neostigmine has been researched along with Aging in 15 studies
Neostigmine: A cholinesterase inhibitor used in the treatment of myasthenia gravis and to reverse the effects of muscle relaxants such as gallamine and tubocurarine. Neostigmine, unlike PHYSOSTIGMINE, does not cross the blood-brain barrier.
neostigmine : A quaternary ammonium ion comprising an anilinium ion core having three methyl substituents on the aniline nitrogen, and a 3-[(dimethylcarbamoyl)oxy] substituent at position 3. It is a parasympathomimetic which acts as a reversible acetylcholinesterase inhibitor.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The incidence of postoperative nausea and vomiting (PONV) in PACU was higher in neostigmine-reversed than sugammadex-reversed patients (21." | 5.40 | Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: sugammadex, neostigmine or no reversal. ( De Mel, A; Falke, L; Gillies, E; Greenaway, M; Johnston, F; Ledowski, T; Phillips, M; Tiong, WS, 2014) |
| "neostigmine was administered." | 5.31 | Assessment of predictors of response to neostigmine for acute colonic pseudo-obstruction. ( Baron, TH; Harewood, GC; Loftus, CG, 2002) |
| "Neostigmine has a similar, although longer, effect." | 2.69 | Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium. ( Brown, R; Fisher, DM; Fogarty, D; Kirkegaard-Nielsen, H; Sharma, ML; Szenohradszky, J, 2000) |
| "We have studied the dose-response relationship for neostigmine in 36 adult (ages 18-50 yr) and 36 elderly (ages > 70 yr) subjects during antagonism of neuromuscular block induced by vecuronium." | 2.67 | Dose-response relationships for neostigmine antagonism of vecuronium-induced neuromuscular block in adults and the elderly. ( Cooper, R; McCarthy, GJ; Mirakhur, RK; Stanley, JC, 1992) |
| "In 2-month-old mice, no β-amyloid plaques deposition, but the presence of soluble oligomers, were found in CA1 area but not in dentate gyrus (DG)." | 1.42 | Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease. ( Borsello, T; Calabresi, P; Costa, C; de Iure, A; Di Filippo, M; Ghiglieri, V; Sclip, A; Tantucci, M; Tozzi, A, 2015) |
| "The incidence of postoperative nausea and vomiting (PONV) in PACU was higher in neostigmine-reversed than sugammadex-reversed patients (21." | 1.40 | Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: sugammadex, neostigmine or no reversal. ( De Mel, A; Falke, L; Gillies, E; Greenaway, M; Johnston, F; Ledowski, T; Phillips, M; Tiong, WS, 2014) |
| "neostigmine was administered." | 1.31 | Assessment of predictors of response to neostigmine for acute colonic pseudo-obstruction. ( Baron, TH; Harewood, GC; Loftus, CG, 2002) |
| "Metocurine 0." | 1.27 | Duration of action of neostigmine and pyridostigmine in the elderly. ( Matteo, RS; Ornstein, E; Young, WL, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (20.00) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 2 (13.33) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| He, N | 1 |
| Yu, L | 1 |
| Xu, M | 1 |
| Huang, Y | 1 |
| Wang, X | 1 |
| Chen, L | 1 |
| Yue, S | 1 |
| Ledowski, T | 1 |
| Falke, L | 1 |
| Johnston, F | 1 |
| Gillies, E | 1 |
| Greenaway, M | 1 |
| De Mel, A | 1 |
| Tiong, WS | 1 |
| Phillips, M | 1 |
| Tozzi, A | 1 |
| Sclip, A | 1 |
| Tantucci, M | 1 |
| de Iure, A | 1 |
| Ghiglieri, V | 1 |
| Costa, C | 1 |
| Di Filippo, M | 1 |
| Borsello, T | 1 |
| Calabresi, P | 1 |
| El-Moursy, SA | 1 |
| Shawky, HM | 1 |
| Abdel Wahab, Z | 1 |
| Rashed, L | 1 |
| Loftus, CG | 1 |
| Harewood, GC | 1 |
| Baron, TH | 1 |
| Karanth, S | 1 |
| Liu, J | 1 |
| Ray, A | 1 |
| Pope, C | 1 |
| Erdelyi, L | 1 |
| Krenz, WD | 1 |
| Nielsen, HK | 1 |
| May, O | 1 |
| Szenohradszky, J | 1 |
| Fogarty, D | 1 |
| Kirkegaard-Nielsen, H | 1 |
| Brown, R | 1 |
| Sharma, ML | 1 |
| Fisher, DM | 1 |
| Umegaki, H | 1 |
| Tamaya, N | 1 |
| Shinkai, T | 1 |
| Iguchi, A | 1 |
| Okamoto, M | 1 |
| Walewski, JL | 1 |
| Artusio, JF | 1 |
| Riker, WF | 1 |
| McCarthy, GJ | 1 |
| Cooper, R | 1 |
| Stanley, JC | 1 |
| Mirakhur, RK | 1 |
| Koscielniak-Nielsen, ZJ | 1 |
| Law-Min, JC | 1 |
| Donati, F | 1 |
| Bevan, DR | 1 |
| Clement, P | 1 |
| Wise, R | 1 |
| Debaene, B | 1 |
| Meistelman, C | 1 |
| d'Hollander, A | 1 |
| Young, WL | 1 |
| Matteo, RS | 1 |
| Ornstein, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Can we Antagonize Mivacurium With Neostigmine[NCT03019835] | 80 participants (Actual) | Interventional | 2016-12-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for neostigmine and Aging
| Article | Year |
|---|---|
[The optimal administration time for neostigmine following atracurium blockade. Kinetics of antagonists].
Topics: Adult; Aging; Anesthesia; Atracurium; Body Weight; Electric Stimulation; Female; Humans; Neostigmine | 1994 |
Effect of edrophonium and neostigmine on the pharmacokinetics and neuromuscular effects of mivacurium.
Topics: Adult; Aged; Aging; Cholinesterase Inhibitors; Drug Interactions; Edrophonium; Female; Humans; Isoqu | 2000 |
Dose-response relationships for neostigmine antagonism of vecuronium-induced neuromuscular block in adults and the elderly.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Dose-Response Relationship, Drug; Humans; Middle | 1992 |
Dose-response relations of doxacurium and its reversal with neostigmine in young adults and healthy elderly patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Dose-Response Relationship, Drug; Drug Interactio | 1992 |
11 other studies available for neostigmine and Aging
| Article | Year |
|---|---|
Near-infrared fluorescent probe for evaluating the acetylcholinesterase effect in the aging process and dietary restriction via fluorescence imaging.
Topics: Acetylcholinesterase; Aging; Animals; Brain; Cholinesterase Inhibitors; Diet Therapy; Female; Fluore | 2021 |
Retrospective investigation of postoperative outcome after reversal of residual neuromuscular blockade: sugammadex, neostigmine or no reversal.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Aging; Female; gamma-Cyclodextrins; Humans; Lung Disease | 2014 |
Region- and age-dependent reductions of hippocampal long-term potentiation and NMDA to AMPA ratio in a genetic model of Alzheimer's disease.
Topics: Aging; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Alzheimer Disease; Amyloid beta-Pro | 2015 |
The effect of memantine and levodopa/carbidopa on the responses of phrenic nerve-diaphragm preparations from aged rats.
Topics: Aging; Animals; Carbidopa; Diaphragm; Electric Stimulation; Gallamine Triethiodide; Gene Expression | 2009 |
Assessment of predictors of response to neostigmine for acute colonic pseudo-obstruction.
Topics: Acute Disease; Aged; Aging; Cholinesterase Inhibitors; Colonic Pseudo-Obstruction; Female; Forecasti | 2002 |
Comparative in vivo effects of parathion on striatal acetylcholine accumulation in adult and aged rats.
Topics: Acetylcholine; Aging; Animals; Binding, Competitive; Cholinesterase Inhibitors; Corpus Striatum; Def | 2007 |
Electrophysiological aspects of synaptic transmission at the electromotor junction of Torpedo marmorata.
Topics: Aging; Animals; Calcium; Electric Organ; Evoked Potentials; Female; Magnesium; Male; Motor Neurons; | 1984 |
The metabolism of plasma glucose and catecholamines in Alzheimer's disease.
Topics: Acetylcholine; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Animals; Blood Glucose; Catecholam | 2000 |
Neuromuscular pharmacology in rat neonates: development of responsiveness to prototypic blocking and reversal drugs.
Topics: 4-Aminopyridine; Aging; Animals; Animals, Newborn; Cholinesterase Inhibitors; Curare; Dose-Response | 1992 |
Recovery from vecuronium neuromuscular blockade following neostigmine administration in infants, children, and adults during halothane anesthesia.
Topics: Adult; Aged; Aging; Anesthesia, Inhalation; Child; Child, Preschool; Halothane; Humans; Infant; Midd | 1989 |
Duration of action of neostigmine and pyridostigmine in the elderly.
Topics: Adult; Aged; Aging; Humans; Injections, Intravenous; Neostigmine; Pyridostigmine Bromide; Time Facto | 1988 |