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nefazodone and Depressive Disorder, Major

nefazodone has been researched along with Depressive Disorder, Major in 42 studies

nefazodone: may be useful as an opiate adjunct

Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Research Excerpts

ExcerptRelevanceReference
"To evaluate the feasibility of screening and recruiting patients with major depression and congestive heart failure (CHF) in a tertiary care cardiology hospital and to obtain preliminary efficacy, tolerability, and safety data for nefazodone treatment of a major depressive episode in CHF patients."9.10An open-label study of nefazodone treatment of major depression in patients with congestive heart failure. ( Calderone, A; Frasure-Smith, N; Lafontaine, S; Laliberté, MA; Lespérance, F; Rouleau, JL; Talajic, M; White, M, 2003)
"To evaluate the feasibility of screening and recruiting patients with major depression and congestive heart failure (CHF) in a tertiary care cardiology hospital and to obtain preliminary efficacy, tolerability, and safety data for nefazodone treatment of a major depressive episode in CHF patients."5.10An open-label study of nefazodone treatment of major depression in patients with congestive heart failure. ( Calderone, A; Frasure-Smith, N; Lafontaine, S; Laliberté, MA; Lespérance, F; Rouleau, JL; Talajic, M; White, M, 2003)
" This double-blind study tested the efficacy of nefazodone versus placebo for the treatment of depression in actively drinking alcohol-dependent patients who were also participating in weekly group treatment for alcoholism."5.09Nefazodone treatment of major depression in alcohol-dependent patients: a double-blind, placebo-controlled trial. ( Blume, AW; Cowley, DS; Jaffe, C; Kingsley, E; Pages, KP; Ries, RK; Roy-Byrne, PP; Russo, JE, 2000)
"All patients suffered from major depressive disorder and had a score of at least 14 on the 17-item Hamilton Rating Scale (HAMD)."2.73Combination treatment for acute depression is superior only when psychotherapy is added to medication. ( Blom, MB; Dusseldorp, E; Haffmans, J; Hoencamp, E; Jonker, K; Spinhoven, P; van Dyck, R, 2007)
"Participants were 431 chronically depressed patients who received Cognitive Behavioral Analysis System of Psychotherapy (CBASP), alone (N=214) or in combination with nefazodone (N=217), as part of a randomized chronic depression study (Keller et al."2.71Patient's therapeutic skill acquisition and response to psychotherapy, alone or in combination with medication. ( Arnow, B; Blalock, JA; Blasey, C; Keller, MB; Klein, DN; Manber, R; Markowitz, JC; McCullough, JP; Riso, LP; Rothbaum, B; Rush, AJ; Thase, ME; Vivian, D, 2003)
"Maintenance treatment to prevent recurrences is recommended for chronic forms of major depressive disorder (MDD), but few studies have examined maintenance efficacy of antidepressants with chronic MDD."2.71Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression. ( Arnow, B; Banks, P; Borian, FE; Dunner, DL; Gelenberg, AJ; Hirschfeld, RM; Howland, R; Keitner, GI; Keller, MB; Klein, DN; Kocsis, JH; Kornstein, SG; Manber, R; Markowitz, JC; Miller, I; Munsaka, M; Rothbaum, B; Rush, AJ; Russell, JM; Thase, ME; Trivedi, MH; Zajecka, J, 2003)
"Major depressive disorder is associated with considerable morbidity, disability, and risk for suicide."2.71Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. ( Dunner, DL; Heim, CM; Keitner, G; Keller, MB; Klein, DN; Kornstein, S; McCullough, JP; Nemeroff, CB; Ninan, PT; Rothbaum, BO; Rush, AJ; Schatzberg, AF; Thase, ME; Weiss, PM, 2003)
"Metyrapone treatment was well tolerated without serious adverse effects."2.71Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial. ( Jahn, H; Kellner, M; Kiefer, F; Schick, M; Wiedemann, K; Yassouridis, A, 2004)
" The dosage of nefazodone was 100 to 600 mg/d; CBASP was provided twice weekly during weeks 1 through 4 and weekly thereafter."2.71Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not. ( Arnow, BA; Banks, PL; Blalock, JA; Borian, FE; Howland, R; Keller, MB; Klein, DN; Kocsis, JH; Kornstein, SG; Manber, R; Markowitz, JC; Miller, I; Ninan, PT; Rothbaum, BO; Rush, AJ; Schatzberg, AF; Thase, ME; Trivedi, MH, 2005)
"Nefazodone was efficacious in symptom alleviation in patients with comorbid anxiety and depression."2.71Mixed anxiety and depression in older adults: clinical characteristics and management. ( Cassidy, EL; Lauderdale, S; Sheikh, JI, 2005)
"Data for 996 patients with major depressive disorder (DSM-III-R criteria), who participated in a 12-week acute phase study with nefazodone, were subjected to a post hoc analysis of changes in symptom cluster scores."2.71Symptom clusters as predictors of late response to antidepressant treatment. ( Grannemann, BD; Mahadi, S; Morris, DW; Trivedi, MH, 2005)
" Assessments included Clinical Global Impression Scales, Hamilton Rating Scales for Depression and Anxiety, Montgomery-Asberg Depression Rating Scale and the Patient Global Assessment Scale, in addition to a review of reported adverse events, vital sign measurements, electrocardiograms and clinical laboratory tests."2.70A randomized, double-blind controlled comparison of nefazodone and paroxetine in the treatment of depression: safety, tolerability and efficacy in continuation phase treatment. ( Baldwin, DS; Hawley, CJ; Mellors, K, 2001)
"Patients with chronic forms of major depressive disorder were randomized to 12 weeks of nefazodone, Cognitive Behavioral Analysis System of Psychotherapy (CBASP), or combined nefazodone/CBASP."2.70Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination. ( Borian, FE; Crits-Christoph, P; Dunner, DL; Hirschfeld, RM; Keitner, G; Keller, MB; Klein, DN; Koran, LM; Kornstein, SG; Markowitz, JC; Miller, I; Nemeroff, CB; Ninan, PT; Rush, AJ; Schatzberg, AF; Thase, ME; Trivedi, MH, 2002)
"Major depressive disorder is one of the most common mental disorders in children and adolescents."2.53Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis. ( Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X, 2016)
"Nefazodone was well tolerated and no significant changes in sexual function were reported."1.31Three- to four-year follow-up to an open trial of nefazodone for combat-related posttraumatic stress disorder. ( Beckham, JC; Davidson, JR; Feldman, ME; Hertzberg, MA; Moore, SD, 2002)
" Serial HRV recordings revealed that both the mean resting heart rate and systolic blood pressure significantly decreased after 21 days of nefazodone treatment (average dosage 413 mg/day), whereas after 10 days (average dosage 270."1.31Autonomic neurocardiac function in patients with major depression and effects of antidepressive treatment with nefazodone. ( Agelink, MW; Klieser, E; Linka, T; Majewski, T; Postert, T; Rotterdam, S; Wurthmann, C, 2001)

Research

Studies (42)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (4.76)18.2507
2000's35 (83.33)29.6817
2010's5 (11.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Steidtmann, D1
Manber, R12
Blasey, C4
Markowitz, JC12
Klein, DN15
Rothbaum, BO6
Thase, ME15
Kocsis, JH7
Arnow, BA7
Cipriani, A1
Zhou, X1
Del Giovane, C1
Hetrick, SE1
Qin, B1
Whittington, C1
Coghill, D1
Zhang, Y1
Hazell, P1
Leucht, S1
Cuijpers, P1
Pu, J1
Cohen, D1
Ravindran, AV1
Liu, Y1
Michael, KD1
Yang, L1
Liu, L1
Xie, P1
Preskorn, SH1
Kraemer, HC1
Trivedi, MH8
Rush, AJ11
Gelenberg, AJ2
Keller, ME1
Leon, AC1
Arnow, B5
Maddux, RE1
Riso, LP4
Blalock, JA5
Keitner, GI2
Denton, WH1
Carmody, TJ1
Keller, MB9
Stulz, N1
Crits-Christoph, P2
Blom, MB3
Hoek, HW1
Spinhoven, P3
Hoencamp, E3
Judith Haffmans, PM1
van Dyck, R3
Hertzberg, MA1
Feldman, ME1
Beckham, JC1
Moore, SD1
Davidson, JR1
Amow, B1
Klein, D1
Korenstein, SG1
Dunner, DL5
Munsaka, M2
Borian, FE6
Keller, B1
Vivian, D3
McCullough, JP4
Rothbaum, B3
Argyropoulos, SV1
Hicks, JA1
Nash, JR1
Bell, CJ1
Rich, AS1
Nutt, DJ1
Wilson, SJ1
Howland, R2
Kornstein, SG4
Hirschfeld, RM2
Zajecka, J1
Russell, JM1
Miller, I3
Banks, P1
Nemeroff, CB2
Heim, CM1
Schatzberg, AF3
Ninan, PT3
Weiss, PM1
Kornstein, S1
Keitner, G3
Schwartz, JE1
Santiago, NJ1
Vocisano, C1
Castonguay, LG1
Miller, IW1
Lespérance, F1
Frasure-Smith, N1
Laliberté, MA1
White, M1
Lafontaine, S1
Calderone, A1
Talajic, M1
Rouleau, JL1
Tamam, L1
Ozpoyraz, N1
Mischoulon, D1
Opitz, G1
Kelly, K1
Fava, M2
Rosenbaum, JF1
Hernandez-Avila, CA1
Modesto-Lowe, V1
Feinn, R1
Kranzler, HR1
Koran, LM2
Jahn, H1
Schick, M1
Kiefer, F1
Kellner, M1
Yassouridis, A1
Wiedemann, K1
Almási, J1
Rihmer, Z1
Banks, PL1
Cassidy, EL1
Lauderdale, S1
Sheikh, JI1
Morris, DW1
Grannemann, BD1
Mahadi, S1
Clayton, AH1
Montejo, AL1
Constantino, MJ1
Papakostas, GI2
Hoffman, T1
Jonker, K2
Haffmans, PM1
Dusseldorp, E1
Haffmans, J1
Shelton, RC1
Sajatovic, M1
DiGiovanni, S1
Fuller, M1
Belton, J1
DeVega, E1
Marqua, S1
Liebling, D1
Roy-Byrne, PP1
Pages, KP1
Russo, JE1
Jaffe, C1
Blume, AW1
Kingsley, E1
Cowley, DS1
Ries, RK1
D'Mello, DA1
Meland, R1
Ransom, S1
Agelink, MW1
Majewski, T1
Wurthmann, C1
Postert, T1
Linka, T1
Rotterdam, S1
Klieser, E1
Sánchez-Lacay, JA1
Lewis-Fernández, R1
Goetz, D1
Blanco, C1
Salmán, E1
Davies, S1
Liebowitz, M1
Jerome, L1
Baldwin, DS1
Hawley, CJ1
Mellors, K1
Gillin, JC1
Smith-Vaniz, A1
Schnierow, B1
Rapaport, MH1
Kelsoe, J1
Raimo, E1
Marler, MR1
Goyette, LM1
Stein, MB1
Zisook, S1

Clinical Trials (8)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD) a Multicentre Open-label Randomized Controlled Trial Protocol[NCT05814640]Phase 1/Phase 2520 participants (Anticipated)Interventional2023-02-20Recruiting
Development and Evaluation of an Ecological Momentary Assessment (EMA) Baseline Screening System for Therapists Who Treat Youths With Depressive Symptoms[NCT04830527]60 participants (Actual)Interventional2020-11-24Terminated (stopped due to The study was terminated early due to the difficulty in recruiting cases during a pandemic period.)
Partnership in Medication Management (PIMM): The Effects of One-on-one Medication Training on Medication Adherence in Patients With Mood Disorders[NCT02285608]166 participants (Anticipated)Interventional2015-01-31Recruiting
Cognitive Behavioral Analysis System of Psychotherapy (CBASP) vs. Behavioral Activation (BA) in Persistently Depressed Treatment-resistant Inpatients: Efficacy, Moderators, and Mediators of Change[NCT04996433]396 participants (Anticipated)Interventional2021-12-01Recruiting
Assessing the Emotional and Physiological Response of Adults to Completing a Self-report Scale on Exposure to Childhood Maltreatment - Online Component[NCT06152549]500 participants (Anticipated)Observational2022-10-15Recruiting
Double-Blind, Placebo Controlled Trial of Metyrapone as Augmenting Agent in the Treatment of Major Depression[NCT00125554]Phase 263 participants Interventional1998-05-31Completed
Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.[NCT03491696]Phase 414 participants (Anticipated)Interventional2018-12-22Recruiting
Model for Early Prediction of Clinical Response in Patients With Major Depression Receiving Fluoxetine[NCT01075529]Phase 4140 participants (Actual)Interventional2007-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for nefazodone and Depressive Disorder, Major

ArticleYear
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
    Lancet (London, England), 2016, Aug-27, Volume: 388, Issue:10047

    Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Co

2016
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
    Lancet (London, England), 2016, Aug-27, Volume: 388, Issue:10047

    Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Co

2016
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
    Lancet (London, England), 2016, Aug-27, Volume: 388, Issue:10047

    Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Co

2016
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis.
    Lancet (London, England), 2016, Aug-27, Volume: 388, Issue:10047

    Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Co

2016
Correlation of subjective and objective sleep measurements at different stages of the treatment of depression.
    Psychiatry research, 2003, Sep-30, Volume: 120, Issue:2

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Double-Blind Method; El

2003
[Review of antidepressants from the TCAs to the third generation drugs].
    Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology, 2004, Volume: 6, Issue:4

    Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; B

2004
Major depressive disorder, antidepressants, and sexual dysfunction.
    The Journal of clinical psychiatry, 2006, Volume: 67 Suppl 6

    Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; B

2006
A meta-analysis of clinical trials comparing the serotonin (5HT)-2 receptor antagonists trazodone and nefazodone with selective serotonin reuptake inhibitors for the treatment of major depressive disorder.
    European psychiatry : the journal of the Association of European Psychiatrists, 2007, Volume: 22, Issue:7

    Topics: Depressive Disorder, Major; Humans; Piperazines; Selective Serotonin Reuptake Inhibitors; Serotonin

2007
Augmentation of antidepressants with atypical antipsychotics for treatment-resistant major depressive disorder.
    Acta psychiatrica Scandinavica, 2008, Volume: 117, Issue:4

    Topics: Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Benzodiazepines; Depressive Disorder, Maj

2008

Trials

29 trials available for nefazodone and Depressive Disorder, Major

ArticleYear
Detecting critical decision points in psychotherapy and psychotherapy + medication for chronic depression.
    Journal of consulting and clinical psychology, 2013, Volume: 81, Issue:5

    Topics: Adult; Antidepressive Agents; Chronic Disease; Cognitive Behavioral Therapy; Combined Modality Thera

2013
Patient preference as a moderator of outcome for chronic forms of major depressive disorder treated with nefazodone, cognitive behavioral analysis system of psychotherapy, or their combination.
    The Journal of clinical psychiatry, 2009, Volume: 70, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Chronic Disease; Cognitive Behavioral Therapy; Comb

2009
Select comorbid personality disorders and the treatment of chronic depression with nefazodone, targeted psychotherapy, or their combination.
    Journal of affective disorders, 2009, Volume: 117, Issue:3

    Topics: Adaptation, Psychological; Adult; Antidepressive Agents, Second-Generation; Chronic Disease; Cogniti

2009
Dyadic discord at baseline is associated with lack of remission in the acute treatment of chronic depression.
    Psychological medicine, 2010, Volume: 40, Issue:3

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Chronic Disease; Cognitive Behavi

2010
Differential effects of treatments for chronic depression: a latent growth model reanalysis.
    Journal of consulting and clinical psychology, 2010, Volume: 78, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Chronic Disease; Cognitive Behavioral Therapy; Comb

2010
Treatment of depression in patients from ethnic minority groups in the Netherlands.
    Transcultural psychiatry, 2010, Volume: 47, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Combined Modality Therapy; Cross-Cultural Compariso

2010
The effects of psychotherapy, nefazodone, and their combination on subjective assessment of disturbed sleep in chronic depression.
    Sleep, 2003, Mar-15, Volume: 26, Issue:2

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Chronic Disease; Combined Modalit

2003
Patient's therapeutic skill acquisition and response to psychotherapy, alone or in combination with medication.
    Psychological medicine, 2003, Volume: 33, Issue:4

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Chronic Disease; Cognitive Behavi

2003
Correlation of subjective and objective sleep measurements at different stages of the treatment of depression.
    Psychiatry research, 2003, Sep-30, Volume: 120, Issue:2

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Double-Blind Method; El

2003
Randomized, placebo-controlled trial of nefazodone maintenance treatment in preventing recurrence in chronic depression.
    Biological psychiatry, 2003, Oct-15, Volume: 54, Issue:8

    Topics: Acute Disease; Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Chronic Disease; C

2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Child; Child Abuse; Chronic Disea

2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Child; Child Abuse; Chronic Disea

2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Child; Child Abuse; Chronic Disea

2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Child; Child Abuse; Chronic Disea

2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Child; Child Abuse; Chronic Disea

2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Child; Child Abuse; Chronic Disea

2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Child; Child Abuse; Chronic Disea

2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Child; Child Abuse; Chronic Disea

2003
Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma.
    Proceedings of the National Academy of Sciences of the United States of America, 2003, Nov-25, Volume: 100, Issue:24

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Child; Child Abuse; Chronic Disea

2003
Therapeutic alliance in depression treatment: controlling for prior change and patient characteristics.
    Journal of consulting and clinical psychology, 2003, Volume: 71, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Combined Modality The

2003
Therapeutic reactance as a predictor of outcome in the treatment of chronic depression.
    Journal of consulting and clinical psychology, 2003, Volume: 71, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Cognitive Behavioral Therapy; Combined Modality The

2003
An open-label study of nefazodone treatment of major depression in patients with congestive heart failure.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2003, Volume: 48, Issue:10

    Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Diagnostic and St

2003
Nefazodone treatment of comorbid alcohol dependence and major depression.
    Alcoholism, clinical and experimental research, 2004, Volume: 28, Issue:3

    Topics: Adult; Alcoholism; Analysis of Variance; Chi-Square Distribution; Depressive Disorder, Major; Diagno

2004
Continuation treatment of chronic depression: a comparison of nefazodone, cognitive behavioral analysis system of psychotherapy, and their combination.
    Psychopharmacology bulletin, 2003, Volume: 37, Issue:4

    Topics: Adolescent; Adult; Aged; Antidepressive Agents, Second-Generation; Chronic Disease; Cognitive Behavi

2003
Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial.
    Archives of general psychiatry, 2004, Volume: 61, Issue:12

    Topics: Adrenocorticotropic Hormone; Adult; Antidepressive Agents; Cortodoxone; Dehydroepiandrosterone; Depr

2004
Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial.
    Archives of general psychiatry, 2004, Volume: 61, Issue:12

    Topics: Adrenocorticotropic Hormone; Adult; Antidepressive Agents; Cortodoxone; Dehydroepiandrosterone; Depr

2004
Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial.
    Archives of general psychiatry, 2004, Volume: 61, Issue:12

    Topics: Adrenocorticotropic Hormone; Adult; Antidepressive Agents; Cortodoxone; Dehydroepiandrosterone; Depr

2004
Metyrapone as additive treatment in major depression: a double-blind and placebo-controlled trial.
    Archives of general psychiatry, 2004, Volume: 61, Issue:12

    Topics: Adrenocorticotropic Hormone; Adult; Antidepressive Agents; Cortodoxone; Dehydroepiandrosterone; Depr

2004
Chronic depression: medication (nefazodone) or psychotherapy (CBASP) is effective when the other is not.
    Archives of general psychiatry, 2005, Volume: 62, Issue:5

    Topics: Adult; Antidepressive Agents, Second-Generation; Chronic Disease; Cognitive Behavioral Therapy; Cros

2005
Mixed anxiety and depression in older adults: clinical characteristics and management.
    Journal of geriatric psychiatry and neurology, 2005, Volume: 18, Issue:2

    Topics: Aged; Aging; Antidepressive Agents, Second-Generation; Anxiety Disorders; Comorbidity; Depressive Di

2005
Symptom clusters as predictors of late response to antidepressant treatment.
    The Journal of clinical psychiatry, 2005, Volume: 66, Issue:8

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Diagnostic and Statisti

2005
Dropouts versus completers among chronically depressed outpatients.
    Journal of affective disorders, 2007, Volume: 97, Issue:1-3

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Antidepressive Agents, Second-Generation; Anxiety Disorder

2007
Severity and duration of depression, not personality factors, predict short term outcome in the treatment of major depression.
    Journal of affective disorders, 2007, Volume: 104, Issue:1-3

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Combined Modality Therapy; Depressive Disorder

2007
Combination treatment for acute depression is superior only when psychotherapy is added to medication.
    Psychotherapy and psychosomatics, 2007, Volume: 76, Issue:5

    Topics: Acute Disease; Adult; Antidepressive Agents, Second-Generation; Combined Modality Therapy; Depressiv

2007
Nefazodone therapy in patients with treatment-resistant or treatment-intolerant depression and high psychiatric comorbidity.
    Clinical therapeutics, 1999, Volume: 21, Issue:4

    Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Comorbidity; Depressive Disorder, Major; Fema

1999
Nefazodone treatment of major depression in alcohol-dependent patients: a double-blind, placebo-controlled trial.
    Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:2

    Topics: Adolescent; Adult; Alcoholism; Antidepressive Agents, Second-Generation; Combined Modality Therapy;

2000
Open trial of nefazodone among Hispanics with major depression: efficacy, tolerability, and adherence issues.
    Depression and anxiety, 2001, Volume: 13, Issue:3

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Female; Hispanic or Lat

2001
A randomized, double-blind controlled comparison of nefazodone and paroxetine in the treatment of depression: safety, tolerability and efficacy in continuation phase treatment.
    Journal of psychopharmacology (Oxford, England), 2001, Volume: 15, Issue:3

    Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder, Major; Double-Blind Method; Female; Humans; Long

2001
An open-label, 12-week clinical and sleep EEG study of nefazodone in chronic combat-related posttraumatic stress disorder.
    The Journal of clinical psychiatry, 2001, Volume: 62, Issue:10

    Topics: Arousal; Combat Disorders; Depressive Disorder, Major; Dreams; Electroencephalography; Humans; Male;

2001
Does psychosocial functioning improve independent of depressive symptoms? A comparison of nefazodone, psychotherapy, and their combination.
    Biological psychiatry, 2002, Jan-15, Volume: 51, Issue:2

    Topics: Adult; Antidepressive Agents, Second-Generation; Chronic Disease; Cognitive Behavioral Therapy; Comb

2002

Other Studies

8 other studies available for nefazodone and Depressive Disorder, Major

ArticleYear
How multiple medication use evolves and the importance of therapeutic trials: the slippery slide.
    Journal of psychiatric practice, 2008, Volume: 14, Issue:3

    Topics: Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Anxiety Disorders; Asthma; Broncho

2008
Faster remission of chronic depression with combined psychotherapy and medication than with each therapy alone.
    Journal of consulting and clinical psychology, 2008, Volume: 76, Issue:3

    Topics: Adolescent; Adult; Aged; Antidepressive Agents; Anxiety Disorders; Chronic Disease; Cognitive Behavi

2008
Three- to four-year follow-up to an open trial of nefazodone for combat-related posttraumatic stress disorder.
    Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2002, Volume: 14, Issue:4

    Topics: Adult; Anger; Antidepressive Agents, Second-Generation; Chronic Disease; Clinical Trials as Topic; C

2002
Discontinuation symptoms associated with nefazodone.
    Journal of psychopharmacology (Oxford, England), 2003, Volume: 17, Issue:4

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Relations

2003
A preliminary open study of the tolerability and effectiveness of nefazodone in major depressive disorder: comparing patients who recently discontinued an SSRI with those on no recent antidepressant treatment.
    Depression and anxiety, 2004, Volume: 19, Issue:1

    Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Dose-Response Relations

2004
Nefazodone and hypotension: complication or coincidence.
    Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:2

    Topics: Adult; Antidepressive Agents, Second-Generation; Cohort Studies; Depressive Disorder, Major; Female;

1997
Autonomic neurocardiac function in patients with major depression and effects of antidepressive treatment with nefazodone.
    Journal of affective disorders, 2001, Volume: 62, Issue:3

    Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Blood Pressure; Case-Control Studies; Depress

2001
Bupropion and drug-induced parkinsonism.
    Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2001, Volume: 46, Issue:6

    Topics: Bupropion; Depressive Disorder, Major; Drug Interactions; Drug Therapy, Combination; Humans; Male; M

2001