natriuretic-peptide--brain and Pancreatitis

Topics: Acute Disease; Adult; Aged; Aged, 80 and over; Amylases; Biomarkers; C-Reactive Protein; Cardiomyopathies; Creatine Kinase; Diagnosis, Differential; Female; Humans; Lipase; Male; Middle Aged; Natriuretic Peptide, Brain; Pancreatitis; Peptide Fragments; Prospective Studies; Severity of Illness Index; Time Factors; Troponin T

The prevalence and clinical importance of cardiac abnormalities in dogs with acute pancreatitis (AP) is unknown.. Twelve dogs with AP and 60 archived serum samples from dogs with suspected AP.. Two-phase study.. Analysis of archived serum samples from dogs with clinical signs of AP and high Spec cPL concentrations. High sensitivity troponin I (TnIH) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations were measured in achieved serum samples.. Prospective observational study. Dogs with AP underwent echocardiography and Holter monitoring. Serum cardiac troponin I (cTnI) and plasma NT-proBNP concentrations were measured. Previously described disease severity indices were calculated for each dog.. Phase I: 41 of 60 dogs suspected of having AP had abnormally high TnIH concentrations and 13 of 60 had abnormally high serum NT-proBNP concentrations. Higher TnIH concentrations were observed in dogs with Spec cPL concentration >2000 μg/L as compared to those with concentrations of 1000-2000 μg/L.. 11 of 12 dogs diagnosed with pancreatitis had abnormal cTnI concentrations (median: 0.384 ng/mL, range: 0.041-2.966 ng/mL, RI: ≤0.06 ng/mL) and 7 of 12 dogs had plasma NT-proBNP concentrations above the reference interval (median: 971 pmol/L, range: 250-2215 pmol/L, RI: ≤900 pmol/L). Supraventricular and ventricular ectopic beats occurred in 3 dogs. Echocardiographic abnormalities were detected in 5 dogs. Cardiovascular variables were not associated with indices of disease severity.. Myocardial injury is common in dogs with AP, but clinical consequences appeared to be uncommon in our small cohort. Cardiac biomarkers should be interpreted with caution in dogs with AP.

Topics: Acute Disease; Animals; Biomarkers; Cardiovascular Abnormalities; Dog Diseases; Dogs; Natriuretic Peptide, Brain; Pancreatitis; Peptide Fragments; Troponin I

Acute pancreatitis (AP) is a systemic disease with a rising incidence. Cardiac dysfunction may occur as an early complication of AP. B type natriuretic factor (BNP) is a diagnostic and prognostic indicator of cardiac disorders. Therefore, in this study we aimed to assess the relationship between serum BNP concentrations and severity of AP.. Patients with AP who were admitted to gastroenterology clinic of our center, were included in this study. BNP measurements were performed twice, once on admission to the hospital and another after clinical and laboratory remission of the disease. All patients underwent echocardiography, abdominal ultrasonography and/or computed tomography chest X-ray and routine biochemical assays. Disease severity was determined by Ranson, Balthazar and Glasgow scoring systems.. A total of 55 patients with AP (33 male, 60%) were enrolled in the study. Causes of AP were biliary in 32 patients (58%), alcoholic in 10 (18%), idiopathic in 8 (15%), hyperlipidemic in 4 (7%) and ERCP related in one patient (2%), respectively. Serum BNP levels in first 2 days of admission and after the clinical and laboratory remission of disease were 444 ± 295.9 and 124 ± 109.5 pg/ml, respectively (p<0.001). Increased serum BNP levels were positively correlated with severity of the disease (p<0.001). We could not find a difference between serum BNPe levels of edematous and necrotizing patients (P = 0.683).. Increased serum BNP levels might be a plausible indicator of severity of AP during the course of the disease.

Topics: Adolescent; Adult; Female; Humans; Linear Models; Male; Middle Aged; Natriuretic Peptide, Brain; Pancreatitis; Pancreatitis, Acute Necrotizing; Prognosis; ROC Curve; Young Adult