nefopam has been researched along with Ache in 30 studies
Nefopam: Non-narcotic analgesic chemically similar to ORPHENADRINE. Its mechanism of action is unclear. It is used for the relief of acute and chronic pain. (From Martindale, The Extra Pharmacopoeia, 30th ed, p26)
nefopam : A racemate comprising equal amounts of (R)- and (S)-nefopam. The hydrochloride is a centrally acting non-opiate analgesic commonly used for the treatment of moderate to severe pain.
5-methyl-1-phenyl-3,4,5,6-tetrahydro-1H-2,5-benzoxazocine : A member of the class of benzoxazocines that is 3,4,5,6-tetrahydro-1H-2,5-benzoxazocine substituted by phenyl and methyl groups at positions 1 and 5 respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We aimed to investigate the frequency and severity of pain associated with intravenous injection of nefopam and to determine whether a slow rate of administration can effectively reduce such pain." | 9.19 | Slow injection of nefopam reduces pain intensity associated with intravenous injection: a prospective randomized trial. ( Kim, H; Kim, YM; Kong, MH; Lee, IO; Lee, MK; Lim, BG, 2014) |
| "Given preemptively, nefopam may be effective at improving postoperative pain management and at reducing the risk of developing postoperative chronic pain, because the drug has both analgesic and antihyperalgesic properties." | 7.75 | Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. ( Chateauraynaud, J; Laboureyras, E; Richebé, P; Simonnet, G, 2009) |
| "Nefopam is a central analgesic, with non-opiate action and, because of this inscribed by the WHO in the first grade, but with an analgesic capacity that corresponds to the substances of grade II analgesics." | 5.32 | [The management of acute pain in ambulatory patients. The place of nefopam]. ( Dacero, JP, 2004) |
| "We aimed to investigate the frequency and severity of pain associated with intravenous injection of nefopam and to determine whether a slow rate of administration can effectively reduce such pain." | 5.19 | Slow injection of nefopam reduces pain intensity associated with intravenous injection: a prospective randomized trial. ( Kim, H; Kim, YM; Kong, MH; Lee, IO; Lee, MK; Lim, BG, 2014) |
| "A single slow infusion of nefopam is effective in critically ill patients who have moderate pain." | 5.15 | Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients. ( Chanques, G; Cissé, M; Constantin, JM; Jaber, S; Jung, B; Lefrant, JY; Ramillon, N; Sebbane, M, 2011) |
| "The efficacy of nefopam, a novel analgesic agent, was compared to pentazocine in a double blind study in 40 cancer patients with chronic pain." | 5.04 | [Analgesia with mild side effects]. ( Schietzel, M, 1977) |
| " A comparison was made of morphine and nefopam in 74 patients who required parenteral analgesia for moderate to severe postoperative and somatic pain, using a single administration, 2-dose level, double-blind design." | 5.04 | Nefopam and morphine in man. ( Laska, E; Sunshine, A, 1975) |
| "The results of a controlled, double-blind clinical trial are reported demonstrating the potency of analgesia produced by orally and parenterally administered nefopam HCl in hospitalized patients with pain principally of skeletal and neuromuscular origin." | 5.04 | Controlled clinical trial of oral and parenteral nefopam hydrochloride. A novel and potent analgesic drug. ( Ballesteros, ML; Diamantopoulos, E; Gassel, MM; Hughes, AC; Petropoulos, V; Ré, ON, 1976) |
| "Based on 3 small trials, which were all at high risk of bias, there is weak evidence that nefopam and capsaicin are superior to placebo in reducing pain in patients with RA, but both are associated with a significant side effect profile." | 4.88 | Efficacy and safety of neuromodulators in inflammatory arthritis: a Cochrane systematic review. ( Buchbinder, R; Richards, BL; van der Heijde, DM; Whittle, SL, 2012) |
| "The present study investigated the effects of intrathecal nefopam on the pain behavior and on the extracellular levels of serotonin (5-HT), norepinephrine (NE), and glutamate in the spinal cord, in a rat model of pain induced by formalin." | 3.96 | Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord. ( Chae, JW; Choi, JI; Kang, DH; Kim, SH; Kim, WM; Lee, HG; Li, Y; Yoon, MH, 2020) |
| "Given preemptively, nefopam may be effective at improving postoperative pain management and at reducing the risk of developing postoperative chronic pain, because the drug has both analgesic and antihyperalgesic properties." | 3.75 | Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties. ( Chateauraynaud, J; Laboureyras, E; Richebé, P; Simonnet, G, 2009) |
| " Based on a clinical observation of synergism between nefopam, a centrally acting non-opioid that inhibits monoamines reuptake, and ketoprofen, a non-steroidal anti-inflammatory drug, the objective of this study was to further explore this antinociceptive synergy in four distinct animal models of pain (both drugs were administered subcutaneously)." | 3.74 | Nefopam and ketoprofen synergy in rodent models of antinociception. ( Coppé, MC; Gillardin, JM; Girard, P; Pansart, Y; Verniers, D, 2008) |
| "Nefopam hydrochloride has been commercialized as an analgesic drug in most Western European countries for 20 years." | 2.69 | Nefopam strongly depresses the nociceptive flexion (R(III)) reflex in humans. ( Bouhassira, D; Brasseur, L; Chauvin, M; Dupont, X; Guirimand, F, 1999) |
| "Aspirin 600 mg was significantly different from placebo (p less than 0-05) at all hourly observations for both efficacy parameters, as was nefopam 30 mg (p less than 0-01)." | 2.64 | Nefopam hydrochloride: new analgesic agent. ( Cohen, A; Hernandez, CM, 1976) |
| "Pain is an unpleasant sensation that originates from ongoing or impending tissue damage." | 2.44 | Recent advances in the pharmacological management of pain. ( Beaulieu, P; Guindon, J; Walczak, JS, 2007) |
| "In a rat incision model of postoperative thermal hyperalgesia, coadministration of nefopam at a non-analgesic dose (3 mg/kg) with paracetamol at a low analgesic dose (300 mg/kg) showed the appearance of a strong antihyperalgesic effect, maintained for at least 3 h." | 1.37 | Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception. ( Coppé, MC; Girard, P; Niedergang, B; Pansart, Y; Verleye, M, 2011) |
| "Nefopam is a central analgesic, with non-opiate action and, because of this inscribed by the WHO in the first grade, but with an analgesic capacity that corresponds to the substances of grade II analgesics." | 1.32 | [The management of acute pain in ambulatory patients. The place of nefopam]. ( Dacero, JP, 2004) |
| "Pretreatment with reserpine (2 mg/kg) significantly reduced the antinociceptive activity of FR64822, when tested against acetic acid writhing." | 1.28 | Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound. ( Nomura, K; Ohkubo, Y; Yamaguchi, I, 1991) |
| "Nefopam is a centrally (but not spinally) acting analgesic with a novel activity profile." | 1.27 | Control of cancer pain with analgesics acting in the central nervous system. ( Wörz, R, 1984) |
| "Nefopam was administered by the intraperitoneal, intracerebroventricular (i." | 1.27 | Antinociceptive effects of (+/-)-, (+)- and (-)-nefopam in mice. ( Berge, OG; Fasmer, OB; Hole, K; Jørgensen, HA, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (43.33) | 18.7374 |
| 1990's | 3 (10.00) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 5 (16.67) | 24.3611 |
| 2020's | 2 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Banting, M | 1 |
| Chae, JW | 1 |
| Kang, DH | 1 |
| Li, Y | 1 |
| Kim, SH | 1 |
| Lee, HG | 2 |
| Choi, JI | 2 |
| Yoon, MH | 1 |
| Kim, WM | 2 |
| Kim, YM | 1 |
| Lim, BG | 1 |
| Kim, H | 1 |
| Kong, MH | 1 |
| Lee, MK | 1 |
| Lee, IO | 1 |
| Kim, JM | 1 |
| Bae, HB | 1 |
| Laboureyras, E | 1 |
| Chateauraynaud, J | 1 |
| Richebé, P | 1 |
| Simonnet, G | 1 |
| Chanques, G | 1 |
| Sebbane, M | 1 |
| Constantin, JM | 1 |
| Ramillon, N | 1 |
| Jung, B | 1 |
| Cissé, M | 1 |
| Lefrant, JY | 1 |
| Jaber, S | 1 |
| Girard, P | 2 |
| Niedergang, B | 1 |
| Pansart, Y | 2 |
| Coppé, MC | 2 |
| Verleye, M | 1 |
| Richards, BL | 1 |
| Whittle, SL | 1 |
| van der Heijde, DM | 1 |
| Buchbinder, R | 1 |
| Villier, C | 1 |
| Mallaret, MP | 1 |
| Dacero, JP | 1 |
| Guindon, J | 1 |
| Walczak, JS | 1 |
| Beaulieu, P | 1 |
| Verniers, D | 1 |
| Gillardin, JM | 1 |
| Wörz, R | 1 |
| Kanui, TI | 1 |
| Karim, F | 1 |
| Towett, PK | 1 |
| Guirimand, F | 1 |
| Dupont, X | 1 |
| Bouhassira, D | 1 |
| Brasseur, L | 1 |
| Chauvin, M | 1 |
| Evtiukhin, AI | 1 |
| Kuznetsova, OIu | 1 |
| Gorokhov, LV | 1 |
| Dunaevskiĭ, IV | 1 |
| Buritova, J | 1 |
| Besson, JM | 1 |
| Schietzel, M | 1 |
| Wang, RI | 1 |
| Waite, EM | 1 |
| Wade, AG | 1 |
| Hosie, J | 1 |
| Cronheim, G | 1 |
| Thiede, W | 1 |
| Cohen, A | 1 |
| Hernandez, CM | 1 |
| Kolodny, AL | 1 |
| Winter, L | 1 |
| de Thibault de Boesinghe, L | 1 |
| Van Daele, MJ | 1 |
| Van Severen, G | 1 |
| Sunshine, A | 1 |
| Laska, E | 1 |
| Gassel, MM | 1 |
| Diamantopoulos, E | 1 |
| Petropoulos, V | 1 |
| Hughes, AC | 1 |
| Ballesteros, ML | 1 |
| Ré, ON | 1 |
| Ohkubo, Y | 1 |
| Nomura, K | 1 |
| Yamaguchi, I | 1 |
| Minotti, V | 1 |
| Patoia, L | 1 |
| Roila, F | 1 |
| Basurto, C | 1 |
| Tonato, M | 1 |
| Pasqualucci, V | 1 |
| Maresca, V | 1 |
| Del Favero, A | 1 |
| Fasmer, OB | 1 |
| Berge, OG | 1 |
| Jørgensen, HA | 1 |
| Hole, K | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| [NCT01833728] | 16 participants (Actual) | Interventional | 2013-04-30 | Completed | |||
| A Double-blind Placebo-controlled Evaluation of Ropivacaine Efficacy by Local Per and Post Hepatectomy Infiltrations for Adult Pain Management[NCT01194843] | 85 participants (Actual) | Interventional | 2009-03-31 | Completed | |||
| Analgesic Effectiveness of Nefopam in Patients Undergoing Anterior Cervical Spine Surgery[NCT03955705] | 50 participants (Anticipated) | Interventional | 2019-05-15 | Enrolling by invitation | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for nefopam and Ache
| Article | Year |
|---|---|
Efficacy and safety of neuromodulators in inflammatory arthritis: a Cochrane systematic review.
Topics: Analgesics, Non-Narcotic; Arthritis; Capsaicin; Evidence-Based Medicine; Expert Testimony; Humans; I | 2012 |
Recent advances in the pharmacological management of pain.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Anesthetics, Local; Animals | 2007 |
12 trials available for nefopam and Ache
| Article | Year |
|---|---|
Slow injection of nefopam reduces pain intensity associated with intravenous injection: a prospective randomized trial.
Topics: Adult; Aged; Analgesics, Non-Narcotic; Female; Humans; Injections, Intravenous; Male; Middle Aged; N | 2014 |
Analgesic efficacy and haemodynamic effects of nefopam in critically ill patients.
Topics: Analgesics, Non-Narcotic; Cardiac Output; Critical Care; Critical Illness; Female; Heart Rate; Hemod | 2011 |
Nefopam strongly depresses the nociceptive flexion (R(III)) reflex in humans.
Topics: Adult; Analgesics, Non-Narcotic; Cross-Over Studies; Double-Blind Method; Electric Stimulation; Elec | 1999 |
[The use of Oxadol in tablet form for the treatment of chronic pain syndrome in late-stage cancer patients].
Topics: Administration, Oral; Aged; Analgesics, Non-Narcotic; Analgesics, Opioid; Chronic Disease; Drug Ther | 2000 |
[Analgesia with mild side effects].
Topics: Analgesia; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Nefopam; Neoplasm | 1977 |
The clinical analgesic efficacy of oral nefopam hydrochloride.
Topics: Adult; Aspirin; Double-Blind Method; Female; Humans; Male; Nefopam; Oxazocines; Pain; Placebos; Time | 1979 |
Nefopam hydrochloride: new analgesic agent.
Topics: Analgesics; Aspirin; Clinical Trials as Topic; Drug Evaluation; Humans; Male; Nefopam; Oxazocines; P | 1976 |
Further clinical evaluations of nefopam hydrochloride, a new analgesic.
Topics: Adult; Aspirin; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Muscular Diseases; Nefo | 1975 |
Open study of the analgesic effects of nefopam hydrochloride (Acupan) on cancer patients with pain.
Topics: Clinical Trials as Topic; Humans; Nefopam; Neoplasms; Oxazocines; Pain | 1976 |
Nefopam and morphine in man.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Middle Aged; Morphine; Nefopam; Oxazoci | 1975 |
Controlled clinical trial of oral and parenteral nefopam hydrochloride. A novel and potent analgesic drug.
Topics: Adult; Aged; Clinical Trials as Topic; Female; Humans; Male; Meperidine; Middle Aged; Nefopam; Oxazo | 1976 |
Double-blind evaluation of analgesic efficacy of orally administered diclofenac, nefopam, and acetylsalicylic acid (ASA) plus codeine in chronic cancer pain.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Analgesics; Aspirin; Chronic Disea | 1989 |
16 other studies available for nefopam and Ache
| Article | Year |
|---|---|
Enteral nefopam for pain control at the end of life.
Topics: Analgesics, Non-Narcotic; Death; Double-Blind Method; Humans; Nefopam; Pain; Pain Management | 2023 |
Antinociceptive effects of nefopam modulating serotonergic, adrenergic, and glutamatergic neurotransmission in the spinal cord.
Topics: Animals; Formaldehyde; Glutamic Acid; Male; Nefopam; Norepinephrine; Pain; Serotonin; Serotonin Anta | 2020 |
Intrathecal nefopam-induced antinociception through activation of descending serotonergic projections involving spinal 5-HT7 but not 5-HT3 receptors.
Topics: Analgesics; Animals; Injections, Spinal; Male; Nefopam; Ondansetron; Pain; Phenols; Rats, Sprague-Da | 2015 |
Long-term pain vulnerability after surgery in rats: prevention by nefopam, an analgesic with antihyperalgesic properties.
Topics: Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Carrageenan; Chronic Disease; Fentanyl; Hyper | 2009 |
Systematic evaluation of the nefopam-paracetamol combination in rodent models of antinociception.
Topics: Acetaminophen; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Disease Models, An | 2011 |
Nefopam abuse.
Topics: Adult; Analgesics, Non-Narcotic; Female; Humans; Injections, Intramuscular; Injections, Intravenous; | 2002 |
[The management of acute pain in ambulatory patients. The place of nefopam].
Topics: Acute Disease; Adult; Aged; Analgesics, Non-Narcotic; Child; Emergencies; Female; Humans; Injections | 2004 |
Nefopam and ketoprofen synergy in rodent models of antinociception.
Topics: Acetic Acid; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Behavior, A | 2008 |
Control of cancer pain with analgesics acting in the central nervous system.
Topics: Adult; Aged; Analgesics, Opioid; Buprenorphine; Female; Humans; Male; Middle Aged; Morphine; Nefopam | 1984 |
[Nefopam].
Topics: Humans; Nefopam; Oxazocines; Pain | 1981 |
The formalin test in the naked mole-rat (Heterocephalus glaber): analgesic effects of morphine, nefopam and paracetamol.
Topics: Acetaminophen; Analgesics; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Formalde | 1993 |
Effects of nefopam on the spinal nociceptive processes: a c-Fos protein study in the rat.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Anesthesia; Animals; Edema; Formaldehyde; Hot Temper | 2002 |
A new oral analgesic in general practice.
Topics: Adolescent; Adult; Aged; Evaluation Studies as Topic; Family Practice; Female; Humans; Male; Middle | 1979 |
[An analgesic: Ajan].
Topics: Acute Disease; Analgesics; Chronic Disease; Female; Humans; Male; Nefopam; Oxazocines; Pain | 1979 |
Involvement of dopamine in the mechanism of action of FR64822, a novel non-opioid antinociceptive compound.
Topics: Acetates; Acetic Acid; Analgesics; Animals; Clonidine; Dopamine; Dopamine Antagonists; Male; Mice; M | 1991 |
Antinociceptive effects of (+/-)-, (+)- and (-)-nefopam in mice.
Topics: Analysis of Variance; Animals; Dose-Response Relationship, Drug; Injections, Intraventricular; Male; | 1987 |