neostigmine has been researched along with Amyotrophic Lateral Sclerosis in 7 studies
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Seven patients with amyotrophic lateral sclerosis participated in a double-blind cross-over trial of oral physostigmine and neostigmine (10 and 45 mg/day, respectively, for 3 days)." | 9.06 | Cholinesterase inhibitors lack therapeutic effect in amyotrophic lateral sclerosis. A controlled study of physostigmine versus neostigmine. ( Aquilonius, SM; Askmark, H; Eckernäs, SA; Gillberg, PG; Hilton-Brown, P; Rydin, E; Stålberg, E, 1986) |
| "Constipation is a common complication of amyotrophic lateral sclerosis (ALS), especially as the disease progresses." | 5.33 | Neostigmine: an alternative treatment for constipation. ( Fu, A, 2005) |
| "Seven patients with amyotrophic lateral sclerosis participated in a double-blind cross-over trial of oral physostigmine and neostigmine (10 and 45 mg/day, respectively, for 3 days)." | 5.06 | Cholinesterase inhibitors lack therapeutic effect in amyotrophic lateral sclerosis. A controlled study of physostigmine versus neostigmine. ( Aquilonius, SM; Askmark, H; Eckernäs, SA; Gillberg, PG; Hilton-Brown, P; Rydin, E; Stålberg, E, 1986) |
| "Constipation is a common complication of amyotrophic lateral sclerosis (ALS), especially as the disease progresses." | 1.33 | Neostigmine: an alternative treatment for constipation. ( Fu, A, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 1 (14.29) | 24.3611 |
| 2020's | 1 (14.29) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, G | 1 |
| Hrabe, J | 1 |
| Sanchez, R | 1 |
| Gotkine, M | 1 |
| Marc, G | 1 |
| Rozenstein, L | 1 |
| Leah, R | 1 |
| Einstein, O | 1 |
| Ofira, E | 1 |
| Abramsky, O | 1 |
| Oded, A | 1 |
| Argov, Z | 1 |
| Zohar, A | 1 |
| Rosenmann, H | 1 |
| Hanna, R | 1 |
| Fu, A | 1 |
| Araki, S | 1 |
| Shibasaki, H | 1 |
| Zaleska, B | 1 |
| Aquilonius, SM | 1 |
| Askmark, H | 1 |
| Eckernäs, SA | 1 |
| Gillberg, PG | 1 |
| Hilton-Brown, P | 1 |
| Rydin, E | 1 |
| Stålberg, E | 1 |
| Stern, FH | 1 |
1 review available for neostigmine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
[Progress in the treatment of degenerative diseases of the nervous system. Selected problems].
Topics: Amyotrophic Lateral Sclerosis; Antiparkinson Agents; Humans; Huntington Disease; Lithium; Neostigmin | 1980 |
1 trial available for neostigmine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Cholinesterase inhibitors lack therapeutic effect in amyotrophic lateral sclerosis. A controlled study of physostigmine versus neostigmine.
Topics: Adult; Aged; Amyotrophic Lateral Sclerosis; Clinical Trials as Topic; Evoked Potentials; Female; Hum | 1986 |
5 other studies available for neostigmine and Amyotrophic Lateral Sclerosis
| Article | Year |
|---|---|
Colostomy as a definitive treatment in an ALS patient with acute colonic Pseudo-obstruction refractory to medical management, a case report.
Topics: Acute Disease; Adult; Amyotrophic Lateral Sclerosis; Colonic Pseudo-Obstruction; Colostomy; Dioctyl | 2022 |
Presymptomatic treatment with acetylcholinesterase antisense oligonucleotides prolongs survival in ALS (G93A-SOD1) mice.
Topics: Acetylcholinesterase; Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Disease Progre | 2013 |
Neostigmine: an alternative treatment for constipation.
Topics: Aged; Amyotrophic Lateral Sclerosis; Colonic Pseudo-Obstruction; Constipation; Critical Illness; Fem | 2005 |
[Variations in serum amylase responding to the neostigmine test in amyotrophic lateral sclerosis].
Topics: Adult; Amylases; Amyotrophic Lateral Sclerosis; Glucose Tolerance Test; Humans; Iodine Radioisotopes | 1966 |
Myasthenia gravis, an often overlooked disease in the geriatric group.
Topics: Adrenal Insufficiency; Aged; Amyotrophic Lateral Sclerosis; Chronic Disease; Curare; Diagnosis, Diff | 1966 |