nefopam has been researched along with Postoperative Complications in 15 studies
Nefopam: Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)
nefopam : A racemate comprising equal amounts of (R)- and (S)-nefopam. The hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.
5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine : A member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively.
Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "3-mg/kg bolus of nefopam at the induction of anesthesia followed by a continuous infusion of 0." | 5.17 | Effects of nefopam on early postoperative hyperalgesia after cardiac surgery. ( Branchard, O; Cahana, A; Janvier, G; Jelacic, S; Leproust, S; Picard, W; Richebé, P; Rivat, C, 2013) |
| "We evaluated the haemodynamic and metabolic effects of prevention of shivering after prophylactic nefopam administration in neurosurgical patients undergoing craniotomy and mild systemic hypothermia (33-35 degrees C)." | 5.09 | Effects of shivering prevention on haemodynamic and metabolic demands in hypothermic postoperative neurosurgical patients. ( Bilotta, F; La Rosa, I; Pietropaoli, P; Rosa, G; Spinelli, F, 2001) |
| "Physostigmine is a safe alternative to nefopam, significantly reducing the incidence and severity of postanaesthetic shivering without affecting postanaesthetic recovery." | 2.71 | Physostigmine for the prevention of postanaesthetic shivering following general anaesthesia - a placebo-controlled comparison with nefopam. ( Boldt, J; Piper, SN; Riechmann, J; Röhm, KD; Schuler, S; Suttner, SW, 2005) |
| "Nefopam induced agitation and confusion associated with anticholinergic symptoms such as tremor, hypertonia, mydriasis, and tachycardia." | 1.31 | [A new cause of postoperative confusion syndrome: nefopam]. ( Babinet, A; Bonnet, F; el Metaoua, S; Fulgencio, JP; Godier, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (13.33) | 18.7374 |
| 1990's | 3 (20.00) | 18.2507 |
| 2000's | 7 (46.67) | 29.6817 |
| 2010's | 3 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matsota,, PK | 1 |
| Koliantzaki,, IK | 1 |
| Kostopanagiotou, GG | 1 |
| Corbonnois, G | 1 |
| Iohom, G | 1 |
| Lazarescu, C | 1 |
| Hubert, I | 1 |
| Bouaziz, H | 1 |
| Richebé, P | 1 |
| Picard, W | 1 |
| Rivat, C | 1 |
| Jelacic, S | 1 |
| Branchard, O | 1 |
| Leproust, S | 1 |
| Cahana, A | 1 |
| Janvier, G | 1 |
| Godier, A | 1 |
| Babinet, A | 1 |
| el Metaoua, S | 1 |
| Fulgencio, JP | 1 |
| Bonnet, F | 1 |
| Bilotta, F | 3 |
| Rosa, G | 3 |
| Piper, SN | 3 |
| Röhm, KD | 2 |
| Suttner, SW | 3 |
| Maleck, WH | 2 |
| Kranke, P | 2 |
| Boldt, J | 3 |
| Eberhart, LH | 1 |
| Roewer, N | 1 |
| Tramèr, MR | 1 |
| Riechmann, J | 1 |
| Schuler, S | 1 |
| Wilkinson, PA | 1 |
| Ferri, L | 1 |
| Bertelli, G | 1 |
| Innocenti, S | 1 |
| Di Grancio, R | 1 |
| Tinagli, F | 1 |
| Schmidt, CC | 1 |
| Kumle, B | 1 |
| Triem, JG | 1 |
| Pietropaoli, P | 2 |
| La Rosa, I | 1 |
| Spinelli, F | 1 |
| Molina, FJ | 1 |
| Nanut, EF | 1 |
| Sancho, RC | 1 |
| Dunan, GB | 1 |
| Scalogna, JV | 1 |
| Tempia, A | 1 |
| Livigni, S | 1 |
| Castino, PM | 1 |
| Fiore, G | 1 |
| De Caroli, D | 1 |
| Pattono, R | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Study of the Effects of Nefopam on Hyperalgesia Following Sternotomy in Cardiac Surgery[NCT00413257] | Phase 2/Phase 3 | 90 participants (Actual) | Interventional | 2006-12-31 | Completed | ||
| A Double-blind Placebo-controlled Evaluation of Ropivacaine Efficacy by Local Per and Post Hepatectomy Infiltrations for Adult Pain Management[NCT01194843] | 85 participants (Actual) | Interventional | 2009-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for nefopam and Postoperative Complications
| Article | Year |
|---|---|
Pharmacological Approach for the Prevention of Postoperative Shivering: A Systematic Review of Prospective Randomized Controlled Trials
Topics: Adrenergic alpha-2 Receptor Agonists; Humans; Nefopam; Postoperative Complications; Prospective Stud | 2019 |
Single-dose parenteral pharmacological interventions for the prevention of postoperative shivering: a quantitative systematic review of randomized controlled trials.
Topics: Clonidine; Dose-Response Relationship, Drug; Humans; Nefopam; Postoperative Complications; Randomize | 2004 |
Nefopam for refractory postoperative hiccups.
Topics: Aged; Analgesics, Non-Narcotic; Female; Hiccup; Humans; Male; Middle Aged; Nefopam; Postoperative Co | 2001 |
9 trials available for nefopam and Postoperative Complications
| Article | Year |
|---|---|
Effects of nefopam on early postoperative hyperalgesia after cardiac surgery.
Topics: Aged; Analgesics, Non-Narcotic; Anesthesia; Cardiac Surgical Procedures; Coronary Artery Bypass; Dou | 2013 |
A comparison of nefopam and clonidine for the prevention of postanaesthetic shivering: a comparative, double-blind and placebo-controlled dose-ranging study.
Topics: Adult; Aged; Analgesics; Analgesics, Non-Narcotic; Anesthesia, General; Blood Pressure; Body Tempera | 2004 |
Physostigmine for the prevention of postanaesthetic shivering following general anaesthesia - a placebo-controlled comparison with nefopam.
Topics: Adult; Aged; Analgesics; Anesthesia, General; Blood Pressure; Cholinesterase Inhibitors; Double-Blin | 2005 |
A double-blind comparison of nefopam and placebo used as a premedication in children.
Topics: Adolescent; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Humans; | 1984 |
[The treatment of postoperative shivering with nefopam hydrochloride].
Topics: Adolescent; Adult; Aged; Chi-Square Distribution; Female; Humans; Male; Middle Aged; Nefopam; Postop | 1993 |
[Prophylactic nefopam administration for post-anesthetic shivering].
Topics: Analgesics, Non-Narcotic; Anesthesia, Inhalation; Anesthetics, Inhalation; Blood Pressure; Double-Bl | 1998 |
Effects of shivering prevention on haemodynamic and metabolic demands in hypothermic postoperative neurosurgical patients.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Blood Pressure; Craniotomy; Double-Blind Method; Female; Hear | 2001 |
[Experience with nefopam hydrochlorate, a new analgesic in postoperative recovery].
Topics: Adult; Cholecystectomy; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Female; Huma | 1977 |
[The use of nefopam in the prophylaxis and treatment of postoperative shivering].
Topics: Adult; Aged; Female; Humans; Male; Middle Aged; Nefopam; Postoperative Complications; Shivering | 1992 |
3 other studies available for nefopam and Postoperative Complications
| Article | Year |
|---|---|
Unilateral permanent loss of vision after nefopam administration.
Topics: Aged; Analgesics, Non-Narcotic; Anesthesia, General; Arthroplasty, Replacement, Knee; Blindness; Fem | 2013 |
[A new cause of postoperative confusion syndrome: nefopam].
Topics: Analgesics, Non-Narcotic; Confusion; Critical Care; Female; Humans; Intestinal Neoplasms; Middle Age | 2002 |
Pharmacological prevention of postanesthetic shivering.
Topics: Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Antiemetics; Clonidine; Humans; Indoles; Nefopa | 2002 |