nelumal-a and Lung-Neoplasms

nelumal-a has been researched along with Lung-Neoplasms* in 1 studies

Other Studies

1 other study(ies) available for nelumal-a and Lung-Neoplasms

Article	Year
Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia. Journal of natural products, 2002, Volume: 65, Issue:6 Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines. Topics: Alcohols; Antineoplastic Agents, Phytogenic; Asteraceae; Catalysis; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Inhibitory Concentration 50; KB Cells; Lung Neoplasms; Medicine, Chinese Traditional; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Tumor Cells, Cultured	2002

Article

Year

Syntheses of two cytotoxic sinapyl alcohol derivatives and isolation of four new related compounds from Ligularia nelumbifolia.

Journal of natural products, 2002, Volume: 65, Issue:6

Phytochemical reinvestigation on Ligularia nelumbifolia afforded four novel sinapyl alcohol analogues named nelumols B-E (1-4) and three known sinapyl alcohol derivatives (5-7). Their structures were elucidated by NMR techniques. Total syntheses of cytotoxic geranyloxy sinapyl alcohol (6) and geranyloxy sinapyl aldehyde (7) were carried out via two different paths. The 4-O-benzyl-substituted analogues (20 and 27) as well as the 4-O-(2-methylbutenyl) derivatives (34 and 35) were also synthesized. The cytotoxicities of 6 and 7 were measured using A-549, HL-60, and KB cancer cell lines.

Topics: Alcohols; Antineoplastic Agents, Phytogenic; Asteraceae; Catalysis; Drug Screening Assays, Antitumor; HL-60 Cells; Humans; Inhibitory Concentration 50; KB Cells; Lung Neoplasms; Medicine, Chinese Traditional; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Plants, Medicinal; Tumor Cells, Cultured

2002