nefopam has been researched along with Neuralgia in 7 studies
Nefopam: Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)
nefopam : A racemate comprising equal amounts of (R)- and (S)-nefopam. The hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.
5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine : A member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively.
Neuralgia: Intense or aching pain that occurs along the course or distribution of a peripheral or cranial nerve.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nefopam is a non-opioid, non-nonsteroidal anti-imflammatory drug, analgesic drug that inhibits the reuptake of serotonin, norepinephrine, and dopamine." | 3.11 | Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial. ( Homprasert, C; Nitising, A; Pantubtim, C; Raksakietisak, M; Rushatamukayanunt, P; Sawasdiwipachai, P; Wilaiwan, K, 2022) |
| "Ketamine and nefopam has been documented to decrease pain intensity and improve rehabilitation after total knee arthroplasty (TKA)." | 2.79 | Pain and recovery after total knee arthroplasty: a 12-month follow-up after a prospective randomized study evaluating Nefopam and Ketamine for early rehabilitation. ( Aveline, C; Bonnet, F; Cognet, F; Gautier, JF; Hetet, HL; Roux, AL; Vautier, P, 2014) |
| "Nefopam has shown potential for reducing neuropathic pain, but the underlying mechanisms are unknown." | 1.48 | Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation. ( Jee, IG; Jung, KT; Lim, KJ; Oh, SH; Yoon, MH; Yu, BS, 2018) |
| "Nefopam hydrochloride is a centrally acting compound that induces antinociceptive and antihyperalgesic properties in neuropathic pain models." | 1.43 | The Antiallodynic Effects of Nefopam Are Mediated by the Adenosine Triphosphate-Sensitive Potassium Channel in a Neuropathic Pain Model. ( Bang, JY; Kim, SG; Koh, WU; Shin, JW; Song, JG, 2016) |
| "Nefopam has a pharmacologic profile distinct from that of opioids or other anti-inflammatory drugs." | 1.42 | Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model. ( Baek, SH; Byeon, GJ; Kim, HY; Kim, KH; Koo, ST; Shin, SW, 2015) |
| "Nefopam is a non-opioid analgesic drug, used widely in European countries to control postoperative pain." | 1.40 | Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats. ( Dam, LJ; Ha, YM; Hai, L, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (71.43) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Raksakietisak, M | 1 |
| Rushatamukayanunt, P | 1 |
| Wilaiwan, K | 1 |
| Homprasert, C | 1 |
| Nitising, A | 1 |
| Sawasdiwipachai, P | 1 |
| Pantubtim, C | 1 |
| Capuco, A | 1 |
| Urits, I | 1 |
| Orhurhu, V | 1 |
| Chun, R | 1 |
| Shukla, B | 1 |
| Burke, M | 1 |
| Kaye, RJ | 1 |
| Garcia, AJ | 1 |
| Kaye, AD | 1 |
| Viswanath, O | 1 |
| Oh, SH | 1 |
| Yoon, MH | 1 |
| Lim, KJ | 1 |
| Yu, BS | 1 |
| Jee, IG | 1 |
| Jung, KT | 1 |
| Aveline, C | 1 |
| Roux, AL | 1 |
| Hetet, HL | 1 |
| Gautier, JF | 1 |
| Vautier, P | 1 |
| Cognet, F | 1 |
| Bonnet, F | 1 |
| Dam, LJ | 1 |
| Hai, L | 1 |
| Ha, YM | 1 |
| Kim, KH | 1 |
| Byeon, GJ | 1 |
| Kim, HY | 1 |
| Baek, SH | 1 |
| Shin, SW | 1 |
| Koo, ST | 1 |
| Koh, WU | 1 |
| Shin, JW | 1 |
| Bang, JY | 1 |
| Kim, SG | 1 |
| Song, JG | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Efficacy of Perioperative Administration of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. A Double-Blinded Randomized Controlled Trial.[NCT05935059] | 90 participants (Anticipated) | Interventional | 2023-06-21 | Recruiting | |||
| Effect of Ultrasound Guided Erector Spinae Plane Block Versus Ultrasound Guided Serratus Anterior Block on the Incidence of Post Mastectomy Pain Syndrome, Randomized Double Blinded Controlled Study[NCT05201963] | 120 participants (Anticipated) | Interventional | 2021-11-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for nefopam and Neuralgia
| Article | Year |
|---|---|
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres | 2020 |
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres | 2020 |
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres | 2020 |
A Comprehensive Review of the Diagnosis, Treatment, and Management of Postmastectomy Pain Syndrome.
Topics: Acetylcholine Release Inhibitors; Analgesics; Anesthesia, Conduction; Anesthetics, Local; Antidepres | 2020 |
2 trials available for nefopam and Neuralgia
| Article | Year |
|---|---|
Postoperative analgesia of intraoperative nefopam in patients undergoing anterior cervical spine surgery: A prospective randomized controlled trial.
Topics: Analgesia; Analgesics, Non-Narcotic; Analgesics, Opioid; Cervical Vertebrae; Double-Blind Method; Dr | 2022 |
Pain and recovery after total knee arthroplasty: a 12-month follow-up after a prospective randomized study evaluating Nefopam and Ketamine for early rehabilitation.
Topics: Aged; Analgesics; Arthroplasty, Replacement, Knee; Chronic Pain; Female; Follow-Up Studies; Humans; | 2014 |
4 other studies available for nefopam and Neuralgia
| Article | Year |
|---|---|
Nefopam downregulates autophagy and c-Jun N-terminal kinase activity in the regulation of neuropathic pain development following spinal nerve ligation.
Topics: Animals; Autophagy; Capsaicin; Cell Line, Tumor; Down-Regulation; Humans; JNK Mitogen-Activated Prot | 2018 |
Role of the 5-HT(7) receptor in the effects of intrathecal nefopam in neuropathic pain in rats.
Topics: Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spina | 2014 |
Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model.
Topics: Analgesics, Non-Narcotic; Animals; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Spina | 2015 |
The Antiallodynic Effects of Nefopam Are Mediated by the Adenosine Triphosphate-Sensitive Potassium Channel in a Neuropathic Pain Model.
Topics: Analgesics, Non-Narcotic; Animals; Disease Models, Animal; Hyperalgesia; KATP Channels; Male; Nefopa | 2016 |