natriuretic-peptide--brain and Periodontitis

N-terminal-pro-brain natriuretic peptide (NT-proBNP) is expressed during inflammation and considered to be a biomarker of cardiovascular disease (CVD). In the last decade, evidence has suggested that periodontitis is associated with CVD. However, little is known of the potential role of this peptide in periodontal disease. The aims of this study were to examine whether the levels of NT-proBNP in serum are increased in periodontal disease and if there is a relationship to severity of periodontitis.. A case-control study was carried out, in which serum samples were collected from 40 patients with periodontitis and from 40 nonperiodontitis individuals. Full periodontal examination was performed in all subjects. Demographic information, and clinical and history of certain diseases were also recorded. Determinations of serum NT-proBNP and high-sensitivity C-reactive protein concentrations were carried out in an independent laboratory.. The levels of NT-proBNP in serum were significantly higher in patients with periodontitis compared with controls (87.9 pg/mL vs 29.9 pg/mL, P < .0001). In addition, as periodontal disease progressed, the levels of NT-proBNP increased. Multivariable regression analysis showed that the periodontal inflamed surface area, a measure of periodontal inflammation and disease activity, was the only periodontal parameter significantly associated with elevated concentrations of NT-proBNP in serum (R. In periodontitis, increased serum NT-proBNP levels are observed in comparison with individuals without periodontitis. Moreover, the greater the degree of periodontal destruction, the higher the levels of NT-proBNP in serum.

Topics: Adult; Biomarkers; C-Reactive Protein; Case-Control Studies; Comorbidity; Female; Humans; Male; Natriuretic Peptide, Brain; Periodontitis

Although periodontitis is a risk factor for cardiovascular disease (CVD), the influence of periodontitis on Marfan syndrome (MFS) with CVD is unclear. The aim of this study was to assess the relationship between periodontal bacterial burden and MSF with CVD.. The subjects were patients with MFS with CVD (n = 47); age and gender matched non-MFS CVD patients (n = 48) were employed as controls. Full-mouth clinical measurements, including number of teeth, probing of pocket depth (PD), bleeding on probing (BOP) and community periodontal index (CPI) were recorded. We also evaluated the existence of three periodontal pathogens, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Prevotella intermedia using polymerase chain reaction assays. Serum antibody titers against the pathogens were also measured. We revealed that MFS with CVD patients had periodontitis more frequently than the age and gender matched non-MFS CVD control subjects. MFS with CVD patients had significantly severer periodontitis, fewer remaining teeth and deeper PD compared to the non-MFS CVD controls. Furthermore, the serum antibody titer level against Prevotella intermedia was significantly lower in MFS plus CVD patients compared to the non-MFS CVD patients.. Periodontitis may influence the pathophysiology of cardiovascular complications in MFS patients. A specific periodontal pathogen might be a crucial therapeutic target to prevent CVD development.

Topics: Adult; Antibodies, Bacterial; Bacteroidaceae Infections; C-Reactive Protein; Cardiovascular Diseases; Female; Humans; Male; Marfan Syndrome; Natriuretic Peptide, Brain; Periodontitis; Prevotella intermedia