necrostatin-5 has been researched along with Myocardial-Infarction* in 1 studies
1 other study(ies) available for necrostatin-5 and Myocardial-Infarction
| Article | Year |
|---|---|
Study of cardioprotective effects of necroptosis inhibitors on isolated rat heart subjected to global ischemia-reperfusion.
The cardioprotective effects of necroptosis inhibitors necrostatin-1 and necrostatin-5 were studied on the isolated heart model in rats. Intraperitoneal injection of necrostatin-1 (1.65 mg/kg) or necrostatin-5 (2.46 mg/kg) 60 min before reperfusion of the isolated heart reduced the infarction zone caused by 30-min global ischemia and 120-min reperfusion. Intracoronary injection of necrostatin-1 (44.5 μmol/liter) caused an increase of left-ventricular systolic pressure, that is produced a positive inotropic effect, but did not reduce the infarction zone. Topics: Animals; Apoptosis; Blood Flow Velocity; Blood Pressure; Cardiotonic Agents; Heart; Heart Rate; Heterocyclic Compounds, 3-Ring; Imidazoles; Indoles; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitriles; Rats; Rats, Wistar; Ventricular Function, Left | 2013 |