Page last updated: 2024-10-31

nefazodone and Depression

nefazodone has been researched along with Depression in 15 studies

nefazodone: may be useful as an opiate adjunct

Depression: Depressive states usually of moderate intensity in contrast with MAJOR DEPRESSIVE DISORDER present in neurotic and psychotic disorders.

Research Excerpts

ExcerptRelevanceReference
"Nefazodone is a recently marketed compound with demonstrated efficacy in major depression."9.08An open-label trial of nefazodone in high comorbidity panic disorder. ( DeMartinis, NA; Rickels, K; Schweizer, E, 1996)
"Nefazodone has been widely used as an antidepressant, but it has not been tested for depression with anger attacks."7.71An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor binding. ( Bottonari, KA; Dougherty, DD; Fava, M; Fischman, AJ; Gresham, RL; Mischoulon, D; Sonawalla, SB, 2002)
" In particular, patients beginning therapy with fluoxetine are more likely to receive treatment regimens that meet minimum recommended guidelines for dosage and duration and are less likely to require treatment switching/augmentation than those receiving tricyclic antidepressants or other SSRIs as initial therapy."6.40Fluoxetine. A pharmacoeconomic review of its use in depression. ( Benfield, P; Wilde, MI, 1998)
"Nefazodone is a recently marketed compound with demonstrated efficacy in major depression."5.08An open-label trial of nefazodone in high comorbidity panic disorder. ( DeMartinis, NA; Rickels, K; Schweizer, E, 1996)
"Nefazodone has been widely used as an antidepressant, but it has not been tested for depression with anger attacks."3.71An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor binding. ( Bottonari, KA; Dougherty, DD; Fava, M; Fischman, AJ; Gresham, RL; Mischoulon, D; Sonawalla, SB, 2002)
" In particular, patients beginning therapy with fluoxetine are more likely to receive treatment regimens that meet minimum recommended guidelines for dosage and duration and are less likely to require treatment switching/augmentation than those receiving tricyclic antidepressants or other SSRIs as initial therapy."2.40Fluoxetine. A pharmacoeconomic review of its use in depression. ( Benfield, P; Wilde, MI, 1998)
"Nefazodone was administered for 14 to 28 weeks before the onset of symptoms."1.30Nefazodone-induced liver failure: report of three cases. ( Aranda-Michel, J; Balistreri, WF; Bejarano, PA; Ee, LC; Khan, CM; Koehler, A; Luxon, BA; Poulos, JE; Weber, FL, 1999)

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's11 (73.33)18.2507
2000's4 (26.67)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kelly, BD1
Mischoulon, D1
Dougherty, DD1
Bottonari, KA1
Gresham, RL1
Sonawalla, SB1
Fischman, AJ1
Fava, M1
Avila, A1
Cardona, X1
Martin-Baranera, M1
Maho, P1
Sastre, F1
Bello, J1
Dremencov, E1
Newman, ME1
Kinor, N1
Blatman-Jan, G1
Schindler, CJ1
Overstreet, DH1
Yadid, G1
DeMartinis, NA1
Schweizer, E1
Rickels, K1
Ketter, TA1
Callahan, AM1
Post, R1
Benazzi, F1
Gaffney, PN1
Schuckman, HA1
Beeson, MS1
Aranda-Michel, J1
Koehler, A1
Bejarano, PA1
Poulos, JE1
Luxon, BA1
Khan, CM1
Ee, LC1
Balistreri, WF1
Weber, FL1
Wilde, MI1
Benfield, P1
Schrader, GD1
Roberts-Thompson, IC1
Scharf, MB1
McDannold, M1
Zaretsky, N1
Spinner, O1
Stover, R1
Berkowitz, DV1
Conrad, C1

Reviews

1 review available for nefazodone and Depression

ArticleYear
Fluoxetine. A pharmacoeconomic review of its use in depression.
    PharmacoEconomics, 1998, Volume: 13, Issue:5 Pt 1

    Topics: Antidepressive Agents, Tricyclic; Depression; Fluoxetine; Health Care Costs; Humans; Piperazines; Qu

1998

Trials

3 trials available for nefazodone and Depression

ArticleYear
Does nefazodone improve both depression and Parkinson disease? A pilot randomized trial.
    Journal of clinical psychopharmacology, 2003, Volume: 23, Issue:5

    Topics: Aged; Analysis of Variance; Depression; Female; Humans; Male; Middle Aged; Parkinson Disease; Pilot

2003
An open-label trial of nefazodone in high comorbidity panic disorder.
    The Journal of clinical psychiatry, 1996, Volume: 57, Issue:6

    Topics: Adult; Antidepressive Agents, Second-Generation; Anxiety Disorders; Comorbidity; Depression; Depress

1996
Evaluation of sleep architecture and cyclic alternating pattern rates in depressed insomniac patients treated with nefazodone hydrochloride.
    American journal of therapeutics, 1999, Volume: 6, Issue:2

    Topics: Adult; Antidepressive Agents, Second-Generation; Depression; Female; Humans; Male; Periodicity; Pipe

1999

Other Studies

11 other studies available for nefazodone and Depression

ArticleYear
Do new-generation antidepressants work?
    Irish medical journal, 2008, Volume: 101, Issue:5

    Topics: Antidepressive Agents, Second-Generation; Cyclohexanols; Depression; Fluoxetine; Humans; Paroxetine;

2008
An open pilot study of nefazodone in depression with anger attacks: relationship between clinical response and receptor binding.
    Psychiatry research, 2002, Dec-30, Volume: 116, Issue:3

    Topics: Adult; Anger; Antidepressive Agents, Second-Generation; Binding Sites; Brain; Depression; Female; Hu

2002
Hyperfunctionality of serotonin-2C receptor-mediated inhibition of accumbal dopamine release in an animal model of depression is reversed by antidepressant treatment.
    Neuropharmacology, 2005, Volume: 48, Issue:1

    Topics: Analysis of Variance; Animals; Antidepressive Agents, Tricyclic; Depression; Desipramine; Disease Mo

2005
Nefazodone relief of alprazolam interdose dysphoria: a potential therapeutic benefit of 3A3/4 inhibition.
    The Journal of clinical psychiatry, 1996, Volume: 57, Issue:7

    Topics: Alprazolam; Antidepressive Agents, Second-Generation; Anxiety; Cytochrome P-450 Enzyme Inhibitors; D

1996
[Nefazodon (Nefadar)--a new dual serotoninergic antidepressant. Introductory press conference: "Nefazodone--new perspectives in antidepressive therapy." 25-26 April 1997].
    Fortschritte der Neurologie-Psychiatrie, 1997, Volume: 65, Issue:10 Suppl N

    Topics: Antidepressive Agents, Second-Generation; Depression; Humans; Piperazines; Triazoles

1997
Parkinson's disease worsened by nefazodone.
    International journal of geriatric psychiatry, 1997, Volume: 12, Issue:12

    Topics: Aged; Antidepressive Agents, Second-Generation; Depression; Humans; Male; Parkinson Disease; Parkins

1997
[Sleep-profile of a 72-year-old depressive female patient. Depression and sleep disorders. Significance--causes--treatment].
    Fortschritte der Neurologie-Psychiatrie, 1998, Volume: 66, Issue:5 Suppl De

    Topics: Aged; Antidepressive Agents, Second-Generation; Depression; Female; Humans; Piperazines; Sleep Initi

1998
[Depression and sleep disorders. Progress in antidepressive therapy with nefazodone].
    Der Nervenarzt, 1998, Volume: 69, Issue:6 Suppl Ei

    Topics: Antidepressive Agents, Second-Generation; Depression; Humans; Piperazines; Sleep Initiation and Main

1998
Nefazodone overdose.
    The Annals of pharmacotherapy, 1998, Volume: 32, Issue:11

    Topics: Adult; Antidepressive Agents, Second-Generation; Depression; Drug Overdose; Female; Humans; Piperazi

1998
Nefazodone-induced liver failure: report of three cases.
    Annals of internal medicine, 1999, Feb-16, Volume: 130, Issue:4 Pt 1

    Topics: Adolescent; Antidepressive Agents, Second-Generation; Depression; Female; Humans; Liver; Liver Failu

1999
Adverse effect of nefazodone: hepatitis.
    The Medical journal of Australia, 1999, May-03, Volume: 170, Issue:9

    Topics: Adult; Antidepressive Agents, Second-Generation; Chemical and Drug Induced Liver Injury; Depression;

1999