natriuretic-peptide--brain and Leukemia--Biphenotypic--Acute

The main strategy for minimizing anthracycline cardiotoxicity is early detection of high-risk patients.. To investigate the role of cardiac biomarkers; cardiac troponin T (cTnT) and N-terminal probrain natriuretic peptide (NT-pro-BNP), and tissue Doppler imaging (TDI), as early predictors of chronic cardiotoxicity in survivors of acute leukemia.. We carried a retrospective study on 50 asymptomatic survivors of acute leukemia who received anthracycline in their treatment protocols. All patients underwent blood sampling to determine the levels of NT-pro-BNP and cTnT along with conventional echocardiography and TDI.. None had abnormal cTnT levels. About 20% had abnormal NT-pro-BNP levels. Diastolic dysfunction of the left ventricle was the most significant in conventional echocardiography. TDI was superior as it detected myocardial affection in 10% more than echo. TDI demonstrated global myocardial damage with significant aberrations in peak myocardial velocities and ratios.. NT-pro-BNP can be used as a sensitive cardiac biomarker in monitoring of anthracycline-induced cardiotoxicity. Follow up is essential to validate the role of NT-pro-BNP as an early marker for late onset anthracycline-induced cardiotoxicity. Tissue Doppler is marvelous as it could detect early cardiac dysfunction even in those with normal study by conventional echocardiography.

Topics: Adolescent; Anthracyclines; Antibiotics, Antineoplastic; Biomarkers; Cardiotoxins; Child; Child, Preschool; Early Diagnosis; Echocardiography, Doppler; Female; Heart; Humans; Leukemia, Biphenotypic, Acute; Male; Natriuretic Peptide, Brain; Peptide Fragments; Retrospective Studies; Survivors; Troponin T; Ventricular Dysfunction, Left