Compounds > nelfinavir
Page last updated: 2024-08-24

nelfinavir and Insulin Sensitivity

nelfinavir has been researched along with Insulin Sensitivity in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (11.11)18.2507
2000's6 (66.67)29.6817
2010's2 (22.22)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Haugaard, SB1
Bashan, N; Ben-Romano, R; Hou, JC; Kachko, I; Maissel, A; Mazor, L; Pessin, JE; Rudich, A; Watson, RT1
Anwar, K; Ismail, WI; King, JA; Pillay, TS1
Bashan, N; Ben-Romano, R; Klip, A; Riesenberg, K; Rudich, A; Schlaeffer, F; Török, D; Vanounou, S1
Bashan, N; Ben-Romano, R; Potashnik, R; Riesenberg, K; Rudich, A; Sasaoka, T; Schlaeffer, F; Tirosh, A1
Dubé, MP; Grinspoon, SK; Meyer, WA; Mulligan, K; Parker, RA; Robbins, GK; Roubenoff, R; Shafer, RW; Snyder, SW; Tebas, P; Wininger, DA; Zackin, RA1
Bashan, N; Ben-Romano, R; Etzion, S; Greenbaum, U; Kagan, E; Potashnik, R; Rudich, A1
Burton, S; Carr, A; Chisholm, DJ; Cooper, DA; Freund, J; Law, M; Samaras, K1
Bashan, N; Greenberg, AS; Harman-Boehm, I; Porat, M; Riesenberg, K; Rudich, A; Schlaeffer, F; Tirosh, A; Vanounou, S1

Reviews

1 review(s) available for nelfinavir and Insulin Sensitivity

ArticleYear
Alteration in pancreatic islet function in human immunodeficiency virus.
    Endocrinology and metabolism clinics of North America, 2014, Volume: 43, Issue:3

    Topics: Carbamates; Furans; HIV Protease Inhibitors; HIV-Associated Lipodystrophy Syndrome; Humans; Indinavir; Insulin; Insulin Resistance; Insulin Secretion; Insulin-Secreting Cells; Nelfinavir; Ritonavir; Sulfonamides

2014

Trials

1 trial(s) available for nelfinavir and Insulin Sensitivity

ArticleYear
Glucose metabolism, lipid, and body fat changes in antiretroviral-naive subjects randomized to nelfinavir or efavirenz plus dual nucleosides.
    AIDS (London, England), 2005, Nov-04, Volume: 19, Issue:16

    Topics: Absorptiometry, Photon; Adipose Tissue; Adult; Alkynes; Anti-HIV Agents; Benzoxazines; Blood Glucose; Cyclopropanes; Drug Therapy, Combination; Dyslipidemias; Female; HIV Infections; HIV-Associated Lipodystrophy Syndrome; Humans; Insulin Resistance; Lipids; Male; Nelfinavir; Nucleosides; Oxazines

2005

Other Studies

7 other study(ies) available for nelfinavir and Insulin Sensitivity

ArticleYear
Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate.
    Endocrinology, 2009, Volume: 150, Issue:6

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Membrane; Disease Models, Animal; Glucose; Glucose Transporter Type 4; Green Fluorescent Proteins; HIV Protease Inhibitors; Insulin; Insulin Resistance; Mice; Nelfinavir; Phosphatidylinositol Phosphates; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Signal Transduction

2009
Indinavir and nelfinavir inhibit proximal insulin receptor signaling and salicylate abrogates inhibition: potential role of the NFkappa B pathway.
    Journal of cellular biochemistry, 2013, Volume: 114, Issue:8

    Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Animals; Anti-Infective Agents; CHO Cells; Cricetinae; Cricetulus; HIV Protease Inhibitors; Humans; Indinavir; Insulin Receptor Substrate Proteins; Insulin Resistance; Mice; Nelfinavir; NF-kappa B; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptor, Insulin; Salicylic Acid; Signal Transduction

2013
Agent and cell-type specificity in the induction of insulin resistance by HIV protease inhibitors.
    AIDS (London, England), 2003, Jan-03, Volume: 17, Issue:1

    Topics: Adipocytes; Cell Line; Deoxyglucose; Drug Administration Schedule; Fibroblasts; Glucose Transporter Type 1; HIV Protease Inhibitors; Humans; Indinavir; Insulin Resistance; Lipolysis; Monosaccharide Transport Proteins; Muscle, Skeletal; Nelfinavir; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Saquinavir

2003
Nelfinavir-induced insulin resistance is associated with impaired plasma membrane recruitment of the PI 3-kinase effectors Akt/PKB and PKC-zeta.
    Diabetologia, 2004, Volume: 47, Issue:6

    Topics: 3-Phosphoinositide-Dependent Protein Kinases; 3T3-L1 Cells; Animals; Cell Membrane; Deoxyglucose; Drug Evaluation, Preclinical; Female; Glucose; Insulin Resistance; Japan; Mice; Nelfinavir; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases, 70-kDa; Signal Transduction; Time Factors

2004
Nelfinavir induces adipocyte insulin resistance through the induction of oxidative stress: differential protective effect of antioxidant agents.
    Antiviral therapy, 2006, Volume: 11, Issue:8

    Topics: 3T3-L1 Cells; Acetylcysteine; Adipocytes; Animals; Anti-HIV Agents; Antioxidants; Insulin; Insulin Resistance; Metalloporphyrins; Mice; Muscle, Smooth, Vascular; Nelfinavir; Oxidative Stress; Signal Transduction

2006
A syndrome of peripheral lipodystrophy, hyperlipidaemia and insulin resistance in patients receiving HIV protease inhibitors.
    AIDS (London, England), 1998, May-07, Volume: 12, Issue:7

    Topics: Adult; Anti-HIV Agents; Body Composition; Cross-Sectional Studies; Diabetes Mellitus; Female; HIV Infections; HIV Protease Inhibitors; Humans; Hyperlipidemias; Indinavir; Insulin Resistance; Lipodystrophy; Male; Nelfinavir; Risk Factors; Ritonavir; Saquinavir; Syndrome

1998
The HIV protease inhibitor nelfinavir induces insulin resistance and increases basal lipolysis in 3T3-L1 adipocytes.
    Diabetes, 2001, Volume: 50, Issue:6

    Topics: 3T3 Cells; Adipocytes; Animals; Biological Transport; Glucose; Glucose Transporter Type 4; HIV Protease Inhibitors; Insulin Resistance; Lipolysis; Mice; Monosaccharide Transport Proteins; Muscle Proteins; Nelfinavir; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt

2001