natriuretic-peptide--c-type and Vascular-Diseases

C-type natriuretic peptide (CNP) is a member of Natriuretic peptides family which is synthesized and secreted by vascular endothelial cells. CNP can bind with specific G-protein coupling receptor -natriuretic peptide receptor-B (NPR-B) and elevate cellular cGMP level by activating guanylate cyclase. CNP regulates homeostasis of circulating system in an autocrine/paracrine manner. Vascular system, especially endothelium, is rich in CNP and its receptor. CNP exerts natriuretic and natriuretic effect and regulates vessel tone, inhibits migration and proliferation of vascular smooth muscle cell. CNP is tightly correlated with injured vascular diseases such as hypertension, atherosclerosis, thrombogenesis, restenosis and vascular calcification.

Topics: Animals; Humans; Muscle, Smooth, Vascular; Natriuretic Peptide, C-Type; Vascular Calcification; Vascular Diseases

Increased arterial compliance (COMPart) has recently been described in patients with cirrhosis, particularly in advanced disease. The aim of the present study was to relate COMPart with arterial levels of the circulating natriuretic peptides: atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP), both of which are vasodilators.. Thirty-one patients with cirrhosis, 14 non-cirrhotic patients with circulatory disturbances of the ischaemic and hypertensive type, and 10 healthy controls were investigated during a haemodynamic examination.. The patients with cirrhosis showed the well-known hyperdynamic circulation with elevated cardiac output, low arterial blood pressure, and reduced systemic vascular resistance. COMPart in the patients with cirrhosis (1.30 mL/mmHg) was significantly (P < 0.01) increased compared to that of non-cirrhotic patients (0.99 mL/mmHg) and controls (1.01 mL/mmHg). In the patients with cirrhosis, a significant inverse correlation was found between CNP and COMPart (r = -0.42, P < 0.01), but not between CNP and systemic vascular resistance (r = 0.31, P = 0.08). In the non-cirrhotic patients, CNP had a significant inverse correlation to COMPart (r = -0.68, P < 0.01) and a direct correlation to systemic vascular resistance (r = 0.62, P < 0.02). ANP was not significantly related to COMPart nor to systemic vascular resistance in any of the groups.. The finding of an inverse relation between CNP and COMPart may suggest that a compensatory down-regulation of CNP occurs in patients with cirrhosis and other types of circulatory disorders when vasodilation persists. Regulation of large and small arteries by CNP may be different in cirrhosis. Arterial ANP is not related to properties of the large or small arteries.

Topics: Adult; Aged; Arteries; Atrial Natriuretic Factor; Dilatation, Pathologic; Female; Hemodynamics; Humans; Liver Cirrhosis; Male; Middle Aged; Natriuretic Peptide, C-Type; Vascular Diseases