natriuretic-peptide--brain and Convalescence

Brain natriuretic peptide (BNP) secretion increases after myocardial infarction (MI); its plasma level may reflect the degree of left ventricular dysfunction. This study examines how aerobic exercise therapy for MI influences BNP secretion. Subjects included 70 patients (mean age, 62.0+/-11.3 years) who were divided into four groups: (1) 20 patients with an anterior MI and exercise training; (2) 20 patients with an anterior MI and no exercise training; (3) 15 patients with an inferior MI and exercise training; and (4) 15 patients with an inferior MI and no exercise training. The training groups performed aerobic exercise 3 times a week for 2 months. Exercise intensity was defined as a heart rate of anaerobic threshold (AT), derived from the treadmill cardiopulmonary exercise testing at 1 month after the onset of MI. The subjects underwent cardiopulmonary exercise testing again at 3 months after the onset of MI. To measure BNP, blood samples were obtained in the resting state and immediately after the peak exercise. AT and peak oxygen uptake increased in the training group with anterior MI and in both the training and nontraining groups with inferior MI. Significant serial change in plasma BNP level was not observed in the inferior MI groups. Plasma BNP level decreased longitudinally only in the nontraining anterior MI group. It was concluded that exercise training in patients with an anterior MI could delay the recovery of left ventricular function, but will increase exercise tolerance.

Topics: Aged; Convalescence; Exercise; Exercise Test; Exercise Tolerance; Humans; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Physical Therapy Modalities; Quality of Life; Rest; Ventricular Dysfunction, Left

Topics: Aftercare; Betacoronavirus; Comorbidity; Convalescence; Coronavirus Infections; COVID-19; Echocardiography; Electrocardiography; General Practice; Heart Diseases; Humans; Magnetic Resonance Imaging, Cine; Natriuretic Peptide, Brain; Pandemics; Patient Acuity; Peptide Fragments; Pneumonia, Viral; Recovery of Function; SARS-CoV-2; Symptom Assessment; Troponin

Topics: Acute Disease; Convalescence; Coronary Aneurysm; Echocardiography, Doppler; Female; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Infant; Mucocutaneous Lymph Node Syndrome; Natriuretic Peptide, Brain; Plasma Exchange

The hepatocyte growth factor (HGF) is a multifunctional cytokine with cardioprotective properties and potent myogenic activity for vascular endothelium. In patients after acute myocardial infarction, exercise training has the beneficial effects on cardiovascular adaptations. We hypothesized that exercise induces HGF production in those patients. If this hypothesis is correct, HGF production may be associated with clinical parameters of cardiovascular function.. In 20 patients after acute myocardial infarction, HGF levels in the pulmonary artery (HGF(PA)) and aorta (HGF(Ao)) were determined at rest and during supine submaximal exercise, with cardiac output (CO) measured by catheterization. Exercise-induced HGF production was calculated by using the following equation: [(HGF(PA)-HGF(Ao))xCO during exercise]-[(HGF(PA)-HGF(Ao))xCO at rest]. On a separate day, peak oxygen uptake (VO2) was determined during a symptom-limited upright cardiopulmonary exercise test. Exercise increased HGF production (from 1.6 +/- 3.0 to 9.0 +/- 6.3 microg/ml, p<0.001). Exercise-induced HGF production was inversely related to peak VO2 (r=-0.664, p<0.01) and positively related to levels of brain natriuretic peptide (BNP), a biochemical marker for post-infarction ventricular remodeling (r=0.686, p<0.01).. Exercise significantly increases HGF production. This phenomenon may play an important role in post-infarction patients, particularly with reduced exercise tolerance and elevated BNP levels.

Topics: Aged; Convalescence; Exercise; Exercise Test; Exercise Tolerance; Female; Heart Rate; Hepatocyte Growth Factor; Humans; Male; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Oxygen Consumption; Supine Position; Ventricular Remodeling

Circulating levels of B-type natriuretic peptide (BNP), a cardiac hormone, reflect the severity of cardiac dysfunction. Because the plasma BNP level changes dramatically during the period after the onset of acute myocardial infarction (AMI), identification of a suitable sampling time is problematic. There have been several reports indicating that the plasma BNP level obtained in the acute phase of AMI can be used as a prognostic marker. We examined whether the plasma BNP level measured 3 to 4 weeks after the onset of AMI represents a reliable prognostic marker for patients with AMI.. We analyzed 145 consecutive patients with AMI. Plasma BNP levels were measured during the 3 to 4 weeks after onset of AMI. Of those patients, 23 experienced fatal cardiac events during this study. The mean follow-up period was 58.6 months. Log BNP, left ventricular end-diastolic pressure, and pulmonary vascular resistance were all significantly higher in the cardiac death group, and there were more men and more patients with a history of heart failure in the cardiac death group. A Cox proportional hazards model analysis showed that log BNP was an independent predictor of cardiac death. The survival rate was significantly higher in patients with log BNP <2.26 (180 pg/mL) than in those with log BNP > or =2.26.. The plasma BNP level obtained 3 to 4 weeks after the onset of AMI can be used as an independent predictor of cardiac death in patients with AMI.

Topics: Adult; Aged; Aged, 80 and over; Biomarkers; Cardiac Catheterization; Cause of Death; Convalescence; Death, Sudden; Female; Follow-Up Studies; Heart Failure; Hemodynamics; Humans; Life Tables; Male; Middle Aged; Myocardial Infarction; Natriuretic Peptide, Brain; Neoplasms; Pneumonia; Proportional Hazards Models; Survival Analysis; Survival Rate