Page last updated: 2024-10-31

nefopam and Neuralgia

nefopam has been researched along with Neuralgia in 7 studies

Nefopam: Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)
nefopam : A racemate comprising equal amounts of (R)- and (S)-nefopam. The hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.
5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine : A member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively.

Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.

Research Excerpts

ExcerptRelevanceReference
"Nefopam is a non-opioid, non-nonsteroidal anti-imflammatory drug, analgesic drug that inhibits the reuptake of serotonin, norepinephrine, and dopamine."3.11Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial. ( Homprasert, C; Nitising, A; Pantubtim, C; Raksakietisak, M; Rushatamukayanunt, P; Sawasdiwipachai, P; Wilaiwan, K, 2022)
"Ketamine and nefopam has been documented to decrease pain intensity and improve rehabilitation after total knee arthroplasty (TKA)."2.79Pain and recovery after total knee arthroplasty: a 12-month follow-up after a prospective randomized study evaluating Nefopam and Ketamine for early rehabilitation. ( Aveline, C; Bonnet, F; Cognet, F; Gautier, JF; Hetet, HL; Roux, AL; Vautier, P, 2014)
"Nefopam has shown potential for reducing neuropathic pain, but the underlying mechanisms are unknown."1.48Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation. ( Jee, IG; Jung, KT; Lim, KJ; Oh, SH; Yoon, MH; Yu, BS, 2018)
"Nefopam hydrochloride is a centrally acting compound that induces antinociceptive and antihyperalgesic properties in neuropathic pain models."1.43The Antiallodynic Effects of Nefopam Are Mediated by the Adenosine Triphosphate-Sensitive Potassium Channel in a Neuropathic Pain Model. ( Bang, JY; Kim, SG; Koh, WU; Shin, JW; Song, JG, 2016)
"Nefopam has a pharmacologic profile distinct from that of opioids or other anti-inflammatory drugs."1.42Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model. ( Baek, SH; Byeon, GJ; Kim, HY; Kim, KH; Koo, ST; Shin, SW, 2015)
"Nefopam is a non-opioid analgesic drug, used widely in European countries to control postoperative pain."1.40Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats. ( Dam, LJ; Ha, YM; Hai, L, 2014)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Raksakietisak, M1
Rushatamukayanunt, P1
Wilaiwan, K1
Homprasert, C1
Nitising, A1
Sawasdiwipachai, P1
Pantubtim, C1
Capuco, A1
Urits, I1
Orhurhu, V1
Chun, R1
Shukla, B1
Burke, M1
Kaye, RJ1
Garcia, AJ1
Kaye, AD1
Viswanath, O1
Oh, SH1
Yoon, MH1
Lim, KJ1
Yu, BS1
Jee, IG1
Jung, KT1
Aveline, C1
Roux, AL1
Hetet, HL1
Gautier, JF1
Vautier, P1
Cognet, F1
Bonnet, F1
Dam, LJ1
Hai, L1
Ha, YM1
Kim, KH1
Byeon, GJ1
Kim, HY1
Baek, SH1
Shin, SW1
Koo, ST1
Koh, WU1
Shin, JW1
Bang, JY1
Kim, SG1
Song, JG1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluation of the Efficacy of Perioperative Administration of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. A Double-Blinded Randomized Controlled Trial.[NCT05935059]90 participants (Anticipated)Interventional2023-06-21Recruiting
Effect of Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Block on the Incidence of Post Mastectomy Pain Syndrome, Randomized Double Blinded Controlled Study[NCT05201963]120 participants (Anticipated)Interventional2021-11-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for nefopam and Neuralgia

ArticleYear
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
    Current pain and headache reports, 2020, Jun-11, Volume: 24, Issue:8

    Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres

2020
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
    Current pain and headache reports, 2020, Jun-11, Volume: 24, Issue:8

    Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres

2020
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
    Current pain and headache reports, 2020, Jun-11, Volume: 24, Issue:8

    Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres

2020
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
    Current pain and headache reports, 2020, Jun-11, Volume: 24, Issue:8

    Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres

2020

Trials

2 trials available for nefopam and Neuralgia

ArticleYear
Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial.
    Medicine, 2022, Oct-28, Volume: 101, Issue:43

    Topics: Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Cervical Vertebrae; Double-Blind Method; Dr

2022
Pain and recovery after total knee arthroplasty: a 12-month follow-up after a prospective randomized study evaluating Nefopam and Ketamine for early rehabilitation.
    The Clinical journal of pain, 2014, Volume: 30, Issue:9

    Topics: Aged; Analgesics; Arthroplasty, Replacement, Knee; Chronic Pain; Female; Follow-Up Studies; Humans;

2014

Other Studies

4 other studies available for nefopam and Neuralgia

ArticleYear
Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation.
    BMC anesthesiology, 2018, 07-27, Volume: 18, Issue:1

    Topics: Animals; Autophagy; Capsaicin; Cell Line, Tumor; Down-Regulation; Humans; JNK Mitogen-Activated Prot

2018
Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats.
    Neuroscience letters, 2014, Apr-30, Volume: 566

    Topics: Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spina

2014
Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model.
    Journal of Korean medical science, 2015, Volume: 30, Issue:8

    Topics: Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spina

2015
The Antiallodynic Effects of Nefopam Are Mediated by the Adenosine Triphosphate-Sensitive Potassium Channel in a Neuropathic Pain Model.
    Anesthesia and analgesia, 2016, Volume: 123, Issue:3

    Topics: Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Hyperalgesia; KATP Channels; Male; Nefopa

2016