natriuretic-peptide--brain and Teratoma

In sacrococcygeal teratoma, the presence of high-output cardiac failure resulting from arteriovenous shunting through the large tumor has been associated with an adverse outcome. The objective of this study was to determine whether the tumor size and cardiac biomarkers in cord blood can predict neonatal survival in sacrococcygeal teratoma.. The tumor volume index and cord blood biomarkers for heart failure can be promising prognostic markers for neonatal survival in sacrococcygeal teratoma.

Topics: Adult; Biomarkers; Cohort Studies; Female; Fetal Blood; Humans; Infant, Newborn; Male; Natriuretic Peptide, Brain; Peptide Fragments; Perinatal Death; Predictive Value of Tests; Pregnancy; Sacrococcygeal Region; Sensitivity and Specificity; Survival Analysis; Teratoma; Troponin T; Tumor Burden; Ultrasonography, Prenatal; Young Adult

Bezold-Jarisch reflex (BJR) occurs when the cardioinhibitory receptors in the walls of ventricles are activated by various stimuli, with typical features of bradycardia, vasorelaxation, and hypotension. This reflex usually happens in parturient intrathecal anesthesia, as a result of decreased venous return by compression of inferior vena cava, but it is only rarely reported during general anesthesia.. Severe bradycardia and hypotension, indicating BJR, occurred during the induction of general anesthesia in a 3-month-old female child with giant intra-abdominal teratoma.. A giant intra-abdominal teratoma was detected by computed tomography scanning. The decreased left ventricular ejection faction along with increased troponin I and N-terminal pro-B-type natriuretic peptide indicated a preoperative mild cardiac dysfunction. BJR was diagnosed on the basis of the severe bradycardia and hypotension observed during the induction of general anesthesia, INTERVENTIONS:: Atropine failed to increase heart rate. Cardiopulmonary resuscitation was initiated immediately and epinephrine was injected intravenously because of sudden circulatory collapse. Soon after the return of spontaneous circulation, a central venous line was placed and invasive blood pressure was monitored. Vital signs and homeostasis were kept stable during teratoma resection.. The child was extubated after emergence from anesthesia in the operating room. Eleven days later, she had recovered without complications and was discharged.. General anesthesia should be induced with great care in patients with giant intra-abdominal masses, and the patient should be kept in the left-lateral table tilt position before induction.

Topics: Abdominal Neoplasms; Bradycardia; Cardiopulmonary Resuscitation; Dissection; Female; Humans; Hypotension; Infant; Natriuretic Peptide, Brain; Peptide Fragments; Reflex, Abnormal; Stroke Volume; Teratoma; Tomography, X-Ray Computed; Treatment Outcome; Troponin I; Tumor Burden; Vasodilation; Ventricular Dysfunction, Left

We assessed the temporal transcriptional activity profiles of the genes for type-B natriuretic factor, BNF, the isoform ANF, and other cardiac muscle proteins in differentiating cultures derived from multipotential mouse cell lines. P19 embryonal carcinoma cells and D3 embryonic stem cells were induced for in vitro cardiac myogenesis; RNA was isolated at regular intervals throughout the differentiation programs, and mRNAs were detected by reverse transcriptase mediated polymerase chain reactions. The transcriptional activation profiles of the ANF and BNF gene were similar, but there were quantitative differences that were best assayed by use of competitive internal DNA standards. The levels of induced BNF transcripts were highest in the P19 developmental system reaching approximately 10% of adult mouse ventricular muscle levels; those for ANF were lower, but also readily detected. The cell lines may be used to define the regulatory control elements for natriuretic factor gene expression, in stably transfected cell lines, during cardiac muscle growth.

Topics: Animals; Atrial Natriuretic Factor; Base Sequence; Cell Line; DNA Primers; DNA, Complementary; Gene Expression Regulation; Growth Inhibitors; Heart; Interleukin-6; Introns; Leukemia Inhibitory Factor; Lymphokines; Mice; Molecular Sequence Data; Myocardium; Natriuretic Peptide, Brain; Polymerase Chain Reaction; Recombinant Proteins; RNA, Messenger; Stem Cells; Teratoma; Transcription, Genetic; Transfection; Tumor Cells, Cultured