natriuretic-peptide--c-type and ST-Elevation-Myocardial-Infarction

To determine the predictive value of pro-C-type natriuretic peptide (pro-CNP) measurement in plasma sampled on admission from patients presenting with ST-elevation myocardial infarction (STEMI).. Prospective cohort study.. Two University Hospitals in Denmark.. 1760 consecutive patients (470 females and 1290 males) with confirmed STEMI.. The main outcome was all-cause mortality at 1 year after presentation and the primary measure was pro-CNP concentration in plasma at admission in all patients and longitudinal measurements in a consecutive subgroup of 287 patients. A reference population (n=688) defined cut-off values of increased pro-CNP concentrations.. In female but not male patients presenting with STEMI, high concentrations of pro-CNP (≥median) at admission independently indicate a higher risk of all-cause mortality. The findings are remarkably specific for female patients, suggesting a different vascular phenotype beyond traditional measures of coronary artery flow compared with male patients.

Topics: Biomarkers; Female; Humans; Male; Natriuretic Peptide, Brain; Natriuretic Peptide, C-Type; Prognosis; Prospective Studies; ST Elevation Myocardial Infarction