natriuretic-peptide--brain and Spherocytosis--Hereditary

Vascular complications, including pulmonary hypertension (PH), have been reported to occur following splenectomy for various disorders,including hereditary spherocytosis (HS). We performed a prospective cross-sectional study of 36 adults with HS (78% with prior splenectomy)utilizing echocardiography to estimate tricuspid regurgitant jet velocity (TRV) as well as measurement of N-terminal pro-B-type natriuretic peptide (NT-proBNP) to screen for PH. No participant with HS hada significantly elevated TRV or NT-proBNP level, despite a median 25-year interval since splenectomy (95% confidence interval for point prevalence 0, 0.097). Although our study was limited by a small sample size, it appears that persons with HS, following splenectomy, appear unlikely to be at significantly increased risk of developing PH to the degree reported for thalassemia and sickle cell disease

Topics: Adult; Aged; Aged, 80 and over; Cross-Sectional Studies; Early Diagnosis; Female; Humans; Hypertension, Pulmonary; Male; Middle Aged; Natriuretic Peptide, Brain; Postoperative Complications; Prevalence; Prospective Studies; Protein Precursors; Risk Factors; Spherocytosis, Hereditary; Splenectomy; Texas; Tricuspid Valve; Ultrasonography; Young Adult