Page last updated: 2024-08-24

nelfinavir and Thyroid Neoplasms

nelfinavir has been researched along with Thyroid Neoplasms in 2 studies

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Boyle, L; Burman, K; Costello, J; Jensen, K; Klubo-Gwiezdzinska, J; Kushchayeva, Y; Patel, A; Recupero, A; Vasko, V	1
Burns-Naas, LA; Capen, CC; Chen, M; Cook, JC; Evering, W; Furman, G; Gasser, R; Ivett, JL; Jessen, B; McClain, RM; Ryan, TE; Shetty, B; Stevens, G; Theiss, JC; Webber, S; Wu, E; Zorbas, M	1

Other Studies

2 other study(ies) available for nelfinavir and Thyroid Neoplasms

Article	Year
The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells. The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:5 Topics: Adult; Aged; Apoptosis; Autophagy; Carcinoma, Medullary; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Endoplasmic Reticulum Stress; Female; HIV Protease Inhibitors; HSP90 Heat-Shock Proteins; Humans; Male; Middle Aged; Mutation; Nelfinavir; Oxidative Stress; Proto-Oncogene Proteins c-ret; Signal Transduction; Thyroid Neoplasms	2014
Increase in thyroid follicular cell tumors in nelfinavir-treated rats observed in a 2-year carcinogenicity study is consistent with a rat-specific mechanism of thyroid neoplasia. Human & experimental toxicology, 2005, Volume: 24, Issue:12 Topics: Adenocarcinoma, Follicular; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogenicity Tests; Cell Survival; Cells, Cultured; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Female; Gene Expression; Glucuronosyltransferase; Hepatocytes; HIV Protease Inhibitors; Hyperplasia; Longevity; Male; Nelfinavir; Rats; Rats, Sprague-Dawley; RNA, Messenger; Species Specificity; Thyroid Gland; Thyroid Hormones; Thyroid Neoplasms; Thyroxine	2005

Article

Year

The HIV protease inhibitor nelfinavir down-regulates RET signaling and induces apoptosis in medullary thyroid cancer cells.

The Journal of clinical endocrinology and metabolism, 2014, Volume: 99, Issue:5

Topics: Adult; Aged; Apoptosis; Autophagy; Carcinoma, Medullary; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Endoplasmic Reticulum Stress; Female; HIV Protease Inhibitors; HSP90 Heat-Shock Proteins; Humans; Male; Middle Aged; Mutation; Nelfinavir; Oxidative Stress; Proto-Oncogene Proteins c-ret; Signal Transduction; Thyroid Neoplasms

2014

Increase in thyroid follicular cell tumors in nelfinavir-treated rats observed in a 2-year carcinogenicity study is consistent with a rat-specific mechanism of thyroid neoplasia.

Human & experimental toxicology, 2005, Volume: 24, Issue:12

Topics: Adenocarcinoma, Follicular; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Carcinogenicity Tests; Cell Survival; Cells, Cultured; Cytochrome P-450 CYP3A; Dose-Response Relationship, Drug; Female; Gene Expression; Glucuronosyltransferase; Hepatocytes; HIV Protease Inhibitors; Hyperplasia; Longevity; Male; Nelfinavir; Rats; Rats, Sprague-Dawley; RNA, Messenger; Species Specificity; Thyroid Gland; Thyroid Hormones; Thyroid Neoplasms; Thyroxine

2005