natriuretic-peptide--brain and Infant--Newborn--Diseases

The aim of the study was to assess myocardial damage in infants due to perinatal hypoxia.. The findings of 29 infants with perinatal hypoxia and 20 healthy infants were compared. Blood gas analysis, serum lactate, cardiac troponin I (cTnI), troponin T (cTnT), creatine kinase-MB (CK-MB) and B-type natriuretic peptide (BNP) were evaluated. Echocardiography together with tissue Doppler imaging was performed.. cTnT, CK-MB and BNP were higher in patients at the first day. There were positive correlations between the left ventricular (LV) myocardial performance index (MPI) and cTnT at first day and also at first month. LV ejection fraction and fractional shortening were lower at first day and at first month in patients. Myocardial systolic (Sm) and diastolic (Em and Am) velocities at all segments were lower at first day, and interventricular septum Sm, LV Sm, LV Em, right ventricular Em and LV Am were still lower at first month in patients. Isovolumic relaxation time at all segments together with LV MPI was higher at first day, ejection time values were lower and MPI values were higher at all segments at first month in patients.. These findings demonstrated that the signs of myocardial damage due to perinatal hypoxia still present at first month.

Topics: Asphyxia Neonatorum; Case-Control Studies; Echocardiography; Heart Diseases; Humans; Hypoxia; Infant, Newborn; Infant, Newborn, Diseases; Myocardium; Natriuretic Peptide, Brain; Time Factors; Troponin I; Troponin T; Ventricular Dysfunction, Left; Ventricular Function, Left

The aim of this study is to better characterize the time courses of BNP levels throughout the first days of life in larger populations of neonate and infant with or without congenital heart diseases (CHD) in order to increase the diagnostic accuracy of BNP assay in pediatric patients with CHD.. BNP was measured by an automated platform (Triage BNP reagents, ACCESS Immunoassay Systems, Beckman Coulter, Inc., Fullerton, CA 92835) in 218 neonates and infants with different CHD; 222 healthy children, matched for age, served as controls.. BNP values were significantly higher (P<0.001) in the whole group of CHD patients (median 1029.8 ng/L, range 25-20,152 ng/L) than in controls (median 149.5 ng/L, range 9-866 ng/L). A different trend between BNP values and age was observed in healthy subjects and CHD patients. After an initial increase within the first 4 days of life, BNP values in CHD patients tend to stabilize to high values in the following days. On the contrary, in control subjects a peak of BNP levels was observed in the second or third day, followed by a progressive decrease. Therefore, the diagnostic accuracy of BNP assay, calculated in the samples collected in the first four days of life (AUC of ROC analysis 0.86, 95% CI 0.83-0.90) was significantly lower (P<0.0001) compared to samples collected from 5 days to 30 days of life (AUC 0.97, 95% CI 0.95-0.99). Optimal cut-off values for BNP assay, as calculated by ROC analysis, were also age-dependent (cutoff for the first 4 days of life: 363.5 ng/L; cutoff values from 5 to 30 days of life: 109.5 ng/L).. Our study demonstrates that differences in time-courses of BNP values between newborns with and without CHD throughout the first days of life clearly affect the diagnostic accuracy of BNP assay. Indeed, the diagnostic accuracy of BNP assay in discriminating between healthy newborns and CHD patients progressively increases after the 4th day of life. As a result, also cutoff values of BNP assay greatly change throughout the first days of life. However, decision values of BNP assay are strongly method-dependent, consequently clinicians should give great care to compare results obtained by different laboratories, especially when different methods are used.

Topics: Area Under Curve; Case-Control Studies; Heart Defects, Congenital; Humans; Infant, Newborn; Infant, Newborn, Diseases; Natriuretic Peptide, Brain

Antenatal stress, maturation and other foetal conditions affect the postnatal cardiovascular function. Atrial- (ANP) and brain-type natriuretic peptide (BNP) play important roles in regulating extracellular fluid volume and blood pressure, which may surrogate the foetal cardiovascular condition. The aim of this study was to investigate the dependence of serum ANP and BNP at birth on antenatal variables in high-risk infants.. Plasma ANP and BNP levels in the umbilical cord blood were compared with antenatal clinical information in 280 infants.. High levels of ANP and BNP were associated with multiple pregnancy, antenatal magnesium sulphate and foetal distress. Caesarean section (CS) was paradoxically associated with low ANP and high BNP; low ANP was related with CS before labour whereas high BNP was related with CS after the commencement of labour. High BNP levels further correlated with younger gestational age and intrauteral growth restriction. With regard to short-term postnatal variables, high BNP levels were associated with low Apgar scores and respiratory failure whereas high ANP only correlated with the latter.. High natriuretic peptide levels were associated with prematurity at birth, uteral contraction and antenatal stress: cord blood ANP and BNP may be a useful surrogate marker for hidden antenatal stress.

Topics: Analysis of Variance; Atrial Natriuretic Factor; Biomarkers; Cardiovascular Physiological Phenomena; Cesarean Section; Female; Fetal Development; Gestational Age; Humans; Infant, Newborn; Infant, Newborn, Diseases; Infant, Premature; Male; Natriuretic Peptide, Brain; Risk Factors; Stress, Physiological