neostigmine and Arrhythmia studies

Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.

Research Excerpts

Excerpt	Relevance	Reference
"Cardiac arrhythmias were induced by potassium chloride intravenously as a bolus injection in a dose of 0."	5.26	Effects of atropine, isoprenaline, neostigmine and practocol on cardiac arrhythmias induced by potassium in anesthetized dogs. ( Alitalo, I; Hietala, A, 1977)
" The only existed anticholinergic in Thailand is atropine, which has a more rapid onset than neostigmine resulting in initial tachycardia."	5.19	A comparison of the combination of atropine and glycopyrrolate with atropine alone for the reversal of muscle relaxant. ( Ittichaikulthol, W; Komonhirun, R; Piathong, P; Pisitsak, C; Suyawet, R; Wirachpisit, N, 2014)
"The effect of increased cholinergic activity on reperfusion induced ventricular arrhythmias was studied in alpha chloralose anaesthetised dogs by administering neostigmine during a 25 min occlusion of the anterior left descending coronary artery."	3.67	Role of increased cholinergic activity in reperfusion induced ventricular arrhythmias. ( Abete, P; Bonaduce, D; Canonico, V; Ferrara, N; Leosco, D; Longobardi, G; Rengo, F, 1987)
" It is suggested that the dosage of anticholinergic agents given with neostigmine could be reduced in elderly patients in comparison to that in younger patients."	1.27	Antagonism of neuromuscular block in the elderly. A comparison of atropine and glycopyrronium in a mixture with neostigmine. ( Mirakhur, RK, 1985)
"Edrophonium (0."	1.26	Edrophonium: duration of action and atropine requirement in humans during halothane anesthesia. ( Cronnelly, R; Miller, RD; Morris, RB, 1982)
"Cardiac arrhythmias were induced by potassium chloride intravenously as a bolus injection in a dose of 0."	1.26	Effects of atropine, isoprenaline, neostigmine and practocol on cardiac arrhythmias induced by potassium in anesthetized dogs. ( Alitalo, I; Hietala, A, 1977)
"Supraventricular arrhythmias occurred less frequently in the pyridostigmine groups than in the neostigmine groups."	1.26	Effects on muscarinic receptors of various agents in reversal of neuro-muscular blockade: a study evaluating atropine, glycopyrron, neostigmine and pyridostigmine. ( Eriksen, S; Hansen, EK; Hasselstrøm, L, 1978)

Timeframe	Studies, this research(%)	All Research%
pre-1990	45 (90.00)	18.7374
1990's	2 (4.00)	18.2507
2000's	2 (4.00)	29.6817
2010's	1 (2.00)	24.3611
2020's	0 (0.00)	2.80

Authors	Studies
Ittichaikulthol, W	1
Pisitsak, C	1
Wirachpisit, N	1
Piathong, P	1
Suyawet, R	1
Komonhirun, R	1
Thomas, MC	1
Erstad, BL	1
HAEGER, K	2
JOHANSSON, B	2
SJOSTROM, B	2
YU, KJ	1
HUANG, MH	1
CHIANG, SC	1
LU, CW	1
CHENG, TS	1
LAN, HC	1
FENG, CJ	1
GOTTLIEB, JD	1
SWEET, RB	1
BELLET, S	1
EICHBAUM, FW	1
PEREIRA, CB	1
GREENWOOD, RJ	1
IMMEL, E	1
TILLING, W	1
CUNNINGHAM, GC	1
SCHINITZKER, WF	1
Hayashida, H	1
Miyauchi, Y	1
Vassalle, M	1
Caress, DL	1
Slovin, AJ	1
Stuckey, JH	1
Takkunen, O	1
Salmenperä, M	1
Heinonen, J	1
Cronnelly, R	1
Morris, RB	1
Miller, RD	1
Homola, D	1
Srnova, V	1
Shutt, LE	1
Bowes, JB	1
Alitalo, I	1
Hietala, A	1
Eriksen, S	1
Hansen, EK	1
Hasselstrøm, L	1
Muravchick, S	1
Owens, WD	1
Felts, JA	1
Gyermek, L	1
Raymond, CW	1
Wetterslev, J	1
Jarnvig, I	1
Jørgensen, LN	1
Olsen, NV	1
Spiers, SP	1
Yungbluth, J	1
Henry, JD	1
McAnallen, K	1
Albee, DT	1
Ferrara, N	2
Bonaduce, D	2
Abete, P	2
Leosco, D	2
Caccese, P	1
Tuccillo, B	1
Longobardi, G	2
Canonico, V	2
Rengo, F	2
Mirakhur, RK	1
Berry, FA	1
Lake, CL	1
Johns, RA	1
Rogers, BM	1
Schamroth, L	1
Robinson, SJ	1
Lees, P	1
Tavernor, WD	1
Schoenberg, AA	1
Mennicken, U	1
Simon, R	1
Brambring, P	1
Heintzen, PH	1
James, TN	1
Kanarek, KS	1
Thomson, PD	1
Levin, SE	1
List, WF	1
Baraka, A	2
Marriott, HJ	1
Smith, M	1
Ray, CT	1
Rossier, AB	2
Ziegler, WH	2
Duchosal, PW	2
Meylan, J	2
Rosner, V	1
Kepes, ER	1
Foldes, FF	1
Huidobro, F	1
Lewin, J	1
Huidobro, JP	1
Garbarino, JA	1
Samaniego, E	1
Ghoneim, MM	1
Kjellberg, M	1
Tammisto, T	1
Salem, MR	1
Ylagan, LB	1
Angel, JJ	1
Vedam, VS	1
Collins, VJ	1
Gil'mar, IS	1
Mei, V	1
Sardella, F	1
Valora, N	1
Fekete, M	1
Pevzner, GI	1

Trial			Phase	Enrollment	Study Type	Start Date	Status
A Prospective, Randomized Trial of Enteral Naloxone Versus a Traditional Bowel Regimen in Prevention of Constipation and Decreased Gastric Motility in Critically Ill Trauma Patients[NCT00799201]			Phase 4	3 participants (Actual)	Interventional	2007-08-31	Terminated (stopped due to Naloxone became unavailable due to manufacturing shortatges requiring the study to be terminated.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Article	Year
CHEMICAL THERAPY OF CARDIAC ARRHYTHMIAS. Biochemical clinics, 1963, Volume: 2 Topics: Acetylcholine; Arrhythmias, Cardiac; Atropine; Digitalis; Digitalis Glycosides; Ephedrine; Epinephri	1963
Atropine and hyoscine. Anaesthesia, 1979, Volume: 34, Issue:5 Topics: Arrhythmias, Cardiac; Atropine; Cardiac Output; Central Nervous System; Chemical Phenomena; Chemistr	1979
The diagnosis, significance, and management of A-V nodal rhythms. Cardiovascular clinics, 1970, Volume: 2, Issue:2 Topics: Action Potentials; Anti-Arrhythmia Agents; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atropine; Cardia	1970
Treatment of cardiac arrhythmias. Pediatric clinics of North America, 1964, Volume: 11, Issue:2 Topics: Adams-Stokes Syndrome; Arrhythmia, Sinus; Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter;	1964
[Cardiac arrhythmias during anesthesia: their origin and pharmacological control]. Der Anaesthesist, 1966, Volume: 15, Issue:11 Topics: Anesthetics; Arrhythmias, Cardiac; Catecholamines; Digitalis Glycosides; Electroshock; Heart Disease	1966
Management of cardiac dysrhythmias complicating acute myocardial infarction. Geriatrics, 1968, Volume: 23, Issue:9 Topics: Arrhythmias, Cardiac; Atrial Fibrillation; Atrial Flutter; Atropine; Bradycardia; Bretylium Compound	1968

Article	Year
A comparison of the combination of atropine and glycopyrrolate with atropine alone for the reversal of muscle relaxant. Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2014, Volume: 97, Issue:7 Topics: Adult; Anesthesia, General; Arrhythmias, Cardiac; Atropine; Cholinesterase Inhibitors; Glycopyrrolat	2014
Safety of enteral naloxone and i.v. neostigmine when used to relieve constipation. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2003, Jun-15, Volume: 60, Issue:12 Topics: Administration, Oral; Administration, Rectal; Adolescent; Adult; Aged; Arrhythmias, Cardiac; Colic;	2003
Split-dose atropine versus glycopyrrolate with neostigmine for reversal of gallamine-induced neuromuscular blockade. Acta anaesthesiologica Scandinavica, 1991, Volume: 35, Issue:5 Topics: Adult; Arrhythmias, Cardiac; Atropine; Female; Gallamine Triethiodide; Glycopyrrolate; Heart Rate; H	1991
Recovery characteristics following antagonism of vecuronium with edrophonium, neostigmine or pyridostigmine. AANA journal, 1988, Volume: 56, Issue:2 Topics: Adult; Aged; Arrhythmias, Cardiac; Blood Pressure; Cholinesterase Inhibitors; Clinical Trials as Top	1988

neostigmine and Arrhythmia

Research Excerpts

Research

Studies (50)

Authors

Clinical Trials (1)

Trial Overview

Reviews

Trials

Other Studies

Article	Year
Electrocardiographic studies on fibrillating and nonfibrillating hypothermic dogs with or without previous treatment with acetylcholine or procaine amide. American heart journal, 1957, Volume: 53, Issue:1 Topics: Acetylcholine; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; D	1957
Electrocardiographic studies on fibrillating and nonfibrillating hypothermic dogs with or without previous treatment with acetylcholine or procaine amide. American heart journal, 1957, Volume: 53, Issue:1 Topics: Acetylcholine; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; D	1957
Electrocardiographic studies on fibrillating and nonfibrillating hypothermic dogs with or without previous treatment with acetylcholine or procaine amide. American heart journal, 1957, Volume: 53, Issue:1 Topics: Acetylcholine; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; D	1957
Electrocardiographic studies on fibrillating and nonfibrillating hypothermic dogs with or without previous treatment with acetylcholine or procaine amide. American heart journal, 1957, Volume: 53, Issue:1 Topics: Acetylcholine; Animals; Arrhythmias, Cardiac; Brugada Syndrome; Cardiac Conduction System Disease; D	1957
Arrhythmias and their management during mitral commissurotomy; with special reference to persistent ventricular flutter. Chinese medical journal (Peking, China : 1932), 1957, Volume: 75, Issue:7 Topics: Arrhythmias, Cardiac; Cardiac Surgical Procedures; Digitalis; Digitalis Glycosides; Mitral Valve Ste	1957
The antagonism of curare: the cardiac effects of atropine and neostigmine. Canadian Anaesthetists' Society journal, 1963, Volume: 10 Topics: Arrhythmias, Cardiac; Atropine; Bradycardia; Curare; Heart; Humans; Neostigmine	1963
EFFECT OF CRANIAL TRAUMA ON THE ELECTROCARDIOGRAM EXPERIMENTS IN GUINEA-PIGS. Cardiologia, 1964, Volume: 44 Topics: Arrhythmias, Cardiac; Atropine; Brain Injuries; Craniocerebral Trauma; Electrocardiography; Ergotami	1964
THE PROPER USE OF CAROTID SINUS STIMULATION. Journal of the American Geriatrics Society, 1964, Volume: 12 Topics: Angina Pectoris; Arrhythmias, Cardiac; Carotid Sinus; Diagnosis; Digitalis Glycosides; Drug Therapy;	1964
[ON THE CLINICAL ASPECTS OF BOTULISM]. Arztliche Forschung, 1965, Jan-10, Volume: 19 Topics: Acetylcholine; Arrhythmias, Cardiac; Botulism; Drug Therapy; Eye Manifestations; Humans; Muscular Di	1965
Use of neo-synephrine in paroxysmal supraventricular tachycardia. The Journal of pediatrics, 1950, Volume: 37, Issue:5 Topics: Arrhythmias, Cardiac; Neostigmine; Phenylephrine; Tachycardia, Supraventricular	1950
Anaesthetic management in patients with high-risk Brugada syndrome. British journal of anaesthesia, 2006, Volume: 97, Issue:1 Topics: Anesthesia, General; Arrhythmias, Cardiac; Cholinesterase Inhibitors; Drug Administration Schedule;	2006
On the cause of ventricular asystole during vagal stimulation. Circulation research, 1967, Volume: 20, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Dogs; Electric Stimulation; Heart; Heart Conduction System; Neostigmi	1967
Atropine vs glycopyrrolate during reversal of pancuronium block in patients anaesthetized with halothane. Acta anaesthesiologica Scandinavica, 1984, Volume: 28, Issue:4 Topics: Adult; Anesthesia, General; Arrhythmias, Cardiac; Atropine; Blood Pressure; Electrocardiography; Fem	1984
Edrophonium: duration of action and atropine requirement in humans during halothane anesthesia. Anesthesiology, 1982, Volume: 57, Issue:4 Topics: Anesthesia, General; Arrhythmias, Cardiac; Atropine; Blood Pressure; Dose-Response Relationship, Dru	1982
Anomalous atrio-ventricular connections and their features. Advances in cardiology, 1976, Volume: 16 Topics: Acetylcholine; Adrenergic beta-Antagonists; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Atrioventr	1976
Effects of atropine, isoprenaline, neostigmine and practocol on cardiac arrhythmias induced by potassium in anesthetized dogs. Nordisk veterinaermedicin, 1977, Volume: 29, Issue:11 Topics: Animals; Arrhythmias, Cardiac; Atropine; Autonomic Agents; Dogs; Female; Heart Rate; Homeostasis; Is	1977
Effects on muscarinic receptors of various agents in reversal of neuro-muscular blockade: a study evaluating atropine, glycopyrron, neostigmine and pyridostigmine. Acta anaesthesiologica Scandinavica, 1978, Volume: 22, Issue:4 Topics: Adolescent; Adult; Arrhythmias, Cardiac; Atropine; Glycopyrrolate; Heart Rate; Humans; Middle Aged;	1978
Glycopyrrolate and cardiac dysrhythmias in geriatric patients after reversal of neuromuscular blockade. Canadian Anaesthetists' Society journal, 1979, Volume: 26, Issue:1 Topics: Aged; Arrhythmias, Cardiac; Atropine; Cardiovascular Diseases; Cholinesterase Inhibitors; Glycopyrro	1979
Clinical pharmacology of the reversal of neuromuscular block. International journal of clinical pharmacology and biopharmacy, 1977, Volume: 15, Issue:8 Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Atropine; Child; Child, Preschool; Edrophonium; Femal	1977
Letter: Neostigmine methysulfate in the treatment of cardiac arryhthmia induced by perphenazine-amitriptyline. Canadian Medical Association journal, 1976, Jan-24, Volume: 114, Issue:2 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Child, Preschool; Drug Combin	1976
Atropine or glycopyrronium?--a dangerous dilemma. Anaesthesia, 1991, Volume: 46, Issue:2 Topics: Aged; Arrhythmias, Cardiac; Atropine; Female; Glycopyrrolate; Humans; Neostigmine; Neuromuscular Jun	1991
[Role of the increased cholinergic activity in prevention of reperfusion-induced arrhythmia in dog experiments]. Cardiologia (Rome, Italy), 1987, Volume: 32, Issue:4 Topics: Animals; Arrhythmias, Cardiac; Coronary Disease; Dogs; Female; Heart Rate; Male; Neostigmine; Parasy	1987
Role of increased cholinergic activity in reperfusion induced ventricular arrhythmias. Cardiovascular research, 1987, Volume: 21, Issue:4 Topics: Animals; Arrhythmias, Cardiac; Atropine; Coronary Circulation; Dogs; Female; Heart Rate; Heart Ventr	1987
Antagonism of neuromuscular block in the elderly. A comparison of atropine and glycopyrronium in a mixture with neostigmine. Anaesthesia, 1985, Volume: 40, Issue:3 Topics: Age Factors; Aged; Arrhythmias, Cardiac; Atropine; Female; Glycopyrrolate; Heart Rate; Humans; Male;	1985
Mitral valve prolapse--another cause of intraoperative dysrhythmias in the pediatric patient. Anesthesiology, 1985, Volume: 62, Issue:5 Topics: Adolescent; Arrhythmias, Cardiac; Atropine; Enflurane; Funnel Chest; Halothane; Humans; Intraoperati	1985
An investigation of the actions of the neuromuscular blocking agent, dipyrandium iodide, on cardiovascular and respiratory function in the horse. Research in veterinary science, 1969, Volume: 10, Issue:5 Topics: Androstanes; Anesthesia, Inhalation; Animals; Apnea; Arrhythmias, Cardiac; Blood Circulation; Blood	1969
Stroke volume estimation from aortic pressure with correction for arrhythmias. European journal of cardiology, 1974, Volume: 2, Issue:1 Topics: Animals; Aorta; Arrhythmias, Cardiac; Arterial Occlusive Diseases; Blood Pressure; Cardiac Output; C	1974
Sicknesses of the sinus node. The Western journal of medicine, 1974, Volume: 121, Issue:6 Topics: Animals; Arrhythmias, Cardiac; Atrioventricular Node; Depression, Chemical; Dogs; Exercise Test; Hea	1974
The management of imipramine (Tofranil) intoxication in children. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1973, May-19, Volume: 47, Issue:19 Topics: Adult; Anticonvulsants; Arrhythmias, Cardiac; Electrocardiography; Emergencies; Female; Gastric Lava	1973
Safe reversal. 1. Atropine followed by neostigmine. An electrocardiographic study. British journal of anaesthesia, 1968, Volume: 40, Issue:1 Topics: Adjuvants, Anesthesia; Adult; Arrhythmias, Cardiac; Atropine; Heart; Heart Rate; Humans; Hypotension	1968
Cardiac arrhythmias, increased intracranial pressure, and the autonomic nervous system. Chest, 1972, Volume: 61, Issue:2 Topics: Animals; Arrhythmias, Cardiac; Atropine; Autonomic Nervous System; Blood Pressure; Dogs; Electrocard	1972
Sexual function and dysreflexia. Paraplegia, 1971, Volume: 9, Issue:1 Topics: Accidents, Traffic; Adult; Arrhythmias, Cardiac; Blood Pressure; Catecholamines; Dysautonomia, Famil	1971
The effects of atropine and neostigmine on heart rate and rhythm. Recommendation for their use to reverse residual neuromuscular block. British journal of anaesthesia, 1971, Volume: 43, Issue:11 Topics: Adult; Aged; Anesthesia, General; Arrhythmias, Cardiac; Atropine; Benperidol; Female; Fentanyl; Halo	1971
[Sexual function, autonomic dysreflexia and catecholamines in traumatic medullary lesions]. Schweizerische medizinische Wochenschrift, 1971, May-29, Volume: 101, Issue:21 Topics: Adult; Arrhythmias, Cardiac; Blood Pressure Determination; Catecholamines; Dysautonomia, Familial; E	1971
Quinine-like actions of two 2-amino-2-phenol alkyl derivatives. Archives internationales de pharmacodynamie et de therapie, 1969, Volume: 182, Issue:1 Topics: Acetylcholine; Animals; Arrhythmias, Cardiac; Blood Pressure; Butyrates; Carotid Arteries; Cats; Che	1969
[Magnesium-ion physiology]. Anesthesiology, 1970, Volume: 33, Issue:3 Topics: Adjuvants, Anesthesia; Arrhythmias, Cardiac; Atropine; Calcium; Humans; Magnesium; Neostigmine	1970
Heart-rate changes after atropine and neostigmine given for the reversion of muscle paralysis. Acta anaesthesiologica Scandinavica, 1970, Volume: 14, Issue:3 Topics: Adult; Arrhythmias, Cardiac; Atropine; Heart Rate; Humans; Middle Aged; Neostigmine; Paralysis; Tubo	1970
Reversal of curarization with atropine-neostigmine mixture in patients with congenital cardiac disease. British journal of anaesthesia, 1970, Volume: 42, Issue:11 Topics: Adolescent; Arrhythmias, Cardiac; Atropine; Child; Child, Preschool; Cyanosis; Electrocardiography;	1970
Safe reversal. 2. Atropine-neostigmine mixture: an electrocardiographic study. British journal of anaesthesia, 1968, Volume: 40, Issue:1 Topics: Adjuvants, Anesthesia; Adolescent; Adult; Arrhythmias, Cardiac; Atropine; Carbon Dioxide; Electrocar	1968
[Controlling attacks of paroxysmal tachycardia and fibrillation arrhythmia]. Vrachebnoe delo, 1968, Volume: 3 Topics: Arrhythmias, Cardiac; Glucose; Humans; Neostigmine; Procainamide; Quinine; Strophanthins	1968
[Action some drugs on the electrocardiogram of the rat. XII. Prostigmine]. Bollettino della Societa italiana di biologia sperimentale, 1965, Mar-31, Volume: 41, Issue:6 Topics: Animals; Arrhythmias, Cardiac; Electrocardiography; Heart; Neostigmine; Rats	1965
A possible role of cholinergic effects in the noradrenaline potentiating action of imipramine. Medicina et pharmacologia experimentalis. International journal of experimental medicine, 1966, Volume: 14, Issue:3 Topics: Animals; Arrhythmias, Cardiac; Bradycardia; Cats; Dogs; Electrocardiography; Female; Hexamethonium C	1966
[On a rare form of disorder of heart rhythm in proserine therapy]. Klinicheskaia meditsina, 1966, Volume: 44, Issue:8 Topics: Adult; Arrhythmias, Cardiac; Female; Humans; Neostigmine	1966