata, NN | 2 |
Moore, JW | 2 |
Sammour, T | 2 |
Yang, JL | 1 |
Chen, KB | 1 |
Shen, ML | 1 |
Hsu, WT | 1 |
Lai, YW | 1 |
Hsu, CM | 1 |
Blobner, M | 1 |
Hunter, JM | 2 |
Ulm, K | 1 |
Suleiman, A | 1 |
Munoz-Acuna, R | 1 |
Azimaraghi, O | 1 |
Houle, TT | 2 |
Chen, G | 1 |
Rupp, S | 1 |
Witt, AS | 1 |
Azizi, BA | 1 |
Ahrens, E | 1 |
Shay, D | 2 |
Wongtangman, K | 2 |
Wachtendorf, LJ | 1 |
Tartler, TM | 1 |
Eikermann, M | 9 |
Schaefer, MS | 2 |
Sidebotham, D | 1 |
Frampton, C | 1 |
Yu, H | 2 |
Zuo, Y | 1 |
Xu, Z | 1 |
Zhao, D | 1 |
Yue, J | 1 |
Liu, L | 1 |
Huang, J | 1 |
Liang, P | 2 |
Liu, H | 1 |
Luo, R | 1 |
Cao, S | 1 |
Zheng, B | 1 |
Ye, L | 1 |
Zhang, W | 1 |
Tamburini, E | 1 |
Ieppariello, G | 1 |
Liu, HM | 1 |
Zuo, YD | 1 |
Díaz-Cambronero, Ó | 1 |
Mazzinari, G | 1 |
Errando, CL | 1 |
Garutti, I | 1 |
Gurumeta, AA | 1 |
Serrano, AB | 1 |
Esteve, N | 1 |
Montañes, MV | 1 |
Neto, AS | 1 |
Hollmann, MW | 1 |
Schultz, MJ | 1 |
Argente Navarro, MP | 1 |
Alkan, S | 1 |
Cakir, M | 1 |
Sentiurk, M | 1 |
Varman, A | 1 |
Duyan, AG | 1 |
Ji, Y | 1 |
Yuan, H | 1 |
Zhang, X | 1 |
Wu, F | 1 |
Tang, W | 1 |
Lu, Z | 1 |
Huang, C | 1 |
Bai, YX | 1 |
Han, JJ | 1 |
Liu, J | 2 |
Li, X | 1 |
Xu, ZZ | 1 |
Lv, Y | 1 |
Liu, KX | 1 |
Wu, QP | 1 |
Domenech, G | 1 |
Kampel, MA | 1 |
García Guzzo, ME | 1 |
Novas, DS | 1 |
Terrasa, SA | 1 |
Fornari, GG | 1 |
Petersen, PC | 1 |
Balakrishnan, B | 1 |
Vitola, B | 1 |
Hong, JC | 1 |
Korkmaz, MO | 1 |
Sayhan, H | 1 |
Guven, M | 1 |
Scheffenbichler, FT | 1 |
Rudolph, MI | 2 |
Friedrich, S | 1 |
Althoff, FC | 1 |
Xu, X | 1 |
Spicer, AC | 1 |
Patrocínio, M | 1 |
Ng, PY | 2 |
Deng, H | 1 |
Anderson, TA | 1 |
Oh, TK | 2 |
Ryu, JH | 1 |
Nam, S | 1 |
Oh, AY | 2 |
Yanez, D | 1 |
Aziz, MF | 1 |
Higgins, JR | 1 |
Tekkali, P | 1 |
Treggiari, MM | 2 |
Dubovoy, TZ | 1 |
Shah, NJ | 1 |
Shanks, AM | 1 |
Mathis, MR | 1 |
Soto, RG | 1 |
Bardia, A | 1 |
Bartels, K | 1 |
McCormick, PJ | 1 |
Schonberger, RB | 1 |
Saager, L | 2 |
Leslie, K | 1 |
Min, BH | 1 |
Song, IA | 1 |
Jeon, YT | 1 |
Zhu, B | 1 |
Sun, D | 1 |
Yang, L | 1 |
Sun, Z | 1 |
Feng, Y | 1 |
Deng, C | 1 |
Brull, SJ | 1 |
Murphy, GS | 1 |
Ledowski, T | 2 |
Szabó-Maák, Z | 1 |
Loh, PS | 1 |
Turlach, BA | 1 |
Yang, HS | 1 |
de Boer, HD | 1 |
Asztalos, L | 1 |
Shariffuddin, II | 1 |
Chan, L | 1 |
Fülesdi, B | 1 |
Piskin, O | 1 |
Altinsoy, B | 1 |
Cimencan, M | 1 |
Aydin, BG | 1 |
Okyay, D | 1 |
Kucukosman, G | 1 |
Tascilar, O | 1 |
Sarikaya, S | 1 |
Ayoglu, H | 1 |
Choi, ES | 1 |
Koo, BW | 1 |
Hwang, JW | 1 |
Han, JW | 1 |
Seo, KS | 1 |
Ahn, SH | 1 |
Jeong, WJ | 1 |
Fuchs-Buder, T | 3 |
Schmartz, D | 1 |
Batistaki, C | 1 |
Riga, M | 1 |
Zafeiropoulou, F | 1 |
Lyrakos, G | 1 |
Kostopanagiotou, G | 1 |
Matsota, P | 1 |
Belcher, AW | 1 |
Leung, S | 1 |
Cohen, B | 1 |
Yang, D | 1 |
Mascha, EJ | 1 |
Turan, A | 1 |
Ruetzler, K | 1 |
Chitilian, HV | 1 |
Timm, FP | 1 |
Agarwala, AV | 1 |
Doney, AB | 1 |
Ramachandran, SK | 1 |
Hafeez, KR | 1 |
Tuteja, A | 1 |
Singh, M | 1 |
Wong, DT | 1 |
Nagappa, M | 1 |
Chung, F | 1 |
Wong, J | 1 |
Thilen, SR | 1 |
Ng, IC | 1 |
Cain, KC | 1 |
Bhananker, SM | 1 |
Alday, E | 1 |
Muñoz, M | 1 |
Planas, A | 1 |
Mata, E | 1 |
Alvarez, C | 1 |
Xia, R | 1 |
Kachru, N | 1 |
Tuazon, DM | 1 |
Bostan, F | 1 |
Fuentes, A | 1 |
Meyer, MJ | 3 |
Bateman, BT | 2 |
Kurth, T | 3 |
Donati, F | 1 |
Kalb, A | 1 |
von Haefen, C | 1 |
Sifringer, M | 1 |
Tegethoff, A | 1 |
Paeschke, N | 1 |
Kostova, M | 1 |
Feldheiser, A | 1 |
Spies, CD | 1 |
Della Rocca, G | 1 |
Pompei, L | 1 |
Pagan DE Paganis, C | 1 |
Tesoro, S | 1 |
Mendola, C | 1 |
Boninsegni, P | 1 |
Tempia, A | 1 |
Manstretta, S | 1 |
Zamidei, L | 1 |
Gratarola, A | 1 |
Murabito, P | 1 |
Fuggiano, L | 1 |
DI Marco, P | 1 |
Baraka, A | 2 |
Falke, L | 1 |
Johnston, F | 1 |
Gillies, E | 1 |
Greenaway, M | 1 |
De Mel, A | 1 |
Tiong, WS | 1 |
Phillips, M | 1 |
Llauradó, S | 1 |
Sabaté, A | 1 |
Ferreres, E | 1 |
Camprubí, I | 1 |
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Utsunomiya, H | 1 |
Nakazawa, T | 1 |
Uragami, T | 1 |
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Aitkenhead, AR | 2 |
Sher, MH | 1 |
Mathews, PA | 1 |
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Baur, M | 1 |
Schmid, H | 1 |
Schulz-Wendtland, R | 1 |
Heinrich, D | 1 |
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Punt-van Manen, JA | 1 |
Müller, H | 1 |
Kalenda, Z | 1 |
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Allwright, GT | 1 |
von Sommoggy, S | 2 |
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Fraunhofer, B | 1 |
Ruwart, MJ | 1 |
Klepper, MS | 1 |
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Shorten, GD | 1 |
Merk, H | 1 |
Sieber, T | 1 |
Boeke, AJ | 2 |
Smith, I | 1 |
Williams, PI | 1 |
Watcha, MF | 2 |
Safavi, FZ | 1 |
McCulloch, DA | 1 |
Tan, TS | 1 |
White, PF | 2 |
de Lange, JJ | 1 |
van Druenen, B | 1 |
Langemeijer, JJ | 1 |
Litman, RS | 1 |
Younan, MM | 1 |
Patt, RB | 1 |
Ward, DS | 1 |
Huang, CH | 1 |
Wang, MJ | 1 |
Susetio, L | 1 |
Cherng, YG | 1 |
Shi, JJ | 1 |
Chen, YA | 1 |
Chiu, WH | 1 |
Orlando, E | 1 |
Finelli, F | 1 |
Colla, M | 1 |
Giotto, E | 1 |
Terragni, P | 1 |
Olivero, G | 1 |
Figueredo, E | 1 |
Sánchez, G | 1 |
Pérez, J | 1 |
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Korttila, K | 1 |
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Yli-Hankala, A | 1 |
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Heinkelmann, W | 1 |
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Gutstein Feldman, D | 1 |
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Clinical Trials (33)
Trial Overview
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Comparison of the Effects of Neostigmine and Sugammadex on Postoperative Residual Curarization and Postoperative Pulmonary Complications Detected by Diaphragm and Lung Ultrasonography: A Study Protocol for Prospective Double-blind Randomized Controlled Tr[NCT05040490] | 414 participants (Anticipated) | Interventional | 2021-08-31 | Not yet recruiting | |||
The Effect of Sugammadex Versus Neostigmine on Postoperative Pulmonary Complications in Patients 70 Years or Older and Scheduled for 3 Hour or Longer Surgery-A Randomized Controlled Trial[NCT02861131] | Phase 4 | 200 participants (Actual) | Interventional | 2017-01-24 | Completed | ||
Diaphragm Ultrasound to Evaluate the Antagonistic Effect of Sugammadex on Rocuronium After Liver Surgery in Patients With Different Liver Child-Pugh Grades[NCT05028088] | Phase 4 | 99 participants (Anticipated) | Interventional | 2021-07-01 | Recruiting | ||
Comparison Sugammadex With Neostigmine in Laryngeal Microsurgery.[NCT02330172] | 44 participants (Actual) | Interventional | 2014-05-31 | Completed | |||
Comparison of the Effect of Continuous Infusion and Bolus Doses of Rocuronium During Anesthesia for Lumbal Discectomy on Muscle Strength and Quality of Patient Recovery[NCT04236050] | 80 participants (Actual) | Interventional | 2015-12-31 | Completed | |||
Comparison of General Anesthesia With Use of Muscle Relaxation and General Anesthesia Without Muscle Relaxation on Recovery of Muscle Strength of the Patients[NCT04760912] | 60 participants (Anticipated) | Interventional | 2020-04-01 | Enrolling by invitation | |||
PACU or ICU for Postoperative Care After Major Thoracic and Abdominal Surgery:a Prospective Randomized Clinical Trial[NCT05046925] | 18,000 participants (Anticipated) | Observational | 2021-10-01 | Not yet recruiting | |||
Validation of the REPS Prediction Tool to Improve Quality of Perioperative Care[NCT03585400] | 101,510 participants (Actual) | Observational | 2018-06-29 | Completed | |||
Importance of Understanding Provider Variability in the Use of Neuromuscular Blocking Drugs and Reversal Agents[NCT03585348] | 265,537 participants (Actual) | Observational | 2018-06-29 | Completed | |||
Effect of Type II Diabetes Mellitus With Neuropathy on the Clinical Use of Rocuronium: A Pharmacodynamic Modelling Study[NCT03737942] | 60 participants (Anticipated) | Observational | 2018-11-15 | Recruiting | |||
Incidence and Severity of Residual Neuromuscular Blockade With Application of a Protocol for Paralysis and Neostigmine Reversal of Rocuronium[NCT02660398] | Phase 4 | 78 participants (Actual) | Interventional | 2016-01-31 | Completed | ||
Electromyographic Activity of the Diaphragm and of the Rectus Abdominis and Intercostal Muscles During Neostigmine, Sugammadex, or Neostigmine-sugammadex Enhanced Recovery After Neuromuscular Blockade With Rocuronium. A Randomised Controlled Study in Heal[NCT02403063] | Phase 4 | 18 participants (Actual) | Interventional | 2015-09-30 | Completed | ||
The Effect of Sugammadex Versus Neostigmine During Neuromuscular Blockade Reversal in Outpatient Surgeries - An Evaluation of Clinical and Associated Health Care Cost[NCT03579589] | Phase 1 | 40 participants (Actual) | Interventional | 2018-08-15 | Completed | ||
Assessment of Residual Paralysis in Patients Who Receive Mini-dose Atracurium During Supraglottic Airway Insertion[NCT02673853] | 337 participants (Actual) | Observational | 2016-02-29 | Completed | |||
The Effectiveness of Neostigmine on the Recovery of Rocuronium-Induced Neuromuscular Blockade: A Comparison Between Partial Dose and TOF Ratio-Based Adjustment Dose[NCT03058263] | Phase 1/Phase 2 | 66 participants (Actual) | Interventional | 2016-10-31 | Completed | ||
A Randomized, Blinded-assessor, Single Center Study to Determine if Administration of Sugammadex, When Used to Reverse Deep Neuromuscular Blockade (NMB) After Open Abdominal Surgery, Impacts Hospital Efficiency[NCT02860507] | Phase 4 | 50 participants (Actual) | Interventional | 2016-08-31 | Completed | ||
Comparing Deep Neuromuscular Block and Moderate Neuromuscular Block in Patients Undergoing Laparoscopic Gynaecological Surgeries: Impact on Surgical Satisfaction of Operating Conditions and Patient Satisfaction[NCT02794714] | Phase 4 | 0 participants (Actual) | Interventional | 2016-06-30 | Withdrawn (stopped due to unresolved budget issues) | ||
The VivaSight Double Lumen Tube Versus Conventional Double Lumen Tube in Thoracic Surgical Patients[NCT03690284] | 50 participants (Actual) | Interventional | 2019-06-19 | Completed | |||
Effects of Postoperative Residual Paralysis on Costs of Hospital Care, Length of Hospitalization and Intensive Care Unit Admission Rate[NCT01718860] | 3,000 participants (Anticipated) | Observational | 2011-04-30 | Active, not recruiting | |||
Residual Curarization and Its Incidence at Tracheal Extubation in China[NCT01871064] | 1,571 participants (Actual) | Observational | 2012-12-31 | Completed | |||
The Effect of Intraoperative Neuromuscular Blockade on Postoperative Atelectasis in Patients Undergoing Thoracic Surgery With One Lung Ventilation: Moderate vs. Deep Block[NCT03503565] | 118 participants (Actual) | Observational | 2018-10-11 | Completed | |||
Combined General and Spinal Anesthesia vs. Combined General and Spinal Anesthesia With Neuromuscular Blockade for Operative Repair of Hip Fractures[NCT03226080] | Phase 4 | 0 participants (Actual) | Interventional | 2017-07-19 | Withdrawn (stopped due to Study terminated with IRB on 20Feb2019 due to lack of enrollment.) | ||
Sugammadex Versus Neostigmine in Pediatric Day-case Cancer Surgery[NCT03996655] | Phase 4 | 80 participants (Anticipated) | Interventional | 2019-06-30 | Not yet recruiting | ||
Recovery Profiles After c Spine Surgery: With or Without Dexmedetomidine as an Anesthetic Adjuvant[NCT02819089] | 100 participants (Anticipated) | Interventional | 2016-05-31 | Recruiting | |||
Comparison of Two Different Anesthetic Techniques on Incidence of Postoperative Delirium in Cancer Patients After Laparoscopic Surgery in Trendelenburg Position: A Prospective Randomized Clinical Trial[NCT03572517] | 65 participants (Actual) | Interventional | 2017-09-01 | Completed | |||
The Effect of Low Flow Anesthesia on Postoperative Emergence Agitation in Rhinoplasty: A Randomized, Controlled Trial[NCT05601674] | 76 participants (Actual) | Interventional | 2022-11-04 | Completed | |||
Visualization of Regional Lung Ventilation During Neostigmine or Sugammadex Enhanced Recovery From Moderate Residual Neuromuscular Blockade in the Anaesthetized Rat Using Functional Respiratory Imaging[NCT02284412] | Phase 4 | 13 participants (Actual) | Interventional | 2014-12-31 | Completed | ||
Optimal Dose of Combination of Rocuronium and Cisatracurium: A Randomized Double-blinded Clinical Trial[NCT02495038] | 81 participants (Actual) | Interventional | 2014-03-31 | Completed | |||
A Prospective Randomized Control Trial of The Effectiveness of Entereg as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery[NCT02742181] | Phase 3 | 14 participants (Actual) | Interventional | 2015-12-02 | Terminated (stopped due to terminated due to lack of enrollment) | ||
A Randomized Trial of Alvimopan for the Reduction of Ileus After Long Posterior Spinal Fusion[NCT02218190] | 31 participants (Actual) | Interventional | 2014-08-31 | Completed | |||
A Prospective Randomized Control Trial of The Effectiveness of Alvimopan as a Rescue Treatment of Postoperative Ileus Following Colorectal Surgery[NCT04405037] | Phase 4 | 58 participants (Anticipated) | Interventional | 2020-08-01 | Recruiting | ||
Measurement Of GI Myoelectric Activity In Patients At Risk For Or Who Have A Post-Operative Ileus (POI) - Monitoring/ Recording GI Myoelectric Activity For Early Detection of A POI[NCT02673671] | 150 participants (Anticipated) | Observational | 2016-02-29 | Recruiting | |||
A Prospective Evaluation of an Anesthesia Protocol to Reduce Post-operative and Post-discharge Nausea and Vomiting in a High Risk Orthognathic Surgery Population[NCT01592708] | 233 participants (Actual) | Interventional | 2012-06-30 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trial Outcomes
Hospital Length of Stay
Defined as the number of days between hospital admission and discharge (NCT02861131)
Timeframe: Length of hospitalization, an average of 1 week
Intervention | days (Mean) |
---|---|
Sugammadex | 4.0 |
Neostigmine | 4.5 |
Number of Participants Diagnosed With a National Surgical Quality Improvement Program (NSQIP) Defined Respiratory Complication
pneumonia, unplanned re-intubation for any reason other than a return trip to the operating room, and ventilator times greater than 48 hours - excluding operating room time (NCT02861131)
Timeframe: Length of hospitalization, an average of 1 week
Intervention | Participants (Count of Participants) |
---|---|
Sugammadex | 4 |
Neostigmine | 2 |
Number of Participants With a Postoperative Pulmonary Complication
A composite outcome which includes any of the following: postoperative pneumonia, aspiration pneumonitis, atelectasis, pneumothorax, desaturation/hypoxemia, upper airway obstruction, or acute respiratory insufficiency (NCT02861131)
Timeframe: Length of hospitalization, an average of 1 week
Intervention | Participants (Count of Participants) |
---|---|
Sugammadex | 33 |
Neostigmine | 40 |
Number of Participants With Hospital Readmission Within 30 Days
The proportion of patients that require hospital readmission for any cause within 30 days of hospital discharge (NCT02861131)
Timeframe: Length of hospitalization plus 30 days post-discharge
Intervention | Participants (Count of Participants) |
---|---|
Sugammadex | 5 |
Neostigmine | 15 |
Number of Participants With Residual Neuromuscular Blockade in the PACU
Residual neuromuscular blockade will be defined as a train-of-four ratio < 0.9 taken within 5 minutes of subject arrival in the PACU (NCT02861131)
Timeframe: 1 day
Intervention | Participants (Count of Participants) |
---|---|
Sugammadex | 9 |
Neostigmine | 46 |
PACU Phase 1 Recovery Time
Defined as duration of time required to attain pain control and stable respiratory, haemodynamic, and neurological status (NCT02861131)
Timeframe: 1 day
Intervention | minutes (Mean) |
---|---|
Sugammadex | 97.3 |
Neostigmine | 110.0 |
Recovery Time From Neuromuscular Blockade
We measured recovery time ffrom the injection of neostigmine or sugammadex to TOF ratio 0.9 (NCT02330172)
Timeframe: from the injection of neostigmine or sugammadex up to 30 minutes
Intervention | minute (Mean) |
---|---|
Rocuronium 0.45 - Neostigmine | 9.9 |
Rocuronium 0.9 - Sugammadex | 2.1 |
Laryngoscopic Score
"Definitions for evaluation of Laryngoscopycondition.~: Easy = jaw relaxed, no resistance to blade insertion, fair = jaw not fully relaxed, slight resistance to blade insertion, difficult = poor jaw relaxation, active resistance of the patient to laryngoscopy.~Variables Excellent Good Poor" (NCT02330172)
Timeframe: At the beginning of surgery, the surgeon rated the laryngoscopy condition
Intervention | Participants (Count of Participants) | ||
---|---|---|---|
Difficult | Fair | Easy | |
Rocuronium 0.45 - Neostigmine | 1 | 11 | 9 |
Rocuronium 0.9 - Sugammadex | 0 | 0 | 19 |
Number of Patients Who Experience Postoperative Nausea and Vomiting, Post-operative Pain, and Post-operative Complications
(NCT02860507)
Timeframe: through discharge from hospital, average of 72 hours
Intervention | Participants (Count of Participants) |
---|---|
Neostigmine + Glycopyrrolate | 8 |
Sugammadex | 10 |
Operating Room (OR) Turnover Time When Using Sugammadex Instead of Combination of Neostigmine and Glycopyrrolate.
(NCT02860507)
Timeframe: through start of next surgery, average of 2 hours
Intervention | Minutes (Mean) |
---|---|
Neostigmine + Glycopyrrolate | 49.7 |
Sugammadex | 49.45 |
Number of Participants Requiring Flexible Fiberoptic Bronchoscopy
The number of participants requiring flexible fiberoptic bronchoscopy during double-lumen tube intubation for a single lung ventilation. (NCT03690284)
Timeframe: Intraoperative, within the time the double lumen was in the trachea
Intervention | Participants (Count of Participants) |
---|---|
Conventional Double Lumen Tube | 25 |
VivaSight Double Lumen Tube | 7 |
Number of Participants With Malposition
The number of participants with malposition of double lumen tube for a single lung intubation (NCT03690284)
Timeframe: Intraoperative, within the time the double lumen was in the trachea
Intervention | Participants (Count of Participants) |
---|---|
Conventional Double Lumen Tube | 12 |
VivaSight Double Lumen Tube | 4 |
The Intubation Time
The time required to place double lumen endotracheal tube for a single lung intubation (NCT03690284)
Timeframe: Intraoperative, time to successfully intubate patient.
Intervention | seconds (Median) |
---|---|
Conventional Double Lumen Tube | 156 |
VivaSight Double Lumen Tube | 54 |
Atelectasis Area on Chest CT
Atelectasis on Chest CT The lung area was delineated manually. To calculate atelectasis, a region of interest was laid out that encircled the dense part of the lung, excluding large vessels. For further analysis, the lung was divided into four categories: areas with densities ranging from -1000 to -900 Hounsfield units (HU) were classified as over-aerated, from -900 to -500 HU as normally aerated, from -500 to -100 HU as poorly aerated, and from -100 to +100 HU as non-aerated (atelectasis). The proportion of non-aerated lung tissue (-100 to +100 HU) was calculated by dividing the area of the region of interest with the whole lungs. (NCT03503565)
Timeframe: 1 day after the end of surgery
Intervention | percentage of atelectasis volume (Median) |
---|---|
Moderate Block Group | 1.32 |
Deep Block Group | 1.41 |
Additional Rescue Doses Per Hour Ratio.
Additional Rescue Doses Per Hour Ratio is the number per hour of addition of rescue dose administrated with 10% of initial NMBAs dose. The formula is {(Addition number + 1 / Anesthetic time) x 60}. (NCT02495038)
Timeframe: Intraoperative, an average of 3 hours.
Intervention | ratio (Mean) |
---|---|
Intubating Dose, Group I | 1.43455 |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 1.21014 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 0.82128 |
Anesthetic Time
Time from induction to recovery of anesthesia, asessed up to 3 hours. (NCT02495038)
Timeframe: Intraoperative, an average 4 hours.
Intervention | Minute (Mean) |
---|---|
Intubating Dose, Group I | 163.0 |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 159.9 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 161.4 |
Bispectral Index
"The BIS monitor provides a single dimensionless number, which ranges from 0 (equivalent to EEG silence) to 100. A BIS value between 40 and 60 indicates an appropriate level for general anesthesia, as recommended by the manufacturer.~Before induction of anesthesia, bispectral index was measured for baseline. And after injection of NMBAs, bispectral index was measured at 10 min." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
Intervention | BIS score (Mean) |
---|---|
Intubating Dose, Group I | 46.0 |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 46.1 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 44.3 |
Body Temperature
"Before induction of anesthesia, body temperature was measured for baseline by oral temperature probe.~And after injection of NMBAs, non invasive blood pressure was measured at 10 min by esophageal temperature probe." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
Intervention | Celcius degree (Mean) |
---|---|
Intubating Dose, Group I | 36.3 |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 36.3 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 36.3 |
Duration 25% of Neuromuscular Blocking Agents(NMBAs)
Time from administration of initial NMBAs to Train-of-four (TOF) ratio >25%, assessed up to 2 hours during general anesthesia. (NCT02495038)
Timeframe: Intraoperative, an average of 1 hours
Intervention | Minute (Mean) |
---|---|
Intubating Dose, Group I | 51.3 |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 47.9 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 39.4 |
Onset of Neuromuscular Blocking Agents(NMBAs)
Time from administration of initial NMBAs to Train-of-four (TOF) ratio=0, assessed up to 15 minutes during general anesthesia. (NCT02495038)
Timeframe: Intraoperative, an average of 5 minutes
Intervention | Second (Mean) |
---|---|
Intubating Dose, Group I | 212.8 |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 230.1 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 399.3 |
Operation Time
Time from skin incision to wound dressing assessed up to 8 hours. (NCT02495038)
Timeframe: Intraoperative, an average of 3 hours.
Intervention | Minute (Mean) |
---|---|
Intubating Dose, Group I | 151.8 |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 147.0 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 145.9 |
Peripheral Oxygen Saturation
"Before induction of anesthesia, peripheral oxygen saturation was measured for baseline.~And after injection of NMBAs, peripheral oxygen saturation was measured at 10 min." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
Intervention | Percentage (Mean) |
---|---|
Intubating Dose, Group I | 100 |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 99.9 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 100 |
Recovery Index of Neuromuscular Blocking Agents(NMBAs)
Time from TOF ratio 25% to 75%, assessed up to 1 hour during general anesthesia. (NCT02495038)
Timeframe: Intraoperative, an average of 20 minutes
Intervention | Minute (Mean) |
---|---|
Intubating Dose, Group I | 15.9 |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 16.2 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 14.1 |
Non Invasive Blood Pressure,
"Before induction of anesthesia, non invasive blood pressure was measured for baseline.~And after injection of NMBAs, non invasive blood pressure was measured at 10 min." (NCT02495038)
Timeframe: Before and after induction of anesthesia, an average 10 min.
Intervention | mmHg (Mean) | |
---|---|---|
Systolic pressure | Diastolic pressure | |
10% Reduction of Combination of Esmeron® and Nimbex®, Group S | 128.3 | 76.7 |
20% Reduction of Combination of Esmeron® and Nimbex®, Group L | 128.4 | 74.8 |
Intubating Dose, Group I | 128.3 | 75.6 |
Complications
All adverse events (NCT02742181)
Timeframe: 30 days
Intervention | Number of AEs (Number) |
---|---|
Alvimopan Group | 4 |
Control Group | 6 |
Hospital Length of Stay
Date of surgery until discharge (NCT02742181)
Timeframe: up to 30 days
Intervention | Days (Median) |
---|---|
Alvimopan Group | 9 |
Control Group | 8.5 |
Number of Readmissions
Any readmissions within 30 days of surgery (NCT02742181)
Timeframe: 30 days
Intervention | Number of readmissions (Number) |
---|---|
Alvimopan Group | 0 |
Control Group | 0 |
Number of Reoperations
Any reoperations within 30 days of surgery (NCT02742181)
Timeframe: 30 days
Intervention | Number of reoperations (Number) |
---|---|
Alvimopan Group | 0 |
Control Group | 0 |
Complications and Adverse Event
Number of patients with complication/adverse event. (NCT02218190)
Timeframe: 14 days or until hospital discharge, which ever occurs first
Intervention | Participants (Count of Participants) |
---|---|
Alvimopan | 0 |
Placebo - Sugar Pill | 0 |
Length of Hospital Stay
To determine the effect of alvimopan on overall length of hospital stay in patients undergoing PSF. (NCT02218190)
Timeframe: 14 days or until hospital discharge whichever occurs first
Intervention | Hours (Mean) |
---|---|
Alvimopan | 122.5 |
Placebo - Sugar Pill | 117.2 |
Recovery of Bowel Function
To determine the effect of alvimopan on the recovery of bowel function as determined by time to first bowel movement in patients undergoing posterior spinal fusion. The effect size calculated may guide a larger, multicenter randomized controlled study. Time was measured from wound closure to bowel movement. (NCT02218190)
Timeframe: 14 days or until hospital discharge whichever occurs first
Intervention | Hours (Mean) |
---|---|
Alvimopan | 43.2 |
Placebo - Sugar Pill | 34.0 |
Hospital Length of Stay
Anesthesia start time determined from anesthesia portion of the medical record. Time at which discharge order was placed will serve as time of discharge. (NCT01592708)
Timeframe: Anesthesia start time to placement of hospital discharge order - average 26 - 28 hours
Intervention | hours (Median) |
---|---|
Intervention Cohort | 26.4 |
Comparison Cohort | 28.2 |
Post-discharge Nausea
To be assessed based on patient diary completed daily for 1 week following discharge to home from the hospital (NCT01592708)
Timeframe: 1 week from discharge from hospital
Intervention | percentage of subjects with PDN (Number) |
---|---|
Intervention Cohort | 72 |
Comparison Cohort | 60 |
Post-discharge Vomiting
(NCT01592708)
Timeframe: 1 week post discharge
Intervention | percentage of subjects with PDV (Number) |
---|---|
Intervention Cohort | 22 |
Comparison Cohort | 29 |
Post-operative Nausea
End of surgery time determined by anesthesia portion of the medical record. PONV to be assessed by review of surgeons' and nurses' notes in the medical record as well as through review of patient diaries. Vomiting constitutes a safety issue and, as such, associated adverse events will be noted. (NCT01592708)
Timeframe: End of surgery to discharge from hospital
Intervention | percentage of subjects with PON (Number) |
---|---|
Intervention Cohort | 24 |
Comparison Cohort | 70 |
Post-operative Vomiting
(NCT01592708)
Timeframe: End of surgery to discharge from hospital
Intervention | percentage of subjects with POV (Number) |
---|---|
Intervention Cohort | 11 |
Comparison Cohort | 28 |
Reviews
21 reviews available for neostigmine and Complication, Postoperative
Article | Year |
---|---|
Sugammadex compared with neostigmine in reducing postoperative pulmonary complications in older patients: a meta-analysis.
Topics: Aged; Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blockade; Neuromuscular Nondepol | 2022 |
Sugammadex for reversing neuromuscular blockages after lung surgery: A systematic review and meta-analysis.
Topics: Humans; Length of Stay; Lung; Neostigmine; Neuromuscular Blockade; Postoperative Complications; Suga | 2022 |
Superiority of sugammadex in preventing postoperative pulmonary complications.
Topics: Humans; Neostigmine; Neuromuscular Blockade; Pneumonia; Postoperative Complications; Respiratory Ins | 2023 |
Reversal of neuromuscular block with sugammadex compared with neostigmine and postoperative pulmonary complications in obese patients: meta-analysis and trial sequential analysis.
Topics: Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blockade; Postoperative Complications; | 2023 |
Postoperative pulmonary complications after sugammadex reversal of neuromuscular blockade: a systematic review and meta-analysis with trial sequential analysis.
Topics: Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blockade; Neuromuscular Blocking Agent | 2023 |
Sugammadex Is Associated With Reduced Pulmonary Complications in Patients With Respiratory Dysfunction.
Topics: Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blockade; Pleural Effusion; Postoperat | 2023 |
Sugammadex Reduced the Incidence of Postoperative Pulmonary Complications in Susceptible Patients Identified by ARISCAT Risk Index: Systematic Review and Meta-analysis.
Topics: Humans; Incidence; Neostigmine; Neuromuscular Blockade; Postoperative Complications; Pulmonary Atele | 2023 |
The effects of acetylcholinesterase inhibitors on morbidity after general anesthesia and surgery.
Topics: Anesthesia, General; Cardiovascular System; Cholinesterase Inhibitors; General Surgery; Humans; Morb | 2020 |
[Residual neuromuscular blockade].
Topics: Anesthesia Recovery Period; Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Incidenc | 2017 |
[Residual neuromuscular blockade].
Topics: Anesthesia Recovery Period; Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Incidenc | 2017 |
[Residual neuromuscular blockade].
Topics: Anesthesia Recovery Period; Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Incidenc | 2017 |
[Residual neuromuscular blockade].
Topics: Anesthesia Recovery Period; Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Incidenc | 2017 |
[Residual neuromuscular blockade].
Topics: Anesthesia Recovery Period; Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Incidenc | 2017 |
[Residual neuromuscular blockade].
Topics: Anesthesia Recovery Period; Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Incidenc | 2017 |
[Residual neuromuscular blockade].
Topics: Anesthesia Recovery Period; Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Incidenc | 2017 |
[Residual neuromuscular blockade].
Topics: Anesthesia Recovery Period; Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Incidenc | 2017 |
[Residual neuromuscular blockade].
Topics: Anesthesia Recovery Period; Delayed Emergence from Anesthesia; gamma-Cyclodextrins; Humans; Incidenc | 2017 |
Postoperative complications with neuromuscular blocking drugs and/or reversal agents in obstructive sleep apnea patients: a systematic review.
Topics: Humans; Neostigmine; Neuromuscular Blocking Agents; Parasympathomimetics; Postoperative Complication | 2018 |
Systematic scoping review of enhanced recovery protocol recommendations targeting return of gastrointestinal function after colorectal surgery.
Topics: Bisacodyl; Chewing Gum; Colonic Diseases; Humans; Ileus; Lactulose; Neostigmine; Piperidines; Postop | 2020 |
Residual paralysis: a real problem or did we invent a new disease?
Topics: Anesthesia Recovery Period; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Neostigmine; Neu | 2013 |
Residual paralysis: a real problem or did we invent a new disease?
Topics: Anesthesia Recovery Period; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Neostigmine; Neu | 2013 |
Residual paralysis: a real problem or did we invent a new disease?
Topics: Anesthesia Recovery Period; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Neostigmine; Neu | 2013 |
Residual paralysis: a real problem or did we invent a new disease?
Topics: Anesthesia Recovery Period; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Neostigmine; Neu | 2013 |
Residual paralysis: a real problem or did we invent a new disease?
Topics: Anesthesia Recovery Period; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Neostigmine; Neu | 2013 |
Residual paralysis: a real problem or did we invent a new disease?
Topics: Anesthesia Recovery Period; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Neostigmine; Neu | 2013 |
Residual paralysis: a real problem or did we invent a new disease?
Topics: Anesthesia Recovery Period; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Neostigmine; Neu | 2013 |
Residual paralysis: a real problem or did we invent a new disease?
Topics: Anesthesia Recovery Period; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Neostigmine; Neu | 2013 |
Residual paralysis: a real problem or did we invent a new disease?
Topics: Anesthesia Recovery Period; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Neostigmine; Neu | 2013 |
Management of neuromuscular blockade in ambulatory patients.
Topics: Ambulatory Surgical Procedures; Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blocka | 2014 |
[Muscle relaxants in ambulatory anesthesia].
Topics: Ambulatory Surgical Procedures; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; Intubation, | 2008 |
Pharmacological management of postoperative ileus.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal; | 2009 |
[Indications and clinical use of sugammadex].
Topics: Algorithms; Androstanols; Anesthesia Recovery Period; Clinical Trials, Phase III as Topic; Contraind | 2009 |
[Sugammadex: something new to improve patient safety or simply a gadget?].
Topics: Androstanols; Anesthesia Recovery Period; Atracurium; Cost-Benefit Analysis; Drug Approval; Electrod | 2009 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Postoperative ileus: etiologies and interventions.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Decompression, Surgical; Early Ambulation; Gastrointestinal | 2003 |
Anaesthesia and bowel surgery.
Topics: Analgesics, Opioid; Anesthesia; Anesthesia, Conduction; Anesthetics; Animals; Carbon Dioxide; Gastro | 1984 |
Anaesthesia for bowel surgery.
Topics: Analgesia; Analgesics, Opioid; Anesthesia, Conduction; Anesthesia, General; Anesthetics; Carbon Diox | 1984 |
Omitting antagonism of neuromuscular block: effect on postoperative nausea and vomiting and risk of residual paralysis. A systematic review.
Topics: Cholinesterase Inhibitors; Humans; Muscle Weakness; Neostigmine; Neuromuscular Blocking Agents; Post | 1999 |
Omitting antagonism of neuromuscular block: effect on postoperative nausea and vomiting and risk of residual paralysis. A systematic review.
Topics: Cholinesterase Inhibitors; Humans; Muscle Weakness; Neostigmine; Neuromuscular Blocking Agents; Post | 1999 |
Omitting antagonism of neuromuscular block: effect on postoperative nausea and vomiting and risk of residual paralysis. A systematic review.
Topics: Cholinesterase Inhibitors; Humans; Muscle Weakness; Neostigmine; Neuromuscular Blocking Agents; Post | 1999 |
Omitting antagonism of neuromuscular block: effect on postoperative nausea and vomiting and risk of residual paralysis. A systematic review.
Topics: Cholinesterase Inhibitors; Humans; Muscle Weakness; Neostigmine; Neuromuscular Blocking Agents; Post | 1999 |
Trials
32 trials available for neostigmine and Complication, Postoperative
Article | Year |
---|---|
Comparison of the effects of neostigmine and sugammadex on postoperative residual curarization and postoperative pulmonary complications by means of diaphragm and lung ultrasonography: a study protocol for prospective double-blind randomized controlled tr
Topics: Aged; Delayed Emergence from Anesthesia; Diaphragm; Double-Blind Method; Humans; Lung; Neostigmine; | 2022 |
Sugammadex Versus Neostigmine for Neuromuscular Block Reversal and Postoperative Pulmonary Complications in Patients Undergoing Resection of Lung Cancer.
Topics: Adult; Atropine Derivatives; Cholinesterase Inhibitors; Humans; Lung; Lung Neoplasms; Neostigmine; N | 2022 |
The effect of neostigmine on postoperative delirium after colon carcinoma surgery: a randomized, double-blind, controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Carcinoma; Colon; Delirium; Double-Blind Method; Humans; Middle Aged | 2022 |
An educational intervention to reduce the incidence of postoperative residual curarisation: a cluster randomised crossover trial in patients undergoing general anaesthesia.
Topics: Anesthesia, General; Cross-Over Studies; Delayed Emergence from Anesthesia; Humans; Neostigmine; Neu | 2023 |
Does sugammadex decrease the severity of agitation and complications in pediatric patients undergoing adenotonsillectomy?
Topics: Adenoidectomy; Adolescent; Anesthesia, General; Atropine; Child; Child, Preschool; Cough; Double-Bli | 2019 |
Randomised controlled trial of sugammadex or neostigmine for reversal of neuromuscular block on the incidence of pulmonary complications in older adults undergoing prolonged surgery.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Delayed Emergence from Anesthesia; Double-Blind | 2020 |
The effects of neostigmine on postoperative cognitive function and inflammatory factors in elderly patients - a randomized trial.
Topics: Aged; Cholinesterase Inhibitors; Cognition; Humans; Neostigmine; Neuromuscular Blockade; Neuromuscul | 2020 |
Reversal of residual neuromuscular block with neostigmine or sugammadex and postoperative pulmonary complications: a prospective, randomised, double-blind trial in high-risk older patients.
Topics: Aged; Aged, 80 and over; Australia; Cholinesterase Inhibitors; Double-Blind Method; Female; Geriatri | 2021 |
Comparison of reversal with neostigmine of low-dose rocuronium vs. reversal with sugammadex of high-dose rocuronium for a short procedure.
Topics: Adult; Aged; Anesthesia Recovery Period; Anesthesia, General; Attitude of Health Personnel; Dose-Res | 2017 |
Effect of sugammadex versus neostigmine/atropine combination on postoperative cognitive dysfunction after elective surgery.
Topics: Adult; Atropine; Cognitive Dysfunction; Double-Blind Method; Elective Surgical Procedures; Female; g | 2017 |
Effects of neuromuscular block reversal with sugammadex versus neostigmine on postoperative respiratory outcomes after major abdominal surgery: a randomized-controlled trial.
Topics: Abdomen; Aged; Female; Humans; Male; Middle Aged; Neostigmine; Neuromuscular Blockade; Postoperative | 2019 |
A comparison of sugammadex and neostigmine for reversal of rocuronium-induced neuromuscular blockade in children.
Topics: Abdomen; Androstanols; Anesthesia Recovery Period; Anesthesia, General; Atropine; Child; Child, Pres | 2017 |
[Clinical observation on electroacupuncture combined with acupoint injection for treatment of early postoperative inflammatory intestinal obstruction].
Topics: Acupuncture Points; Adult; Aged; Aged, 80 and over; Combined Modality Therapy; Electroacupuncture; F | 2010 |
Antagonism of cisatracurium and rocuronium block at a tactile train-of-four count of 2: should quantitative assessment of neuromuscular function be mandatory?
Topics: Adolescent; Adult; Aged; Androstanols; Anesthesia Recovery Period; Atracurium; Cholinesterase Inhibi | 2004 |
Caudal additives in pediatrics: a comparison among midazolam, ketamine, and neostigmine coadministered with bupivacaine.
Topics: Anesthesia Recovery Period; Anesthesia, Caudal; Anesthesia, General; Anesthetics, Intravenous; Anest | 2005 |
[Treatment of intestinal atony following gynecologic operations. Study on the effectiveness and tolerance of ceruletide].
Topics: Blood Pressure; Ceruletide; Clinical Trials as Topic; Constipation; Defecation; Female; Gastrointest | 1984 |
[Drug treatment of postoperative intestinal atony].
Topics: Adult; Aged; Ceruletide; Dihydroergotamine; Female; Gastrointestinal Diseases; Gastrointestinal Moti | 1981 |
Perioperative train-of-four monitoring and residual curarization.
Topics: Adult; Anesthesia Recovery Period; Anesthetics, Inhalation; Anesthetics, Intravenous; Cholinesterase | 1995 |
Effect of antagonism of mivacurium-induced neuromuscular block on postoperative emesis in children.
Topics: Anesthesia Recovery Period; Atropine; Child; Double-Blind Method; Edrophonium; Glycopyrrolate; Human | 1995 |
Effect of antagonizing residual neuromuscular block by neostigmine and atropine on postoperative vomiting.
Topics: Adolescent; Adult; Aged; Ambulatory Surgical Procedures; Anesthesia, General; Atropine; Female; Huma | 1994 |
Comparison of the combined effects of atropine and neostigmine with atropine and edrophonium on the occurrence of postoperative nausea and vomiting.
Topics: Adult; Atropine; Chi-Square Distribution; Double-Blind Method; Drug Therapy, Combination; Edrophoniu | 1993 |
[A double-blind study of neostigmine versus placebo in paralytic ileus as a result of surgical interventions].
Topics: Administration, Intranasal; Adult; Aged; Analysis of Variance; Cholecystectomy; Double-Blind Method; | 1994 |
Reversal of neuromuscular blockade with neostigmine has no effect on the incidence or severity of postoperative nausea and vomiting.
Topics: Adult; Aged; Anesthesia, General; Double-Blind Method; Female; Humans; Hysterectomy; Isoquinolines; | 1997 |
The efficacy of intrathecal neostigmine, intrathecal morphine, and their combination for post-cesarean section analgesia.
Topics: Adult; Analgesics; Analgesics, Opioid; Anesthetics, Local; Bupivacaine; Cesarean Section; Female; Hu | 1998 |
Glycopyrrolate methobromide: 2. comparison with atropine sulphate in anaesthesia.
Topics: Adolescent; Adult; Aged; Atropine; Blood Pressure; Bradycardia; Female; Glycopyrrolate; Humans; Inje | 1975 |
Comparison of the combined effects of atropine and neostigmine with atropine and edrophonium on the lower oesophageal sphincter.
Topics: Adult; Anesthesia, General; Atropine; Edrophonium; Esophagogastric Junction; Female; Gastroesophagea | 1991 |
Influence of neostigmine on postoperative vomiting.
Topics: Aged; Atropine; Hip Prosthesis; Humans; Knee Prosthesis; Nausea; Neostigmine; Postoperative Complica | 1988 |
Neostigmine in postoperative intestinal paralysis. A double-blind, clinical, controlled trial.
Topics: Clinical Trials as Topic; Double-Blind Method; Humans; Intestinal Pseudo-Obstruction; Neostigmine; P | 1988 |
Ceruletide and neostigmine in postoperative intestinal paralysis. A double-blind clinical controlled trial.
Topics: Adolescent; Adult; Aged; Ceruletide; Clinical Trials as Topic; Double-Blind Method; Humans; Intestin | 1986 |
[Therapy of prolonged postoperative intestinal atony following interventions on the aorto-iliac circulation. Results of a prospective randomized study with ceruletide lyophilysate versus neostigmine].
Topics: Aorta, Abdominal; Blood Vessel Prosthesis; Ceruletide; Clinical Trials as Topic; Constipation; Gastr | 1985 |
A clinical study of pancuronium, a new muscular relaxant for abdominal surgery.
Topics: Abdomen; Adolescent; Adult; Age Factors; Aged; Androstanes; Anesthesia; Atropine; Body Weight; Clini | 1972 |
Treatment of paralytic ileus with adrenergic neuronal blocking drugs.
Topics: Clinical Trials as Topic; Guanidines; Humans; Intestinal Obstruction; Neostigmine; Placebos; Postope | 1971 |
Other Studies
120 other studies available for neostigmine and Complication, Postoperative
Article | Year |
---|---|
Association of Sugammadex or Neostigmine With Major Postoperative Pulmonary Complications in Children.
Topics: Adult; Child; Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blockade; Postoperative | 2022 |
Identifying high dose neostigmine as a risk factor for post-operative respiratory complications: a case-control study.
Topics: Acetylcholinesterase; Case-Control Studies; Cholinesterase Inhibitors; Humans; Neostigmine; Neuromus | 2021 |
Sugammadex reversal of muscle relaxant blockade provided less Post-Anesthesia Care Unit adverse effects than neostigmine/glycopyrrolate.
Topics: Anesthesia; Glycopyrrolate; Humans; Iatrogenic Disease; Muscles; Neostigmine; Neuromuscular Blockade | 2022 |
Association between choice of reversal agent for neuromuscular block and postoperative pulmonary complications in patients at increased risk undergoing non-emergency surgery: STIL-STRONGER, a multicentre matched cohort study.
Topics: Cholinesterase Inhibitors; Cohort Studies; Humans; Neostigmine; Neuromuscular Blockade; Neuromuscula | 2023 |
Influence of Sugammadex in Decreasing Postoperative Pulmonary Complications in Thoracic Surgery, is There Evidence?
Topics: Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blockade; Neuromuscular Nondepolarizin | 2022 |
Optimizing Reversal of Neuromuscular Block in Older Adults: Sugammadex or Neostigmine.
Topics: Acetylcholine; Acetylcholinesterase; Aged; Cholinesterase Inhibitors; gamma-Cyclodextrins; Humans; N | 2022 |
Effect of neuromuscular reversal with neostigmine/glycopyrrolate versus sugammadex on postoperative ileus following colorectal surgery.
Topics: Acetylcholinesterase; Adult; Aged; Aged, 80 and over; Analgesics, Opioid; Female; Glycopyrrolate; Hu | 2023 |
How robust are the STRONGER and STIL-STRONGER studies?
Topics: Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blockade; Neuromuscular Blocking Agent | 2023 |
The effects of sugammadex vs. neostigmine on postoperative respiratory complications and advanced healthcare utilisation: a multicentre retrospective cohort study.
Topics: Adult; Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blockade; Patient Acceptance of | 2023 |
Sugammadex and neostigmine: when better may not be best.
Topics: Cholinesterase Inhibitors; Humans; Neostigmine; Neuromuscular Blockade; Postoperative Complications; | 2023 |
Comparison effects of two muscle relaxant strategies on postoperative pulmonary complications in transapical transcatheter aortic valve implantation: a propensity score-matched analysis.
Topics: Adult; Humans; Muscles; Neostigmine; Postoperative Complications; Propensity Score; Rocuronium; Suga | 2023 |
The efficacy and results of medical treatment in postoperative ileus.
Topics: Diatrizoate Meglumine; Humans; Ileus; Intestinal Pseudo-Obstruction; Neostigmine; Postoperative Comp | 2023 |
Usefulness of intra-operative neuromuscular blockade monitoring and reversal agents for postoperative residual neuromuscular blockade: a retrospective observational study.
Topics: Cholinesterase Inhibitors; Delayed Emergence from Anesthesia; Female; Humans; Male; Middle Aged; Neo | 2019 |
Case report series of a novel application of neostigmine to successfully relieve refractory ileus status post-pediatric orthotopic liver transplantation.
Topics: Child; Child, Preschool; Cholinesterase Inhibitors; Humans; Ileus; Infant; Liver Transplantation; Ma | 2019 |
Effects of high neuromuscular blocking agent dose on post-operative respiratory complications in infants and children.
Topics: Child; Child, Preschool; Female; Humans; Infant; Infant, Newborn; Male; Neostigmine; Neuromuscular B | 2020 |
Association of neuromuscular reversal by sugammadex and neostigmine with 90-day mortality after non-cardiac surgery.
Topics: Cholinesterase Inhibitors; Cohort Studies; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neo | 2020 |
Sugammadex versus Neostigmine for Reversal of Neuromuscular Blockade and Postoperative Pulmonary Complications (STRONGER): A Multicenter Matched Cohort Analysis.
Topics: Cholinesterase Inhibitors; Cohort Studies; Female; Humans; Male; Middle Aged; Neostigmine; Neuromusc | 2020 |
Sugammadex and Postoperative Pulmonary Complications: Is Stronger Evidence Required?
Topics: Cohort Studies; gamma-Cyclodextrins; Humans; Neostigmine; Neuromuscular Blockade; Postoperative Comp | 2020 |
Comparison of the effects of sugammadex and neostigmine on hospital stay in robot-assisted laparoscopic prostatectomy: a retrospective study.
Topics: Aged; Cohort Studies; Humans; Laparoscopy; Length of Stay; Male; Middle Aged; Neostigmine; Neuromusc | 2020 |
The "True" Risk of Postoperative Pulmonary Complications and the Socratic Paradox: "I Know that I Know Nothing".
Topics: Humans; Neostigmine; Postoperative Complications; Registries; Retrospective Studies; Sugammadex | 2021 |
The effect of bariatric anaesthesia on postoperative pulmonary functions.
Topics: Adult; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intravenous; Bariatric Surgery; Bl | 2017 |
Incidence of complications in the post-anesthesia care unit and associated healthcare utilization in patients undergoing non-cardiac surgery requiring neuromuscular blockade 2005-2013: A single center study.
Topics: Adult; Airway Extubation; Anesthesia Recovery Period; Cholinesterase Inhibitors; Elective Surgical P | 2017 |
Postoperative pulmonary complications and reversal agents.
Topics: Delayed Emergence from Anesthesia; Humans; Lung; Neostigmine; Postoperative Complications; Sugammade | 2018 |
Implementation of a new strategy to improve the peri-operative management of neuromuscular blockade and its effects on postoperative pulmonary complications.
Topics: Adult; Aged; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Hospital Costs; Hu | 2018 |
Implementation of a new strategy to improve the peri-operative management of neuromuscular blockade and its effects on postoperative pulmonary complications.
Topics: Adult; Aged; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Hospital Costs; Hu | 2018 |
Implementation of a new strategy to improve the peri-operative management of neuromuscular blockade and its effects on postoperative pulmonary complications.
Topics: Adult; Aged; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Hospital Costs; Hu | 2018 |
Implementation of a new strategy to improve the peri-operative management of neuromuscular blockade and its effects on postoperative pulmonary complications.
Topics: Adult; Aged; Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Female; Hospital Costs; Hu | 2018 |
Management of rocuronium neuromuscular block using a protocol for qualitative monitoring and reversal with neostigmine.
Topics: Adult; Aged; Airway Extubation; Clinical Protocols; Cohort Studies; Female; Humans; Incidence; Male; | 2018 |
Evaluation of Neuromuscular Blockade Reversal on Postoperative Mechanical Ventilation Time in a Cardiovascular Surgery Population.
Topics: Aged; Cardiovascular Diseases; Cardiovascular Surgical Procedures; Female; Follow-Up Studies; Humans | 2019 |
Neostigmine reversal doesn't improve postoperative respiratory safety.
Topics: Adult; Aged; Case-Control Studies; Female; Humans; Intraoperative Care; Male; Middle Aged; Neostigmi | 2013 |
Acetylcholinesterase inhibitors reduce neuroinflammation and -degeneration in the cortex and hippocampus of a surgery stress rat model.
Topics: Animals; Anti-Inflammatory Agents; Cerebral Cortex; Cholinesterase Inhibitors; Drug Evaluation, Prec | 2013 |
Reversal of rocuronium induced neuromuscular block with sugammadex or neostigmine: a large observational study.
Topics: Abdomen; Adult; Aged; Airway Extubation; Analgesics, Opioid; Androstanols; Anesthesia Recovery Perio | 2013 |
Reversal of rocuronium induced neuromuscular block with sugammadex or neostigmine: a large observational study.
Topics: Abdomen; Adult; Aged; Airway Extubation; Analgesics, Opioid; Androstanols; Anesthesia Recovery Perio | 2013 |
Reversal of rocuronium induced neuromuscular block with sugammadex or neostigmine: a large observational study.
Topics: Abdomen; Adult; Aged; Airway Extubation; Analgesics, Opioid; Androstanols; Anesthesia Recovery Perio | 2013 |
Reversal of rocuronium induced neuromuscular block with sugammadex or neostigmine: a large observational study.
Topics: Abdomen; Adult; Aged; Airway Extubation; Analgesics, Opioid; Androstanols; Anesthesia Recovery Perio | 2013 |
"Neostigmine-resistant curarization".
Topics: Cholinesterase Inhibitors; Dose-Response Relationship, Drug; Humans; Neostigmine; Neuromuscular Bloc | 2013 |
Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: sugammadex, neostigmine or no reversal.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Female; gamma-Cyclodextrins; Humans; Lung Disease | 2014 |
Postoperative respiratory outcomes in laparoscopic bariatric surgery: comparison of a prospective group of patients whose neuromuscular blockade was reverted with sugammadex and a historical one reverted with neostigmine.
Topics: Adult; Aged; Bariatric Surgery; Cholinesterase Inhibitors; Female; gamma-Cyclodextrins; Humans; Lapa | 2014 |
Neostigmine vs. sugammadex: observational cohort study comparing the quality of recovery using the Postoperative Quality Recovery Scale.
Topics: Adult; Anesthesia Recovery Period; Anesthesia, General; Cholinesterase Inhibitors; Cohort Studies; F | 2014 |
Neostigmine and pulmonary oedema.
Topics: Anesthesia, General; Cholinesterase Inhibitors; Glycopyrrolate; Humans; Infant; Neostigmine; Postope | 2014 |
Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study.
Topics: Adult; Aged; Airway Extubation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 2014 |
Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study.
Topics: Adult; Aged; Airway Extubation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 2014 |
Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study.
Topics: Adult; Aged; Airway Extubation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 2014 |
Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study.
Topics: Adult; Aged; Airway Extubation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 2014 |
Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study.
Topics: Adult; Aged; Airway Extubation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 2014 |
Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study.
Topics: Adult; Aged; Airway Extubation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 2014 |
Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study.
Topics: Adult; Aged; Airway Extubation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 2014 |
Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study.
Topics: Adult; Aged; Airway Extubation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 2014 |
Effects of neostigmine reversal of nondepolarizing neuromuscular blocking agents on postoperative respiratory outcomes: a prospective study.
Topics: Adult; Aged; Airway Extubation; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Aged; | 2014 |
Dose-dependent Association between Intermediate-acting Neuromuscular-blocking Agents and Postoperative Respiratory Complications.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dose-Response | 2015 |
Dose-dependent Association between Intermediate-acting Neuromuscular-blocking Agents and Postoperative Respiratory Complications.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dose-Response | 2015 |
Dose-dependent Association between Intermediate-acting Neuromuscular-blocking Agents and Postoperative Respiratory Complications.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dose-Response | 2015 |
Dose-dependent Association between Intermediate-acting Neuromuscular-blocking Agents and Postoperative Respiratory Complications.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dose-Response | 2015 |
Neostigmine induced anaphylaxis in the wake of surgery.
Topics: Aged; Anaphylaxis; Cholinesterase Inhibitors; Female; Humans; Neostigmine; Postoperative Complicatio | 2015 |
Incidence of postoperative residual neuromuscular blockade after general anesthesia: a prospective, multicenter, anesthetist-blind, observational study.
Topics: Abdomen; Adult; Aged; Anesthesia, General; Delayed Emergence from Anesthesia; Female; Humans; Incide | 2016 |
Neostigmine: You Can't Have It Both Ways.
Topics: Female; Humans; Male; Neostigmine; Neuromuscular Nondepolarizing Agents; Parasympathomimetics; Posto | 2015 |
In Reply.
Topics: Female; Humans; Male; Neostigmine; Neuromuscular Nondepolarizing Agents; Parasympathomimetics; Posto | 2015 |
Neostigmine: Timing and dosing in 2016.
Topics: Anesthesia, General; Cholinesterase Inhibitors; Humans; Neostigmine; Paralysis; Postoperative Compli | 2016 |
Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia.
Topics: Causality; Cholinesterase Inhibitors; Databases, Factual; Female; Humans; Incidence; Male; Middle Ag | 2016 |
Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia.
Topics: Causality; Cholinesterase Inhibitors; Databases, Factual; Female; Humans; Incidence; Male; Middle Ag | 2016 |
Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia.
Topics: Causality; Cholinesterase Inhibitors; Databases, Factual; Female; Humans; Incidence; Male; Middle Ag | 2016 |
Nondepolarizing Neuromuscular Blocking Agents, Reversal, and Risk of Postoperative Pneumonia.
Topics: Causality; Cholinesterase Inhibitors; Databases, Factual; Female; Humans; Incidence; Male; Middle Ag | 2016 |
The O-Sign: early recognition of O-shaped abdominal distension avoids drastic surgical intervention in Ogilvie Syndrome after caesarean section.
Topics: Adult; Cesarean Section; Cholinesterase Inhibitors; Colonic Pseudo-Obstruction; Colonoscopy; Drainag | 2016 |
The Potentially Fatal Ogilvie's Syndrome in Lateral Transpsoas Access Surgery: A Multi-Institutional Experience with 2930 Patients.
Topics: Aged; Aged, 80 and over; Cecum; Cholinesterase Inhibitors; Colonic Pseudo-Obstruction; Female; Human | 2017 |
Intermediate-Acting Nondepolarizing Neuromuscular Blocking Agents and Risk of Postoperative 30-Day Morbidity and Mortality, and Long-term Survival.
Topics: Adult; Aged; Anesthesia Recovery Period; Cholinesterase Inhibitors; Female; Humans; Male; Middle Age | 2017 |
Neostigmine in arthritis; a case with toxic reaction.
Topics: Arthritis; Humans; Neostigmine; Postoperative Complications | 1948 |
[On "Ventricular fibrillation in a patient with type I Brugada syndrome"].
Topics: Brugada Syndrome; Contraindications; Defibrillators; Electric Countershock; Humans; Hypokalemia; Mal | 2008 |
Recurarisation in a surgical ward.
Topics: Acetaminophen; Aged; Analgesics, Non-Narcotic; Anesthesia Recovery Period; Anesthesia, General; Anes | 2008 |
Anesthesia and myotonic dystrophy type 2: a case series.
Topics: Adult; Anesthesia; Anesthetics, Inhalation; Cholinesterase Inhibitors; Female; Humans; Intraoperativ | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
Emergence agitation in adults: risk factors in 2,000 patients.
Topics: Adolescent; Adult; Aged; Analgesics; Anesthesia, General; Anesthetics, Inhalation; Anesthetics, Intr | 2010 |
The effect of neostigmine on postoperative ileus and the healing of colon anastomoses.
Topics: Anastomosis, Surgical; Animals; Body Weight; Cholinesterase Inhibitors; Colon; Dietary Proteins; Fem | 2011 |
Neostigmine and FESS.
Topics: Chronic Disease; Endoscopy; Female; Follow-Up Studies; Humans; Middle Aged; Neostigmine; Otorhinolar | 2011 |
Neostigmine in the treatment of refractory constipation in critically ill children.
Topics: Adolescent; Cathartics; Child; Child, Preschool; Cholinesterase Inhibitors; Constipation; Drug Resis | 2011 |
Re: Neostigmine and Functional Endoscopic Sinus Surgery - ocular side-effects of other general anaesthetic agents.
Topics: Endoscopy; Female; Humans; Neostigmine; Otorhinolaryngologic Surgical Procedures; Parasympathomimeti | 2011 |
[Likely injection of neosynephrine on the place of the prostigmine: an adverse effect!].
Topics: Adult; Anesthesia, General; Blood Gas Analysis; Blood Pressure; Drug Labeling; Drug Packaging; Femal | 2012 |
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema | 2012 |
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema | 2012 |
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema | 2012 |
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema | 2012 |
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema | 2012 |
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema | 2012 |
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema | 2012 |
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema | 2012 |
Intermediate acting non-depolarizing neuromuscular blocking agents and risk of postoperative respiratory complications: prospective propensity score matched cohort study.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Cholinesterase Inhibitors; Fema | 2012 |
A CASE OF SUXAMETHONIUM SENSITIVITY.
Topics: Anesthesia; Anesthesiology; Apnea; Atropine; Bis-Trimethylammonium Compounds; Butyrylcholinesterase; | 1963 |
RESPIRATORY AND CARDIAC ARREST AFTER INTRAVENOUS ADMINISTRATION OF KANAMYCIN WITH REVERSAL OF TOXIC EFFECTS BY NEOSTIGMINE.
Topics: Abscess; Administration, Intravenous; Adolescent; Appendix; Drug Hypersensitivity; Escherichia coli | 1963 |
PROLONGED PARESIS FOLLOWING GALLAMINE; A CASE REPORT.
Topics: Anuria; Apnea; Gallamine Triethiodide; Humans; Kidney; Kidneys, Artificial; Neostigmine; Paralysis; | 1963 |
[OUR EXPERIENCES WITH GENERAL ANESTHESIA IN HEART SURGERY].
Topics: Anesthesia; Anesthesia, General; Cardiac Surgical Procedures; Humans; Neostigmine; Postoperative Com | 1963 |
A CASE OF POST-OPERATIVE APNOEA RESPONDING TO INTRAVENOUS SODIUM BICARBONATE INFUSION.
Topics: Acidosis; Apnea; Atropine; Bicarbonates; Bis-Trimethylammonium Compounds; Gallamine Triethiodide; Hu | 1964 |
[RADIOLOGICAL STUDIES ON THE RESTORATION OF POSTOPERATIVE PARALYTIC ILEUS AND THE EFFECT OF VARIOUS DRUGS AND MANAGEMENT].
Topics: Atropine; Humans; Hypertonic Solutions; Intestinal Obstruction; Intestinal Pseudo-Obstruction; Neost | 1964 |
MANAGEMENT OF THE PATIENT WITH MYASTHENIA GRAVIS FOR THYMECTOMY.
Topics: Anesthesia; Anesthesia, Inhalation; Anesthesiology; Myasthenia Gravis; Neostigmine; Parasympathomime | 1964 |
[A CONTRIBUTION TO THE TREATMENT OF INTESTINAL PARALYSIS IN CHILDHOOD].
Topics: Acidosis; Humans; Hypoxia; Infant; Intestinal Obstruction; Intussusception; Neostigmine; Postoperati | 1964 |
Postoperative delirium and Ogilvie's syndrome resolving with neostigmine.
Topics: Aged; Arthroplasty, Replacement, Knee; Cholinesterase Inhibitors; Colonic Pseudo-Obstruction; Deliri | 2006 |
[Postoperative apnea after suxamethonium].
Topics: Adult; Apnea; Bis-Trimethylammonium Compounds; Blood Transfusion; Cholinesterases; Female; Humans; M | 1966 |
An evoked phonointestinography.
Topics: Electrodiagnosis; Humans; Intestinal Diseases; Laparotomy; Neostigmine; Postoperative Complications | 1967 |
Recurarization with quinine administration after reversal from anaesthesia.
Topics: Atropine; Drug Interactions; Humans; Male; Middle Aged; Neostigmine; Nerve Block; Neuromuscular Junc | 1983 |
[Anesthesia in dystrophia myotonica using the capnogram].
Topics: Adolescent; Adult; Anesthesia; Carbon Dioxide; Female; Heart Function Tests; Humans; Male; Middle Ag | 1984 |
Studies in intestinal healing VI. Effect of pharmacologically induced peristalsis on fresh intestinal anastomoses in dogs.
Topics: Animals; Castor Oil; Colon; Dogs; Gastrointestinal Motility; Ileum; Intestines; Jejunum; Neostigmine | 1980 |
Administration of depolarizing muscle relaxants after non-depolarizer reversal -- when is it safe?
Topics: Aged; Anesthesia; Humans; Male; Neostigmine; Postoperative Complications; Time Factors | 1982 |
Adrenergic and cholinergic contributions to decreased gastric emptying, small intestinal transit, and colonic transit in the postoperative ileus rat.
Topics: Animals; Bethanechol Compounds; Colon; Disease Models, Animal; Gastric Emptying; Gastrointestinal Mo | 1980 |
Does neostigmine cause nausea and vomiting?
Topics: Humans; Nausea; Neostigmine; Postoperative Complications; Vomiting | 1995 |
Neostigmine and postoperative nausea.
Topics: Fasting; Humans; Nausea; Neostigmine; Postoperative Complications | 1994 |
Neostigmine and postoperative nausea.
Topics: Atropine; Humans; Nausea; Neostigmine; Postoperative Complications | 1994 |
Postoperative recurrent paralysis in an infant after mivacurium infusion.
Topics: Female; Humans; Infant; Infusions, Intravenous; Isoquinolines; Mivacurium; Muscle Contraction; Neost | 1994 |
[Thirst is the most common minor complication in the immediate postoperative period].
Topics: Adjuvants, Anesthesia; Adult; Aged; Atropine; Blood Loss, Surgical; Female; Humans; Incidence; Male; | 1996 |
Reversal of neuromuscular blockade.
Topics: Female; Humans; Hysterectomy; Nausea; Neostigmine; Neuromuscular Blockade; Postoperative Complicatio | 1998 |
Other ways to stimulate postoperative bowel function.
Topics: Humans; Intestinal Pseudo-Obstruction; Neostigmine; Postoperative Complications | 1998 |
[Erroneous attitudes in the use of neuromuscular blocking agents].
Topics: Anesthesia Recovery Period; Anesthesiology; Attitude of Health Personnel; Cholinesterase Inhibitors; | 2002 |
[Postoperative ileus. Measurement of the changes in intragastric pressure immediately after abdominal operations (practical deductions)].
Topics: Abdomen; Adrenergic beta-Antagonists; Gastrointestinal Motility; Humans; Intestinal Obstruction; Int | 1975 |
Residual paralysis in the recovery period.
Topics: Humans; Neostigmine; Neuromuscular Blocking Agents; Neuromuscular Junction; Paralysis; Postoperative | 1979 |
[Effect of dihydergot on the postoperative intestinal atonia. Experimental studies].
Topics: Animals; Dihydroergotamine; Female; Intestinal Obstruction; Male; Neostigmine; Postoperative Complic | 1978 |
Glycopyrrolate and cardiac dysrhythmias in geriatric patients after reversal of neuromuscular blockade.
Topics: Aged; Arrhythmias, Cardiac; Atropine; Cardiovascular Diseases; Cholinesterase Inhibitors; Glycopyrro | 1979 |
[Transient and curable myasthenia appearing 3 years after lower right thymectomy].
Topics: Female; Humans; Middle Aged; Myasthenia Gravis; Neostigmine; Postoperative Complications; Pyridostig | 1977 |
Duodenoscopy and endoscopic pancreatography in patients with postive morphine prostigmine tests.
Topics: Adolescent; Adult; Biliary Tract Diseases; Cholangiography; Cholecystectomy; Chronic Disease; Cicatr | 1977 |
[Experimental studies of the effects of gastrin, neostigmine and prostaglandin on the motility of the trunculary vagotomized stomach].
Topics: Animals; Dogs; Gastrins; Gastrointestinal Motility; Neostigmine; Postoperative Complications; Prosta | 1976 |
Tracheobronchial hypersecretion following neostigmine administration.
Topics: Adult; Aged; Bronchi; Female; Humans; Male; Middle Aged; Neostigmine; Postoperative Complications; S | 1975 |
Effects of some drugs on electrical activity of the gut in the postoperative period.
Topics: Cholecystectomy; Cholecystokinin; Gastrointestinal Motility; Humans; Intestinal Obstruction; Jejunum | 1976 |
Renal failure and postoperative respiratory failure: recurarization?
Topics: Adult; Anesthesia, General; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Neostigmine; | 1976 |
Atrial fibrillation associated with neostigmine administration in three cows.
Topics: Animals; Atrial Fibrillation; Cattle; Cattle Diseases; Electrocardiography; Female; Intestinal Obstr | 1990 |
Sensitivity to both vecuronium and neostigmine in a sero-negative myasthenic patient.
Topics: Adult; Apnea; Female; Humans; Myasthenia Gravis; Neostigmine; Postoperative Complications; Vecuroniu | 1989 |
Therapy and clinical progress of cattle with dilatation and torsion of the caecum.
Topics: Animals; Cathartics; Cattle; Cattle Diseases; Cecal Diseases; Cecum; Defecation; Dilatation, Patholo | 1989 |
[Treatment of postoperatory ileus with several drugs].
Topics: Animals; Drug Combinations; Intestinal Obstruction; Mepivacaine; Neostigmine; Phentolamine; Postoper | 1989 |
Recurarisation after vecuronium in a patient with renal failure.
Topics: Acidosis; Adult; Atropine; Female; Humans; Kidney Failure, Chronic; Neostigmine; Neuromuscular Junct | 1987 |
Dehiscence of intestinal anastomoses and anaesthesia.
Topics: Adult; Aged; Anastomosis, Surgical; Anesthesia, General; Colon; Female; Humans; Male; Middle Aged; M | 1988 |
Recurarisation following a suxamethonium-alcuronium sequence in patients with atypical cholinesterase.
Topics: Adult; Alcuronium; Cholinesterases; Female; Humans; Middle Aged; Neostigmine; Postoperative Complica | 1988 |
Prolonged bradycardia and hypotension after neostigmine administration in a patient receiving atenolol.
Topics: Aged; Atenolol; Bradycardia; Drug Interactions; Female; Humans; Hypotension; Neostigmine; Pancuroniu | 1987 |
Colonic anastomotic disruption in myasthenia gravis. Report of two cases.
Topics: Adult; Aged; Anastomosis, Surgical; Colon; Glucagon; Humans; Male; Myasthenia Gravis; Neostigmine; P | 1987 |
Therapeutic rounds: abnormally prolonged responses to neuromuscular blocking agents.
Topics: Apnea; Drug Interactions; Humans; Male; Middle Aged; Neostigmine; Pancuronium; Postoperative Complic | 1986 |
Antagonism of neuromuscular block in the elderly. A comparison of atropine and glycopyrronium in a mixture with neostigmine.
Topics: Age Factors; Aged; Arrhythmias, Cardiac; Atropine; Female; Glycopyrrolate; Heart Rate; Humans; Male; | 1985 |
Pancreas divisum. Detection and management.
Topics: Adult; Cholangiopancreatography, Endoscopic Retrograde; Cholecystectomy; Female; Follow-Up Studies; | 1985 |
Is endoscopic sphincterotomy for disabling biliary-type pain after cholecystectomy effective?
Topics: Anal Canal; Biliary Tract Diseases; Cholangiopancreatography, Endoscopic Retrograde; Cholecystectomy | 1985 |
Letter: Neostigmine after bowel surgery.
Topics: Colon; Drug Antagonism; Humans; Muscle Relaxants, Central; Neostigmine; Postoperative Complications; | 1974 |
Reversal of neuromuscular blockade by artificial diuresis: case report.
Topics: Adjuvants, Anesthesia; Adult; Anesthesia, Inhalation; Atropine; Diuresis; Gallamine Triethiodide; Hu | 1972 |
Prolonged paresis following the administration of gallamine triethiodide (Flaxedil) to a patient with acute pancreatitis.
Topics: Acute Disease; Acute Kidney Injury; Anesthesia, General; Atropine; Gallamine Triethiodide; Humans; M | 1973 |
[Acute respiratory dishess syndrome due to high dosage of penicilline in a case of myasthenia gravis (author's transl)].
Topics: Adult; Apnea; Atropine; Drug Hypersensitivity; Female; Humans; Myasthenia Gravis; Neostigmine; Penic | 1973 |
Efficient anaesthesia with the EMO ether inhaler.
Topics: Adult; Anesthesia, Inhalation; Child; Costs and Cost Analysis; Curare; Ethyl Ethers; Evaluation Stud | 1974 |
Management of resistant ileus by the Neely-Catchpole regimen.
Topics: Aged; Chronic Disease; Depression, Chemical; Drug Resistance; Female; Guanethidine; Humans; Injectio | 1972 |
Thymectomy for myasthenia gravis.
Topics: Activities of Daily Living; Adolescent; Adult; Age Factors; Aged; Bronchopneumonia; Child; Female; F | 1972 |
Ileus and pseudo-obstruction.
Topics: Abdomen; Aged; Female; Gases; Gastrointestinal Motility; Guanethidine; Humans; Intestinal Obstructio | 1971 |
[Experimental and clinical observation of postoperative chronic obstipation].
Topics: Abdomen; Adult; Animals; Chronic Disease; Colon; Constipation; Dogs; Electromyography; Gastrointesti | 1964 |
[Development, prophylaxis and therapy of urinary TRACT infections following gynecological operations].
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents; Electric Stimulation Therapy; Female; Genital Disea | 1967 |
Neostigmine and anastomotic disruption.
Topics: Colectomy; Gastrointestinal Motility; Humans; Intestinal Perforation; Neostigmine; Postoperative Com | 1970 |
Ileus: the restoration of alimentary-tract motility by pharmacological means.
Topics: Aged; Bethanechol Compounds; Female; Gastrointestinal Motility; Guanethidine; Humans; Intestinal Obs | 1971 |
The prevention of muscle pains associated with the use of suxamethonium.
Topics: Adult; Barbiturates; Bronchoscopy; Humans; Injections, Intramuscular; Injections, Intravenous; Male; | 1967 |
Aortic valve replacement in the Wolff-Parkinson-White syndrome.
Topics: Adult; Aortic Valve; Heart Valve Prosthesis; Humans; Male; Neostigmine; Postoperative Complications; | 1968 |
Effect of neostigmine on integrity of ileorectal anastomoses.
Topics: Adolescent; Adult; Aged; Animals; Child; Colectomy; Colitis, Ulcerative; Humans; Ileum; Middle Aged; | 1968 |
[Contribution on the problem of muscle pains after succinylcholine administration].
Topics: Adolescent; Adult; Age Factors; Aged; Anesthesia, General; Child; Female; Germany, East; Halothane; | 1968 |
Neostigmine resistant curarization associated with oliguria of acute onset.
Topics: Acute Kidney Injury; Aged; Anuria; Female; Humans; Male; Middle Aged; Neostigmine; Postoperative Com | 1965 |