nattokinase has been researched along with Intracranial-Hemorrhages* in 1 studies
1 other study(ies) available for nattokinase and Intracranial-Hemorrhages
| Article | Year |
|---|---|
Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds.
Nattokinase is used as a health-promoting medicine for preventing thrombosis due to its fibrinolytic activity. Cerebral microbleed is remnant of blood extravasations from the damaged vessels related to cerebral microangiopathies. We report a patient, having used aspirin for secondary stroke prevention, who had an acute cerebellar hemorrhage after taking nattokinase 400 mg daily for 7 consecutive days. In addition to the hemorrhagic lesion, multiple microbleeds were demonstrated on brain MR images. We suggest that nattokinase may increase risk of intracerebral hemorrhage in patients who have bleeding-prone cerebral microangiopathy and are receiving other antithrombotic agent at the same time. Topics: Aspirin; Diffusion Magnetic Resonance Imaging; Female; Fibrinolytic Agents; Herb-Drug Interactions; Humans; Intracranial Hemorrhages; Ischemic Attack, Transient; Middle Aged; Plant Extracts; Platelet Aggregation Inhibitors; Self Medication; Stroke; Subtilisins; Thrombosis; Tomography, X-Ray Computed | 2008 |