Page last updated: 2024-10-31

nefazodone and Substance Withdrawal Syndrome

nefazodone has been researched along with Substance Withdrawal Syndrome in 13 studies

nefazodone: may be useful as an opiate adjunct

Substance Withdrawal Syndrome: Physiological and psychological symptoms associated with withdrawal from the use of a drug after prolonged administration or habituation. The concept includes withdrawal from smoking or drinking, as well as withdrawal from an administered drug.

Research Excerpts

ExcerptRelevanceReference
"Nefazodone, which is an antidepressant with sedative properties, may attenuate symptoms of marijuana withdrawal."2.71Nefazodone decreases anxiety during marijuana withdrawal in humans. ( Foltin, RW; Haney, M; Hart, CL; Ward, AS, 2003)
"Maintenance treatment to prevent recurrences is recommended for chronic forms of major depressive disorder (MDD), but few studies have examined maintenance efficacy of antidepressants with chronic MDD."2.71Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression. ( Arnow, B; Banks, P; Borian, FE; Dunner, DL; Gelenberg, AJ; Hirschfeld, RM; Howland, R; Keitner, GI; Keller, MB; Klein, DN; Kocsis, JH; Kornstein, SG; Manber, R; Markowitz, JC; Miller, I; Munsaka, M; Rothbaum, B; Rush, AJ; Russell, JM; Thase, ME; Trivedi, MH; Zajecka, J, 2003)
"The management of the patient's withdrawal symptoms is described."1.31Pharmacokinetically induced benzodiazepine withdrawal. ( Ninan, PT, 2001)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's7 (53.85)18.2507
2000's6 (46.15)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ninan, PT1
Haney, M2
Hart, CL1
Ward, AS1
Foltin, RW1
Gelenberg, AJ1
Trivedi, MH1
Rush, AJ1
Thase, ME1
Howland, R1
Klein, DN1
Kornstein, SG1
Dunner, DL1
Markowitz, JC1
Hirschfeld, RM1
Keitner, GI1
Zajecka, J1
Kocsis, JH1
Russell, JM1
Miller, I1
Manber, R1
Arnow, B1
Rothbaum, B1
Munsaka, M1
Banks, P1
Borian, FE1
Keller, MB1
Tamam, L1
Ozpoyraz, N1
Mischoulon, D1
Opitz, G1
Kelly, K1
Fava, M1
Rosenbaum, JF1
Benazzi, F2
Lauber, C1
Markowitz, JS1
Kotlyar, M1
Golding, M1
Brewer, ER1
Carson, SW1
Scharf, MB1
McDannold, M1
Zaretsky, N1
Spinner, O1
Stover, R1
Berkowitz, DV1
Conrad, C1
Rajagopalan, M1
Little, J1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Wayne Warrior CAnnabis Research and Education: Naturalistic Observation and Harm Reduction[NCT05386862]215 participants (Anticipated)Interventional2022-05-25Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for nefazodone and Substance Withdrawal Syndrome

ArticleYear
Effects of smoked marijuana in healthy and HIV + marijuana smokers.
    Journal of clinical pharmacology, 2002, Volume: 42, Issue:S1

    Topics: Bupropion; Dronabinol; Eating; HIV Seropositivity; Humans; Marijuana Smoking; Piperazines; Substance

2002

Trials

3 trials available for nefazodone and Substance Withdrawal Syndrome

ArticleYear
Nefazodone decreases anxiety during marijuana withdrawal in humans.
    Psychopharmacology, 2003, Volume: 165, Issue:2

    Topics: Adult; Affect; Antidepressive Agents, Second-Generation; Arousal; Attention; Dose-Response Relations

2003
Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression.
    Biological psychiatry, 2003, Oct-15, Volume: 54, Issue:8

    Topics: Acute Disease; Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Chronic Disease; C

2003
Evaluation of sleep architecture and cyclic alternating pattern rates in depressed insomniac patients treated with nefazodone hydrochloride.
    American journal of therapeutics, 1999, Volume: 6, Issue:2

    Topics: Adult; Antidepressive Agents, Second-Generation; Depression; Female; Humans; Male; Periodicity; Pipe

1999

Other Studies

9 other studies available for nefazodone and Substance Withdrawal Syndrome

ArticleYear
Pharmacokinetically induced benzodiazepine withdrawal.
    Psychopharmacology bulletin, 2001,Autumn, Volume: 35, Issue:4

    Topics: Alprazolam; Anti-Anxiety Agents; Antidepressive Agents, Second-Generation; Cyclohexanols; Drug Inter

2001
Discontinuation symptoms associated with nefazodone.
    Journal of psychopharmacology (Oxford, England), 2003, Volume: 17, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Relations

2003
A preliminary open study of the tolerability and effectiveness of nefazodone in major depressive disorder: comparing patients who recently discontinued an SSRI with those on no recent antidepressant treatment.
    Depression and anxiety, 2004, Volume: 19, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Relations

2004
Dangerous interaction with nefazodone added to fluoxetine, desipramine, venlafaxine, valproate and clonazepam combination therapy.
    Journal of psychopharmacology (Oxford, England), 1997, Volume: 11, Issue:2

    Topics: Adult; Antidepressive Agents; Clonazepam; Cyclohexanols; Depressive Disorder; Desipramine; Drug Ther

1997
Nefazodone withdrawal symptoms.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1998, Volume: 43, Issue:2

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Humans; Male; Phobic Disorders

1998
Nefazodone withdrawal syndrome.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1999, Volume: 44, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Female; Humans; Piperazines; Substance Withdrawal S

1999
Re: Nefazodone withdrawal symptoms.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1999, Volume: 44, Issue:3

    Topics: Antidepressive Agents, Second-Generation; Drug Interactions; Drug Therapy, Combination; Humans; Pipe

1999
Possible nefazodone withdrawal syndrome.
    The American journal of psychiatry, 1999, Volume: 156, Issue:7

    Topics: Adult; Dizziness; Humans; Male; Nausea; Piperazines; Selective Serotonin Reuptake Inhibitors; Substa

1999
Discontinuation symptoms with nefazodone.
    The Australian and New Zealand journal of psychiatry, 1999, Volume: 33, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Dose-Response Relationship, Dr

1999